Identification
NameSodium bicarbonate
Accession NumberDB01390
TypeSmall Molecule
GroupsApproved
Description

Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Structure
Thumb
Synonyms
Baking soda
Bicarbonate of soda
Carbonic acid monosodium salt
e 500
e-500
e500
NaHCO3
Natriumhydrogenkarbonat
Sodium acid carbonate
Sodium bicarbonate
Sodium hydrogen carbonate
Sodium hydrogencarbonate
External IDs B1654 / E-500(II) / INS NO.500(II) / INS-500(II)
Product Ingredients Not Available
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
800 Sodium Bicarbonate PowderPowder, for solution650 gHemodialysisBaxter Laboratories1988-12-31Not applicableCanada
BibagPowder, for solution650 gHemodialysisFresenius Medical Care Deutchland Gmbh2009-12-10Not applicableCanada
Bicarb Hemodial Conc 81.25gm/lLiquid81.25 gHemodialysisBicarbolyte Corporation1986-12-311998-06-08Canada
Bicarbolyte Bicar Hemodialysis ConcLiquid72 gHemodialysisBicarbolyte Corporation1986-12-311998-06-08Canada
Bicarbonate Conc Mb-330 Pwr 650mg/pckPowder650 gHemodialysisRenal Systems, Division Of Minntech Corp.1985-12-311998-11-02Canada
Bicarbonate Concentrate 4105Liquid80.68 gHemodialysisBaxter Laboratories1988-12-312002-08-01Canada
Bicarbonate Concentrate B38Solution80.7 gHemodialysisChief Medical Supplies Ltd2005-07-04Not applicableCanada
Bicarbonate Concentrate D17000Solution81.3 gHemodialysisBaxter Laboratories1986-12-31Not applicableCanada
BicartPowder650 gHemodialysisBaxter Laboratories1990-12-31Not applicableCanada
BicartPowder720 gHemodialysisBaxter Laboratories2013-09-26Not applicableCanada
BicartPowder1250 gHemodialysisBaxter Laboratories2013-10-22Not applicableCanada
Biflexy 1100Powder, for solution1100 gHemodialysisBellco SrlNot applicableNot applicableCanada
Biflexy 750Powder, for solution750 gHemodialysisBellco SrlNot applicableNot applicableCanada
Biflexy 900Powder, for solution900 gHemodialysisBellco Srl2016-08-08Not applicableCanada
D12057Powder, for solution650 gHemodialysisBio Pharm, Inc.1988-12-311996-09-09Canada
Hema Bp-38Powder6 kgHemodialysisChief Medical Supplies Ltd2006-07-03Not applicableCanada
HemacartPowder, for solution650 gHemodialysisChief Medical Supplies Ltd2009-12-21Not applicableCanada
Naturalyte Dry Pack for Bicarbonate DialysisPowder650 gHemodialysisFresenius Medical Care North America1998-04-142016-07-26Canada
Naturalyte Sodium Bicarbonate Liquid ConcentrateLiquid81.25 gHemodialysisFresenius Medical Care Korea1997-04-142017-01-10Canada
Sodium BicarbonateInjection, solution84 mg/mLIntravenousMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2010-05-03Not applicableUs
Sodium Bicarbonate 5% Inj 50mg/ml USPLiquid50 mgIntravenousMcgaw Inc.1993-12-311997-08-15Canada
Sodium Bicarbonate 5% Inj 5gm/100ml USPSolution5 gIntravenousBaxter Laboratories1991-12-312011-05-10Canada
Sodium Bicarbonate Dry Concentrate Ro9504Powder, for solution672 gHemodialysisGenpharm Ulc1990-12-312003-07-23Canada
Sodium Bicarbonate Dry Concentrate Rx002cPowder650 gHemodialysisGenpharm Ulc1996-10-102004-07-30Canada
Sodium Bicarbonate Inj 4.2%Liquid42 mgIntravenousInternational Medication Systems, Limited1971-12-311997-08-15Canada
Sodium Bicarbonate Inj 7.5%Liquid75 mgIntravenousInternational Medication Systems, Limited1971-12-311997-08-15Canada
Sodium Bicarbonate Inj 8.4%Liquid84 mgIntravenousInternational Medication Systems, Limited1971-12-311997-08-15Canada
Sodium Bicarbonate Injection 75mg/mlSolution75 mgIntravenousAstra Zeneca1986-12-312004-10-14Canada
Sodium Bicarbonate Injection 84mg/mlLiquid84 mgIntravenousAstra Zeneca1986-12-312004-02-27Canada
Sodium Bicarbonate Injection USPSolution75 mgIntravenousPfizer1979-12-31Not applicableCanada
Sodium Bicarbonate Injection USPSolution84 mgIntravenousPfizer1974-12-31Not applicableCanada
Sodium Bicarbonate Injection USPSolution42 mgIntravenousPfizer1987-12-31Not applicableCanada
Sodium Bicarbonate USP for Hemodialysis D12276Powder650 gHemodialysisBaxter Laboratories1996-09-10Not applicableCanada
Sol-cart BPowder, for solution760 gHemodialysisB. Braun Avitum AgNot applicableNot applicableCanada
Sol-cart BPowder, for solution1100 gHemodialysisB. Braun Avitum AgNot applicableNot applicableCanada
Sol-cart BPowder, for solution650 gHemodialysisB. Braun Avitum AgNot applicableNot applicableCanada
Tqm Bicarbonate Concentrate B38Solution80.7 gHemodialysisTqm Enterprises LimitedNot applicableNot applicableCanada
Vivia BicarbPowder, for solution750 gHemodialysisBaxter LaboratoriesNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sodium BicarbonateInjection, solution42 mg/mLIntravenousHospira, Inc.1984-01-27Not applicableUs
Sodium BicarbonateInjection, solution42 mg/mLIntravenousHospira, Inc.2017-01-01Not applicableUs
Sodium BicarbonateInjection, solution75 mg/mLIntravenousHospira, Inc.2006-05-18Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousGeneral Injectables & Vaccines2010-08-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousHospira, Inc.2006-05-18Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
After Bite KidsLiquid5 g/100gTopicalTender Corporation2014-11-26Not applicableUs
After Bite SensitiveLiquid5 g/100gTopicalTender Corporation2014-11-26Not applicableUs
After Bite the Itch EraserLiquid50 mg/mLTopicalTender Corporation2014-09-02Not applicableUs
