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Identification
NameEthinyl Estradiol
Accession NumberDB00977  (APRD00691)
TypeSmall Molecule
GroupsApproved
DescriptionA semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally and is often used as the estrogenic component in oral contraceptives [PubChem]. Ethinyl estradiol is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Tri-Cyclen, Triphasil, and Yasmin. The FDA label includes a black box warning that states that combination oral contraceptives should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.
Structure
Thumb
Synonyms
17 alpha-Ethinylestradiol
17 alpha-Ethynylestradiol
17 alpha-Ethynyloestradiol
17-ethinyl-3,17-estradiol
17-ethinyl-3,17-oestradiol
17-ethinylestradiol
17alpha-Ethinyl estradiol
17α-ethynylestradiol
Ethinyl-Oestranol
Ethinylestradiol
Ethinylestradiolum
Ethinylestriol
Ethinyloestradiol
Ethynyl estradiol
Ethynylestradiol
Ethynyloestradiol
Etinilestradiol
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Estinyl Tab 0.05mgtablet.05 mgoralSchering Plough Canada Inc1951-12-312000-07-11Canada
Estinyl Tab 0.5mgtablet.5 mgoralSchering Plough Canada Inc1951-12-312000-07-11Canada
Estinyl Tablets 0.02 Mg.tablet.02 mgoralSchering Plough Canada Inc1951-12-311998-11-17Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
EstinylSchering
Brand mixtures
NameLabellerIngredients
Alesse 21Pfizer Canada Inc
Alesse 28Pfizer Canada Inc
AltaveraSandoz Inc
Alyacen 1/35Glenmark Pharmaceuticals Inc., Usa
Alyacen 7/7/7Glenmark Pharmaceuticals Inc., Usa
Alysena 21Apotex Inc
Alysena 28Apotex Inc
AmethystWatson Pharma, Inc.
ApriBarr Laboratories Inc.
Apri 21Teva Canada Limited
Apri 28Teva Canada Limited
AranelleBarr Laboratories Inc.
AubraAfaxys Inc.
AvianeBarr Laboratories Inc.
Aviane 21Teva Canada Limited
Aviane 28Teva Canada Limited
Aviane 28 DayRebel Distributors Corp
BalzivaBarr Laboratories Inc.
Blisovi 24 FeLupin Pharmaceuticals, Inc.
Blisovi Fe 1.5/30Lupin Pharmaceuticals, Inc.
Blisovi Fe 1/20Lupin Pharmaceuticals, Inc.
BreviconActavis Pharma, Inc.
Brevicon 0.5/35 21 TabSyntex Inc.
Brevicon 0.5/35 28 TabSyntex Inc.
Brevicon 0.5/35 Tablets (21-day Pack)Pfizer Canada Inc
Brevicon 0.5/35 Tablets (28-day Pack)Pfizer Canada Inc
Brevicon 1/35 21 TabSyntex Inc.
Brevicon 1/35 28 TabSyntex Inc.
Brevicon 1/35 Tablets (21-day Pack)Pfizer Canada Inc
Brevicon 1/35 Tablets (28-day Pack)Pfizer Canada Inc
BriellynGlenmark Pharmaceuticals Inc., Usa
CamreseTeva Pharmaceuticals USA Inc
CamreseloTeva Pharmaceuticals USA Inc
CaziantWatson Pharma, Inc.
Centrisa 21Patriot A Division Of Janssen Inc
Centrisa 28Patriot A Division Of Janssen Inc
Centrisa Lo 21Patriot A Division Of Janssen Inc
Centrisa Lo 28Patriot A Division Of Janssen Inc
ChatealAfaxys Inc.
Cléo -35Aspri Pharma Canada Inc
CryselleBarr Laboratories Inc.
Cyclafem 1/35Qualitest Pharmaceuticals
Cyclafem 7/7/7Qualitest Pharmaceuticals
Cyclen Tablets (21 Day)Janssen Inc
Cyclen Tablets (28 Day)Janssen Inc
CyclessaOrganon USA Inc.
Cyestra-35Paladin Labs Inc
CyredAfaxys Inc.
Dasetta 1/35Northstar Rx LLC
Dasetta 7/7/7Northstar Rx LLC
DayseeLupin Pharmaceuticals, Inc.
DelylaOhm Laboratories Inc.
Demulen 30 (21 Day Pack)Pfizer Canada Inc
Demulen 30 (28 Day Pack)Pfizer Canada Inc
Demulen 50 (21 Day Pack)Pfizer Canada Inc
Demulen 50 (28 Day Pack)Pfizer Canada Inc
DesogenOrganon USA Inc.
