Impaired Renal Function

Also known as: Renal impairment / Renal Insufficiency / Renal Impairments / Insufficiency renal / Renal impairment NOS

DrugDrug NameDrug Description
DB08898GlucarpidaseGlucarpidase is the recombinant form of the Pseudomonas sp. (strain RS-16) enzyme carboxypeptidase G2 that is produced in Escherichia coli. In patients, glucarpidase inactivates methotrexate, and other antifolates, by hydrolyzing glutamate on the carboxyl terminal of these compounds. Therefore since methotrexate is eliminated enzymatically and not by the kidneys, glucarpidase is indicated in patients on methotrexate treatment who have kidney dysfunction, and are experiencing an abnormally high plasma concentration of methotrexate (>1 micromole per liter). Glucarpidase is marketed under the brand name Voraxaze®.
DrugDrug NameTargetType
DB08898GlucarpidaseMethotrexatetarget
DrugDrug NamePhaseStatusCount
DB11804AZD-56721Completed1
DB09043Albiglutide1Completed1
DB01076Atorvastatin1Not Yet Recruiting1
DB06681Belatacept1Active Not Recruiting1
DB09258Bemiparin1Completed1
DB12364Betrixaban1Completed1
DB12464Bevenopran1Terminated1
DB11666Buparlisib1Completed1
DB05153Cabozantinib1Completed1
DB08875Cabozantinib1Completed1
DB08907Canagliflozin1Completed1
DB09061Cannabidiol1Withdrawn1
DB01413Cefepime1Completed1
DB01413Cefepime1Recruiting1
DB11777Cenderitide1Withdrawn1
DB01432Cholestyramine1Completed1
DB11890Cilengitide1Completed1
DB00515Cisplatin1Completed1
DB08865Crizotinib1Completed1
DB00531Cyclophosphamide1Completed1
DB06695Dabigatran etexilate1Completed1
DB08912Dabrafenib1Recruiting1
DB13120Deferitazole1Completed1
DB11921Deflazacort1Completed1
DB06643Denosumab1Completed1
DB01234Dexamethasone1Active Not Recruiting1
DB11807Dexmecamylamine1Completed1
DB01248Docetaxel1Not Yet Recruiting1
DB12301Doravirine1Completed1
DB00470Dronabinol1Withdrawn1
DB12243Edaravone1Recruiting1
DB11574Elbasvir1Completed1
DB06210Eltrombopag1Completed1
DB05408Emricasan1Completed1
DB11726Encenicline1Completed1
DB11841Entinostat1Recruiting1
DB11827Ertugliflozin1Completed1
DB00199Erythromycin1Completed1
DB11823Esketamine1Recruiting1
DB12625Evogliptin1Completed1
DB11808Faldaprevir1Terminated1
DB12500Fedratinib1Completed1
DB12011Fevipiprant1Not Yet Recruiting1
DB09279Fimasartan1Completed1
DB08868Fingolimod1Completed1
DB00569Fondaparinux sodium1Completed1
DB12010Fostamatinib1Completed1
DB11796Fostemsavir1Completed1
DB00695Furosemide1Terminated1
DB13879Glecaprevir1Completed1
DB06583Glycopyrronium1Completed1
DB11575Grazoprevir1Completed1
DB00956Hydrocodone1Completed1
DB12105Imagabalin1Terminated1
DB06218Lacosamide1Completed1
DB09078Lenvatinib1Completed1
DB09198Lobeglitazone1Completed1
DB04871Lorcaserin1Completed1
DB11968MK-71451Terminated1
DB11968MK-71451Withdrawn1
DB06800Methylnaltrexone1Completed1
DB00683Midazolam1Not Yet Recruiting1
DB08893Mirabegron1Completed1
DB11792Mirodenafil1Completed1
DB06230Nalmefene1Completed1
DB00238Nevirapine1Completed1
DB13041Odalasvir1Recruiting1
DB06670Odanacatib1Completed1
DB11837Osilodrostat1Completed1
DB09073Palbociclib1Completed1
DB06663Pasireotide1Completed1
DB00022Peginterferon alfa-2b1Completed1
DB09122Peginterferon beta-1a1Completed1
DB00191Phentermine1Completed1
DB08860Pitavastatin1Not Yet Recruiting1
DB11642Pitolisant1Completed1
DB06809Plerixafor1Completed1
DB08910Pomalidomide1Active Not Recruiting1
DB00468Quinine1Terminated1
DB11730Ribociclib1Recruiting1
DB01045Rifampicin1Not Yet Recruiting1
DB00073Rituximab1Active Not Recruiting1
DB06228Rivaroxaban1Completed1
DB12778Rivipansel1Recruiting1
DB01098Rosuvastatin1Not Yet Recruiting1
DB04847Roxadustat1Completed1
DB04847Roxadustat1Recruiting1
DB06654Safinamide1Completed1
DB13928Semaglutide1Completed1
DB12371Siponimod1Completed1
DB11159Sodium sulfide1Terminated1
DB12713Sotagliflozin1Active Not Recruiting1
DB06206Sugammadex1Completed1
DB00864Tacrolimus1Completed1
DB05359Tasimelteon1Completed1
DB09071Tasimelteon1Completed1
