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Identification
NamePolymyxin B Sulfate
Accession NumberDB00781  (APRD01190)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.

Structure
Thumb
Synonyms
Polimixina B
Polymyxin B
Polymyxin B Sulphate
Polymyxin-B-Sulfat
Polymyxine B
Polymyxine B (sulfate de)
Polymyxini B sulfas
Polymyxinum B
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Aerosporin Sterile Powderpowder for solution500000 unitintramuscular; inhalation; intrathecal; intravenous; topicalGlaxo Wellcome Inc.1952-12-311998-07-30Canada
Polymyxin B for Injection USPpowder for solution50 mgintramuscular; intrathecal; intravenous; ophthalmicSterimax Inc2012-05-03Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Polymyxin Binjection, powder, for solution500000 [iU]/1intramuscular; intrathecal; intravenous; ophthalmicSagent Pharmaceuticals2011-08-01Not applicableUs
Polymyxin Binjection, powder, lyophilized, for solution500000 [USP'U]/1intramuscular; intrathecal; intravenous; ophthalmicAuro Medics Pharma Llc2016-04-04Not applicableUs
Polymyxin Binjection500000 1/1intramuscular; intrathecal; intravenousXellia Pharmaceuticals Ap S2014-01-24Not applicableUs
Polymyxin Binjection, powder, lyophilized, for solution500000 [USP'U]/1intramuscular; intrathecal; intravenous; ophthalmicFresenius Kabi USA, LLC2015-09-09Not applicableUs
Polymyxin Binjection, powder, lyophilized, for solution500000 [USP'U]/1intramuscular; intrathecal; intravenous; ophthalmicFresenius Kabi USA, LLC2009-11-17Not applicableUs
Polymyxin Binjection, powder, lyophilized, for solution500000 [USP'U]/1intramuscular; intravenousX Gen Pharmaceuticals, Inc.2014-04-25Not applicableUs
Polymyxin Binjection, powder, lyophilized, for solution500000 [USP'U]/1intramuscular; intrathecal; intravenous; ophthalmicX Gen Pharmaceuticals, Inc.2014-01-15Not applicableUs
Polymyxin Binjection, powder, lyophilized, for solution500000 [USP'U]/1intramuscular; intrathecal; intravenous; ophthalmicX Gen Pharmaceuticals, Inc.1994-09-30Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AerosporinGlaxoSmithKline
MetamyxinPola Pharma
Polomyxin BFuji Yakuhin
Poly-RxX-Gen
PolyfaxIntra
PolyxxCelon
Brand mixtures
NameLabellerIngredients
10 Person AnsiGenuine First Aid LLC
25 Person AnsiGenuine First Aid LLC
50 Person AnsiGenuine First Aid LLC
Acme First Aid Contains 404 PiecesAcme United Corp.
Acme Small Cuts and BurnsAcme United Corp.
AerosootheAero Healthcare Us Llc
Ak-poly-bacAkorn, Inc.
American Red Cross First Aid KitTomy International
AntibioticRite Aid Corporation
Antibiotic and Pain ReliefRite Aid Corporation
Antibiotic and Pain Relief Maximum StrengthCVS Pharmacy
Antibiotic CreamPharmetics (2011) Inc
Antibiotic Cream for KidsTaro Pharmaceuticals Inc
Antibiotic Cream Plus Pain ReliefPharmetics (2011) Inc
Antibiotic Cream Plus Pain Relief for KidsCanadian Custom Packaging Company
Antibiotic Ear (neo/polym/hc)Physicians Total Care, Inc.
Antibiotic Maximum StrengthWalgreen Company
Antibiotic OintmentPharmascience Inc
Antibiotic Ointment USPTaro Pharmaceuticals Inc
Antibiotic Original StrengthCVS Pharmacy
Antibiotic Plus Pain ReliefSafeway
Antibiotic Plus Pain Relief CreamTaro Pharmaceuticals Inc
Antibiotic Plus Pain Relief Maximum StrengthRite Aid Corporation
Antibiotique OnguentProdemdis Enr.
Arc First Aid Contains 1000 PiecesAmerican Red Cross
Arc First Aid Contains 404 PiecesAmerican Red Cross
Atopalm First Aid Triple AntibioticNeoPharm Co., Ltd.
