Identification

Name
Lorpiprazole
Accession Number
DB09195
Type
Small Molecule
Groups
Approved
Description

Lorpiprazole is a serotonin antagonist and reuptake inhibitor used for the treatment of major depressive disorder.[1] It is a piperazinyl-triazole derivative.[3]

Structure
Thumb
Synonyms
Not Available
International/Other Brands
Normarex
Categories
UNII
0M14O7T47Q
CAS number
108785-69-9
Weight
Average: 405.469
Monoisotopic: 405.214030346
Chemical Formula
C21H26F3N5
InChI Key
BNRMWKUVWLKDQJ-YJBOKZPZSA-N
InChI
InChI=1S/C21H26F3N5/c22-21(23,24)16-4-2-5-17(13-16)28-11-9-27(10-12-28)8-7-19-25-26-20-18-6-1-3-15(18)14-29(19)20/h2,4-5,13,15,18H,1,3,6-12,14H2/t15-,18-/m0/s1
IUPAC Name
(1S,8R)-5-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-3,4,6-triazatricyclo[6.3.0.0²,⁶]undeca-2,4-diene
SMILES
[H][C@@]12CCC[C@]1([H])C1=NN=C(CCN3CCN(CC3)C3=CC=CC(=C3)C(F)(F)F)N1C2

Pharmacology

Indication

In 2016, lorpiprazole was classified in the "Chemical structure-related drug-like criteria of global approved drugs" as an antipsychotic and anxiolytic.[6] An antipsychotic is a medication used to treat a state of delusion, hallucination, paranoia or disordered thought. On the other hand, an anxiolytic is a medication used for the treatment of severe, chronic or debilitating anxiety. The anxiety state can be defined as an unpleasant state of tension, apprehension or uneasiness.[4]

Structured Indications
Not Available
Pharmacodynamics

Drugs like lorpiprazole that fit in the category of serotonin antagonists and reuptake inhibitors present a wide variety of effects when administered. They inhibit serotonin receptors like 5-HT2A as well as prevent the reuptake of serotonin, norepinephrine and dopamine. Additionally, they antagonize some adrenergic receptors. This diverse functional profile allows lorpiprazole to have a large therapeutic spectrum from symptom control as an adjuvant of other drugs to control of depressive syndromes as a monotherapy.[2]

Mechanism of action

Lorpiprazole is a serotonin antagonist and reuptake inhibitor thus, its activity is performed by antagonizing the 5-HT2A and the 5-HT2C serotoninergic receptors as well as the alpha1 and alpha2 adrenergic receptors, H1 histaminergic receptors and at high doses, inhibiting the SERT serotonin transporter.[2]

TargetActionsOrganism
A5-hydroxytryptamine receptor 2A
antagonist
Human
A5-hydroxytryptamine receptor 2C
antagonist
Human
AAlpha-1 adrenergic receptors
antagonist
Human
AAlpha-2 adrenergic receptors
antagonist
Human
AHistamine H1 receptor
antagonist
Human
ASodium-dependent serotonin transporter
antagonist
Human
Absorption

After oral administration, the serotonin antagonist and reuptake inhibitors are rapidly absorbed in the gastrointestinal tract. This absorption can be slow down depending on the type of diet. The maximum plasma concentration of this kind of drugs occurs approximately 1 hour after administration.[5]

Volume of distribution

The serotonin antagonists and reuptake inhibitors as lorpiprazole are quickly distributed through the blood-brain-barrier getting concentrated in the brain to even higher levels than the ones found in plasma.[5]

Protein binding

The plasma protein binding of serotonin antagonists and reuptake inhibitors like lorpiprazole is expected to be very high and correspond to even 89-99% of the administered dose.[5]

Metabolism

Serotonin antagonists and reuptake inhibitors like lorpiprazole are metabolized in the liver by the CYP450 isoenzymes, mainly CYP2D6 and CYP3A4.[2]

Route of elimination

The elimination of drugs that fit in the category of serotonin antagonists and reuptake inhibitors like lorpiprazole is expected to have a biphasic profile in which most of the metabolized drug should be disposed of by the urine.[5]

Half life

The estimated half-life for drugs like lorpiprazole, a serotonin antagonist and reuptake inhibitor, is in the range of 11-23 hours.[5]

Clearance
Not Available
Toxicity

The serotonin antagonists and reuptake inhibitors' side effects are minor with rare reports of cardiotoxicity. They have been reported to cause an unbalance between the sympathetic and parasympathetic system. There are also reports regarding a potential hepatotoxic effect of this drugs.[5]

