Protease Inhibitors

Name
Protease Inhibitors
Accession Number
DBCAT000002
Description

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).

ATC Classification
Drugs
DrugDrug Description
NelfinavirA viral protease inhibitor used in the treatment of HIV infection.
IndinavirA protease inhibitor used to treat HIV infection.
RitonavirAn HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection.
AmprenavirA protease inhibitor used to treat HIV infection.
AtazanavirAn antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV.
SaquinavirAn HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency.
DarunavirA HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies.
FosamprenavirAn antiretroviral agent used for the treatment and postexposure prophylaxis of human immunodeficiency virus (HIV-1) infection.
LepirudinA protein-based direct thrombin inhibitor used to reverse and prevent thrombus formation in heparin-induced thrombocytopenia.
RemikirenFor the treatment of hypertension and heart failure
FosinoprilAn ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics.
TrandolaprilA prodrug of an ACE inhibitor used to treat hypertension, congestive heart failure, and to improve survival following a myocardial infarction.
EnalaprilA prodrug of an ACE inhibitor used to treat hypertension and congestive heart failure.
IsoflurophateFor use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
MoexiprilAn angiotensin converting enzyme inhibitor prodrug used to treat hypertension.
LisinoprilAn ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction.
PerindoprilAn ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction.
QuinaprilAn ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease.
OmapatrilatFor the treatment of hypertension.
SitagliptinAn oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus.
SpiraprilSpirapril is an ACE inhibitor class drug used to treat hypertension.
IlomastatNot Available
GeldanamycinNot Available
PhosphoramidonNot Available
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineNot Available
EnalkirenNot Available
UbenimexAn adjuvant therapy used for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia.
VildagliptinA once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus.
XimelagatranFor the treatment of acute deep vein thrombosis.
PrinomastatInvestigated for use/treatment in brain cancer, lung cancer, and prostate cancer.
ElafinInvestigated for use/treatment in inflammatory disorders (unspecified).
EcabetFor the treatment of reflux oesophagitis and peptic ulcer disease.
RivaroxabanA factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.
SimeprevirA direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4.
SaxagliptinAn DPP-4 inhibitor used for the management of type 2 diabetes mellitus.
IdraparinuxInvestigated for use/treatment in thrombosis, venous thromboembolism, strokes, heart disease, and atrial fibrillation.
OtamixabanInvestigated for use/treatment in thrombosis.
Dabigatran etexilateAn anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation.
Z-Val-Ala-Asp fluoromethyl ketoneNon-methylated, competitive, and irreversible inhibitor of caspase 1, as well as other caspases,1 which can be used directly with purified enzymes. It does not require an esterase to hydrolyze the...
ThiorphanA potent inhibitor of membrane metalloendopeptidase (enkephalinase). Thiorphan potentiates morphine-induced analgesia and attenuates naloxone-precipitated withdrawal symptoms.
TemocaprilTemocapril is an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction).
LinagliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus.
EdoxabanA novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF).
EnalaprilatAn antihypertensive agent used for the management of hypertension when oral therapy is not practical.
IxazomibA monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already.
RacecadotrilRacecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
ImidaprilImidapril has been investigated for the treatment of Kidney, Polycystic, Autosomal Dominant.
DelanzomibDelanzomib has been used in trials studying the treatment of Solid Tumors, Multiple Myeloma, and Lymphoma, Non-Hodgkin.
LetaxabanLetaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome.
UlinastatinUlinastatin has been investigated for the prevention of Cardiovascular Disease and Adverse Reaction to Drug.
S-3304S-3304 has been used in trials studying the treatment of Lung Cancer, Solid Tumors, Non Small Cell Lung Cancer, Stage IIIB Non Small Cell Lung Cancer, and Stage IIIA Non...
DarexabanDarexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.
NafamostatUsed as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement...
SivelestatSivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress Syndrome, Adult.
ZofenoprilZofenopril is employed as both a cardioprotective and anti-hypertensive agent. It is an angiotensin-converting enzyme (ACE) inhibitor.
DelaprilNot Annotated
MelagatranNot Annotated
TelaprevirAn NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections.
BoceprevirA hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy.
FaldaprevirFaldaprevir has been investigated for the treatment of Chronic Hepatitis C.