Atopalm First Aid Triple Antibiotic Protection Moisturizing and Pain ReliefNeoPharm Co., Ltd.
Bacimyxin OnguentPharmascience Inc
Bacitracin Zinc and Polymyxin B SulfateE. FOUGERA & CO., A division of Nycomed US Inc.
Bacitracin Zinc, Neomycin Sulfate and Polymyxin B SulfateGalentic Pharma (India) Private Limited
Band-aid Brand Adhesive Bandages Plus AntibioticJohnson & Johnson Inc
Band-aid-S-1Johnson & Johnson Inc
Berkley and Jensen Triple AntibioticBJWC
Bioderm OintmentOdan Laboratories Ltd
Biotic-plusProvision Medical
Bp MyxinLaboratoires Sterigen Inc
Budpak Triple Antibiotic Maximum StrengthBudpak Inc.
Cardinal Health First Aid AntibioticCardinal Health
Care One Maximum Strength First Aid AntibioticFoodhold U.S.A. Llc
Careall Triple AntibioticNew World Imports, Inc
Careone Antibiotic Plus Pain ReliefAmerican Sales Company
Careone Original Strength Triple AntibioticFoodhold U.S.A. Llc
Careone Triple AntibioticAmerican Sales Company
Childrens Double Antibiotic With Pain ReliefWalgreen Company
Complete Antibiotic OintmentTaro Pharmaceuticals Inc
CortisporinPhysicians Total Care, Inc.
CortomycinMajor Pharmaceuticals
CuadridermaPro Mex Llc
Cvp Triple AntibioticSalado Sales, Inc
Daymark Fak-35 First AidCmc Group
Dg Health AntibioticDolgencorp Inc
Dg Health Triple AntibioticDolgencorp Inc
Dioptrol OintmentDioptic Pharmaceuticals Inc
Dioptrol SuspensionDioptic Pharmaceuticals Inc
Diosporin OintmentDioptic Pharmaceuticals Inc
Double AntibioticE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
Double Antibiotic Plus Pain Relief Maximum StrengthFred's Inc.
Dr Bells PomadeGenomma Lab Usa Inc.
Dr Teals Triple AntibioticAdvanced Beauty Systems, Inc.
Equaline Antibiotic Plus Pain ReliefSupervalu Inc
Equaline Antibiotic Plus Pain Relief for KidsSupervalu Inc
Equaline First Aid AntibioticSupervalu Inc
Equaline Triple AntibioticSupervalu Inc
Equaline Triple Antibiotic PlusSupervalu Inc
Equate Antibiotic Plus Pain ReliefWal Mart Stores Inc
Exchange Select First Aid Triple Anitbiotic Pain RelievingArmy & Air Force Exchange Service
Exchange Select Triple AntibioticArmy & Air Force Exchange Service
Face Values Triple AntibioticHarmon Stores Inc.
Family Care Triple AntibioticUNITED EXCHANGE CORP.
Family Care Triple Antibiotic Plus Pain ReliefUNITED EXCHANGE CORP.
Family WellnessZhejiang Jingwei Pharmaceutical Co., Ltd.
Family Wellness Triple Antibiotic Plus Pain ReliefFamily Dollar
First Aid AntibioticHy Vee Inc
First Aid Antibiotic OintmentJohnson & Johnson Inc
First Aid Antibiotic Pain Relief Maximum StrengthRite Aid
First Aid Antibiotic Plus Pain Relief Maximum StrengthRite Aid
First Aid Double AntibioticRite Aid
First Aid Pocket Pack - 40 PiecesReady America, Inc.
First Aid Triple AntibioticRite Aid
First Aid Triple Antibiotic and Pain Relief Maximum StrengthLif Elabs, A Division Of Atico International Usa, Inc.
First Aid Triple Antibiotic With Pain RelieverCintas First Aid & Safety
First Aid Value Pack - 77 PiecesReady America, Inc.
