Identification

Name
Clotrimazole
Accession Number
DB00257  (APRD00244)
Type
Small Molecule
Groups
Approved, Vet Approved
Description

An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. [PubChem]

Structure
Thumb
Synonyms
  • 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole
  • 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole
  • 1-(O-Chloro-alpha,alpha-diphenylbenzyl)imidazole
  • 1-(o-Chloro-α,α-diphenylbenzyl)imidazole
  • 1-(o-Chlorotrityl)imidazole
  • 1-(α-(2-Chlorophenyl)benzhydryl)imidazole
  • Clotrimazole
  • Lotrimin (tn)
  • Mycelex (tn)
External IDs
BAY 5097 / BAY-5097
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ClotrimazoleCream10 mg/gTopicalTaro Pharmaceuticals U.S.A., Inc.1993-08-31Not applicableUs
ClotrimazoleLozenge10 mg/1Oral; TopicalWest Ward Pharmaceutical2004-07-29Not applicableUs
ClotrimazoleCream10 mg/gTopicalLake Erie Medical Dba Quality Care Produts Llc2010-08-04Not applicableUs
ClotrimazoleLozenge10 mg/1OralPhysicians Total Care, Inc.2009-07-23Not applicableUs
ClotrimazoleCream10 mg/gTopicalE. Fougera & CO., A division of Fougera Pharmaceuticals Inc.2008-09-02Not applicableUs
ClotrimazoleLozenge10 mg/1Oral; TopicalCardinal Health2004-07-29Not applicableUs
ClotrimazoleCream10 mg/gTopicalStat Rx USA1993-08-31Not applicableUs
ClotrimazoleSolution10 mg/mLTopicalTeva1996-07-102017-09-30Us
ClotrimazoleLozenge10 mg/1OralRemedy Repack2013-03-252017-01-18Us
ClotrimazoleLozenge10 mg/1Oral; TopicalWest Ward Pharmaceutical2004-07-29Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AlevazolOintment10 mg/gTopicalCapital Pharmaceutical2014-09-01Not applicableUs
Anti FungalLiquid1 g/100mLTopicalGuangzhou Ertiantang Pharmaceutical Co.,ltd2017-09-22Not applicableUs
Anti-FungalCream10 mg/gTopicalMPM Medical, Inc.2002-10-14Not applicableUs
AntifungalCream1 g/100gTopicalSafeway2008-11-20Not applicableUs
AntifungalCream1 g/100gTopicalGalentic Pharma (India) Private Limited2013-08-07Not applicableUs
AntifungalCream10 mg/gTopicalRite Aid2011-04-15Not applicableUs
Antifungal FootCream1 g/100gTopicalHyvee2015-11-28Not applicableUs
Aptrimazole 1.0% Antifungal CreamCream1 g/100gTopicalA P J Laboratories Limited2013-04-27Not applicableUs
Aspiera Anti-FungalOintment1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2012-05-31Not applicableUs
Athlete Foot Cream with ClotrimazoleCream1 g/100gTopicalSabel Med Llc2016-05-01Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ClotrimazoleCream1 g/100gVaginalCentral Texas Community Health Centers1995-12-04Not applicableUs
Shield and Protect Anti-FungalCream1.1 g/115gTopicalGentell, Inc.2007-01-01Not applicableUs
International/Other Brands
Canesten (Bayer) / Canifug (Dr. August Wolff) / Clotrimaderm (Taro) / Empecid (Bayer) / FemCare / Fungicip (Cipla) / Gyne-Lotrimin (Schering-Plough) / Mycelex (Bayer) / Myclo-Derm / Myclo-Gyne
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Betamethasone ClotrimazoleClotrimazole (10 mg/1) + Betamethasone dipropionate (.64 mg/1)CreamTopicalStat Rx USA2002-08-02Not applicableUs
Canesoral Combi-pakClotrimazole (1 %) + Fluconazole (150 mg)Capsule; CreamOral; Topical; VaginalBayer2010-03-10Not applicableCanada
Canesten 1 Vaginal Tablet Combi-pakClotrimazole (1 %) + Clotrimazole (500 mg)Cream; SuppositoryTopical; VaginalBayer Inc Consumer Care1995-12-312007-08-02Canada
Canesten 1 Vaginal Tablet Combi-pakClotrimazole (1 %) + Clotrimazole (500 mg)Cream; SuppositoryTopical; VaginalBayer Inc Consumer Care1995-12-312007-08-02Canada
Canesten 3 Vaginal Tablet Combi-pakClotrimazole (1 %) + Clotrimazole (200 mg)Cream; SuppositoryTopical; VaginalBayer Inc Consumer Care1995-12-312007-08-02Canada
Canesten 3 Vaginal Tablet Combi-pakClotrimazole (1 %) + Clotrimazole (200 mg)Cream; SuppositoryTopical; VaginalBayer Inc Consumer Care1995-12-312007-08-02Canada
Canesten Combi-pak 1 Day TherapyClotrimazole (1 %) + Clotrimazole (500 mg)Cream; SuppositoryTopical; VaginalMiles Inc. Pharmaceutical Division1994-12-311996-09-09Canada
Canesten Combi-pak 1 Day TherapyClotrimazole (1 %) + Clotrimazole (500 mg)Cream; SuppositoryTopical; VaginalMiles Inc. Pharmaceutical Division1994-12-311996-09-09Canada
Canesten Combi-pak Comfortab 1Clotrimazole (1 %) + Clotrimazole (500 mg)Cream; TabletTopical; VaginalBayer2006-05-12Not applicableCanada
Canesten Combi-pak Comfortab 1Clotrimazole (1 %) + Clotrimazole (500 mg)Cream; TabletTopical; VaginalBayer2006-05-12Not applicableCanada
Categories
UNII
G07GZ97H65
CAS number
23593-75-1
Weight
Average: 344.837
Monoisotopic: 344.108026261
Chemical Formula
C22H17ClN2
InChI Key
VNFPBHJOKIVQEB-UHFFFAOYSA-N
InChI
InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
IUPAC Name
1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole
SMILES
ClC1=CC=CC=C1C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1

Pharmacology

Indication

For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.

Structured Indications
Pharmacodynamics

Clotrimazole, an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. In studies in fungal cultures, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. Both of these events began rapidly and extensively after addition of the drug to the cultures. The primary action of clotrimazole is against dividing and growing organisms.

Mechanism of action

Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Clotrimazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.

