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Identification
NameSodium bicarbonate
Accession NumberDB01390
TypeSmall Molecule
GroupsApproved
DescriptionSodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Structure
Thumb
Synonyms
Baking soda
Bicarbonate of soda
Carbonic acid monosodium salt
e 500
e-500
e500
NaHCO3
Natriumhydrogenkarbonat
Sodium acid carbonate
Sodium bicarbonate
Sodium hydrogen carbonate
Sodium hydrogencarbonate
External IDs Not Available
Product Ingredients Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
800 Sodium Bicarbonate PowderPowder, for solution650 gHemodialysisBaxter Laboratories1988-12-31Not applicableCanada
BibagPowder, for solution650 gHemodialysisFresenius Medical Care Deutchland Gmbh2009-12-10Not applicableCanada
Bicarb Hemodial Conc 81.25gm/lLiquid81.25 gHemodialysisBicarbolyte Corporation1986-12-311998-06-08Canada
Bicarbolyte Bicar Hemodialysis ConcLiquid72 gHemodialysisBicarbolyte Corporation1986-12-311998-06-08Canada
Bicarbonate Conc Mb-330 Pwr 650mg/pckPowder650 gHemodialysisRenal Systems, Division Of Minntech Corp.1985-12-311998-11-02Canada
Bicarbonate Concentrate 4105Liquid80.68 gHemodialysisBaxter Laboratories1988-12-312002-08-01Canada
Bicarbonate Concentrate B38Solution80.7 gHemodialysisChief Medical Supplies Ltd2005-07-04Not applicableCanada
Bicarbonate Concentrate D17000Solution81.3 gHemodialysisBaxter Laboratories1986-12-31Not applicableCanada
BicartPowder650 gHemodialysisBaxter Laboratories1990-12-31Not applicableCanada
BicartPowder720 gHemodialysisBaxter Laboratories2013-09-26Not applicableCanada
BicartPowder1250 gHemodialysisBaxter Laboratories2013-10-22Not applicableCanada
Biflexy 1100Powder, for solution1100 gHemodialysisBellco SrlNot applicableNot applicableCanada
Biflexy 750Powder, for solution750 gHemodialysisBellco SrlNot applicableNot applicableCanada
Biflexy 900Powder, for solution900 gHemodialysisBellco Srl2016-08-08Not applicableCanada
D12057Powder, for solution650 gHemodialysisBio Pharm, Inc.1988-12-311996-09-09Canada
Hema Bp-38Powder6 kgHemodialysisChief Medical Supplies Ltd2006-07-03Not applicableCanada
HemacartPowder, for solution650 gHemodialysisChief Medical Supplies Ltd2009-12-21Not applicableCanada
Naturalyte Dry Pack for Bicarbonate DialysisPowder650 gHemodialysisFresenius Medical Care North America1998-04-142016-07-26Canada
Naturalyte Sodium Bicarbonate Liquid ConcentrateLiquid81.25 gHemodialysisFresenius Medical Care Korea1997-04-142017-01-10Canada
Sodium BicarbonateInjection, solution84 mg/mLIntravenousMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2010-05-03Not applicableUs
Sodium Bicarbonate 5% Inj 50mg/ml USPLiquid50 mgIntravenousMcgaw Inc.1993-12-311997-08-15Canada
Sodium Bicarbonate 5% Inj 5gm/100ml USPSolution5 gIntravenousBaxter Laboratories1991-12-312011-05-10Canada
Sodium Bicarbonate Dry Concentrate Ro9504Powder, for solution672 gHemodialysisGenpharm Ulc1990-12-312003-07-23Canada
Sodium Bicarbonate Dry Concentrate Rx002cPowder650 gHemodialysisGenpharm Ulc1996-10-102004-07-30Canada
Sodium Bicarbonate Inj 4.2%Liquid42 mgIntravenousInternational Medication Systems, Limited1971-12-311997-08-15Canada
Sodium Bicarbonate Inj 4.2% Infant USPSolution42 mgIntravenousHospira, Inc.1987-12-31Not applicableCanada
Sodium Bicarbonate Inj 7.5%Solution75 mgIntravenousHospira, Inc.1979-12-31Not applicableCanada
Sodium Bicarbonate Inj 7.5%Liquid75 mgIntravenousInternational Medication Systems, Limited1971-12-311997-08-15Canada
Sodium Bicarbonate Inj 8.4%Solution84 mgIntravenousHospira, Inc.1974-12-31Not applicableCanada
Sodium Bicarbonate Inj 8.4%Liquid84 mgIntravenousInternational Medication Systems, Limited1971-12-311997-08-15Canada
Sodium Bicarbonate Injection 75mg/mlSolution75 mgIntravenousAstra Zeneca1986-12-312004-10-14Canada
Sodium Bicarbonate Injection 84mg/mlLiquid84 mgIntravenousAstra Zeneca1986-12-312004-02-27Canada
Sodium Bicarbonate USP for Hemodialysis D12276Powder650 gHemodialysisBaxter Laboratories1996-09-10Not applicableCanada
Sol-cart BPowder, for solution650 gHemodialysisB. Braun Avitum AgNot applicableNot applicableCanada
