Serotransferrin
Details
- Name
- Serotransferrin
- Synonyms
- Beta-1 metal-binding globulin
- Siderophilin
- Transferrin
- Gene Name
- TF
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037031|Serotransferrin MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVK KASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVV KKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPC ADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRD QYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKE FQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKP VKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGK CGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWN IPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAF RCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLAR APNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKL HDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP
- Number of residues
- 698
- Molecular Weight
- 77063.195
- Theoretical pI
- 7.13
- GO Classification
- Functionsferric iron binding / ferric iron transmembrane transporter activity / ferrous iron binding / transferrin receptor bindingProcessesblood coagulation / cellular iron ion homeostasis / cellular response to iron ion / ferrous iron import into cell / iron ion homeostasis / platelet activation / platelet degranulation / positive regulation of receptor-mediated endocytosis / regulation of protein stability / retina homeostasis / transferrin transport / transmembrane transportComponentsapical plasma membrane / basal part of cell / basal plasma membrane / blood microparticle / cell surface / coated pit / cytoplasmic membrane-bounded vesicle / early endosome / endocytic vesicle / endosome membrane / extracellular exosome / extracellular region / extracellular space / extrinsic component of external side of plasma membrane / HFE-transferrin receptor complex / late endosome / perinuclear region of cytoplasm / recycling endosome / secretory granule lumen / vesicle
- General Function
- Transferrin receptor binding
- Specific Function
- Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
- Pfam Domain Function
- Transferrin (PF00405)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0021268|Serotransferrin (TF) ATGAGGCTCGCCGTGGGAGCCCTGCTGGTCTGCGCCGTCCTGGGGCTGTGTCTGGCTGTC CCTGATAAAACTGTGAGATGGTGTGCAGTGTCGGAGCATGAGGCCACTAAGTGCCAGAGT TTCCGCGACCATATGAAAAGCGTCATTCCATCCGATGGTCCCAGTGTTGCTTGTGTGAAG AAAGCCTCCTACCTTGATTGCATCAGGGCCATTGCGGCAAACGAAGCGGATGCTGTGACA CTGGATGCAGGTTTGGTGTATGATGCTTACCTGGCTCCCAATAACCTGAAGCCTGTGGTG GCAGAGTTCTATGGGTCAAAAGAGGATCCACAGACTTTCTATTATGCTGTTGCTGTGGTG AAGAAGGATAGTGGCTTCCAGATGAACCAGCTTCGAGGCAAGAAGTCCTGCCACACGGGT CTAGGCAGGTCCGCTGGGTGGAACATCCCCATAGGCTTACTTTACTGTGACTTACCTGAG CCACGTAAACCTCTTGAGAAAGCAGTGGCCAATTTCTTCTCGGGCAGCTGTGCCCCTTGT GCGGATGGGACGGACTTCCCCCAGCTGTGTCAACTGTGTCCAGGGTGTGGCTGCTCCACC CTTAACCAATACTTCGGCTACTCGGGAGCCTTCAAGTGTCTGAAGGATGGTGCTGGGGAT GTGGCCTTTGTCAAGCACTCGACTATATTTGAGAACTTGGCAAACAAGGCTGACAGGGAC CAGTATGAGCTGCTTTGCCTGGACAACACCCGGAAGCCGGTAGATGAATACAAGGACTGC CACTTGGCCCAGGTCCCTTCTCATACCGTCGTGGCCCGAAGTATGGGCGGCAAGGAGGAC TTGATCTGGGAGCTTCTCAACCAGGCCCAGGAACATTTTGGCAAAGACAAATCAAAAGAA TTCCAACTATTCAGCTCTCCTCATGGGAAGGACCTGCTGTTTAAGGACTCTGCCCACGGG TTTTTAAAAGTCCCCCCCAGGATGGATGCCAAGATGTACCTGGGCTATGAGTATGTCACT GCCATCCGGAATCTACGGGAAGGCACATGCCCAGAAGCCCCAACAGATGAATGCAAGCCT GTGAAGTGGTGTGCGCTGAGCCACCACGAGAGGCTCAAGTGTGATGAGTGGAGTGTTAAC AGTGTAGGGAAAATAGAGTGTGTATCAGCAGAGACCACCGAAGACTGCATCGCCAAGATC ATGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAG TGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACA CCAGAGGCAGGGTATTTTGCTGTAGCAGTGGTGAAGAAATCAGCTTCTGACCTCACCTGG GACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAAC ATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGT GAAGGTTGTGCCCCTGGGTCTAAGAAAGACTCCAGTCTCTGTAAGCTGTGTATGGGCTCA GGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTC AGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAAC ACTGGGGGAAAAAACCCTGATCCATGGGCTAAGAATCTGAATGAAAAAGACTATGAGTTG CTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGA GCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTA CGTCAACAGCAGCACCTATTTGGAAGCAACGTAACTGACTGCTCGGGCAACTTTTGTTTG TTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTT CATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAAC CTGAGAAAATGCTCCACCTCATCACTCCTGGAAGCCTGCACTTTCCGTAGACCTTAA
- Chromosome Location
- 3
- Locus
- 3q22.1
- External Identifiers
Resource Link UniProtKB ID P02787 UniProtKB Entry Name TRFE_HUMAN GenBank Protein ID 339453 GenBank Gene ID M12530 GenAtlas ID TF HGNC ID HGNC:11740 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01370 Aluminium approved, investigational unknown Details DB00893 Iron Dextran approved, vet_approved unknown substrate Details DB01294 Bismuth subsalicylate approved, vet_approved unknown Details DB05260 Gallium nitrate approved, investigational unknown binder Details DB09130 Copper approved, investigational unknown Details DB00515 Cisplatin approved unknown Details DB11397 Dichlorvos vet_approved unknown Details DB00677 Isoflurophate approved, investigational, withdrawn unknown Details DB01592 Iron approved unknown Details DB01593 Zinc approved, investigational unknown Details DB06757 Manganese approved, nutraceutical unknown Details DB11136 Chromium approved unknown binder Details DB11182 Rose bengal approved, investigational unknown binder Details DB13949 Ferric cation approved unknown binder Details DB14487 Zinc acetate approved, investigational unknown Details DB14488 Ferrous gluconate approved unknown Details DB14489 Ferrous succinate approved unknown Details DB14490 Ferrous ascorbate approved unknown Details DB14491 Ferrous fumarate approved unknown Details DB14501 Ferrous glycine sulfate approved unknown Details DB14517 Aluminium phosphate approved, investigational unknown Details DB14518 Aluminum acetate approved, investigational unknown Details DB14520 Tetraferric tricitrate decahydrate approved unknown binder Details DB14526 Chromic citrate experimental unknown Details DB14527 Chromic nitrate approved unknown Details DB14528 Chromium gluconate approved unknown Details DB14529 Chromium nicotinate approved, experimental unknown Details DB14530 Chromous sulfate approved unknown Details DB14533 Zinc chloride approved, investigational unknown ligand Details DB13257 Ferrous sulfate anhydrous approved unknown substrate Details DB14548 Zinc sulfate, unspecified form approved, experimental unknown ligand Details DB06215 Ferumoxytol approved, investigational no binder Details DB06784 Gallium citrate Ga-67 approved no binder Details