Congenital Adrenal Hyperplasia (CAH)

Also known as: Congenital Adrenal Hyperplasia / Wilkins disease / Adrenal Hyperplasia, Congenital / Adrenal virilism / Androgenital syndrome / Adrenogenital syndrome NOS / Adrenogenital syndrome congenital / Adrenogenital Syndrome

DrugDrug NameDrug Description
DB00443BetamethasoneA glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
DB00297BupivacaineA widely used local anesthetic agent. [PubChem]
DB01380Cortisone acetateCortisone acetate is a steroid hormone that has both glucocoriticoid and mineral corticoid activities. Corticosteroids are used to provide relief for inflamed areas of the body. They lessen swelling, redness, itching, and allergic reactions. They are often used as part of the treatment for a number of different diseases, such as severe allergies or skin problems, asthma, or arthritis. Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called CBG, corticosteroid-binding protein), whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor.
DB01234DexamethasoneAn anti-inflammatory 9-fluoro-glucocorticoid.
DB00741HydrocortisoneThe main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
DB00959MethylprednisoloneA prednisolone derivative with similar anti-inflammatory action.
DB00860PrednisoloneA glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
DB00635PrednisoneA synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.
DB00620TriamcinoloneTriamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis.[L8255] Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain,[L8264] or first line as a topical treatment of corticosteroid responsive dermatoses.[L8249] Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate.[L8246,L8249,L8252,L8255,L8258,L8261,L8264] Triamcinolone was granted FDA approval on 3 December 1957.[L8243]
DrugDrug NameTargetType
DB00443BetamethasoneGlucocorticoid receptortarget
DB00443BetamethasoneCytochrome P450 3A4enzyme
DB00443BetamethasoneP-glycoprotein 1transporter
DB00443BetamethasoneCytochrome P450 19A1enzyme
DB00443BetamethasoneCytochrome P450 3A5enzyme
DB00297BupivacaineSodium channel protein type 10 subunit alphatarget
DB00297BupivacaineProstaglandin E2 receptor EP1 subtypetarget
DB00297BupivacaineCytochrome P450 3A4enzyme
DB00297BupivacaineCytochrome P450 2C19enzyme
DB00297BupivacaineCytochrome P450 2D6enzyme
DB01380Cortisone acetateGlucocorticoid receptortarget
DB01380Cortisone acetateCytochrome P450 3A4enzyme
DB01380Cortisone acetateCytochrome P450 3A5enzyme
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneP-glycoprotein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB01234DexamethasoneCytochrome P450 11B1, mitochondrialenzyme
DB00741HydrocortisoneAnnexin A1target
DB00741HydrocortisoneGlucocorticoid receptortarget
DB00741HydrocortisoneSex hormone-binding globulincarrier
DB00741HydrocortisoneCytochrome P450 3A4enzyme
DB00741HydrocortisoneCytochrome P450 3A5enzyme
DB00741HydrocortisoneCytochrome P450 3A7enzyme
DB00741HydrocortisoneP-glycoprotein 1transporter
DB00741HydrocortisoneSolute carrier organic anion transporter family member 1A2transporter
DB00741HydrocortisoneCytochrome P450 11B1, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 11B2, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 2C8enzyme
DB00741HydrocortisoneCorticosteroid-binding globulincarrier
DB00741HydrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB00741Hydrocortisone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB00741HydrocortisoneSolute carrier family 22 member 8transporter
DB00959MethylprednisoloneGlucocorticoid receptortarget
DB00959MethylprednisoloneCytochrome P450 3A4enzyme
DB00959MethylprednisoloneP-glycoprotein 1transporter
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneP-glycoprotein 1transporter
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneP-glycoprotein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1target
DB00635PrednisoneCytochrome P450 3A5enzyme
DB00620TriamcinoloneCorticosteroid-binding globulincarrier
DB00620TriamcinoloneGlucocorticoid receptortarget
DB00620TriamcinoloneCytochrome P450 3A4enzyme
DB00620TriamcinoloneProstaglandin G/H synthase 2enzyme
DB00620TriamcinoloneCholinesteraseenzyme
DB00620TriamcinoloneCytochrome P450 3A5enzyme
DB00620TriamcinoloneCytochrome P450 3A7enzyme
DB00620TriamcinoloneSerum albumincarrier
DrugDrug NamePhaseStatusCount
DB05812Abiraterone1Recruiting1
DB00741Hydrocortisone1Completed1
DB00741Hydrocortisone1Recruiting1
DB12512Verucerfont1Withdrawn1
DB00741Hydrocortisone1 / 2Completed1
DB14541Hydrocortisone cypionate1 / 2Completed1
DB01115Nifedipine1 / 2Completed1
DB05812Abiraterone2Not Yet Recruiting1
DB00687Fludrocortisone2Not Yet Recruiting1
DB00499Flutamide2Active Not Recruiting1
DB00741Hydrocortisone2Active Not Recruiting1
DB00741Hydrocortisone2Completed2
DB00741Hydrocortisone2Not Yet Recruiting1
DB01006Letrozole2Active Not Recruiting1
DB01234Dexamethasone3Completed1
DB01234Dexamethasone3Suspended1
DB00741Hydrocortisone3Active Not Recruiting1
DB00741Hydrocortisone3Completed1
DB00741Hydrocortisone3Suspended1
DB00860Prednisolone3Completed1
DB00860Prednisolone3Suspended1
DB00635Prednisone3Completed1
DB00635Prednisone3Suspended1
DB01380Cortisone acetate4Recruiting1
DB01234Dexamethasone4Recruiting1
DB00741Hydrocortisone4Recruiting1
DB00860Prednisolone4Recruiting1
DB00635Prednisone4Recruiting1
DB01132PioglitazoneNot AvailableCompleted1