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Identification
NameClotrimazole
Accession NumberDB00257  (APRD00244)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionAn imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. [PubChem]
Structure
Thumb
Synonyms
1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole
1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole
1-(O-Chloro-alpha,alpha-diphenylbenzyl)imidazole
1-(o-Chloro-α,α-diphenylbenzyl)imidazole
1-(o-Chlorotrityl)imidazole
1-(α-(2-Chlorophenyl)benzhydryl)imidazole
Clotrimazole
Lotrimin (tn)
Mycelex (tn)
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ClotrimazoleLozenge10 mg/1OralPhysicians Total Care, Inc.2009-07-23Not applicableUs
ClotrimazoleCream10 mg/gTopicalE. Fougera & CO., A division of Fougera Pharmaceuticals Inc.2008-09-02Not applicableUs
ClotrimazoleLozenge10 mg/1Oral; TopicalWest Ward Pharmaceuticals Corp.2004-07-29Not applicableUs
ClotrimazoleSolution10 mg/mLTopicalTaro Pharmaceuticals U.S.A., Inc.1996-07-29Not applicableUs
ClotrimazoleLozenge10 mg/1Oral; TopicalCardinal Health2004-07-29Not applicableUs
ClotrimazoleLozenge10 mg/1OralPaddock Laboratories, LLC2005-12-01Not applicableUs
ClotrimazoleSolution10 mg/mLTopicalTeva Pharmaceuticals USA Inc1996-07-10Not applicableUs
ClotrimazoleCream10 mg/gTopicalTaro Pharmaceuticals U.S.A., Inc.1993-08-31Not applicableUs
ClotrimazoleCream10 mg/gTopicalGlenmark Pharmaceuticals Inc., Usa2010-08-04Not applicableUs
ClotrimazoleCream10 mg/gTopicalSTAT Rx USA LLC1993-08-31Not applicableUs
ClotrimazoleLozenge10 mg/1OralREMEDYREPACK INC.2013-03-25Not applicableUs
ClotrimazoleLozenge10 mg/1Oral; TopicalWest Ward Pharmaceuticals Corp.2004-07-29Not applicableUs
ClotrimazoleCream10 mg/gTopicalLake Erie Medical DBA Quality Care Products LLC2010-08-04Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AlevazolOintment10 mg/gTopicalCapital Pharmaceutical, Llc2014-09-01Not applicableUs
Anti-fungalCream10 mg/gTopicalMPM Medical, Inc.2002-10-14Not applicableUs
AntifungalCream1 g/100gTopicalGalentic Pharma (India) Priva Te Limited2013-08-07Not applicableUs
AntifungalCream1 g/100gTopicalSafeway2008-11-20Not applicableUs
Antifungal CreamCream10 mg/gTopicalRite Aid2011-04-15Not applicableUs
Antifungal FootCream1 g/100gTopicalHy Vee Inc2015-11-28Not applicableUs
Aptrimazole 1.0% Antifungal CreamCream1 g/100gTopicalA P J Laboratories Limited2013-04-27Not applicableUs
Aspiera Anti-fungalOintment1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2012-05-31Not applicableUs
Athlete Foot Cream With ClotrimazoleCream1 g/100gTopicalSabel Med Llc2016-05-01Not applicableUs
Athlete S Foot AfacCream.01 g/gTopicalNatureplex, LLC2008-01-22Not applicableUs
Athletes Foot Antifungal AntifungalCream350 mg/35gTopicalPersonal Care Products, Inc.2013-07-10Not applicableUs
Atopalm Clotrimazole AntifungalCream1 g/100gTopicalNeo Pharm Co., Ltd.2011-03-16Not applicableUs
Best Choice ClotrimazoleCream10 mg/gTopicalValu Merchandisers Company1993-08-31Not applicableUs
Blossom Pharmaceuticals AntifungalCream1 g/100gTopicalBlossom Pharmaceticals2014-05-09Not applicableUs
Budpak Antifungal ClotrimazoleCream.01 g/gTopicalBudpak Inc.2012-12-17Not applicableUs
Canesten 1% Topical CreamCream1 %TopicalBayer Inc Consumer Care1995-12-31Not applicableCanada
Canesten 1% Topical SolutionSolution1 %TopicalBayer Inc Consumer Care1995-12-312000-08-04Canada
Canesten 100mg Vaginal InsertsSuppository100 mgVaginalBayer Inc Consumer Care1995-12-311997-08-01Canada
Canesten 2% Vaginal CreamCream2 %Topical; VaginalMiles Canada Inc. Consumer Health Care Division1994-12-311996-09-09Canada
Canesten 200 Mg Vaginal InsertsSuppository200 mgVaginalMiles Canada Inc. Consumer Health Care Division1994-12-311996-09-09Canada
Canesten Comfortab 1Tablet500 mgVaginalBayer Inc Consumer Care1995-12-31Not applicableCanada
Canesten Comfortab 3Tablet200 mgVaginalBayer Inc Consumer Care1995-12-31Not applicableCanada
Canesten Cream 1Cream10 %VaginalBayer Inc Consumer Care1997-06-11Not applicableCanada
Canesten Cream 3Cream2 %VaginalBayer Inc Consumer Care1995-12-31Not applicableCanada
Canesten Cream 6Cream1 %VaginalBayer Inc Consumer Care1995-12-31Not applicableCanada
Canesten Crm 1% TopCream1 %TopicalMiles Canada Inc. Consumer Health Care Division1994-12-311996-09-09Canada
Canesten Crm 1% VagCream1 %VaginalMiles Canada Inc. Consumer Health Care Division1994-12-311996-09-09Canada
Canesten External CreamCream1 %Topical; VaginalBayer Inc Consumer Care2010-03-10Not applicableCanada
Canesten External Cream RefillCream1 %TopicalBayer Inc Consumer Care2000-06-02Not applicableCanada
Canesten Liq 1%Liquid1 %TopicalMiles Canada Inc. Consumer Health Care Division1994-12-311996-09-09Canada
Canesten VCream2 g/100gVaginalGenesis Imports & Exports Llc2016-05-17Not applicableUs
Canesten Vaginal Inserts 100mgSuppository100 mgVaginalMiles Canada Inc. Consumer Health Care Division1994-12-311996-09-09Canada
Careall ClotrimazoleCream1 g/gTopicalNew World Imports, Inc2016-03-21Not applicableUs
Careone ClotrimazoleCream10 mg/gTopicalAmerican Sales Company1993-08-31Not applicableUs
Clotrimaderm Cream 1%Cream1 %TopicalTaro Pharmaceuticals Inc1988-12-31Not applicableCanada
Clotrimaderm External CreamCream1 %TopicalTaro Pharmaceuticals IncNot applicableNot applicableCanada
Clotrimaderm Topical Solution 1% USPLiquid10 mgTopicalTaro Pharmaceuticals IncNot applicableNot applicableCanada
Clotrimaderm Vag Cream 1%Cream1 %VaginalTaro Pharmaceuticals Inc1989-12-31Not applicableCanada
Clotrimaderm Vag Cream 2%Cream2 %VaginalTaro Pharmaceuticals Inc1989-12-31Not applicableCanada
Clotrimazoil AntifungalSolution10 mg/mLTopicalPEDIFIX, INC.2013-06-19Not applicableUs
ClotrimazoleSolution1 g/mLTopicalTaro Pharmaceuticals U.S.A., Inc.1996-05-01Not applicableUs
ClotrimazoleCream1 g/100gTopicalProficient Rx LP2011-06-03Not applicableUs
ClotrimazoleLiquid10 mg/mLTopicalPedifix2014-05-05Not applicableUs
ClotrimazoleCream1 g/100gTopicalRebel Distributors Corp2011-06-03Not applicableUs
