Calcium lactate

Identification

Name
Calcium lactate
Accession Number
DB13231
Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Description

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener [1]. Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.

Structure
Thumb
Synonyms
  • 2-Hydroxypropanoic acid calcium salt
  • Calcio lactato
  • Calcium 2-hydroxypropanoate (1:2)
  • Calcium dilactate
  • Hemicalcium L-lactate
External IDs
E-327 / INS NO.327 / INS-327
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Calcimax Tab 324mgTablet324 mgOralCarmaran LtÉe1978-12-311997-09-15Canada
Calcium Lactate Tab 10grTablet650 mgOralSwiss Herbal Remedies Ltd.1974-12-312009-08-04Canada
Calcium Lactate Tab 324mgTablet324 mgOralLaboratoire Romilo1980-12-311999-08-18Canada
Calcium Lactate Tab 648mgTablet648 mgOralPharmetics (2011) Inc.1973-12-312000-08-21Canada
Calcium Lactate Tab 648mgTablet648 mgOralVita Health Products Inc1983-12-312002-07-31Canada
Calcium Lactate Tab 648mgTablet648 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Calcium Lactate Tab 650mgTablet650 mgOralShoppers Drug Mart Inc.1978-12-311997-08-15Canada
Calcium Lactate Tab 650mgTablet650 mgOralVita Health Products Inc1957-12-312002-07-31Canada
Calcium Lactate Tab 650mg USPTablet650 mgOralNobel Pharm Enr.1988-12-311997-07-31Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Calcium Ctr SrtCalcium lactate (200 mg) + Vitamin D (80 unit)Tablet, extended releaseOralBioenergy Inc.1981-12-311998-06-03Canada
Calcium Lactate Et Magnesium SulfateCalcium lactate (260 mg) + Magnesium sulfate (65 mg)TabletOralBio Vita1987-12-312005-07-20Canada
Calcium Supplement TabCalcium lactate (10 mg) + Calcium Carbonate (156 mg) + Cholecalciferol (66.6 unit) + Magnesium oxide (66.6 mg)TabletOralHillestad Pharmaceuticals Usa1997-09-042009-09-22Canada
Dicalcine Tab No460Calcium lactate (155 mg) + Calcium gluconate (155 mg)TabletOralHerbes Universelles Inc.1976-12-312009-07-15Canada
MangadynCalcium lactate (175 mg) + Ascorbic acid (80 mg) + Choline bitartrate (30 mg) + Cyanocobalamin (10 mcg) + Manganese sulfate (200 mg) + Pyridoxine (10 mg) + Thiamine (5 mg) + Vitamin E (10 unit)TabletOralNutri Dyn Products Ltd.1982-12-311997-08-22Canada
Pro Enz TabCalcium lactate (333 mg) + Ascorbic acid (30 mg) + Citrus bioflavonoids (30 mg) + Cyanocobalamin (3 mcg) + Manganese (15.4 mg) + Niacin (10 mg) + Nicotinamide (30 mg) + Zinc (1.95 mg)TabletOralAnabolic Laboratories Inc.1970-12-312004-03-15Canada
Categories
UNII
2URQ2N32W3
CAS number
814-80-2
Weight
Average: 218.218
Monoisotopic: 218.0103289
Chemical Formula
C6H10CaO6
InChI Key
MKJXYGKVIBWPFZ-UHFFFAOYSA-L
InChI
InChI=1S/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2
IUPAC Name
calcium bis(2-hydroxypropanoate)
SMILES
[Ca++].CC(O)C([O-])=O.CC(O)C([O-])=O

Pharmacology

Indication

Indicated for use as the nutritional supplement.

Pharmacodynamics

Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively [2].

Mechanism of action

In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways [2]. Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis [2].

Absorption

In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins [2]. The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport [2].

Volume of distribution

The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity [2].

Protein binding

No pharmacokinetic data available.

Metabolism

In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle [2].

Route of elimination

Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours [2].

Half life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Toxicity

The LDLo of calcium lactate pentahydrate following intravenous administration in mouse is 140 mg/kg [MSDS].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
1alpha-Hydroxyvitamin D5The risk or severity of adverse effects can be increased when Calcium lactate is combined with 1alpha-Hydroxyvitamin D5.
3-Aza-2,3-Dihydrogeranyl DiphosphateCalcium lactate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
3,5-diiodothyropropionic acidThe therapeutic efficacy of 3,5-diiodothyropropionic acid can be decreased when used in combination with Calcium lactate.
AbaloparatideThe therapeutic efficacy of Abaloparatide can be decreased when used in combination with Calcium lactate.
AcetyldigitoxinCalcium lactate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
AcetyldigoxinCalcium lactate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigoxin.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium lactate.
AlfacalcidolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Alfacalcidol.
BecocalcidiolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Becocalcidiol.
BendroflumethiazideBendroflumethiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
Food Interactions
Not Available

References

General References
  1. FDA CFR - Code of Federal Regulations Title 21: Sec. 184.1207 Calcium lactate [Link]
  2. GRAS Notification for the Use of Calcium Lactate in Potato and Vegetable Snacks and Sweetened Crackers [File]
External Links
PubChem Compound
13144
PubChem Substance
347829287
ChemSpider
12592
ChEMBL
CHEMBL2106111
Wikipedia
Calcium_lactate
ATC Codes
A12AA05 — Calcium lactate
MSDS
Download (218 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedPreventionDental Decay1
1, 2Unknown StatusTreatmentRenal Insufficiency,Chronic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TabletOral324 mg
Tablet, extended releaseOral
TabletOral650 mg
TabletOral648 mg
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)> 120MSDS
water solubility48 g/LMSDS
Predicted Properties
PropertyValueSource
Water Solubility191.0 mg/mLALOGPS
logP-0.36ALOGPS
logP-0.47ChemAxon
logS-0.06ALOGPS
pKa (Strongest Acidic)3.78ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity29.68 m3·mol-1ChemAxon
Polarizability7.65 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as carboxylic acid salts. These are ionic derivatives of carboxylic acid.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acid derivatives
Direct Parent
Carboxylic acid salts
Alternative Parents
Secondary alcohols / Organic calcium salts / Monocarboxylic acids and derivatives / Carboxylic acids / Organic zwitterions / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Secondary alcohol / Carboxylic acid salt / Organic calcium salt / Monocarboxylic acid or derivatives / Carboxylic acid / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organic salt / Organic zwitterion
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on June 23, 2017 14:38 / Updated on November 05, 2018 17:50