Identification
NameLumacaftor
Accession NumberDB09280
TypeSmall Molecule
GroupsApproved
Description

Lumacaftor is an experimental drug for the treatment of cystic fibrosis developed by Vertex Pharmaceuticals. The drug is designed to be effective in patients that have the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR), the defective protein that causes the disease. F508del, meaning that the amino acid phenylalanine in position 508 is missing, is found in about 60% of cystic fibrosis patients in Europe, and in about 90% of persons with some mutation in the CFTR gene.

Structure
Thumb
Synonyms
3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic acid
lumacaftor
External IDs VRT 826809 / VRT-826809 / VX 809 / VX-809
Product Ingredients Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
OrkambiVertex Pharmaceuticals Incorporated
Categories
UNIIEGP8L81APK
CAS number936727-05-8
WeightAverage: 452.414
Monoisotopic: 452.118378014
Chemical FormulaC24H18F2N2O5
InChI KeyUFSKUSARDNFIRC-UHFFFAOYSA-N
InChI
InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)
IUPAC Name
3-{6-[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropaneamido]-3-methylpyridin-2-yl}benzoic acid
SMILES
CC1=CC=C(NC(=O)C2(CC2)C2=CC=C3OC(F)(F)OC3=C2)N=C1C1=CC(=CC=C1)C(O)=O
Pharmacology
Indication

Cystic fibrosis is a disease that is caused by dysfunction of the 'cystic fibrosis transmembrane conductance regulator protein' (CFTR). As a result, cystic fibrosis affects many systems and involves progressive lung disease. Lumacaftor is an effective treatment for cystic fibrosis because it helps correct CFTR as well as the associated functions. (1)

Structured Indications
Pharmacodynamics

A double blind, placebo-controlled, Phase 2 clinical trial in select patients with cystic fibrosis demonstrated that lumacaftor 400 mg q12h alone reduced sweat chloride when compared to placebo. The mean change in sweat chloride from baseline to Day 28 was -8.2 mmol/L (95% CI -14, -2). (2)
The effect of lumacaftor in combination with ivacaftor on QTc interval prolongation was also studied, and there does not appear to be a meaningful correlation. (2)

Mechanism of action

The CFTR protein is a chloride channel and is found on the surface of epithelial cells in many tissues and organs. Cystic fibrosis involves an F508del mutation which results in a lower amount of properly processed chloride channels and also less which are successfully trafficked to cellular surfaces. Furthermore, the mutated CFTR that are able to reach cell surfaces will not function optimally. Lumacaftor helps stabilize F508del-CFTR, allowing more processing and trafficking to occur which increases the amount of mature protein that will reach cell surfaces. (2)

TargetKindPharmacological actionActionsOrganismUniProt ID
Cystic fibrosis transmembrane conductance regulatorProteinunknown
modulator
HumanP13569 details
Related Articles
Absorption

Lumacaftor taken with fat-containing foods is absorbed 3 time higher when compared to the drug taken in a fasting state. When repeated doses of lumacaftor combined with ivacaftor are administered, increases in dose of lumacaftor are generally correlated to increases in exposure over a range of 200 mg every 24 hours to 400 mg every 12 hours. (2)

Volume of distribution

Following oral administration of 200 mg of lumacaftor every 24 hours to cystic fibrosis patients in a fed state for 28 days, the mean (+/-SD) for apparent volumes of distribution was 86.0 (69.8) L. (2)

Protein binding

Lumacaftor is extensively protein bound in the plasma (99%), and binds primarily to albumin. (2)

Metabolism

Lumacaftor is mostly excreted unchanged in the feces and is not extensively metabolized. When metabolism does occur, oxidation and glucuronidation are the main processes involved. (2)

Route of elimination

Lumacaftor is primarily excreted unchanged in the feces (51%). A minimal amount of the parent compound and its metabolites are excreted in the urine. (2)

Half life

T1/2 = approximately 26 hours in patients who have cystic fibrosis (2)

ClearanceNot Available
Toxicity

Dyspnea, nasopharyngitis, nausea, diarrhea, upper respiratory tract infection, fatigue, respiration abnormal, blood creatine phosphokinase increased, rash, flatulence, rhinorrhea, and influenza are the most common adverse effects reported with the use of ORKAMBI. These adverse effects occurred in ≥5% of patients with cystic fibrosis homozygous for the F508del mutation in the CFTR gene. Lumacaftor is classified as Pregnancy Category B. (2)

Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Lumacaftor.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with Lumacaftor.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with Lumacaftor.Experimental, Illicit
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Lumacaftor.Approved
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Lumacaftor.Approved
AceclofenacThe serum concentration of Aceclofenac can be decreased when it is combined with Lumacaftor.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be decreased when it is combined with Lumacaftor.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Lumacaftor.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Lumacaftor.Approved, Vet Approved
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Lumacaftor.Approved
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Lumacaftor.Approved
AlbendazoleThe metabolism of Albendazole can be increased when combined with Lumacaftor.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be increased when combined with Lumacaftor.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Lumacaftor.Experimental
AlfentanilThe metabolism of Alfentanil can be increased when combined with Lumacaftor.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Lumacaftor.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be increased when combined with Lumacaftor.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Lumacaftor.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Lumacaftor.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Lumacaftor.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be increased when combined with Lumacaftor.Approved
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Lumacaftor.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Lumacaftor.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Lumacaftor.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be increased when combined with Lumacaftor.Approved
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Lumacaftor.Approved
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Lumacaftor.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be increased when combined with Lumacaftor.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Lumacaftor.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Lumacaftor.Approved
AmlodipineThe metabolism of Amlodipine can be increased when combined with Lumacaftor.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Lumacaftor.Approved
AmoxicillinThe serum concentration of Amoxicillin can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Lumacaftor.Approved
AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Lumacaftor.Experimental, Illicit
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Lumacaftor.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Lumacaftor.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Lumacaftor.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Lumacaftor.Approved, Investigational
Arachidonic AcidThe serum concentration of Arachidonic Acid can be decreased when it is combined with Lumacaftor.Experimental
ArformoterolThe serum concentration of Arformoterol can be decreased when it is combined with Lumacaftor.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be increased when combined with Lumacaftor.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Lumacaftor.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Lumacaftor.Approved, Investigational
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Lumacaftor resulting in a loss in efficacy.Approved
AsenapineThe metabolism of Asenapine can be increased when combined with Lumacaftor.Approved
AstemizoleThe metabolism of Astemizole can be increased when combined with Lumacaftor.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Lumacaftor.Approved, Investigational
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Lumacaftor.Approved
AtomoxetineThe serum concentration of Atomoxetine can be decreased when it is combined with Lumacaftor.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Lumacaftor.Approved
AvanafilThe metabolism of Avanafil can be increased when combined with Lumacaftor.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Lumacaftor.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Lumacaftor.Approved
AzithromycinThe metabolism of Azithromycin can be increased when combined with Lumacaftor.Approved
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Lumacaftor.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Lumacaftor.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Lumacaftor.Approved
BenzatropineThe serum concentration of Benzatropine can be decreased when it is combined with Lumacaftor.Approved
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Lumacaftor.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Lumacaftor.Approved
BeraprostThe serum concentration of Beraprost can be increased when it is combined with Lumacaftor.Investigational
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
BexaroteneThe serum concentration of Bexarotene can be decreased when it is combined with Lumacaftor.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Lumacaftor.Approved
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Lumacaftor.Approved
BisoprololThe metabolism of Bisoprolol can be increased when combined with Lumacaftor.Approved
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Lumacaftor.Approved, Investigational
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Lumacaftor.Approved, Investigational
BosentanThe serum concentration of Bosentan can be decreased when it is combined with Lumacaftor.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Lumacaftor.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Lumacaftor.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Lumacaftor.Approved
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Lumacaftor.Approved
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Lumacaftor.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Lumacaftor.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Lumacaftor.Approved
BudesonideThe metabolism of Budesonide can be increased when combined with Lumacaftor.Approved
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Lumacaftor.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Lumacaftor.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Lumacaftor.Approved
BuspironeThe metabolism of Buspirone can be increased when combined with Lumacaftor.Approved, Investigational
BusulfanThe metabolism of Busulfan can be increased when combined with Lumacaftor.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Lumacaftor.Approved
CabergolineThe metabolism of Cabergoline can be increased when combined with Lumacaftor.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Lumacaftor.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Lumacaftor.Approved
CalcitriolThe metabolism of Calcitriol can be increased when combined with Lumacaftor.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Lumacaftor.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Lumacaftor.Approved
CandesartanThe serum concentration of Candesartan can be decreased when it is combined with Lumacaftor.Approved
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Lumacaftor.Approved, Investigational
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Lumacaftor.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Lumacaftor.Approved
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Lumacaftor.Approved
CariprazineThe metabolism of Cariprazine can be increased when combined with Lumacaftor.Approved
CarisoprodolThe serum concentration of Carisoprodol can be decreased when it is combined with Lumacaftor.Approved
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Lumacaftor.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Lumacaftor.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be increased when combined with Lumacaftor.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be increased when combined with Lumacaftor.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Lumacaftor.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Lumacaftor.Withdrawn
