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Displaying drugs 126 - 150 of 10294 in total

Dipyrithione

Dipyrithione, a bactericidal and fungicidal pyrithione derivate, was formulated as Crimanex anti-dandruff shampoo, but is no longer available. It is currently used as a pesticide, and not used in any FDA approved drug products. Interestingly, dipyrithione has been studied and shown to have cytotoxic and potent broad-spectrum antitumor activity, which...
Approved
Matched Description: … [L2611] It is currently used as a pesticide, and not used in any FDA approved drug products. ... to have cytotoxic and potent broad-spectrum antitumor activity, which suggests a potential basis for an ... as [DB06815] and sodium pyrithione, are widely used as cosmetic preservatives and as anti-dandruff agents …

Lapyrium

Lapyrium is a quaternary ammonium cation used as a surfactant, antistatic agent, and biocide in various cosmetic products . It is commonly found formulated as lapyrium chloride.
Approved

Ergometrine

An ergot alkaloid with uterine and vascular smooth muscle contractile properties.
Approved
Matched Description: … An ergot alkaloid with uterine and vascular smooth muscle contractile properties. …
Matched Categories: … Antidepressive Agents ... Serotonin Agents ... Uterotonic agents ... Agents producing tachycardia ... Reproductive Control Agents …

Roxadustat

Roxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that stimulates red blood cell production in response to low oxygen levels. Roxadustat was first approved...
Approved
Investigational
Matched Description: … [A245393] Roxadustat was first approved by the European Commission in August 2021.[L40323] …

N-Cyclohexyl-N'-phenyl-1,4-phenylenediamine

N-Cyclohexyl-N'-phenyl-1,4-phenylenediamine is a component of black rubber. It is also a dermatological sensitizer and allergen. Sensitivity to N-Cyclohexyl-N'-phenyl-1,4-phenylenediamine may be identified with a clinical patch test.
Approved

Dapiprazole

Dapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. It is found in ophthalmic solutions used to reverse mydriasis after an eye examination.
Approved
Matched Description: … Dapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. ... It is found in ophthalmic solutions used to reverse mydriasis after an eye examination. …
Matched Categories: … Adrenergic Agents ... Neurotoxic agents ... Antipsychotic Agents ... Tranquilizing Agents ... Neurotransmitter Agents …

Prednicarbate

Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a...
Approved
Investigational
Matched Description: … It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency …
Matched Categories: … Corticosteroids, Potent (Group III) ... Anti-Inflammatory Agents ... Immunosuppressive Agents …

Capmatinib

Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or overexpression - is known to occur in many...
Approved
Investigational
Matched Description: … [L13347] The presence of the mutation must be confirmed by an FDA-approved test, such as the FoundationOne ... [L13347] Capmatinib was approved by Health Canada on June 8, 2022.[L42015] ... [L13380] As this indication was granted under an accelerated approval, its continued approval is contingent …
Matched Categories: … Antineoplastic Agents ... Antineoplastic and Immunomodulating Agents …

Nefazodone

Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with...
Approved
Withdrawn
Matched Description: … Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb ... Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Triazolopyridine ... Antidepressive Agents, Second-Generation ... Antidepressive Agents Indicated for Depression ... Serotonin Agents …

Lutetium Lu 177 dotatate

A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dotatate may also be referred to as...
Approved
Investigational
Matched Description: … A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of ... Lutetium Lu 177 dotatate was approved by the FDA as Lutathera in January 2018 for intravenous injection ... It is a first radiopharmaceutical agent to be approved for gastroenteropancreatic neuroendocrine tumors …

Angiotensin II

Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and Acute Renal Failure. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy. As of December 21, 2017 the FDA approved La Jolla Pharmaceutical's...
Approved
Investigational
Matched Description: … As of December 21, 2017 the FDA approved La Jolla Pharmaceutical's Giapreza (angiotensin II) Injection …
Matched Categories: … Cardiovascular Agents ... Vasoconstrictor Agents …

Tenofovir alafenamide

Tenofovir alafenamide is a novel tenofovir prodrug developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal...
Approved
Matched Description: … [A178060] Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir ... [T239] Tenofovir alafenamide is an alanine ester form characterized for presenting low systemic levels …
Matched Categories: … Antiviral Agents ... Nephrotoxic agents …

Promazine

A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States.
Approved
Vet approved
Matched Description: … It is currently not approved for use in the United States. ... It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. …
Matched Categories: … Antidepressive Agents ... Autonomic Agents ... Dopamine Agents ... Antipsychotic Agents ... Serotonin Agents …