Sol-cart BPowder, for solution760 gHemodialysisB. Braun Avitum AgNot applicableNot applicableCanada
Sol-cart BPowder, for solution1100 gHemodialysisB. Braun Avitum AgNot applicableNot applicableCanada
Vivia BicarbPowder, for solution750 gHemodialysisBaxter LaboratoriesNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sodium BicarbonateInjection, solution42 mg/mLIntravenousHospira, Inc.2017-01-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousGeneral Injectables & Vaccines2010-08-01Not applicableUs
Sodium BicarbonateInjection, solution42 mg/mLIntravenousHospira, Inc.1984-01-27Not applicableUs
Sodium BicarbonateInjection, solution75 mg/mLIntravenousHospira, Inc.2006-05-18Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousHospira, Inc.2006-05-18Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
After Bite KidsLiquid5 g/100gTopicalTender Corporation2014-11-26Not applicableUs
After Bite SensitiveLiquid5 g/100gTopicalTender Corporation2014-11-26Not applicableUs
After Bite The Itch EraserLiquid50 mg/mLTopicalTender Corporation2014-09-02Not applicableUs
After Bite The Itch Eraser KidsLiquid5 g/100gTopicalTender Corporation2014-11-262016-10-29Us
Anti-empachoLiquid525 mg/15mLOralMenper Distributors2012-02-21Not applicableUs
Arm and Hammer Baking SodaPowder, for solution1 g/gOralChurch & Dwight Company, Inc.2000-01-01Not applicableUs
Assured Bug Bite ReliefLiquid5 g/100gTopicalShanghai Weierya Daily Chemicals Factory2015-11-10Not applicableUs
Baking Soda USPPowder100 %OralRegal Pharms, Division Of Bradcan Corporation1987-12-311996-12-16Canada
Brioschi Effervescent AntacidGranule, effervescent1.02 g/5gOralNeobourne Pharma Lp2015-06-302016-02-06Us
Brioschi Effervescent Antacid - 1.8gm/6gmGranule, effervescent1.8 gOralBrioschi, Inc.1998-05-142003-02-14Canada
Brioschi Effervescent Antacid Pwr 280.3mg/gmGranule, effervescent269 mgOralBrioschi, Inc.1910-12-312003-02-14Canada
De LA Cruz DesempachoLiquid525 mg/15mLOralDLC Laboratories, Inc.2012-08-06Not applicableUs
De LA Cruz Sodium Bicarbonate AntacidPowder2.6 g/2.6gOralDLC Laboratories, Inc.2013-09-25Not applicableUs
Ecodent Ultimate Essential Mouthcare Sparkling Clean MintLiquid25 mg/mLOralLotus Brands, Inc.2013-06-01Not applicableUs
Ecodent Ultimate Essential Mouthcare Spicy-cool CinnamonLiquid25 mg/mLOralLotus Brands, Inc.2013-06-01Not applicableUs
Goongsecret Calming Bath Oriental Formula for BabiesPowder165 g/300gTopical0to7 Inc2013-07-01Not applicableUs
Humco Sodium BicarbonatePowder1000 mg/gOralHumco Holding Group. Inc.1998-03-25Not applicableUs
Skin ProtectantLiquid5 g/100gTopicalShanghai Kejing Cleaning Products Co., Ltd.2016-01-18Not applicableUs
Sodium BicarbonatePowder100 %Oral; TopicalLab Valmo EnregistrÉ, Division Of Technilab Inc.1981-12-311999-09-17Canada
Sodium BicarbonateTablet325 mg/1OralRugby2010-04-21Not applicableUs
Sodium BicarbonateTablet650 mg/1OralRugby2010-03-08Not applicableUs
Sodium BicarbonateTablet650 mg/1OralMirror Pharmaceuticals LLC2011-01-24Not applicableUs
Sodium BicarbonateTablet, orally disintegrating650 mg/1OralAvera Mc Kennan Hospital2015-03-05Not applicableUs
Sodium BicarbonateTablet, orally disintegrating650 mg/1OralAphena Pharma Solutions Tennessee, Inc.2012-06-26Not applicableUs
Sodium BicarbonateTablet, orally disintegrating650 mg/1OralA S Medication Solutions2012-06-26Not applicableUs
Sodium BicarbonateTablet, orally disintegrating650 mg/1OralRising Pharmaceuticals2012-06-26Not applicableUs
Sodium Bicarbonate 10 GrTablet648 mg/1OralReliable 1 Laboratories2015-11-01Not applicableUs
Sodium Bicarbonate 5 GrTablet324 mg/1OralReliable 1 Laboratories2015-11-01Not applicableUs
Sodium Bicarbonate AntacidPowder1 g/gOralCompania Farmaceutica, s.a. De c.v.2017-02-16Not applicableUs
Sodium Bicarbonate AntacidPowder2.6 g/2.6gOralDannso corp./d.b.a. Essential Products2013-09-25Not applicableUs
Sodium Bicarbonate AntacidTablet325 mg/1OralRugby2015-03-25Not applicableUs
Sodium Bicarbonate AntacidTablet650 mg/1OralCardinal Health2010-03-08Not applicableUs
Sodium Bicarbonate AntacidTablet650 mg/1OralRugby2015-03-25Not applicableUs