CevimelineThe metabolism of Cevimeline can be increased when combined with Lumacaftor.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Lumacaftor.Approved
ChloramphenicolThe serum concentration of Chloramphenicol can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Lumacaftor.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Lumacaftor.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Lumacaftor.Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Lumacaftor.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
ChlorpropamideThe serum concentration of Chlorpropamide can be decreased when it is combined with Lumacaftor.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Lumacaftor.Approved
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Lumacaftor.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be increased when combined with Lumacaftor.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with Lumacaftor.Approved
CimetidineThe serum concentration of Cimetidine can be decreased when it is combined with Lumacaftor.Approved
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Lumacaftor.Approved
CinnarizineThe serum concentration of Cinnarizine can be decreased when it is combined with Lumacaftor.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Lumacaftor.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Lumacaftor.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Lumacaftor.Approved
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Lumacaftor.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Lumacaftor.Approved
ClindamycinThe metabolism of Clindamycin can be increased when combined with Lumacaftor.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Lumacaftor.Approved, Illicit
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Lumacaftor.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Lumacaftor.Approved
ClofazimineThe metabolism of Clofazimine can be increased when combined with Lumacaftor.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be increased when combined with Lumacaftor.Approved
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Lumacaftor.Approved, Investigational
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be increased when combined with Lumacaftor.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Lumacaftor.Approved
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Lumacaftor.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be increased when combined with Lumacaftor.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Lumacaftor.Approved, Illicit
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Lumacaftor.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Lumacaftor.Approved
CocaineThe metabolism of Cocaine can be increased when combined with Lumacaftor.Approved, Illicit
CodeineThe metabolism of Codeine can be increased when combined with Lumacaftor.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Lumacaftor.Approved
ConivaptanThe metabolism of Conivaptan can be increased when combined with Lumacaftor.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Lumacaftor.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be increased when combined with Lumacaftor.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Lumacaftor.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with Lumacaftor.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Lumacaftor.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be increased when combined with Lumacaftor.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Lumacaftor.Approved
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Lumacaftor.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Lumacaftor.Approved
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Lumacaftor.Approved
DantroleneThe metabolism of Dantrolene can be increased when combined with Lumacaftor.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Lumacaftor.Approved
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Lumacaftor.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be increased when combined with Lumacaftor.Approved, Investigational
DarunavirThe metabolism of Darunavir can be increased when combined with Lumacaftor.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Lumacaftor.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Lumacaftor.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Lumacaftor.Approved
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Lumacaftor.Approved
DelavirdineThe metabolism of Delavirdine can be increased when combined with Lumacaftor.Approved
DesipramineThe serum concentration of Desipramine can be decreased when it is combined with Lumacaftor.Approved
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Lumacaftor.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Lumacaftor.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Lumacaftor.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Lumacaftor.Approved
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Lumacaftor.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Lumacaftor.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Lumacaftor.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Lumacaftor.Approved, Vet Approved
DicoumarolThe serum concentration of Dicoumarol can be decreased when it is combined with Lumacaftor.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Lumacaftor.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Lumacaftor.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Lumacaftor.Approved
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Lumacaftor.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Lumacaftor.Approved
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Lumacaftor.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Lumacaftor.Approved
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Lumacaftor.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Lumacaftor.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Lumacaftor.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Lumacaftor.Illicit
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Lumacaftor.Approved
DiphenhydramineThe serum concentration of Diphenhydramine can be decreased when it is combined with Lumacaftor.Approved
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Lumacaftor.Approved
DisopyramideThe metabolism of Disopyramide can be increased when combined with Lumacaftor.Approved
DisulfiramThe metabolism of Disulfiram can be increased when combined with Lumacaftor.Approved
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Lumacaftor.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be increased when combined with Lumacaftor.Approved
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Lumacaftor.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Lumacaftor.Approved
DopamineThe serum concentration of Dopamine can be decreased when it is combined with Lumacaftor.Approved
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Lumacaftor.Approved
DoxazosinThe serum concentration of Doxazosin can be decreased when it is combined with Lumacaftor.Approved
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Lumacaftor.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Lumacaftor.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Lumacaftor.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Lumacaftor.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Lumacaftor.Approved
DutasterideThe metabolism of Dutasteride can be increased when combined with Lumacaftor.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Lumacaftor.Approved
EfavirenzThe serum concentration of Efavirenz can be decreased when it is combined with Lumacaftor.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Lumacaftor.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Lumacaftor.Approved
EltrombopagThe serum concentration of Eltrombopag can be increased when it is combined with Lumacaftor.Approved
ElvitegravirThe metabolism of Elvitegravir can be increased when combined with Lumacaftor.Approved
EnalaprilThe metabolism of Enalapril can be increased when combined with Lumacaftor.Approved, Vet Approved
EnfuvirtideThe serum concentration of Enfuvirtide can be decreased when it is combined with Lumacaftor.Approved, Investigational