TargetActionsOrganism
ALanosterol 14-alpha demethylase
antagonist
inhibitor
Yeast
AIntermediate conductance calcium-activated potassium channel protein 4
inhibitor
Human
UNuclear receptor subfamily 1 group I member 2
activator
Human
UNuclear receptor subfamily 1 group I member 3
partial agonist
Human
Absorption

Poorly and erratically absorbed orally, minimal vaginal or topical absorption.

Volume of distribution
Not Available
Protein binding

90%

Metabolism

Hepatic (metabolized to inactive metabolites)

Route of elimination
Not Available
Half life

2 hours

Clearance
Not Available
Toxicity

Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.

Affected organisms
  • Yeast and other fungi
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Clotrimazole.Experimental, Illicit
AbemaciclibThe metabolism of Abemaciclib can be decreased when combined with Clotrimazole.Approved
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Clotrimazole.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Clotrimazole.Approved, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Clotrimazole.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Clotrimazole.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Clotrimazole.Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Clotrimazole.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Clotrimazole.Approved
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Clotrimazole.Approved
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Clotrimazole.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Clotrimazole.Approved, Investigational
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Clotrimazole.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Clotrimazole.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Clotrimazole.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Clotrimazole.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Clotrimazole.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Clotrimazole.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Clotrimazole.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Clotrimazole.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Clotrimazole.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Clotrimazole.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Clotrimazole.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Clotrimazole.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Clotrimazole.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Clotrimazole.Approved
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Clotrimazole.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Clotrimazole.Approved
AmlodipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Amlodipine.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Clotrimazole.Approved, Investigational
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Clotrimazole.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Clotrimazole.Approved, Vet Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Clotrimazole.Approved, Illicit
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Clotrimazole.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Clotrimazole.Approved
AmrinoneThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Amrinone.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Clotrimazole.Approved
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Clotrimazole.Approved
AnilineThe metabolism of Aniline can be decreased when combined with Clotrimazole.Experimental
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Clotrimazole.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Clotrimazole.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Clotrimazole.Approved, Investigational
AprepitantThe metabolism of Aprepitant can be decreased when combined with Clotrimazole.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Clotrimazole.Approved
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Clotrimazole.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Clotrimazole.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Clotrimazole.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Clotrimazole.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Clotrimazole.Approved
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Clotrimazole resulting in a loss in efficacy.Approved, Investigational
AsenapineThe metabolism of Asenapine can be decreased when combined with Clotrimazole.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Clotrimazole.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Clotrimazole.Approved, Investigational
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Clotrimazole.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Atorvastatin.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Clotrimazole.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Clotrimazole.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Clotrimazole.Approved
AzelnidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Azelnidipine.Approved, Investigational
AzimilideThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Azimilide.Investigational
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Clotrimazole.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Clotrimazole.Investigational
BarnidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Barnidipine.Approved
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Clotrimazole.Approved
BencyclaneThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Bencyclane.Experimental
BendamustineThe metabolism of Bendamustine can be decreased when combined with Clotrimazole.Approved, Investigational
BenidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Benidipine.Approved, Investigational
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Clotrimazole.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Clotrimazole.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Clotrimazole.Approved
BepridilThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Bepridil.Approved, Withdrawn
BeraprostThe metabolism of Beraprost can be decreased when combined with Clotrimazole.Investigational
BetaxololThe metabolism of Betaxolol can be decreased when combined with Clotrimazole.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Clotrimazole.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Clotrimazole.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Clotrimazole.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Clotrimazole.Approved
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Clotrimazole.Approved, Withdrawn
BortezomibThe metabolism of Bortezomib can be decreased when combined with Clotrimazole.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Clotrimazole.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Clotrimazole.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Clotrimazole.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Clotrimazole.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Clotrimazole.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Clotrimazole.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be decreased when combined with Clotrimazole.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Clotrimazole.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Clotrimazole.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Clotrimazole.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Clotrimazole.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Clotrimazole.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Clotrimazole.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Clotrimazole.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Clotrimazole.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Clotrimazole.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Clotrimazole.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Clotrimazole.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Clotrimazole.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Clotrimazole.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Clotrimazole.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Clotrimazole.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Clotrimazole.Experimental
Candesartan cilexetilThe metabolism of Candesartan cilexetil can be decreased when combined with Clotrimazole.Approved
CapsaicinThe metabolism of Capsaicin can be decreased when combined with Clotrimazole.Approved
CaptoprilThe metabolism of Captopril can be decreased when combined with Clotrimazole.Approved
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Clotrimazole.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Clotrimazole.Approved
CarboxyamidotriazoleThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Carboxyamidotriazole.Investigational
CariprazineThe metabolism of Cariprazine can be decreased when combined with Clotrimazole.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Clotrimazole.Approved
CarmustineThe metabolism of Carmustine can be decreased when combined with Clotrimazole.Approved
CaroverineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Caroverine.Experimental
CarteololThe metabolism of Carteolol can be decreased when combined with Clotrimazole.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Clotrimazole.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Clotrimazole.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Clotrimazole.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Clotrimazole.Approved, Vet Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Clotrimazole.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Clotrimazole.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Clotrimazole.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Clotrimazole.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Clotrimazole.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Clotrimazole.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Clotrimazole.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Clotrimazole.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Clotrimazole.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Clotrimazole.Approved, Investigational
CilnidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Cilnidipine.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Clotrimazole.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Clotrimazole.Approved
CinnarizineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Cinnarizine.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Clotrimazole.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Clotrimazole.Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Clotrimazole.Approved
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
ClevidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Clevidipine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Clotrimazole.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Clotrimazole.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Clotrimazole.Approved, Investigational
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Clotrimazole.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Clotrimazole.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Clotrimazole.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Clotrimazole resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Clotrimazole.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Clotrimazole.Approved, Illicit
ClozapineThe metabolism of Clozapine can be decreased when combined with Clotrimazole.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Clotrimazole.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Clotrimazole.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Clotrimazole.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Clotrimazole.Approved
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Clotrimazole.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be decreased when combined with Clotrimazole.Approved
CopanlisibThe metabolism of Copanlisib can be decreased when combined with Clotrimazole.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Clotrimazole.Approved
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Clotrimazole.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Clotrimazole.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Clotrimazole.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Clotrimazole.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Clotrimazole.Approved
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Clotrimazole.Approved
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Clotrimazole.Approved, Investigational
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Clotrimazole.Approved
DalfampridineThe metabolism of Dalfampridine can be decreased when combined with Clotrimazole.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Clotrimazole.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Clotrimazole.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Clotrimazole.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Clotrimazole.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Clotrimazole.Approved, Investigational
DarodipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Darodipine.Experimental
DarunavirThe metabolism of Darunavir can be decreased when combined with Clotrimazole.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Clotrimazole.Approved
DasatinibThe metabolism of Dasatinib can be decreased when combined with Clotrimazole.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Clotrimazole.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Clotrimazole.Approved, Investigational
DeflazacortThe metabolism of Deflazacort can be decreased when combined with Clotrimazole.Approved
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Clotrimazole.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Clotrimazole.Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Clotrimazole.Approved
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Clotrimazole.Approved, Investigational
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Clotrimazole.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Clotrimazole.Approved, Illicit, Investigational, Withdrawn
DexlansoprazoleThe metabolism of Dexlansoprazole can be decreased when combined with Clotrimazole.Approved
DexmedetomidineThe metabolism of Dexmedetomidine can be decreased when combined with Clotrimazole.Approved, Vet Approved
