Androstenes

Name
Androstenes
Accession Number
DBCAT000980
Description

Unsaturated derivatives of the steroid androstane containing at least one double bond at any site in any of the rings.

Drugs
DrugDrug Description
Fluticasone propionateA glucocorticoid used to treat asthma, inflammatory pruritic dermatoses, and nonallergic rhinitis.
TestosteroneA hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause.
Loteprednol etabonateA corticosteroid used to treat allergic conjunctivitis as well as inflammation and pain after ocular surgery.
TestolactoneA medication used to treat advanced breast cancer.
ExemestaneAn aromatase inhibitor used to treat breast cancer in postmenopausal women after treatment with tamoxifen.
FluoxymesteroneA synthetic androgenic anabolic steroid that used in the treatment of hypogonadism and delayed puberty in males, as well as breast neoplasms in women.
FinasterideAn antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase.
Testosterone propionateA slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.
19-norandrostenedioneThe claim that supplemental 19-norandrostenedione has anabolic effects is unsubstantiated.
5-androstenedione5-androstenedione is a prohormone of testosterone. In the United States, the Controlled Substance Act is inclusive to anabolic steroids and their precursors. Thus 5-androstenedione is a controlled substance, and its...
BolasteroneNot Available
1-Testosterone1-Testosterone is an anabolic steroid that differs from testosterone by having a 1,2-double bond instead of 4,5-double bond in its A ring.
4-Hydroxytestosterone4-Hydroxytestosterone is testosterone substituted with a hydroxy group on the fourth carbon atom. It is an anabolic steroid with no therapeutic indications, which is prohibited from use in sports by...
ClostebolNot Available
AndrostenediolAndrostenediol is an intermediate in testosterone biosynthesis, found in the testis or the adrenal glands. Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), is converted...
AndrostenedioneA delta-4 C19 steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. Depending on the tissue type, androstenedione can serve as...
BoldenoneBoldenone is an anabolic steroid developed for veterinary use, mostly for treatment of horses. It is not indicated for use in humans in the US and is only available through...
CalusteroneAn anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was...
FormeboloneNo approved indications. Studied experimentally as a treatment for non-pituitary growth retardation.
PrasteroneA steroid formulated as a vaginal insert indicated for the treatment of moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy.
AfimoxifeneFor the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring.
HE3286For the treatment of rheumatoid arthritis and type 2 diabetes.
Prasterone sulfateInvestigated for use/treatment in asthma and burns and burn infections.
AbirateroneAn antiandrogen used in the treatment of prostate cancer.
FluasteroneInvestigated for use/treatment in psoriasis and psoriatic disorders, hyperlipidemia, metabolic disease, cancer/tumors (unspecified), and obesity.
MethyltestosteroneA synthetic anabolic steroid used for the replacement therapy in conditions associated with testosterone deficiencies in males, such as hypogonadism, and treatment of advancing inoperable metastatic breast cancer in females.
BoldioneNot Available
Testosterone succinateNot Available
FormestaneFor the treatment of estrogen-receptor positive breast cancer in post-menopausal women.
Fluticasone furoateAn inhaled corticosteroid that can be used as maintenance treatment of asthma and/or chronic obstructive pulmonary disease (COPD) depending on the product. Also available as a nasal spray to manage symptoms of allergic rhinitis.
AtamestaneAtamestane has been used in trials studying the treatment of Breast Cancer, Breast Neoplasms, and Neoplasms, Hormone-Dependent.
GaleteroneGaleterone has been used in trials studying the treatment of Prostate Cancer.
QuinboloneNot Annotated
MetandienoneNot Annotated
MetenoloneNot Annotated
FluticasoneFluticasone's 2 esters are indicated as inhalers for the treatment and management of asthma by prophylaxis[FDA Label] as well as inflammatory and pruritic dermatoses . A DB00588 nasal spray is...
Testosterone cypionateAn androgen used to treat low or absent testosterone.
