Cytochrome P450 3A7

Details

Name
Cytochrome P450 3A7
Synonyms
  • 1.14.14.1
  • CYPIIIA7
  • Cytochrome P450-HFLA
Gene Name
CYP3A7
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006949|Cytochrome P450 3A7
MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF
DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI
AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS
MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV
FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI
IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV
NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWREPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG
GLLLTEKPIVLKAESRDETVSGA
Number of residues
503
Molecular Weight
57525.03
Theoretical pI
9.59
GO Classification
Functions
aromatase activity / heme binding / iron ion binding / monooxygenase activity / oxygen binding
Processes
small molecule metabolic process / xenobiotic metabolic process
Components
endoplasmic reticulum membrane
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0019448|Cytochrome P450 3A7 (CYP3A7)
ATGGATCTCATCCCAAACTTGGCCGTGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGATA
CTCCTCTATCTATATGGAACCCGTACACATGGACTTTTTAAGAAGCTTGGAATTCCAGGG
CCCACACCTCTGCCTTTTTTGGGAAATGCTTTGTCCTTCCGTAAGGGCTATTGGACGTTT
GACATGGAATGTTATAAAAAGTATAGAAAAGTCTGGGGTATTTATGACTGTCAACAGCCT
ATGCTGGCTATCACAGATCCCGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCT
GTCTTCACAAACCGGAGGCCTTTCGGGCCAGTGGGATTTATGAAAAATGCCATCTCTATA
GCTGAGGATGAAGAATGGAAGAGAATACGATCATTGCTGTCTCCAACATTCACCAGCGGA
AAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTG
AGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAACACGTCTTTGGGGCCTACAGC
ATGGATGTGATCACTAGCACATCATTTGGAGTGAGCATCGACTCTCTCAACAATCCACAA
GACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTAATCCATTAGATCCATTCGTT
CTCTCAATAAAAGTCTTTCCATTCCTTACCCCAATTCTTGAAGCATTAAATATCACTGTG
TTTCCAAGAAAAGTTATAAGTTTTCTAACAAAATCTGTAAAACAGATAAAAGAAGGTCGC
CTCAAAGAGACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAAT
TCAAAAGACTCTGAGACCCACAAAGCTCTGTCTGATCTGGAGCTCATGGCCCAATCAATT
ATCTTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATATATGAA
CTGGCCACTCACCCTGATGTCCAGCAGAAAGTGCAGAAGGAAATTGATACAGTTTTACCC
AATAAGGCACCACCCACCTATGATACTGTGCTACAGTTGGAGTATCTTGACATGGTGGTG
AATGAAACACTCAGATTATTCCCAGTTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGAT
GTTGAAATCAATGGGATGTTTATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGTT
CTTCATCATGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGGTTCAGT
AAAAAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGA
AACTGCATTGGCATGAGGTTTGCTCTCGTGAACATGAAACTTGCTCTAGTCAGAGTCCTT
CAGAACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTACGCTTTGGA
GGACTTCTTCTAACAGAAAAACCCATTGTTCTAAAGGCTGAGTCAAGGGATGAGACCTTT
GTAGATATGGAGCCCATTCACATGGACTTTTTAAGAAGCTTGGCATTCCAGGGCCCACAC
CTCTGCTTTTTTTGGGAACTACTTTGTCCTACCATCAGATCCCGCTGA
Chromosome Location
7
Locus
7q21-q22.1
External Identifiers
ResourceLink
UniProtKB IDP24462
UniProtKB Entry NameCP3A7_HUMAN
GenBank Protein ID220149
GenBank Gene IDD00408
HGNC IDHGNC:2640
General References
  1. Komori M, Nishio K, Ohi H, Kitada M, Kamataki T: Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450. J Biochem. 1989 Feb;105(2):161-3. [PubMed:2722762]
  2. Finta C, Zaphiropoulos PG: The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. Gene. 2000 Dec 30;260(1-2):13-23. [PubMed:11137287]
  3. Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics. 2001 Mar;11(2):111-21. [PubMed:11266076]
