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Identification
NameCyclobenzaprine
Accession NumberDB00924  (APRD00213)
TypeSmall Molecule
GroupsApproved
Description

Cyclobenzaprine is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Cyclobenzaprine acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. It is structurally similar to Amitriptyline, differing by only one double bond.

Structure
Thumb
Synonyms
(3-Dibenzo[a,d]cyclohepten-5-ylidene-propyl)-dimethyl-amine
Ciclobenzaprina
Cyclobenzaprine
Cyclobenzaprinum
N,N-Dimethyl-5H-dibenzo(a,D)cycloheptene-delta(5,gamma)-propylamine
N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-Δ5,γ-propylamine
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alti-cyclobenzaprine - Tab 10mgtablet10 mgoralAltimed Pharma Inc.1995-12-312005-05-27Canada
Amrixcapsule, extended release15 mg/1oralSTAT Rx USA LLC2007-10-01Not applicableUs
Amrixcapsule, extended release15 mg/1oralPhysicians Total Care, Inc.2009-04-16Not applicableUs
Amrixcapsule, extended release30 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2007-10-01Not applicableUs
Amrixcapsule, extended release15 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-01-03Not applicableUs
Amrixcapsule, extended release30 mg/1oralRebel Distributors Corp2007-10-01Not applicableUs
Amrixcapsule, extended release15 mg/1oralRebel Distributors Corp.2007-10-01Not applicableUs
Amrixcapsule, extended release30 mg/1oralCephalon, Incorporated2007-10-01Not applicableUs
Amrixcapsule, extended release30 mg/1oralSTAT Rx USA LLC2007-10-01Not applicableUs
Amrixcapsule, extended release15 mg/1oralCephalon, Incorporated2007-10-01Not applicableUs
Auro-cyclobenzaprinetablet10 mgoralAuro Pharma Inc2011-06-15Not applicableCanada
Ava-cyclobenzaprinetablet10 mgoralAvanstra Inc2011-10-112014-08-21Canada
Cyclobenzaprinetablet10 mgoralSanis Health Inc2010-02-25Not applicableCanada
Cyclobenzaprinetablet10 mgoralSorres Pharma Inc2009-06-222014-06-20Canada
Cyclobenzaprinetablet10 mgoralSivem Pharmaceuticals Ulc2014-10-01Not applicableCanada
Cyclobenzaprine-10 - Tab 10mgtablet10 mgoralPro Doc Limitee1997-01-15Not applicableCanada
Dom-cyclobenzaprinetablet10 mgoralDominion Pharmacal1998-10-22Not applicableCanada
Flexeril -(10mg)tablet10 mgoralJanssen Inc1978-12-312005-08-04Canada
Jamp-cyclobenzaprinetablet10 mgoralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-cyclobenzaprinetablet10 mgoralJamp Pharma Corporation2011-10-18Not applicableCanada
Mylan-cyclobenzaprinetablet10 mgoralMylan Pharmaceuticals Ulc1997-05-21Not applicableCanada
Novo-cycloprinetablet10 mgoralTeva Canada Limited1994-12-31Not applicableCanada
Nu-cyclobenzaprine-tab 10mgtablet10 mgoralNu Pharm Inc1995-12-312012-09-04Canada
PHL-cyclobenzaprinetablet10 mgoralPharmel Inc2004-04-06Not applicableCanada
PMS-cyclobenzaprine - Tab 10mgtablet10 mgoralPharmascience Inc1996-12-31Not applicableCanada
Q-cyclobenzaprinetablet10 mgoralQd Pharmaceuticals Ulc2012-02-032015-08-21Canada
Ratio-cyclobenzaprinetablet10 mgoralRatiopharm Inc Division Of Teva Canada Limited1997-12-162015-10-26Canada
Riva-cyclobenzaprinetablet10 mgoralLaboratoire Riva Inc2000-05-23Not applicableCanada
Zym-cyclobenzaprinetablet10 mgoralZymcan Pharmaceuticals Inc2012-05-282014-06-16Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-cyclobenzaprine - Tab 10mgtablet10 mgoralApotex Inc1995-12-31Not applicableCanada
Comfort Pac With CyclobenzaprinekitPd Rx Pharmaceuticals, Inc.2013-07-15Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralCamber Pharmaceuticals2012-04-02Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralPharmaceutica North America, Inc.2013-08-07Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralNorthwind Pharmaceuticals, LLC2014-11-24Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralGolden State Medical Supply, Inc.2006-02-03Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralbryant ranch prepack2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralRed Pharm Drug Inc.2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralPreferred Pharmaceuticals, Inc.2015-05-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralMajor Pharmaceuticals1988-02-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralKAISER FOUNDATION HOSPITALS2010-03-02Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralBlenheim Pharmacal, Inc.2010-01-25Not applicableUs
Cyclobenzaprine Hydrochloridetablet7.5 mg/1oralAidarex Pharmaceuticals LLC2011-08-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralMedsource Pharmaceuticals2012-04-02Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralBreckenridge Pharmaceutical, Inc.2006-12-06Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralPhysicians Total Care, Inc.1997-03-17Not applicableUs
Cyclobenzaprine Hydrochloridetablet7.5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralAmerican Health Packaging2009-10-14Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralSolubiomix2015-08-262016-04-05Us
