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Displaying drugs 276 - 300 of 10941 in total

Niraparib

Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, fallopian tube, or...
Approved
Investigational
Matched Description: … Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. ... [A253248] First approved by the FDA on March 27, 2017,[A253912] niraparib is used to treat epithelial ... [L43277] Niraparib was approved by the European Commission on November 16, 2017 [L43742] and by Health …

Copanlisib

Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exists in different isoforms and is often overexpressed in hematological malignancies. Copanlisib was granted accelerated...
Approved
Investigational

Von Willebrand factor human

The human von Willebrand factor (vWF) is a human plasma-derived vWF, an endogenous large multimeric plasma glycoprotein involved in hemostasis. It serves a dual role in hemostasis by mediating platelet adhesion and aggregation at the site of blood vessel injury and stabilizing procoagulant factor VIII (FVIII). Exogenous sources of vWF...
Approved
Investigational
Matched Description: … It was first approved by the FDA in 2015. ... The human von Willebrand factor (vWF) is a human plasma-derived vWF, an endogenous large multimeric plasma …

Plasminogen

Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as fibrinolysin - as part of the fibrinolytic pathway that breaks down fibrin blood clots. This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond...
Approved
Matched Description: … )[L34620] for the treatment of type 1 plasminogen deficiency (hypoplasminogenemia). ... to form on the mucous membranes of patients, providing an unmet medical need for patients with this ... [L34635] In June 2021, the FDA approved a plasma-derived plasminogen (Ryplazim, human plasminogen-tvmh …

Givosiran

Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a genetic...
Approved
Investigational
Matched Description: … Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical ... [L10202] Givosiran represents an important step forward in the treatment of acute hepatic porphyria as ... patisiran]), a new class of drugs promising an important and exciting step forward in the treatment of …

Iodine

Iodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may result from contaminated wounds. Additionally, iodine has been studied in the treatment of fibrocystic disease and breast cancer.[A3413,A192153,A192156,A192159]
Approved
Investigational
Matched Description: … Iodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may …
Matched Mixtures name: … New Chapter's D'adamo 4 Your Type Multiple for Type O …

Loxoprofen

Loxoprofen is a propionic acid derivative non-steroidal anti-inflammatory drug. It is marketed under the trade name Loxonin in Brazil, Mexico and Japan by Sankyo, as Loxomac in India, and as Oxeno in Argentina. A transdermal preparation was approved for use in Japan in January 2006.
Approved
Matched Iupac: … 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid …
Matched Description: … Loxoprofen is a propionic acid derivative non-steroidal anti-inflammatory drug. ... A transdermal preparation was approved for use in Japan in January 2006. …

Bromothalonil

Bromothalonil, also known as Methyldibromo glutaronitrile (MDBGN), is a widely used preservative that can be found in many personal hygiene and industrial products. It is also a known allergen and dermatological irritant that has been banned in many EU countries due to increasing rates of contact allergy . In 2005,...
Approved
Experimental

Tirzepatide

Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight control as they demonstrated better glucose control and weight loss compared to selective GLP-1 receptor agonists in preclinical and clinical trials....
Approved
Investigational
Matched Description: … [A246260] Tirzepatide comprises a 39 amino acid linear synthetic peptide conjugated to a C20 fatty ... for the treatment of adults with type 2 diabetes, making it the first and only GIP and GLP-1 receptor ... [L48766] On September 15, 2022, tirzepatide was also approved by the European Commission.[L44386] …

Polyethylene glycol

Polyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage.[A190975,A190978] PEGs are water-soluble polymers that can form hydrogen bonds in a ratio of 100 water molecules per one PEG molecule. Molecular weights of PEGs vary...
Approved
Vet approved
Matched Description: … produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an …
Matched Mixtures name: … Peg-3350, Sodium Sulfate, Sodium Chloride, Potassium Chloride, Sodium Ascorbate and Ascorbic Acid …

Viltolarsen

Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) is characterized by...
Approved
Investigational
Matched Description: … Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of ... A218176] Viltolarsen was granted accelerated FDA approval on August 12, 2020, based on data showing an …

Interferon alfa-n3

Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD).
Approved
Investigational
Matched Categories: … Interferon Type I …

Lorpiprazole

Lorpiprazole is a serotonin antagonist and reuptake inhibitor used for the treatment of major depressive disorder. It is a piperazinyl-triazole derivative.
Approved

Disulfiram

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms...
Approved
Matched Description: … A carbamate derivative used as an alcohol deterrent. …