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Clotrimazole.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Clotrimazole.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Clotrimazole.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Clotrimazole.Approved, Illicit, Investigational, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Clotrimazole.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Clotrimazole.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Clotrimazole.Approved
DidanosineDidanosine can cause a decrease in the absorption of Clotrimazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DienogestThe metabolism of Dienogest can be decreased when combined with Clotrimazole.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Clotrimazole.Approved, Investigational
DigoxinThe metabolism of Digoxin can be decreased when combined with Clotrimazole.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Clotrimazole.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Clotrimazole.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Clotrimazole.Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Clotrimazole.Experimental
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Clotrimazole.Approved
DiltiazemThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Diltiazem.Approved
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Clotrimazole.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Clotrimazole.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Clotrimazole.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Clotrimazole.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Clotrimazole.Approved, Investigational
DoconexentThe metabolism of Doconexent can be decreased when combined with Clotrimazole.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Clotrimazole.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Clotrimazole.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Clotrimazole.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Clotrimazole.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Clotrimazole.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Clotrimazole.Approved
DotarizineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Dotarizine.Investigational
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Clotrimazole.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Clotrimazole.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Clotrimazole.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Clotrimazole.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Clotrimazole.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Clotrimazole.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Clotrimazole.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Clotrimazole.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Clotrimazole.Approved
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Clotrimazole.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Efonidipine.Approved, Investigational
ElbasvirThe metabolism of Elbasvir can be decreased when combined with Clotrimazole.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Clotrimazole.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Clotrimazole.Approved
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Clotrimazole.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Clotrimazole.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Clotrimazole.Approved, Vet Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Clotrimazole.Approved
EncainideThe metabolism of Encainide can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Clotrimazole.Investigational
EnfluraneThe metabolism of Enflurane can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Clotrimazole.Approved, Investigational
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Clotrimazole.Approved
EperisoneThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Eperisone.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Clotrimazole.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Clotrimazole.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Clotrimazole.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Clotrimazole.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Clotrimazole.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Clotrimazole.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Clotrimazole.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Clotrimazole.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Clotrimazole.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Clotrimazole.Approved, Investigational
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Clotrimazole.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Clotrimazole.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Clotrimazole.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Clotrimazole.Approved, Investigational
EstramustineThe metabolism of Estramustine can be decreased when combined with Clotrimazole.Approved
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be decreased when combined with Clotrimazole.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Clotrimazole.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Clotrimazole.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Clotrimazole.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Clotrimazole.Approved
Ethanolamine OleateThe metabolism of Ethanolamine Oleate can be decreased when combined with Clotrimazole.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Clotrimazole.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Clotrimazole.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Clotrimazole.Approved, Illicit
EtizolamThe metabolism of Etizolam can be decreased when combined with Clotrimazole.Approved
EtodolacThe metabolism of Etodolac can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Clotrimazole.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Clotrimazole.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Clotrimazole.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Clotrimazole.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Clotrimazole.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Clotrimazole.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Clotrimazole.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Clotrimazole.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Clotrimazole.Approved
FelodipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Felodipine.Approved, Investigational
FendilineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Fendiline.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Clotrimazole.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Clotrimazole.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Clotrimazole.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Clotrimazole.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Clotrimazole.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Clotrimazole.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Clotrimazole.Approved
FlunarizineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Flunarizine.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Clotrimazole.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Clotrimazole.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Clotrimazole.Approved
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Clotrimazole.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Clotrimazole.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Clotrimazole.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Clotrimazole.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Clotrimazole.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Clotrimazole.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Clotrimazole.Approved
Fluticasone propionateThe metabolism of Fluticasone propionate can be decreased when combined with Clotrimazole.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Clotrimazole.Approved
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Clotrimazole.Approved, Investigational
Folic AcidThe metabolism of Folic Acid can be decreased when combined with Clotrimazole.Approved, Nutraceutical, Vet Approved
FormoterolThe metabolism of Formoterol can be decreased when combined with Clotrimazole.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Clotrimazole.Approved
FosphenytoinThe serum concentration of Clotrimazole can be decreased when it is combined with Fosphenytoin.Approved
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Clotrimazole.Approved, Investigational
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Clotrimazole.Approved, Investigational
GabapentinThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Gabapentin.Approved, Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Clotrimazole.Approved
GallopamilThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Gallopamil.Investigational
GavestinelThe metabolism of Gavestinel can be decreased when combined with Clotrimazole.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Clotrimazole.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Clotrimazole.Approved
GenisteinThe metabolism of Genistein can be decreased when combined with Clotrimazole.Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Clotrimazole.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Clotrimazole.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Clotrimazole.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Clotrimazole.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Clotrimazole.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Clotrimazole.Approved, Investigational
GrazoprevirThe metabolism of Grazoprevir can be decreased when combined with Clotrimazole.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Clotrimazole.Investigational, Withdrawn
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Clotrimazole.Approved, Investigational
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Clotrimazole.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Clotrimazole.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Clotrimazole.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Clotrimazole.Approved, Vet Approved
HesperetinThe metabolism of Hesperetin can be decreased when combined with Clotrimazole.Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Clotrimazole.Approved
HistamineThe metabolism of Histamine can be decreased when combined with Clotrimazole.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Clotrimazole.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Clotrimazole.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Clotrimazole.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Clotrimazole.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Clotrimazole.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Clotrimazole.Approved
IcotinibThe metabolism of Icotinib can be decreased when combined with Clotrimazole.Approved, Investigational
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Clotrimazole.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Clotrimazole resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Clotrimazole.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Clotrimazole.Approved
ImidafenacinThe metabolism of Imidafenacin can be decreased when combined with Clotrimazole.Approved, Investigational
ImipramineThe metabolism of Imipramine can be decreased when combined with Clotrimazole.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Clotrimazole.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Clotrimazole.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Clotrimazole.Approved
IndinavirThe metabolism of Indinavir can be decreased when combined with Clotrimazole.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Clotrimazole.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Clotrimazole.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Clotrimazole.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Clotrimazole.Approved, Investigational
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Clotrimazole.Approved, Investigational
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Clotrimazole.Approved, Investigational
IsofluraneThe metabolism of Isoflurane can be decreased when combined with Clotrimazole.Approved, Vet Approved
IsoniazidThe metabolism of Isoniazid can be decreased when combined with Clotrimazole.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Clotrimazole.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Clotrimazole.Approved
IsradipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Isradipine.Approved
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Clotrimazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Clotrimazole.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Clotrimazole.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Clotrimazole.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Clotrimazole.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Clotrimazole.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Clotrimazole.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Clotrimazole.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Clotrimazole.Approved, Investigational
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Clotrimazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Clotrimazole.Approved, Vet Approved
LabetalolThe metabolism of Labetalol can be decreased when combined with Clotrimazole.Approved
LacidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Lacidipine.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Lamotrigine.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Clotrimazole.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Clotrimazole.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Clotrimazole.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Clotrimazole.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Clotrimazole.Approved, Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Clotrimazole.Approved
LercanidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Lercanidipine.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Clotrimazole.Approved
LetermovirThe metabolism of Letermovir can be decreased when combined with Clotrimazole.Approved
LetrozoleThe metabolism of Letrozole can be decreased when combined with Clotrimazole.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Clotrimazole.Approved, Investigational