ClotrimazoleCream1 g/100gTopicalDiscount Drug Mart, Inc.2015-11-09Not applicableUs
ClotrimazoleCream1 g/100gTopicalKareway Product, Inc.2011-08-11Not applicableUs
ClotrimazoleCream1 g/100gTopicalPerrigo New York Inc2011-06-03Not applicableUs
ClotrimazoleCream1 g/100gVaginalCentral Texas Community Health Centers2003-08-12Not applicableUs
ClotrimazoleCream50 mg/gTopicalRebel Distributors Corp.1993-07-16Not applicableUs
ClotrimazoleCream1 g/100gTopicalPromex, LLC2013-12-04Not applicableUs
ClotrimazoleCream10 mg/gTopicalPreferred Pharmaceuticals, Inc.2013-08-06Not applicableUs
ClotrimazoleLiquid1 mg/mLTopicalWalgreens2015-11-01Not applicableUs
ClotrimazoleCream10 mg/gTopicalPhysicians Total Care, Inc.2003-08-07Not applicableUs
ClotrimazoleCream1 g/100gVaginalChain Drug Marketing Association Inc.2014-10-15Not applicableUs
ClotrimazoleCream1 g/100gVaginalWalgreen Company1998-09-01Not applicableUs
ClotrimazoleCream1 g/100gTopicalGeritrex Corp2014-07-29Not applicableUs
ClotrimazoleCream1 g/100gVaginalCentral Texas Community Health Centers2003-08-12Not applicableUs
ClotrimazoleCream1 g/100gVaginalPreferred Pharmaceuticals, Inc.2013-08-06Not applicableUs
ClotrimazoleCream1 g/100gVaginalREMEDYREPACK INC.2015-04-02Not applicableUs
ClotrimazoleCream1 g/100gVaginalPreferred Pharmaceuticals, Inc.2013-08-05Not applicableUs
ClotrimazoleCream10 mg/gTopicalCardinal Health1993-08-31Not applicableUs
ClotrimazoleCream1 g/100gTopicalTaro Pharmaceuticals U.S.A., Inc.1995-06-01Not applicableUs
ClotrimazoleSolution1 g/mLTopicalTaro Pharmaceuticals, Inc.1996-05-01Not applicableUs
ClotrimazoleCream1 g/100gTopicalPreferred Pharmaceuticals Inc.2016-10-10Not applicableUs
ClotrimazoleCream2 g/100gVaginalTaro Pharmaceuticals U.S.A., Inc.2000-04-12Not applicableUs
ClotrimazoleCream1 g/100gTopicalNeo Pharm Co., Ltd.2010-09-02Not applicableUs
ClotrimazoleCream1 g/100gTopicalNavarro Discount Pharmacies, LLC2012-08-01Not applicableUs
ClotrimazoleCream10 mg/gTopicalChain Drug Consortium, LLC2003-09-11Not applicableUs
ClotrimazoleCream1 g/100gTopicalTrifecta Pharmaceuticals Usa Llc2015-03-10Not applicableUs
ClotrimazoleCream1 g/100gVaginalTaro Pharmaceuticals U.S.A., Inc.1995-12-04Not applicableUs
ClotrimazoleCream1 g/100gTopicalProficient Rx LP1995-06-01Not applicableUs
ClotrimazoleCream1 g/100gVaginalActavis Pharma, Inc.2003-08-12Not applicableUs
ClotrimazoleCream1 g/100gTopicalKinray Inc.2012-01-11Not applicableUs
ClotrimazoleCream1 g/100gTopicalRebel Distributors Corp1995-06-01Not applicableUs
ClotrimazoleCream10 mg/gTopicalLif Elabs, A Division Of Atico International Usa, Inc.2010-11-01Not applicableUs
ClotrimazoleCream1 g/100gTopicalTaro Pharmaceuticals, Inc.1995-06-01Not applicableUs
ClotrimazoleCream1 g/100gTopicalChain Drug Consortium, LLC2013-10-09Not applicableUs
ClotrimazoleCream10 mg/gTopicalMc Kesson1993-07-19Not applicableUs
ClotrimazoleCream1 g/100gTopicalH.J. Harkins Company, Inc.1995-06-01Not applicableUs
Clotrimazole 1% Athletes FootCream10 mg/gTopicalCVS Pharmacy1993-08-31Not applicableUs
Clotrimazole 7Cream1 g/100gVaginalRite Aid1996-11-22Not applicableUs
Clotrimazole AntifungalCream10 mg/gTopicalArmy and Air Force Exchange Service2006-02-03Not applicableUs
Clotrimazole AntifungalCream10 mg/gTopicalChain Drug Marketing Association Inc.2007-08-29Not applicableUs
Clotrimazole Athletes FootCream10 mg/gTopicalKAISER FOUNDATION HOSPITALS1993-08-31Not applicableUs
Clotrimazole Athletes FootCream10 mg/gTopicalWal Mart Stores, Inc.1993-08-31Not applicableUs
Clotrimazole Cream USP 1%Cream1 %TopicalTaro Pharmaceuticals Inc1996-12-31Not applicableCanada
Clotrimazole External CreamCream1 %TopicalTaro Pharmaceuticals IncNot applicableNot applicableCanada
Clotrimazole Jock ItchCream10 mg/gTopicalWal Mart Stores, Inc.1993-08-31Not applicableUs
Clotrimazole Vaginal Cream USP 1%Cream1 %VaginalTaro Pharmaceuticals Inc2005-04-29Not applicableCanada
Clotrimazole Vaginal Cream USP 2%Cream2 %VaginalTaro Pharmaceuticals Inc1996-12-31Not applicableCanada
Cvs Antifungal RingwormCream1 g/100gTopicalCVS Pharmacy1995-06-01Not applicableUs
Cvs Clotrimazole Maximum StrengthSolution10 mg/mLTopicalCVS Pharmacy2002-02-01Not applicableUs
Cvs Pharmacy Clotrimazole 3Cream2 g/100gVaginalCVS Pharmacy2000-04-12Not applicableUs
Cvs Pharmacy Itch Relief AntifungalCream10 mg/gTopicalCVS Pharmacy1993-08-31Not applicableUs
Cvshealth AntifungalSolution1 mg/mLTopicalCVS Pharmacy2015-11-10Not applicableUs
Dermatin AntifungalCream.01 g/gTopicalMelaleuca, Inc.2011-12-19Not applicableUs
Dr Sheffield Athletes FootCream10 mg/gTopicalFaria Limited dba Sheffield Pharmaceuticals2004-10-04Not applicableUs
Dynarex AntifungalCream1 g/100gTopicalDynarex Corporation2010-05-18Not applicableUs
Equaline Clotrimazole AntifungalCream1 g/100gTopicalSupervalu Inc2011-09-29Not applicableUs
Exchange Select Atheletes FootCream1 g/100gTopicalArmy & Air Force Exchange Service2016-04-07Not applicableUs
Family Care Clotrimazole AntifungalCream1 g/100gTopicalUNITED EXCHANGE CORP.2012-05-01Not applicableUs
Family Wellness AntifungalCream1 g/100gTopicalFamily Dollar2012-04-01Not applicableUs
Family Wellness AntifungalCream10 mg/gTopicalFamily Dollar2014-01-21Not applicableUs
Family Wellness AntifungalCream10 mg/gTopicalFamily Dollar2014-01-20Not applicableUs
FemmesilCream1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2014-11-30Not applicableUs
First Aid Research Antifungal .5ozCream10 mg/gTopicalFirst Aid Research Corp.2014-10-14Not applicableUs
First Aid Research Antifungal Cream 1ozCream10 mg/gTopicalFirst Aid Research Corp.2014-10-14Not applicableUs
Foot Care ClotrimazoleCream10 mg/gTopicalRite Aid2010-03-12Not applicableUs
FootlogixAerosol, spray1 mL/100mLTopicalKVG Group Inc2010-09-01Not applicableUs
Footlogix Intensive Care Diabetic FormulaAerosol, foam1 g/100gTopicalKVG Group Inc2012-06-15Not applicableUs
Forticept Antifungal CoolingLiquid10 g/1000gTopicalCosco International, Inc.2016-05-04Not applicableUs
FortiniaSolution1 g/100mLTopicalThe Podiatree Company2014-10-01Not applicableUs