Ancestim

Ancestim is a non-glycosylated recombinant methionyl human stem cell factor. It is a 166 amino acid protein produced by E. coli with an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine . Ancestim was...
Approved
Investigational
Withdrawn
Matched Description: … [T68] It was also approved by Health Canada in 1999 but it is currently under the status of canceled ... It is a 166 amino acid protein produced by E. coli with an amino acid sequence that is identical to the ... natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

p-tert-Butylphenol-formaldehyde resin (low molecular weight)

p-tert-Butylphenol-formaldehyde resin is a widely used adhesive chemical used in a wide variety of commercially available products and a known dermatological sensitizer and allergen [A34290,A34291]. Sensitivity to p-tert-Butylphenol-formaldehyde resin may be identified with a clinical patch test.
Approved
Experimental

Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine

Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine is used to prevent invasive meningococcal disease, which is caused by bacteria Neisseria meningitidis entering the bloodstream and invading the blood-brain barrier to cause a variety of infections such as septicemia, meningitis, and pneumonia. Several serogroups of N....
Approved
Matched Description: … C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine, marketed as MENVEO, was first approved …

Olaparib

Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Olaparib...
Approved
Matched Description: … [L41100, L40908, L43792] It was first approved by the FDA and EU in December 2014,[A246020] and by Health …
Matched Categories: … Antineoplastic Agents ... Myelosuppressive Agents ... Immunosuppressive Agents ... Antineoplastic and Immunomodulating Agents …

Pemoline

In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons.
Approved
Illicit
Investigational
Withdrawn
Matched Categories: … Central Nervous System Agents ... Psychostimulants, Agents Used for ADHD and Nootropics …

Risperidone

Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone). Schizophrenia and...
Approved
Investigational
Matched Description: … [L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic …
Matched Categories: … Antidepressive Agents ... Dopamine Agents ... Antipsychotic Agents ... Neurotoxic agents ... Serotonin Agents …
Matched Products: … Truemed Group LLC ... RISPERIDONE TEVA GROUP …

Pegfilgrastim

Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, filgrastim. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti-cancer treatment. Although the risk of developing febrile neutropenia...
Approved
Matched Description: … [A187601] The drug is approved for use to decrease the incidence of infection, as manifested by febrile ... [A187607] First developed by Amgen, pegfilgrastim was initially approved by the FDA in 2002 and marketed ... Ziextenzo, Grasustek, Fylnetra, Stimufend) by Health Canada, European Union (EU), and FDA that are approved …
Matched Categories: … Pegylated agents ... Antineoplastic and Immunomodulating Agents …

Venlafaxine

Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, desvenlafaxine, works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and...
Approved
Matched Description: … Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). ... [L43030] The immediate formulation of the drug, marketed as Effexor, was first approved by the FDA in ... Venlafaxine is officially approved to treat major depressive disorder (MDD), generalized anxiety disorder …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Second-Generation ... Antidepressive Agents Indicated for Depression ... Serotonin Agents ... Agents producing tachycardia …

Aprepitant

Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance...
Approved
Investigational
Matched Description: … Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination ... with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting …
Matched Categories: … Autonomic Agents ... Central Nervous System Agents ... Gastrointestinal Agents ... Neurotransmitter Agents ... Peripheral Nervous System Agents …

Cefadroxil

Long-acting, broad-spectrum, water-soluble, cephalexin derivative.
Approved
Vet approved
Withdrawn
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents ... Nephrotoxic agents …

Anthralin

Anthralin (1,8‐dihydroxy‐9anthrone, dithranol) is an older anti-psoriatic agent that was first synthesized as a derivative of chrysarobin, obtained from the araroba tree in Brazil over 100 years ago. Adverse effects of anthralin include irritation and discoloration of the skin . This specific property of the molecule inspired workers to study...
Approved
Matched Description: … Anthralin (1,8‐dihydroxy‐9anthrone, dithranol) is an older anti-psoriatic agent that was first synthesized …

Avatrombopag

Avatrombopag (Doptelet), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require platelet transfusions before surgical procedures to decrease the risk of bleeding. Thrombocytopenia is a...
Approved
Investigational
Matched Description: … Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) ... [F95] Avatrombopag was first approved by the FDA in May 2018 for use in adults with chronic liver …
Displaying drugs 126 - 150 of 10294 in total