Sodium Bicarbonate Tab 300mgTablet300 mgOralD.C. Labs Limited1951-12-312003-07-11Canada
Sodium Bicarbonate Tab 600mgTablet600 mgOralD.C. Labs Limited1951-12-312003-07-11Canada
The Itch Eraser SensitiveCream50 mg/gTopicalTender Corporation2015-11-17Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Assured Bug Bite ReliefLiquid5 g/100gTopicalShanghai Weierya Daily Chemicals Factory2015-11-10Not applicableUs
NeutInjection.2 g/5mLIntravenousGeneral Injectables & Vaccines2014-07-31Not applicableUs
Neut Sodium BicarbonateInjection, solution.2 g/5mLIntravenousCardinal Health2005-08-22Not applicableUs
Neut Sodium BicarbonateInjection, solution.2 g/5mLIntravenousHospira, Inc.2005-08-22Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousFresenius Kabi2000-08-10Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousHospira, Inc.1985-04-18Not applicableUs
Sodium BicarbonateInjection, solution1 meq/mLIntravenousGeneral Injectables & Vaccines2010-08-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousCardinal Health1985-05-01Not applicableUs
Sodium BicarbonateSolution42 mg/mLIntravenousAPP Pharmaceuticals, Inc.2000-08-10Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousHospira, Inc.1984-04-13Not applicableUs
Sodium BicarbonateInjection.9 meq/mLIntravenousGeneral Injectables & Vaccines2011-03-10Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousCardinal Health1985-04-18Not applicableUs
Sodium BicarbonateTablet650 mg/1OralCardinal Health2011-06-06Not applicableUs
Sodium BicarbonateInjection84 mg/mLParenteralAmphastar Pharmaceuticals, Inc.2000-06-012016-12-06Us
Sodium BicarbonateInjection, solution84 mg/mLIntravenousCardinal Health1985-04-18Not applicableUs
Sodium BicarbonateInjection84 mg/mLIntravenousInternational Medication Systems, Limited2000-06-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousHospira, Inc.1985-05-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousA S Medication Solutions1985-04-18Not applicableUs
Sodium BicarbonateSolution84 mg/mLParenteralOnpharma, Inc.2010-07-22Not applicableUs
Sodium BicarbonateInjection, solution42 mg/mLIntravenousGeneral Injectables & Vaccines2010-03-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousMesource Pharmaceuticals2014-07-03Not applicableUs
Sodium BicarbonateInjection, solution75 mg/mLIntravenousHospira, Inc.1985-02-14Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousGeneral Injectables & Vaccines2010-08-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousCardinal Health1985-04-18Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousRemedy Repack2015-03-072016-03-29Us
Sodium BicarbonateInjection, solution44.6 meq/50mLIntravenousGeneral Injectables & Vaccines2010-08-012017-02-02Us
Sodium BicarbonateInjection, solution42 mg/mLIntravenousCardinal Health1984-01-27Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Accusol 35 K0Chief Medical Supplies Ltd
Accusol 35 K2Chief Medical Supplies Ltd
Accusol 35 K4Chief Medical Supplies Ltd
Alka SeltzerSalimex, S.A.
Alka Seltzer EvtMiles Inc. Pharmaceutical Division
Alka Seltzer FlavouredMiles Inc. Pharmaceutical Division
Alka Seltzer OriginalNavajo Manuracturing Company
Alka-seltzerLil' Drug Store Products, Inc.
Alka-seltzer Extra StrengthBayer Health Care Llc.
Alka-seltzer FlavouredBayer Inc Consumer Care
Alka-seltzer Flavoured - EvtBayer Inc Consumer Care
Alka-seltzer GoldBayer Health Care Llc.
Alka-seltzer HeartburnBayer Health Care Llc, Consumer Care
Alka-seltzer Lemon LimeBayer Health Care Llc.
Alka-seltzer OriginalR J General Corporation
Alka-seltzer Xtra StrengthBayer Health Care Llc, Consumer Care
Baros Effervescent GranulesTyco Healthcare
Bc-I Concentrate PwrRenal Systems, Division Of Minntech Corp.
Bi-peglytePendopharm Division Of De Pharmascience Inc
Bicarbolyte Bicar Hemodialysis ConcBicarbolyte Corporation
Bicarbolyte Bicar Hemodiaylsis ConcBicarbolyte Corporation
Bicarbonate Chloride D12052Baxter Laboratories
Bicarbonate Concentrate D16000Baxter Laboratories
Bicarbonate Concentrate D16001Baxter Laboratories
Bicarbonate Concentrate D20000Baxter Laboratories
Bicarbonate Concentrate No 4202 LiqWestern Dialysis Supplies Ltd.
