Mineral Supplements

DrugDrug NameDrug Indication
DB11135SeleniumFor the supplementation of total parenteral nutrition to prevent hyposelenemia [FDA Label].
DB00326Calcium glucoheptonateFor treatment of mild hypocalcemia due to neonatal tetany, tetany due to parathyroid deficiency or vitamin D deficiency, and alkalosis, as prophylaxis of hypocalcemia during exchange transfusions, in the treatment of intestinal malabsorption, and to replenish electrolytes.
DB00761Potassium chlorideFor use as an electrolyte replenisher and in the treatment of hypokalemia.
DB03088Pidolic AcidThere is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in a variety of non-prescription, over-the-counter dietary supplement products for cognitive or memory enhancement, there are many studies that suggest that such products or such supplementation do not elicit any kind of cognitive benefit to users [A32981, A32982]. In fact, the general suggestion for any such pidolic acid product is to exercise caution in their recommendation as much more research is necessary [A32981]. Pidolic acid and sodium pidolic acid are, however, used to some extent in skin and hair conditioning agents owing to their humectant characteristics [F53].
DB09125Potassium CitrateFor the management of renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.
DB11068Selenic acidIndicated for use as a nutritional supplement.
DB11093Calcium CitrateFor use as an over the counter calcium supplement.
DB11098Potassium bicarbonatePotassium bicarbonate is used as an antacid, electrolyte replenisher and potassium supplement. It can also be used as an excipient in drug formulations.[L1837] An antacid is a medication used to neutralize gastric acid in a short timeframe after ingestion and the effect is soon overcome by meal-stimulated acid secretion.[A32214]
DB11126Calcium gluconateOral calcium salts are used as dietary supplemental therapy for person who may not get enough calcium in their regular diet. Calcium gluconate is used as a cardioprotective agent in high blood potassium. Calcium gluconate is the antidote for magnesium sulfate toxicity.
DB11127Selenious acid Selenium injection is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration of selenious acid in TPN formulas helps to maintain plasma selenium levels and also to maintain endogenous stores to prevent deficiency [L1922]. Selenium compounds, such as selenium sulfide, are used topically in anti-dandruff shampoos and in cases of seborrhea [L1916]. For the purpose of brevity, selenite will the focus of discussion, and more information about selenium can be obtained at [DB11135].
DB11248Zinc gluconateZinc gluconate is mainly indicated in conditions like zinc deficiency, and can also be administered in adjunctive therapy as an alternative drug of choice in diarrhea [L2088].
DB11348Calcium PhosphateFor use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste [FDA Label] [L851].
DB13142Calcium glubionateCalcium glubionate is indicated to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).
DB13231Calcium lactateIndicated for use as the nutritional supplement.
DB13359Magnesium aspartateNot Available
DB13365Calcium lactate gluconateNot Available
DB13590Calcium pangamateNot Available
DB13620Potassium gluconateBecause of potassium’s wide-ranging roles in the body, low intakes can increase the risk of illness [L2655]. Potassium supplements are indicated to prevent hypokalemia in patients who would be at particular risk if hypokalemia were to develop (e.g., digitalis treated patients with significant cardiac arrhythmias). Potassium deficiency occurs when the rate of loss through renal excretion and/or loss from the gastrointestinal tract is higher than the rate of potassium intake. In addition to serving as a preventative supplement, potassium gluconate also serves as a treatment for decreased potassium levels [L2655], [L2651], [L2657].
DB13749Magnesium gluconateMagnesium gluconate is a mineral supplement which is used to prevent and treat low levels of magnesium. Magnesium is very important for the normal physiologic functioning of cells, nerves, muscles, bones, and the heart. Generally, a well-balanced diet provides the necessary amounts of magnesium for homeostasis. However, certain conditions causing chronic magnesium deficiency may decrease levels of magnesium. These conditions include treatment with diuretics, a poor diet, alcoholism, or other medical conditions (e.g., severe diarrhea/vomiting, stomach/intestinal absorption problems, poorly controlled diabetes) [L2600].
DB13786Magnesium orotateNot Available
DB13800Calcium levulinateThis new application of calcium is intended for use as a food fortifier, to fortify foods like sauces, condiments, beer, beverages, soft drinks, milk and milk products, soy milk and soy products with calcium nutrition [L2765]. Calcium levulinate can be used alone, or with calcium lactate, calcium chloride, and other compounds, either for pharmaceutical tablets, capsules, or injections preparation [L2765]. In essence, calcium levulinate is ultimately a relatively new calcium supplementation option [L2767].