Fungazoil AdvancedLiquid10 mg/mLTopicalPedifix2014-06-15Not applicableUs
Fungicure IntensiveLiquid10 mg/mLTopicalAlva Amco Pharmacal Companies, Inc.2008-06-05Not applicableUs
Fungicure Liquid GelGel10 mg/gTopicalAlva Amco Pharmacal Companies, Inc.2015-12-31Not applicableUs
Fungicure Manicure PedicureLiquid10 mg/mLTopicalAlva Amco Pharmacal Companies, Inc.2002-07-15Not applicableUs
Fungicure Manicure Pedicure Liquid GelGel10 mg/gTopicalAlva Amco Pharmacal Companies, Inc.2016-07-05Not applicableUs
Fungicure PumpsprayLiquid10 mg/mLTopicalAlva Amco Pharmacal Companies, Inc.2002-03-01Not applicableUs
Fungistat MaxLiquid10 mg/mLTopicalBio Medical & Pharmaceutical Manufacturing Corporation2016-04-12Not applicableUs
Fungistat MaxLiquid10 mg/mLTopicalBio Medical & Pharmaceutical Manufacturing Corporation2016-04-14Not applicableUs
Gehwol Fusskraft Nail and Skin ProtectionSpray4 mg/mLTopicalEduard Gerlach Gmb H2009-06-18Not applicableUs
Gehwol Med FootPowder1 g/100gTopicalEduard Gerlach Gmb H2008-12-04Not applicableUs
Gehwol Nail Protection PenLiquid10 mg/mLTopicalEduard Gerlach Gmb H2008-03-07Not applicableUs
Gerlasan HandCream6 mg/mLTopicalEduard Gerlach Gmb H2008-12-04Not applicableUs
Good Neighbor Pharmacy ClotrimazoleCream10 mg/gTopicalAmerisource Bergen1993-08-31Not applicableUs
Good Neighbor Pharmacy Clotrimazole 3Cream2 g/100gVaginalAmerisource Bergen2000-04-12Not applicableUs
Good Sense Athletes Foot AntifungalCream1 g/100gTopicalL. Perrigo Company2006-04-09Not applicableUs
Gyne-lotrimin 3Cream2 g/100gVaginalMSD Consumer Care, Inc.2002-01-01Not applicableUs
Gyne-lotrimin 7Cream1 g/100gVaginalMSD Consumer Care, Inc.2002-01-01Not applicableUs
Healthy Accents AntifungalCream10 g/gTopicalDZA Brands LLC2016-07-26Not applicableUs
Heb AntifungalCream10 mg/gTopicalH E B1993-08-31Not applicableUs
Hua Tuo Xian GaoOintment1 mg/100gTopicalSHANGHAI SONGHUA PHARMACEUTICAL CO LTD2011-04-28Not applicableUs
JideshengGel1 g/100gTopicalUPC Medical Supplies, Inc.2010-10-23Not applicableUs
JideshengGel1 g/100gTopicalNantong Jidesheng Biology Health Care Products Co., Ltd.2010-10-23Not applicableUs
Jock ItchCream1 g/100gTopicalRite Aid Corporation2005-08-07Not applicableUs
Jock ItchCream1 g/100gTopicalWalgreen Company2014-06-15Not applicableUs
Jock Itch AntifungalCream420 mg/42gTopicalPersonal Care Products, Inc.2013-07-10Not applicableUs
Jock Itch Cream With ClotrimazoleCream1 g/100gTopicalSabel Med Llc2016-05-01Not applicableUs
Kerasal Foot and ToeCream1 g/100gTopicalMOBERG PHARMA NORTH AMERICA LLC2015-01-01Not applicableUs
Kleer-plex Fungistat Athlete Foot CureLiquid10 mg/mLTopicalBio Medical & Pharmaceutical Manufacturing Corporation2015-09-26Not applicableUs
Kleer-plex Fungistat Fungus CureLiquid10 mg/mLTopicalBio Medical & Pharmaceutical Manufacturing Corporation2015-09-29Not applicableUs
Kroger Athletes FootCream10 mg/gTopicalKroger Company1993-08-31Not applicableUs
Kroger Jock ItchCream10 mg/gTopicalKroger Company1993-08-31Not applicableUs
LakesiaCream1 g/100gTopicalOpmx Llc2015-07-02Not applicableUs
Leader Clotrimazole Anti-fungalCream1 g/100gTopicalCardinal Health2013-05-31Not applicableUs
Live Better AntifungalCream10 mg/gTopicalThe Great Atlantic & Pacific Tea Company1993-08-31Not applicableUs
LotriminCream10 mg/gTopicalBayer Health Care Llc2002-02-01Not applicableUs
LotriminCream10 mg/gTopicalBayer Health Care Llc2009-01-02Not applicableUs
Lotrimin AntifungalCream10 mg/gTopicalBayer Health Care Llc2002-02-01Not applicableUs
Lucky Supersoft Athletes FootCream1 g/100gTopicalDelta Brands, Inc2015-01-31Not applicableUs
Major ClotrimazoleCream10 mg/gTopicalMajor Pharmaceuticals2004-10-04Not applicableUs
Major ClotrimazoleCream10 mg/gTopicalREMEDYREPACK INC.2015-04-02Not applicableUs
Major ClotrimazoleCream10 mg/gTopicalClinical Solutions Wholesale2004-10-04Not applicableUs
Major ClotrimazoleCream10 mg/gTopicalCentral Texas Community Health Centers2004-10-04Not applicableUs
MakesenseCream1 g/100gTopicalCherry Hill Sales Co2014-06-15Not applicableUs
Meijer Athletes FootCream10 mg/gTopicalMeijer Distribution Inc1993-08-31Not applicableUs
Meijer Clotrimazole 3Cream2 g/100gVaginalMeijer Distribution Inc2000-04-12Not applicableUs
Meijer Clotrimazole AntifungalCream1 g/100gTopicalMEIJER, INC.2015-01-15Not applicableUs
Myclo Crm 10mgCream10 mgTopicalBoehringer Ingelheim (Canada) Ltd Ltee1981-12-311996-09-09Canada
Myclo Crm 50mgCream50 mgVaginalBoehringer Ingelheim (Canada) Ltd Ltee1981-12-311996-09-09Canada
Myclo SolutionLiquid10 mgTopicalBoehringer Ingelheim (Canada) Ltd Ltee1981-12-311996-09-09Canada
Myclo Tab 100mgSuppository100 mgVaginalBoehringer Ingelheim (Canada) Ltd Ltee1981-12-311996-09-09Canada
Myclo-derm Cream 1%Cream10 mgTopicalBoehringer Ingelheim (Canada) Ltd Ltee1994-12-312000-07-31Canada
Myclo-derm Solution 1%Solution10 mgTopicalBoehringer Ingelheim (Canada) Ltd Ltee1994-12-312000-07-31Canada
Myclo-gyne Cream 1%Cream10 mgTopical; VaginalBoehringer Ingelheim (Canada) Ltd Ltee1994-12-311999-08-09Canada
Myclo-gyne InsertsSuppository100 mgVaginalBoehringer Ingelheim (Canada) Ltd Ltee1994-12-311999-08-09Canada
Neo-zol Cream 1%Cream1 %TopicalPrestige Pharma Inc1990-12-31Not applicableCanada
Neo-zol Vaginal Cream 1%Cream1 %VaginalPrestige Pharma Inc1990-12-31Not applicableCanada
Neo-zol Vaginal Cream 2%Cream2 %VaginalPrestige Pharma Inc1990-12-31Not applicableCanada
Occulus Skin Hydrating Topical Foam Clo-1Aerosol, foam10 mg/gTopicalPrime Packaging, Inc.2015-08-01Not applicableUs
Occulus Skin Hydrating Topical Foam Clo-1 Antifungal FoamAerosol, foam10 mg/gTopicalPrime Packaging, Inc.2015-08-01Not applicableUs
Olp ClotrimazoleCream10 mg/gTopicalOhio Lab Pharma2016-09-01Not applicableUs
Our Family Athletes FootCream10 mg/gTopicalNash Finch Company1993-08-31Not applicableUs
PedesilCream1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2012-09-07Not applicableUs
Pedesil Maximum StrengthOintment1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2012-09-07Not applicableUs
Pro-EX Anti FungalCream.01 g/gTopicalNatureplex, LLC2008-01-22Not applicableUs
