Calcium lactate

Identification

Name
Calcium lactate
Accession Number
DB13231
Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Description

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener [1]. Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.

Structure
Thumb
Synonyms
  • 2-Hydroxypropanoic acid calcium salt
  • Calcium 2-hydroxypropanoate (1:2)
  • Calcium dilactate
  • Hemicalcium L-lactate
External IDs
E-327 / INS NO.327 / INS-327
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Calcimax Tab 324mgTablet324 mgOralCarmaran LtÉe1978-12-311997-09-15Canada
Calcium Lactate Tab 10grTablet650 mgOralSwiss Herbal Remedies Ltd.1974-12-312009-08-04Canada
Calcium Lactate Tab 324mgTablet324 mgOralLaboratoire Romilo1980-12-311999-08-18Canada
Calcium Lactate Tab 648mgTablet648 mgOralPharmetics (2011) Inc.1973-12-312000-08-21Canada
Calcium Lactate Tab 648mgTablet648 mgOralVita Health Products Inc1983-12-312002-07-31Canada
Calcium Lactate Tab 648mgTablet648 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Calcium Lactate Tab 650mgTablet650 mgOralShoppers Drug Mart Inc.1978-12-311997-08-15Canada
Calcium Lactate Tab 650mgTablet650 mgOralVita Health Products Inc1957-12-312002-07-31Canada
Calcium Lactate Tab 650mg USPTablet650 mgOralNobel Pharm Enr.1988-12-311997-07-31Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Calcium Ctr SrtCalcium lactate (200 mg) + Vitamin D (80 unit)Tablet, extended releaseOralBioenergy Inc.1981-12-311998-06-03Canada
Calcium Lactate Et Magnesium SulfateCalcium lactate (260 mg) + Magnesium sulfate (65 mg)TabletOralBio Vita1987-12-312005-07-20Canada
Calcium Supplement TabCalcium lactate (10 mg) + Calcium Carbonate (156 mg) + Cholecalciferol (66.6 unit) + Magnesium oxide (66.6 mg)TabletOralHillestad Pharmaceuticals Usa1997-09-042009-09-22Canada
Dicalcine Tab No460Calcium lactate (155 mg) + Calcium gluconate (155 mg)TabletOralHerbes Universelles Inc.1976-12-312009-07-15Canada
MangadynCalcium lactate (175 mg) + Choline bitartrate (30 mg) + Cyanocobalamin (10 mcg) + Manganese sulfate (200 mg) + Pyridoxine (10 mg) + Thiamine (5 mg) + Vitamin C (80 mg) + Vitamin E (10 unit)TabletOralNutri Dyn Products Ltd.1982-12-311997-08-22Canada
Categories
UNII
2URQ2N32W3
CAS number
814-80-2
Weight
Average: 218.218
Monoisotopic: 218.0103289
Chemical Formula
C6H10CaO6
InChI Key
MKJXYGKVIBWPFZ-UHFFFAOYSA-L
InChI
InChI=1S/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2
IUPAC Name
calcium bis(2-hydroxypropanoate)
SMILES
[Ca++].CC(O)C([O-])=O.CC(O)C([O-])=O

Pharmacology

Indication

Indicated for use as the nutritional supplement.

Pharmacodynamics

Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively [2].

Mechanism of action

In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways [2]. Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis [2].

Absorption

In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins [2]. The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport [2].

Volume of distribution

The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity [2].

Protein binding

No pharmacokinetic data available.

Metabolism

In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle [2].

Route of elimination

Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours [2].