Formucare Triple Antibiotic Original StrengthAccess Business Group LLC
Fulton Street Market Triple Antibiotic Original StrengthAccess Business Group LLC
Genuine First Aid - Auto First AidGenuine First Aid, LLC
Genuine First Aid - Home First AidGenuine First Aid, LLC
Genuine First Aid Emergency Preparedness Contains 167 Pieces HardcaseGenuine First Aid LLC
Genuine First Aid Industrial First AidGenuine First Aid, LLC
Genuine Triple AntibioticGenuine First Aid LLC
Gfa First AidGenuine First Aid, LLC
Gfa First Aid 16 Unit Metal CaseGenuine First Aid, LLC
Gfa First Aid 24 Unit Metal CaseGenuine First Aid, LLC
Gfa First Aid 36 Unit Metal CaseGenuine First Aid, LLC
Gfa First Aid Kit Essentials - 33 PiecesGenuine First Aid, LLC
Good Neighbor Pharmacy Antibiotic and Pain ReliefAmerisource Bergen
Good Neighbor Pharmacy Emergency Preparedness and First Aid Contains 167 PiecesAmerisource Bergen
Good Neighbor Pharmacy First AidAmerisource Bergen
Good Neighbor Pharmacy Triple AntibioticAmerisource Bergen
Good Neighbor Pharmacy Triple Antibiotic Plus Pain ReliefAmerisource Bergen
Good Sense First Aid AntibioticL. Perrigo Company
Good Sense Triple AntibioticL Perrigo Company
Good Sense Triple Antibiotic and Pain ReliefL. Perrigo Company
Goodsense Antibiotic Plus Pain ReliefGeiss, Destin & Dunn, Inc.
H E Buddy Antibiotic Maximum Strength Plus Pain ReliefH E B
Healthy Accents Triple AntibioticDZA Brands LLC
JampolycinJamp Pharma Corporation
Kaiser Permanente Double AntibioticKaiser Foundations Hospitals
Lanabiotic OntCombe Incorporated
Leader First Aid AntibioticCardinal Health
Leader Triple AntibioticCardinal Health
Leader Triple Antibiotic PlusCardinal Health
LidomyxinSandoz Canada Incorporated
Lidosporin CreamGlaxo Wellcome Inc.
Lidosporin Ear DropsGlaxo Wellcome Inc.
LincolnLincoln Pharmaceutical Ltd.
Live Better Triple AntibioticThe Great Atlantic & Pacific Tea Company
Live Better Triple Antibiotic Plus Pain ReliefThe Great Atlantic & Pacific Tea Company
Livebetter Antibiotic Plus Pain ReliefThe Great Atlantic & Pacific Tea Company
Lucky Supersoft First AidDelta Brands, Inc
Makesense First AidCherry Hill Sales Co
Market Basket First Aid Triple AntibioticDavion, Inc.
MaxitrolAlcon Laboratories, Inc.
Maxitrol OntAlcon Canada Inc
Medi-firstMedique Products
Medichoice Triple AntibioticOwens & Minor Inc.
Medpride First AidShield Line LLC
Meijer Antibiotic Plus Pain ReliefMeijer Distribution Inc
Meijer Triple AntibioticMeijer Distribution Inc
Meijer Triple Antibiotic PlusMEIJER, INC.
Meijer Triple Antibiotic Plus Pain ReliefMeijer Distribution Inc
MethedexMajor Pharmaceuticals
Mountain Series Weekender MedicalTender Corporation Dba Adventure Medical Kits
Multi Antibiotic With Pain Relief Maximum StrengthWalgreen Company
Neo Bace Ophthalmic OintmentPharmavite Laboratories (1987) Inc.
Neo PolycinPaddock Laboratories, LLC
Neo Polycin HCPaddock Laboratories, LLC
Neo-poly-bacButler Animal Health Supply
Neo-poly-bac HydroButler Animal Health Supply
Neo-poly-dexButler Animal Health Supply
Neo-polycinRebel Distributors Corp
Neo-polycin HCFera Pharmaceuticals
NeocidinMajor Pharmaceuticals
Neomycin and Polymyxin B SulfatesWatson Laboratories, Inc.
Neomycin and Polymyxin B Sulfates and Bacitracin ZincRxv
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc With Hydrocortisone AcetateRebel Distributors Corp
Neomycin and Polymyxin B Sulfates and DexamethasonePaddock Laboratories, LLC
Neomycin and Polymyxin B Sulfates and GramicidinRebel Distributors Corp
Neomycin and Polymyxin B Sulfates and HydrocortisoneBlenheim Pharmacal, Inc
Neomycin and Polymyxin B Sulfates, and Bacitracin ZincHenry Schein Inc.