Cyclobenzaprine Hydrochloridetablet5 mg/1oralSTAT Rx USA LLC2010-04-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralPliva Inc.1995-09-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2014-08-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet7.5 mg/1oralProficient Rx LP2011-08-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralAurobindo Pharma Limited2008-09-26Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralCitron Pharma LLC2008-09-26Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralWatson Laboratories, Inc.2006-02-03Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralCamber Pharmaceuticals2012-04-02Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2014-07-31Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/301oralNorthwind Pharmaceuticals2014-05-16Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2006-04-04Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralRanbaxy Pharmaceuticals Inc2008-05-12Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralRed Pharm Drug Inc.2010-07-12Not applicableUs
Cyclobenzaprine Hydrochloridetablet7.5 mg/1oralPreferred Pharmaceuticals, Inc.2012-05-08Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralSTAT Rx USA LLC2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2006-04-04Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-02Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2014-02-06Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralProficient Rx LP2012-03-14Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralKeltman Pharmaceuticals Inc.2010-06-10Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralLiberty Pharmaceuticals, Inc.1989-05-03Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralPd Rx Pharmaceuticals, Inc.2014-07-31Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralMylan Institutional Inc.1997-08-25Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2006-04-06Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralRanbaxy Pharmaceuticals Inc2008-05-12Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralRed Pharm Drug Inc.2007-01-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralPreferred Pharmaceuticals, Inc.2014-02-26Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralPreferred Pharmaceuticals Inc.2016-04-13Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2013-03-13Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralApotheca Inc.2012-04-02Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralLake Erie Medical DBA Quality Care Product LLC2010-07-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2013-05-22Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralProficient Rx LP1989-05-03Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralKeltman Pharmaceuticals Inc.2006-08-24Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralKLE 2, Inc.2011-08-292015-12-29Us
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralMylan Pharmaceuticals Inc.2006-02-03Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralPd Rx Pharmaceuticals, Inc.2006-12-06Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralUnit Dose Services2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralRanbaxy Pharmaceuticals Inc2008-05-12Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralContract Pharmacy Services Pa2010-04-23Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralPreferred Pharmaceuticals, Inc.2015-04-22Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralQualitest Pharmaceuticals2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-04-23Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2012-03-05Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralREMEDYREPACK INC.2013-06-09Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralPd Rx Pharmaceuticals, Inc.2010-05-24Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralReady Meds2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet7.5 mg/1oralDispensing Solutions, Inc.2011-08-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralMylan Pharmaceuticals Inc.2013-04-24Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralKvk Tech, Inc.2014-07-31Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralUnit Dose Services2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralMutual Pharmaceutical1995-05-23Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralNew Horizon Rx Group, LLC2013-08-25Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralProficient Rx LP2015-03-25Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralDispensing Solutions, Inc.1989-05-03Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc.2011-07-07Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralA S Medication Solutions2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralQualitest Pharmaceuticals2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralRebel Distributors2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-04-02Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralREMEDYREPACK INC.2011-04-26Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2013-03-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralCardinal Health2011-07-15Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralDIRECT RX2015-01-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralDispensing Solutions, Inc.2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralMc Kesson Contract Packaging2011-09-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralMylan Pharmaceuticals Inc.1991-05-30Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralKvk Tech, Inc.2014-07-31Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralWatson Laboratories, Inc.1989-05-03Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralRebel Distributors2006-04-19Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralSTAT Rx USA LLC2010-04-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralMutual Pharmaceutical1995-05-23Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralClinical Solutions Wholesale2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralProficient Rx LP2012-04-02Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralMed Vantx, Inc.1995-09-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralLegacy Pharmaceutical Packaging2012-04-02Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralAll Pharma, Llc2015-03-25Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralAidarex Pharmaceuticals LLC2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralNorthwind Pharmaceuticals, LLC2015-03-17Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2014-10-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralbryant ranch prepack2007-02-28Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralAphena Pharma Solutions Tennessee, Llc1989-05-03Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralSa3, Llc2015-03-25Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralBlenheim Pharmacal, Inc.2012-03-30Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralRx Change Co.2014-11-06Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralMedsource Pharmaceuticals2011-08-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2013-02-25Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralPhysicians Total Care, Inc.2006-05-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralDIRECT RX2014-01-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-06-14Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralAmerican Health Packaging2014-05-30Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/10mgoralAlivio Medical Products, Llc2015-10-01Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralKAISER FOUNDATION HOSPITALS2015-11-10Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated5 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralSTAT Rx USA LLC2010-04-29Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralAv Pak2014-06-10Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralAidarex Pharmaceuticals LLC2015-03-25Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralClinical Solutions Wholesale2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet10 mg/1oralProficient Rx LP2010-02-18Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralAurobindo Pharma Limited2008-09-26Not applicableUs
Cyclobenzaprine Hydrochloridetablet5 mg/1oralLegacy Pharmaceutical Packaging2012-04-02Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated10 mg/1oralCitron Pharma LLC2008-09-26Not applicableUs
Cyclobenzaprine Hydrochloridetablet, film coated7.5 mg/1oralWatson Laboratories, Inc.2006-02-03Not applicableUs
Cyclobenzaprine Hydrochloride KitkitPharmaceutica North America, Inc.2013-08-28Not applicableUs
Cyclobenzaprine Hyrochloridetablet7.5 mg/1oralbryant ranch prepack2011-08-29Not applicableUs
Cyclobenzaprine Hyrochloridetablet7.5 mg/1oralRebel Distributors Corp2011-08-29Not applicableUs
Cyclobenzaprine Hyrochloridetablet7.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-08-29Not applicableUs
Cyclobenzaprine Hyrochloridetablet7.5 mg/1oralH.J. Harkins Company, Inc.2011-08-29Not applicableUs
Cyclobenzaprine Hyrochloridetablet7.5 mg/1oralUnit Dose Services2011-08-29Not applicableUs
Fexmidtablet, film coated7.5 mg/1oralVictory Pharma, Inc.2008-11-01Not applicableUs
Fexmidtablet, film coated7.5 mg/1oralShionogi Inc.2011-10-01Not applicableUs
Fexmidtablet, film coated7.5 mg/1oralRebel Distributors Corp2008-11-01Not applicableUs
Fexmidtablet, film coated7.5 mg/1oralSTAT Rx USA LLC2008-11-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
TabradolkitoralFusion Pharmaceuticals LLC2009-09-17Not applicableUs
TabradolkitoralCalifornia Pharmaceuticals, Llc2016-01-01Not applicableUs
International Brands
NameCompany
FlexerilJanssen
FlexibanSIT
Brand mixtures
NameLabellerIngredients
Cyclo/magLiving Well Pharmacy, Inc.