Half life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Toxicity

The LDLo of calcium lactate pentahydrate following intravenous administration in mouse is 140 mg/kg [MSDS].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AcetyldigitoxinCalcium lactate may increase the arrhythmogenic activities of Acetyldigitoxin.Approved
AcetyldigoxinCalcium lactate may increase the arrhythmogenic activities of Acetyldigoxin.Experimental
AgmatineThe therapeutic efficacy of Agmatine can be decreased when used in combination with Calcium lactate.Experimental, Investigational
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium lactate.Approved
AlfacalcidolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Alfacalcidol.Approved, Nutraceutical
AmiodaroneThe therapeutic efficacy of Amiodarone can be decreased when used in combination with Calcium lactate.Approved, Investigational
AmlodipineThe therapeutic efficacy of Amlodipine can be decreased when used in combination with Calcium lactate.Approved
AmrinoneThe therapeutic efficacy of Amrinone can be decreased when used in combination with Calcium lactate.Approved
AranidipineThe therapeutic efficacy of Aranidipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
AzelnidipineThe therapeutic efficacy of Azelnidipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
AzimilideThe therapeutic efficacy of Azimilide can be decreased when used in combination with Calcium lactate.Investigational
BarnidipineThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium lactate.Approved
BencyclaneThe therapeutic efficacy of Bencyclane can be decreased when used in combination with Calcium lactate.Experimental
BendroflumethiazideBendroflumethiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved
BenidipineThe therapeutic efficacy of Benidipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
BenzthiazideBenzthiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved
BepridilThe therapeutic efficacy of Bepridil can be decreased when used in combination with Calcium lactate.Approved, Withdrawn
BioallethrinThe therapeutic efficacy of Bioallethrin can be decreased when used in combination with Calcium lactate.Approved, Experimental
CalcidiolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Calcidiol.Approved, Nutraceutical
CalcipotriolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Calcipotriol.Approved
CalcitriolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Calcitriol.Approved, Nutraceutical
Calcium AcetateThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Calcium Acetate.Approved, Investigational
CarboxyamidotriazoleThe therapeutic efficacy of Carboxyamidotriazole can be decreased when used in combination with Calcium lactate.Investigational
CaroverineThe therapeutic efficacy of Caroverine can be decreased when used in combination with Calcium lactate.Experimental
CeftriaxoneThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Ceftriaxone.Approved
ChlorothiazideChlorothiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved, Vet Approved
ChlortetracyclineThe serum concentration of Chlortetracycline can be decreased when it is combined with Calcium lactate.Approved, Investigational, Vet Approved
ChlorthalidoneChlorthalidone may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved
CholecalciferolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Cholecalciferol.Approved, Nutraceutical
CilnidipineThe therapeutic efficacy of Cilnidipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
CinnarizineThe therapeutic efficacy of Cinnarizine can be decreased when used in combination with Calcium lactate.Approved, Investigational
CinoxacinCalcium lactate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Withdrawn
CiprofloxacinCalcium lactate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
ClevidipineThe therapeutic efficacy of Clevidipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
Clodronic AcidThe serum concentration of Clodronic Acid can be decreased when it is combined with Calcium lactate.Approved, Investigational, Vet Approved
CyclandelateThe therapeutic efficacy of Cyclandelate can be decreased when used in combination with Calcium lactate.Approved
CyclopenthiazideCyclopenthiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Experimental
CymarinCalcium lactate may increase the arrhythmogenic activities of Cymarin.Experimental
DarodipineThe therapeutic efficacy of Darodipine can be decreased when used in combination with Calcium lactate.Experimental
DeferiproneThe serum concentration of Deferiprone can be decreased when it is combined with Calcium lactate.Approved
DemeclocyclineThe serum concentration of Demeclocycline can be decreased when it is combined with Calcium lactate.Approved
DeslanosideCalcium lactate may increase the arrhythmogenic activities of Deslanoside.Approved
DigitoxinCalcium lactate may increase the arrhythmogenic activities of Digitoxin.Approved, Investigational
DigoxinCalcium lactate may increase the arrhythmogenic activities of Digoxin.Approved
Digoxin Immune Fab (Ovine)Calcium lactate may increase the arrhythmogenic activities of Digoxin Immune Fab (Ovine).Approved
DihydrotachysterolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Dihydrotachysterol.Approved
DiltiazemThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium lactate.Approved, Investigational
Dipotassium phosphateCalcium lactate can cause a decrease in the absorption of Dipotassium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DobutamineThe therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium lactate.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Calcium lactate.Approved
DotarizineThe therapeutic efficacy of Dotarizine can be decreased when used in combination with Calcium lactate.Investigational
DoxercalciferolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Doxercalciferol.Approved
DoxycyclineThe serum concentration of Doxycycline can be decreased when it is combined with Calcium lactate.Approved, Investigational, Vet Approved
EfonidipineThe therapeutic efficacy of Efonidipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
EltrombopagThe serum concentration of Eltrombopag can be decreased when it is combined with Calcium lactate.Approved
EnoxacinCalcium lactate can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
EperisoneThe therapeutic efficacy of Eperisone can be decreased when used in combination with Calcium lactate.Approved, Investigational
EpitizideEpitizide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Experimental
ErgocalciferolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Ergocalciferol.Approved, Nutraceutical
EstramustineCalcium lactate can cause a decrease in the absorption of Estramustine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
EthosuximideThe therapeutic efficacy of Ethosuximide can be decreased when used in combination with Calcium lactate.Approved
Etidronic acidThe serum concentration of Etidronic acid can be decreased when it is combined with Calcium lactate.Approved
FelodipineThe therapeutic efficacy of Felodipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
FendilineThe therapeutic efficacy of Fendiline can be decreased when used in combination with Calcium lactate.Withdrawn
Fish oilThe therapeutic efficacy of Fish oil can be decreased when used in combination with Calcium lactate.Approved, Nutraceutical
FleroxacinCalcium lactate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
FlumequineCalcium lactate can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
FlunarizineThe therapeutic efficacy of Flunarizine can be decreased when used in combination with Calcium lactate.Approved
FluspirileneThe therapeutic efficacy of Fluspirilene can be decreased when used in combination with Calcium lactate.Approved, Investigational
GabapentinThe therapeutic efficacy of Gabapentin can be decreased when used in combination with Calcium lactate.Approved, Investigational
GallopamilThe therapeutic efficacy of Gallopamil can be decreased when used in combination with Calcium lactate.Investigational
GarenoxacinCalcium lactate can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
GatifloxacinCalcium lactate can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
GemifloxacinCalcium lactate can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
GitoformateCalcium lactate may increase the arrhythmogenic activities of Gitoformate.Experimental
GrepafloxacinCalcium lactate can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Withdrawn
HydrochlorothiazideHydrochlorothiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved, Vet Approved
HydroflumethiazideHydroflumethiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved, Investigational
IbandronateThe serum concentration of Ibandronate can be decreased when it is combined with Calcium lactate.Approved, Investigational
IndapamideIndapamide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved
IsradipineThe therapeutic efficacy of Isradipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
LacidipineThe therapeutic efficacy of Lacidipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
LamotrigineThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium lactate.Approved, Investigational
Lanatoside CCalcium lactate may increase the arrhythmogenic activities of Lanatoside C.Experimental
LercanidipineThe therapeutic efficacy of Lercanidipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
LevetiracetamThe therapeutic efficacy of Levetiracetam can be decreased when used in combination with Calcium lactate.Approved, Investigational
LevofloxacinCalcium lactate can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
LevothyroxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium lactate.Approved
LidoflazineThe therapeutic efficacy of Lidoflazine can be decreased when used in combination with Calcium lactate.Experimental
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium lactate.Approved, Vet Approved
LiotrixThe therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium lactate.Approved
Lipoic AcidCalcium lactate can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Nutraceutical
LomefloxacinCalcium lactate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
LoperamideThe therapeutic efficacy of Loperamide can be decreased when used in combination with Calcium lactate.Approved