Human C1-esterase inhibitorA C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema.
Conestat alfaA recombinant C1INH used for the treatment of acute attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency in adults.
FosinoprilatFosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group.
RamiprilatThe active metabolite of the prodrug Ramipril.
PerindoprilatThe active metabolite of the prodrug Perindopril.
QuinaprilatThe active metabolite of the prodrug quinapril.
RamiprilAn ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure.
LopinavirAn HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection.
TipranavirA protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor.
AsunaprevirAsunaprevir is indicated in combination with other agents for the treatment of chronic hepatitis C in adult patients with hepatitis C virus genotypes 1 or 4 and compensated liver cirrhosis....
GabexateNo approved indication.
acetylleucyl-leucyl-norleucinalNot Available
Cholesterol sulfateComponent of human seminal plasma & spermatozoa.
EpicaptoprilNot Available
AntipainAntipain is a serine/cysteine protease inhibitor originally isolated from various strains of actinomycetes. Early studies investigated the potential for antipain to alter DNA damage and chromosomal aberrations in irradiated cells...
RupintrivirInvestigated for use/treatment in viral infection.
Alpha-1-proteinase inhibitorA purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency.
ArgatrobanA synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use.
AlogliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus.
ApixabanAn anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery.
AprotininA serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery.
ABT-341ABT-341 is a potent and selective DPP-4 inhibitor with a structure very similar to sitagliptin (in 2D; the 3D structure is significantly different).
BetrixabanA Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients.
AnagliptinAnagliptin is under investigation for the treatment of LDL Cholesterol, Coronary Disease, Diabetes Mellitus, Glycosylated Hemoglobin, and Dipeptidyl-Peptidase 4 Inhibitors.
BivalirudinA direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention.
BenazeprilAn ACE inhibitor prodrug used to treat hypertension.
FondaparinuxAn anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction.
CandoxatrilCandoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor.
CaptoprilAn ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy.
CilazaprilAn ACE inhibitor used for the management of hypertension and heart failure.
CilastatinA renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.
ChymostatinNot Available
BenzamidineNot Available
BatimastatNot Available
DesirudinIndicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.
CandoxatrilatA dicarboxylic acid monoamide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP,...
NitroaspirinNitroaspirin has been investigated for the treatment of Intermittent Claudication.
CamostatA serine protease indicated in Japan to treat chronic pancreatitis.
BenazeprilatNot Annotated
DabigatranNot Annotated
AvidinAvidin is under investigation in clinical trial NCT00345618 (Clinical Study Assessing Idrabiotaparinux Sodium Injections Once-weekly in Pulmonary Embolism Therapeutic Approach).
CilazaprilatNot Annotated
p-Hydroxymercuribenzoic acidNot Available
2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamideNot Available
2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamideNot Available
GW-813893Not Available
CGS-27023Not Available
CarbomerNot Annotated
Drugs & Drug Targets
DrugTargetType
NelfinavirHIV-1 proteasetarget
NelfinavirCytochrome P450 2C19enzyme
NelfinavirCytochrome P450 3A4enzyme