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and HydrocortisoneMwi/Vet One
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and HydrocortisoneHenry Schein Inc.
Neomycin Polymyxin B Sulfates and DexamethasoneMwi/Vet One
Neomycin Sulfate, Polymyxin B Sulfate and Bacitracin ZincSTAT Rx USA LLC
Neomycin Sulfate, Polymyxin B Sulfate and DexamethasoneSTAT RX LLC USA
Neomycin, Polymyxin B Sulfates and HydrocortisonePhysicians Total Care, Inc.
NeosporinMonarch Pharmaceuticals, Inc.
Neosporin Antibiotic CreamGlaxosmithkline Inc
Neosporin Eye-ear SolutionGlaxosmithkline Inc
Neosporin G.U.Pfizer Laboratories Div Pfizer Inc
Neosporin Irrigating SolutionGlaxosmithkline Inc
Neosporin OintmentGlaxosmithkline Inc
Neosporin Ophthalmic OintmentGlaxosmithkline Inc
Neosporin OriginalJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Neosporin Pain Itch ScarJohnson & Johnson Consumer Inc.
Neosporin Plus Pain ReliefJohnson & Johnson Consumer Inc.
Neosporin Plus Pain Relief First Aid Antibiotic Pain Relieving for KidsJohnson & Johnson Consumer Inc.
Neosporin Plus Pain Relief First Aid Antibiotic/pain RelievingJohnson & Johnson Consumer Inc.
Neosporin Plus Pain Relief Neo To GoJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Neosporin Plus Pain Relief Neo To Go First Aid Antibiotic Pain RelievingJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Neotopic OintmentTechnilab Pharma Inc.
North Triple AntibioticNorth Safety Products
NpdPhoenix Pharmaceutical, Inc.
Odan-sporOdan Laboratories Ltd
Odan-spor-HCOdan Laboratories Ltd
Odan-trolOdan Laboratories Ltd
Onguent AntibiotiqueTherapharma Inc.
Ophthocort OntParke Davis Division, Warner Lambert Canada Inc.
OptimyxinSandoz Canada Incorporated
Optimyxin Ophthalmic OintmentSandoz Canada Incorporated
Optimyxin Plus Oto-opht GtteSandoz Canada Incorporated
Original Antibiotic CreamTaro Pharmaceuticals Inc
Our Family Triple AntibioticNash Finch Company
Ozonol Antibiotic Plus - OintmentBayer Inc Consumer Care
Ozonol Antibiotic Plus OntSterling Winthrop Inc.
Ozonol Antibiotics PlusBayer Inc Consumer Care
Paraid Triple AntibioticMcure Health Solutions Inc.
Pentrexcilina Triple AntibioticOpmx Llc
PMS-polytrimethoprimPharmascience Inc
Polvos De Sulpha First Aid AntibioticMenper Distributors Inc.
Poly AntibioticDolgencorp, LLC
Poly BacitracinPhoenix Global Supply Group, Inc
Polycidin Eye, Ear DropsNovartis Ophthalmics Novartis Pharmaceuticals (Canada) Inc
Polycidin Ophthalmic OintmentNovartis Ophthalmics Novartis Pharmaceuticals (Canada) Inc
PolycinPaddock Laboratories, LLC
Polyderm Antibiotic OintmentPharmetics (2011) Inc
Polyderm Ointment USPTaro Pharmaceuticals Inc
Polymyxin B Sulfate and TrimethoprimSTAT RX LLC USA
Polymyxin B Sulfate and Trimethoprim SulfateMedsource Pharmaceuticals
PolysporinJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Polysporin Antibiotic Burn CreamWarner Lambert Canada Inc.
Polysporin Antibiotic CreamJohnson & Johnson Inc
Polysporin Antibiotic OintmentWarner Lambert Canada Inc.
Polysporin Burn Formula CreamGlaxo Wellcome Inc.
Polysporin Cold Sore OintmentJohnson & Johnson Inc
Polysporin CompleteJohnson & Johnson Inc
Polysporin CreamGlaxo Wellcome Inc.
Polysporin Eye and Ear Drops SterileJohnson & Johnson Inc
Polysporin First Aid AntibioticJohnson & Johnson Consumer Inc.