After Bite The Itch Eraser KIDSLiquid5 g/100gTopicalTender Corporation2014-11-262016-10-29Us
Anti-EmpachoLiquid525 mg/15mLOralMenper Distributors2012-02-21Not applicableUs
Arm and Hammer Baking SodaPowder, for solution1 g/gOralChurch & Dwight Company, Inc.2000-01-01Not applicableUs
Assured Bug Bite ReliefLiquid5 g/100gTopicalShanghai Weierya Daily Chemicals Factory2015-11-10Not applicableUs
Baking Soda USPPowder100 %OralRegal Pharms, Division Of Bradcan Corporation1987-12-311996-12-16Canada
Brioschi Effervescent AntacidGranule, effervescent1.02 g/5gOralNeobourne Pharma Lp2015-06-30Not applicableUs
Brioschi Effervescent Antacid - 1.8gm/6gmGranule, effervescent1.8 gOralBrioschi, Inc.1998-05-142003-02-14Canada
Brioschi Effervescent Antacid Pwr 280.3mg/gmGranule, effervescent269 mgOralBrioschi, Inc.1910-12-312003-02-14Canada
De La Cruz DesempachoLiquid525 mg/15mLOralDLC Laboratories, Inc.2012-08-06Not applicableUs
De LA Cruz Sodium Bicarbonate AntacidPowder2.6 g/2.6gOralDLC Laboratories, Inc.2013-09-25Not applicableUs
EcoDent Ultimate Essential Mouthcare Sparkling Clean MintLiquid25 mg/mLOralLotus Brands, Inc.2013-06-01Not applicableUs
EcoDent Ultimate Essential Mouthcare Spicy-Cool CinnamonLiquid25 mg/mLOralLotus Brands, Inc.2013-06-01Not applicableUs
Goongsecret Calming Bath Oriental Formula for BabiesPowder165 g/300gTopical0to7 Inc2013-07-012017-08-17Us
Humco Sodium BicarbonatePowder1000 mg/gOralHumco Holding Group. Inc.1998-03-25Not applicableUs
Skin protectantLiquid5 g/100gTopicalShanghai Kejing Cleaning Products Co., Ltd.2016-01-18Not applicableUs
Sodium BicarbonateTablet, orally disintegrating650 mg/1OralRising Pharmaceuticals2017-02-01Not applicableUs
Sodium BicarbonateTablet, orally disintegrating650 mg/1OralA S Medication Solutions2012-06-262017-06-20Us
Sodium BicarbonateTablet, orally disintegrating650 mg/1OralAvera Mc Kennan Hospital2015-03-05Not applicableUs
Sodium BicarbonateTablet325 mg/1OralRugby2010-04-21Not applicableUs
Sodium BicarbonatePowder100 %Oral; TopicalLab Valmo EnregistrÉ, Division Of Technilab Inc.1981-12-311999-09-17Canada
Sodium BicarbonateTablet, orally disintegrating650 mg/1OralRising Pharmaceuticals2012-06-262017-07-21Us
Sodium BicarbonateTablet, orally disintegrating650 mg/1OralAphena Pharma Solutions Tennessee, Inc.2012-06-26Not applicableUs64980 0182 10 nlmimage10 e74af3d7
Sodium BicarbonateTablet650 mg/1OralRugby2010-03-08Not applicableUs00536 4544 10 nlmimage10 3d0e9e84
Sodium BicarbonateTablet650 mg/1OralMirror Pharmaceuticals LLC2011-01-24Not applicableUs
Sodium Bicarbonate 10 grTablet648 mg/1OralReliable 1 Laboratories2015-11-01Not applicableUs
Sodium Bicarbonate 5 grTablet324 mg/1OralReliable 1 Laboratories2015-11-01Not applicableUs
Sodium Bicarbonate AntacidTablet650 mg/1OralCardinal Health2010-03-08Not applicableUs
Sodium Bicarbonate AntacidTablet325 mg/1OralRugby2015-03-25Not applicableUs
Sodium Bicarbonate AntacidPowder1 g/gOralCompania Farmaceutica, s.a. De c.v.2017-02-16Not applicableUs
Sodium Bicarbonate AntacidTablet650 mg/1OralRugby2015-03-25Not applicableUs
Sodium Bicarbonate AntacidPowder2.6 g/2.6gOralDannso corp./d.b.a. Essential Products2013-09-25Not applicableUs
Sodium Bicarbonate Tab 300mgTablet300 mgOralD.C. Labs Limited1951-12-312003-07-11Canada
Sodium Bicarbonate Tab 600mgTablet600 mgOralD.C. Labs Limited1951-12-312003-07-11Canada
The Itch Eraser SensitiveCream50 mg/gTopicalTender Corporation2015-11-17Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Assured Bug Bite ReliefLiquid5 g/100gTopicalShanghai Weierya Daily Chemicals Factory2015-11-10Not applicableUs
NeutInjection, solution.2 g/5mLIntravenousGeneral Injectables & Vaccines2014-07-31Not applicableUs
Neut Sodium BicarbonateInjection, solution.2 g/5mLIntravenousCardinal Health2005-08-22Not applicableUs
Neut Sodium BicarbonateInjection, solution.2 g/5mLIntravenousHospira, Inc.2005-08-22Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousMesource Pharmaceuticals2014-07-03Not applicableUs
Sodium BicarbonateInjection, solution42 mg/mLIntravenousCardinal Health1984-01-27Not applicableUs
Sodium BicarbonateInjection, solution75 mg/mLIntravenousGeneral Injectables & Vaccines2011-03-10Not applicableUs
Sodium BicarbonateInjection, solution42 mg/mLIntravenousGeneral Injectables & Vaccines2010-03-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousHospira, Inc.1985-05-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousHospira, Inc.1985-04-18Not applicableUs
Sodium BicarbonateSolution42 mg/mLIntravenousAPP Pharmaceuticals, Inc.2000-08-10Not applicableUs
Sodium BicarbonateSolution84 mg/mLParenteralOnpharma, Inc.2010-07-22Not applicableUs
Sodium BicarbonateInjection, solution75 mg/mLIntravenousHospira, Inc.1985-02-14Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousRemedy Repack2015-03-072016-03-29Us
Sodium BicarbonateInjection, solution84 mg/mLIntravenousCardinal Health1985-05-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousCardinal Health1985-04-18Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousGeneral Injectables & Vaccines2010-08-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousHospira, Inc.1984-04-13Not applicableUs
Sodium BicarbonateTablet650 mg/1OralCardinal Health2011-06-06Not applicableUs