Desogestrel and Ethinyl EstradiolNorthstar Rx LLC
Diane-35Bayer Inc
Drospirenone and Ethinyl EstradiolMylan Pharmaceuticals Inc.
Drospirenone and Ethinyl Estradiol Tablets 21Famy Care Ltd
Drospirenone and Ethinyl Estradiol Tablets 28Famy Care Ltd
Drospirenone and Ethinyl Estradiol Tablets USP (21-day Regimen)Glenmark Pharmaceuticals Canada Inc.
Drospirenone and Ethinyl Estradiol Tablets USP (28-day Regimen)Glenmark Pharmaceuticals Canada Inc.
ElinestNorthstar Rx LLC
EmoquetteQualitest Pharmaceuticals
EnpresseBarr Laboratories Inc.
EnskyceLupin Pharmaceuticals, Inc.
Esme 21Mylan Pharmaceuticals Ulc
Esme 28Mylan Pharmaceuticals Ulc
EstaryllaSandoz Inc
Evra -(6/0.60)Janssen Inc
Evra -(6/0.75)Janssen Inc
FalessaAvion Pharmaceuticals, Llc
FalminaNorthstar Rx LLC
Femcon FeWarner Chilcott (US), LLC
FemhrtWarner Chilcott (US), LLC
Freya 21Mylan Pharmaceuticals Ulc
Freya 28Mylan Pharmaceuticals Ulc
FyavolvLupin Pharmaceuticals, Inc.
GeneressActavis Specialty Pharmaceuticals Co
GianviTeva Pharmaceuticals USA Inc
GildagiaQualitest Pharmaceuticals
Gildess 1.5/30Qualitest Pharmaceuticals
Gildess 1/20Qualitest Pharmaceuticals
IndayoMylan Pharmaceuticals Ulc
IntrovaleSandoz Inc
Jevantique LoActavis Pharma, Inc.
JinteliTeva Pharmaceuticals USA Inc
JolessaPhysicians Total Care, Inc.
JuleberNorthstar Rx LLC
Junel 1.5/30Barr Laboratories Inc.
Junel 1/20Barr Laboratories Inc.
Junel Fe 1.5/30Barr Laboratories Inc.
Junel Fe 1/20Barr Laboratories Inc.
Junel Fe 24Teva Pharmaceuticals USA Inc
Kaitlib FeLupin Pharmaceuticals, Inc.
Kelnor 1/35Barr Laboratories Inc.
KimidessQualitest Pharmaceuticals
KurveloLupin Pharmaceuticals, Inc.
LeenaActavis Pharma, Inc.
LessinaBarr Laboratories Inc.
LevonestNorthstar Rx LLC
Levonorgestrel and Ethinyl EstradiolMylan Pharmaceuticals Inc.
Levonorgestrel and Ethinyl Estradiol and Ethinyl EstradiolLupin Pharmaceuticals, Inc.
Levonorgestrel and Ethinyl Estradiol Tablets, 0.1 Mg/0.02 mgLUPIN LIMITED
LevoraRebel Distributors Corp
Linessa 21Aspen Pharma Trading Limited
Linessa 28Aspen Pharma Trading Limited
Lo Loestrin FeWarner Chilcott (US), LLC
Lo Minastrin FeWarner Chilcott (US), LLC
Lo-femenal 21 TabletsPfizer Canada Inc
Lo/ovral-28A S Medication Solutions Llc
Loestrin 1.5/30Warner Chilcott Canada Co
Loestrin 1.5/30 21 DayTeva Women's Health, Inc.
Loestrin 1/20 21 DayTeva Women's Health, Inc.
Loestrin 21 1.5/30 21 DayTeva Women's Health, Inc.
Loestrin 21 1/20 21 DayTeva Women's Health, Inc.
Loestrin 24 FeWarner Chilcott (US), LLC
LoloWarner Chilcott Canada Co
Lomedia 24 FeAmneal Pharmaceuticals of New York, LLC
LorynaSandoz Inc
Low-ogestrelWatson Pharma, Inc.
LuteraWatson Pharma, Inc.
Lutera 21Cobalt Pharmaceuticals Company
Lutera 28Cobalt Pharmaceuticals Company
Marfem 21Novopharm Limited
Marfem 28Novopharm Limited
MarlissaGlenmark Pharmaceuticals Inc., Usa
Marvelon 21Merck Canada Inc
Marvelon 28Merck Canada Inc
MicrogestinActavis Pharma, Inc.