Bicart Select Combi-pakBaxter Laboratories
BicaruvasProsana Distribuciones, S.A. De C.V.
Brioschi Childrens Effervescent AntacidBrioschi, Inc.
Brioschi Effervescent AntacidBrioschi, Inc.
Bromo SeltzerTower Laboratories Ltd
Bss PlusAlcon, Inc.
Carbicarb InjectionInternational Medication Systems, Limited
Ceo-twoBeutlich L.P.
Ceo-two Bowel Evacuant SuppositoriesBeutlich L.P.
Citrocarbonate Eff PwsRoberts Pharmaceutical
ColytePendopharm Division Of De Pharmascience Inc
Colyte With Flavor PacksAlaven Pharmaceutical
CvsCvs Health
Cvs Health Antacid and Pain RelieverCvs Health
E-Z-gas 2 GranulesTherapex Division De E Z Em Canada Inc
Effervescent Antacid and Pain ReliefCardinal Health
Effervescent Pain ReliefWestern Family Foods
Effervescent Pain Relief Fast ReliefDeseret Laboratories, Inc.
Effervescent Pain Relief Fast Relief Fast ReliefMajor
Electropeg SolutionTechnilab Pharma Inc.
EstomarolLaboratorios Imperiales, S.A. De C.V.
Gavilyte - C TmGavis Pharmaceuticals, LLC.
Gavilyte - NGavis Pharmaceuticals, LLC.
Gavilyte G TmLupin Pharmaceuticals
Gingera Effervescent AntacidBrioschi, Inc.
GolytelyBraintree Laboratories
Golytely Gi Lavage SolutionBraintree Laboratories
InonSato Pharmaceutical
Jamp-electropegJamp Pharma Corporation
Jamp-electropeg With Flavour PacketJamp Pharma Corporation
JamplyteJamp Pharma Corporation
Jamplyte 280Jamp Pharma Corporation
Kettle Neti PotCardinal Health 414, Llc
Klean-prepPendopharm Division Of De Pharmascience Inc
LyteprepTherapex Division De E Z Em Canada Inc
Medique Medi SeltzerUnifirst First Aid
Neutra-seltzerTeva
Normo GastrylSabex Inc
Normocarb 25Dialysis Solutions Inc.
Normocarb 35Dialysis Solutions Inc.
NulytelyPhysicians Total Care, Inc.
Ocl SolutionAbbott
Ohta's Isan Stomach PowderMaizun Calber (Canada) Ltd.
Ohtas Isan AntacidOhta's Isan Co., Ltd
Omeprazole and Sodium BicarbonateOceanside Pharmaceuticals
Omeprazole and Sodium BicrabonateDr Reddy's Laboratories
Omeprazole Sodium BicarbonateCipla Limited
Omeprazole/sodium BicarbonatePrasco, Laboratories
Ora Rinse LiqThompson Mckay Pharms Ltd.
Pain Relief Fast ReliefSelect Brand
Peg-3350 and ElectrolytesAffordable Pharmaceuticals, LLC
Peg-3350, Sodium Chloride, Sodium Bicarbonate and Potassium ChlorideAffordable Pharmaceuticals, LLC
Peglyte PowderPendopharm Division Of De Pharmascience Inc
Peglyte SolutionPharmascience Inc
Phoxillum Bk4/2.5Baxter Laboratories
Picot Plus EffervescentBristol Myers Squibb De Mexico, S. De R.L. De C. V.
Pleo Alkala AntacidSanum Kehlbeck Gmbh & Co Kg
Polyethylene Glycol 3350 and ElectrolytesMylan Pharmaceuticals
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride - UnflavoredStrides Shasun Limited
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride With Lemon FlavorStrides Shasun Limited
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride With Orange FlavorStrides Shasun Limited
Polyethylene Glycol-3350 and ElectrolytesNovel Laboratories, Inc.
Polyethylene Glycol-3350 and Electrolytes With Flavor PackNovel Laboratories, Inc.
Polyethylene Glycol-3350, Sodium Chloride, Potassium Chloride and Sodium BicarbonateNovel Laboratories, Inc.
Premier Value Antacid and Pain Relief MedicineChain Drug Consortium
Prism0calBaxter Laboratories
Prism0cal B22k0/0Baxter Laboratories
Prismasol 0Baxter Laboratories
Prismasol 2Baxter Laboratories
Prismasol 4Baxter Laboratories
Prolax - PwsRivex Pharma Inc.
R04940 LiqBdh Inc.
Relief Otc AntacidTummy Company, Inc.
Riga Purgative Lemon Flav LiqGlendale Agencies
Sal De Uvas PicotReckitt Benckiser Mexico, s.a. De c.v.
Saline RefillsCardinal Health 414, Llc
Saline WashTarget Corporation.
SinucleanseAscent Consumer Products, Inc.