Magnesium sulfateThe therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Calcium lactate.Approved, Investigational, Vet Approved
ManidipineThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
MentholThe therapeutic efficacy of Menthol can be decreased when used in combination with Calcium lactate.Approved
MethsuximideThe therapeutic efficacy of Methsuximide can be decreased when used in combination with Calcium lactate.Approved
MethyclothiazideMethyclothiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved
MetildigoxinCalcium lactate may increase the arrhythmogenic activities of Metildigoxin.Experimental
MetolazoneMetolazone may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved
MibefradilThe therapeutic efficacy of Mibefradil can be decreased when used in combination with Calcium lactate.Investigational, Withdrawn
MinocyclineThe serum concentration of Minocycline can be decreased when it is combined with Calcium lactate.Approved, Investigational
MoxifloxacinCalcium lactate can cause a decrease in the absorption of Moxifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
NaftopidilThe therapeutic efficacy of Naftopidil can be decreased when used in combination with Calcium lactate.Investigational
Nalidixic AcidCalcium lactate can cause a decrease in the absorption of Nalidixic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
NemonoxacinCalcium lactate can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
NicardipineThe therapeutic efficacy of Nicardipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
NifedipineThe therapeutic efficacy of Nifedipine can be decreased when used in combination with Calcium lactate.Approved
NiguldipineThe therapeutic efficacy of Niguldipine can be decreased when used in combination with Calcium lactate.Experimental
NiludipineThe therapeutic efficacy of Niludipine can be decreased when used in combination with Calcium lactate.Experimental
NilvadipineThe therapeutic efficacy of Nilvadipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
NimesulideThe therapeutic efficacy of Nimesulide can be decreased when used in combination with Calcium lactate.Approved, Investigational, Withdrawn
NimodipineThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
NisoldipineThe therapeutic efficacy of Nisoldipine can be decreased when used in combination with Calcium lactate.Approved
NitrendipineThe therapeutic efficacy of Nitrendipine can be decreased when used in combination with Calcium lactate.Approved, Investigational
NorfloxacinCalcium lactate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
NylidrinThe therapeutic efficacy of Nylidrin can be decreased when used in combination with Calcium lactate.Approved
OfloxacinCalcium lactate can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
OleandrinCalcium lactate may increase the arrhythmogenic activities of Oleandrin.Experimental, Investigational
OtiloniumThe therapeutic efficacy of Otilonium can be decreased when used in combination with Calcium lactate.Experimental, Investigational
OuabainCalcium lactate may increase the arrhythmogenic activities of Ouabain.Approved
Oxolinic acidCalcium lactate can cause a decrease in the absorption of Oxolinic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
OxytetracyclineThe serum concentration of Oxytetracycline can be decreased when it is combined with Calcium lactate.Approved, Investigational, Vet Approved
PamidronateThe serum concentration of Pamidronate can be decreased when it is combined with Calcium lactate.Approved
ParicalcitolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Paricalcitol.Approved, Investigational
PazufloxacinCalcium lactate can cause a decrease in the absorption of Pazufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
PefloxacinCalcium lactate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
PeruvosideCalcium lactate may increase the arrhythmogenic activities of Peruvoside.Experimental
PinaveriumThe therapeutic efficacy of Pinaverium can be decreased when used in combination with Calcium lactate.Approved
Pipemidic acidCalcium lactate can cause a decrease in the absorption of Pipemidic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
Piromidic acidCalcium lactate can cause a decrease in the absorption of Piromidic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
PolythiazidePolythiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved
PrenylamineThe therapeutic efficacy of Prenylamine can be decreased when used in combination with Calcium lactate.Withdrawn
ProscillaridinCalcium lactate may increase the arrhythmogenic activities of Proscillaridin.Experimental
PrulifloxacinCalcium lactate can cause a decrease in the absorption of Prulifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Investigational
QuinethazoneQuinethazone may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved
RisedronateThe serum concentration of Risedronate can be decreased when it is combined with Calcium lactate.Approved, Investigational
RosoxacinCalcium lactate can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
RufloxacinCalcium lactate can cause a decrease in the absorption of Rufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