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Clotrimazole.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Clotrimazole.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Clotrimazole.Approved, Investigational
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Clotrimazole.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Clotrimazole.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Clotrimazole.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Clotrimazole.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Clotrimazole.Approved, Vet Approved
LidoflazineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Lidoflazine.Experimental
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Clotrimazole.Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Clotrimazole.Approved, Investigational
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Clotrimazole.Approved, Investigational
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Clotrimazole.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Clotrimazole.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Clotrimazole.Approved
LopinavirThe metabolism of Lopinavir can be decreased when combined with Clotrimazole.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Clotrimazole.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Clotrimazole.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Clotrimazole.Approved, Investigational
LosartanThe metabolism of Losartan can be decreased when combined with Clotrimazole.Approved
LovastatinThe metabolism of Lovastatin can be decreased when combined with Clotrimazole.Approved, Investigational
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Clotrimazole.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Clotrimazole.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Clotrimazole.Approved
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Clotrimazole.Illicit, Investigational, Withdrawn
MacitentanThe metabolism of Macitentan can be decreased when combined with Clotrimazole.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Magnesium Sulfate.Approved, Vet Approved
MalathionThe metabolism of Malathion can be decreased when combined with Clotrimazole.Approved, Investigational
ManidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Manidipine.Approved, Investigational
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Clotrimazole.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Clotrimazole.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Clotrimazole.Approved, Investigational
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Clotrimazole.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Clotrimazole.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Clotrimazole.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Clotrimazole.Approved, Vet Approved
MenadioneThe metabolism of Menadione can be decreased when combined with Clotrimazole.Approved, Nutraceutical
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Clotrimazole.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Clotrimazole.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Clotrimazole.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Clotrimazole.Approved, Investigational
MestranolThe metabolism of Mestranol can be decreased when combined with Clotrimazole.Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Clotrimazole.Experimental
MethadoneThe metabolism of Methadone can be decreased when combined with Clotrimazole.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Clotrimazole.Approved, Illicit
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Clotrimazole.Illicit, Withdrawn
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Clotrimazole.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Clotrimazole.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Clotrimazole.Approved
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Clotrimazole.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Clotrimazole.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Clotrimazole.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Clotrimazole.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Clotrimazole.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Clotrimazole.Approved, Illicit, Withdrawn
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Clotrimazole.Approved
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Clotrimazole.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Clotrimazole.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Clotrimazole.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Clotrimazole.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Clotrimazole.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Clotrimazole.Approved, Investigational
MibefradilThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Clotrimazole.Approved, Illicit
MidostaurinThe metabolism of Midostaurin can be decreased when combined with Clotrimazole.Approved
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Clotrimazole.Approved, Investigational
MinaprineThe metabolism of Minaprine can be decreased when combined with Clotrimazole.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Clotrimazole.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Clotrimazole.Approved
MitoxantroneThe metabolism of Mitoxantrone can be decreased when combined with Clotrimazole.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Clotrimazole.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Clotrimazole.Approved, Investigational
MontelukastThe metabolism of Montelukast can be decreased when combined with Clotrimazole.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Clotrimazole.Approved, Investigational
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Clotrimazole.Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Clotrimazole.Approved, Investigational
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Clotrimazole.Approved
NaftopidilThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Naftopidil.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Clotrimazole.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Clotrimazole.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Clotrimazole.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Clotrimazole.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Clotrimazole.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Clotrimazole.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Clotrimazole.Approved
NeratinibThe metabolism of Neratinib can be decreased when combined with Clotrimazole.Approved, Investigational
NetupitantThe metabolism of Netupitant can be decreased when combined with Clotrimazole.Approved
NevirapineThe metabolism of Nevirapine can be decreased when combined with Clotrimazole.Approved
NicardipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nicardipine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Clotrimazole.Approved, Investigational
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Clotrimazole.Approved
NifedipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nifedipine.Approved
NiguldipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Niguldipine.Experimental
NilotinibThe metabolism of Nilotinib can be decreased when combined with Clotrimazole.Approved, Investigational
NiludipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Niludipine.Experimental
NilutamideThe metabolism of Nilutamide can be decreased when combined with Clotrimazole.Approved
NilvadipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nilvadipine.Approved, Investigational
NimesulideThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nimesulide.Approved, Investigational, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Clotrimazole.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Clotrimazole.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nisoldipine.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Clotrimazole.Approved
NitrendipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nitrendipine.Approved, Investigational
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Clotrimazole.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Clotrimazole.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Clotrimazole.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Clotrimazole.Approved
OdanacatibThe metabolism of Odanacatib can be decreased when combined with Clotrimazole.Investigational
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Clotrimazole.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Clotrimazole.Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Clotrimazole.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Clotrimazole.Approved
OmbitasvirThe metabolism of Ombitasvir can be decreased when combined with Clotrimazole.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Clotrimazole.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Clotrimazole.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Clotrimazole.Approved
OtiloniumThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Otilonium.Experimental, Investigational
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Clotrimazole.Approved, Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Clotrimazole.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Clotrimazole.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Clotrimazole.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Clotrimazole.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Clotrimazole.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Clotrimazole.Approved, Vet Approved
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Clotrimazole.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Clotrimazole.Approved, Investigational
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Clotrimazole.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Clotrimazole.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Clotrimazole.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Clotrimazole.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Clotrimazole.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Clotrimazole.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Clotrimazole.Approved
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Clotrimazole.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Clotrimazole.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Clotrimazole.Approved
PentobarbitalThe metabolism of Pentobarbital can be decreased when combined with Clotrimazole.Approved, Vet Approved
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Clotrimazole.Approved, Investigational
PerampanelThe metabolism of Perampanel can be decreased when combined with Clotrimazole.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Perhexiline.Approved, Investigational
PermethrinThe metabolism of Permethrin can be decreased when combined with Clotrimazole.Approved, Investigational
PerospironeThe metabolism of Perospirone can be decreased when combined with Clotrimazole.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Clotrimazole.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Clotrimazole.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Clotrimazole.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
PhenobarbitalThe metabolism of Phenobarbital can be decreased when combined with Clotrimazole.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Clotrimazole.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Clotrimazole.Approved, Investigational
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Clotrimazole.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Clotrimazole.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Clotrimazole.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Clotrimazole.Approved, Investigational
PimozideClotrimazole may increase the arrhythmogenic activities of Pimozide.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Clotrimazole.Withdrawn
PinaveriumThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Pinaverium.Approved
PindololThe metabolism of Pindolol can be decreased when combined with Clotrimazole.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Clotrimazole.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Clotrimazole.Approved, Investigational
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Clotrimazole.Approved, Investigational
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Clotrimazole.Approved, Investigational
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Clotrimazole.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Clotrimazole.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Clotrimazole.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Clotrimazole.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Clotrimazole.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Clotrimazole.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Clotrimazole.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Clotrimazole.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Clotrimazole.Approved, Vet Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Clotrimazole.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Clotrimazole.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Pregabalin.Approved, Illicit, Investigational
PrenylamineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Prenylamine.Withdrawn
PrimaquineThe metabolism of Primaquine can be decreased when combined with Clotrimazole.Approved
PrimidoneThe metabolism of Primidone can be decreased when combined with Clotrimazole.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Clotrimazole.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ProgesteroneThe therapeutic efficacy of Progesterone can be decreased when used in combination with Clotrimazole.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Clotrimazole.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Clotrimazole.Approved
PropafenoneThe serum concentration of Clotrimazole can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
Propoxyphene napsylateThe metabolism of Propoxyphene napsylate can be decreased when combined with Clotrimazole.Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Clotrimazole.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Clotrimazole.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Clotrimazole.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Clotrimazole.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Clotrimazole.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Clotrimazole.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Clotrimazole.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Clotrimazole.Approved, Investigational