Polysporin for KidsJohnson & Johnson Inc
Polysporin for StitchesJohnson & Johnson Inc
Polysporin Plus Pain ReliefJohnson & Johnson Inc
Polysporin Plus Pain Relief Ear DropsJohnson & Johnson Inc
Polysporin Sterile Ophthalmic OintmentJohnson & Johnson Inc
Polysporin Topical First Aid Antibiotic OintmentGlaxo Wellcome Inc.
Polysporin Triple Antibiotic OintmentGlaxo Wellcome Inc.
PolytopicSandoz Canada Incorporated
Polytopic CreamSandoz Canada Incorporated
Polytopic OntTechnilab Pharma Inc.
PolytrimAllergan, Inc.
Polytrim Ophthalmic SolutionAllergan Inc
Pomada De LA Campana Triple Antibiotic Pain ReliefGenomma Lab Usa, Inc.
Premier Value Antibiotic Plus Pain ReliefChain Drug Consortium
Premier Value Triple AntibioticChain Drug Consortium
Premier Value Triple Antibiotic PlusTAI GUK PHARM. CO., LTD.
ProcomycinPhysicians Science & Nature Inc.
Procuretriple Antibiotic Triple AntibioticTWIN MED, LLC
Publix AntibioticPublix Super Markets Inc
Publix Antibiotic Plus Pain ReliefPublix Super Markets Inc
Quality Choice Maximum Strength Triple AntibioticChain Drug Marketing Association Inc
Quality Choice Triple AntibioticChain Drug Marketing Association Inc
Quality Choice Triple Antibiotic Plus Pain RelieverChain Drug Marketing Association Inc
Ready America First Aid Outdoor- 107 PiecesGenuine First Aid, LLC
Ready America First Aid Pocket - 33 PiecesGenuine First Aid, LLC
Repara Triple AntibioticPSS World Medical, Inc.
Safeway Antibiotic Plus Pain ReliefSAFEWAY INC
Sandoz CortimyxinSandoz Canada Incorporated
Sandoz PolytrimethoprimSandoz Canada Incorporated
Schein Triple AntibioticHenry Schein, Inc.
Select Medical Products Triple AntibioticPSS World Medical, Inc.
Sheffield Triple AntibioticFaria LLC dba Sheffield Pharmaceuticals
Sheffield Triple Antibiotic Plus Pain ReliefFaria LLC dba Sheffield Pharmaceuticals
Shopko Antibiotic Plus Pain ReliefShopko Stores Operating Co., LLC
Shopko Triple AntibioticShopko Stores Operating Co., LLC
Shopko Triple Antibiotic PlusUNITED EXCHANGE CORP.
Shopko Triple Antibiotic Plus Pain ReliefShopko Stores Operating Co., LLC
Shoprite Triple AntibioticWakefern Food Corporation
Signature Care First Aid AntibioticSafeway
Signature Care Triple AntibioticSafeway
Small Cuts and BurnsGenuine First Aid LLC
Smart Sense Antibiotic Maximum StrengthKmart Corporation
Smart Sense Triple AntibioticKmart Corporation
Smart Sense Triple Antibitotic Plus Pain ReliefKmart Corporation
Sunmark Antibiotic Plus Pain ReliefMc Kesson
Sunmark Double AntibioticMc Kesson
Sunmark Triple AntibioticMc Kesson
Sunmark Triple Antibiotic Plus Pain ReliefMc Kesson
Synalar Bi-otic SolutionMedicis Canada Ltd.
Theraplusplus PlusZhejiang Jingwei Pharmaceutical Co., Ltd.
Topcare Antibiotic Plus Pain ReliefTopco Associates LLC
Topcare Triple AntibioticTopco Associates LLC
Topcare Triple Antibiotic Plus Pain ReliefTopco Associates LLC
Topical Antibiotic OintmentCrls
TribioticHART Health
Tribioticlc Lc LcHART Health
Trimethoprim Sulfate and Polymyxin B SulfateAkorn, Inc.
Triple AntibioticE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
Triple Antibiotic and Pain Relief Maximum StrengthCVS Pharmacy
Triple Antibiotic Extra StrengthPersonal Care Products, Inc.