DB00653Magnesium sulfateUsed for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
DB01164Calcium ChlorideFor the treatment of hypocalcemia in those conditions requiring a prompt increase in blood plasma calcium levels, for the treatment of magnesium intoxication due to overdosage of magnesium sulfate, and used to combat the deleterious effects of hyperkalemia as measured by electrocardiographic (ECG), pending correction of the increased potassium level in the extracellular fluid.
DB01377Magnesium oxideIndicated for over-the-counter use as a supplement for cardiovascular and neuromuscular health, and as an antacid for relief of acid indigestion and upset stomach.
DB06724Calcium CarbonateFor relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.
DB09153Sodium chlorideThis intravenous solution is indicated for use in adults and pediatric patients as a source of electrolytes and water for hydration. Also, designed for use as a diluent and delivery system for intermittent intravenous administration of compatible drug additives.
DB09322Zinc sulfateThis medication is a mineral used to treat or prevent low levels of zinc alone and together with oral rehydration therapy (ORT). It is also used as a topical astringent. Zinc Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for TPN.
DB09325Sodium fluorideTo prevent cavities.
DB09407Magnesium chlorideMagnesium chloride is used in several medical and topical (skin related) applications. Magnesium chloride usp, anhydrous uses as electrolyte replenisher, pharmaceutic necessity for hemodialysis and peritoneal dialysis fluids.
DB09472Sodium sulfateindicated for bowel cleansing prior to colonoscopy or barium enema X-ray examination.
DB09484Sodium fluorophosphateSodium monofluorophosphate is indicated for the treatment of cavities
DB11110Magnesium citrateMagnesium citrate has been used in bowel preparations prior to a colonoscopy as a cathartic agent.[T215] It is also used in over-the-counter products to relieve occasional constipation.[L2841] Magnesium citrate can be one of the forms used for the administration of dietary supplements.[L2842]
DB14514Magnesium levulinateNot Available
DB14515Magnesium lactateNot Available
DrugDrug NameTargetType
DB11135SeleniumSelenocysteine lyaseenzyme
DB11135SeleniumGlutathione reductase, mitochondrialenzyme
DB11135SeleniumThioredoxin reductase 1, cytoplasmicenzyme
DB00761Potassium chlorideSolute carrier family 12 member 2target
DB00761Potassium chlorideSolute carrier family 12 member 1target
DB00761Potassium chlorideSolute carrier family 12 member 5target
DB00761Potassium chlorideSolute carrier family 12 member 6target
DB00761Potassium chlorideSolute carrier family 12 member 7target
DB00761Potassium chlorideSolute carrier family 12 member 4target
DB00761Potassium chlorideSolute carrier family 12 member 2transporter
DB00761Potassium chlorideSolute carrier family 12 member 1transporter
DB00761Potassium chlorideSolute carrier family 12 member 5transporter
DB00761Potassium chlorideSolute carrier family 12 member 6transporter
DB00761Potassium chlorideSolute carrier family 12 member 7transporter
DB00761Potassium chlorideSolute carrier family 12 member 4transporter
DB03088Pidolic AcidAlpha-amylase 2Btarget
DB03088Pidolic AcidAngiogenintarget
DB03088Pidolic AcidChondroitinase-Btarget
DB03088Pidolic AcidAlpha-amylase 1target
DB03088Pidolic AcidVascular endothelial growth factor Atarget
DB03088Pidolic AcidPancreatic alpha-amylasetarget
DB03088Pidolic AcidIg lambda-1 chain C regionstarget
DB03088Pidolic AcidIg lambda chain V-II region MGCtarget
DB03088Pidolic AcidTrefoil factor 2target
DB03088Pidolic AcidCytochrome c2target
DB03088Pidolic AcidDisintegrin and metalloproteinase domain-containing protein 28target
DB03088Pidolic AcidEndo-1,4-beta-xylanasetarget
DB03088Pidolic AcidDissimilatory copper-containing nitrite reductasetarget
DB03088Pidolic AcidKeratin-associated protein 5-2target
DB03088Pidolic AcidOrexintarget