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe serum concentration of 7-Nitroindazole can be increased when it is combined with Lorpiprazole.Experimental
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.Experimental
AbemaciclibThe serum concentration of Abemaciclib can be increased when it is combined with Lorpiprazole.Approved, Investigational
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Lorpiprazole.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Lorpiprazole.Approved, Investigational
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Lorpiprazole.Approved
Acetyl sulfisoxazoleThe metabolism of Lorpiprazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Lorpiprazole.Approved
AdipiplonThe serum concentration of Adipiplon can be increased when it is combined with Lorpiprazole.Investigational
AdrenaloneThe therapeutic efficacy of Adrenalone can be increased when used in combination with Lorpiprazole.Experimental
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Lorpiprazole.Approved
AlcuroniumThe therapeutic efficacy of Alcuronium can be increased when used in combination with Lorpiprazole.Experimental
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Lorpiprazole.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Lorpiprazole.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Lorpiprazole.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Lorpiprazole.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Lorpiprazole.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Lorpiprazole.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Lorpiprazole.Approved, Withdrawn
alpha-Tocopherol acetateThe serum concentration of alpha-Tocopherol acetate can be increased when it is combined with Lorpiprazole.Approved
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Lorpiprazole.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Lorpiprazole.Approved, Investigational
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Lorpiprazole.Illicit, Withdrawn
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Lorpiprazole.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Lorpiprazole.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Lorpiprazole.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Lorpiprazole.Approved
AmitriptylinoxideThe serum concentration of Amitriptylinoxide can be increased when it is combined with Lorpiprazole.Approved, Investigational
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Lorpiprazole.Approved
AmoxapineThe serum concentration of Amoxapine can be increased when it is combined with Lorpiprazole.Approved
AmphetamineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Amphetamine.Approved, Illicit, Investigational
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Lorpiprazole.Approved, Investigational
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Lorpiprazole.Approved, Investigational
ApalutamideThe serum concentration of Apalutamide can be increased when it is combined with Lorpiprazole.Approved, Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Lorpiprazole.Approved
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Lorpiprazole.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Lorpiprazole.Approved, Investigational
ArformoterolThe therapeutic efficacy of Arformoterol can be increased when used in combination with Lorpiprazole.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Lorpiprazole.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Lorpiprazole.Approved
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Lorpiprazole.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Lorpiprazole.Approved, Withdrawn
AsunaprevirThe serum concentration of Asunaprevir can be increased when it is combined with Lorpiprazole.Approved, Investigational, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Lorpiprazole.Approved, Investigational
AtomoxetineThe metabolism of Lorpiprazole can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Lorpiprazole.Approved
AtracuriumThe therapeutic efficacy of Atracurium can be increased when used in combination with Lorpiprazole.Approved, Experimental, Investigational
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Lorpiprazole.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
AZ-002The therapeutic efficacy of AZ-002 can be increased when used in combination with Lorpiprazole.Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Lorpiprazole.Approved
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Lorpiprazole.Approved
BaclofenThe therapeutic efficacy of Baclofen can be increased when used in combination with Lorpiprazole.Approved
BambuterolThe therapeutic efficacy of Bambuterol can be increased when used in combination with Lorpiprazole.Approved, Investigational
BamethanThe therapeutic efficacy of Bamethan can be increased when used in combination with Lorpiprazole.Experimental
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Lorpiprazole.Investigational
BaricitinibThe serum concentration of Baricitinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Lorpiprazole.Approved
BenidipineThe serum concentration of Benidipine can be increased when it is combined with Lorpiprazole.Approved, Investigational
BenmoxinThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Benmoxin.Withdrawn
BenzoctamineThe serum concentration of Benzoctamine can be increased when it is combined with Lorpiprazole.Approved
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Lorpiprazole.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Lorpiprazole.Approved
BetaxololThe metabolism of Lorpiprazole can be decreased when combined with Betaxolol.Approved, Investigational
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Lorpiprazole.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Lorpiprazole.Approved, Investigational
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Lorpiprazole.Approved
BictegravirThe serum concentration of Bictegravir can be increased when it is combined with Lorpiprazole.Approved, Investigational
BioallethrinThe serum concentration of Bioallethrin can be increased when it is combined with Lorpiprazole.Approved, Experimental
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Lorpiprazole.Approved
BitolterolThe therapeutic efficacy of Bitolterol can be increased when used in combination with Lorpiprazole.Withdrawn
BlonanserinThe serum concentration of Blonanserin can be increased when it is combined with Lorpiprazole.Approved, Investigational
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Lorpiprazole.Approved, Withdrawn
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Lorpiprazole.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Lorpiprazole.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Lorpiprazole.Approved
Botulinum Toxin Type AThe therapeutic efficacy of Botulinum Toxin Type A can be increased when used in combination with Lorpiprazole.Approved, Investigational
Botulinum Toxin Type BThe therapeutic efficacy of Botulinum Toxin Type B can be increased when used in combination with Lorpiprazole.Approved, Investigational
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Lorpiprazole.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
BrigatinibThe serum concentration of Brigatinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Lorpiprazole.Approved
BrivaracetamThe serum concentration of Brivaracetam can be increased when it is combined with Lorpiprazole.Approved, Investigational
BrofaromineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Brofaromine.Experimental
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Lorpiprazole.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Lorpiprazole.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Lorpiprazole.Approved
BufuralolThe therapeutic efficacy of Bufuralol can be increased when used in combination with Lorpiprazole.Experimental, Investigational
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Lorpiprazole.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Lorpiprazole.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Lorpiprazole.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Lorpiprazole.Approved, Investigational
ButriptylineThe serum concentration of Butriptyline can be increased when it is combined with Lorpiprazole.Approved
ButyrylthiocholineThe therapeutic efficacy of Butyrylthiocholine can be increased when used in combination with Lorpiprazole.Experimental
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Lorpiprazole.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Lorpiprazole.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Lorpiprazole.Approved
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Lorpiprazole.Approved, Nutraceutical
CamazepamThe serum concentration of Camazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Lorpiprazole.Approved
CannabidiolThe serum concentration of Cannabidiol can be increased when it is combined with Lorpiprazole.Approved, Investigational
CaptodiameThe serum concentration of Captodiame can be increased when it is combined with Lorpiprazole.Approved, Investigational
CarbacholThe therapeutic efficacy of Carbachol can be increased when used in combination with Lorpiprazole.Approved
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Lorpiprazole.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Lorpiprazole.Approved
CarbuterolThe therapeutic efficacy of Carbuterol can be increased when used in combination with Lorpiprazole.Experimental
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Lorpiprazole.Approved, Investigational
CarisoprodolThe therapeutic efficacy of Carisoprodol can be increased when used in combination with Lorpiprazole.Approved
CaroxazoneThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Caroxazone.Withdrawn
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Lorpiprazole.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Lorpiprazole.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Lorpiprazole.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
CeritinibThe serum concentration of Lorpiprazole can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Lorpiprazole.Approved, Withdrawn
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Lorpiprazole.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Lorpiprazole.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational
ChlormezanoneThe serum concentration of Chlormezanone can be increased when it is combined with Lorpiprazole.Approved, Investigational, Withdrawn
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Lorpiprazole.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Lorpiprazole.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Lorpiprazole.Approved, Nutraceutical
CholineThe therapeutic efficacy of Choline can be increased when used in combination with Lorpiprazole.Approved, Nutraceutical