Min-ovral 21Pfizer Canada Inc
Min-ovral 21 TabWyeth Ltd.
Min-ovral 28Pfizer Canada Inc
Min-ovral 28 TabWyeth Ltd.
Minastrin 24 FeWarner Chilcott (US), LLC
Minestrin 1/20Warner Chilcott Canada Co
Mirvala 21Apotex Inc
Mirvala 28Apotex Inc
ModiconJanssen Pharmaceuticals, Inc.
Mono-linyahNorthstar Rx LLC
MononessaActavis Pharma, Inc
MyaApotex Inc
MyzilraQualitest Pharmaceuticals
NeconRebel Distributors Corp
Necon 1/35Watson Pharma, Inc.
Necon 777Actavis Pharma, Inc.
Necon 777 777Dispensing Solutions, Inc.
NikkiLupin Pharmaceuticals, Inc.
Norethindrone Acetate and Ethinyl EstradiolMylan Pharmaceuticals Inc.
Norethindrone and Ethinyl Estradiol and Ferrous FumarateLupin Pharmaceuticals, Inc.
Norgestimate and Ethinyl EstradiolMylan Pharmaceuticals Inc.
NorinylActavis Pharma, Inc.
Nortrel (21 Day Regimen)Barr Laboratories Inc.
Nortrel (28 Day Regimen)Barr Laboratories Inc.
Nortrel 7/7/7 (28 Day Regimen)Barr Laboratories Inc.
Novo-cyproterone/ethinyl EstradiolTeva Canada Limited
NuvaringOrganon USA Inc.
OcellaBarr Laboratories, Inc.
OrsythiaQualitest Pharmaceuticals
Ortho 0.5/35 Tablets (21 Day)Janssen Inc
Ortho 0.5/35 Tablets (28 Day)Janssen Inc
Ortho 1/35 Tablets (21 Day)Janssen Inc
Ortho 1/35 Tablets (28 Day)Janssen Inc
Ortho 10/11 Tablets (21 Day)Janssen Inc
Ortho 10/11 Tablets (28 Day)Janssen Inc
Ortho 7/7/7 Tablets (21 Day)Janssen Inc
Ortho 7/7/7 Tablets (28 Day)Janssen Inc
Ortho CeptJanssen Pharmaceuticals, Inc.
Ortho CyclenJanssen Pharmaceuticals, Inc.
Ortho EvraJanssen Pharmaceutical, Inc.
Ortho Novum 135Janssen Pharmaceuticals, Inc.
Ortho Tri CyclenJanssen Pharmaceuticals, Inc.
Ortho Tri Cyclen LoJanssen Pharmaceuticals, Inc.
Ortho-cept Tablets (21 Day)Janssen Inc
Ortho-cept Tablets (28 Day)Janssen Inc
Ortho-novum 777A S Medication Solutions Llc
Ovcon 35Warner Chilcott (US), LLC
Ovima 21Apotex Inc
Ovima 28Apotex Inc
Ovral 21Pfizer Canada Inc
Ovral 21 TabWyeth Ltd.
Ovral 28 TabletsWyeth Canada
Ovral 28tabWyeth Ltd.
Pirmella 1/35Lupin Pharmaceuticals, Inc.
Pirmella 7/7/7Lupin Pharmaceuticals, Inc.
PortiaBarr Laboratories Inc.
Portia 21Teva Canada Limited
Portia 28Teva Canada Limited
Preven Emergency ContraceptiveGynÉtics Ltd/LtÉe
Preven TabletsShire Pharma Canada Ulc
PrevifemQualitest Pharmaceuticals
Previfem (21day)Novopharm Limited
Previfem (28day)Novopharm Limited
Qismette 21LUPIN LIMITED
Qismette 28LUPIN LIMITED
QuasenseWatson Pharma, Inc.
Ran-cyproterone/ethinyl EstradiolRanbaxy Pharmaceuticals Canada Inc.
ReclipsenWatson Pharma, Inc.
Reclipsen 21Actavis Pharma Company
Reclipsen 28Actavis Pharma Company
Sarensis 21Patriot A Division Of Janssen Inc
Sarensis 28Patriot A Division Of Janssen Inc
SeasonaleTeva Women's Health Inc
SeasoniqueTeva Women's Health Inc
Select 1/35 (21-day)Pfizer Canada Inc
Select 1/35 (28-day)Pfizer Canada Inc
SetlakinNorthstar Rx LLC
SprintecBarr Laboratories Inc.