DB03088Pidolic AcidC-C motif chemokine 8target
DB03088Pidolic AcidCytochrome c'target
DB03088Pidolic AcidPancreatic alpha-amylaseenzyme
DB11093Calcium CitrateTransient receptor potential cation channel subfamily V member 6transporter
DB11093Calcium CitrateCalbindincarrier
DB11093Calcium CitrateProtein S100-Gcarrier
DB11093Calcium CitrateSodium/calcium exchanger 1transporter
DB11093Calcium CitrateTransient receptor potential cation channel subfamily V member 5transporter
DB11093Calcium CitrateExtracellular calcium-sensing receptortarget
DB11093Calcium CitrateCalreticulintarget
DB11093Calcium CitrateCalcium and integrin-binding protein 1target
DB11093Calcium CitrateProgrammed cell death protein 6target
DB11093Calcium CitrateSorcintarget
DB11093Calcium CitrateCalcineurin B homologous protein 1target
DB11093Calcium CitrateSPARCtarget
DB11093Calcium CitrateCalnexintarget
DB11093Calcium CitrateFibrillin-2target
DB11093Calcium CitrateProtein S100-Btarget
DB11093Calcium CitrateCalsequestrin-2target
DB11093Calcium CitrateRegucalcintarget
DB11093Calcium CitratePeflintarget
DB11093Calcium CitrateProtein S100-A6target
DB11093Calcium CitrateTranslationally-controlled tumor proteintarget
DB11093Calcium CitrateCalcium and integrin-binding family member 2target
DB11093Calcium CitrateProtein S100-A13target
DB11093Calcium CitrateCalsequestrin-1target
DB11093Calcium CitrateNucleobindin-1target
DB11093Calcium CitrateNucleobindin-2target
DB11093Calcium CitrateCalmodulintarget
DB11093Calcium CitrateFibrillin-3target
DB11093Calcium CitrateGrancalcintarget
DB11093Calcium CitrateCalcium-dependent secretion activator 1target
DB11093Calcium CitrateSerum albumincarrier
DB11093Calcium CitrateCalmodulin-2target
DB11093Calcium CitrateCalmodulin-3target
DB11093Calcium CitrateProtein S100-A16target
DB11093Calcium CitrateCalretinintarget
DB11093Calcium CitrateCalcyphosintarget
DB11093Calcium CitrateCalcium-dependent secretion activator 2target
DB11093Calcium CitrateCalreticulin-3target
DB11093Calcium CitrateRyanodine receptor 1transporter
DB11093Calcium CitrateRyanodine receptor 2transporter
DB11093Calcium CitratePolycystic kidney disease 2-like 1 proteintransporter
DB11093Calcium CitrateNeurexin-1target
DB11093Calcium CitrateNeuronal calcium sensor 1target
DB11093Calcium CitrateRyanodine receptor 3transporter
DB11093Calcium CitratePolycystic kidney disease protein 1-like 3transporter
DB11093Calcium CitrateCation channel sperm-associated protein 1transporter
DB11093Calcium CitrateVoltage-dependent L-type calcium channeltransporter
DB11093Calcium CitrateVoltage-dependent P/Q-type calcium channeltransporter
DB11093Calcium CitrateVoltage-dependent T-type calcium channeltransporter
DB11093Calcium CitrateVoltage-dependent R-type calcium channeltransporter
DB11098Potassium bicarbonatePepsintarget
DB11098Potassium bicarbonateHydrogen ionstarget
DB11098Potassium bicarbonateSolute carrier family 12 member 2transporter
DB11098Potassium bicarbonateSolute carrier family 12 member 1transporter
DB11127Selenious acidGlutathione peroxidase 1enzyme
DB11127Selenious acidSelenoprotein Ptransporter
DB11127Selenious acidThioredoxin reductase 1, cytoplasmicenzyme
DB11348Calcium PhosphateSodium-dependent phosphate transporter 1transporter
DB11348Calcium PhosphateSodium-dependent phosphate transporter 2transporter
DB11348Calcium PhosphateSodium-dependent phosphate transport protein 2Atransporter
DB11348Calcium PhosphateSodium-dependent phosphate transport protein 2Btransporter
DB11348Calcium PhosphateSodium-dependent phosphate transport protein 2Ctransporter
DB11348Calcium PhosphateTransient receptor potential cation channel subfamily V member 6transporter
DB11348Calcium PhosphateCalbindincarrier
DB11348Calcium PhosphateProtein S100-Gcarrier
DB11348Calcium PhosphateSodium/calcium exchanger 1transporter
DB11348Calcium PhosphateTransient receptor potential cation channel subfamily V member 5transporter
DB11348Calcium PhosphateExtracellular calcium-sensing receptortarget