Choline magnesium trisalicylateThe therapeutic efficacy of Choline magnesium trisalicylate can be increased when used in combination with Lorpiprazole.Approved
Choline salicylateThe therapeutic efficacy of Choline salicylate can be increased when used in combination with Lorpiprazole.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Lorpiprazole.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Lorpiprazole.Approved, Investigational
CimetidineThe metabolism of Lorpiprazole can be decreased when combined with Cimetidine.Approved, Investigational
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Lorpiprazole.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Lorpiprazole.Approved, Investigational, Withdrawn
CisatracuriumThe therapeutic efficacy of Cisatracurium can be increased when used in combination with Lorpiprazole.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Lorpiprazole.Approved
CiticolineThe therapeutic efficacy of Citicoline can be increased when used in combination with Lorpiprazole.Approved, Investigational
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Lorpiprazole.Approved
ClemastineThe metabolism of Lorpiprazole can be decreased when combined with Clemastine.Approved, Investigational
ClenbuterolThe therapeutic efficacy of Clenbuterol can be increased when used in combination with Lorpiprazole.Approved, Investigational, Vet Approved
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Lorpiprazole.Approved, Illicit
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Lorpiprazole.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Lorpiprazole.Approved, Investigational
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Lorpiprazole.Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Lorpiprazole.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Lorpiprazole.Approved
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Lorpiprazole.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit
ClotrimazoleThe metabolism of Lorpiprazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
CloxazolamThe serum concentration of Cloxazolam can be increased when it is combined with Lorpiprazole.Approved, Investigational
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Lorpiprazole.Approved
CobicistatThe serum concentration of Lorpiprazole can be increased when it is combined with Cobicistat.Approved
CocaineThe serum concentration of Cocaine can be increased when it is combined with Lorpiprazole.Approved, Illicit
CodeineThe serum concentration of Codeine can be increased when it is combined with Lorpiprazole.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Lorpiprazole.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Lorpiprazole.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be increased when it is combined with Lorpiprazole.Approved
CopanlisibThe serum concentration of Copanlisib can be increased when it is combined with Lorpiprazole.Approved, Investigational
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Lorpiprazole.Approved, Investigational
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Lorpiprazole.Approved
CyamemazineThe serum concentration of Cyamemazine can be increased when it is combined with Lorpiprazole.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Lorpiprazole.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Lorpiprazole.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Lorpiprazole.Approved, Investigational
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Lorpiprazole.Approved, Investigational
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Lorpiprazole.Approved, Investigational
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Lorpiprazole.Approved, Investigational
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Lorpiprazole.Approved
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Lorpiprazole.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Lorpiprazole.Approved, Investigational
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Lorpiprazole.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Lorpiprazole.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Lorpiprazole.Approved
DeanolThe therapeutic efficacy of Deanol can be increased when used in combination with Lorpiprazole.Experimental
DeferasiroxThe serum concentration of Lorpiprazole can be decreased when it is combined with Deferasirox.Approved, Investigational
DeflazacortThe serum concentration of Deflazacort can be increased when it is combined with Lorpiprazole.Approved, Investigational
DelamanidThe serum concentration of Delamanid can be increased when it is combined with Lorpiprazole.Approved, Investigational
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Lorpiprazole.Approved
DelorazepamThe risk or severity of sedation can be increased when Lorpiprazole is combined with Delorazepam.Approved, Illicit, Investigational
DeoxyepinephrineThe therapeutic efficacy of Deoxyepinephrine can be increased when used in combination with Lorpiprazole.Experimental
DeramciclaneThe serum concentration of Deramciclane can be increased when it is combined with Lorpiprazole.Investigational
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Lorpiprazole.Approved, Investigational
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Lorpiprazole.Approved, Investigational
DeutetrabenazineThe serum concentration of Deutetrabenazine can be increased when it is combined with Lorpiprazole.Approved, Investigational
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
Dexchlorpheniramine maleateThe serum concentration of Dexchlorpheniramine maleate can be increased when it is combined with Lorpiprazole.Approved
DexlansoprazoleThe serum concentration of Dexlansoprazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Lorpiprazole.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational, Vet Approved
DibenzepinThe serum concentration of Dibenzepin can be increased when it is combined with Lorpiprazole.Experimental
DichloroisoproterenolThe therapeutic efficacy of Dichloroisoproterenol can be increased when used in combination with Lorpiprazole.Investigational
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Lorpiprazole.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Lorpiprazole.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Lorpiprazole.Approved
Dihydro-alpha-ergocryptineThe serum concentration of Dihydro-alpha-ergocryptine can be increased when it is combined with Lorpiprazole.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Lorpiprazole.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Lorpiprazole.Approved, Investigational
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Lorpiprazole.Approved, Investigational
DimetacrineThe serum concentration of Dimetacrine can be increased when it is combined with Lorpiprazole.Approved, Withdrawn
DimetofrineThe therapeutic efficacy of Dimetofrine can be increased when used in combination with Lorpiprazole.Experimental
DiphenhydramineThe metabolism of Lorpiprazole can be decreased when combined with Diphenhydramine.Approved, Investigational
DipivefrinThe therapeutic efficacy of Dipivefrin can be increased when used in combination with Lorpiprazole.Approved
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Lorpiprazole.Approved
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Lorpiprazole.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Lorpiprazole.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Lorpiprazole.Approved, Investigational
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Lorpiprazole.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Lorpiprazole.Approved
DoramectinThe serum concentration of Doramectin can be increased when it is combined with Lorpiprazole.Vet Approved
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Lorpiprazole.Approved
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Lorpiprazole.Approved
Doxacurium chlorideThe therapeutic efficacy of Doxacurium chloride can be increased when used in combination with Lorpiprazole.Approved
DoxefazepamThe risk or severity of sedation can be increased when Lorpiprazole is combined with Doxefazepam.Experimental
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Lorpiprazole.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Lorpiprazole.Approved, Investigational
DoxycyclineThe metabolism of Lorpiprazole can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Lorpiprazole.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Lorpiprazole.Approved
DroxidopaThe therapeutic efficacy of Droxidopa can be increased when used in combination with Lorpiprazole.Approved, Investigational
DuloxetineThe metabolism of Lorpiprazole can be decreased when combined with Duloxetine.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Lorpiprazole.Approved, Investigational
EdivoxetineThe therapeutic efficacy of Edivoxetine can be increased when used in combination with Lorpiprazole.Investigational
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Lorpiprazole.Approved, Investigational
ElbasvirThe serum concentration of Elbasvir can be increased when it is combined with Lorpiprazole.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Lorpiprazole.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Lorpiprazole.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Lorpiprazole.Approved
EmylcamateThe serum concentration of Emylcamate can be increased when it is combined with Lorpiprazole.Experimental
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
EnasidenibThe serum concentration of Enasidenib can be increased when it is combined with Lorpiprazole.Approved, Investigational
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Lorpiprazole.Approved
EperisoneThe therapeutic efficacy of Eperisone can be increased when used in combination with Lorpiprazole.Approved, Investigational
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Lorpiprazole.Approved, Investigational
EpinephrineThe therapeutic efficacy of Epinephrine can be increased when used in combination with Lorpiprazole.Approved, Vet Approved
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Lorpiprazole.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Lorpiprazole.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Lorpiprazole.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Lorpiprazole.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Lorpiprazole.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Lorpiprazole.Approved, Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Lorpiprazole.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
Estradiol acetateThe serum concentration of Estradiol acetate can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
Estradiol benzoateThe serum concentration of Estradiol benzoate can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
Estradiol cypionateThe serum concentration of Estradiol cypionate can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