NelfinavirCytochrome P450 2B6enzyme
NelfinavirCytochrome P450 3A5enzyme
NelfinavirCytochrome P450 3A7enzyme
NelfinavirP-glycoprotein 1transporter
NelfinavirSolute carrier family 22 member 1transporter
NelfinavirSolute carrier organic anion transporter family member 1A2transporter
NelfinavirATP-binding cassette sub-family G member 2transporter
NelfinavirSolute carrier organic anion transporter family member 1B1transporter
NelfinavirCytochrome P450 2D6enzyme
NelfinavirSerum albumincarrier
NelfinavirUDP-glucuronosyltransferase 1-1enzyme
NelfinavirSolute carrier organic anion transporter family member 1B3transporter
NelfinavirSolute carrier organic anion transporter family member 2B1transporter
NelfinavirBile salt export pumptransporter
NelfinavirCytochrome P450 2C9enzyme
IndinavirHuman immunodeficiency virus type 1 proteasetarget
IndinavirCytochrome P450 3A4enzyme
IndinavirCytochrome P450 3A5enzyme
IndinavirCytochrome P450 3A7enzyme
IndinavirP-glycoprotein 1transporter
IndinavirSolute carrier family 22 member 1transporter
IndinavirMultidrug resistance-associated protein 1transporter
IndinavirSolute carrier organic anion transporter family member 1A2transporter
IndinavirSolute carrier organic anion transporter family member 1B1transporter
IndinavirCanalicular multispecific organic anion transporter 1transporter
IndinavirCytochrome P450 2D6enzyme
IndinavirUDP-glucuronosyltransferase 1-1enzyme
IndinavirSolute carrier organic anion transporter family member 2B1transporter
IndinavirBile salt export pumptransporter
RitonavirHuman immunodeficiency virus type 1 proteasetarget
RitonavirCytochrome P450 2D6enzyme
RitonavirCytochrome P450 2C9enzyme
RitonavirCytochrome P450 2C19enzyme
RitonavirCytochrome P450 2B6enzyme
RitonavirCytochrome P450 2C8enzyme
RitonavirP-glycoprotein 1transporter
RitonavirMultidrug resistance-associated protein 1transporter
RitonavirCanalicular multispecific organic anion transporter 1transporter
RitonavirSolute carrier organic anion transporter family member 1A2transporter
RitonavirATP-binding cassette sub-family G member 2transporter
RitonavirSolute carrier organic anion transporter family member 1B1transporter
RitonavirCytochrome P450 1A2enzyme
RitonavirNuclear receptor subfamily 1 group I member 2target
RitonavirSerum albumincarrier
RitonavirCytochrome P450 3A4enzyme
RitonavirCytochrome P450 3A5enzyme
RitonavirCytochrome P450 3A7enzyme
RitonavirUDP-glucuronosyltransferases (UGTs)enzyme
RitonavirSolute carrier organic anion transporter family member 2B1transporter
RitonavirBile salt export pumptransporter
RitonavirAlpha-1-acid glycoprotein 1carrier
RitonavirSolute carrier organic anion transporter family member 1B3transporter
AmprenavirHuman immunodeficiency virus type 1 proteasetarget
AmprenavirCytochrome P450 3A4enzyme
AmprenavirP-glycoprotein 1transporter
AmprenavirMultidrug resistance-associated protein 1transporter
AmprenavirCytochrome P450 2B6enzyme
AmprenavirCytochrome P450 2C19enzyme
AmprenavirCytochrome P450 2C9enzyme
AmprenavirCytochrome P450 2D6enzyme
AmprenavirCytochrome P450 3A5enzyme
AmprenavirSolute carrier organic anion transporter family member 1B1transporter
AtazanavirHuman immunodeficiency virus type 1 proteasetarget
AtazanavirCytochrome P450 3A4enzyme
AtazanavirCytochrome P450 2C9enzyme
AtazanavirP-glycoprotein 1transporter
AtazanavirMultidrug resistance-associated protein 1transporter
AtazanavirSerum albumincarrier
AtazanavirUDP-glucuronosyltransferase 1-1enzyme
AtazanavirSolute carrier organic anion transporter family member 1B1transporter
AtazanavirSolute carrier organic anion transporter family member 1B3transporter
AtazanavirCytochrome P450 2C8enzyme
AtazanavirBile salt export pumptransporter
Atazanaviralpha1-acid glycoproteincarrier
AtazanavirCytochrome P450 1A2enzyme