  4. Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [PubMed:12690205]
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334]
  6. Wrighton SA, Vandenbranden M: Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family. Arch Biochem Biophys. 1989 Jan;268(1):144-51. [PubMed:2492179]
  7. Komori M, Nishio K, Fujitani T, Ohi H, Kitada M, Mima S, Itahashi K, Kamataki T: Isolation of a new human fetal liver cytochrome P450 cDNA clone: evidence for expression of a limited number of forms of cytochrome P450 in human fetal livers. Arch Biochem Biophys. 1989 Jul;272(1):219-25. [PubMed:2786707]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01211ClarithromycinapprovedunknownsubstrateDetails
DB00199Erythromycinapproved, investigational, vet_approvednosubstrateinhibitorDetails
DB00976TelithromycinapprovedunknownsubstrateinhibitorDetails
DB00908Quinidineapproved, investigationalunknownsubstrateDetails
DB00404Alprazolamapproved, illicit, investigationalunknownsubstrateDetails
DB00829Diazepamapproved, illicit, investigational, vet_approvedunknownsubstrateDetails
DB00897Triazolamapproved, investigationalunknownsubstrateDetails
DB00091Ciclosporinapproved, investigational, vet_approvedunknownsubstrateinducerDetails
DB00864Tacrolimusapproved, investigationalunknownsubstrateDetails
DB00224IndinavirapprovedunknownsubstrateinhibitorDetails
DB00220NelfinavirapprovedunknownsubstrateinhibitorDetails
DB01232Saquinavirapproved, investigationalunknownsubstrateinhibitorDetails
DB00604Cisaprideapproved, investigational, withdrawnunknownsubstrateDetails
DB00637Astemizoleapproved, withdrawnunknownsubstrateDetails
DB01114ChlorphenamineapprovedunknownsubstrateDetails
DB00342Terfenadineapproved, withdrawnunknownsubstrateDetails
DB00343Diltiazemapproved, investigationalunknownsubstrateinhibitorDetails
DB01023Felodipineapproved, investigationalunknownsubstrateDetails
DB00528Lercanidipineapproved, investigationalunknownsubstrateDetails
DB01115NifedipineapprovedunknownsubstrateDetails
DB00401NisoldipineapprovedunknownsubstrateDetails
DB01054Nitrendipineapproved, investigationalunknownsubstrateDetails
DB00661VerapamilapprovedunknownsubstrateinhibitorDetails
DB01076AtorvastatinapprovednosubstrateDetails
DB00439Cerivastatinapproved, withdrawnunknownsubstrateDetails
DB00227Lovastatinapproved, investigationalunknownsubstrateDetails
DB00641SimvastatinapprovedunknownsubstrateDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownsubstrateDetails
DB00741Hydrocortisoneapproved, vet_approvedunknownsubstrateDetails
DB00396Progesteroneapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00624Testosteroneapproved, investigationalunknownsubstrateDetails
DB00802Alfentanilapproved, illicitunknownsubstrateDetails
DB00673Aprepitantapproved, investigationalunknownsubstrateinhibitorDetails
DB01238Aripiprazoleapproved, investigationalunknownsubstrateDetails
DB00490Buspironeapproved, investigationalunknownsubstrateDetails
DB00201CaffeineapprovedunknownsubstrateDetails
DB01166Cilostazolapproved, investigationalunknownsubstrateDetails
DB00907Cocaineapproved, illicitunknownsubstrateDetails
DB00250Dapsoneapproved, investigationalunknownsubstrateDetails
DB01234Dexamethasoneapproved, investigational, vet_approvedunknownsubstrateinducerDetails
DB00514DextromethorphanapprovedunknownsubstrateDetails
DB01248Docetaxelapproved, investigationalunknownsubstrateDetails