Sodium BicarbonateInjection, solution44.6 meq/50mLIntravenousGeneral Injectables & Vaccines2010-08-012017-02-02Us
Sodium BicarbonateInjection84 mg/mLIntravenousInternational Medication Systems, Limited2000-06-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousFresenius Kabi2000-08-102017-08-11Us
Sodium BicarbonateInjection, solution84 mg/mLIntravenousCardinal Health1985-04-18Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousGeneral Injectables & Vaccines2010-08-01Not applicableUs
Sodium BicarbonateInjection, solution84 mg/mLIntravenousCardinal Health1985-04-182019-03-31Us
Sodium BicarbonateInjection, solution84 mg/mLIntravenousA S Medication Solutions1985-04-182017-06-20Us
Sodium BicarbonateInjection84 mg/mLParenteralAmphastar Pharmaceuticals, Inc.2000-06-012016-12-06Us
International BrandsNot Available
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Accusol 35 K0SolutionHemodialysisChief Medical Supplies Ltd2007-10-31Not applicableCanada
Accusol 35 K2SolutionHemodialysisChief Medical Supplies LtdNot applicableNot applicableCanada
Accusol 35 K4SolutionHemodialysisChief Medical Supplies Ltd2007-10-31Not applicableCanada
Alka SeltzerTablet, effervescentOralSalimex, S.A.2012-10-10Not applicableUs
Alka Seltzer EvtTablet, effervescentOralMiles Inc. Pharmaceutical Division1977-12-311996-09-09Canada
Alka Seltzer FlavouredTablet, effervescentOralMiles Inc. Pharmaceutical Division1986-12-311996-09-09Canada
Alka Seltzer OriginalTabletOralNavajo Manuracturing Company2016-09-16Not applicableUs
Alka-seltzerTablet, effervescentOralBayer Inc Consumer Care1995-12-31Not applicableCanada
Alka-Seltzer Extra StrengthGranule, effervescentOralBayer Health Care Llc.2011-04-11Not applicableUs
Alka-seltzer FlavouredTablet, effervescentOralBayer Inc Consumer Care2002-09-10Not applicableCanada
Alka-seltzer Flavoured - EvtTablet, effervescentOralBayer Inc Consumer Care1995-12-312004-06-28Canada
Alka-Seltzer GoldTablet, effervescentOralBayer Health Care Llc.2014-11-19Not applicableUs
Alka-Seltzer HEARTBURNGranule, effervescentOralBayer Health Care Llc, Consumer Care2010-03-022017-08-24Us
Alka-Seltzer Lemon LimeTablet, effervescentOralBayer Health Care Llc.2014-11-07Not applicableUs
Alka-Seltzer OriginalTablet, effervescentOralBayer Health Care Llc.2010-03-02Not applicableUs
Alka-Seltzer XTRA STRENGTHGranule, effervescentOralBayer Health Care Llc, Consumer Care2010-03-022017-01-26Us
Amo Endosol ExtraPowder, for solutionIntraocularAmo Canada Company1993-12-312008-07-30Canada
Baros Effervescent GranulesGranule, effervescentOralTyco Healthcare1988-12-312010-01-07Canada
Bc-I Concentrate PwrPowder, for solutionHemodialysisRenal Systems, Division Of Minntech Corp.1985-12-311998-11-02Canada
Bi-peglyteKit; Powder, for solution; Tablet, delayed releaseOralPendopharm Division Of De Pharmascience Inc2010-06-06Not applicableCanada
Bicarbolyte Bicar Hemodialysis ConcLiquidHemodialysisBicarbolyte Corporation1986-12-311998-06-08Canada
Bicarbolyte Bicar Hemodiaylsis ConcLiquidHemodialysisBicarbolyte Corporation1986-12-311998-06-08Canada
Bicarbonate Chloride D12052Powder, for solutionHemodialysisBaxter Laboratories1986-12-312002-08-01Canada
Bicarbonate Concentrate D16000SolutionHemodialysisBaxter Laboratories1986-12-312007-08-02Canada
Bicarbonate Concentrate D16001SolutionHemodialysisBaxter Laboratories1986-12-312007-08-02Canada
Bicarbonate Concentrate D20000LiquidHemodialysisBaxter Laboratories1989-12-312002-08-01Canada
Bicarbonate Concentrate No 4202 LiqLiquidHemodialysisWestern Dialysis Supplies Ltd.1992-12-311996-09-09Canada
Bicart Select Combi-pakKit; Powder, for solutionHemodialysisBaxter Laboratories2016-02-22Not applicableCanada
BicaruvasPowder, for solutionOralProsana Distribuciones, S.A. De C.V.2013-04-23Not applicableUs
Bicavera 1.5% GlucoseSolutionHemodialysisFresenius Medical Care KoreaNot applicableNot applicableCanada
Bicavera 2.3% GlucoseSolutionHemodialysisFresenius Medical Care KoreaNot applicableNot applicableCanada
Bicavera 4.25% GlucoseSolutionHemodialysisFresenius Medical Care KoreaNot applicableNot applicableCanada
Bicavera Forte 1.5% GlucoseSolutionHemodialysisFresenius Medical Care KoreaNot applicableNot applicableCanada
Bicavera Forte 2.3% GlucoseSolutionHemodialysisFresenius Medical Care KoreaNot applicableNot applicableCanada
Bicavera Forte 4.25% GlucoseSolutionHemodialysisFresenius Medical Care KoreaNot applicableNot applicableCanada
Brioschi Childrens Effervescent AntacidGranule, effervescentOralBrioschi, Inc.2011-04-272016-04-05Us
Brioschi Effervescent AntacidGranule, effervescentOralBrioschi, Inc.2010-09-202016-04-05Us
Bromo SeltzerGranuleOralTower Laboratories Ltd2000-08-212009-08-31Canada
Bss PlusKitAlcon, Inc.1982-06-282017-05-31Us
Carbicarb InjectionLiquidIntravenousInternational Medication Systems, Limited1992-12-311997-08-15Canada
Ceo-twoSuppositoryRectalBeutlich L.P.2008-08-15Not applicableUs
Ceo-two Bowel Evacuant SuppositoriesSuppositoryRectalBeutlich L.P.2000-04-072003-07-30Canada
Citrocarbonate Eff PwsGranule, effervescentOralRoberts Pharmaceutical1992-12-311999-03-31Canada
ColytePowder, for solutionNasogastric; OralPendopharm Division Of De Pharmascience Inc1986-12-31Not applicableCanada
Colyte with flavor packsPowder, for solutionNasogastric; OralAlaven Pharmaceutical1999-04-07Not applicableUs