Testosterone enanthateAn androgen used to treat low or absent testosterone.
Testosterone undecanoateAn androgen used to treat low or absent testosterone.
Testosterone enantate benzilic acid hydrazoneNot Annotated
WortmanninWortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks).
LoteprednolNot Annotated
Boldenone undecylenateNot Annotated
HE-2200Investigated for use/treatment in adverse effects (chemotherapy), hyperlipidemia, autoimmune diseases, and hepatitis (viral, B).
EpitestosteroneEpitestosterone is the 17-alpha isomer of testosterone, derived from pregnenolone via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone...
Drugs & Drug Targets
DrugTargetType
Fluticasone propionateCorticosteroid-binding globulincarrier
Fluticasone propionateCytosolic phospholipase A2target
Fluticasone propionateGlucocorticoid receptortarget
Fluticasone propionateCytochrome P450 3A4enzyme
Fluticasone propionateProgesterone receptortarget
Fluticasone propionateMineralocorticoid receptortarget
Fluticasone propionateCytochrome P450 3A5enzyme
Fluticasone propionateCytochrome P450 3A7enzyme
Fluticasone propionateCytochrome P450 2C8enzyme
Fluticasone propionateSolute carrier organic anion transporter family member 1B1carrier
Fluticasone propionateP-glycoprotein 1transporter
Fluticasone propionateSolute carrier organic anion transporter family member 1B1transporter
TestosteroneAndrogen receptortarget
TestosteroneCytochrome P450 3A4enzyme
TestosteroneCytochrome P450 19A1enzyme
TestosteroneAmine oxidase [flavin-containing] Aenzyme
TestosteroneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
TestosteroneSerum albumincarrier
TestosteroneSex hormone-binding globulincarrier
TestosteroneCytochrome P450 3A5enzyme
TestosteroneCytochrome P450 3A7enzyme
TestosteroneSolute carrier family 22 member 8transporter
TestosteroneSolute carrier family 22 member 7transporter
TestosteroneSodium/bile acid cotransportertransporter
TestosteroneATP-binding cassette sub-family G member 2transporter
TestosteroneCytochrome P450 1A1enzyme
TestosteroneCytochrome P450 1B1enzyme
TestosteroneCytochrome P450 2A13enzyme
TestosteroneCytochrome P450 2B6enzyme
TestosteroneCytochrome P450 2C19enzyme
TestosteroneCytochrome P450 2C8enzyme
TestosteroneCytochrome P450 2C9enzyme
TestosteroneCytochrome P450 3A43enzyme
TestosteroneEstrogen receptor alphatarget
TestosteroneMineralocorticoid receptortarget
TestosteroneSolute carrier organic anion transporter family member 1B3transporter
Loteprednol etabonateGlucocorticoid receptortarget
Loteprednol etabonateCytochrome P450 3A4enzyme
Loteprednol etabonateSerum paraoxonase/arylesterase 1enzyme
TestolactoneCytochrome P450 19A1target
ExemestaneCytochrome P450 19A1target
ExemestaneCytochrome P450 3A4enzyme
ExemestaneCytochrome P450 19A1enzyme
FluoxymesteroneSex hormone-binding globulincarrier
FluoxymesteroneEstrogen receptor alphatarget
FluoxymesteroneAndrogen receptortarget
FluoxymesteroneGlucocorticoid receptortarget
FluoxymesteroneCorticosteroid 11-beta-dehydrogenase isozyme 2target
Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1target
FinasterideCytochrome P450 3A4enzyme
Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 2target
Finasteride3-oxo-5-beta-steroid 4-dehydrogenasetarget
FinasterideCytochrome P450 3A5enzyme
FinasterideCytochrome P450 3A7enzyme
FinasterideSolute carrier family 12 member 5transporter
Testosterone propionateAndrogen receptortarget
Testosterone propionateCatechol O-methyltransferaseenzyme
Testosterone propionateUDP-glucuronosyltransferase 1-1enzyme