DB09042Tedizolid Phosphate1Completed1
DB08900Teduglutide1Completed1
DB04902Ticagrelor1Completed1
DB08816Ticagrelor1Completed1
DB01409Tiotropium1Completed1
DB00775Tirofiban1Completed1
DB08895Tofacitinib1Completed1
DB00214Torasemide1Terminated1
DB12056Trebananib1Completed1
DB06267Udenafil1Completed1
DB12164Varespladib methyl1Terminated1
DB11777Cenderitide1 / 2Completed1
DB11121Chloroxylenol1 / 2Completed1
DB05253Proellex1 / 2Terminated1
DB11855Revefenacin1 / 2Completed1
DB00820Tadalafil1 / 2Recruiting2
DB04876Vildagliptin1 / 2Completed1
DB06151Acetylcysteine2Completed1
DB08889Carfilzomib2Completed1
DB09102Daclatasvir2Withdrawn1
DB04854Febuxostat2Completed1
DB05059ILY1012Unknown Status1
DB00480Lenalidomide2Completed1
DB04899Nesiritide2Completed1
DB06290Simeprevir2Withdrawn1
DB09153Sodium Chloride2Completed1
DB01390Sodium bicarbonate2Completed1
DB12569Tonapofylline2Terminated1
DB12353Ulodesine2Completed1
DB06779Dalteparin2 / 3Completed1
DB05640Tonapofylline2 / 3Completed1
DB12569Tonapofylline2 / 3Completed1
DB06605Apixaban3Recruiting1
DB01076Atorvastatin3Active Not Recruiting1
DB01076Atorvastatin3Completed1
DB00074Basiliximab3Completed1
DB08907Canagliflozin3Completed1
DB11723Dutogliptin3Terminated1
DB09038Empagliflozin3Completed1
DB08917Ferric Carboxymaltose3Completed1
DB09162Ferric Citrate3Recruiting1
DB00828Fosfomycin3Completed1
DB00695Furosemide3Completed2
DB01109Heparin3Recruiting1
DB05059ILY1013Completed3
DB09146Iron saccharate3Completed1
DB00583L-Carnitine3Terminated1
DB00678Losartan3Completed1
DB00688Mycophenolate mofetil3Completed1
DB00275Olmesartan3Completed1
DB06228Rivaroxaban3Recruiting1
DB00658Sevelamer3Completed1
DB00877Sirolimus3Completed1
DB01261Sitagliptin3Completed1
DB01261Sitagliptin3Terminated1
DB04876Vildagliptin3Completed2
DB00437Allopurinol4Completed1
DB00770Alprostadil4Unknown Status1
DB00098Antithymocyte immunoglobulin (rabbit)4Terminated1
DB01164Calcium Chloride4Recruiting1
DB00169Cholecalciferol4Active Not Recruiting1
DB01147Cloxacillin4Terminated1
DB00531Cyclophosphamide4Recruiting1
DB00080Daptomycin4Terminated1
DB08826Deferiprone4Completed1
DB09038Empagliflozin4Recruiting1
DB01225Enoxaparin4Completed1
DB01590Everolimus4Terminated1
DB00973Ezetimibe4Completed1
DB11728Fondaparinux4Terminated1
DB00569Fondaparinux sodium4Terminated1
DB00996Gabapentin4Terminated1
DB06703Gadobutrol4Completed1
DB00225Gadodiamide4Completed1
DB00789Gadopentetate dimeglumine4Completed1
DB09132Gadoteric acid4Completed1
DB00999Hydrochlorothiazide4Completed1
DB01050Ibuprofen4Completed1
DB00702Icodextrin4Recruiting1
DB00808Indapamide4Completed1
DB00047Insulin Glargine4Completed1
DB01309Insulin Glulisine4Completed1
DB01249Iodixanol4Terminated3
DB08947Iopamidol4Terminated1
DB09156Iopromide4Terminated1
DB09134Ioversol4Terminated2
DB00677Isoflurophate4Completed1
DB04398Lactic Acid4Recruiting1
DB01202Levetiracetam4Completed1
DB08882Linagliptin4Recruiting1
DB09407Magnesium chloride4Recruiting1
DB00688Mycophenolate mofetil4Terminated1
DB00607Nafcillin4Terminated1
DB00713Oxacillin4Terminated1
DB00497Oxycodone4Completed1
DB00073Rituximab4Terminated1
DB00641Simvastatin4Completed1
DB09153Sodium Chloride4Recruiting1
DB00864Tacrolimus4Terminated1
DB00512Vancomycin4Terminated1
DB00630Alendronic acidNot AvailableUnknown Status1
DB00612BisoprololNot AvailableRecruiting1
DB01373CalciumNot AvailableUnknown Status1
DB11093Calcium CitrateNot AvailableUnknown Status1
DB12362Diaminohydroxypropanetetraacetic acidNot AvailableNot Yet Recruiting1
DB00153ErgocalciferolNot AvailableUnknown Status1
DB09106Hydroxyethyl StarchNot AvailableCompleted1
DB01362IohexolNot AvailableCompleted1
DB00125L-ArginineNot AvailableRecruiting1
DB00601LinezolidNot AvailableCompleted1
DB09107Methoxy polyethylene glycol-epoetin betaNot AvailableCompleted1
DB00727NitroglycerinNot AvailableRecruiting1
DB01001SalbutamolNot AvailableRecruiting1
DB11094Vitamin DNot AvailableUnknown Status1
DB00399Zoledronic acidNot AvailableUnknown Status1