Sinucleanse Micro-filtered Nasal Wash SystemAscent Consumer Products, Inc.
Sinucleanse Neti-potAscent Consumer Products, Inc.
Sinucleanse SqueezeAscent Consumer Products, Inc.
Sinus WashCvs Health
Soda Mint TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Sodium Bicarbonate-chloride Dry ConcentrateGenpharm Ulc
Sodium Bicarbonate-chloride Dry Concentrate R04955Genpharm Ulc
Sodium Bicarbonate-chloride Liquid Concentrate Ro4941Genpharm Ulc
Solution CardaLaboratoire Atlas Inc
Stomachin AntacidChang Kuo Chou Pharmaceutical Co. Ltd.
Thunas BilexThuna Herbal Remedies Ltd.
Top Value Effervescent Pain ReliefTower Laboratories Ltd
Topcare Omeprazole and Sodium BicarbonateTopco Associates
Trilyte With Flavor PacksWallace Pharmaceuticals Inc.
Unik Zoru PwrTherapex Division De E Z Em Canada Inc
Unik Zoru TabTherapex Division De E Z Em Canada Inc
Urasal GranulesAxxess Pharma Inc.
Vida Mia Pain ReliefNavarro Discount Pharmacies, LLC
Walgreens Filtered Squeeze Sinus Wash SystemWalgreen
Walgreens Sinus Wash Squeeze Bottle KitWalgreen
Well At WalgreensWalgreen
Winco Foods Effervescent Antacid and Pain ReliefWin Co Foods, Llc,
Woodward's Gripe Water LiqW Woodwards C/O Lrc International
Yeti Pot- Schnoz WashHealthland Llc
Zee-seltzer Antacid and Pain RelieverZee Medical Inc
ZegeridPhysicians Total Care, Inc.
Zegerid OtcBayer
Categories
UNII8MDF5V39QO
CAS number144-55-8
WeightAverage: 84.0066
Monoisotopic: 83.982338573
Chemical FormulaCHNaO3
InChI KeyUIIMBOGNXHQVGW-UHFFFAOYSA-M
InChI
InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
IUPAC Name
sodium hydrogen carbonate
SMILES
[Na+].OC([O-])=O
Pharmacology
IndicationSodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
Structured Indications
PharmacodynamicsIntravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.
Mechanism of actionSodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]
TargetKindPharmacological actionActionsOrganismUniProt ID
Hydrogen ionsSmall moleculeyes
neutralizer
not applicabledetails
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium bicarbonate.Approved, Vet Approved
FlecainideSodium bicarbonate may decrease the arrhythmogenic activities of Flecainide.Approved, Withdrawn
LithiumSodium bicarbonate may increase the excretion rate of Lithium which could result in a lower serum level and potentially a reduction in efficacy.Approved
Food InteractionsNot Available
References
Synthesis Reference

Alan B. Gancy, Rustom P. Poncha, “Production of low bulk density product from sodium bicarbonate by the use of an inert gas stream.” U.S. Patent US3984527, issued August, 1922.

US3984527
General ReferencesNot Available
External Links
ATC CodesB05XA02B05CB04
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceTransplantation, Kidney1
0CompletedTreatmentPulmonary Ventilation1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedTreatmentAcid Reflux / Gastro Oesophageal Reflux Disease1
1CompletedTreatmentGastric Emptying / Healthy Volunteers1
1CompletedTreatmentHeartburn1
1CompletedTreatmentNeoplasms, Malignant1
1CompletedTreatmentPancreatic Cancers1
1RecruitingOtherHealthy Volunteers1
1RecruitingPreventionChronic Kidney Disease (CKD)1
1RecruitingTreatmentChronic Kidney Disease (CKD) / Metabolic Acidosis / Sickle Cell Anemia1
1TerminatedSupportive CareCancers / Lymphoma NOS / Malignancies, Hematologic / Malignant Solid Tumors / Multiple Myeloma (MM) / Neoplasms Metastasis / Pain / Tumors / Unresectable Malignant Neoplasm1
1Unknown StatusDiagnosticAdjunct to general anesthesia therapy1
1, 2Unknown StatusTreatmentPneumonia1
2CompletedPreventionCardiac Surgery and Cardiopulmonary Bypass1
2CompletedPreventionContrast Induced Nephropathy (CIN)2
2CompletedPreventionKidney Injury1
2CompletedPreventionRadiographic Contrast Agent Nephropathy1
2CompletedTreatmentCardiac Arrest / Metabolic Acidosis1
2CompletedTreatmentOliguria / Renal Impairments / Systemic Inflammatory Response Syndrome (SIRS)1
2RecruitingNot AvailableBowel Cleansing1
2RecruitingTreatmentAcute Kidney Injury (AKI) / Congenital Heart Disease (CHD)1
2RecruitingTreatmentChronic Kidney Disease (CKD)1