CvsPowderNasalCvs Health2013-04-01Not applicableUs
CVS Health Antacid and Pain RelieverTablet, effervescentOralCvs Health2006-12-01Not applicableUs
DialytePowder, for solutionOralIamat (Inter Assoc Medic Assist Travel)1985-12-311997-07-07Canada
E-Z-gas 2 GranulesPowderOralTherapex Division De E Z Em Canada Inc1985-12-312000-04-13Canada
Effervescent Antacid and Pain ReliefTablet, effervescentOralCardinal Health2006-12-01Not applicableUs
Effervescent Pain ReliefTablet, effervescentOralWestern Family Foods2008-01-28Not applicableUs
Effervescent Pain Relief Fast ReliefTablet, effervescentOralDeseret Laboratories, Inc.2006-09-22Not applicableUs
Effervescent Pain Relief Fast Relief Fast ReliefTablet, effervescentOralMajor1996-04-26Not applicableUs
Electropeg SolutionPowderOralTechnilab Pharma Inc.1998-04-201999-09-27Canada
EstomarolPowderOralLaboratorios Imperiales, S.A. De C.V.2011-05-11Not applicableUs
GaviLyte - C TMPowder, for solutionOralGavis Pharmaceuticals, LLC.2009-06-01Not applicableUs
GaviLyte - NPowder, for solutionOralGavis Pharmaceuticals, LLC.2009-05-28Not applicableUs
GaviLyte G TMPowder, for solutionOralLupin Pharmaceuticals2009-06-01Not applicableUs
Gingera Effervescent AntacidGranule, effervescentOralBrioschi, Inc.2011-04-292016-04-05Us
GoLYTELYPowder, for solutionOralBraintree Laboratories1984-07-13Not applicableUs
Golytely Gi Lavage SolutionPowder, for solutionOralBraintree Laboratories1985-12-31Not applicableCanada
Good Sense Omeprazole and Sodium BicarbonateCapsule, gelatin coatedOralL. Perrigo Company2017-06-19Not applicableUs
H.E.L.P.bicelSolutionHemodialysisB. Braun Avitum Ag2012-03-09Not applicableCanada
InonGranuleOralSato Pharmaceutical1989-05-31Not applicableUs
Jamp-electropegPowder, for solutionOralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-electropeg With Flavour PacketPowder, for solutionOralJamp Pharma CorporationNot applicableNot applicableCanada
JamplytePowderOralJamp Pharma CorporationNot applicableNot applicableCanada
Jamplyte 280PowderOralJamp Pharma CorporationNot applicableNot applicableCanada
Kettle Neti PotPowder, for solutionOralCardinal Health 414, Llc2013-04-01Not applicableUs
Klean-prepPowder, for solutionOralRichmond Pharmaceuticals1988-12-311999-08-09Canada
Leader Sinus Wash Saline RefillsPowder, for solutionNasalCardinal Health 414, Llc2013-04-01Not applicableUs
LyteprepPowderOralTherapex Division De E Z Em Canada Inc2000-01-252005-09-26Canada
Medique Medi SeltzerTablet, effervescentOralUnifirst First Aid2008-12-30Not applicableUs
NavstelKit; SolutionIntraocular; IrrigationAlcon, Inc.Not applicableNot applicableCanada
Neutra-seltzerTablet, effervescentOralTeva2011-01-01Not applicableCanada
Normo GastrylTablet, effervescentOralSabex Inc1973-12-312009-11-24Canada
Normocarb 25SolutionHemodialysisDialysis Solutions Inc.2006-09-222013-08-02Canada
Normocarb 35SolutionHemodialysisDialysis Solutions Inc.2001-03-212013-08-02Canada
Not ApplicableCapsuleOralSterling Knight Pharmaceuticals, Llc2017-07-13Not applicableUs
NuLYTELYPowder, for solutionOralPhysicians Total Care, Inc.2001-07-19Not applicableUs
Ocl SolutionSolutionOralAbbott1988-12-312007-07-31Canada
Ohta's Isan Stomach PowderPowderOralMaizun Calber (Canada) Ltd.1997-06-201999-08-28Canada
Ohtas Isan AntacidTabletOralOhta's Isan Co., Ltd2000-11-16Not applicableUs
Omeprazole and Sodium BicarbonatePowder, for suspensionOralOceanside Pharmaceuticals2004-06-15Not applicableUs
Omeprazole and Sodium BicrabonateCapsuleOralDr Reddy's Laboratories2016-07-15Not applicableUs
Omeprazole Sodium BicarbonateCapsuleOralCipla Limited2016-12-07Not applicableUs
Omeprazole/sodium BicarbonateCapsuleOralPrasco, Laboratories2006-02-27Not applicableUs
Ora Rinse LiqLiquid; MouthwashOralThompson Mckay Pharms Ltd.1991-12-311997-10-01Canada
Pain Relief Fast ReliefTablet, effervescentOralSelect Brand2006-10-23Not applicableUs
PEG-3350 and ElectrolytesPowder, for solutionOralAffordable Pharmaceuticals, LLC2009-07-01Not applicableUs
PEG-3350, sodium chloride, sodium bicarbonate and potassium chloridePowder, for solutionOralAffordable Pharmaceuticals, LLC2013-02-08Not applicableUs
Peglyte PowderPowder, for solutionOralPendopharm Division Of De Pharmascience Inc1988-12-31Not applicableCanada
Peglyte SolutionLiquidOralPharmascience Inc1989-12-312012-07-13Canada
PepsotolTabletOralHerbes Universelles Inc.1966-12-312009-07-15Canada
Phoxillum Bk4/2.5SolutionIntravenousBaxter Laboratories2015-01-13Not applicableUs
Physioneal 40 Glucose 1.36% W/V 13.6mg/ml Clear-flexSolutionHemodialysisBaxter Laboratories2013-02-06Not applicableCanada
Physioneal 40 Glucose 1.36% W/V 13.6mg/ml Solution for Peritoneal DialysisSolutionHemodialysisBaxter Laboratories2003-08-05Not applicableCanada
Physioneal 40 Glucose 2.27% W/V 22.7 mg/ml Clear-flexSolutionHemodialysisBaxter Laboratories2013-02-06Not applicableCanada
Physioneal 40 Glucose 2.27% W/V 22.7 mg/ml, Solution for Peritoneal DialysisSolutionHemodialysisBaxter Laboratories2003-08-05Not applicableCanada
Physioneal 40 Glucose 3.86% W/V 38.6 mg/ml Clear-flexSolutionHemodialysisBaxter Laboratories2013-02-06Not applicableCanada
Physioneal 40 Glucose 3.86% W/V 38.6mg/ml, Solution for Peritoneal DialysisSolutionHemodialysisBaxter Laboratories2003-08-05Not applicableCanada