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Lumacaftor.Approved
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Lumacaftor.Approved, Investigational
EplerenoneThe metabolism of Eplerenone can be increased when combined with Lumacaftor.Approved
EpoprostenolThe serum concentration of Epoprostenol can be decreased when it is combined with Lumacaftor.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Lumacaftor.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with Lumacaftor.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Lumacaftor.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Lumacaftor.Approved
ErgonovineThe metabolism of Ergonovine can be increased when combined with Lumacaftor.Approved
ErgotamineThe metabolism of Ergotamine can be increased when combined with Lumacaftor.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Lumacaftor.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Lumacaftor.Approved, Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Lumacaftor.Approved, Investigational
EstazolamThe metabolism of Estazolam can be increased when combined with Lumacaftor.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Lumacaftor.Approved
EstriolThe serum concentration of Estriol can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Lumacaftor.Approved
EstroneThe serum concentration of Estrone can be decreased when it is combined with Lumacaftor.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Lumacaftor.Approved
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Lumacaftor.Approved
EthanolThe metabolism of Ethanol can be increased when combined with Lumacaftor.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Lumacaftor.Approved
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Lumacaftor.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Lumacaftor.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Lumacaftor.Approved
EtodolacThe serum concentration of Etodolac can be decreased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Lumacaftor.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Lumacaftor.Approved
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Lumacaftor.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Lumacaftor.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Lumacaftor.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Lumacaftor.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Lumacaftor.Approved
FamciclovirThe metabolism of Famciclovir can be increased when combined with Lumacaftor.Approved
FamotidineThe serum concentration of Famotidine can be decreased when it is combined with Lumacaftor.Approved
FelbamateThe metabolism of Felbamate can be increased when combined with Lumacaftor.Approved
FelodipineThe metabolism of Felodipine can be increased when combined with Lumacaftor.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Lumacaftor.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Lumacaftor.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Lumacaftor.Approved
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Lumacaftor.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Lumacaftor.Approved
FinasterideThe metabolism of Finasteride can be increased when combined with Lumacaftor.Approved
FingolimodThe metabolism of Fingolimod can be increased when combined with Lumacaftor.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Lumacaftor.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Lumacaftor.Approved
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
FlunarizineThe serum concentration of Flunarizine can be decreased when it is combined with Lumacaftor.Approved
FlunisolideThe metabolism of Flunisolide can be increased when combined with Lumacaftor.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Lumacaftor.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Lumacaftor.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Lumacaftor.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be increased when combined with Lumacaftor.Approved
FluorouracilThe serum concentration of Fluorouracil can be increased when it is combined with Lumacaftor.Approved
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Lumacaftor.Approved, Withdrawn
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Lumacaftor.Approved
FlurazepamThe metabolism of Flurazepam can be increased when combined with Lumacaftor.Approved, Illicit
FlurbiprofenThe serum concentration of Flurbiprofen can be decreased when it is combined with Lumacaftor.Approved, Investigational
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Lumacaftor.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Lumacaftor.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be increased when combined with Lumacaftor.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Lumacaftor.Approved
FormestaneThe serum concentration of Formestane can be decreased when it is combined with Lumacaftor.Approved, Investigational, Withdrawn
FormoterolThe serum concentration of Formoterol can be decreased when it is combined with Lumacaftor.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be increased when combined with Lumacaftor.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Lumacaftor.Approved
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Lumacaftor.Approved, Investigational
GalantamineThe metabolism of Galantamine can be increased when combined with Lumacaftor.Approved
GavestinelThe serum concentration of Gavestinel can be decreased when it is combined with Lumacaftor.Investigational
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Lumacaftor.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Lumacaftor.Approved
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Lumacaftor.Approved
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Lumacaftor.Approved
GliclazideThe serum concentration of Gliclazide can be decreased when it is combined with Lumacaftor.Approved
GlimepirideThe serum concentration of Glimepiride can be decreased when it is combined with Lumacaftor.Approved
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Lumacaftor.Approved
GlucosamineThe serum concentration of Glucosamine can be decreased when it is combined with Lumacaftor.Approved
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Lumacaftor.Approved
GranisetronThe metabolism of Granisetron can be increased when combined with Lumacaftor.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Lumacaftor.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Lumacaftor.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Lumacaftor.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Lumacaftor.Approved
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Lumacaftor.Approved
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with Lumacaftor.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Lumacaftor.Withdrawn
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Lumacaftor.Approved
HistamineThe serum concentration of Histamine Phosphate can be decreased when it is combined with Lumacaftor.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Lumacaftor.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Lumacaftor.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Lumacaftor.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Lumacaftor.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Lumacaftor.Approved
IdarubicinThe serum concentration of Idarubicin can be decreased when it is combined with Lumacaftor.Approved
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Lumacaftor.Approved
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Lumacaftor.Approved
IloperidoneThe metabolism of Iloperidone can be increased when combined with Lumacaftor.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Lumacaftor.Approved
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Lumacaftor.Approved
ImiquimodThe metabolism of Imiquimod can be increased when combined with Lumacaftor.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Lumacaftor.Approved
IndapamideThe metabolism of Indapamide can be increased when combined with Lumacaftor.Approved
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Lumacaftor.Approved