2TerminatedTreatmentAcute Kidney Injury (AKI)1
2, 3CompletedPreventionContrast Induced Nephropathy (CIN)1
2, 3CompletedTreatmentChronic Kidney Disease (CKD)1
2, 3RecruitingTreatmentChronic Kidney Disease (CKD) / Metabolic Acidosis1
2, 3TerminatedPreventionCardiopulmonary Bypass / Surgery, Cardiac1
2, 3Unknown StatusDiagnosticDetection of the Correct Position of Intravenous Line1
2, 3Unknown StatusDiagnosticExtravasation / Infiltration1
3CompletedNot AvailableBowel Preparation for Colonoscopy1
3CompletedNot AvailableColonoscopy1
3CompletedNot AvailableContrast Induced Nephropathy (CIN) / Kidney Diseases1
3CompletedNot AvailableGastric Acid / Human Experimentation2
3CompletedNot AvailableIntragastric Acidity1
3CompletedNot AvailableLocal Anesthesia2
3CompletedDiagnosticBowel Preparation for Colonoscopy1
3CompletedDiagnosticBowel Preparation, Efficacy, Tolerability, Safety1
3CompletedPreventionChronic Kidney Disease (CKD)1
3CompletedPreventionRenal Failure1
3CompletedSupportive CareColon Adenomas / Colorectal Cancers1
3CompletedTreatmentCataracts2
3CompletedTreatmentColon Cancer1
3CompletedTreatmentColonoscopy1
3CompletedTreatmentHuman Experimentation1
3CompletedTreatmentOccasional Constipation1
3CompletedTreatmentReflux, Gastroesophageal1
3Not Yet RecruitingOtherDigestive System Diseases1
3RecruitingPreventionAcute Kidney Injury (AKI) / Contrast media reaction1
3RecruitingTreatmentMetabolic Acidosis1
3RecruitingTreatmentMyocardial Injury After Noncardiac Surgery (MINS)1
3TerminatedPreventionContrast Induced Kidney Injury1
3TerminatedPreventionHypopharynx Cancer / Oropharynx Cancers1
3Unknown StatusDiagnosticColonoscopy1
3Unknown StatusPreventionAcute Kidney Failure1
3Unknown StatusPreventionChronic Kidney Disease (CKD)1
3Unknown StatusPreventionKidney Failures, Acute1
4CompletedNot AvailableColonoscopy1
4CompletedNot AvailableNormal Healthy Subject Population1
4CompletedPreventionContrast Induced Acute Kidney Injury1
4CompletedPreventionContrast Induced Nephropathy (CIN)2
4CompletedPreventionContrast media reaction / Kidney Diseases1
4CompletedPreventionContrast-Induced Nephropathy1
4CompletedPreventionEmergent Coronary Procedure1
4CompletedPreventionMarginal Ulcers1
4CompletedPreventionProphylaxis of Pulmonary embolism / Radiographic Contrast Agent Nephropathy1
4CompletedSupportive CareEnd-Stage Renal Disease (ESRD)1
4CompletedSupportive CarePain1
4CompletedTreatmentColon Cancer1
4CompletedTreatmentColonoscopy2
4CompletedTreatmentContrast Induced Nephropathy (CIN)1
4CompletedTreatmentErosive Esophagitis(EE)1
4CompletedTreatmentHeartburn1
4CompletedTreatmentPreparation for Colonoscopy1
4Enrolling by InvitationPreventionOral Mucositis1
4Enrolling by InvitationTreatmentLocal Anesthesia1
4Not Yet RecruitingTreatmentDiabetic Kidney Disease / Diabetic Nephropathies / Type 1 Diabetes Mellitus (T1DM)1
4RecruitingDiagnosticChronic Kidney Disease (CKD) / Prophylaxis of Pulmonary embolism / Pulmonary Cancer / Renal Artery Stenosis1
4RecruitingPreventionAcute Kidney Injury (AKI)1
4RecruitingPreventionAcute Kidney Injury (AKI) / Aortic Valve Disease / Chronic Kidney Disease (CKD) / Contrast Induced Nephropathy (CIN)1
4RecruitingTreatmentSubjets Requiring a Colonoscopy1
4RecruitingTreatmentVeins, Varicose1
4TerminatedPreventionContrast Media / Kidney Failures, Acute1
4Unknown StatusHealth Services ResearchColonoscopy1
4Unknown StatusTreatmentContrast Induced Nephropathy (CIN)1
4Unknown StatusTreatmentSudden Cardiac Arrest1
Not AvailableActive Not RecruitingDiagnosticDiabetes Mellitus (DM)1
Not AvailableCompletedNot AvailableEffectiveness of SMS to Fix PC Interval1
Not AvailableCompletedNot AvailableSpinal Cord Injuries (SCI)1
Not AvailableCompletedNot AvailableThe Timing of Bowel Preparation in Outpatient Colonoscopy1
Not AvailableCompletedPreventionAcute Renal Failure Contrast Nephropathy1
Not AvailableCompletedPreventionContrast Induced Nephropathy (CIN)1
Not AvailableCompletedPreventionDysglycaemia / Insulin Resistance / Type 2 Diabetes Mellitus (T2D)1
Not AvailableCompletedTreatmentCardiac Arrest1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / Metabolic Acidosis1