Triple Antibiotic First AidUniversal Distribution Center LLC
Triple Antibiotic First Aid AntibioticNatureplex LLC
Triple Antibiotic HCPhoenix Pharmaceutical, Inc.
Triple Antibiotic Maximum StrengthBudpak Inc.
Triple Antibiotic OintmentG&W Laboratories, Inc.
Triple Antibiotic PlusG&W Laboratories, Inc.
Triple Antibiotic Plus Maximum StrengthH E B
Triple Antibiotic Plus Pain ReliefMeijer Distribution Inc
Triple Antibiotic Plus Pain Relief Maximum StrengthKroger Company
Triple Antibiotic With Pain Relief Maximum StrengthWalgreen Company
Ultra Seal Triple AntibioticUltra Seal Corporation
Up and Up AntibioticTarget Corporation
Up and Up Antibiotic Plus Pain ReliefTarget Corporation
Up and Up First Aid Antibiotic Pain RelievingTarget Corporation
Wal-sporinWalgreen Company
Walgreens Maximum Strength Triple Antibiotic With Pain ReliefWALGREEN CO.
Walgreens Triple AntibioticWalgreen Company
Walgreenstriple AntibioticWalgreen Company
Water-jel 3-IN-1 AntibioticWater Jel Technologies
Well At Walg Triple Antibiotic Well At WalgreensWalgreens
Western Family Antibiotic Plus Pain ReliefWestern Family Foods Inc
Western Family Triple AntibioticWestern Family Foods Inc
Western Family Triple Antibiotic Plus Pain ReliefWestern Family Foods Inc
Winco Maximum Strength Triple AntibioticWin Co Foods, Llc
Winco Original Strength Triple AntibioticWin Co Foods, Llc
SaltsNot Available
Categories
UNII19371312D4
CAS number1405-20-5
WeightAverage: 1203.4767
Monoisotopic: 1202.749927302
Chemical FormulaC56H98N16O13
InChI KeyInChIKey=WQVJHHACXVLGBL-UHFFFAOYSA-N
InChI
InChI=1S/C56H98N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80)
IUPAC Name
N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide
SMILES
CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC1=O)C(C)O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
KingdomOrganic compounds
Super ClassOrganic Polymers
ClassPolypeptides
Sub ClassNot Available
Direct ParentPolypeptides
Alternative Parents
Substituents
  • Polypeptide
  • Cyclic alpha peptide
  • N-acyl-alpha amino acid or derivatives
  • Macrolactam
  • Alpha-amino acid amide
  • N-substituted-alpha-amino acid
  • Fatty acyl
  • Benzenoid
  • N-acyl-amine
  • Fatty amide
  • Monocyclic benzene moiety
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Lactam
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
PharmacodynamicsPolymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant.
Mechanism of actionPolymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysaccharide of the cytoplasmic outer membrane of Gram-negative bacteria, altering membrane permeability and causing cell death. It does not need to enter the cell.
Related Articles
AbsorptionNot absorbed from the normal alimentary tract.
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationThe drug is excreted slowly by the kidneys.
Half lifeNot Available
ClearanceNot Available
ToxicityOverdose can cause stomach pains, vomiting, and diarrhea.