Pyridoxine

Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of many biological systems within the body. While many plants and microorganisms are...
Approved
Investigational
Nutraceutical
Vet approved
Matched Description: … Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally ... More specifically, pyridoxine is converted to pyridoxal 5-phosphate in the body, which is an important ... and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid …
Matched Mixtures name: … PLASVIT AN INYECTABLE ... New Chapter's D'adamo 4 Your Type Multiple for Type O ... Folic Acid Plus …

Osimertinib

Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing...
Approved
Matched Description: … Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ... (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved ... Furthermore, osimertinib has been shown to spare wild-type EGFR during therapy, thereby reducing non-specific …

Betaine

Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine. It is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and maintaining cell function.[A252235,A252240] Homocystinuria is an inherited disorder that leads to the accumulation of homocysteine in...
Approved
Investigational
Nutraceutical
Matched Description: … [A252235,A252240] Homocystinuria is an inherited disorder that leads to the accumulation of homocysteine ... The FDA and EMA have approved the product Cystadane (betaine anhydrous, oral solution) for the treatment ... of homocystinuria,[L43105,L43115] and the EMA has approved the use of Amversio (betaine anhydrous, oral …
Matched Mixtures name: … Glutamic Acid HCl Betaine HCl W Pepsin ... Glutamic Acid Pepsin and Betaine Tablets …
Matched Categories: … Acid Preparations …

Migalastat

Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). This enzyme is responsible for breaking down glycosphingolipid substrate that, when deficient in patients with Fabry disease, builds up in the blood vessels, the kidneys,...
Approved
Investigational
Matched Description: … ., it is estimated that more than 3,000 people are living with Fabry disease, and an estimated more than ... an oral pharmacological chaperone of alpha-Gal A for the treatment of Fabry disease in adults who have ... [L4274] Migalastat (approved and sold under Amicus Therapeutics' brand name Galafold) is subsequently …

Potassium

Potassium is an essential nutrient, like Calcium and Magnesium. It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans. Many conditions and diseases interfere with normal body potassium balance, and underconsumption of potassium is one example. Hypokalemia (low potassium) or hyperkalemia (high potassium)...
Approved
Experimental
Matched Description: … Potassium is an essential nutrient, like [Calcium] and [Magnesium]. ... They are available in an assortment of tablet, injection, and other forms, depending on the setting and …
Matched Mixtures name: … New Chapter's D'adamo 4 Your Type Multiple for Type O …

Phenformin

A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Approved
Investigational
Withdrawn
Matched Description: … Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis …

Infigratinib

Infigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. By inhibiting the FGFR pathway, which is often aberrated in cancers such as cholangiocarcinoma, infigratinib suppresses tumour growth. Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the second most common primary hepatic malignancy. Infitratinib is a...
Approved
Investigational
Matched Description: … FDA-approved test. ... [A198963] Infitratinib is a pan-FGFR inhibitor, as it is an ATP-competitive inhibitor of all four FGFR ... [L34304] This approval follows [pemigatinib], another FGFR inhibitor approved by the FDA for the same …
Matched Categories: … Receptor, Fibroblast Growth Factor, Type 1, antagonists & inhibitors …

Peginterferon beta-1a

Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of...
Approved
Matched Description: … [L31428] Currently, it is the only approved pegylated interferon for the management of MS with an proven ... It was originally approved by the FDA in 2014 for subcutaneous use, and was approved for intramuscular ... [A176474,L5792] Peginterferon beta-1a is an interferon therapy used for the management of relapsing …
Matched Categories: … Interferon Type I …

Insulin aspart

Insulin aspart is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Description: … Insulin is an important treatment in the management of Type 1 Diabetes (T1D) which is caused by an autoimmune ... with aspartic acid. ... 1 and Type 2 Diabetes. …

Dasatinib

Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the breakpoint cluster region (BCR) gene transcribe the chimeric protein...
Approved
Investigational
Matched Description: … [A2226] The use of dasatinib was first approved by the FDA in 2006.[L45171,L45186] ... Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome …

Fosdenopterin

Molybdenum cofactor deficiency (MoCD) is an exceptionally rare autosomal recessive disorder resulting in a deficiency of three molybdenum-dependent enzymes: sulfite oxidase (SOX), xanthine dehydrogenase, and aldehyde oxidase. Signs and symptoms begin shortly after birth and are caused by a build-up of toxic sulfites resulting from a lack of SOX activity.[A230088,L32163]...
Approved
Matched Description: … in patients with MoCD type A,[L32163] becoming the first and only therapy approved for the treatment ... Molybdenum cofactor deficiency (MoCD) is an exceptionally rare autosomal recessive disorder resulting ... [L43075] In September 2022, the EMA approved the use of fosdenopterin.[L43372,L43433] …
Displaying drugs 276 - 300 of 10941 in total