AtazanavirSolute carrier organic anion transporter family member 2B1transporter
SaquinavirHuman immunodeficiency virus type 1 proteasetarget
SaquinavirCytochrome P450 3A4enzyme
SaquinavirCytochrome P450 3A5enzyme
SaquinavirAlpha-1-acid glycoprotein 1carrier
SaquinavirSerum albumincarrier
SaquinavirCytochrome P450 3A7enzyme
SaquinavirP-glycoprotein 1transporter
SaquinavirSolute carrier family 22 member 1transporter
SaquinavirSolute carrier organic anion transporter family member 1A2transporter
SaquinavirATP-binding cassette sub-family G member 2transporter
SaquinavirSolute carrier organic anion transporter family member 1B1transporter
SaquinavirMultidrug resistance-associated protein 1transporter
SaquinavirCanalicular multispecific organic anion transporter 1transporter
SaquinavirCytochrome P450 2C8enzyme
SaquinavirCytochrome P450 2D6enzyme
SaquinavirSolute carrier organic anion transporter family member 2B1transporter
SaquinavirBile salt export pumptransporter
DarunavirHuman immunodeficiency virus type 1 proteasetarget
DarunavirCytochrome P450 3A4enzyme
DarunavirSolute carrier organic anion transporter family member 1B1transporter
DarunavirP-glycoprotein 1transporter
DarunavirSerum albumincarrier
DarunavirAlpha-1-acid glycoprotein 1carrier
DarunavirCytochrome P450 2D6enzyme
FosamprenavirHuman immunodeficiency virus type 1 proteasetarget
FosamprenavirCytochrome P450 3A4enzyme
LepirudinProthrombintarget
RemikirenRenintarget
FosinoprilAngiotensin-converting enzymetarget
FosinoprilSolute carrier family 15 member 1transporter
FosinoprilSolute carrier family 15 member 2transporter
TrandolaprilAngiotensin-converting enzymetarget
TrandolaprilSolute carrier family 15 member 1transporter
TrandolaprilSolute carrier family 15 member 2transporter
TrandolaprilLiver carboxylesterase 1enzyme
EnalaprilAngiotensin-converting enzymetarget
EnalaprilP-glycoprotein 1transporter
EnalaprilSolute carrier family 15 member 1transporter
EnalaprilSolute carrier family 22 member 6transporter
EnalaprilSolute carrier family 22 member 8transporter
EnalaprilSolute carrier family 22 member 7transporter
EnalaprilSolute carrier organic anion transporter family member 1A2transporter
EnalaprilSerum albumincarrier
IsoflurophateCholinesterasetarget
IsoflurophateAcetylcholinesterasetarget
IsoflurophateCholinesteraseenzyme
IsoflurophateSerum albumincarrier
IsoflurophateSerotransferrintarget
MoexiprilAngiotensin-converting enzymetarget
MoexiprilSolute carrier family 15 member 1transporter
MoexiprilSolute carrier family 15 member 2transporter
LisinoprilAngiotensin-converting enzymetarget
LisinoprilSolute carrier family 15 member 1transporter
LisinoprilSolute carrier family 15 member 2transporter
LisinoprilRenintarget
PerindoprilAngiotensin-converting enzymetarget
PerindoprilSolute carrier family 15 member 1transporter
PerindoprilSolute carrier family 15 member 2transporter
PerindoprilCholinesteraseenzyme
PerindoprilSecreted frizzled-related protein 4target
QuinaprilAngiotensin-converting enzymetarget
QuinaprilSolute carrier family 15 member 1transporter
QuinaprilSolute carrier family 15 member 2transporter
QuinaprilSolute carrier family 22 member 8transporter
QuinaprilLiver carboxylesterase 1enzyme
QuinaprilSerum albumincarrier
OmapatrilatNeprilysintarget
OmapatrilatAngiotensin-converting enzymetarget
SitagliptinDipeptidyl peptidase 4target
SitagliptinCytochrome P450 3A4enzyme
SitagliptinCytochrome P450 2C8enzyme
SitagliptinP-glycoprotein 1transporter
SitagliptinSolute carrier family 22 member 8transporter
SpiraprilAngiotensin-converting enzymetarget
SpiraprilSolute carrier family 15 member 1transporter
SpiraprilSolute carrier family 15 member 2transporter
IlomastatLethal factortarget