DB01184Domperidoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB00700EplerenoneapprovedunknownsubstrateDetails
DB00813Fentanylapproved, illicit, investigational, vet_approvedunknownsubstrateDetails
DB01216FinasterideapprovedunknownsubstrateDetails
DB00619ImatinibapprovedunknownsubstrateinhibitorDetails
DB00502HaloperidolapprovedunknownsubstrateDetails
DB00762Irinotecanapproved, investigationalunknownsubstrateDetails
DB01227Levacetylmethadolapproved, investigationalunknownsubstrateDetails
DB00281Lidocaineapproved, vet_approvedunknownsubstrateDetails
DB00333Methadoneapproved, illicitunknownsubstrateDetails
DB00731Nateglinideapproved, investigationalunknownsubstrateDetails
DB00904OndansetronapprovedunknownsubstrateDetails
DB01100PimozideapprovedunknownsubstrateDetails
DB00571Propranololapproved, investigationalunknownsubstrateDetails
DB01224QuetiapineapprovedunknownsubstrateDetails
DB00468QuinineapprovedunknownsubstrateDetails
DB00734Risperidoneapproved, investigationalunknownsubstrateDetails
DB00938SalmeterolapprovedunknownsubstrateDetails
DB00203Sildenafilapproved, investigationalunknownsubstrateDetails
DB00877Sirolimusapproved, investigationalunknownsubstrateDetails
DB00398Sorafenibapproved, investigationalunknownsubstrateDetails
DB01268Sunitinibapproved, investigationalunknownsubstrateDetails
DB00675TamoxifenapprovedunknownsubstrateDetails
DB01229Paclitaxelapproved, vet_approvedunknownsubstrateDetails
DB06287TemsirolimusapprovedunknownsubstrateDetails
DB00656Trazodoneapproved, investigationalunknownsubstrateDetails
DB00541Vincristineapproved, investigationalunknownsubstrateDetails
DB00962Zaleplonapproved, illicit, investigationalunknownsubstrateDetails
DB01167Itraconazoleapproved, investigationalunknowninhibitorDetails
DB01026Ketoconazoleapproved, investigationalunknowninhibitorDetails
DB00501Cimetidineapproved, investigationalunknowninhibitorDetails
DB01118Amiodaroneapproved, investigationalunknowninhibitorDetails
DB00446Chloramphenicolapproved, vet_approvedunknowninhibitorDetails
DB00537Ciprofloxacinapproved, investigationalunknowninhibitorDetails
DB00705DelavirdineapprovedunknowninhibitorDetails
DB00176Fluvoxamineapproved, investigationalunknowninhibitorDetails
DB06730GestodeneinvestigationalunknowninhibitorDetails
DB01388Mibefradilinvestigational, withdrawnunknowninhibitorDetails
DB00834Mifepristoneapproved, investigationalunknowninhibitorDetails
DB01059NorfloxacinapprovedunknowninhibitorDetails
DB06731SeproxetineinvestigationalunknowninhibitorDetails
DB00582Voriconazoleapproved, investigationalunknowninhibitorDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvedunknownsubstrateDetails
DB00564Carbamazepineapproved, investigationalunknownsubstrateDetails
DB00257Clotrimazoleapproved, vet_approvedunknowninducerDetails
DB00458ImipramineapprovedunknownsubstrateDetails
DB00717NorethisteroneapprovedunknownsubstrateDetails
DB00780PhenelzineapprovedunknowninhibitorDetails
DB00252Phenytoinapproved, vet_approvedunknowninducerDetails
DB01058Praziquantelapproved, investigational, vet_approvedunknownsubstrateDetails
DB01045RifampicinapprovedunknowninducerDetails
DB00197Troglitazoneinvestigational, withdrawnunknowninhibitorDetails
DB00588Fluticasone propionateapprovedunknownsubstrateDetails
DB00755Tretinoinapproved, investigational, nutraceuticalunknownsubstrateDetails
DB04946IloperidoneapprovedunknownsubstrateDetails
DB01708Prasteroneapproved, investigational, nutraceuticalunknownsubstrateinhibitorDetails