Testosterone propionate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone propionateCytochrome P450 3A4enzyme
Testosterone propionateP-glycoprotein 1transporter
Testosterone propionateSex hormone-binding globulincarrier
Testosterone propionateSerum albumincarrier
5-androstenedioneCytochrome P450 3A4enzyme
1-TestosteroneAndrogen receptortarget
AndrostenedioneAldo-keto reductase family 1 member C3target
AndrostenedioneEstradiol 17-beta-dehydrogenase 1target
Androstenedione6-deoxyerythronolide B hydroxylasetarget
Androstenedione3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
AndrostenedioneCytochrome P450 3A4enzyme
BoldenoneAndrogen receptortarget
CalusteroneAndrogen receptortarget
FormeboloneCorticosteroid 11-beta-dehydrogenase isozyme 2target
PrasteroneCytochrome P450 3A7enzyme
PrasteronePeroxisome proliferator-activated receptor alphatarget
PrasteroneEstrogen receptor alphatarget
PrasteroneSigma non-opioid intracellular receptor 1target
PrasteroneEstrogen receptor betatarget
PrasteroneNuclear receptor subfamily 1 group I member 2target
PrasteroneNuclear receptor subfamily 1 group I member 3target
PrasteroneGABA(A) Receptortarget
PrasteroneNMDA receptortarget
PrasteroneAndrogen receptortarget
PrasteroneEstradiol 17-beta-dehydrogenase 1enzyme
PrasteroneBile salt sulfotransferaseenzyme
PrasteroneSulfotransferase family cytosolic 2B member 1enzyme
Prasterone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1enzyme
PrasteroneCholesterol oxidaseenzyme
PrasteroneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
PrasteroneSolute carrier organic anion transporter family member 1B3transporter
PrasteroneSolute carrier organic anion transporter family member 2B1transporter
PrasteroneSolute carrier organic anion transporter family member 1B1transporter
PrasteroneSolute carrier organic anion transporter family member 1A2transporter
PrasteroneMultidrug resistance-associated protein 1transporter
PrasteroneATP-binding cassette sub-family G member 2transporter
PrasteroneMultidrug resistance-associated protein 4transporter
AfimoxifeneEstrogen receptor alphatarget
AfimoxifeneEstrogen receptor betatarget
AfimoxifeneEstrogen-related receptor gammatarget
AfimoxifeneTrefoil factor 1target
AfimoxifeneSteroid hormone receptor ERR1target
AfimoxifeneNuclear receptor subfamily 1 group I member 2target
AfimoxifeneSex hormone-binding globulintarget
HE3286Nuclear factor NF-kappa-B p105 subunittarget
HE3286Nuclear factor NF-kappa-B p100 subunittarget
HE3286Cytochrome P450 3A4enzyme
Prasterone sulfateCytochrome P450 19A1enzyme
Prasterone sulfateCytochrome P450 3A7enzyme
Prasterone sulfateProstaglandin G/H synthase 2enzyme
Prasterone sulfateSolute carrier family 22 member 8transporter
Prasterone sulfateSolute carrier organic anion transporter family member 1A2transporter
Prasterone sulfateSolute carrier organic anion transporter family member 1B1transporter
Prasterone sulfateSolute carrier organic anion transporter family member 1B3transporter
Prasterone sulfateSolute carrier organic anion transporter family member 2B1transporter
Prasterone sulfateSolute carrier family 10 member 6transporter
Prasterone sulfateBile salt export pumptransporter
AbirateroneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
AbirateroneSerum albumincarrier
AbirateroneAlpha-1-acid glycoprotein 1carrier
AbirateroneCytochrome P450 3A4enzyme
AbirateroneBile salt sulfotransferaseenzyme
AbirateroneMultidrug resistance-associated protein 1transporter
AbirateroneCytochrome P450 2D6enzyme
AbirateroneCytochrome P450 2C8enzyme
AbirateroneCytochrome P450 1A2enzyme
AbirateroneCytochrome P450 2C19enzyme
AbirateroneCytochrome P450 2C9enzyme