Protective and Moisturizing SkinOil10 mg/mLTopicalEduard Gerlach Gmb H2008-12-04Not applicableUs
Protective Nail and SkinCream10 mg/mLTopicalEduard Gerlach Gmb H2008-12-04Not applicableUs
Publix Athletic FootCream10 mg/gTopicalPublix Super Markets Inc1993-08-31Not applicableUs
Quality Choice ClotrimazoleCream10 mg/gTopicalChain Drug Marketing Association2015-01-19Not applicableUs
Rexall Athletes FootCream1 g/100gTopicalDolgencorp LLC2015-05-13Not applicableUs
Rexall Jock ItchCream10 mg/gTopicalDolgencorp, LLC2015-06-22Not applicableUs
Rite Aid Antifungal RingwormCream1 g/100gTopicalRite Aid Corporation1995-06-01Not applicableUs
Scheinpharm Clotrimazole 1%Cream1 %TopicalSchein Pharmaceutical Canada Inc.1997-07-082004-07-26Canada
Shopko Athletes FootCream10 mg/gTopicalShopko Stores Operating Co., LLC1993-08-31Not applicableUs
Shoprite AntifungalCream10 mg/gTopicalWakefern Food Corporation1993-08-31Not applicableUs
Signature Care AntifungalCream10 mg/gTopicalBetter Living Brands Llc2015-08-26Not applicableUs
Signature Care Athletes FootCream1 g/100gTopicalSafeway2015-10-16Not applicableUs
Smart Sense Athletes Foot AntifungalCream1 g/100gTopicalKmart Corporation2010-11-19Not applicableUs
Smooth Gator Fungus EliminatorLiquid10 mg/mLTopicalSmooth Gator, Llc2016-04-29Not applicableUs
Soundbody Clotrimazole AntifungalCream10 mg/gTopicalUNITED EXCHANGE CORP.2014-02-26Not applicableUs
Sunmark AntifungalCream10 mg/gTopicalMc Kesson1993-08-31Not applicableUs
Sunmark Clotrimazole 3Cream2 g/100gVaginalMc Kesson2000-04-12Not applicableUs
Terrasil Anti-fungal TreatmentOintment1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2012-01-26Not applicableUs
Terrasil Anti-fungal Treatment MaxOintment1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2012-09-07Not applicableUs
Terrasil Foot and Nail Anti-fungalCream1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2014-06-26Not applicableUs
Terrasil Foot and Nail Anti-fungal Maximum StrengthOintment1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2014-06-27Not applicableUs
Terrasil Jock-itch Treatment MaxOintment1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2014-05-12Not applicableUs
Terrasil Rapid-clear Anti-fungalKitAidance Skincare & Topical Solutions, LLC2014-04-18Not applicableUs
Terrasil Ringworm Treatment MaxOintment1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2014-05-12Not applicableUs
Terrasil Tinea Treatment MaxOintment1 g/100gTopicalAidance Skincare & Topical Solutions, LLC2014-05-12Not applicableUs
Theraplus PlusCream1 g/100gTopicalZhejiang Jingwei Pharmaceutical Co., Ltd.2013-03-01Not applicableUs
Topcare AntifungalCream10 mg/gTopicalTopco Associates LLC1993-08-31Not applicableUs
Topcare Clotrimazole 3Cream2 g/100gVaginalTopco Associates LLC2000-04-12Not applicableUs
Up and Up Jock Itch ReliefCream1 g/100gTopicalTarget Corporation2013-09-17Not applicableUs
Upandup ClotrimazoleCream10 mg/gTopicalTarget Corporation1993-08-31Not applicableUs
Walgreens ClotrimazoleCream1 g/100gTopicalWalgreen Co2011-04-14Not applicableUs
Walgreens Clotrimazole 3Cream2 g/100gVaginalWalgreen Company2000-04-12Not applicableUs
Walgreens Clotrimazole AntifungalCream1 g/100gTopicalWalgreen Company2015-05-18Not applicableUs
Walgreens Jock ItchCream10 mg/gTopicalWalgreen Company1993-08-31Not applicableUs
Western Family Athletes FootCream10 mg/gTopicalWestern Family Foods Inc1993-08-31Not applicableUs
Winco AntifungalCream10 mg/gTopicalWin Co Foods, Llc2015-02-10Not applicableUs
Zapotol ClotrimazoleCream10 mg/100gTopicalZapotol Corp.2012-08-07Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
CanestenBayer
CanifugDr. August Wolff
ClotrimadermTaro
EmpecidBayer
FemCareNot Available
FungicipCipla
Gyne-LotriminSchering-Plough
MycelexBayer
Myclo-DermNot Available
Myclo-GyneNot Available
Brand mixtures
NameLabellerIngredients
Betamethasone ClotrimazoleStat Rx USA
Canesoral Combi-pakBayer Inc Consumer Care
Canesten 1 Vaginal Tablet Combi-pakBayer Inc Consumer Care
Canesten 3 Vaginal Tablet Combi-pakBayer Inc Consumer Care
Canesten Combi-pak 1 Day TherapyMiles Canada Inc. Consumer Health Care Division
Canesten Combi-pak Comfortab 1Bayer Inc Consumer Care
Canesten Combi-pak Comfortab 3Bayer Inc Consumer Care
Canesten Combi-pak Cream 1Bayer Inc Consumer Care
Clotrimaderm-fluconazole Combi-packTaro Pharmaceuticals Inc
Clotrimazole and Betamethasone DipropionateE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
Clotrimazole-fluconazole Combi-packTaro Pharmaceuticals Inc
Dermacinrx Therazole PakPure Tek Corporation
Lotriderm CreamMerck Canada Inc
LotrisoneMerck Sharp & Dohme Corp.
PMS-clotrimazole-betamethasonePharmascience Inc
SaltsNot Available
Categories
UNIIG07GZ97H65
CAS number23593-75-1
WeightAverage: 344.837
Monoisotopic: 344.108026261
Chemical FormulaC22H17ClN2
InChI KeyVNFPBHJOKIVQEB-UHFFFAOYSA-N
InChI
InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
IUPAC Name
1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole
SMILES
ClC1=CC=CC=C1C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1
Pharmacology
IndicationFor the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
Structured Indications
PharmacodynamicsClotrimazole, an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. In studies in fungal cultures, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. Both of these events began rapidly and extensively after addition of the drug to the cultures. The primary action of clotrimazole is against dividing and growing organisms.
Mechanism of actionClotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Clotrimazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.
TargetKindPharmacological actionActionsOrganismUniProt ID
Lanosterol 14-alpha demethylaseProteinyes
antagonist
inhibitor
YeastP10613 details
Intermediate conductance calcium-activated potassium channel protein 4Proteinyes
inhibitor
HumanO15554 details
Related Articles
AbsorptionPoorly and erratically absorbed orally, minimal vaginal or topical absorption.