Cyclo/mag 10mg/200mgLiving Well Pharmacy, Inc.
Gapeam BudibacAlvix Laboratories, LLC
Therabenzaprine-60Physician Therapeutics Llc
Therabenzaprine-90Physician Therapeutics Llc
Therabenzaprine-90-5Physician Therapeutics Llc
Salts
Name/CASStructureProperties
Cyclobenzaprine Hydrochloride
6202-23-9
Thumb
  • InChI Key: VXEAYBOGHINOKW-UHFFFAOYSA-N
  • Monoisotopic Mass: 311.144077416
  • Average Mass: 311.848
DBSALT000479
Categories
UNII69O5WQQ5TI
CAS number303-53-7
WeightAverage: 275.3874
Monoisotopic: 275.167399677
Chemical FormulaC20H21N
InChI KeyInChIKey=JURKNVYFZMSNLP-UHFFFAOYSA-N
InChI
InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3
IUPAC Name
dimethyl(3-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-ylidene}propyl)amine
SMILES
CN(C)CCC=C1C2=CC=CC=C2C=CC2=CC=CC=C12
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dibenzocycloheptenes. These are compounds containing a dibenzocycloheptene moiety, which consists of two benzene connected by a cycloheptene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassDibenzocycloheptenes
Sub ClassNot Available
Direct ParentDibenzocycloheptenes
Alternative Parents
Substituents
  • Dibenzocycloheptene
  • Tertiary aliphatic amine
  • Tertiary amine
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Amine
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.
PharmacodynamicsCyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.
Mechanism of actionLike other tricyclic antidepressants, cyclobenzaprine exhibits anticholinergic activity, potentiation of norepinephrine, and antagonism of reserpine. Cyclobenzaprine does not directly act on the neuromuscular junction or the muscle but relieves muscle spasms through a central action, possibly at the brain stem level. Cyclobenzaprine binds to the serotonin receptor and is considered a 5-HT2 receptor antagonist that reduces muscle tone by decreasing the activity of descending serotonergic neurons.
Related Articles
AbsorptionSlowly but well absorbed after oral administration
Volume of distributionNot Available
Protein bindingVery high (93%)
Metabolism

Extensively metabolized (gastrointestinal and hepatic).

SubstrateEnzymesProduct
Cyclobenzaprine
desmethylcyclobenzaprineDetails
Route of eliminationCyclobenzaprine is extensively metabolized, and is excreted primarily as glucuronides via the kidney.