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.884
Blood Brain Barrier-0.9879
Caco-2 permeable-0.7581
P-glycoprotein substrateSubstrate0.8438
P-glycoprotein inhibitor INon-inhibitor0.8392
P-glycoprotein inhibitor IINon-inhibitor0.8657
Renal organic cation transporterNon-inhibitor0.9411
CYP450 2C9 substrateNon-substrate0.8693
CYP450 2D6 substrateNon-substrate0.7766
CYP450 3A4 substrateNon-substrate0.5151
CYP450 1A2 substrateNon-inhibitor0.9159
CYP450 2C9 inhibitorNon-inhibitor0.9365
CYP450 2D6 inhibitorNon-inhibitor0.9187
CYP450 2C19 inhibitorNon-inhibitor0.9012
CYP450 3A4 inhibitorNon-inhibitor0.6778
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9869
Ames testNon AMES toxic0.8798
CarcinogenicityNon-carcinogens0.8926
BiodegradationNot ready biodegradable0.9829
Rat acute toxicity3.0984 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9788
hERG inhibition (predictor II)Non-inhibitor0.7856
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Glaxosmithkline
  • App pharmaceuticals llc
  • Bedford laboratories div ben venue laboratories inc
  • X gen pharmaceuticals inc
  • Paddock laboratories inc
Packagers
Dosage forms
FormRouteStrength
Kit
Powder for solutionintramuscular; inhalation; intrathecal; intravenous; topical500000 unit
Ointment; padtopical
Suspensiontopical
Suspension/ dropsauricular (otic)
Ointmentophthalmic; topical
Padtopical
Ointmenttopical
Sticktopical
Liquidotic
Ointmentophthalmic
Suspensionophthalmic
Creamtopical
Suspension/ dropsophthalmic
Irrigantirrigation
Solutionirrigation
Solutionauricular (otic)
Solution/ dropsauricular (otic)
Suspensionauricular (otic)
Solutionophthalmic; otic
Solutionurethral
Suspensionotic
Dropsophthalmic; otic
Liquidophthalmic
Powdertopical
Liquidophthalmic; otic
Injectionintramuscular; intrathecal; intravenous500000 1/1
Injection, powder, for solutionintramuscular; intrathecal; intravenous; ophthalmic500000 [iU]/1
Injection, powder, lyophilized, for solutionintramuscular; intrathecal; intravenous; ophthalmic500000 [USP'U]/1
Injection, powder, lyophilized, for solutionintramuscular; intravenous500000 [USP'U]/1
Powder for solutionintramuscular; intrathecal; intravenous; ophthalmic50 mg
Solutionophthalmic
Dropsotic
Solution/ dropsophthalmic
Solutionotic
Prices
Unit descriptionCostUnit
Polymyxin b 100 million unit4039.2USD each
Polymyxin b sulfate vial13.65USD vial
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubility25 mg/mLNot Available
logP-4.861Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0744 mg/mLALOGPS
logP-0.89ALOGPS
logP-7.2ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)11.57ChemAxon
pKa (Strongest Basic)10.23ChemAxon
Physiological Charge5ChemAxon
Hydrogen Acceptor Count18ChemAxon
Hydrogen Donor Count18ChemAxon
Polar Surface Area490.66 Å2ChemAxon
Rotatable Bond Count29ChemAxon
Refractivity313.22 m3·mol-1ChemAxon
Polarizability129.71 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General References
  1. Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. doi: 10.1517/13543784.17.5.661 . [PubMed:18447592 ]
  2. Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. [PubMed:17878146 ]
External Links
ATC CodesA07AA05J01XB02S01AA18S02AA11S03AA03
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (46.3 KB)
Interactions
Drug Interactions
Drug
Atracurium besylatePolymyxin B Sulfate may increase the neuromuscular blocking activities of Atracurium besylate.
BacitracinPolymyxin B Sulfate may increase the nephrotoxic activities of Bacitracin.
CapreomycinCapreomycin may increase the neuromuscular blocking activities of Polymyxin B Sulfate.
Cisatracurium besylatePolymyxin B Sulfate may increase the neuromuscular blocking activities of Cisatracurium besylate.
ColistimethatePolymyxin B Sulfate may increase the neuromuscular blocking activities of Colistimethate.
ColistinPolymyxin B Sulfate may increase the neuromuscular blocking activities of Colistin.
MecamylaminePolymyxin B Sulfate may increase the neuromuscular blocking activities of Mecamylamine.
PancuroniumPolymyxin B Sulfate may increase the neuromuscular blocking activities of Pancuronium.
Picosulfuric acidThe therapeutic efficacy of Sodium picosulfate can be decreased when used in combination with Polymyxin B Sulfate.
RocuroniumPolymyxin B Sulfate may increase the neuromuscular blocking activities of Rocuronium.
SuccinylcholinePolymyxin B Sulfate may increase the neuromuscular blocking activities of Succinylcholine.
VecuroniumPolymyxin B Sulfate may increase the neuromuscular blocking activities of Vecuronium.
Food InteractionsNot Available

Targets

1. Bacterial outer membrane
Kind
Group
Organism
Pharmacological action
yes
Actions
incorporation into and destabilization
References
  1. Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. doi: 10.1517/13543784.17.5.661 . [PubMed:18447592 ]
  2. Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. [PubMed:17878146 ]
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Drug created on June 13, 2005 07:24 / Updated on December 04, 2015 15:10