IlomastatDisintegrin and metalloproteinase domain-containing protein 28target
IlomastatAggrecan core proteintarget
GeldanamycinHeat shock protein HSP 90-alphatarget
GeldanamycinHeat shock protein HSP 90-betatarget
GeldanamycinEndoplasmintarget
PhosphoramidonNeprilysintarget
PhosphoramidonKell blood group glycoproteintarget
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineCathepsin Btarget
EnalkirenRenintarget
UbenimexBacterial leucyl aminopeptidasetarget
UbenimexLeukotriene A-4 hydrolasetarget
UbenimexSolute carrier family 15 member 1transporter
UbenimexSolute carrier family 15 member 2transporter
VildagliptinDipeptidyl peptidase 4target
XimelagatranProthrombintarget
XimelagatranCytochrome P450 2C9enzyme
ElafinNeutrophil elastasetarget
ElafinMyeloblastintarget
ElafinMyeloperoxidaseenzyme
EcabetNADPH oxidase organizer 1target
EcabetUrease subunit alphatarget
RivaroxabanCoagulation factor Xtarget
RivaroxabanCytochrome P450 3A4enzyme
RivaroxabanCytochrome P450 2J2enzyme
RivaroxabanP-glycoprotein 1transporter
RivaroxabanCytochrome P450 3A5enzyme
RivaroxabanATP-binding cassette sub-family G member 2transporter
SimeprevirNS3 proteasetarget
SimeprevirSerum albumincarrier
SimeprevirCytochrome P450 1A2enzyme
SimeprevirP-glycoprotein 1transporter
SimeprevirSolute carrier organic anion transporter family member 1B1transporter
SimeprevirSolute carrier organic anion transporter family member 1B3transporter
SimeprevirCytochrome P450 3A4enzyme
SimeprevirCanalicular multispecific organic anion transporter 1transporter
SimeprevirATP-binding cassette sub-family G member 2transporter
SimeprevirSolute carrier organic anion transporter family member 2B1transporter
SimeprevirSodium/bile acid cotransportertransporter
SimeprevirBile salt export pumptransporter
SaxagliptinDipeptidyl peptidase 4target
SaxagliptinCytochrome P450 3A4enzyme
SaxagliptinCytochrome P450 3A5enzyme
SaxagliptinMultidrug resistance-associated protein 1transporter
SaxagliptinSolute carrier organic anion transporter family member 4C1transporter
SaxagliptinSolute carrier family 22 member 8transporter
IdraparinuxCoagulation factor Xtarget
OtamixabanCoagulation factor Xtarget
Dabigatran etexilateProthrombintarget
Dabigatran etexilateP-glycoprotein 1transporter
Dabigatran etexilateLiver carboxylesterase 1enzyme
Dabigatran etexilateCocaine esteraseenzyme
Dabigatran etexilateUDP-glucuronosyltransferase 1-9enzyme
Dabigatran etexilateUDP-glucuronosyltransferase 2B7enzyme
Dabigatran etexilateUDP-glucuronosyltransferase 2B15enzyme
Dabigatran etexilateRibosyldihydronicotinamide dehydrogenase [quinone]enzyme
Z-Val-Ala-Asp fluoromethyl ketoneCaspase-1target
ThiorphanNeprilysintarget
TemocaprilSolute carrier family 15 member 1transporter
TemocaprilSolute carrier organic anion transporter family member 1A2transporter
TemocaprilAngiotensin-converting enzymetarget
LinagliptinDipeptidyl peptidase 4target
LinagliptinCytochrome P450 3A4enzyme
LinagliptinP-glycoprotein 1transporter
LinagliptinSolute carrier family 22 member 1transporter
LinagliptinSolute carrier family 22 member 2transporter
LinagliptinSolute carrier family 22 member 3transporter
EdoxabanCoagulation factor Xtarget
EdoxabanP-glycoprotein 1transporter
EnalaprilatAngiotensin-converting enzymetarget
EnalaprilatB1 bradykinin receptortarget
IxazomibCytochrome P450 3A4enzyme
IxazomibCytochrome P450 1A2enzyme
IxazomibCytochrome P450 2B6enzyme
IxazomibCytochrome P450 2C8enzyme
IxazomibCytochrome P450 2D6enzyme
IxazomibCytochrome P450 2C19enzyme
IxazomibCytochrome P450 2C9enzyme
NafamostatIntercellular adhesion molecule 1target
NafamostatTrypsin-1target
NafamostatKallikrein-1target
NafamostatProthrombintarget
NafamostatCoagulation factor Xtarget
NafamostatCoagulation factor XIItarget
NafamostatSolute carrier family 22 member 1transporter