Half life18 hours (range 8-37 hours)
Clearance
  • 0.7 L/min
ToxicityOral mouse and rat LD50 are 338 mg/kg and 425 mg/kg respectively. Signs of overdose include agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low temperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, and vomiting.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9941
Blood Brain Barrier+0.9512
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.7567
P-glycoprotein inhibitor IInhibitor0.8563
P-glycoprotein inhibitor IIInhibitor0.6447
Renal organic cation transporterInhibitor0.7955
CYP450 2C9 substrateNon-substrate0.7826
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7501
CYP450 1A2 substrateInhibitor0.7324
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8933
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9158
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6955
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8127
BiodegradationNot ready biodegradable0.8727
Rat acute toxicity2.9697 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7531
hERG inhibition (predictor II)Inhibitor0.6767
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Anesta ag
  • Actavis totowa llc
  • Aurobindo pharma ltd
  • Cadista pharmaceuticals inc
  • Invagen pharmaceuticals inc
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Orit laboratories llc
  • Pliva inc
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Vintage pharmaceuticals inc
  • Watson laboratories inc
  • Mcneil pediatrics
Packagers
Dosage forms
FormRouteStrength
Capsule, extended releaseoral15 mg/1
Capsule, extended releaseoral30 mg/1
Tabletoral10 mg
Kit
Tabletoral10 mg/1
Tabletoral10 mg/10mg
Tabletoral5 mg/1
Tabletoral7.5 mg/1
Tablet, film coatedoral10 mg/301
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral5 mg/1
Tablet, film coatedoral7.5 mg/1
Kit
Kittopical
Kitoral
Prices
Unit descriptionCostUnit
Cyclobenzaprine hcl crystal273.88USD g
Cyclobenzaprine hcl powder35.84USD g
Fexmid 7.5 mg tablet4.18USD tablet
Flexeril 5 mg tablet2.04USD tablet
Flexeril 10 mg tablet1.74USD tablet
Cyclobenzaprine HCl 5 mg tablet1.71USD tablet
Cyclobenzaprine 5 mg tablet1.64USD tablet
Cyclobenzaprine HCl 10 mg tablet0.47USD tablet
Cyclobenzaprine 10 mg tablet0.41USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7387793 No2005-02-262025-02-26Us
US7544372 No2003-11-142023-11-14Us
US7790199 No2003-11-142023-11-14Us
US7820203 No2003-11-142023-11-14Us
US7829121 No2003-11-142023-11-14Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
boiling point173-177Not Available
water solubilityFreely SolubleNot Available
logP5.2Not Available
pKa8.47Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00689 mg/mLALOGPS
logP4.73ALOGPS
logP4.61ChemAxon
logS-4.6ALOGPS
pKa (Strongest Basic)9.76ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area3.24 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity102.62 m3·mol-1ChemAxon
Polarizability32.95 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Villani, F.J.; US. Patent 3,409,640; November 5,1968; assigned to Schering Corporation.

General ReferencesNot Available
External Links
ATC CodesM03BX08
AHFS Codes
  • 12:20.00
PDB EntriesNot Available
FDA labelDownload (230 KB)
MSDSDownload (73.1 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Cyclobenzaprine can be increased when it is combined with Abiraterone.
AcepromazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Acepromazine.
AcetophenazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Acetophenazine.
AclidiniumAclidinium may increase the anticholinergic activities of Cyclobenzaprine.
AmisulprideThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Amisulpride.
AripiprazoleThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Aripiprazole.
AzelastineCyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Cyclobenzaprine.
BenzquinamideThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Benzquinamide.
BortezomibThe metabolism of Cyclobenzaprine can be decreased when combined with Bortezomib.
Botulinum Toxin Type ACyclobenzaprine may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BCyclobenzaprine may increase the anticholinergic activities of Botulinum Toxin Type B.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
BuprenorphineCyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
CarphenazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Carphenazine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Chlormezanone.
ChlorpromazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Chlorprothixene.
Cimetropium BromideCyclobenzaprine may increase the anticholinergic activities of Cimetropium Bromide.
ClozapineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Clozapine.
DapoxetineThe risk or severity of adverse effects can be increased when Dapoxetine is combined with Cyclobenzaprine.
DeferasiroxThe serum concentration of Cyclobenzaprine can be increased when it is combined with Deferasirox.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
EluxadolineCyclobenzaprine may increase the activities of Eluxadoline.
EthanolCyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
FencamfamineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fencamfamine.
FlupentixolThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fluphenazine.
FluspirileneThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fluspirilene.
FluvoxamineThe metabolism of Cyclobenzaprine can be decreased when combined with Fluvoxamine.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Glucagon recombinant.
GranisetronGranisetron may increase the serotonergic activities of Cyclobenzaprine.
HaloperidolThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Haloperidol.
HydrocodoneCyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Cyclobenzaprine.