Volume of distributionNot Available
Protein binding90%
Metabolism

Hepatic (metabolized to inactive metabolites)

Route of eliminationNot Available
Half life2 hours
ClearanceNot Available
ToxicitySymptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
Affected organisms
  • Yeast and other fungi
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Clotrimazole.Experimental, Illicit
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Clotrimazole.Approved
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Clotrimazole.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Clotrimazole.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Clotrimazole.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Clotrimazole.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Clotrimazole.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Clotrimazole.Approved
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Clotrimazole.Approved
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Clotrimazole.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Clotrimazole.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Clotrimazole.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Clotrimazole.Experimental
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Clotrimazole.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Clotrimazole.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Clotrimazole.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Clotrimazole.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Clotrimazole.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Clotrimazole.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Clotrimazole.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Clotrimazole.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Clotrimazole.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Clotrimazole.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Clotrimazole.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Clotrimazole.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Clotrimazole.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Clotrimazole.Approved
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Clotrimazole.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Clotrimazole.Approved
AmlodipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Amlodipine.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Clotrimazole.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Clotrimazole.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Clotrimazole.Approved, Vet Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Clotrimazole.Approved, Illicit
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Clotrimazole.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Clotrimazole.Approved
AmrinoneThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Amrinone.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Clotrimazole.Approved
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Clotrimazole.Approved
AnilineThe metabolism of Aniline can be decreased when combined with Clotrimazole.Experimental
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Clotrimazole.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Clotrimazole.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Clotrimazole.Approved, Investigational
AprepitantThe metabolism of Aprepitant can be decreased when combined with Clotrimazole.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Clotrimazole.Approved
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Clotrimazole.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Clotrimazole.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Clotrimazole.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Clotrimazole.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Clotrimazole.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Clotrimazole.Approved
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Clotrimazole resulting in a loss in efficacy.Approved
ASA404The metabolism of ASA404 can be decreased when combined with Clotrimazole.Investigational
AsenapineThe metabolism of Asenapine can be decreased when combined with Clotrimazole.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Clotrimazole.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Clotrimazole.Approved, Investigational
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Clotrimazole.Approved
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Clotrimazole.Approved
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Clotrimazole.Approved
AV650The metabolism of AV650 can be decreased when combined with Clotrimazole.Approved, Investigational
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Clotrimazole.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Clotrimazole.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Clotrimazole.Approved
AzelnidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Azelnidipine.Approved
AzimilideThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Azimilide.Investigational
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Clotrimazole.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Clotrimazole.Investigational
BarnidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Barnidipine.Approved
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Clotrimazole.Approved
BendamustineThe metabolism of Bendamustine can be decreased when combined with Clotrimazole.Approved, Investigational
BenidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Benidipine.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Clotrimazole.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Clotrimazole.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Clotrimazole.Approved
BepridilThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Bepridil.Approved, Withdrawn
BeraprostThe metabolism of Beraprost can be decreased when combined with Clotrimazole.Investigational
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Clotrimazole.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Clotrimazole.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Clotrimazole.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Clotrimazole.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Clotrimazole.Approved
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Clotrimazole.Approved
BortezomibThe metabolism of Bortezomib can be decreased when combined with Clotrimazole.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Clotrimazole.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Clotrimazole.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Clotrimazole.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Clotrimazole.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Clotrimazole.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Clotrimazole.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Clotrimazole.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Clotrimazole.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Clotrimazole.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Clotrimazole.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Clotrimazole.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Clotrimazole.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Clotrimazole.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Clotrimazole.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Clotrimazole.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Clotrimazole.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Clotrimazole.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Clotrimazole.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Clotrimazole.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Clotrimazole.Approved
CaiThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Cai.Investigational
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Clotrimazole.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Clotrimazole.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Clotrimazole.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Clotrimazole.Approved
CapsaicinThe metabolism of Capsaicin can be decreased when combined with Clotrimazole.Approved
CaptoprilThe metabolism of Captopril can be decreased when combined with Clotrimazole.Approved
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Clotrimazole.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Clotrimazole.Approved
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Clotrimazole.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Clotrimazole.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Clotrimazole.Approved
CarmustineThe metabolism of Carmustine can be decreased when combined with Clotrimazole.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Clotrimazole.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Clotrimazole.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Clotrimazole.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Clotrimazole.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Clotrimazole.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Clotrimazole.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Clotrimazole.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Clotrimazole.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Clotrimazole.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Clotrimazole.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Clotrimazole.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Clotrimazole.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Clotrimazole.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Clotrimazole.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Clotrimazole.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Clotrimazole.Approved, Investigational
CilnidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Cilnidipine.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Clotrimazole.Approved
CimetidineThe serum concentration of Cimetidine can be decreased when it is combined with Clotrimazole.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Clotrimazole.Approved
CinnarizineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Cinnarizine.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Clotrimazole.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Clotrimazole.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Clotrimazole.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Clotrimazole.Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Clotrimazole.Approved
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClevidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Clevidipine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Clotrimazole.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Clotrimazole.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Clotrimazole.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Clotrimazole.Investigational
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Clotrimazole.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Clotrimazole.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Clotrimazole.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Clotrimazole resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Clotrimazole.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Clotrimazole.Approved, Illicit
ClozapineThe metabolism of Clozapine can be decreased when combined with Clotrimazole.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Clotrimazole.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Clotrimazole.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Clotrimazole.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Clotrimazole.Approved
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Clotrimazole.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Clotrimazole.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Clotrimazole.Approved
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Clotrimazole.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Clotrimazole.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Clotrimazole.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Clotrimazole.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Clotrimazole.Approved
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Clotrimazole.Approved
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Clotrimazole.Approved, Investigational
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Clotrimazole.Approved
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Clotrimazole.Approved
DalfampridineThe metabolism of Dalfampridine can be decreased when combined with Clotrimazole.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Clotrimazole.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Clotrimazole.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Clotrimazole.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Clotrimazole.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Clotrimazole.Approved, Investigational
DarodipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Darodipine.Experimental
DarunavirThe metabolism of Darunavir can be decreased when combined with Clotrimazole.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Clotrimazole.Approved
DasatinibThe metabolism of Dasatinib can be decreased when combined with Clotrimazole.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Clotrimazole.Approved
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Clotrimazole.Approved
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Clotrimazole.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Clotrimazole.Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Clotrimazole.Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Clotrimazole.Approved, Illicit, Withdrawn
DexmedetomidineThe metabolism of Dexmedetomidine can be decreased when combined with Clotrimazole.Approved, Vet Approved
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Clotrimazole.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Clotrimazole.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Clotrimazole.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Clotrimazole.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Clotrimazole.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Clotrimazole.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Clotrimazole.Approved
DidanosineDidanosine can cause a decrease in the absorption of Clotrimazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Clotrimazole.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Clotrimazole.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Clotrimazole.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Clotrimazole.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Clotrimazole.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Clotrimazole.Illicit
DiltiazemThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Diltiazem.Approved
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Clotrimazole.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Clotrimazole.Approved
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Clotrimazole.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Clotrimazole.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Clotrimazole.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Clotrimazole.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be decreased when combined with Clotrimazole.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Clotrimazole.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Clotrimazole.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Clotrimazole.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Clotrimazole.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Clotrimazole.Approved
DotarizineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Dotarizine.Investigational
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Clotrimazole.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Clotrimazole.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Clotrimazole.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Clotrimazole.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Clotrimazole.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Clotrimazole.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Clotrimazole.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Clotrimazole.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Clotrimazole.Approved
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Clotrimazole.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Efonidipine.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Clotrimazole.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Clotrimazole.Approved
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Clotrimazole.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Clotrimazole.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Clotrimazole.Approved, Vet Approved
EncainideThe metabolism of Encainide can be decreased when combined with Clotrimazole.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Clotrimazole.Investigational
EnfluraneThe metabolism of Enflurane can be decreased when combined with Clotrimazole.Approved, Vet Approved
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Clotrimazole.Approved, Investigational
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Clotrimazole.Approved
EperisoneThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Eperisone.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Clotrimazole.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Clotrimazole.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Clotrimazole.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Clotrimazole.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Clotrimazole.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Clotrimazole.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Clotrimazole.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Clotrimazole.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Clotrimazole.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Clotrimazole.Approved, Investigational
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Clotrimazole.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Clotrimazole.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Clotrimazole.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Clotrimazole.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Clotrimazole.Approved