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Lumacaftor.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Lumacaftor.Approved
IrbesartanThe serum concentration of Irbesartan can be increased when it is combined with Lumacaftor.Approved, Investigational
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Lumacaftor resulting in a loss in efficacy.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Lumacaftor resulting in a loss in efficacy.Approved, Investigational
IsofluraneThe serum concentration of Isoflurane can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Lumacaftor.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Lumacaftor.Approved
IsradipineThe metabolism of Isradipine can be increased when combined with Lumacaftor.Approved
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Lumacaftor.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Lumacaftor.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Lumacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Lumacaftor.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Lumacaftor.Approved
KetamineThe serum concentration of Ketamine can be increased when it is combined with Lumacaftor.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Lumacaftor.Approved
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Lumacaftor.Approved
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Lumacaftor.Approved, Investigational
KetoprofenThe serum concentration of Ketoprofen can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Lumacaftor.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Lumacaftor.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Lumacaftor.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Lumacaftor.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be increased when combined with Lumacaftor.Investigational
LeflunomideThe serum concentration of Leflunomide can be decreased when it is combined with Lumacaftor.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Lumacaftor.Approved
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Lumacaftor.Approved
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Lumacaftor.Approved, Investigational
LesinuradThe serum concentration of Lesinurad can be decreased when it is combined with Lumacaftor.Approved
LetrozoleThe metabolism of Letrozole can be increased when combined with Lumacaftor.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Lumacaftor.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Lumacaftor.Approved
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Lumacaftor.Approved
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Lumacaftor.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Lumacaftor.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Lumacaftor.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Lumacaftor.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be increased when combined with Lumacaftor.Approved
LicofeloneThe serum concentration of Licofelone can be increased when it is combined with Lumacaftor.Investigational
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Lumacaftor.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Lumacaftor.Approved
LisurideThe metabolism of Lisuride can be increased when combined with Lumacaftor.Approved
LomitapideThe metabolism of Lomitapide can be increased when combined with Lumacaftor.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Lumacaftor.Approved
LopinavirThe metabolism of Lopinavir can be increased when combined with Lumacaftor.Approved
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Lumacaftor.Approved
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Lumacaftor.Approved
LornoxicamThe serum concentration of Lornoxicam can be decreased when it is combined with Lumacaftor.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Lumacaftor.Approved
LovastatinThe metabolism of Lovastatin can be increased when combined with Lumacaftor.Approved, Investigational
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Lumacaftor.Approved
LumiracoxibThe serum concentration of Lumiracoxib can be decreased when it is combined with Lumacaftor.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Lumacaftor.Approved
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Lumacaftor.Approved
MalathionThe serum concentration of Malathion can be decreased when it is combined with Lumacaftor.Approved, Investigational
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Lumacaftor.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Lumacaftor.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with Lumacaftor.Investigational
MebendazoleThe metabolism of Mebendazole can be increased when combined with Lumacaftor.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Lumacaftor.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Lumacaftor.Approved
Mefenamic acidThe serum concentration of Mefenamic acid can be increased when it is combined with Lumacaftor.Approved
MefloquineThe metabolism of Mefloquine can be increased when combined with Lumacaftor.Approved
MelatoninThe serum concentration of Melatonin can be decreased when it is combined with Lumacaftor.Approved, Nutraceutical, Vet Approved
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Lumacaftor.Approved, Vet Approved
MephenytoinThe serum concentration of Mephenytoin can be increased when it is combined with Lumacaftor.Investigational, Withdrawn
MeprobamateThe serum concentration of Meprobamate can be decreased when it is combined with Lumacaftor.Approved, Illicit
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Lumacaftor.Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Lumacaftor.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Lumacaftor.Experimental
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Lumacaftor.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Lumacaftor.Approved
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Lumacaftor.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
MethsuximideThe serum concentration of Methsuximide can be decreased when it is combined with Lumacaftor.Approved
MethylphenobarbitalThe serum concentration of Methylphenobarbital can be decreased when it is combined with Lumacaftor.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Lumacaftor.Approved
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with Lumacaftor.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Lumacaftor.Approved
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Lumacaftor.Approved
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Lumacaftor.Approved
MibefradilThe metabolism of Mibefradil can be increased when combined with Lumacaftor.Withdrawn
MiconazoleThe metabolism of Miconazole can be increased when combined with Lumacaftor.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Lumacaftor.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Lumacaftor.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Lumacaftor.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Lumacaftor.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Lumacaftor.Approved, Investigational
MoclobemideThe serum concentration of Moclobemide can be decreased when it is combined with Lumacaftor.Approved
ModafinilThe metabolism of Modafinil can be increased when combined with Lumacaftor.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Lumacaftor.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Lumacaftor.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Lumacaftor.Approved, Investigational
NadololThe serum concentration of Nadolol can be decreased when it is combined with Lumacaftor.Approved
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Lumacaftor.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Lumacaftor.Approved, Vet Approved
NaproxenThe serum concentration of Naproxen can be increased when it is combined with Lumacaftor.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Lumacaftor.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with Lumacaftor.Investigational
NefazodoneThe metabolism of Nefazodone can be increased when combined with Lumacaftor.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Lumacaftor.Approved
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Lumacaftor.Approved