SeletracetamThe therapeutic efficacy of Seletracetam can be decreased when used in combination with Calcium lactate.Investigational
SitafloxacinCalcium lactate can cause a decrease in the absorption of Sitafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental, Investigational
Sodium glycerophosphateCalcium lactate can cause a decrease in the absorption of Sodium glycerophosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Sodium phosphateCalcium lactate can cause a decrease in the absorption of Sodium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SparfloxacinCalcium lactate can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Strontium ranelateThe serum concentration of Strontium ranelate can be decreased when it is combined with Calcium lactate.Approved, Withdrawn
Technetium Tc-99m etidronateThe serum concentration of Technetium Tc-99m etidronate can be decreased when it is combined with Calcium lactate.Approved
Technetium Tc-99m medronateThe serum concentration of Technetium Tc-99m medronate can be decreased when it is combined with Calcium lactate.Approved
TemafloxacinCalcium lactate can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
TerodilineThe therapeutic efficacy of Terodiline can be decreased when used in combination with Calcium lactate.Experimental
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Calcium lactate.Approved, Vet Approved
TetrahydropalmatineThe therapeutic efficacy of Tetrahydropalmatine can be decreased when used in combination with Calcium lactate.Investigational
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Calcium lactate.Approved
Tiludronic acidThe serum concentration of Tiludronic acid can be decreased when it is combined with Calcium lactate.Approved, Investigational, Vet Approved
Tolfenamic AcidThe therapeutic efficacy of Tolfenamic Acid can be decreased when used in combination with Calcium lactate.Approved, Investigational
TranilastThe therapeutic efficacy of Tranilast can be decreased when used in combination with Calcium lactate.Approved, Investigational
TrichlormethiazideTrichlormethiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved, Vet Approved
TriethylenetetramineThe serum concentration of Triethylenetetramine can be decreased when it is combined with Calcium lactate.Approved, Investigational
TrimebutineThe therapeutic efficacy of Trimebutine can be decreased when used in combination with Calcium lactate.Approved
TrimethadioneThe therapeutic efficacy of Trimethadione can be decreased when used in combination with Calcium lactate.Approved
TrovafloxacinCalcium lactate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Withdrawn
VerapamilThe therapeutic efficacy of Verapamil can be decreased when used in combination with Calcium lactate.Approved
VinpocetineThe therapeutic efficacy of Vinpocetine can be decreased when used in combination with Calcium lactate.Investigational
WIN 55212-2The therapeutic efficacy of WIN 55212-2 can be decreased when used in combination with Calcium lactate.Experimental
ZiconotideThe therapeutic efficacy of Ziconotide can be decreased when used in combination with Calcium lactate.Approved
Zoledronic acidThe serum concentration of Zoledronic acid can be decreased when it is combined with Calcium lactate.Approved
ZonisamideThe therapeutic efficacy of Zonisamide can be decreased when used in combination with Calcium lactate.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. FDA CFR - Code of Federal Regulations Title 21: Sec. 184.1207 Calcium lactate [Link]
  2. GRAS Notification for the Use of Calcium Lactate in Potato and Vegetable Snacks and Sweetened Crackers [File]
External Links
PubChem Compound
13144
PubChem Substance
347829287
ChemSpider
12592
ChEMBL
CHEMBL2106111
Wikipedia
Calcium_lactate
ATC Codes
A12AA05 — Calcium lactate
MSDS
Download (218 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedPreventionDental Decay1
1, 2Unknown StatusTreatmentRenal Insufficiency,Chronic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TabletOral324 mg
Tablet, extended releaseOral
TabletOral650 mg
TabletOral648 mg
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)> 120MSDS
water solubility48 g/LMSDS
Predicted Properties
PropertyValueSource
Water Solubility191.0 mg/mLALOGPS
logP-0.36ALOGPS
logP-0.47ChemAxon
logS-0.06ALOGPS
pKa (Strongest Acidic)3.78ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity29.68 m3·mol-1ChemAxon
Polarizability7.65 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as carboxylic acid salts. These are ionic derivatives of carboxylic acid.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acid derivatives
Direct Parent
Carboxylic acid salts
Alternative Parents
Secondary alcohols / Organic calcium salts / Monocarboxylic acids and derivatives / Carboxylic acids / Organic zwitterions / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Secondary alcohol / Carboxylic acid salt / Organic calcium salt / Monocarboxylic acid or derivatives / Carboxylic acid / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organic salt / Organic zwitterion
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on June 23, 2017 14:38 / Updated on June 02, 2018 08:47