QuinidineThe metabolism of Quinidine can be decreased when combined with Clotrimazole.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Clotrimazole.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Clotrimazole.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Clotrimazole.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Clotrimazole.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Clotrimazole.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Clotrimazole.Approved, Investigational
RasagilineThe metabolism of Rasagiline can be decreased when combined with Clotrimazole.Approved
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Clotrimazole.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Clotrimazole.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Clotrimazole.Approved, Withdrawn
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Clotrimazole.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Clotrimazole.Investigational
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Clotrimazole.Approved, Experimental, Investigational
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Clotrimazole.Approved
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Clotrimazole.Approved
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Clotrimazole.Approved
RifapentineThe serum concentration of Rifapentine can be increased when it is combined with Clotrimazole.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Clotrimazole.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Clotrimazole.Approved
RiluzoleThe metabolism of Riluzole can be decreased when combined with Clotrimazole.Approved, Investigational
RimonabantThe metabolism of Rimonabant can be decreased when combined with Clotrimazole.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Clotrimazole.Approved
RisedronateThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Risedronate.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be decreased when combined with Clotrimazole.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Clotrimazole.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Clotrimazole.Approved
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Clotrimazole.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Clotrimazole.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Clotrimazole.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Clotrimazole.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Clotrimazole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Clotrimazole.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Clotrimazole.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Clotrimazole.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Clotrimazole.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
RucaparibThe metabolism of Rucaparib can be decreased when combined with Clotrimazole.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Clotrimazole.Approved
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Clotrimazole.Approved
SafinamideThe metabolism of Safinamide can be decreased when combined with Clotrimazole.Approved
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Clotrimazole.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Clotrimazole.Approved
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Clotrimazole.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Clotrimazole.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Clotrimazole.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Clotrimazole.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Clotrimazole.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Clotrimazole.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Clotrimazole.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be decreased when combined with Clotrimazole.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Clotrimazole.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Clotrimazole.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Clotrimazole.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Clotrimazole.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Clotrimazole.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Clotrimazole.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Clotrimazole.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Clotrimazole.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Clotrimazole.Approved, Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Clotrimazole.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Clotrimazole.Approved
StiripentolThe metabolism of Stiripentol can be decreased when combined with Clotrimazole.Approved
SucralfateSucralfate can cause a decrease in the absorption of Clotrimazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Clotrimazole.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Clotrimazole.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Clotrimazole.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Clotrimazole.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Clotrimazole.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Clotrimazole.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Clotrimazole.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Clotrimazole.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Clotrimazole.Approved
TacrineThe metabolism of Tacrine can be decreased when combined with Clotrimazole.Investigational, Withdrawn
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Clotrimazole.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Clotrimazole.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Clotrimazole resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Clotrimazole.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Clotrimazole.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Clotrimazole.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Clotrimazole.Experimental
TazaroteneThe metabolism of Tazarotene can be decreased when combined with Clotrimazole.Approved, Investigational
TegafurThe serum concentration of the active metabolites of Tegafur can be reduced when Tegafur is used in combination with Clotrimazole resulting in a loss in efficacy.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Clotrimazole.Investigational, Withdrawn
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Clotrimazole.Approved, Withdrawn
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Clotrimazole.Approved
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Clotrimazole.Withdrawn
TemazepamThe metabolism of Temazepam can be decreased when combined with Clotrimazole.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Clotrimazole.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Clotrimazole.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Clotrimazole.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Clotrimazole.Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Clotrimazole.Experimental
TerodilineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Terodiline.Experimental
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Clotrimazole.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Clotrimazole.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Clotrimazole.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Clotrimazole.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Tetrahydropalmatine.Investigational
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
TheobromineThe metabolism of Theobromine can be decreased when combined with Clotrimazole.Approved, Investigational
TheophyllineThe metabolism of Theophylline can be decreased when combined with Clotrimazole.Approved
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Clotrimazole.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Clotrimazole.Approved, Withdrawn
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Clotrimazole.Approved
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Clotrimazole.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Clotrimazole.Approved
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Clotrimazole.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Clotrimazole.Approved
TimololThe metabolism of Timolol can be decreased when combined with Clotrimazole.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Clotrimazole.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Clotrimazole.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Clotrimazole.Approved, Investigational
TirapazamineThe metabolism of Tirapazamine can be decreased when combined with Clotrimazole.Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Clotrimazole.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Clotrimazole.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Clotrimazole.Approved
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Tolfenamic Acid.Approved
TolperisoneThe metabolism of AV650 can be decreased when combined with Clotrimazole.Approved, Investigational
TolterodineThe metabolism of Tolterodine can be decreased when combined with Clotrimazole.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Clotrimazole.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Clotrimazole.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Clotrimazole.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Clotrimazole.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Clotrimazole.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Clotrimazole.Approved, Investigational
TranilastThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Tranilast.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Clotrimazole.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Clotrimazole.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Clotrimazole.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Clotrimazole.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Clotrimazole.Approved, Vet Approved
TriamtereneThe metabolism of Triamterene can be decreased when combined with Clotrimazole.Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Clotrimazole.Approved
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Clotrimazole.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Clotrimazole.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Clotrimazole.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Clotrimazole.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Clotrimazole.Investigational, Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Clotrimazole.Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Clotrimazole.Approved, Investigational, Nutraceutical
UdenafilThe metabolism of Udenafil can be decreased when combined with Clotrimazole.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Clotrimazole.Approved
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Clotrimazole.Approved
VadimezanThe metabolism of Vadimezan can be decreased when combined with Clotrimazole.Investigational
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Clotrimazole.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Clotrimazole.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Clotrimazole.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Clotrimazole.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Clotrimazole.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Clotrimazole.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Clotrimazole.Approved
VelpatasvirThe metabolism of Velpatasvir can be decreased when combined with Clotrimazole.Approved
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Clotrimazole.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Clotrimazole.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Clotrimazole.Approved
VerapamilThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Verapamil.Approved
VernakalantThe metabolism of Vernakalant can be decreased when combined with Clotrimazole.Approved, Investigational
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Clotrimazole.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Clotrimazole.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Clotrimazole.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Clotrimazole.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Clotrimazole.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Clotrimazole.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Clotrimazole.Approved, Investigational
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Clotrimazole.Approved, Investigational
VinpocetineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Vinpocetine.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Clotrimazole.Approved
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Clotrimazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Clotrimazole.Approved
VoxilaprevirThe metabolism of Voxilaprevir can be decreased when combined with Clotrimazole.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Clotrimazole.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
XylometazolineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Xylometazoline.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Clotrimazole.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Clotrimazole.Approved, Investigational
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Clotrimazole.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Clotrimazole.Approved, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Ziconotide.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Clotrimazole.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Clotrimazole.Approved
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Clotrimazole.Approved, Investigational
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Clotrimazole.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Clotrimazole.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Clotrimazole.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Clotrimazole.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Clotrimazole.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Buechel, K.H., et al; South African Patent 69/0039; January 3, 1969; assigned to Farben- Buechel, K.H., Regel, E. and Plempel, M.; US. Patent 3,660,577; May 2,1972; and U.S. fabriken Bayer AG, Germany. Patent 3,705,172; Dec. 5,1972; both assigned to Farbenfabriken Bayer A.G. (Germany).