Estradiol dienanthateThe serum concentration of Estradiol dienanthate can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
Estradiol valerateThe serum concentration of Estradiol valerate can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Lorpiprazole.Approved, Investigational
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be increased when it is combined with Lorpiprazole.Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Lorpiprazole.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Lorpiprazole.Approved
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Lorpiprazole.Approved, Investigational
EthanolThe serum concentration of Ethanol can be increased when it is combined with Lorpiprazole.Approved
EthanolamineThe therapeutic efficacy of Ethanolamine can be increased when used in combination with Lorpiprazole.Experimental
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lorpiprazole.Approved
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Lorpiprazole.Approved
Ethyl loflazepateThe serum concentration of Ethyl loflazepate can be increased when it is combined with Lorpiprazole.Approved, Illicit
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Lorpiprazole.Approved, Illicit
EtifoxineThe serum concentration of Etifoxine can be increased when it is combined with Lorpiprazole.Investigational, Withdrawn
EtilefrineThe therapeutic efficacy of Etilefrine can be increased when used in combination with Lorpiprazole.Withdrawn
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Lorpiprazole.Approved
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Lorpiprazole.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Lorpiprazole.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Lorpiprazole.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Lorpiprazole.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Lorpiprazole.Approved
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Lorpiprazole.Approved, Investigational
FabomotizoleThe serum concentration of Fabomotizole can be increased when it is combined with Lorpiprazole.Experimental
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Lorpiprazole.Approved, Investigational
Fazadinium bromideThe therapeutic efficacy of Fazadinium bromide can be increased when used in combination with Lorpiprazole.Experimental
FebarbamateThe therapeutic efficacy of Febarbamate can be increased when used in combination with Lorpiprazole.Experimental
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Lorpiprazole.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Lorpiprazole.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Lorpiprazole.Approved
FenoterolThe therapeutic efficacy of Fenoterol can be increased when used in combination with Lorpiprazole.Approved, Investigational
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational, Vet Approved
FenyramidolThe therapeutic efficacy of Fenyramidol can be increased when used in combination with Lorpiprazole.Experimental
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Lorpiprazole.Approved
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Lorpiprazole.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Lorpiprazole.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Lorpiprazole.Approved, Investigational
FluconazoleThe metabolism of Lorpiprazole can be decreased when combined with Fluconazole.Approved, Investigational
FludiazepamThe serum concentration of Fludiazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Lorpiprazole.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Lorpiprazole.Approved, Investigational
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Lorpiprazole.Approved, Investigational
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Lorpiprazole.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Lorpiprazole.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Lorpiprazole.Approved
FluvoxamineThe serum concentration of Fluvoxamine can be increased when it is combined with Lorpiprazole.Approved, Investigational
FormoterolThe therapeutic efficacy of Formoterol can be increased when used in combination with Lorpiprazole.Approved, Investigational
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Lorpiprazole.Approved
FosaprepitantThe serum concentration of Lorpiprazole can be increased when it is combined with Fosaprepitant.Approved
FosnetupitantThe serum concentration of Fosnetupitant can be increased when it is combined with Lorpiprazole.Approved
FosphenytoinThe metabolism of Lorpiprazole can be increased when combined with Fosphenytoin.Approved, Investigational
FostamatinibThe serum concentration of Fostamatinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Lorpiprazole.Approved, Investigational
FurazolidoneThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Furazolidone.Approved, Investigational, Vet Approved
Fusidic AcidThe serum concentration of Lorpiprazole can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabapentinThe serum concentration of Gabapentin can be increased when it is combined with Lorpiprazole.Approved, Investigational
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Lorpiprazole.Approved
GallamineThe therapeutic efficacy of Gallamine can be increased when used in combination with Lorpiprazole.Experimental
GedocarnilThe serum concentration of Gedocarnil can be increased when it is combined with Lorpiprazole.Experimental
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Lorpiprazole.Approved
GepironeThe serum concentration of Gepirone can be increased when it is combined with Lorpiprazole.Investigational
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Lorpiprazole.Approved, Investigational
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Lorpiprazole.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Lorpiprazole.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Lorpiprazole.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Lorpiprazole.Approved, Investigational, Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Lorpiprazole.Approved, Investigational
HalazepamThe serum concentration of Halazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit, Withdrawn
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Lorpiprazole.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Lorpiprazole.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
HarmalineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Harmaline.Experimental
HexafluroniumThe therapeutic efficacy of Hexafluronium can be increased when used in combination with Lorpiprazole.Approved
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Lorpiprazole.Approved
HistamineThe serum concentration of Histamine can be increased when it is combined with Lorpiprazole.Approved, Investigational
HydracarbazineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Hydracarbazine.Experimental
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Lorpiprazole.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Lorpiprazole.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Lorpiprazole.Approved, Investigational
HydroxytyrosolThe therapeutic efficacy of Hydroxytyrosol can be increased when used in combination with Lorpiprazole.Investigational
HydroxyzineThe serum concentration of Hydroxyzine can be increased when it is combined with Lorpiprazole.Approved
IbopamineThe therapeutic efficacy of Ibopamine can be increased when used in combination with Lorpiprazole.Experimental
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Lorpiprazole.Approved
IcotinibThe serum concentration of Icotinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
IdelalisibThe metabolism of Lorpiprazole can be decreased when combined with Idelalisib.Approved
IdrocilamideThe therapeutic efficacy of Idrocilamide can be increased when used in combination with Lorpiprazole.Experimental
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Lorpiprazole.Approved
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Lorpiprazole.Approved
ImagabalinThe serum concentration of Imagabalin can be increased when it is combined with Lorpiprazole.Investigational
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Lorpiprazole.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Lorpiprazole.Approved, Investigational
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Lorpiprazole.Approved
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Lorpiprazole.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Lorpiprazole.Approved
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Lorpiprazole.Approved
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Lorpiprazole.Approved
IpecacThe serum concentration of Ipecac can be increased when it is combined with Lorpiprazole.Approved, Withdrawn
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Lorpiprazole.Approved
IprindoleThe serum concentration of Iprindole can be increased when it is combined with Lorpiprazole.Experimental
IproclozideThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Iproclozide.Withdrawn
IproniazidThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Iproniazid.Withdrawn
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Lorpiprazole.Approved, Investigational
IsavuconazoleThe serum concentration of Isavuconazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Lorpiprazole.Approved, Investigational
IsocarboxazidThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Isocarboxazid.Approved
IsoniazidThe metabolism of Lorpiprazole can be decreased when combined with Isoniazid.Approved, Investigational
IsoprenalineThe therapeutic efficacy of Isoprenaline can be increased when used in combination with Lorpiprazole.Approved, Investigational
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Lorpiprazole.Approved, Investigational
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Lorpiprazole.Approved
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Lorpiprazole.Approved, Investigational
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Lorpiprazole.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Lorpiprazole.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Lorpiprazole.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Lorpiprazole.Approved, Investigational
KetamineThe serum concentration of Ketamine can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Lorpiprazole.Approved
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Lorpiprazole.Approved, Investigational
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
LabetalolThe therapeutic efficacy of Labetalol can be increased when used in combination with Lorpiprazole.Approved
LacidipineThe serum concentration of Lacidipine can be increased when it is combined with Lorpiprazole.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Lorpiprazole.Investigational
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Lorpiprazole.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Lorpiprazole.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Lorpiprazole.Approved, Investigational
