Nocturia

Also known as: [D]Nocturia / Nocturnal frequency / Nycturia

DrugDrug NameDrug Description
DB00035DesmopressinDesmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the stimulation of increased plasma osmolarity or decreased circulating blood volume, ADH mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney [T28]. The hormone interacts with V1, V2 or V3 receptors with differing signal cascade systems. Desmopressin displays enhanced antidiuretic potency, fewer pressor effects due to V2-selective actions, and a prolonged half-life and duration of action compared to endogenous ADH [A31661]. It has been employed clinically since 1972 and is available in various formulations including intranasal solution, intravenous solution, oral tablet and oral lyophilisate [A31662]. Desmopressin is indicated for the treatment of polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. It was also newly approved for the treatment of mild classical hemophilia and von Willebrand's disease for minor surgeries. The active ingredient in most formulations is desmopressin acetate. Nocdurna, or desmopressin acetate, was approved by the FDA on June 21st, 2018 for the treatment of nocturia due to nocturnal polyuria in adults. It is available as a sublingual tablet.
DrugDrug NamePhaseStatusCount
DB11734Fedovapagon1Completed1
DB01167Itraconazole1Completed1
DB01045Rifampicin1Completed1
DB00035Desmopressin2Completed1
DB00035Desmopressin2Recruiting1
DB00035Desmopressin2Terminated1
DB11734Fedovapagon2Completed1
DB01065Melatonin2Unknown Status1
DB06207Silodosin2Completed1
DB06413Armodafinil2 / 3Completed1
DB00035Desmopressin2 / 3Terminated1
DB11734Fedovapagon2 / 3Completed1
DB06702Fesoterodine2 / 3Terminated1
DB00996Gabapentin2 / 3Completed1
DB01591Solifenacin2 / 3Completed1
DB00035Desmopressin3Completed7
DB00035Desmopressin3Terminated1
DB00286Conjugated estrogens4Completed1
DB00496Darifenacin4Withdrawn1
DB00035Desmopressin4Completed1
DB00035Desmopressin4Unknown Status1
DB00783Estradiol4Completed1
DB06207Silodosin4Completed1
DB00706Tamsulosin4Unknown Status1
DB00035DesmopressinNot AvailableCompleted1
DB00035DesmopressinNot AvailableRecruiting1
DB00999HydrochlorothiazideNot AvailableCompleted1
DB08893MirabegronNot AvailableCompleted1