SronyxWatson Pharma, Inc.
SyedaSandoz Inc
Synphasic 21 TabletsPfizer Canada Inc
Synphasic 28 TabletsPfizer Canada Inc
Synphasic-28 TabletsSyntex Inc.
Tarina Fe 1/20Afaxys Inc.
Tilia FeRebel Distributors Corp
Tri-cyclen Lo (-21 Day)Janssen Inc
Tri-cyclen Lo (28 Day)Janssen Inc
Tri-cyclen Tablets - 21-dayJanssen Inc
Tri-cyclen Tablets - 28-dayJanssen Inc
Tri-estaryllaSandoz Inc
Tri-legest Fe 28 DayBarr Laboratories Inc.
Tri-lena 21Actavis Pharma Company
Tri-lena 28Actavis Pharma Company
Tri-lena Lo 21Actavis Pharma Company
Tri-lena Lo 28Actavis Pharma Company
Tri-linyahNorthstar Rx LLC
Tri-LO- EstaryllaSandoz Inc
Tri-LO-marziaLupin Pharmaceuticals, Inc.
Tri-LO-sprintecTeva Pharmaceuticals USA Inc
Tri-norinylActavis Pharma, Inc.
Tri-previfemQualitest Pharmaceuticals
Tri-previfem (21 Day)Novopharm Limited
Tri-previfem (28 Day)Novopharm Limited
Tri-sprintecBarr Laboratories Inc.
Tricira LoApotex Inc
TrinessaRebel Distributors Corp
Trinessa LoActavis Pharma, Inc.
Triphasil 21Wyeth Canada
Triphasil 21 TabWyeth Ltd.
Triphasil 28Wyeth Canada
Triphasil 28 TabWyeth Ltd.
Triquilar 21Bayer Inc
Triquilar 28Bayer Inc
Velivet Triphasic RegimenBarr Laboratories Inc.
VesturaWatson Pharma, Inc.
Vienva TmSandoz Inc
VyfemlaLupin Pharmaceuticals, Inc.
WeraNorthstar Rx LLC
Wymzya FeLupin Pharmaceuticals, Inc.
XulaneMylan Pharmaceuticals Inc.
YasminBayer Health Care Pharmaceuticals Inc.
Yasmin 21Bayer Inc
Yasmin 28Bayer Inc
Yasmin PlusBayer Inc
YazBayer Health Care Pharmaceuticals Inc.
Yaz PlusBayer Inc
Zamine 21Apotex Inc
Zamine 28Apotex Inc
ZarahWatson Pharma, Inc.
Zarah 21Cobalt Pharmaceuticals Company
Zarah 28Cobalt Pharmaceuticals Company
ZenchentWatson Pharma, Inc.
Zenchent FeWatson Pharma, Inc.
ZeosaTeva Pharmaceuticals USA Inc
Zovia 1/35e-28Actavis Pharma, Inc.
Zovia 1/50e-28Actavis Pharma, Inc.
SaltsNot Available
Categories
UNII423D2T571U
CAS number57-63-6
WeightAverage: 296.4034
Monoisotopic: 296.177630012
Chemical FormulaC20H24O2
InChI KeyInChIKey=BFPYWIDHMRZLRN-RHKZOZTBNA-N
InChI
InChI=1/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/s2
IUPAC Name
(1S,10R,11S,14R,15S)-14-ethynyl-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-triene-5,14-diol
SMILES
[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassEstrane steroids
Direct ParentEstrogens and derivatives
Alternative Parents
Substituents
  • Estrogen-skeleton
  • 17-hydroxysteroid
  • Hydroxysteroid
  • 3-hydroxysteroid
  • Phenanthrene
  • Tetralin
  • Benzenoid
  • Ynone
  • Tertiary alcohol
  • Cyclic alcohol
  • Hydrocarbon derivative
  • Organooxygen compound
  • Alcohol
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.
PharmacodynamicsEthinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl estradiol and norethindrone are used together as an oral contraceptive agent.
Mechanism of actionEstrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
Related Articles
AbsorptionRapid and complete absorption follows oral intake of ethinyl estradiol (bioavailability 43%).
Volume of distributionNot Available
Protein binding97%
Metabolism

Hepatic. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens.

