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Displaying drugs 76 - 100 of 419 in total
Viomycin is a tuberactinomycin antibiotic that was used to treat Mycobacterium tuberculosis until it was replaced by the less toxic capreomycin. These drugs bind RNA in bacterial ribosomes and inhibit protein synthesis. Viomycin was derived from the actinomycete Streptomyces puniceus.
Approved
Matched Description: … These drugs bind RNA in bacterial ribosomes and inhibit protein synthesis. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice...
Approved
Investigational
Matched Synonyms: … 1-cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea
Matched Description: … It was first introduced in 1984 [A179491] and is available in various countries including Canada and ... [A179485] Glipizide was first approved by the FDA in 1994 and is available in extended-release tablets ... onset of action with the shortest half-life and duration of action, reducing the risk for long-lasting …
Matched Mixtures name: … Glipizide and Metformin HCl ... Glipizide and Metformin HCl ... Glipizide and Metformin Hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism …
Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug developed specifically targeting FLT3, as other agents with FLT3 inhibition activities were investigated with other targets in mind. Additionally, quizartinib also demonstrates inhibitory activity toward FLT3 with internal tandem duplication (ITD), although...
Approved
Investigational
Matched Synonyms: … Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea
Matched Iupac: … morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0²,⁶]dodeca-1(8),3,5,9,11-pentaen-4-yl}phenyl)urea
Matched Description: … Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug ... thus poorer overall survival and higher risk of relapse. ... anthracycline induction and standard cytarabine consolidation, followed by a maintenance monotherapy …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also...
Approved
Investigational
Matched Synonyms: … N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
Matched Description: … Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. ... in tumour cell proliferation and tumour angiogenesis. ... It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervous system (CNS) depression that ranges from...
Approved
Illicit
Matched Synonyms: … Allylbarbituric acid ... iso-butylallylbarbituric acid ... 5-allyl-5-isobutylbarbituric acid
Matched Description: … Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens ... headaches, butalbital is often combined with one or more therapeutic agents, such as acetylsalicylic acid ... , acetaminophen, aspirin, and caffeine. …
Matched Mixtures name: … Butalbital, Aspirin, and Caffeine ... Butalbital, Aspirin and Caffeine ... Butalbital, Aspirin, and Caffeine …
Matched Categories: … Hypnotics and Sedatives …
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Approved
Investigational
Matched Synonyms: … Phenobarbituric Acid ... Phenylethylbarbituric Acid ... 5-Ethyl-5-phenylbarbituric acid
Matched Description: … It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents ... A barbituric acid derivative that acts as a nonselective central nervous system depressant. …
Matched Mixtures name: … Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide ... Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide …
Matched Categories: … Excitatory Amino Acid Agents ... Excitatory Amino Acid Antagonists ... Barbiturates and Derivatives ... Hypnotics and Sedatives ... Phenobarbital and similars …
An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
Approved
Matched Synonyms: … 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid ... (±)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid ... α-DL-1-methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbituric acid
Matched Categories: … Hypnotics and Sedatives …
Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, valsartan, and irbesartan. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of aldosterone...
Approved
Investigational
Matched Synonyms: … hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid ... methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid
Matched Iupac: … )-2-propyl-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylic acid
Matched Description: … aldosterone and ADH, cardiac stimulation, and renal reabsorption of sodium, among others. ... and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of ... preventing ventricular hypertrophy and remodelling. …
Matched Mixtures name: … Amlodipine and olmesartan Medoxomil ... Amlodipine and olmesartan Medoxomil ... Amlodipine and olmesartan Medoxomil …
Matched Categories: … olmesartan medoxomil and diuretics ... olmesartan medoxomil and amlodipine ... Angiotensin II Antagonists and Calcium Channel Blockers ... Angiotensin II receptor blockers (ARBs) and diuretics ... olmesartan medoxomil, amlodipine and hydrochlorothiazide …
Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.
Approved
Investigational
Matched Synonyms: … 6β-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanic acid ... oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Matched Iupac: … carbonyl)amino]-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Matched Description: … It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and
Ammonium chloride is an inorganic compound with the formula NH4Cl. It is highly soluble in water producing mildly acidic solutions.
Approved
Investigational
Vet approved
Matched Mixtures name: … Cough and Allergy Syrup With Codeine …
Matched Categories: … Blood and Blood Forming Organs ... Genito Urinary System and Sex Hormones ... Blood Substitutes and Perfusion Solutions …
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Approved
Matched Description: … to thymidylic acid. ... It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Fluorouracil and prodrugs ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …
Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium ion, when in water. Although ammonia is used as a food additive in the anhydrous form and serves as a...
Approved
Matched Description: … normally present in all tissues constituting a metabolic pool, where it is mostly taken up by glutamic acid ... pharmaceutical and commercial products, it is caustic and hazardous when concentrated. ... and take part in transamination and other reactions, including the synthesis of protein by the Krebs-Hanseleit …
Matched Mixtures name: … Physician EZ Use Joint Tunnel and Trigger Kit ... CVS Health Medication and Topical Refill Pouch ... JTT Physicians Joint, Tunnel and Trigger …
Ammonia N 13 Injection, USP is a positron emitting radiopharmaceutical that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging. The active ingredient, [13N] ammonia, has the molecular formula of 13NH3 with a molecular weight of 16.02. Ammonia N 13 Injection, USP is used for imaging...