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Lorpiprazole.Approved
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Lorpiprazole.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Lorpiprazole.Approved, Investigational
LevonordefrinThe therapeutic efficacy of Levonordefrin can be increased when used in combination with Lorpiprazole.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Lorpiprazole.Approved, Investigational
LevosalbutamolThe therapeutic efficacy of Levosalbutamol can be increased when used in combination with Lorpiprazole.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Lorpiprazole.Approved
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
LisurideThe serum concentration of Lisuride can be increased when it is combined with Lorpiprazole.Approved, Investigational
LofepramineThe serum concentration of Lofepramine can be increased when it is combined with Lorpiprazole.Experimental
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Lorpiprazole.Approved, Investigational
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Lorpiprazole.Approved
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Lorpiprazole.Approved
LoprazolamThe serum concentration of Loprazolam can be increased when it is combined with Lorpiprazole.Experimental
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Lorpiprazole.Approved, Investigational
LorazepamThe serum concentration of Lorazepam can be increased when it is combined with Lorpiprazole.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Lorpiprazole.Approved
LormetazepamThe risk or severity of sedation can be increased when Lorpiprazole is combined with Lormetazepam.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Lorpiprazole.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Lorpiprazole.Approved, Investigational
LuliconazoleThe serum concentration of Lorpiprazole can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Lorpiprazole can be increased when combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Lorpiprazole.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Lorpiprazole.Approved, Investigational
MacimorelinThe serum concentration of Macimorelin can be increased when it is combined with Lorpiprazole.Approved, Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Lorpiprazole.Approved
ManidipineThe metabolism of Lorpiprazole can be decreased when combined with Manidipine.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Lorpiprazole.Approved, Investigational
MebanazineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Mebanazine.Withdrawn
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
MebicarThe serum concentration of Mebicar can be increased when it is combined with Lorpiprazole.Experimental
MebutamateThe serum concentration of Mebutamate can be increased when it is combined with Lorpiprazole.Approved
MedazepamThe serum concentration of Medazepam can be increased when it is combined with Lorpiprazole.Experimental
Medical CannabisThe serum concentration of Medical Cannabis can be increased when it is combined with Lorpiprazole.Experimental, Investigational
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Lorpiprazole.Approved, Investigational
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Lorpiprazole.Approved, Investigational
MelitracenThe serum concentration of Melitracen can be increased when it is combined with Lorpiprazole.Experimental, Investigational
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
MephenesinThe therapeutic efficacy of Mephenesin can be increased when used in combination with Lorpiprazole.Approved
MephenoxaloneThe serum concentration of Mephenoxalone can be increased when it is combined with Lorpiprazole.Experimental
MeprobamateThe serum concentration of Meprobamate can be increased when it is combined with Lorpiprazole.Approved, Illicit
MetaxaloneThe therapeutic efficacy of Metaxalone can be increased when used in combination with Lorpiprazole.Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Lorpiprazole.Approved
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Lorpiprazole.Illicit, Withdrawn
MethocarbamolThe therapeutic efficacy of Methocarbamol can be increased when used in combination with Lorpiprazole.Approved, Vet Approved
MethotrimeprazineThe metabolism of Lorpiprazole can be decreased when combined with Methotrimeprazine.Approved, Investigational
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Lorpiprazole.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
Methylene blueThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Methylene blue.Approved, Investigational
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Lorpiprazole.Approved
MetocurineThe therapeutic efficacy of Metocurine can be increased when used in combination with Lorpiprazole.Approved
MetoprololThe metabolism of Lorpiprazole can be decreased when combined with Metoprolol.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Lorpiprazole.Approved
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Lorpiprazole.Approved, Investigational
MianserinThe serum concentration of Mianserin can be increased when it is combined with Lorpiprazole.Approved, Investigational
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Lorpiprazole.Investigational, Withdrawn
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Lorpiprazole.Approved, Illicit
MidecamycinThe serum concentration of Midecamycin can be increased when it is combined with Lorpiprazole.Approved
MidodrineThe therapeutic efficacy of Midodrine can be increased when used in combination with Lorpiprazole.Approved
MidostaurinThe serum concentration of Midostaurin can be increased when it is combined with Lorpiprazole.Approved, Investigational
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Lorpiprazole.Approved, Investigational
MiltefosineThe therapeutic efficacy of Miltefosine can be increased when used in combination with Lorpiprazole.Approved, Investigational
MinaprineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Minaprine.Approved
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Lorpiprazole.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Lorpiprazole.Approved
MitotaneThe serum concentration of Lorpiprazole can be decreased when it is combined with Mitotane.Approved
MivacuriumThe therapeutic efficacy of Mivacurium can be increased when used in combination with Lorpiprazole.Approved
MoclobemideThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Moclobemide.Approved, Investigational
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Lorpiprazole.Approved, Investigational
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Lorpiprazole.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Lorpiprazole.Approved, Investigational
MRK-409The serum concentration of MRK-409 can be increased when it is combined with Lorpiprazole.Experimental
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Lorpiprazole.Approved, Investigational
N,N,N-Trimethyl-2-(phosphonooxy)ethanaminiumThe therapeutic efficacy of N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium can be increased when used in combination with Lorpiprazole.Experimental
NabiloneThe serum concentration of Nabilone can be increased when it is combined with Lorpiprazole.Approved, Investigational
NabiximolsThe serum concentration of Nabiximols can be increased when it is combined with Lorpiprazole.Approved, Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Lorpiprazole.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Lorpiprazole.Approved, Investigational
NebivololThe therapeutic efficacy of Nebivolol can be increased when used in combination with Lorpiprazole.Approved, Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Lorpiprazole.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Lorpiprazole.Approved
NeratinibThe serum concentration of Neratinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
NetupitantThe serum concentration of Lorpiprazole can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Lorpiprazole.Approved
NialamideThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Nialamide.Withdrawn
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Lorpiprazole.Approved, Investigational
NicotineThe serum concentration of Nicotine can be increased when it is combined with Lorpiprazole.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Lorpiprazole.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Lorpiprazole.Approved, Investigational
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Lorpiprazole.Approved, Investigational
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Lorpiprazole.Approved
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Lorpiprazole.Approved
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Lorpiprazole.Approved, Investigational
NorepinephrineThe therapeutic efficacy of Norepinephrine can be increased when used in combination with Lorpiprazole.Approved
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Lorpiprazole.Approved
NorfenefrineThe therapeutic efficacy of Norfenefrine can be increased when used in combination with Lorpiprazole.Experimental
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Lorpiprazole.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Lorpiprazole.Approved
OctamoxinThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Octamoxin.Withdrawn
OctopamineThe therapeutic efficacy of Octopamine can be increased when used in combination with Lorpiprazole.Experimental
OdanacatibThe serum concentration of Odanacatib can be increased when it is combined with Lorpiprazole.Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Lorpiprazole.Approved
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Lorpiprazole.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Lorpiprazole.Approved
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Lorpiprazole.Investigational
OpiumThe serum concentration of Opium can be increased when it is combined with Lorpiprazole.Approved, Illicit
OrciprenalineThe therapeutic efficacy of Orciprenaline can be increased when used in combination with Lorpiprazole.Approved
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Lorpiprazole.Approved
OsimertinibThe serum concentration of Lorpiprazole can be increased when it is combined with Osimertinib.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Lorpiprazole.Approved, Investigational
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Lorpiprazole.Approved
OxetacaineThe therapeutic efficacy of Oxetacaine can be increased when used in combination with Lorpiprazole.Approved, Investigational
OxilofrineThe therapeutic efficacy of Oxilofrine can be increased when used in combination with Lorpiprazole.Approved
OxprenololThe serum concentration of Oxprenolol can be increased when it is combined with Lorpiprazole.Approved