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Lumacaftor.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Lumacaftor.Approved
NiclosamideThe serum concentration of Niclosamide can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
NicotineThe serum concentration of Nicotine can be increased when it is combined with Lumacaftor.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Lumacaftor.Approved
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Lumacaftor.Approved, Investigational
NilutamideThe serum concentration of Nilutamide can be decreased when it is combined with Lumacaftor.Approved
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Lumacaftor.Approved
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Lumacaftor.Approved
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Lumacaftor.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Lumacaftor.Approved
NitrazepamThe metabolism of Nitrazepam can be increased when combined with Lumacaftor.Approved
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Lumacaftor.Approved
NizatidineThe serum concentration of Nizatidine can be decreased when it is combined with Lumacaftor.Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Lumacaftor.Approved
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Lumacaftor.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Lumacaftor.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Lumacaftor.Approved
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Lumacaftor.Approved
OlanzapineThe serum concentration of Olanzapine can be decreased when it is combined with Lumacaftor.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Lumacaftor.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be decreased when it is combined with Lumacaftor.Investigational
OlodaterolThe serum concentration of Olodaterol can be increased when it is combined with Lumacaftor.Approved
OlopatadineThe metabolism of Olopatadine can be increased when combined with Lumacaftor.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Lumacaftor.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Lumacaftor.Approved
OrphenadrineThe metabolism of Orphenadrine can be increased when combined with Lumacaftor.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Lumacaftor.Approved
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Lumacaftor.Approved
OxaprozinThe serum concentration of Oxaprozin can be decreased when it is combined with Lumacaftor.Approved
OxazepamThe metabolism of Oxazepam can be increased when combined with Lumacaftor.Approved
OxiconazoleThe serum concentration of Oxiconazole can be decreased when it is combined with Lumacaftor.Approved
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Lumacaftor.Approved, Investigational
OxycodoneThe metabolism of Oxycodone can be increased when combined with Lumacaftor.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Lumacaftor.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Lumacaftor.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Lumacaftor.Approved
PalonosetronThe metabolism of Palonosetron can be increased when combined with Lumacaftor.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Lumacaftor.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Lumacaftor.Approved
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Lumacaftor.Approved
ParamethasoneThe metabolism of Paramethasone can be increased when combined with Lumacaftor.Approved
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Lumacaftor.Approved
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Lumacaftor.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be increased when combined with Lumacaftor.Approved
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Lumacaftor.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Lumacaftor.Approved
PentobarbitalThe serum concentration of Pentobarbital can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Lumacaftor.Approved
PergolideThe metabolism of Pergolide can be increased when combined with Lumacaftor.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Lumacaftor.Approved
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Lumacaftor.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Lumacaftor.Approved
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Lumacaftor.Approved
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Lumacaftor.Withdrawn
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Lumacaftor.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Lumacaftor.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Lumacaftor.Approved
PhenylbutazoneThe serum concentration of Phenylbutazone can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Lumacaftor.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Lumacaftor.Approved
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Lumacaftor.Approved, Investigational
PimozideThe metabolism of Pimozide can be increased when combined with Lumacaftor.Approved
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Lumacaftor.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Lumacaftor.Approved
PiroxicamThe serum concentration of Piroxicam can be increased when it is combined with Lumacaftor.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Lumacaftor.Approved
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Lumacaftor.Approved
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Lumacaftor.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Lumacaftor.Approved
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be increased when combined with Lumacaftor.Approved, Nutraceutical
Prasterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Lumacaftor.Investigational
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Lumacaftor.Approved
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Lumacaftor.Approved
PrazepamThe metabolism of Prazepam can be increased when combined with Lumacaftor.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Lumacaftor.Approved
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Lumacaftor.Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Lumacaftor.Experimental
PrimaquineThe metabolism of Primaquine can be increased when combined with Lumacaftor.Approved
PrimidoneThe serum concentration of Primidone can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Lumacaftor.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Lumacaftor.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Lumacaftor.Approved
PromazineThe serum concentration of Promazine can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
PromethazineThe serum concentration of Promethazine can be decreased when it is combined with Lumacaftor.Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Lumacaftor.Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Lumacaftor.Approved, Investigational
PyrazinamideThe metabolism of Pyrazinamide can be increased when combined with Lumacaftor.Approved
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Lumacaftor.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Lumacaftor.Approved
QuinacrineThe metabolism of Quinacrine can be increased when combined with Lumacaftor.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Lumacaftor.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Lumacaftor.Approved
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Lumacaftor.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Lumacaftor.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Lumacaftor.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be decreased when it is combined with Lumacaftor.Approved
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Lumacaftor.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be increased when combined with Lumacaftor.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Lumacaftor.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Lumacaftor.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be decreased when it is combined with Lumacaftor.Approved
RetapamulinThe metabolism of Retapamulin can be increased when combined with Lumacaftor.Approved
RifabutinThe metabolism of Rifabutin can be increased when combined with Lumacaftor.Approved