EstriolThe serum concentration of Estriol can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Clotrimazole.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Clotrimazole.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Clotrimazole.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Clotrimazole.Approved
Ethanolamine OleateThe metabolism of Ethanolamine Oleate can be decreased when combined with Clotrimazole.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Clotrimazole.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Clotrimazole.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Clotrimazole.Approved, Illicit
EtodolacThe metabolism of Etodolac can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Clotrimazole.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Clotrimazole.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Clotrimazole.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Clotrimazole.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Clotrimazole.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Clotrimazole.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Clotrimazole.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Clotrimazole.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Clotrimazole.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Clotrimazole.Approved
FelodipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Felodipine.Approved, Investigational
FendilineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Fendiline.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Clotrimazole.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Clotrimazole.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Clotrimazole.Approved
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Clotrimazole.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Clotrimazole.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Clotrimazole.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Clotrimazole.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Clotrimazole.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Clotrimazole.Approved
FlunarizineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Flunarizine.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Clotrimazole.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Clotrimazole.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Clotrimazole.Approved
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Clotrimazole.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Clotrimazole.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Clotrimazole.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Clotrimazole.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Clotrimazole.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Clotrimazole.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Clotrimazole.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Clotrimazole.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Clotrimazole.Approved
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Clotrimazole.Approved, Investigational
Folic AcidThe metabolism of Folic Acid can be decreased when combined with Clotrimazole.Approved, Nutraceutical, Vet Approved
FormoterolThe metabolism of Formoterol can be decreased when combined with Clotrimazole.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Clotrimazole.Approved
FosphenytoinThe serum concentration of Clotrimazole can be decreased when it is combined with Fosphenytoin.Approved
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Clotrimazole.Approved, Investigational
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Clotrimazole.Approved, Investigational
GabapentinThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Gabapentin.Approved, Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Clotrimazole.Approved
GallopamilThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Gallopamil.Investigational
GavestinelThe metabolism of Gavestinel can be decreased when combined with Clotrimazole.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Clotrimazole.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Clotrimazole.Approved
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Clotrimazole.Approved
GenisteinThe metabolism of Genistein can be decreased when combined with Clotrimazole.Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Clotrimazole.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Clotrimazole.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Clotrimazole.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Clotrimazole.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Clotrimazole.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Clotrimazole.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Clotrimazole.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Clotrimazole.Withdrawn
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Clotrimazole.Approved
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Clotrimazole.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Clotrimazole.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Clotrimazole.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Clotrimazole.Approved, Vet Approved
HesperetinThe metabolism of Hesperetin can be decreased when combined with Clotrimazole.Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Clotrimazole.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Clotrimazole.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Clotrimazole.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Clotrimazole.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Clotrimazole.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Clotrimazole.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Clotrimazole.Approved
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Clotrimazole.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Clotrimazole.Approved
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Clotrimazole.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Clotrimazole resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Clotrimazole.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Clotrimazole.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Clotrimazole.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Clotrimazole.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Clotrimazole.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Clotrimazole.Approved
IndinavirThe metabolism of Indinavir can be decreased when combined with Clotrimazole.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Clotrimazole.Investigational
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Clotrimazole.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Clotrimazole.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Clotrimazole.Approved, Investigational
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Clotrimazole.Approved, Investigational
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Clotrimazole.Approved, Investigational
IsofluraneThe metabolism of Isoflurane can be decreased when combined with Clotrimazole.Approved, Vet Approved
IsoniazidThe metabolism of Isoniazid can be decreased when combined with Clotrimazole.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Clotrimazole.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Clotrimazole.Approved
IsradipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Isradipine.Approved
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Clotrimazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Clotrimazole.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Clotrimazole.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Clotrimazole.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Clotrimazole.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Clotrimazole.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Clotrimazole.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Clotrimazole.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Clotrimazole.Approved
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Clotrimazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Clotrimazole.Approved, Vet Approved
LabetalolThe metabolism of Labetalol can be decreased when combined with Clotrimazole.Approved
LacidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Lacidipine.Approved
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Clotrimazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Lamotrigine.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Clotrimazole.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Clotrimazole.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Clotrimazole.Investigational
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Clotrimazole.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Clotrimazole.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Clotrimazole.Approved
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Clotrimazole.Approved
LercanidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Lercanidipine.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Clotrimazole.Approved
LetrozoleThe metabolism of Letrozole can be decreased when combined with Clotrimazole.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Clotrimazole.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Clotrimazole.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Clotrimazole.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Clotrimazole.Approved
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Clotrimazole.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Clotrimazole.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Clotrimazole.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Clotrimazole.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Clotrimazole.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Clotrimazole.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Clotrimazole.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Clotrimazole.Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Clotrimazole.Approved
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Clotrimazole.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Clotrimazole.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Clotrimazole.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Clotrimazole.Approved
LopinavirThe metabolism of Lopinavir can be decreased when combined with Clotrimazole.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Clotrimazole.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Clotrimazole.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Clotrimazole.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Clotrimazole.Approved
LovastatinThe metabolism of Lovastatin can be decreased when combined with Clotrimazole.Approved, Investigational
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Clotrimazole.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Clotrimazole.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Clotrimazole.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Clotrimazole.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Magnesium Sulfate.Approved, Vet Approved
MalathionThe metabolism of Malathion can be decreased when combined with Clotrimazole.Approved, Investigational
ManidipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Manidipine.Approved
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Clotrimazole.Approved, Investigational
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Clotrimazole.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Clotrimazole.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Clotrimazole.Approved, Investigational
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Clotrimazole.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Clotrimazole.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Clotrimazole.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Clotrimazole.Approved, Vet Approved
MenadioneThe metabolism of Menadione can be decreased when combined with Clotrimazole.Approved, Nutraceutical
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Clotrimazole.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Clotrimazole.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Clotrimazole.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Clotrimazole.Approved
MestranolThe metabolism of Mestranol can be decreased when combined with Clotrimazole.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Clotrimazole.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Clotrimazole.Approved, Illicit
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Clotrimazole.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Clotrimazole.Approved
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Clotrimazole.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Clotrimazole.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Clotrimazole.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Clotrimazole.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Clotrimazole.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Clotrimazole.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Clotrimazole.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Clotrimazole.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Clotrimazole.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Clotrimazole.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Clotrimazole.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Clotrimazole.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Clotrimazole.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Clotrimazole.Approved
MibefradilThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Mibefradil.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Clotrimazole.Approved, Illicit
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Clotrimazole.Approved, Investigational
MinaprineThe metabolism of Minaprine can be decreased when combined with Clotrimazole.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Clotrimazole.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Clotrimazole.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Clotrimazole.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Clotrimazole.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Clotrimazole.Approved, Investigational
MontelukastThe metabolism of Montelukast can be decreased when combined with Clotrimazole.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Clotrimazole.Approved, Investigational
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Clotrimazole.Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Clotrimazole.Approved, Investigational
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Clotrimazole.Approved
NadololThe serum concentration of Nadolol can be decreased when it is combined with Clotrimazole.Approved
NaftopidilThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Naftopidil.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Clotrimazole.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Clotrimazole.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Clotrimazole.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Clotrimazole.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Clotrimazole.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Clotrimazole.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Clotrimazole.Approved
NetupitantThe metabolism of Netupitant can be decreased when combined with Clotrimazole.Approved
NevirapineThe metabolism of Nevirapine can be decreased when combined with Clotrimazole.Approved
NicardipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nicardipine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Clotrimazole.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Clotrimazole.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Clotrimazole.Approved
NifedipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nifedipine.Approved
NiguldipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Niguldipine.Experimental
NilotinibThe metabolism of Nilotinib can be decreased when combined with Clotrimazole.Approved, Investigational
NiludipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Niludipine.Experimental
NilutamideThe metabolism of Nilutamide can be decreased when combined with Clotrimazole.Approved
NilvadipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nilvadipine.Approved
NimesulideThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nimesulide.Approved, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Clotrimazole.Approved
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Clotrimazole.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nisoldipine.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Clotrimazole.Approved
NitrendipineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Nitrendipine.Approved
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Clotrimazole.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Clotrimazole.Approved, Vet Approved
NizatidineThe serum concentration of Nizatidine can be decreased when it is combined with Clotrimazole.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Clotrimazole.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Clotrimazole.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Clotrimazole.Approved
OlanzapineThe serum concentration of Olanzapine can be decreased when it is combined with Clotrimazole.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Clotrimazole.Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Clotrimazole.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Clotrimazole.Approved
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Clotrimazole.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Clotrimazole.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Clotrimazole.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Clotrimazole.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Clotrimazole.Approved
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Clotrimazole.Approved, Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Clotrimazole.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Clotrimazole.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Clotrimazole.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Clotrimazole.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Clotrimazole.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Clotrimazole.Approved, Vet Approved