MethyltestosteroneCytochrome P450 2B6enzyme
MethyltestosteroneCytochrome P450 3A4enzyme
MethyltestosteroneAndrogen receptortarget
MethyltestosteroneSolute carrier organic anion transporter family member 1A2transporter
MethyltestosteroneSolute carrier family 22 member 8transporter
MethyltestosteroneSerum albumincarrier
MethyltestosteroneSex hormone-binding globulincarrier
MethyltestosteroneEstrogen receptor alphatarget
MethyltestosteroneCytochrome P450 19A1enzyme
BoldionePentaerythritol tetranitrate reductasetarget
Testosterone succinateNeocarzinostatintarget
FormestaneCytochrome P450 3A4enzyme
Fluticasone furoateCytochrome P450 3A4enzyme
Fluticasone furoateGlucocorticoid receptortarget
Fluticasone furoateP-glycoprotein 1transporter
Fluticasone furoateCytochrome P450 2C8enzyme
Fluticasone furoateSolute carrier organic anion transporter family member 1B1transporter
Fluticasone furoateCorticosteroid-binding globulincarrier
Fluticasone furoateP-glycoprotein 1carrier
Fluticasone furoateSolute carrier organic anion transporter family member 1B1carrier
Fluticasone furoateCytochrome P450 3A5enzyme
Fluticasone furoateCytochrome P450 3A7enzyme
Fluticasone furoateProgesterone receptortarget
Fluticasone furoateMineralocorticoid receptortarget
FluticasoneCytochrome P450 3A4enzyme
FluticasoneCytochrome P450 2C8enzyme
FluticasoneP-glycoprotein 1carrier
FluticasoneSolute carrier organic anion transporter family member 1B1carrier
FluticasoneP-glycoprotein 1transporter
FluticasoneSolute carrier organic anion transporter family member 1B1transporter
FluticasoneGlucocorticoid receptortarget
FluticasoneCorticosteroid-binding globulincarrier
FluticasoneCytochrome P450 3A5enzyme
FluticasoneCytochrome P450 3A7enzyme
FluticasoneProgesterone receptortarget
FluticasoneCytosolic phospholipase A2target
FluticasoneMineralocorticoid receptortarget
Testosterone cypionateAndrogen receptortarget
Testosterone cypionateCytochrome P450 3A4enzyme
Testosterone cypionateAmine oxidase [flavin-containing] Aenzyme
Testosterone cypionateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
Testosterone cypionateSerum albumincarrier
Testosterone cypionateSex hormone-binding globulincarrier
Testosterone cypionateCytochrome P450 3A5enzyme
Testosterone cypionateCytochrome P450 3A7enzyme
Testosterone cypionateSolute carrier organic anion transporter family member 1A2transporter
Testosterone cypionateSolute carrier family 22 member 8transporter
Testosterone cypionateSolute carrier family 22 member 7transporter
Testosterone cypionateP-glycoprotein 1transporter
Testosterone cypionateSodium/bile acid cotransportertransporter
Testosterone cypionateSolute carrier family 22 member 3transporter
Testosterone cypionateSolute carrier family 22 member 4transporter
Testosterone cypionateATP-binding cassette sub-family G member 2transporter
Testosterone cypionateCytochrome P450 1A1enzyme
Testosterone cypionateCytochrome P450 2A13enzyme
Testosterone cypionateCytochrome P450 2B6enzyme
Testosterone cypionateCytochrome P450 2C19enzyme
Testosterone cypionateCytochrome P450 2C8enzyme
Testosterone cypionateCytochrome P450 2C9enzyme
Testosterone cypionateCytochrome P450 3A43enzyme
Testosterone cypionateEstrogen receptor alphatarget
Testosterone cypionateMineralocorticoid receptortarget
Testosterone cypionate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone cypionateCytochrome P450 19A1enzyme
Testosterone enanthateAndrogen receptortarget
Testosterone enanthateCytochrome P450 3A4enzyme
Testosterone enanthateAmine oxidase [flavin-containing] Aenzyme
