|DB00333||Methadone||For the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence, and pain.|
|DB00531||Cyclophosphamide||Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients. |
|DB00625||Efavirenz||For use in combination treatment of HIV infection (AIDS)|
|DB01156||Bupropion||For the treatment of depression and as aid to smoking cessation.|
|DB01181||Ifosfamide||Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma.|
|DB00238||Nevirapine||For use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.|
|DB00454||Pethidine||Used to control moderate to severe pain.|
|DB00818||Propofol||Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus. |
|DB01037||Selegiline||Monotherapy for initial treatment of Parkinson's disease, as well as an adjunct therapy in patients with a decreased response to levodopa/carbadopa. Also used for the palliative treatment of mild to moderate Alzheimer's disease and at higher doses, for the treatment of depression.|
|DB01221||Ketamine||Ketamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior other general anesthetic agents and as a supplement of low potency agents.[L1336, FDA label]
Reports have indicated a potential use of ketamine as a therapeutic tool for the management of depression when administered in lower doses.[A31873] These reports have increased the interest for ketamine in this area and several clinical trials are launched for this indication.[L1337, A31874]|
|DB00321||Amitriptyline||- Indicated for the treatment of major depressive disorder in adults
- Indicated for the management of neuropathic pain in adults
- Indicated for the prophylactic treatment of chronic tension type headache (CTTH) in adults
- Indicated for the prophylactic treatment of migraine in adults
- Indicated for the the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products. This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.
-Other off-label uses include irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation and insomnia|
|DB01242||Clomipramine||May be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder).
Unlabeled indications include: depression, panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy (limited evidence), autistic disorder (limited evidence), trichotillomania (limited evidence), onchophagia (limited evidence), stuttering (limited evidence), premature ejaculation, and premenstrual syndrome. |
|DB01151||Desipramine||For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management. |
|DB09167||Dosulepin||Indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required.|
- Indicated for the treatment of depression and/or anxiety [FDA Label].
- Indicated for the treatment of depression and/or anxiety associated with different conditions, including alcoholism, organic disease and manic-depressive disorders [FDA Label].
- Indicated for the treatment of insomnia characterized by difficulties with sleep maintenance [L1347].
- Indicated for the short-term (up to 8 days) management of moderate pruritus in adult patients with atopic dermatitis or lichen simplex chronicus [L1344].|
|DB00458||Imipramine||For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older [FDA Label].
May also be used off-label to manage panic disorders with or without agoraphobia, as a second line agent for ADHD in children and adolescents, to manage bulimia nervosa, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, for the treatment of acute stress disorder and posttraumatic stress disorder, and for symptomatic treatment of postherpetic neuralgia and painful diabetic neuropathy [L1349,L1348,A31900,L1351,L1352,L1353,A31904]. |
|DB00540||Nortriptyline||Primarily indicated for the relief of symptoms of depression.|
|DB00726||Trimipramine||For the treatment of depression and depression accompanied by anxiety, agitation or sleep disturbance|
|DB09068||Vortioxetine||Vortioxetine is indicated for the treatment of major depressive disorder (MDD).|
|DB08883||Perampanel||Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.|