US3705172
General References
Not Available
External Links
Human Metabolome Database
HMDB01922
KEGG Drug
D00282
KEGG Compound
C06922
PubChem Compound
2812
PubChem Substance
46507927
ChemSpider
2710
BindingDB
31774
ChEBI
3764
ChEMBL
CHEMBL104
Therapeutic Targets Database
DAP000138
PharmGKB
PA449057
IUPHAR
2330
Guide to Pharmacology
GtP Drug Page
HET
CL6
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Clotrimazole
ATC Codes
G01AF02 — ClotrimazoleD01AC01 — ClotrimazoleA01AB18 — Clotrimazole
AHFS Codes
  • 84:04.08.08 — Azoles
PDB Entries
2xfh / 3mdv / 4xe3
FDA label
Download (139 KB)
MSDS
Download (73.8 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedPreventionHIV- Prevention1
1CompletedTreatmentAutoimmune Diseases / Disseminated or Multiple Sclerosis Nos / Disseminated Sclerosis / Multiple Sclerosis, Acute Relapsing / Multiple Sclerosis, Chronic Progressive / Multiple Sclerosis, Primary Progressive1
1, 2CompletedTreatmentKidney Diseases / Transplantation, Kidney1
1, 2CompletedTreatmentSickle Cell Disorders1
1, 2Not Yet RecruitingTreatmentVulvovaginal Candidiasis1
1, 2SuspendedTreatmentIleitis / Inflammatory Bowel Diseases (IBD) / Pouchitis / Ulcerative Colitis (UC)1
2, 3Not Yet RecruitingTreatmentInfections, Fungal1
2, 3Not Yet RecruitingTreatmentCandidiasis infection1
2, 3RecruitingTreatmentVulvovaginal Candidiasis (VVC)1
2, 3SuspendedTreatmentFolliculitis1
3CompletedPreventionCandidiasis infection / Human Immunodeficiency Virus (HIV) Infections / Mycoses1
3CompletedTreatmentClotrimazole / Ovulen / Vulvovaginal Candidiasis1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
3CompletedTreatmentOtomycosis1
3Unknown StatusTreatmentInfections, Fungal / Tinea Corporis / Tinea Cruris / Tinea Pedis1
3WithdrawnTreatmentSexual Active Women / Vaginal Discharge1
4RecruitingTreatmentBacterial Vaginosis (BV) / Candidiasis infection1
4TerminatedTreatmentAtopic Dermatitis (AD) / Skin Diseases, Eczematous1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Oral Candidiasis1
Not AvailableCompletedTreatmentOtomycosis1
Not AvailableCompletedTreatmentSickle Cell Disorders1
Not AvailableNo Longer AvailableNot AvailableDiabetes, Diabetes Mellitus Type 11