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Clotrimazole.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Clotrimazole.Approved, Investigational
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Clotrimazole.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Clotrimazole.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Clotrimazole.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Clotrimazole.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Clotrimazole.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Clotrimazole.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Clotrimazole.Approved
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Clotrimazole.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Clotrimazole.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Clotrimazole.Approved
PentobarbitalThe metabolism of Pentobarbital can be decreased when combined with Clotrimazole.Approved, Vet Approved
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Clotrimazole.Approved, Investigational
PerampanelThe metabolism of Perampanel can be decreased when combined with Clotrimazole.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Clotrimazole.Approved, Vet Approved, Withdrawn
PerhexilineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Perhexiline.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Clotrimazole.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Clotrimazole.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Clotrimazole.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Clotrimazole.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Clotrimazole.Approved, Withdrawn
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Clotrimazole.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Clotrimazole.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Clotrimazole.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Clotrimazole.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Clotrimazole.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Clotrimazole.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Clotrimazole.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Clotrimazole.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Clotrimazole.Withdrawn
PinaveriumThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Pinaverium.Approved
PindololThe metabolism of Pindolol can be decreased when combined with Clotrimazole.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Clotrimazole.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Clotrimazole.Approved
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Clotrimazole.Investigational
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Clotrimazole.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Clotrimazole.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Clotrimazole.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Clotrimazole.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Clotrimazole.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Clotrimazole.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Clotrimazole.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Clotrimazole.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Clotrimazole.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Clotrimazole.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Clotrimazole.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Clotrimazole.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Clotrimazole.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Pregabalin.Approved, Illicit, Investigational
PrenylamineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Prenylamine.Withdrawn
PrimaquineThe metabolism of Primaquine can be decreased when combined with Clotrimazole.Approved
PrimidoneThe metabolism of Primidone can be decreased when combined with Clotrimazole.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Clotrimazole.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ProgesteroneThe therapeutic efficacy of Progesterone can be decreased when used in combination with Clotrimazole.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Clotrimazole.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Clotrimazole.Approved
PropafenoneThe serum concentration of Clotrimazole can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Clotrimazole.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Clotrimazole.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Clotrimazole.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Clotrimazole.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Clotrimazole.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Clotrimazole.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Clotrimazole.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Clotrimazole.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Clotrimazole.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Clotrimazole.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Clotrimazole.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Clotrimazole.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Clotrimazole.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be decreased when it is combined with Clotrimazole.Approved
RanolazineThe metabolism of Ranolazine can be decreased when combined with Clotrimazole.Approved, Investigational
RasagilineThe metabolism of Rasagiline can be decreased when combined with Clotrimazole.Approved
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Clotrimazole.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Clotrimazole.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Clotrimazole.Approved, Withdrawn
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Clotrimazole.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Clotrimazole.Investigational
ReserpineThe serum concentration of Reserpine can be decreased when it is combined with Clotrimazole.Approved
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Clotrimazole.Experimental, Investigational
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Clotrimazole.Approved
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Clotrimazole.Approved
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Clotrimazole.Approved
RifapentineThe serum concentration of Rifapentine can be increased when it is combined with Clotrimazole.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Clotrimazole.Approved, Investigational
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Clotrimazole.Approved
RiluzoleThe metabolism of Riluzole can be decreased when combined with Clotrimazole.Approved, Investigational
RimonabantThe metabolism of Rimonabant can be decreased when combined with Clotrimazole.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Clotrimazole.Approved
RisedronateThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Risedronate.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be decreased when combined with Clotrimazole.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Clotrimazole.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Clotrimazole.Approved
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Clotrimazole.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Clotrimazole.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Clotrimazole.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Clotrimazole.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Clotrimazole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Clotrimazole.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Clotrimazole.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Clotrimazole.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Clotrimazole.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Clotrimazole.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Clotrimazole.Approved
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Clotrimazole.Approved
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Clotrimazole.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Clotrimazole.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Clotrimazole.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Clotrimazole.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Clotrimazole.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Clotrimazole.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Clotrimazole.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Clotrimazole.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be decreased when combined with Clotrimazole.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Clotrimazole.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Clotrimazole.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Clotrimazole.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Clotrimazole.Approved, Investigational
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Clotrimazole.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Clotrimazole.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Clotrimazole.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Clotrimazole.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Clotrimazole.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Clotrimazole.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Clotrimazole.Approved
SparteineThe metabolism of Sparteine can be decreased when combined with Clotrimazole.Experimental
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Clotrimazole.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Clotrimazole.Approved
SucralfateSucralfate can cause a decrease in the absorption of Clotrimazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Clotrimazole.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Clotrimazole.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Clotrimazole.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Clotrimazole.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Clotrimazole.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Clotrimazole.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Clotrimazole.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Clotrimazole.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Clotrimazole.Approved
TacrineThe metabolism of Tacrine can be decreased when combined with Clotrimazole.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Clotrimazole.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Clotrimazole.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Clotrimazole.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Clotrimazole resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Clotrimazole.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Clotrimazole.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Clotrimazole.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Clotrimazole.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Clotrimazole.Experimental
TazaroteneThe metabolism of Tazarotene can be decreased when combined with Clotrimazole.Approved, Investigational
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Clotrimazole.Approved
TegafurThe serum concentration of the active metabolites of Tegafur can be reduced when Tegafur is used in combination with Clotrimazole resulting in a loss in efficacy.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Clotrimazole.Investigational, Withdrawn
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Clotrimazole.Approved
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Clotrimazole.Approved
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Clotrimazole.Withdrawn
TemazepamThe metabolism of Temazepam can be decreased when combined with Clotrimazole.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Clotrimazole.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Clotrimazole.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Clotrimazole.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Clotrimazole.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Clotrimazole.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Clotrimazole.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Clotrimazole.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Clotrimazole.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Clotrimazole.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
TheobromineThe metabolism of Theobromine can be decreased when combined with Clotrimazole.Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Clotrimazole.Approved
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Clotrimazole.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Clotrimazole.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Clotrimazole.Approved
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Clotrimazole.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Clotrimazole.Approved
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Clotrimazole.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Clotrimazole.Approved
TimololThe serum concentration of Timolol can be decreased when it is combined with Clotrimazole.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Clotrimazole.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Clotrimazole.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Clotrimazole.Approved, Investigational
TirapazamineThe metabolism of Tirapazamine can be decreased when combined with Clotrimazole.Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Clotrimazole.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Clotrimazole.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Clotrimazole.Approved
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Tolfenamic Acid.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Clotrimazole.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Clotrimazole.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Clotrimazole.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Clotrimazole.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Clotrimazole.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Clotrimazole.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Clotrimazole.Approved, Investigational
TranilastThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Tranilast.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Clotrimazole.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Clotrimazole.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Clotrimazole.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Clotrimazole.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Clotrimazole.Approved, Vet Approved
TriamtereneThe metabolism of Triamterene can be decreased when combined with Clotrimazole.Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Clotrimazole.Approved
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Clotrimazole.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Clotrimazole.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Clotrimazole.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Clotrimazole.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Clotrimazole.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Clotrimazole.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Clotrimazole.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Clotrimazole.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Clotrimazole.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Clotrimazole.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Clotrimazole.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Clotrimazole.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Clotrimazole.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Clotrimazole.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Clotrimazole.Approved
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Clotrimazole.Approved
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Clotrimazole.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Clotrimazole.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Clotrimazole.Approved
VerapamilThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Verapamil.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Clotrimazole.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Clotrimazole.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Clotrimazole.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Clotrimazole.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Clotrimazole.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Clotrimazole.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Clotrimazole.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Clotrimazole.Approved, Investigational
VinpocetineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Vinpocetine.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Clotrimazole.Approved
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Clotrimazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Clotrimazole.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Clotrimazole.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
XylometazolineThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Xylometazoline.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Clotrimazole.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Clotrimazole.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Clotrimazole.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Clotrimazole.Approved
ZiconotideThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Ziconotide.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Clotrimazole.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Clotrimazole.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Clotrimazole.Approved
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Clotrimazole.Approved, Investigational
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Clotrimazole.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Clotrimazole.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Clotrimazole.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Clotrimazole.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Clotrimazole.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

Buechel, K.H., et al; South African Patent 69/0039; January 3, 1969; assigned to Farben- Buechel, K.H., Regel, E. and Plempel, M.; US. Patent 3,660,577; May 2,1972; and U.S. fabriken Bayer AG, Germany.
Patent 3,705,172; Dec. 5,1972; both assigned to Farbenfabriken Bayer A.G. (Germany).