Not AvailableCompletedTreatmentHepatic Encephalopathy / Liver Cirrhosis / Portosystemic Encephalopathy / PSE1
Not AvailableCompletedTreatmentOral Hygiene1
Not AvailableNot Yet RecruitingTreatmentChronic Kidney Disease (CKD) / Metabolic Acidosis1
Not AvailableRecruitingDiagnosticColonoscopy1
Not AvailableRecruitingHealth Services ResearchAcute Kidney Injury (AKI)1
Not AvailableRecruitingScreeningColonoscopy1
Not AvailableRecruitingTreatmentChronic Renal Insufficiency / Diabetes Mellitus (DM)1
Not AvailableRecruitingTreatmentHealthy Volunteers1
Not AvailableTerminatedPreventionContrast Induced Nephropathy (CIN)1
Not AvailableTerminatedSupportive CareNeoplasm Related Pain (Acute) (Chronic)1
Not AvailableUnknown StatusDiagnosticBowel Preparation for Colonoscopy1
Not AvailableUnknown StatusDiagnosticPreserving Kidney Function in People Who Are at High Risk of Developing Contrast-induced Nephropathy1
Not AvailableUnknown StatusPreventionAcute Kidney Injury (AKI)1
Not AvailableUnknown StatusTreatmentEsophagus, Barrett / Reflux, Gastroesophageal1
Not AvailableWithdrawnScreeningPatients Undergoing Screening or Surveillance Colonoscopy1
Not AvailableWithdrawnTreatmentAltered Mental Status / AMS / HE / Hepatic Encephalopathy / Liver Cirrhosis1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
LiquidTopical50 mg/mL
LiquidTopical5 g/100g
LiquidOral525 mg/15mL
Powder, for solutionOral1 g/g
PowderOral100 %
Powder, for solutionHemodialysis
Kit; powder, for solution; tablet, delayed releaseOral
LiquidHemodialysis81.25 g
LiquidHemodialysis72 g
LiquidHemodialysis80.68 g
SolutionHemodialysis80.7 g
SolutionHemodialysis
SolutionHemodialysis81.3 g
LiquidHemodialysis
PowderHemodialysis1250 g
PowderHemodialysis650 g
PowderHemodialysis720 g
Kit; powder, for solutionHemodialysis
Powder, for solutionHemodialysis750 g
Powder, for solutionHemodialysis900 g
Granule, effervescentOral
Granule, effervescentOral1.02 g/5g
Granule, effervescentOral1.8 g
Granule, effervescentOral269 mg
LiquidIntravenous
SuppositoryRectal
Powder, for solutionNasogastric
Kit
PowderNasal
SolutionNasal
PowderOral2.6 g/2.6g
LiquidOral25 mg/mL
Tablet, effervescentOral
PowderTopical165 g/300g
PowderHemodialysis6 kg
Powder, for solutionHemodialysis650 g
PowderOral1000 mg/g
GranuleOral
InjectionIntravenous.2 g/5mL
Injection, solutionIntravenous.2 g/5mL
SolutionOral
Capsule, gelatin coatedOral
Powder, for suspensionOral
Liquid; mouthwashOral
SolutionIntravenous
SolutionHemodialysis; Intravenous
LiquidOral
TabletOral
InjectionIntravenous.9 meq/mL
InjectionIntravenous84 mg/mL
InjectionParenteral84 mg/mL
Injection, solutionIntravenous1 meq/mL
Injection, solutionIntravenous42 mg/mL
Injection, solutionIntravenous44.6 meq/50mL
Injection, solutionIntravenous75 mg/mL
Injection, solutionIntravenous84 mg/mL
PowderOral; Topical100 %
SolutionIntravenous42 mg/mL
SolutionParenteral84 mg/mL
Tablet, orally disintegratingOral650 mg/1
TabletOral648 mg/1
TabletOral324 mg/1
LiquidIntravenous50 mg
SolutionIntravenous5 g
PowderOral1 g/g
TabletOral325 mg/1
TabletOral650 mg/1
Powder, for solutionHemodialysis672 g
LiquidIntravenous42 mg
SolutionIntravenous42 mg
LiquidIntravenous75 mg
SolutionIntravenous75 mg
LiquidIntravenous84 mg
SolutionIntravenous84 mg
TabletOral300 mg
TabletOral600 mg
PowderHemodialysis
Powder, for solutionHemodialysis1100 g
Powder, for solutionHemodialysis760 g
CapsuleOral
PowderOral
CreamTopical50 mg/g
Powder, for solutionNasogastric; Oral
KitNasal
Powder, for solutionNasal
Powder, for solutionOral
Granule, for solutionNasal
Prices
Unit descriptionCostUnit
Golytely 236 gm Solution28.0USD bottle
Colyte 240 gm Solution26.0USD bottle
Golytely 227.1 gm Solution Packet21.85USD packet
Colyte-Flavored 240 gm Solution18.17USD bottle
Elliotts b solution ampule4.71USD ml
Sodium bicarb 4.2% vial1.45USD ml
Neut 4% vial0.92USD ml
Bss plus eye solution0.2USD ml
Sodium bicarb 650 mg tablet0.07USD tablet
Antacid 650 mg tablet0.05USD tablet
Antacid 325 mg tablet0.04USD tablet
Sodium bicarb 325 mg tablet0.04USD tablet
Sodium bicarb 7.5% vial0.04USD ml
Sodium bicarbonate powder0.03USD g
Sodium bicarb 8.4% vial0.02USD ml