OxtriphyllineThe therapeutic efficacy of Oxtriphylline can be increased when used in combination with Lorpiprazole.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Lorpiprazole.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Lorpiprazole.Approved, Investigational
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Lorpiprazole.Approved, Investigational
PancuroniumThe therapeutic efficacy of Pancuronium can be increased when used in combination with Lorpiprazole.Approved
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Lorpiprazole.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Lorpiprazole.Approved
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Lorpiprazole.Approved
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Lorpiprazole.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Lorpiprazole.Approved
PargylineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Pargyline.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Lorpiprazole.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Lorpiprazole.Approved, Investigational
ParoxetineThe metabolism of Lorpiprazole can be decreased when combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Lorpiprazole.Approved
Peginterferon alfa-2bThe serum concentration of Lorpiprazole can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Lorpiprazole.Approved, Investigational
PentobarbitalThe metabolism of Lorpiprazole can be increased when combined with Pentobarbital.Approved, Investigational, Vet Approved
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Lorpiprazole.Approved
PergolideThe serum concentration of Pergolide can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Lorpiprazole.Approved, Investigational
PerifosineThe therapeutic efficacy of Perifosine can be increased when used in combination with Lorpiprazole.Investigational
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Lorpiprazole.Approved, Investigational
PerospironeThe serum concentration of Perospirone can be increased when it is combined with Lorpiprazole.Approved
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Lorpiprazole.Approved
PethidineThe serum concentration of Pethidine can be increased when it is combined with Lorpiprazole.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Lorpiprazole.Withdrawn
PhenelzineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Phenelzine.Approved
PheniprazineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Pheniprazine.Withdrawn
PhenobarbitalThe metabolism of Lorpiprazole can be increased when combined with Phenobarbital.Approved, Investigational
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Lorpiprazole.Approved
PhenoxypropazineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Phenoxypropazine.Withdrawn
PhenprobamateThe therapeutic efficacy of Phenprobamate can be increased when used in combination with Lorpiprazole.Experimental
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Lorpiprazole.Approved, Investigational
PhenylephrineThe therapeutic efficacy of Phenylephrine can be increased when used in combination with Lorpiprazole.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
PhosphorylcolamineThe therapeutic efficacy of Phosphorylcolamine can be increased when used in combination with Lorpiprazole.Experimental
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Lorpiprazole.Approved, Investigational
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Lorpiprazole.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Lorpiprazole.Approved
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Lorpiprazole.Approved
PinazepamThe serum concentration of Pinazepam can be increased when it is combined with Lorpiprazole.Experimental
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Lorpiprazole.Approved, Investigational
PipecuroniumThe therapeutic efficacy of Pipecuronium can be increased when used in combination with Lorpiprazole.Approved
PiperaquineThe serum concentration of Piperaquine can be increased when it is combined with Lorpiprazole.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Lorpiprazole.Approved, Investigational
PirbuterolThe therapeutic efficacy of Pirbuterol can be increased when used in combination with Lorpiprazole.Approved
PirlindoleThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Pirlindole.Approved
PitolisantThe serum concentration of Pitolisant can be increased when it is combined with Lorpiprazole.Approved, Investigational
PivhydrazineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Pivhydrazine.Withdrawn
Platelet Activating FactorThe therapeutic efficacy of Platelet Activating Factor can be increased when used in combination with Lorpiprazole.Experimental
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Lorpiprazole.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Lorpiprazole.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be increased when it is combined with Lorpiprazole.Approved, Investigational, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Lorpiprazole.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Lorpiprazole.Approved
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
PregabalinThe serum concentration of Pregabalin can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational
PridinolThe therapeutic efficacy of Pridinol can be increased when used in combination with Lorpiprazole.Experimental
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Lorpiprazole.Approved
PrimidoneThe metabolism of Lorpiprazole can be increased when combined with Primidone.Approved, Vet Approved
ProcarbazineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Procarbazine.Approved, Investigational
ProcaterolThe therapeutic efficacy of Procaterol can be increased when used in combination with Lorpiprazole.Approved, Investigational
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Lorpiprazole.Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Lorpiprazole.Approved
PropiverineThe serum concentration of Propiverine can be increased when it is combined with Lorpiprazole.Approved, Investigational
PropofolThe serum concentration of Propofol can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Lorpiprazole.Approved, Investigational
ProtokylolThe therapeutic efficacy of Protokylol can be increased when used in combination with Lorpiprazole.Approved, Vet Approved
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Lorpiprazole.Approved
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Lorpiprazole.Approved, Investigational
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Lorpiprazole.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Lorpiprazole.Approved
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Lorpiprazole.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Lorpiprazole.Approved, Investigational
QuinineThe serum concentration of Quinine can be increased when it is combined with Lorpiprazole.Approved
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
RacepinephrineThe therapeutic efficacy of Racepinephrine can be increased when used in combination with Lorpiprazole.Approved
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Lorpiprazole.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Lorpiprazole.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Lorpiprazole.Approved, Investigational
RasagilineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Rasagiline.Approved
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Lorpiprazole.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Lorpiprazole.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Lorpiprazole.Approved, Investigational
ReproterolThe therapeutic efficacy of Reproterol can be increased when used in combination with Lorpiprazole.Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Lorpiprazole.Approved
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Lorpiprazole.Approved, Investigational
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Lorpiprazole.Approved
RifapentineThe metabolism of Lorpiprazole can be increased when combined with Rifapentine.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Lorpiprazole.Approved
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Lorpiprazole.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Lorpiprazole.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Lorpiprazole.Approved, Investigational
RitanserinThe serum concentration of Ritanserin can be increased when it is combined with Lorpiprazole.Investigational
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Lorpiprazole.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Lorpiprazole.Approved
RocuroniumThe therapeutic efficacy of Rocuronium can be increased when used in combination with Lorpiprazole.Approved
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Lorpiprazole.Approved, Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Lorpiprazole.Approved, Investigational
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Lorpiprazole.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Lorpiprazole.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Lorpiprazole.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Lorpiprazole.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Lorpiprazole.Approved
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Lorpiprazole.Approved, Investigational, Withdrawn
RucaparibThe serum concentration of Rucaparib can be increased when it is combined with Lorpiprazole.Approved, Investigational
RupatadineThe serum concentration of Rupatadine can be increased when it is combined with Lorpiprazole.Approved
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Lorpiprazole.Approved
SafinamideThe serum concentration of Safinamide can be increased when it is combined with Lorpiprazole.Approved, Investigational
SafrazineThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Safrazine.Withdrawn
SalbutamolThe therapeutic efficacy of Salbutamol can be increased when used in combination with Lorpiprazole.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Lorpiprazole.Approved
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Lorpiprazole.Approved, Investigational
SarilumabThe therapeutic efficacy of Lorpiprazole can be decreased when used in combination with Sarilumab.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Lorpiprazole.Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Lorpiprazole.Approved
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Lorpiprazole.Approved
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Lorpiprazole.Approved, Investigational, Withdrawn
SertralineThe serum concentration of Sertraline can be increased when it is combined with Lorpiprazole.Approved
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Lorpiprazole.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Lorpiprazole.Approved