US3705172
General ReferencesNot Available
External Links
ATC CodesD01AC01G01AF02A01AB18
AHFS Codes
  • 84:04.08.08
PDB EntriesNot Available
FDA labelDownload (139 KB)
MSDSDownload (73.8 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9725
Blood Brain Barrier+0.9837
Caco-2 permeable+0.6858
P-glycoprotein substrateNon-substrate0.7185
P-glycoprotein inhibitor INon-inhibitor0.6612
P-glycoprotein inhibitor IINon-inhibitor0.7884
Renal organic cation transporterNon-inhibitor0.5854
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9149
CYP450 3A4 substrateNon-substrate0.6262
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorInhibitor0.8948
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorInhibitor0.8478
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9799
Ames testNon AMES toxic0.7428
CarcinogenicityNon-carcinogens0.9018
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.7194 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9659
hERG inhibition (predictor II)Inhibitor0.6779
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Schering plough healthcare products inc
  • Bayer pharmaceuticals corp
  • Glenmark pharmaceuticals inc usa
  • Nycomed us inc
  • Taro pharmaceuticals usa inc
  • Actavis mid atlantic llc
  • Taro pharmaceuticals inc
  • Schering corp sub schering plough corp
  • Teva pharmaceuticals usa inc
  • Bayer healthcare pharmaceuticals inc
  • Teva pharmaceuticals usa
  • Paddock laboratories inc
  • Roxane laboratories inc
Packagers
Dosage forms
FormRouteStrength
OintmentTopical10 mg/g
CreamTopical350 mg/35g
CreamTopical.01 g/g
Capsule; creamOral; Topical; Vaginal
SolutionTopical1 %
CreamTopical; Vaginal2 %
SuppositoryVaginal200 mg
Cream; suppositoryTopical; Vaginal
Cream; tabletTopical; Vaginal
CreamTopical; Vaginal
TabletVaginal500 mg
TabletVaginal200 mg
CreamVaginal10 %
CreamVaginal2 %
CreamVaginal1 %
CreamTopical; Vaginal1 %
CreamTopical1 %
LiquidTopical1 %
SuppositoryVaginal100 mg
CreamTopical1 g/g
Capsule; cream; kitOral; Topical
CreamTopical10 mg/g
CreamTopical50 mg/g
CreamVaginal1 g/100g
LiquidTopical1 mg/mL
LozengeOral10 mg/1
LozengeOral; Topical10 mg/1
SolutionTopical1 g/mL
SolutionTopical10 mg/mL
LotionTopical
SolutionTopical1 mg/mL
Kit
Aerosol, sprayTopical1 mL/100mL
Aerosol, foamTopical1 g/100g
LiquidTopical10 g/1000g
SolutionTopical1 g/100mL
GelTopical10 mg/g
SprayTopical4 mg/mL
PowderTopical1 g/100g
CreamTopical6 mg/mL
CreamTopical10 g/g
OintmentTopical1 mg/100g
GelTopical1 g/100g
CreamTopical1 g/100g
CreamTopical420 mg/42g
LiquidTopical10 mg/mL
CreamTopical
CreamVaginal50 mg
LiquidTopical10 mg
CreamTopical10 mg
SolutionTopical10 mg
CreamTopical; Vaginal10 mg
Aerosol, foamTopical10 mg/g
OilTopical10 mg/mL
CreamTopical10 mg/mL
OintmentTopical1 g/100g
Kit
CreamVaginal2 g/100g
CreamTopical10 mg/100g
Prices
Unit descriptionCostUnit
Clotrimazole 70 10 mg Troche Bottle117.04USD bottle
Clotrimazole 1% Cream 45 gm Tube49.99USD tube
Clotrimazole 1% Cream 30 gm Tube35.99USD tube
Clotrimazole 1% Solution 30ml Bottle24.99USD bottle
Clotrimazole 1% Cream 15 gm Tube17.99USD tube
Clotrimazole 1% Solution 10ml Bottle17.99USD bottle
Clotrimazole powder5.2USD g
Mycelex 10 mg troche1.85USD troche
Clotrimazole 10 mg troche1.61USD troche
Mycelex-7 100 mg vaginal tablet1.33USD tablet
Lotrimin 1% cream1.28USD g
Gyne-lotrimin insert1.03USD insert
Mycelex 1% cream0.9USD g
Clotrimazole insert0.86USD insert
Lotrimin ultra 1% cream0.68USD g
Clotrimazole 1% cream0.53USD g
Clotrimazole 3 2% cream0.5USD g
Ra clotrimazole 3 cream0.46USD g
Ra athlete's 1% foot cream0.37USD g
Desenex 1% cream0.33USD g
CVS Pharmacy clotrimazole 1% cream0.32USD g
Antifungal 1% cream0.27USD g
Sm antifungal 1% cream0.25USD g
Ra clotrimazole af cream0.24USD g
Clotrim 1% vaginal cream0.18USD g
Lotrimin af 2% spray powder0.05USD g
Lotrimin af 2% liquid spray0.04USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point154-156Buechel, K.H., et al; South African Patent 69/0039; January 3, 1969; assigned to Farben- Buechel, K.H., Regel, E. and Plempel, M.; US. Patent 3,660,577; May 2,1972; and U.S. fabriken Bayer AG, Germany. Patent 3,705,172; Dec. 5,1972; both assigned to Farbenfabriken Bayer A.G. (Germany).
water solubility29.84 mg/mLNot Available
logP6.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00147 mg/mLALOGPS
logP5.48ALOGPS
logP5.84ChemAxon
logS-5.4ALOGPS
pKa (Strongest Basic)6.62ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area17.82 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity103.76 m3·mol-1ChemAxon
Polarizability36.25 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-004i-0090000000-9ac001e37a55e61bc916View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-004i-0290000000-6285150b307e50af52c7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-016u-0690000000-5814802384fae84ca3dfView in MoNA
MSMass Spectrum (Electron Ionization)splash10-004i-1490000000-442fa75d6a2d80321e36View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as chlorobenzenes. These are compounds containing one or more chlorine atoms attached to a benzene moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassHalobenzenes
Direct ParentChlorobenzenes
Alternative Parents
Substituents
  • Chlorobenzene
  • N-substituted imidazole
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Imidazole
  • Azole
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
antagonistinhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
ERG11
Uniprot ID:
P10613
Molecular Weight:
60674.965 Da
References
  1. Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL: Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45. doi: 10.1128/AAC.00587-10. Epub 2010 Jul 12. [PubMed:20625155 ]
  2. Gachotte D, Pierson CA, Lees ND, Barbuch R, Koegel C, Bard M: A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11173-8. [PubMed:9326581 ]
  3. Henry KW, Nickels JT, Edlind TD: Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother. 2000 Oct;44(10):2693-700. [PubMed:10991846 ]
  4. Lorenz RT, Parks LW: Physiological effects of fenpropimorph on wild-type Saccharomyces cerevisiae and fenpropimorph-resistant mutants. Antimicrob Agents Chemother. 1991 Aug;35(8):1532-7. [PubMed:1929324 ]
  5. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Protein phosphatase binding
Specific Function:
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMe...
Gene Name:
KCNN4
Uniprot ID:
O15554
Molecular Weight:
47695.12 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Brugnara C, Gee B, Armsby CC, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS: Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1996 Mar 1;97(5):1227-34. [PubMed:8636434 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Kao J, King SP, Miwa G, Ni L, Kumar G, McLeod J, Obach SR, Roberts S, Roe A, Shah A, Snikeris F, Sullivan JT, Tweedie D, Vega JM, Walsh J, Wrighton SA: The conduct of in vitro and in vivo drug-drug interaction studies: a PhRMA perspective. J Clin Pharmacol. 2003 May;43(5):443-69. [PubMed:12751267 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. [PubMed:17101742 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name:
CYP11A1
Uniprot ID:
P05108
Molecular Weight:
60101.87 Da
References
  1. Mason JI, Murry BA, Olcott M, Sheets JJ: Imidazole antimycotics: inhibitors of steroid aromatase. Biochem Pharmacol. 1985 Apr 1;34(7):1087-92. [PubMed:3921030 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Gene Name:
CYP19A1
Uniprot ID:
P11511
Molecular Weight:
57882.48 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Organic anion transmembrane transporter activity
Specific Function:
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
Gene Name:
ABCC3
Uniprot ID:
O15438
Molecular Weight:
169341.14 Da
References
  1. Teng S, Jekerle V, Piquette-Miller M: Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. [PubMed:14570758 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. [PubMed:11297522 ]
  2. Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. [PubMed:8632764 ]
  3. Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. [PubMed:11961113 ]
  4. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  5. Bain LJ, LeBlanc GA: Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein. Toxicol Appl Pharmacol. 1996 Nov;141(1):288-98. [PubMed:8917702 ]
  6. Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. [PubMed:12235267 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Kauffmann HM, Pfannschmidt S, Zoller H, Benz A, Vorderstemann B, Webster JI, Schrenk D: Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46. [PubMed:11836020 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23