Sodium bicarbonate 5% inj0.02USD ml
Colyte with flavor packets0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5840737 No1996-07-152016-07-15Us
US5945449 No1997-10-312017-10-31Us
US6489346 No1996-07-162016-07-16Us
US6645988 No1996-07-162016-07-16Us
US6699885 No1996-07-162016-07-16Us
US6780882 No1996-07-152016-07-15Us
US7084130 No2001-11-292021-11-29Us
US7291324 No2002-10-222022-10-22Us
US7300674 No2003-03-042023-03-04Us
US7399772 No1996-07-152016-07-15Us
USRE45198 No1996-07-162016-07-16Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting pointDecomposes around 50 °CNot Available
water solubility1E+005 mg/L (at 25 °C)MERCK INDEX (1996)
pKa6.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility764.0 mg/mLALOGPS
logP-0.06ALOGPS
logP0.25ChemAxon
logS0.96ALOGPS
pKa (Strongest Acidic)6.05ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity20.34 m3·mol-1ChemAxon
Polarizability3.86 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9292
Blood Brain Barrier+0.936
Caco-2 permeable-0.5321
P-glycoprotein substrateNon-substrate0.8785
P-glycoprotein inhibitor INon-inhibitor0.9903
P-glycoprotein inhibitor IINon-inhibitor0.9931
Renal organic cation transporterNon-inhibitor0.9563
CYP450 2C9 substrateNon-substrate0.8326
CYP450 2D6 substrateNon-substrate0.9017
CYP450 3A4 substrateNon-substrate0.8144
CYP450 1A2 substrateNon-inhibitor0.9053
CYP450 2C9 inhibitorNon-inhibitor0.9337
CYP450 2D6 inhibitorNon-inhibitor0.9401
CYP450 2C19 inhibitorNon-inhibitor0.9461
CYP450 3A4 inhibitorNon-inhibitor0.9774
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9911
Ames testNon AMES toxic0.9285
CarcinogenicityNon-carcinogens0.5181
BiodegradationReady biodegradable0.9636
Rat acute toxicity1.9204 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9596
hERG inhibition (predictor II)Non-inhibitor0.9866
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic carbonic acids and derivatives
Sub ClassOrganic carbonic acids
Direct ParentOrganic carbonic acids
Alternative Parents
Substituents
  • Carbonate salt
  • Carbonic acid
  • Organic alkali metal salt
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organic sodium salt
  • Organic salt
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors

Targets

1. Hydrogen ions
Kind
Small molecule
Organism
Pharmacological action
yes
Actions
neutralizer
References
  1. Nudel DB, Peterson BJ, Buckley BJ, Kaplan NA, Weinhaouse E, Gootman N: Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis. Dev Pharmacol Ther. 1990;15(2):86-93. [PubMed:1964114 ]
  2. Roderick P, Willis NS, Blakeley S, Jones C, Tomson C: Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD001890. [PubMed:17253467 ]
  3. Balali-Mood M, Balali-Mood K: Neurotoxic disorders of organophosphorus compounds and their managements. Arch Iran Med. 2008 Jan;11(1):65-89. [PubMed:18154426 ]
  4. Vaughan-Jones RD, Spitzer KW: Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte. Biochem Cell Biol. 2002;80(5):579-96. [PubMed:12440699 ]
  5. Levraut J, Giunti C, Ciebiera JP, de Sousa G, Ramhani R, Payan P, Grimaud D: Initial effect of sodium bicarbonate on intracellular pH depends on the extracellular nonbicarbonate buffering capacity. Crit Care Med. 2001 May;29(5):1033-9. [PubMed:11378618 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.Isoform 2: May have a higher activity than isoform 1.
Gene Name:
SLC4A4
Uniprot ID:
Q9Y6R1
Molecular Weight:
121459.38 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.
Gene Name:
SLC4A7
Uniprot ID:
Q9Y6M7
Molecular Weight:
136042.595 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediate...
Gene Name:
SLC4A8
Uniprot ID:
Q2Y0W8
Molecular Weight:
122936.66 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alteration...
Gene Name:
SLC4A5
Uniprot ID:
Q9BY07
Molecular Weight:
126254.04 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).
Gene Name:
SLC4A10
Uniprot ID:
Q6U841
Molecular Weight:
125945.115 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Comments
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Drug created on July 08, 2007 10:59 / Updated on April 25, 2017 04:16