Testosterone enanthateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
Testosterone enanthateSerum albumincarrier
Testosterone enanthateSex hormone-binding globulincarrier
Testosterone enanthateCytochrome P450 3A5enzyme
Testosterone enanthateCytochrome P450 3A7enzyme
Testosterone enanthateSolute carrier organic anion transporter family member 1A2transporter
Testosterone enanthateSolute carrier family 22 member 8transporter
Testosterone enanthateSolute carrier family 22 member 7transporter
Testosterone enanthateP-glycoprotein 1transporter
Testosterone enanthateSodium/bile acid cotransportertransporter
Testosterone enanthateSolute carrier family 22 member 3transporter
Testosterone enanthateSolute carrier family 22 member 4transporter
Testosterone enanthateATP-binding cassette sub-family G member 2transporter
Testosterone enanthateCytochrome P450 1A1enzyme
Testosterone enanthateCytochrome P450 2A13enzyme
Testosterone enanthateCytochrome P450 2B6enzyme
Testosterone enanthateCytochrome P450 2C19enzyme
Testosterone enanthateCytochrome P450 2C8enzyme
Testosterone enanthateCytochrome P450 2C9enzyme
Testosterone enanthateCytochrome P450 3A43enzyme
Testosterone enanthateEstrogen receptor alphatarget
Testosterone enanthateMineralocorticoid receptortarget
Testosterone enanthate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone enanthateCytochrome P450 19A1enzyme
Testosterone undecanoateAndrogen receptortarget
Testosterone undecanoateCytochrome P450 3A4enzyme
Testosterone undecanoateAmine oxidase [flavin-containing] Aenzyme
Testosterone undecanoateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
Testosterone undecanoateSerum albumincarrier
Testosterone undecanoateSex hormone-binding globulincarrier
Testosterone undecanoateCytochrome P450 3A5enzyme
Testosterone undecanoateCytochrome P450 3A7enzyme
Testosterone undecanoateSolute carrier organic anion transporter family member 1A2transporter
Testosterone undecanoateSolute carrier family 22 member 8transporter
Testosterone undecanoateSolute carrier family 22 member 7transporter
Testosterone undecanoateP-glycoprotein 1transporter
Testosterone undecanoateSodium/bile acid cotransportertransporter
Testosterone undecanoateSolute carrier family 22 member 4transporter
Testosterone undecanoateATP-binding cassette sub-family G member 2transporter
Testosterone undecanoateCytochrome P450 1A1enzyme
Testosterone undecanoateCytochrome P450 1B1enzyme
Testosterone undecanoateCytochrome P450 2A13enzyme
Testosterone undecanoateCytochrome P450 2B6enzyme
Testosterone undecanoateCytochrome P450 2C19enzyme
Testosterone undecanoateCytochrome P450 2C8enzyme
Testosterone undecanoateCytochrome P450 2C9enzyme
Testosterone undecanoateCytochrome P450 3A43enzyme
Testosterone undecanoateEstrogen receptor alphatarget
Testosterone undecanoateMineralocorticoid receptortarget
Testosterone undecanoate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone undecanoateSolute carrier family 22 member 2transporter
Testosterone undecanoateMultidrug and toxin extrusion protein 1transporter
Testosterone undecanoateSolute carrier organic anion transporter family member 1B3transporter
Testosterone undecanoateCytochrome P450 19A1enzyme
WortmanninPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
WortmanninSerine/threonine-protein kinase PLK1target
WortmanninPhosphatidylinositol 3-kinase regulatory subunit alphatarget
WortmanninPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
Boldenone undecylenateAndrogen receptortarget
EpitestosteroneAldo-keto reductase family 1 member C1target
EpitestosteroneAldo-keto reductase family 1 member C2target