IsocarboxazidCyclobenzaprine may increase the serotonergic activities of Isocarboxazid.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Cyclobenzaprine.
LinezolidCyclobenzaprine may increase the serotonergic activities of Linezolid.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cyclobenzaprine.
LoxapineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Loxapine.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
MesoridazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Mesoridazine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Methotrimeprazine.
MetoclopramideThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Metoclopramide.
MetyrosineCyclobenzaprine may increase the sedative activities of Metyrosine.
MexiletineThe metabolism of Cyclobenzaprine can be decreased when combined with Mexiletine.
MianserinMianserin may increase the anticholinergic activities of Cyclobenzaprine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
MirabegronThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Mirabegron.
MoclobemideCyclobenzaprine may increase the serotonergic activities of Moclobemide.
MolindoneThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
OlanzapineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Olanzapine.
OndansetronThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ondansetron.
OrphenadrineCyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
PaliperidoneThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Paliperidone.
ParaldehydeCyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Peginterferon alfa-2bThe serum concentration of Cyclobenzaprine can be increased when it is combined with Peginterferon alfa-2b.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
PerphenazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Perphenazine.
PhenelzineCyclobenzaprine may increase the serotonergic activities of Phenelzine.
PimozideThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Pimozide.
PiperacetazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Piperacetazine.
Potassium ChlorideCyclobenzaprine may increase the ulcerogenic activities of Potassium Chloride.
PramipexoleCyclobenzaprine may increase the sedative activities of Pramipexole.
PramlintidePramlintide may increase the anticholinergic activities of Cyclobenzaprine.
ProcarbazineCyclobenzaprine may increase the serotonergic activities of Procarbazine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Cyclobenzaprine.
PromazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Promazine.
QuetiapineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Quetiapine.
RamosetronCyclobenzaprine may increase the activities of Ramosetron.
RasagilineCyclobenzaprine may increase the serotonergic activities of Rasagiline.
RemoxiprideThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Remoxipride.
ReserpineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Reserpine.
RisperidoneThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Risperidone.
RopiniroleCyclobenzaprine may increase the sedative activities of Ropinirole.
RotigotineCyclobenzaprine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Cyclobenzaprine.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Cyclobenzaprine.
SelegilineCyclobenzaprine may increase the serotonergic activities of Selegiline.
SertindoleThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Sertindole.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Cyclobenzaprine.
SuvorexantCyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Cyclobenzaprine can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
Tedizolid PhosphateCyclobenzaprine may increase the serotonergic activities of Tedizolid Phosphate.
ThalidomideCyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThioridazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Thiothixene.
TiotropiumCyclobenzaprine may increase the anticholinergic activities of Tiotropium.
TopiramateThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Topiramate.
TramadolCyclobenzaprine may increase the neuroexcitatory activities of Tramadol.
TranylcypromineCyclobenzaprine may increase the serotonergic activities of Tranylcypromine.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Cyclobenzaprine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Triflupromazine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Cyclobenzaprine.
VemurafenibThe serum concentration of Cyclobenzaprine can be increased when it is combined with Vemurafenib.
ZiprasidoneThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Ziprasidone.
ZolpidemCyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Zuclopenthixol.
Food Interactions
  • Avoid alcohol.
  • Take with food to reduce irritation.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Virus receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates...
Gene Name:
HTR2A
Uniprot ID:
P28223
Molecular Weight:
52602.58 Da
References
  1. Honda M, Nishida T, Ono H: Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol. 2003 Jan 1;458(1-2):91-9. [PubMed:12498911 ]
  2. Kobayashi H, Hasegawa Y, Ono H: Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol. 1996 Sep 5;311(1):29-35. [PubMed:8884233 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Wang RW, Liu L, Cheng H: Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91. [PubMed:8818577 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Wang RW, Liu L, Cheng H: Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91. [PubMed:8818577 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on July 28, 2016 01:51