NafamostatSolute carrier family 22 member 2transporter
ZofenoprilAngiotensin-converting enzymetarget
TelaprevirCytochrome P450 3A4enzyme
TelaprevirNS3/4A proteintarget
TelaprevirP-glycoprotein 1transporter
TelaprevirSerum albumincarrier
TelaprevirAlpha-1-acid glycoprotein 1carrier
TelaprevirSolute carrier organic anion transporter family member 1B1target
TelaprevirSolute carrier organic anion transporter family member 2B1target
BoceprevirCytochrome P450 3A4enzyme
BoceprevirCytochrome P450 3A5enzyme
BoceprevirP-glycoprotein 1transporter
BoceprevirNS3/4A proteintarget
Human C1-esterase inhibitorComplement C1r subcomponenttarget
Human C1-esterase inhibitorComplement C1s subcomponenttarget
Human C1-esterase inhibitorPlasma kallikreintarget
Human C1-esterase inhibitorCoagulation factor XIItarget
Human C1-esterase inhibitorProthrombintarget
Human C1-esterase inhibitorCoagulation factor XItarget
Human C1-esterase inhibitorTissue-type plasminogen activatortarget
Conestat alfaComplement C1r subcomponenttarget
Conestat alfaComplement C1s subcomponenttarget
Conestat alfaPlasma kallikreintarget
Conestat alfaCoagulation factor XIItarget
Conestat alfaProthrombintarget
Conestat alfaCoagulation factor XItarget
Conestat alfaTissue-type plasminogen activatortarget
RamiprilAngiotensin-converting enzymetarget
RamiprilSolute carrier family 15 member 1transporter
RamiprilSolute carrier family 15 member 2transporter
RamiprilCholinesteraseenzyme
RamiprilB1 bradykinin receptortarget
LopinavirHuman immunodeficiency virus type 1 proteasetarget
LopinavirCytochrome P450 3A4enzyme
LopinavirCytochrome P450 2D6enzyme
LopinavirCytochrome P450 2C19enzyme
LopinavirP-glycoprotein 1transporter
LopinavirCytochrome P450 2B6enzyme
LopinavirCytochrome P450 2C9enzyme
LopinavirCytochrome P450 3A Subfamilyenzyme
LopinavirSolute carrier organic anion transporter family member 1B1transporter
LopinavirSolute carrier organic anion transporter family member 1B3transporter
LopinavirBile salt export pumptransporter
LopinavirCytochrome P450 1A2enzyme
LopinavirAlpha-1-acid glycoprotein 1carrier
LopinavirSerum albumincarrier
TipranavirHuman immunodeficiency virus type 1 proteasetarget
TipranavirCytochrome P450 3A4enzyme
TipranavirCytochrome P450 2D6enzyme
TipranavirCytochrome P450 2C19enzyme
TipranavirBile salt export pumptransporter
TipranavirUDP-glucuronosyltransferase 1-1enzyme
TipranavirSolute carrier organic anion transporter family member 2B1transporter
TipranavirSolute carrier organic anion transporter family member 1B1transporter
TipranavirSolute carrier organic anion transporter family member 1B3transporter
TipranavirP-glycoprotein 1transporter
AsunaprevirGenome polyproteintarget
AsunaprevirCytochrome P450 3A4enzyme
AsunaprevirCytochrome P450 3A5enzyme
AsunaprevirCytochrome P450 2A6enzyme
AsunaprevirCytochrome P450 2B6enzyme
AsunaprevirCytochrome P450 2C9enzyme
AsunaprevirCytochrome P450 2C19enzyme
AsunaprevirCytochrome P450 2D6enzyme
AsunaprevirSolute carrier organic anion transporter family member 1B1transporter
AsunaprevirSolute carrier organic anion transporter family member 1B3transporter
AsunaprevirSolute carrier organic anion transporter family member 2B1transporter
AsunaprevirP-glycoprotein 1transporter
GabexateTrypsin-1enzyme
GabexateComplement C1s subcomponentenzyme
GabexateComplement C1r subcomponentenzyme
GabexatePlasma kallikreintarget
GabexateProthrombintarget
GabexatePlasminogentarget
acetylleucyl-leucyl-norleucinalProteasome subunit alpha type-7target
Cholesterol sulfateNuclear receptor ROR-alphatarget
EpicaptoprilAngiotensin-converting enzymetarget
EpicaptoprilFEZ-1 proteintarget
EpicaptoprilCarbapenem-hydrolyzing beta-lactamase BlaB-1target
EpicaptoprilMetallo-beta-lactamase L1target