Picot Plus EffervescentPowderOralBristol Myers Squibb De Mexico, S. De R.L. De C. V.2010-05-282016-10-13Us
Pleo Alkala AntacidPowderOralSanum Kehlbeck Gmbh & Co Kg1996-12-19Not applicableUs
Polyethylene Glycol 3350 and ElectrolytesPowder, for solutionOralMylan Pharmaceuticals2010-02-022016-01-14Us
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride - UnflavoredPowder, for solutionOralStrides Shasun Limited2015-04-14Not applicableUs
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride with Lemon FlavorPowder, for solutionOralStrides Shasun Limited2015-04-14Not applicableUs
Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride with Orange FlavorPowder, for solutionOralStrides Shasun Limited2015-04-14Not applicableUs
Polyethylene Glycol-3350 and ElectrolytesPowder, for solutionOralNovel Laboratories, Inc.2009-06-01Not applicableUs
Polyethylene Glycol-3350 and Electrolytes with Flavor PackPowder, for solutionOralNovel Laboratories, Inc.2009-06-01Not applicableUs
Polyethylene Glycol-3350, Sodium Chloride, Potassium Chloride and Sodium BicarbonatePowder, for solutionOralNovel Laboratories, Inc.2009-05-28Not applicableUs
Premier Value Antacid and Pain Relief MedicineTablet, effervescentOralChain Drug Consortium2006-05-292018-03-31Us
Prism0calSolutionHemodialysis; IntravenousBaxter Laboratories2005-12-24Not applicableCanada
Prism0cal B22k0/0SolutionHemodialysis; IntravenousBaxter Laboratories2016-06-18Not applicableCanada
Prismasol 0SolutionHemodialysis; IntravenousBaxter Laboratories2001-01-01Not applicableCanada
Prismasol 2SolutionHemodialysis; IntravenousBaxter Laboratories2006-02-21Not applicableCanada
Prismasol 4SolutionHemodialysis; IntravenousBaxter Laboratories2006-02-21Not applicableCanada
Prolax - PwsPowder, for solutionOralRivex Pharma Inc.1997-04-212007-10-15Canada
R04940 LiqLiquidHemodialysisBdh Inc.1987-12-312000-08-03Canada
Relief OTC antacidLiquidOralTummy Company, Inc.2014-05-28Not applicableUs
Riga Purgative Lemon Flav LiqLiquidOralGlendale Agencies1978-12-311996-11-29Canada
Sal de Uvas PicotGranule, effervescentOralReckitt Benckiser Mexico, s.a. De c.v.2016-03-31Not applicableUs
Saline RefillsPowder, for solutionOralCardinal Health 414, Llc2013-04-01Not applicableUs
Saline WashPowder, for solutionOralTarget Corporation.2013-04-01Not applicableUs
SinuCleansePowder, for solutionNasalAscent Consumer Products, Inc.2015-02-01Not applicableUs
SinuCleanse Micro-Filtered Nasal Wash SystemKitAscent Consumer Products, Inc.2015-07-01Not applicableUs
SinuCleanse Neti-PotKitNasalAscent Consumer Products, Inc.2015-02-01Not applicableUs
SinuCleanse SqueezeKitNasalAscent Consumer Products, Inc.2015-02-01Not applicableUs
Sinus WashPowder, for solutionNasalCvs Health2013-04-01Not applicableUs
Soda Mint TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-311997-08-08Canada
Sodium Bicarbonate-chloride Dry ConcentratePowderHemodialysisGenpharm Ulc2000-07-072004-07-30Canada
Sodium Bicarbonate-chloride Dry Concentrate R04955PowderHemodialysisGenpharm Ulc1988-12-312004-07-30Canada
Sodium Bicarbonate-chloride Liquid Concentrate Ro4941LiquidHemodialysisGenpharm Ulc1987-12-312004-07-30Canada
Solution CardaLiquidOralLaboratoire Atlas Inc1984-12-311996-09-09Canada
Stomachin AntacidCapsuleOralChang Kuo Chou Pharmaceutical Co. Ltd.2009-04-30Not applicableUs
Thunas BilexLiquidOralThuna Herbal Remedies Ltd.1979-12-312002-10-16Canada
Top Value Effervescent Pain ReliefTablet, effervescentOralTower Laboratories Ltd2006-12-01Not applicableUs
Topcare Omeprazole and Sodium BicarbonateCapsule, gelatin coatedOralTopco Associates2017-03-13Not applicableUs
TriLyte with Flavor PacksPowder, for solutionNasogastric; OralWallace Pharmaceuticals Inc.2013-09-23Not applicableUs
Unik Zoru PwrPowderOralTherapex Division De E Z Em Canada Inc1981-12-312000-08-01Canada
Unik Zoru TabTabletOralTherapex Division De E Z Em Canada Inc1981-12-312004-06-10Canada
Urasal GranulesGranule, effervescentOralAxxess Pharma Inc.1951-12-312011-07-22Canada
Vida Mia Pain ReliefTablet, effervescentOralNavarro Discount Pharmacies, LLC2012-08-13Not applicableUs
Walgreens Filtered Squeeze Sinus Wash SystemKitWalgreen2015-07-01Not applicableUs
Walgreens Sinus Wash Squeeze Bottle KitKitWalgreen2017-04-14Not applicableUs
Well at WalgreensKitNasalWalgreen2013-04-01Not applicableUs
WinCo Foods Effervescent Antacid and Pain ReliefTablet, effervescentOralWin Co Foods, Llc,2015-01-01Not applicableUs
Woodward's Gripe Water LiqLiquidOralW Woodwards C/O Lrc International1991-12-311997-08-07Canada
Yeti Pot- Schnoz WashGranule, for solutionNasalHealthland Llc2016-05-01Not applicableUs
Zee-Seltzer Antacid and Pain RelieverTablet, effervescentOralZee Medical Inc2006-08-14Not applicableUs
ZegeridCapsuleOralPhysicians Total Care, Inc.2006-06-08Not applicableUs
Zegerid OTCCapsuleOralBayer2010-04-01Not applicableUs
Categories
UNII8MDF5V39QO
CAS number144-55-8
WeightAverage: 84.0066
Monoisotopic: 83.982338573
Chemical FormulaCHNaO3
InChI KeyUIIMBOGNXHQVGW-UHFFFAOYSA-M
InChI
InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
IUPAC Name
sodium hydrogen carbonate
SMILES
[Na+].OC([O-])=O
Pharmacology
Indication

Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.