Approved
An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.
Approved
Matched Description: … An anti-infective agent that is used topically to treat skin infections and orally for urinary tract …
Matched Mixtures name: … Sodium Sulfacetamide and Sulfur Clarifying Wash in a Urea Vehicle ... Salicylic Acid 2% /sodium Sulfacetamide Monohydrate 8% ... Salicylic Acid 2% / Sodium Sulfacetamide Monohydrate 8% …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Proxibarbal is a derivative of barbiturates, which has been used to treat migraines. Proxibarbal was approved in France but was withdrawn from the market due to the risk of inducing immunoallergic thrombocytopenia .
Approved
Matched Categories: … Hypnotics and Sedatives …
Human growth hormone (HGH), also known as somatotropin, is a peptide hormone that is synthesized and secreted by the somatotropic cells of the anterior pituitary gland. Growth hormone plays an essential role in growth regulation during childhood as well as other basal metabolic functions, muscle and fat mass regulation, blood...
Approved
Investigational
Matched Description: … in a strain of _Escherichia coli_, recombinant HGH is a polypeptide hormone that contains 191 amino acid ... fat mass regulation, blood glucose level regulation, and lipid regulation in both children and adults ... Human growth hormone (HGH), also known as somatotropin, is a peptide hormone that is synthesized and
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …
Matched Products: … ZOMACTON Powder and Solvent for Solution for Injection 10mg ... ZOMACTON Powder and Solvent for Solution for Injection 4 mg ... GENOTROPIN® 12MG POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
Nitrofural or nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Nitrofural has also been administered orally in the treatment of trypanosomiasis. Except for topical drug products formulated for dermatologic application, the FDA withdrew its approval...
Approved
Investigational
Vet approved
Withdrawn
Matched Iupac: … [(E)-[(5-nitrofuran-2-yl)methylidene]amino]urea
Matched Description: … It is used for superficial wounds, burns, ulcers, and skin infections. ... Nitrofural or nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive …
Matched Categories: … Antiseptics and Disinfectants ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Agents Against Leishmaniasis and Trypanosomiasis ... Antiparasitic Products, Insecticides and Repellents …
An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists).
Approved
Investigational
Matched Iupac: … (4S,7R)-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaen-4-yl]urea
Matched Description: … It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors …
Matched Categories: … Ergot Alkaloids and Derivatives ... Genito Urinary System and Sex Hormones …
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly...
Approved
Matched Description: … Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated ... mainly for asthma, bronchospasm, and COPD. ... methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and
Matched Mixtures name: … Theophylline 4mg and 5% Dextrose Inj ... Theophylline 1.6mg and 5% Dextrose Inj ... Theophylline 0.8mg and 5% Dextrose Inj …
Matched Categories: … Xanthines and Adrenergics ... theophylline and adrenergics …
Polymyxin B was discovered in the 1940s . They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes . Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram-negative cocci,...
Approved
Vet approved
Matched Description: … Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line ... All gram-positive bacteria, fungi, and the gram-negative cocci, are resistant[A176426]. ... Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic …
Matched Mixtures name: … Neomycin and Polymyxin B Sulfates and Bacitracin Zinc ... Neomycin and Polymyxin B Sulfates and Dexamethasone ... Neomycin and Polymyxin B Sulfates and Hydrocortisone …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Ophthalmological and Otological Preparations …
A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a...
Approved
Vet approved
Matched Description: … It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses …
Matched Categories: … Miscellaneous Anxiolytics Sedatives and Hypnotics …
Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subunit alpha. Cytochrome P450 2C19, Cytochrome...
Approved
Investigational
Withdrawn
Matched Description: … Mephenytoin and oxazolidinedione derivatives are associated with higher incidences of blood dyscrasias ... Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2B6, Cytochrome P450 1A2, and
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. ... has also been investigated for several other indications such as bipolar disorder, retina protection, and
Matched Categories: … Phenytoin and Prodrugs ... Metabolic Side Effects of Drugs and Substances …
Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conventional therapy. Eslicarbazepine acetate is a prodrug that is rapidly converted to eslicarbazepine, the primary active metabolite in the body....
Approved
Matched Description: … Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and ... Eslicarbazepine acetate is marketed as Aptiom in North America and Zebinix or Exalief in Europe. ... , but it is known that it does exert anticonvulsant activity by inhibiting repeated neuronal firing and
Matched Categories: … Eslicarbazepine and prodrugs …
Prostate cancer is the most common non-cutaneous malignancy affecting men in North America - despite this, an ongoing challenge in prostate cancer therapy is the difficulty in imaging the extent and location of tumor metastases and recurrences. The images generated by positron emission tomography (PET) are less detailed than those...
Approved
Investigational
Matched Iupac: … 2S)-2-({[(1S)-1-carboxy-5-{[6-(¹⁸F)fluoropyridin-3-yl]formamido}pentyl]carbamoyl}amino)pentanedioic acid
Matched Description: … Piflufolastat F18, also called [F-18]-DCFPyL, is a urea-based radiopharmaceutical that binds to PSMA ... location of tumor metastases and recurrences. ... and allows for the visualization of cancerous prostate tissue. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 76 - 100 of 419 in total