EpicaptoprilBeta-lactamasetarget
EpicaptoprilOrganic hydroperoxide resistance protein, putativetarget
RupintrivirGenome polyproteintarget
Alpha-1-proteinase inhibitorNeutrophil elastasetarget
ArgatrobanProthrombintarget
ArgatrobanCytochrome P450 3A4enzyme
ArgatrobanCytochrome P450 3A5enzyme
ArgatrobanSerum albumincarrier
Argatrobanalpha1-acid glycoproteincarrier
AlogliptinDipeptidyl peptidase 4target
AlogliptinCytochrome P450 3A4enzyme
AlogliptinCytochrome P450 2D6enzyme
ApixabanCoagulation factor Xtarget
ApixabanCytochrome P450 3A4enzyme
ApixabanCytochrome P450 1A2enzyme
ApixabanCytochrome P450 2C8enzyme
ApixabanCytochrome P450 2C9enzyme
ApixabanCytochrome P450 2C19enzyme
ApixabanCytochrome P450 2J2enzyme
ApixabanP-glycoprotein 1transporter
ApixabanATP-binding cassette sub-family G member 2transporter
ApixabanCytochrome P450 3A5enzyme
AprotininTrypsin-1target
AprotininChymotrypsinogen Btarget
AprotininPlasminogentarget
AprotininKallikrein-1target
AprotininCholinesteraseenzyme
ABT-341Dipeptidyl peptidase 4target
BetrixabanP-glycoprotein 1transporter
BetrixabanCoagulation factor Xtarget
BetrixabanPotassium voltage-gated channel subfamily H member 2transporter
BetrixabanProthrombinenzyme
BivalirudinProthrombintarget
BivalirudinMyeloperoxidaseenzyme
BenazeprilAngiotensin-converting enzymetarget
BenazeprilMethylenetetrahydrofolate reductaseenzyme
BenazeprilSolute carrier family 15 member 1transporter
BenazeprilSolute carrier family 15 member 2transporter
FondaparinuxAntithrombin-IIItarget
FondaparinuxCoagulation factor Xtarget
CandoxatrilNeprilysintarget
CandoxatrilAngiotensin-converting enzymetarget
CaptoprilAngiotensin-converting enzymetarget
CaptoprilSerum albumincarrier
Captopril72 kDa type IV collagenasetarget
CaptoprilMatrix metalloproteinase-9target
CaptoprilP-glycoprotein 1transporter
CaptoprilSolute carrier family 15 member 1transporter
CaptoprilSolute carrier family 22 member 6transporter
CaptoprilLeukotriene A-4 hydrolasetarget
CaptoprilB1 bradykinin receptortarget
CilazaprilAngiotensin-converting enzymetarget
CilazaprilP-glycoprotein 1transporter
CilazaprilSolute carrier family 15 member 1transporter
CilazaprilSolute carrier family 15 member 2transporter
CilastatinDipeptidase 1target
CilastatinSolute carrier family 22 member 6transporter
CilastatinSolute carrier family 22 member 8transporter
ChymostatinPeptide amidasetarget
BenzamidineUrokinase-type plasminogen activatortarget
BenzamidineTrypsin-1target
BenzamidineCasein kinase II subunit alphatarget
BenzamidineKallikrein-6target
BenzamidineTrypsin-2target
BenzamidineTrypsin-3target
BenzamidineCopper transport protein ATOX1target
BenzamidineEnoyl-CoA delta isomerase 1, mitochondrialtarget
BenzamidineTrypsintarget
BenzamidineSuppressor of tumorigenicity 14 proteintarget
BenzamidineKallikrein-1target
BatimastatNeutrophil collagenasetarget
BatimastatMacrophage metalloelastasetarget
BatimastatMatrix metalloproteinase-16target
BatimastatDisintegrin and metalloproteinase domain-containing protein 28target
BatimastatA disintegrin and metalloproteinase with thrombospondin motifs 5target
DesirudinCarboxypeptidase A1enzyme
CandoxatrilatNeprilysintarget
NitroaspirinProstaglandin G/H synthase 1target
CamostatTrypsin-1target
CamostatTransmembrane protease serine 2target
CamostatSuppressor of tumorigenicity 14 proteintarget
CamostatCholecystokinintarget
CilazaprilatAngiotensin-converting enzymetarget
p-Hydroxymercuribenzoic acidCarbonic anhydrase 2target
2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamideStromelysin-1target
2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamideStromelysin-1target
GW-813893Prothrombintarget
GW-813893Coagulation factor Xtarget
CGS-27023Macrophage metalloelastasetarget
CGS-27023Interstitial collagenasetarget