Structured Indications
Pharmacodynamics

Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis.

Mechanism of action

Sodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. [PharmGKB]

TargetKindPharmacological actionActionsOrganismUniProt ID
Hydrogen ionsSmall moleculeyes
neutralizer
not applicabledetails
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium bicarbonate.Approved, Vet Approved
FlecainideSodium bicarbonate may decrease the arrhythmogenic activities of Flecainide.Approved, Withdrawn
LithiumSodium bicarbonate may increase the excretion rate of Lithium which could result in a lower serum level and potentially a reduction in efficacy.Approved
Food InteractionsNot Available
References
Synthesis Reference

Alan B. Gancy, Rustom P. Poncha, "Production of low bulk density product from sodium bicarbonate by the use of an inert gas stream." U.S. Patent US3984527, issued August, 1922.

US3984527
General ReferencesNot Available
External Links
ATC CodesB05XA02 — Sodium bicarbonateB05CB04 — Sodium bicarbonate
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceTransplantation, Kidney1
0CompletedTreatmentPulmonary Ventilation1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedPreventionChronic Kidney Disease (CKD)1
1CompletedTreatmentAcid Reflux / Gastro Oesophageal Reflux Disease1
1CompletedTreatmentGastric Emptying / Healthy Volunteers1
1CompletedTreatmentHeartburn1
1CompletedTreatmentMalignant Neoplasm of Pancreas1
1CompletedTreatmentNeoplasms, Malignant1
1RecruitingOtherHealthy Volunteers1
1RecruitingTreatmentChronic Kidney Disease (CKD) / Metabolic Acidosis / Sickle Cell Disorders1
1TerminatedSupportive CareCancers / Malignancies, Hematologic / Malignant Lymphomas / Malignant Solid Tumours / Multiple Myeloma (MM) / Neoplasms Metastasis / Pain / Tumors / Unresectable Malignant Neoplasm1
1Unknown StatusDiagnosticAdjunct to general anesthesia therapy1
1, 2Unknown StatusTreatmentPneumonia1
2CompletedPreventionCardiac Surgery and Cardiopulmonary Bypass1
2CompletedPreventionContrast Induced Nephropathy (CIN)2
2CompletedPreventionKidney Injury1
2CompletedPreventionRadiographic Contrast Agent Nephropathy1
2CompletedTreatmentCardiac Arrest / Metabolic Acidosis1
2CompletedTreatmentImpaired Renal Function / Oliguria / Systemic Inflammatory Response Syndrome (SIRS)1
2RecruitingNot AvailableBowel preparation therapy1
2RecruitingTreatmentAcute Kidney Injury (AKI) / Congenital Heart Disease (CHD)1
2RecruitingTreatmentAnaesthesia therapy / Local Infiltration1
2RecruitingTreatmentChronic Kidney Disease (CKD)1
2TerminatedTreatmentAcute Kidney Injury (AKI)1
2, 3CompletedPreventionContrast Induced Nephropathy (CIN)1
2, 3CompletedTreatmentChronic Kidney Disease (CKD)1
2, 3RecruitingTreatmentChronic Kidney Disease (CKD) / Metabolic Acidosis1
2, 3TerminatedPreventionCardiopulmonary Bypass / Surgery, Cardiac1
2, 3Unknown StatusDiagnosticDetection of the Correct Position of Intravenous Line1
2, 3Unknown StatusDiagnosticDrug Extravasation / Infiltration1
3Active Not RecruitingTreatmentMyocardial Injury After Noncardiac Surgery (MINS)1
3CompletedNot AvailableBowel Preparation for Colonoscopy1
3CompletedNot AvailableColonoscopy1
3CompletedNot AvailableContrast Induced Nephropathy (CIN) / Kidney Diseases1
3CompletedNot AvailableGastric Acid / Human Experimentation2
3CompletedNot AvailableIntragastric Acidity1
3CompletedNot AvailableLocal Anesthesia2
3CompletedDiagnosticBowel Preparation for Colonoscopy1
3CompletedDiagnosticBowel Preparation, Efficacy, Tolerability, Safety1
3CompletedPreventionChronic Kidney Disease (CKD)1
3CompletedPreventionRenal Failure1
3CompletedSupportive CareColon Adenomas / Colorectal Cancers1
3CompletedTreatmentCataracts2
3CompletedTreatmentColonoscopy1
3CompletedTreatmentHuman Experimentation1
3CompletedTreatmentMalignant Neoplasm of Colon1
3CompletedTreatmentOccasional Constipation1
3CompletedTreatmentReflux, Gastroesophageal1
3Not Yet RecruitingOtherDigestive System Diseases1
3RecruitingPreventionAcute Kidney Injury (AKI) / Contrast media reaction1
3RecruitingTreatmentMetabolic Acidosis1
3TerminatedPreventionContrast Induced Kidney Injury1
3TerminatedPreventionHypopharynx Cancer / Oropharynx Cancers1
3Unknown StatusDiagnosticColonoscopy1
3Unknown StatusPreventionAcute Renal Failure (ARF)1
3Unknown StatusPreventionChronic Kidney Disease (CKD)1
3Unknown StatusPreventionKidney Failures, Acute1
4CompletedNot AvailableColonoscopy1
4CompletedNot AvailableNormal Healthy Subject Population1
4CompletedPreventionContrast Induced Acute Kidney Injury1
4CompletedPreventionContrast Induced Nephropathy (CIN)2
4CompletedPreventionContrast media reaction / Kidney Diseases1
4CompletedPreventionEmergent Coronary Procedure1
4CompletedPreventionMarginal Ulcers1
4CompletedPreventionProphylaxis of Pulmonary embolism / Radiographic Contrast Agent Nephropathy1
4CompletedPreventionProphylaxis of Contrast-induced nephropathy1
4CompletedSupportive CareEnd-Stage Renal Disease (ESRD)1
4CompletedSupportive CarePain1
4CompletedTreatmentColonoscopy2
4CompletedTreatmentContrast Induced Nephropathy (CIN)1
4CompletedTreatmentErosive Esophagitis(EE)1
4CompletedTreatmentHeartburn1
4CompletedTreatmentMalignant Neoplasm of Colon1
4CompletedTreatmentPreparation for Colonoscopy1
4Enrolling by InvitationPreventionOral Mucositis1