SiltuximabThe serum concentration of Lorpiprazole can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Lorpiprazole can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Lorpiprazole.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Lorpiprazole.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Lorpiprazole.Approved, Investigational
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Lorpiprazole.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Lorpiprazole.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Lorpiprazole.Approved, Investigational
SotalolThe therapeutic efficacy of Sotalol can be increased when used in combination with Lorpiprazole.Approved
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Lorpiprazole.Approved
St. John's WortThe serum concentration of Lorpiprazole can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StiripentolThe serum concentration of Lorpiprazole can be increased when it is combined with Stiripentol.Approved
StyramateThe therapeutic efficacy of Styramate can be increased when used in combination with Lorpiprazole.Experimental
SuccinylcholineThe therapeutic efficacy of Succinylcholine can be increased when used in combination with Lorpiprazole.Approved
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Lorpiprazole.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Lorpiprazole.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Lorpiprazole.Approved
SulfisoxazoleThe metabolism of Lorpiprazole can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
SynephrineThe therapeutic efficacy of Synephrine can be increased when used in combination with Lorpiprazole.Experimental
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Lorpiprazole.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Lorpiprazole.Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Lorpiprazole.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Lorpiprazole.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Lorpiprazole.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Lorpiprazole.Approved, Investigational
TandospironeThe serum concentration of Tandospirone can be increased when it is combined with Lorpiprazole.Investigational
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Lorpiprazole.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Lorpiprazole.Experimental
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Lorpiprazole.Approved, Withdrawn
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Lorpiprazole.Approved
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Lorpiprazole.Approved, Investigational
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Lorpiprazole.Approved
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Lorpiprazole.Approved
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
TerbutalineThe therapeutic efficacy of Terbutaline can be increased when used in combination with Lorpiprazole.Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Lorpiprazole.Approved, Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Lorpiprazole.Investigational
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Lorpiprazole.Approved, Investigational
Testosterone cypionateThe serum concentration of Testosterone cypionate can be increased when it is combined with Lorpiprazole.Approved
Testosterone enanthateThe serum concentration of Testosterone enanthate can be increased when it is combined with Lorpiprazole.Approved
Testosterone propionateThe serum concentration of Testosterone propionate can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved, Withdrawn
Testosterone undecanoateThe serum concentration of Testosterone undecanoate can be increased when it is combined with Lorpiprazole.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
TetrazepamThe therapeutic efficacy of Tetrazepam can be increased when used in combination with Lorpiprazole.Experimental
TezacaftorThe serum concentration of Tezacaftor can be increased when it is combined with Lorpiprazole.Approved, Investigational
TheodrenalineThe therapeutic efficacy of Theodrenaline can be increased when used in combination with Lorpiprazole.Investigational
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Lorpiprazole.Approved
ThiocolchicosideThe therapeutic efficacy of Thiocolchicoside can be increased when used in combination with Lorpiprazole.Approved, Investigational
ThioridazineThe metabolism of Lorpiprazole can be decreased when combined with Thioridazine.Approved, Withdrawn
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Lorpiprazole.Approved, Investigational
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Lorpiprazole.Approved, Investigational
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Lorpiprazole.Approved, Investigational
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Lorpiprazole.Approved
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Lorpiprazole.Approved
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Lorpiprazole.Approved
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Lorpiprazole.Approved, Investigational
TizanidineThe therapeutic efficacy of Tizanidine can be increased when used in combination with Lorpiprazole.Approved, Investigational
TocilizumabThe serum concentration of Lorpiprazole can be decreased when it is combined with Tocilizumab.Approved
TocofersolanThe serum concentration of Tocofersolan can be increased when it is combined with Lorpiprazole.Approved
TocopherolThe serum concentration of Tocopherol can be increased when it is combined with Lorpiprazole.Approved, Investigational
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Lorpiprazole.Approved, Investigational
TofisopamThe serum concentration of Tofisopam can be increased when it is combined with Lorpiprazole.Approved
ToloxatoneThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Toloxatone.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Lorpiprazole.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Lorpiprazole.Approved
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Lorpiprazole.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Lorpiprazole.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Lorpiprazole.Approved, Investigational
TranylcypromineThe serum concentration of Tranylcypromine can be increased when it is combined with Lorpiprazole.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Lorpiprazole.Approved, Investigational
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Lorpiprazole.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Lorpiprazole.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Lorpiprazole.Approved, Investigational
TrifluoroethanolThe therapeutic efficacy of Trifluoroethanol can be increased when used in combination with Lorpiprazole.Experimental
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Lorpiprazole.Approved
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Lorpiprazole.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Lorpiprazole.Approved
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Lorpiprazole.Investigational, Withdrawn
TrolamineThe therapeutic efficacy of Trolamine can be increased when used in combination with Lorpiprazole.Approved
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Lorpiprazole.Approved
TrolnitrateThe therapeutic efficacy of Trolnitrate can be increased when used in combination with Lorpiprazole.Experimental
TubocurarineThe therapeutic efficacy of Tubocurarine can be increased when used in combination with Lorpiprazole.Approved
TulobuterolThe therapeutic efficacy of Tulobuterol can be increased when used in combination with Lorpiprazole.Investigational
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Lorpiprazole.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Lorpiprazole.Approved
ValbenazineThe serum concentration of Valbenazine can be increased when it is combined with Lorpiprazole.Approved, Investigational
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Lorpiprazole.Approved, Investigational, Withdrawn
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Lorpiprazole.Approved
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Lorpiprazole.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Lorpiprazole.Approved
VecuroniumThe therapeutic efficacy of Vecuronium can be increased when used in combination with Lorpiprazole.Approved
VelpatasvirThe serum concentration of Velpatasvir can be increased when it is combined with Lorpiprazole.Approved, Investigational
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Lorpiprazole.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Lorpiprazole.Approved, Investigational
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Lorpiprazole.Approved
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Lorpiprazole.Approved
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Lorpiprazole.Investigational
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Lorpiprazole.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Lorpiprazole.Approved
ViminolThe therapeutic efficacy of Viminol can be increased when used in combination with Lorpiprazole.Experimental
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Lorpiprazole.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Lorpiprazole.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Lorpiprazole.Approved, Investigational
VinflunineThe serum concentration of Vinflunine can be increased when it is combined with Lorpiprazole.Approved, Investigational
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Lorpiprazole.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Lorpiprazole.Approved, Investigational
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Lorpiprazole.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Lorpiprazole.Approved, Investigational
VoxilaprevirThe serum concentration of Voxilaprevir can be increased when it is combined with Lorpiprazole.Approved, Investigational
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Lorpiprazole.Approved
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Lorpiprazole.Approved, Investigational, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Lorpiprazole.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Lorpiprazole.Approved, Investigational
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Lorpiprazole.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Lorpiprazole.Approved
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Lorpiprazole.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Lorpiprazole.Approved
ZolazepamThe serum concentration of Zolazepam can be increased when it is combined with Lorpiprazole.Vet Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Lorpiprazole.Approved
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Lorpiprazole.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Lorpiprazole.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Lorpiprazole.Approved
ZotepineThe serum concentration of Zotepine can be increased when it is combined with Lorpiprazole.Approved, Investigational, Withdrawn
Food Interactions
Not Available