DB11348Calcium PhosphateCalreticulintarget
DB11348Calcium PhosphateCalcium and integrin-binding protein 1target
DB11348Calcium PhosphateProgrammed cell death protein 6target
DB11348Calcium PhosphateSorcintarget
DB11348Calcium PhosphateCalcineurin B homologous protein 1target
DB11348Calcium PhosphateSPARCtarget
DB11348Calcium PhosphateCalnexintarget
DB11348Calcium PhosphateFibrillin-2target
DB11348Calcium PhosphateProtein S100-Btarget
DB11348Calcium PhosphateCalsequestrin-2target
DB11348Calcium PhosphateRegucalcintarget
DB11348Calcium PhosphatePeflintarget
DB11348Calcium PhosphateProtein S100-A6target
DB11348Calcium PhosphateTranslationally-controlled tumor proteintarget
DB11348Calcium PhosphateCalcium and integrin-binding family member 2target
DB11348Calcium PhosphateProtein S100-A13target
DB11348Calcium PhosphateCalsequestrin-1target
DB11348Calcium PhosphateNucleobindin-1target
DB11348Calcium PhosphateNucleobindin-2target
DB11348Calcium PhosphateCalmodulintarget
DB11348Calcium PhosphateFibrillin-3target
DB11348Calcium PhosphateGrancalcintarget
DB11348Calcium PhosphateCalcium-dependent secretion activator 1target
DB11348Calcium PhosphateSerum albumincarrier
DB11348Calcium PhosphateCalmodulin-2target
DB11348Calcium PhosphateCalmodulin-3target
DB11348Calcium PhosphateProtein S100-A16target
DB11348Calcium PhosphateCalretinintarget
DB11348Calcium PhosphateCalcyphosintarget
DB11348Calcium PhosphateCalcium-dependent secretion activator 2target
DB11348Calcium PhosphateCalreticulin-3target
DB11348Calcium PhosphateRyanodine receptor 1transporter
DB11348Calcium PhosphateRyanodine receptor 2transporter
DB11348Calcium PhosphatePolycystic kidney disease 2-like 1 proteintransporter
DB11348Calcium PhosphateNeurexin-1target
DB11348Calcium PhosphateNeuronal calcium sensor 1target
DB11348Calcium PhosphateRyanodine receptor 3transporter
DB11348Calcium PhosphatePolycystic kidney disease protein 1-like 3transporter
DB11348Calcium PhosphateCation channel sperm-associated protein 1transporter
DB11348Calcium PhosphateVoltage-dependent L-type calcium channeltransporter
DB11348Calcium PhosphateVoltage-dependent P/Q-type calcium channeltransporter
DB11348Calcium PhosphateVoltage-dependent T-type calcium channeltransporter
DB11348Calcium PhosphateVoltage-dependent R-type calcium channeltransporter
DB13620Potassium gluconateSodium/potassium-transporting ATPase subunit gammaenzyme
DB13620Potassium gluconateSodium/potassium-transporting ATPase subunit alpha-1transporter
DB13620Potassium gluconateSolute carrier family 12 member 1transporter
DB13620Potassium gluconateHydrogen potassium ATPasetransporter
DB13749Magnesium gluconateHexokinaseenzyme
DB13749Magnesium gluconateCreatine kinase B-typeenzyme
DB13749Magnesium gluconateTyrosine-protein kinase ABL1enzyme
DB13749Magnesium gluconateATP synthase subunit delta, mitochondrialenzyme
DB13749Magnesium gluconateAdenylate cyclase type 1enzyme
DB13749Magnesium gluconateGuanylate cyclase soluble subunit alpha-2enzyme
DB13749Magnesium gluconate6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1enzyme
DB13749Magnesium gluconatePhosphoribosylpyrophosphate synthetaseenzyme
DB13749Magnesium gluconateSodium/potassium-transporting ATPase subunit alpha-1enzyme
DB13800Calcium levulinateCalmodulintarget
DB13800Calcium levulinateCalsequestrin-1target
DB13800Calcium levulinateCalretinintarget
DB00653Magnesium sulfateVoltage-dependent calcium channel gamma-1 subunittarget
DB00653Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01164Calcium ChlorideProtein S100-A13target
DB09322Zinc sulfateAlkaline phosphatase, placental-likeenzyme
DB09325Sodium fluorideAlanine aminotransferase 1enzyme
DB09325Sodium fluorideCytochrome c oxidase subunit 1enzyme
DB09472Sodium sulfateCarbonic anhydrase 2target
DB09472Sodium sulfateCarbonic anhydrase 1target
DB14514Magnesium levulinateSodium/potassium-transporting ATPase subunit alpha-1target
DB14515Magnesium lactateSodium/potassium-transporting ATPase subunit alpha-1target