Pharmacoeconomics

Manufacturers
  • Schering plough healthcare products inc
  • Bayer pharmaceuticals corp
  • Glenmark pharmaceuticals inc usa
  • Nycomed us inc
  • Taro pharmaceuticals usa inc
  • Actavis mid atlantic llc
  • Taro pharmaceuticals inc
  • Schering corp sub schering plough corp
  • Teva pharmaceuticals usa inc
  • Bayer healthcare pharmaceuticals inc
  • Teva pharmaceuticals usa
  • Paddock laboratories inc
  • Roxane laboratories inc
Packagers
Dosage forms
FormRouteStrength
OintmentTopical10 mg/g
LiquidTopical1 g/100mL
CreamTopical350 mg/35g
LotionTopical1 g/100mL
CreamTopical.01 g/g
Capsule; creamOral; Topical; Vaginal
SolutionTopical1 %
CreamTopical; Vaginal2 %
SuppositoryVaginal200 mg
Cream; suppositoryTopical; Vaginal
Cream; tabletTopical; Vaginal
CreamTopical; Vaginal
TabletVaginal500 mg
TabletVaginal200 mg
CreamVaginal10 %
CreamTopical1 %
CreamTopical; Vaginal1 %
LiquidTopical1 %
SuppositoryVaginal100 mg
CreamTopical1 g/g
Capsule; cream; kitOral; Topical
CreamTopical50 mg/g
CreamVaginal1 g/100g
CreamVaginal10 mg/g
LiquidTopical1 mg/mL
LozengeOral10 mg/1
LozengeOral; Topical10 mg/1
SolutionTopical1 g/mL
CreamTopical
LotionTopical
CreamTopical10 mg/g
CreamVaginal1 %
CreamVaginal2 %
SolutionTopical10 mg/mL
SolutionTopical1 mg/mL
Kit
Aerosol, sprayTopical1 mL/100mL
Aerosol, foamTopical1 g/100g
LiquidTopical10 g/1000g
SolutionTopical1 g/100mL
GelTopical10 mg/g
SprayTopical4 mg/mL
PowderTopical1 g/100g
CreamTopical6 mg/mL
CreamTopical10 g/g
OintmentTopical1 mg/100g
GelTopical1 g/100g
CreamTopical420 mg/42g
LiquidTopical10 mg/mL
CreamVaginal50 mg
LiquidTopical10 mg
CreamTopical10 mg
SolutionTopical10 mg
CreamTopical; Vaginal10 mg
Aerosol, foamTopical10 mg/g
OilTopical10 mg/mL
CreamTopical10 mg/mL
CreamTopical.01 mg/10g
CreamTopical1 g/100g
CreamTopical1.1 g/115g
OintmentTopical1 g/100g
Kit
CreamVaginal2 g/100g
CreamTopical10 mg/100g
Prices
Unit descriptionCostUnit
Clotrimazole 70 10 mg Troche Bottle117.04USD bottle
Clotrimazole 1% Cream 45 gm Tube49.99USD tube
Clotrimazole 1% Cream 30 gm Tube35.99USD tube
Clotrimazole 1% Solution 30ml Bottle24.99USD bottle
Clotrimazole 1% Cream 15 gm Tube17.99USD tube
Clotrimazole 1% Solution 10ml Bottle17.99USD bottle
Clotrimazole powder5.2USD g
Mycelex 10 mg troche1.85USD troche
Clotrimazole 10 mg troche1.61USD troche
Mycelex-7 100 mg vaginal tablet1.33USD tablet
Lotrimin 1% cream1.28USD g
Gyne-lotrimin insert1.03USD insert
Mycelex 1% cream0.9USD g
Clotrimazole insert0.86USD insert
Lotrimin ultra 1% cream0.68USD g
Clotrimazole 1% cream0.53USD g
Clotrimazole 3 2% cream0.5USD g
Ra clotrimazole 3 cream0.46USD g
Ra athlete's 1% foot cream0.37USD g
Desenex 1% cream0.33USD g
CVS Pharmacy clotrimazole 1% cream0.32USD g
Antifungal 1% cream0.27USD g
Sm antifungal 1% cream0.25USD g
Ra clotrimazole af cream0.24USD g
Clotrim 1% vaginal cream0.18USD g
Lotrimin af 2% spray powder0.05USD g
Lotrimin af 2% liquid spray0.04USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)154-156Buechel, K.H., et al; South African Patent 69/0039; January 3, 1969; assigned to Farben- Buechel, K.H., Regel, E. and Plempel, M.; US. Patent 3,660,577; May 2,1972; and U.S. fabriken Bayer AG, Germany. Patent 3,705,172; Dec. 5,1972; both assigned to Farbenfabriken Bayer A.G. (Germany).
water solubility29.84 mg/mLNot Available
logP6.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00147 mg/mLALOGPS
logP5.48ALOGPS
logP5.84ChemAxon
logS-5.4ALOGPS
pKa (Strongest Basic)6.62ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area17.82 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity103.76 m3·mol-1ChemAxon
Polarizability36.25 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9725
Blood Brain Barrier+0.9837
Caco-2 permeable+0.6858
P-glycoprotein substrateNon-substrate0.7185
P-glycoprotein inhibitor INon-inhibitor0.6612
P-glycoprotein inhibitor IINon-inhibitor0.7884
Renal organic cation transporterNon-inhibitor0.5854
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9149
CYP450 3A4 substrateNon-substrate0.6262
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorInhibitor0.8948
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorInhibitor0.8478
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9799
Ames testNon AMES toxic0.7428
CarcinogenicityNon-carcinogens0.9018
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.7194 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9659
hERG inhibition (predictor II)Inhibitor0.6779
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-004i-1490000000-442fa75d6a2d80321e36
MS/MS Spectrum - Quattro_QQQ 10V, N/ALC-MS/MSsplash10-004i-0090000000-9ac001e37a55e61bc916
MS/MS Spectrum - Quattro_QQQ 25V, N/ALC-MS/MSsplash10-004i-0290000000-6285150b307e50af52c7
MS/MS Spectrum - Quattro_QQQ 40V, N/ALC-MS/MSsplash10-016u-0690000000-5814802384fae84ca3df
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-004i-0090000000-23b69c41217f6b148307
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-016r-0960000000-5b3632c056ca1c0fa601
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-016r-0950000000-bcb189995c8cdcd62304
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-004i-0090000000-f1d5f44ac74388f9bf4f
MS/MS Spectrum - , positiveLC-MS/MSsplash10-004i-1490000000-1ed188e9911ad62a7fc7
MS/MS Spectrum - , positiveLC-MS/MSsplash10-004i-0390000000-c2f0490842646cf25d56
MS/MS Spectrum - , positiveLC-MS/MSsplash10-014l-3970000000-0cf80068015e539b67c9
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-00or-0391000000-e8d9d4c77703a87fdcd8
1H NMR Spectrum1D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as triphenyl compounds. These are aromatic compounds containing a triphenyl moiety.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Triphenyl compounds
Sub Class
Not Available
Direct Parent
Triphenyl compounds
Alternative Parents
Chlorobenzenes / N-substituted imidazoles / Aryl chlorides / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organochlorides / Hydrocarbon derivatives
Substituents
Triphenyl compound / Chlorobenzene / Halobenzene / Aryl chloride / Aryl halide / Monocyclic benzene moiety / N-substituted imidazole / Azole / Heteroaromatic compound / Imidazole
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
conazole antifungal drug, imidazoles, imidazole antifungal drug, monochlorobenzenes (CHEBI:3764) / a small molecule (CPD-8926)