References

General References
  1. Fagiolini A, Comandini A, Catena Dell'Osso M, Kasper S: Rediscovering trazodone for the treatment of major depressive disorder. CNS Drugs. 2012 Dec;26(12):1033-49. doi: 10.1007/s40263-012-0010-5. [PubMed:23192413]
  2. Jarema M, Dudek D, Landowski J, Heitzman J, Rabe-Jablonska J, Rybakowski J: [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25. [PubMed:22232986]
  3. Elks J. and Ganellin C.R. (1990). The dictionary of drugs. Springer Science.
  4. Clark M., Harvey R., Finkel R., Rey J. and Whalen K. (2011). Pharmacology (5th ed.). Lippincott Williams & Wilkins.
  5. Szyndler J., Skorzewska A. and Plaznik A. (2003). Pharmacotherapy in psychiatry and neurology (3rd ed.). Institute of psychiatry and neurology.
  6. Molecules 2016 [Link]
External Links
PubChem Compound
20055414
PubChem Substance
310265103
ChemSpider
16736802
Wikipedia
Lorpiprazole

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)138 ºCElks J. The Dictionary of Drugs. (1990)
logP3.02DrugCentral
logS-3.63DrugCentral
Predicted Properties
PropertyValueSource
Water Solubility0.095 mg/mLALOGPS
logP3.64ALOGPS
logP3.22ChemAxon
logS-3.6ALOGPS
pKa (Strongest Basic)7.57ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area37.19 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity108.4 m3·mol-1ChemAxon
Polarizability42.08 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Diazinanes
Sub Class
Piperazines
Direct Parent
Phenylpiperazines
Alternative Parents
N-arylpiperazines / Trifluoromethylbenzenes / Dialkylarylamines / Aniline and substituted anilines / N-alkylpiperazines / Aralkylamines / Triazoles / Heteroaromatic compounds / Trialkylamines / Azacyclic compounds
show 4 more
Substituents
Phenylpiperazine / N-arylpiperazine / Trifluoromethylbenzene / Tertiary aliphatic/aromatic amine / Aniline or substituted anilines / Dialkylarylamine / N-alkylpiperazine / Aralkylamine / Monocyclic benzene moiety / Benzenoid
show 16 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Virus receptor activity
Specific Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodop...
Gene Name
HTR2A
Uniprot ID
P28223
Uniprot Name
5-hydroxytryptamine receptor 2A
Molecular Weight
52602.58 Da
References
  1. Jarema M, Dudek D, Landowski J, Heitzman J, Rabe-Jablonska J, Rybakowski J: [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25. [PubMed:22232986]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Serotonin receptor activity
Specific Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-...
Gene Name
HTR2C
Uniprot ID
P28335
Uniprot Name
5-hydroxytryptamine receptor 2C
Molecular Weight
51820.705 Da
References
  1. Jarema M, Dudek D, Landowski J, Heitzman J, Rabe-Jablonska J, Rybakowski J: [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25. [PubMed:22232986]
Kind
Protein group
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Protein heterodimerization activity
Specific Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) prot...

Components:
References
  1. Jarema M, Dudek D, Landowski J, Heitzman J, Rabe-Jablonska J, Rybakowski J: [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25. [PubMed:22232986]
Kind
Protein group
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Thioesterase binding
Specific Function
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazo...

Components:
References
  1. Jarema M, Dudek D, Landowski J, Heitzman J, Rabe-Jablonska J, Rybakowski J: [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25. [PubMed:22232986]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Histamine receptor activity
Specific Function
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamin...
Gene Name
HRH1
Uniprot ID
P35367
Uniprot Name
Histamine H1 receptor
Molecular Weight
55783.61 Da
References
  1. Jarema M, Dudek D, Landowski J, Heitzman J, Rabe-Jablonska J, Rybakowski J: [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25. [PubMed:22232986]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Serotonin:sodium symporter activity
Specific Function
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into t...
Gene Name
SLC6A4
Uniprot ID
P31645
Uniprot Name
Sodium-dependent serotonin transporter
Molecular Weight
70324.165 Da
References
  1. Jarema M, Dudek D, Landowski J, Heitzman J, Rabe-Jablonska J, Rybakowski J: [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25. [PubMed:22232986]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Jarema M, Dudek D, Landowski J, Heitzman J, Rabe-Jablonska J, Rybakowski J: [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25. [PubMed:22232986]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Jarema M, Dudek D, Landowski J, Heitzman J, Rabe-Jablonska J, Rybakowski J: [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25. [PubMed:22232986]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da

Drug created on October 16, 2015 15:28 / Updated on May 01, 2018 23:57