4Enrolling by InvitationTreatmentLocal Anesthesia1
4Not Yet RecruitingDiagnosticBowel Preparation Solutions1
4RecruitingDiagnosticAnatomic renal artery stenosis / Chronic Kidney Disease (CKD) / Prophylaxis of Pulmonary embolism / Pulmonary Cancer1
4RecruitingPreventionAcute Kidney Injury (AKI)1
4RecruitingPreventionAcute Kidney Injury (AKI) / Aortic Valve Disorder / Chronic Kidney Disease (CKD) / Contrast Induced Nephropathy (CIN)1
4RecruitingTreatmentDiabetes, Diabetes Mellitus Type 1 / Diabetic Kidney Disease / Diabetic Nephropathies1
4RecruitingTreatmentSubjets Requiring a Colonoscopy1
4RecruitingTreatmentVaricosities of the great saphenous vein1
4TerminatedPreventionContrast Media / Kidney Failures, Acute1
4Unknown StatusHealth Services ResearchColonoscopy1
4Unknown StatusTreatmentContrast Induced Nephropathy (CIN)1
4Unknown StatusTreatmentSudden Cardiac Arrest1
Not AvailableActive Not RecruitingDiagnosticDiabetes Mellitus (DM)1
Not AvailableCompletedNot AvailableEffectiveness of SMS to Fix PC Interval1
Not AvailableCompletedNot AvailableSpinal Cord Injuries (SCI)1
Not AvailableCompletedNot AvailableThe Timing of Bowel Preparation in Outpatient Colonoscopy1
Not AvailableCompletedPreventionAcute Renal Failure Contrast Nephropathy1
Not AvailableCompletedPreventionContrast Induced Nephropathy (CIN)1
Not AvailableCompletedPreventionDysglycaemia / Insulin Resistance / Type 2 Diabetes Mellitus1
Not AvailableCompletedTreatmentCardiac Arrest1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / Metabolic Acidosis1
Not AvailableCompletedTreatmentHepatic Encephalopathy / Liver Cirrhosis / Portosystemic Encephalopathy / PSE1
Not AvailableCompletedTreatmentOral Hygiene1
Not AvailableNot Yet RecruitingTreatmentChronic Kidney Disease (CKD) / Metabolic Acidosis1
Not AvailableRecruitingDiagnosticColonoscopy1
Not AvailableRecruitingHealth Services ResearchAcute Kidney Injury (AKI)1
Not AvailableRecruitingScreeningColonoscopy1
Not AvailableRecruitingTreatmentChronic Renal Insufficiency / Diabetes Mellitus (DM)1
Not AvailableRecruitingTreatmentHealthy Volunteers1
Not AvailableTerminatedPreventionContrast Induced Nephropathy (CIN)1
Not AvailableTerminatedSupportive CareNeoplasm Related Pain (Acute) (Chronic)1
Not AvailableUnknown StatusDiagnosticBowel Preparation for Colonoscopy1
Not AvailableUnknown StatusDiagnosticPreserving Kidney Function in People Who Are at High Risk of Developing Contrast-induced Nephropathy1
Not AvailableUnknown StatusPreventionAcute Kidney Injury (AKI)1
Not AvailableUnknown StatusTreatmentEsophagus, Barrett / Reflux, Gastroesophageal1
Not AvailableWithdrawnScreeningPatients Undergoing Screening or Surveillance Colonoscopy1
Not AvailableWithdrawnTreatmentAltered Mental Status / AMS / HE / Hepatic Encephalopathy / Liver Cirrhosis1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
LiquidTopical50 mg/mL
LiquidTopical5 g/100g
Powder, for solutionIntraocular
LiquidOral525 mg/15mL
Powder, for solutionOral1 g/g
PowderOral100 %
Powder, for solutionHemodialysis
Kit; powder, for solution; tablet, delayed releaseOral
LiquidHemodialysis81.25 g
LiquidHemodialysis72 g
LiquidHemodialysis80.68 g
SolutionHemodialysis80.7 g
SolutionHemodialysis
SolutionHemodialysis81.3 g
LiquidHemodialysis
PowderHemodialysis1250 g
PowderHemodialysis720 g
Kit; powder, for solutionHemodialysis
Powder, for solutionHemodialysis750 g
Powder, for solutionHemodialysis900 g
Granule, effervescentOral
Granule, effervescentOral1.02 g/5g
Granule, effervescentOral1.8 g
Granule, effervescentOral269 mg
Kit; solutionIntraocular
LiquidIntravenous
SuppositoryRectal
Powder, for solutionNasogastric
Kit
PowderNasal
SolutionNasal
PowderOral2.6 g/2.6g
LiquidOral25 mg/mL
PowderTopical165 g/300g
PowderHemodialysis6 kg
Powder, for solutionHemodialysis650 g
PowderOral1000 mg/g
GranuleOral
Kit; solutionIntraocular; Irrigation
Injection, solutionIntravenous.2 g/5mL
Tablet, effervescentOral
SolutionOral
Capsule, gelatin coatedOral
Powder, for suspensionOral
Liquid; mouthwashOral
SolutionIntravenous
SolutionHemodialysis; Intravenous
LiquidOral
TabletOral
InjectionIntravenous84 mg/mL
InjectionParenteral84 mg/mL
Injection, solutionIntravenous42 mg/mL
Injection, solutionIntravenous44.6 meq/50mL
Injection, solutionIntravenous75 mg/mL
Injection, solutionIntravenous84 mg/mL
PowderOral; Topical100 %
SolutionIntravenous42 mg/mL
SolutionParenteral84 mg/mL
Tablet, orally disintegratingOral650 mg/1
TabletOral648 mg/1
TabletOral324 mg/1
LiquidIntravenous50 mg
SolutionIntravenous5 g
PowderOral1 g/g
TabletOral325 mg/1
TabletOral650 mg/1
Powder, for solutionHemodialysis672 g
LiquidIntravenous42 mg
LiquidIntravenous75 mg
LiquidIntravenous84 mg
SolutionIntravenous75 mg
SolutionIntravenous42 mg
SolutionIntravenous84 mg
TabletOral300 mg
TabletOral600 mg
PowderHemodialysis650 g
PowderHemodialysis
Powder, for solutionHemodialysis1100 g
Powder, for solutionHemodialysis760 g
CapsuleOral
PowderOral
CreamTopical50 mg/g
Powder, for solutionNasogastric; Oral
KitNasal
Powder, for solutionNasal
Powder, for solutionOral
Granule, for solutionNasal
Prices
Unit descriptionCostUnit
Golytely 236 gm Solution28.0USD bottle
Colyte 240 gm Solution26.0USD bottle
Golytely 227.1 gm Solution Packet21.85USD packet
Colyte-Flavored 240 gm Solution18.17USD bottle
Elliotts b solution ampule4.71USD ml
Sodium bicarb 4.2% vial1.45USD ml
Neut 4% vial0.92USD ml