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Lumacaftor.Approved
RilpivirineThe metabolism of Rilpivirine can be increased when combined with Lumacaftor.Approved
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Lumacaftor.Approved
RimonabantThe metabolism of Rimonabant can be increased when combined with Lumacaftor.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Lumacaftor.Approved
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Lumacaftor.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Lumacaftor.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Lumacaftor.Approved
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Lumacaftor.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Lumacaftor.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Lumacaftor.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Lumacaftor.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be increased when combined with Lumacaftor.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Lumacaftor.Approved
RosiglitazoneThe serum concentration of Rosiglitazone can be increased when it is combined with Lumacaftor.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Lumacaftor.Approved
RotigotineThe metabolism of Rotigotine can be increased when combined with Lumacaftor.Approved
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Lumacaftor.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Lumacaftor.Approved
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
SalmeterolThe metabolism of Salmeterol can be increased when combined with Lumacaftor.Approved
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Lumacaftor.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Lumacaftor.Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Lumacaftor.Approved
SertindoleThe metabolism of Sertindole can be increased when combined with Lumacaftor.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Lumacaftor.Approved
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be increased when combined with Lumacaftor.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Lumacaftor.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Lumacaftor.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Lumacaftor.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Lumacaftor.Approved
SirolimusThe metabolism of Sirolimus can be increased when combined with Lumacaftor.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Lumacaftor.Approved, Investigational
SitaxentanThe serum concentration of Sitaxentan can be decreased when it is combined with Lumacaftor.Approved, Investigational, Withdrawn
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Lumacaftor.Approved
SolifenacinThe metabolism of Solifenacin can be increased when combined with Lumacaftor.Approved
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Lumacaftor.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Lumacaftor.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Lumacaftor.Approved
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Lumacaftor.Experimental
SpiramycinThe metabolism of Spiramycin can be increased when combined with Lumacaftor.Approved
SufentanilThe metabolism of Sufentanil can be increased when combined with Lumacaftor.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Lumacaftor.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Lumacaftor.Approved
SulfamoxoleThe serum concentration of Sulfamoxole can be decreased when it is combined with Lumacaftor.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Lumacaftor.Approved
SulfisoxazoleThe serum concentration of Sulfisoxazole can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Lumacaftor.Approved, Investigational
SuprofenThe serum concentration of Suprofen can be decreased when it is combined with Lumacaftor.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Lumacaftor.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Lumacaftor.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Lumacaftor.Approved
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Lumacaftor.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Lumacaftor.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Lumacaftor.Approved
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Lumacaftor.Approved, Investigational
TapentadolThe serum concentration of Tapentadol can be decreased when it is combined with Lumacaftor.Approved
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Lumacaftor.Approved
TasosartanThe metabolism of Tasosartan can be increased when combined with Lumacaftor.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Lumacaftor.Experimental
TazaroteneThe serum concentration of Tazarotene can be increased when it is combined with Lumacaftor.Approved, Investigational
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Lumacaftor.Approved
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Lumacaftor.Withdrawn
TelithromycinThe metabolism of Telithromycin can be increased when combined with Lumacaftor.Approved
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Lumacaftor.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Lumacaftor.Approved
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Lumacaftor.Approved
TenoxicamThe serum concentration of Tenoxicam can be decreased when it is combined with Lumacaftor.Approved
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Lumacaftor.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Lumacaftor.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Lumacaftor.Investigational
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Lumacaftor.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be increased when combined with Lumacaftor.Approved, Vet Approved
ThalidomideThe serum concentration of Thalidomide can be decreased when it is combined with Lumacaftor.Approved, Investigational, Withdrawn
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Lumacaftor.Approved
ThiamylalThe serum concentration of Thiamylal can be decreased when it is combined with Lumacaftor.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be decreased when it is combined with Lumacaftor.Withdrawn
ThiotepaThe metabolism of Thiotepa can be increased when combined with Lumacaftor.Approved
TiagabineThe metabolism of Tiagabine can be increased when combined with Lumacaftor.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Lumacaftor resulting in a loss in efficacy.Approved
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Lumacaftor.Approved
TimololThe serum concentration of Timolol can be decreased when it is combined with Lumacaftor.Approved
TinidazoleThe metabolism of Tinidazole can be increased when combined with Lumacaftor.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be increased when combined with Lumacaftor.Approved
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Lumacaftor.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Lumacaftor.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Lumacaftor.Approved, Investigational
TolbutamideThe serum concentration of Tolbutamide can be increased when it is combined with Lumacaftor.Approved
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Lumacaftor.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Lumacaftor.Approved
TopotecanThe serum concentration of Topotecan can be decreased when it is combined with Lumacaftor.Approved, Investigational
TorasemideThe serum concentration of Torasemide can be increased when it is combined with Lumacaftor.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Lumacaftor.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Lumacaftor.Approved, Investigational
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Lumacaftor.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Lumacaftor.Approved
TrazodoneThe metabolism of Trazodone can be increased when combined with Lumacaftor.Approved, Investigational
TreprostinilThe serum concentration of Treprostinil can be decreased when it is combined with Lumacaftor.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Lumacaftor.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be increased when combined with Lumacaftor.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be increased when combined with Lumacaftor.Approved