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
Yes
Actions
Antagonist
Inhibitor
General Function
Sterol 14-demethylase activity
Specific Function
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name
ERG11
Uniprot ID
P10613
Uniprot Name
Lanosterol 14-alpha demethylase
Molecular Weight
60674.965 Da
References
  1. Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL: Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45. doi: 10.1128/AAC.00587-10. Epub 2010 Jul 12. [PubMed:20625155]
  2. Gachotte D, Pierson CA, Lees ND, Barbuch R, Koegel C, Bard M: A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11173-8. [PubMed:9326581]
  3. Henry KW, Nickels JT, Edlind TD: Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother. 2000 Oct;44(10):2693-700. [PubMed:10991846]
  4. Lorenz RT, Parks LW: Physiological effects of fenpropimorph on wild-type Saccharomyces cerevisiae and fenpropimorph-resistant mutants. Antimicrob Agents Chemother. 1991 Aug;35(8):1532-7. [PubMed:1929324]
  5. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Protein phosphatase binding
Specific Function
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Requi...
Gene Name
KCNN4
Uniprot ID
O15554
Uniprot Name
Intermediate conductance calcium-activated potassium channel protein 4
Molecular Weight
47695.12 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  2. Brugnara C, Gee B, Armsby CC, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS: Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1996 Mar 1;97(5):1227-34. [PubMed:8636434]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Activator
General Function
Zinc ion binding
Specific Function
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism an...
Gene Name
NR1I2
Uniprot ID
O75469
Uniprot Name
Nuclear receptor subfamily 1 group I member 2
Molecular Weight
49761.245 Da
References
  1. Faucette SR, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, Yan B, Negishi M, LeCluyse EL: Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos. 2004 Mar;32(3):348-58. [PubMed:14977870]
  2. Smith CM, Faucette SR, Wang H, LeCluyse EL: Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers. J Biochem Mol Toxicol. 2005;19(2):96-108. [PubMed:15849716]
  3. Svecova L, Vrzal R, Burysek L, Anzenbacherova E, Cerveny L, Grim J, Trejtnar F, Kunes J, Pour M, Staud F, Anzenbacher P, Dvorak Z, Pavek P: Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos. 2008 Feb;36(2):339-48. Epub 2007 Nov 12. [PubMed:17998298]
  4. Dring AM, Anderson LE, Qamar S, Stoner MA: Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands. Chem Biol Interact. 2010 Dec 5;188(3):512-25. doi: 10.1016/j.cbi.2010.09.018. Epub 2010 Oct 20. [PubMed:20869355]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Partial agonist
General Function
Zinc ion binding
Specific Function
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital re...
Gene Name
NR1I3
Uniprot ID
Q14994
Uniprot Name
Nuclear receptor subfamily 1 group I member 3
Molecular Weight
39942.145 Da
References
  1. Kanno Y, Inouye Y: A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells. J Toxicol Sci. 2010 Aug;35(4):515-25. [PubMed:20686338]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Details
2. Cytochrome P450 3A4
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Kao J, King SP, Miwa G, Ni L, Kumar G, McLeod J, Obach SR, Roberts S, Roe A, Shah A, Snikeris F, Sullivan JT, Tweedie D, Vega JM, Walsh J, Wrighton SA: The conduct of in vitro and in vivo drug-drug interaction studies: a PhRMA perspective. J Clin Pharmacol. 2003 May;43(5):443-69. [PubMed:12751267]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. [PubMed:17101742]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name
CYP11A1
Uniprot ID
P05108
Uniprot Name
Cholesterol side-chain cleavage enzyme, mitochondrial
Molecular Weight
60101.87 Da
References
  1. Mason JI, Murry BA, Olcott M, Sheets JJ: Imidazole antimycotics: inhibitors of steroid aromatase. Biochem Pharmacol. 1985 Apr 1;34(7):1087-92. [PubMed:3921030]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid 11-beta-monooxygenase activity
Specific Function
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochro...
Gene Name
CYP11B1
Uniprot ID
P15538
Uniprot Name
Cytochrome P450 11B1, mitochondrial
Molecular Weight
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Details
8. Cytochrome P450 19A1
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxygen binding
Specific Function
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Gene Name
CYP19A1
Uniprot ID
P11511
Uniprot Name
Aromatase
Molecular Weight
57882.48 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Const...
Gene Name
CYP2A6
Uniprot ID
P11509
Uniprot Name
Cytochrome P450 2A6
Molecular Weight
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
Gene Name
CYP2E1
Uniprot ID
P05181
Uniprot Name
Cytochrome P450 2E1
Molecular Weight
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Organic anion transmembrane transporter activity
Specific Function
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocyte...
Gene Name
ABCC3
Uniprot ID
O15438
Uniprot Name
Canalicular multispecific organic anion transporter 2
Molecular Weight
169341.14 Da
References
  1. Teng S, Jekerle V, Piquette-Miller M: Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. [PubMed:14570758]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
Inducer
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. [PubMed:11297522]
  2. Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. [PubMed:8632764]
  3. Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. [PubMed:11961113]
  4. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389]
  5. Bain LJ, LeBlanc GA: Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein. Toxicol Appl Pharmacol. 1996 Nov;141(1):288-98. [PubMed:8917702]
  6. Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. [PubMed:12235267]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Organic anion transmembrane transporter activity
Specific Function
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name
ABCC2
Uniprot ID
Q92887
Uniprot Name
Canalicular multispecific organic anion transporter 1
Molecular Weight
174205.64 Da
References
  1. Kauffmann HM, Pfannschmidt S, Zoller H, Benz A, Vorderstemann B, Webster JI, Schrenk D: Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46. [PubMed:11836020]

Drug created on June 13, 2005 07:24 / Updated on December 10, 2017 17:18