Bss plus eye solution0.2USD ml
Sodium bicarb 650 mg tablet0.07USD tablet
Antacid 650 mg tablet0.05USD tablet
Antacid 325 mg tablet0.04USD tablet
Sodium bicarb 325 mg tablet0.04USD tablet
Sodium bicarb 7.5% vial0.04USD ml
Sodium bicarbonate powder0.03USD g
Sodium bicarb 8.4% vial0.02USD ml
Sodium bicarbonate 5% inj0.02USD ml
Colyte with flavor packets0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6489346 No1996-07-162016-07-16Us
US6699885 No1996-07-162016-07-16Us
USRE45198 No1996-07-162016-07-16Us
US6645988 No1996-07-162016-07-16Us
US7399772 No1996-07-162016-07-16Us
US5945449 No1997-10-312017-10-31Us
US7300674 No2003-03-042023-03-04Us
US7291324 No2002-10-222022-10-22Us
US5840737 No1996-07-152016-07-15Us
US6780882 No1996-07-152016-07-15Us
US7084130 No2001-11-292021-11-29Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)Decomposes around 50 °CNot Available
water solubility1E+005 mg/L (at 25 °C)MERCK INDEX (1996)
pKa6.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility764.0 mg/mLALOGPS
logP-0.06ALOGPS
logP0.25ChemAxon
logS0.96ALOGPS
pKa (Strongest Acidic)6.05ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity20.34 m3·mol-1ChemAxon
Polarizability3.86 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9292
Blood Brain Barrier+0.936
Caco-2 permeable-0.5321
P-glycoprotein substrateNon-substrate0.8785
P-glycoprotein inhibitor INon-inhibitor0.9903
P-glycoprotein inhibitor IINon-inhibitor0.9931
Renal organic cation transporterNon-inhibitor0.9563
CYP450 2C9 substrateNon-substrate0.8326
CYP450 2D6 substrateNon-substrate0.9017
CYP450 3A4 substrateNon-substrate0.8144
CYP450 1A2 substrateNon-inhibitor0.9053
CYP450 2C9 inhibitorNon-inhibitor0.9337
CYP450 2D6 inhibitorNon-inhibitor0.9401
CYP450 2C19 inhibitorNon-inhibitor0.9461
CYP450 3A4 inhibitorNon-inhibitor0.9774
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9911
Ames testNon AMES toxic0.9285
CarcinogenicityNon-carcinogens0.5181
BiodegradationReady biodegradable0.9636
Rat acute toxicity1.9204 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9596
hERG inhibition (predictor II)Non-inhibitor0.9866
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MSNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic carbonic acids and derivatives
Sub ClassOrganic carbonic acids
Direct ParentOrganic carbonic acids
Alternative ParentsCarbonate salts / Organic sodium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
SubstituentsCarbonate salt / Carbonic acid / Organic alkali metal salt / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organic sodium salt / Organic salt / Organooxygen compound / Carbonyl group
Molecular FrameworkAliphatic acyclic compounds
External Descriptorsone-carbon compound, organic sodium salt (CHEBI:32139 )

Targets

1. Hydrogen ions
Kind
Small molecule
Organism
Pharmacological action
yes
Actions
neutralizer
References
  1. Nudel DB, Peterson BJ, Buckley BJ, Kaplan NA, Weinhaouse E, Gootman N: Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis. Dev Pharmacol Ther. 1990;15(2):86-93. [PubMed:1964114 ]
  2. Roderick P, Willis NS, Blakeley S, Jones C, Tomson C: Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD001890. [PubMed:17253467 ]
  3. Balali-Mood M, Balali-Mood K: Neurotoxic disorders of organophosphorus compounds and their managements. Arch Iran Med. 2008 Jan;11(1):65-89. [PubMed:18154426 ]
  4. Vaughan-Jones RD, Spitzer KW: Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte. Biochem Cell Biol. 2002;80(5):579-96. [PubMed:12440699 ]
  5. Levraut J, Giunti C, Ciebiera JP, de Sousa G, Ramhani R, Payan P, Grimaud D: Initial effect of sodium bicarbonate on intracellular pH depends on the extracellular nonbicarbonate buffering capacity. Crit Care Med. 2001 May;29(5):1033-9. [PubMed:11378618 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.Isoform 2: May have a higher activity than isoform 1.
Gene Name:
SLC4A4
Uniprot ID:
Q9Y6R1
Uniprot Name:
Electrogenic sodium bicarbonate cotransporter 1
Molecular Weight:
121459.38 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.
Gene Name:
SLC4A7
Uniprot ID:
Q9Y6M7
Uniprot Name:
Sodium bicarbonate cotransporter 3
Molecular Weight:
136042.595 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediate...
Gene Name:
SLC4A8
Uniprot ID:
Q2Y0W8
Uniprot Name:
Electroneutral sodium bicarbonate exchanger 1
Molecular Weight:
122936.66 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alteration...
Gene Name:
SLC4A5
Uniprot ID:
Q9BY07
Uniprot Name:
Electrogenic sodium bicarbonate cotransporter 4
Molecular Weight:
126254.04 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium:bicarbonate symporter activity
Specific Function:
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).
Gene Name:
SLC4A10
Uniprot ID:
Q6U841
Uniprot Name:
Sodium-driven chloride bicarbonate exchanger
Molecular Weight:
125945.115 Da
References
  1. Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. [PubMed:17071329 ]
  2. Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. [PubMed:15014910 ]
  3. Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Minerva Urol Nefrol. 2003 Jun;55(2):131-40. [PubMed:12847417 ]
  4. Soleimani M: Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney. J Nephrol. 2002 Mar-Apr;15 Suppl 5:S32-40. [PubMed:12027220 ]
Drug created on July 08, 2007 10:59 / Updated on September 01, 2017 10:39