DB05804Prasterone sulfateinvestigationalunknownsubstrateDetails
DB01174Phenobarbitalapproved, investigationalunknowninducerDetails
DB09102Daclatasvirapproved, investigationalunknownsubstrateDetails
DB09054IdelalisibapprovednosubstrateinhibitorDetails
DB09065CobicistatapprovedyessubstrateinhibitorDetails
DB06412Oxymetholoneapproved, illicitnoinhibitorDetails
DB00503Ritonavirapproved, investigationalnosubstrateinhibitorinducerDetails
DB06595Midostaurinapproved, investigationalunknowninducerDetails
DB11574ElbasvirapprovedunknownsubstrateinhibitorDetails
DB12483Copanlisibapproved, investigationalnosubstrateDetails
DB12332Rucaparibapproved, investigationalunknowninhibitorDetails
DB09061Cannabidiolapproved, investigationalunknownDetails
DB13943Testosterone cypionateapprovedunknownsubstrateDetails
DB13944Testosterone enanthateapprovedunknownsubstrateDetails
DB13946Testosterone undecanoateapproved, investigationalunknownsubstrateDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownsubstrateDetails
DB14011NabiximolsinvestigationalunknownDetails
DB14009Medical Cannabisexperimental, investigationalunknownDetails
DB00625Efavirenzapproved, investigationalunknowninducerDetails
DB13179TroleandomycinapprovedunknowninhibitorDetails
DB14185Aripiprazole lauroxilapproved, investigationalunknownsubstrateDetails
DB12070Letermovirapproved, investigationalnoinhibitorDetails
DB14538Hydrocortisone aceponateexperimental, vet_approvedunknownsubstrateDetails
DB14539Hydrocortisone acetateapproved, vet_approvedunknownsubstrateDetails
DB14540Hydrocortisone butyrateapproved, vet_approvedunknownsubstrateDetails
DB14541Hydrocortisone cypionateapproved, investigational, vet_approvedunknownsubstrateDetails
DB14542Hydrocortisone phosphateapproved, vet_approvedunknownsubstrateDetails
DB14543Hydrocortisone probutateapproved, vet_approvedunknownsubstrateDetails
DB14544Hydrocortisone valerateapproved, vet_approvedunknownsubstrateDetails
DB14545Hydrocortisone succinateapprovednosubstrateDetails
DB13867Fluticasoneapproved, experimentalunknownsubstrateDetails
DB08906Fluticasone furoateapprovedunknownsubstrateDetails
DB08930DolutegravirapprovedunknownsubstrateDetails
DB06595Midostaurinapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB13174RheinexperimentalunknowninhibitorDetails
DB11994Diacereinapproved, investigationalunknowninhibitorDetails
DB11605MyrrhapprovedunknowninducerDetails
DB11691Naldemedineapproved, investigationalnosubstrateDetails
DB13878Pibrentasvirapproved, investigationalunknowninhibitorDetails
DB13879Glecaprevirapproved, investigationalunknownsubstrateinhibitorDetails
DB11586Asunaprevirapproved, investigational, withdrawnnosubstrateDetails
DB09568Omega-3-carboxylic acidsapproved, investigationalnosubstrateDetails
DB01601LopinavirapprovednoinhibitorDetails
DB01149Nefazodoneapproved, withdrawnnoinhibitorDetails
DB11431Moxidectininvestigational, vet_approvednosubstrateDetails
DB13141Ambroxol acefyllinateexperimental, investigationalnosubstrateDetails
DB11792MirodenafilinvestigationalunknownsubstrateDetails
DB11979Elagolixapproved, investigationalyessubstrateDetails
DB08865CrizotinibapprovedunknowninhibitorDetails
DB11703Acalabrutinibapproved, investigationalunknownsubstrateDetails
DB12267Brigatinibapproved, investigationalunknowninducerDetails
DB12307ForetinibinvestigationalunknownsubstrateDetails
DB09205Moxisylyteapproved, investigationalnosubstrateDetails
DB12130Lorlatinibapproved, investigationalunknownsubstrateinhibitorinducerDetails