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Lumacaftor.Approved
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Lumacaftor.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Lumacaftor.Approved
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Lumacaftor.Withdrawn
UdenafilThe metabolism of Udenafil can be increased when combined with Lumacaftor.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Lumacaftor.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Lumacaftor.Approved
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Lumacaftor.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Lumacaftor.Approved, Investigational
ValsartanThe serum concentration of Valsartan can be decreased when it is combined with Lumacaftor.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Lumacaftor.Approved
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Lumacaftor.Investigational
VardenafilThe metabolism of Vardenafil can be increased when combined with Lumacaftor.Approved
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Lumacaftor.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Lumacaftor.Approved
VenetoclaxThe serum concentration of Venetoclax can be decreased when it is combined with Lumacaftor.Approved
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Lumacaftor.Approved
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Lumacaftor.Approved
VilanterolThe metabolism of Vilanterol can be increased when combined with Lumacaftor.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Lumacaftor.Approved
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Lumacaftor.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Lumacaftor.Approved, Investigational
VindesineThe metabolism of Vindesine can be increased when combined with Lumacaftor.Approved
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Lumacaftor.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Lumacaftor.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Lumacaftor.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Lumacaftor.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Lumacaftor.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Lumacaftor.Approved
XimelagatranThe serum concentration of Ximelagatran can be decreased when it is combined with Lumacaftor.Approved, Investigational, Withdrawn
YohimbineThe metabolism of Yohimbine can be increased when combined with Lumacaftor.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Lumacaftor.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Lumacaftor.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Lumacaftor.Approved, Illicit, Investigational
ZaltoprofenThe serum concentration of Zaltoprofen can be decreased when it is combined with Lumacaftor.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Lumacaftor.Approved
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Lumacaftor.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Lumacaftor.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Lumacaftor.Approved
ZomepiracThe metabolism of Zomepirac can be increased when combined with Lumacaftor.Withdrawn
ZonisamideThe metabolism of Zonisamide can be increased when combined with Lumacaftor.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Lumacaftor.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Lumacaftor.Approved, Investigational
Food InteractionsNo interactions found.
References
Synthesis ReferenceNot Available
General References
  1. Boyle MP, Bell SC, Konstan MW, McColley SA, Rowe SM, Rietschel E, Huang X, Waltz D, Patel NR, Rodman D: A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial. Lancet Respir Med. 2014 Jul;2(7):527-38. doi: 10.1016/S2213-2600(14)70132-8. Epub 2014 Jun 24. [PubMed:24973281 ]
External Links
ATC CodesR07AX30
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (335 KB)
MSDSNot Available
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableCystic Fibrosis (CF)1
1CompletedTreatmentCystic Fibrosis (CF)4
2Active Not RecruitingTreatmentCystic Fibrosis (CF)1
2CompletedTreatmentCystic Fibrosis (CF)2
2RecruitingTreatmentCystic Fibrosis (CF)1
3CompletedTreatmentAdvanced Lung Disease / Cystic Fibrosis (CF)1
3CompletedTreatmentCystic Fibrosis (CF)2
3CompletedTreatmentCystic Fibrosis, Homozygous or Heterozygous for the F508del-CFTR Mutation1
3Enrolling by InvitationTreatmentCystic Fibrosis (CF)2
3RecruitingTreatmentCystic Fibrosis (CF)1
4Active Not RecruitingOtherCystic Fibrosis (CF)1
4RecruitingTreatmentCystic Fibrosis (CF)1
Not AvailableNot Yet RecruitingScreeningCystic Fibrosis (CF) / Diabetes2
Not AvailableRecruitingNot AvailableCystic Fibrosis (CF)1
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
TabletOral
Tablet, film coatedOral
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7495103 No2007-05-202027-05-20Us
US8324242 No2007-04-182027-04-18Us
US8410274 No2006-12-282026-12-28Us
US8507534 No2010-09-202030-09-20Us
US8653103 No2008-12-042028-12-04Us
US8716338 No2006-11-082026-11-08Us
US8741933 No2006-11-082026-11-08Us
US8754224 No2006-12-282026-12-28Us
US8846718 No2008-12-042028-12-04Us
US8993600 No2010-12-112030-12-11Us
US9216969 No2006-11-082026-11-08Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.00376 mg/mLALOGPS
logP4.37ALOGPS
logP5.77ChemAxon
logS-5.1ALOGPS
pKa (Strongest Acidic)4.17ChemAxon
pKa (Strongest Basic)3.5ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area97.75 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity111.97 m3·mol-1ChemAxon
Polarizability44.12 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET featuresNot Available
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassPhenylpyridines
Direct ParentPhenylpyridines
Alternative ParentsBenzodioxoles / Benzoic acids / Benzoyl derivatives / N-arylamides / Methylpyridines / Imidolactams / Cyclopropanecarboxylic acids and derivatives / Heteroaromatic compounds / Secondary carboxylic acid amides / Azacyclic compounds
Substituents2-phenylpyridine / Benzodioxole / Benzoic acid or derivatives / Benzoic acid / Benzoyl / N-arylamide / Methylpyridine / Monocyclic benzene moiety / Cyclopropanecarboxylic acid or derivatives / Benzenoid
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
modulator
General Function:
Pdz domain binding
Specific Function:
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Gene Name:
CFTR
Uniprot ID:
P13569
Molecular Weight:
168139.895 Da
References
  1. Kuk K, Taylor-Cousar JL: Lumacaftor and ivacaftor in the management of patients with cystic fibrosis: current evidence and future prospects. Ther Adv Respir Dis. 2015 Dec;9(6):313-26. doi: 10.1177/1753465815601934. Epub 2015 Sep 28. [PubMed:26416827 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Jordan CL, Noah TL, Henry MM: Therapeutic challenges posed by critical drug-drug interactions in cystic fibrosis. Pediatr Pulmonol. 2016 Oct;51(S44):S61-S70. doi: 10.1002/ppul.23505. [PubMed:27662106 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Kuk K, Taylor-Cousar JL: Lumacaftor and ivacaftor in the management of patients with cystic fibrosis: current evidence and future prospects. Ther Adv Respir Dis. 2015 Dec;9(6):313-26. doi: 10.1177/1753465815601934. Epub 2015 Sep 28. [PubMed:26416827 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Kuk K, Taylor-Cousar JL: Lumacaftor and ivacaftor in the management of patients with cystic fibrosis: current evidence and future prospects. Ther Adv Respir Dis. 2015 Dec;9(6):313-26. doi: 10.1177/1753465815601934. Epub 2015 Sep 28. [PubMed:26416827 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Kuk K, Taylor-Cousar JL: Lumacaftor and ivacaftor in the management of patients with cystic fibrosis: current evidence and future prospects. Ther Adv Respir Dis. 2015 Dec;9(6):313-26. doi: 10.1177/1753465815601934. Epub 2015 Sep 28. [PubMed:26416827 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Kuk K, Taylor-Cousar JL: Lumacaftor and ivacaftor in the management of patients with cystic fibrosis: current evidence and future prospects. Ther Adv Respir Dis. 2015 Dec;9(6):313-26. doi: 10.1177/1753465815601934. Epub 2015 Sep 28. [PubMed:26416827 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
Drug created on October 29, 2015 09:12 / Updated on June 24, 2017 13:31