SubstrateEnzymesProduct
Ethinyl Estradiol
2β-OH-17β-ethinylestradiolDetails
Route of eliminationNot Available
Half life36 +/- 13 hours
ClearanceNot Available
ToxicityOral, mouse LD50: 1737 mg/kg. Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. The FDA label includes a black box warning that states that combination oral contraceptives with ethinyl estradiol should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9965
Blood Brain Barrier+0.8546
Caco-2 permeable+0.8638
P-glycoprotein substrateSubstrate0.6892
P-glycoprotein inhibitor INon-inhibitor0.9006
P-glycoprotein inhibitor IINon-inhibitor0.9449
Renal organic cation transporterNon-inhibitor0.84
CYP450 2C9 substrateNon-substrate0.7178
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.715
CYP450 1A2 substrateInhibitor0.8941
CYP450 2C9 inhibitorNon-inhibitor0.9186
CYP450 2D6 inhibitorNon-inhibitor0.9506
CYP450 2C19 inhibitorNon-inhibitor0.6641
CYP450 3A4 inhibitorInhibitor0.5224
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6776
Ames testNon AMES toxic0.9155
CarcinogenicityNon-carcinogens0.8519
BiodegradationNot ready biodegradable0.9879
Rat acute toxicity2.4584 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8805
hERG inhibition (predictor II)Inhibitor0.5788
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Schering corp sub schering plough corp
  • Pharmacia and upjohn co
  • Organon usa inc
Packagers
Dosage forms
FormRouteStrength
Kit
Tabletoral.05 mg
Tabletoral.5 mg
Tabletoral.02 mg
Patch (extended release)transdermal
Tablet (chewable)oral
Tablet, film coatedoral
Tabletoral
Insert, extended releasevaginal
Ring (slow-release)vaginal
Kitoral
Patch, extended releasetransdermal
Patchtransdermal
Prices
Unit descriptionCostUnit
Ethinyl estradiol powder140.0USD g
Ortho-Cyclen (28) 28 0.25-35 mg-mcg tablet Disp Pack38.99USD disp
Ortho tri-cyclen lo tablet2.68USD tablet
Ortho-cyclen 28 tablet1.13USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5798338 No1995-07-102015-07-10Us
US5876746 No1995-11-202015-11-20Us
US5898032 No1997-06-232017-06-23Us
US5989581 No1998-04-082018-04-08Us
US6156742 No2000-12-052020-12-05Us
US6214815 Yes1999-12-092019-12-09Us
US6441168 No2002-07-302022-07-30Us
US6500814 No1998-09-032018-09-03Us
US6652880 No2000-03-292020-03-29Us
US6667050 No1999-04-062019-04-06Us
US6787531 No2000-08-312020-08-31Us
US6933395 No1997-08-112017-08-11Us
US6958326 No2001-12-202021-12-20Us
US6987101 No1997-12-222017-12-22Us
US7163931 No2001-12-202021-12-20Us
US7320969 No2004-01-302024-01-30Us
US7615545 No2003-06-152023-06-15Us
US7704984 No2009-02-022029-02-02Us
US7855190 No2008-12-052028-12-05Us
US7858605 No2003-06-232023-06-23Us
US8415332 No2009-03-112029-03-11Us
US8450299 No2005-10-072025-10-07Us
US8617597 No2010-02-082030-02-08Us
USRE39861 No1997-06-232017-06-23Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point142-144Inhoffen, H.H. and Hohlweg, W.; U.S. Patent 2,265,976; December 9, 1941; assigned to Schering Corp.
water solubility11.3 mg/L (at 27 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP3.67HANSCH,C ET AL. (1995)
logS-4.3ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.00677 mg/mLALOGPS
logP3.63ALOGPS
logP3.9ChemAxon
logS-4.6ALOGPS
pKa (Strongest Acidic)10.33ChemAxon
pKa (Strongest Basic)-1.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area40.46 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity87.37 m3·mol-1ChemAxon
Polarizability34.53 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (9.42 KB)
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-000b-0290000000-0ef72fb5e00440b9ff50View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-000i-0960000000-945d82a0ab94f246ac88View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-056s-2910000000-0d38daebb87a39304e91View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-80) , Positivesplash10-03di-0890000000-7a166e952207cf7bc1d3View in MoNA
MSMass Spectrum (Electron Ionization)splash10-03dj-2980000000-831c8190c59f98fc8623View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Andreas Sachse, “Method of female hormonal contraception using a fixed extended cycle hormonal preparation containing dienogest and ethinyl estradiol.” U.S. Patent US20060079491, issued April 13, 2006.

US20060079491
General ReferencesNot Available
External Links
ATC CodesG03AA03G03AA04G03AB07G03AA08G03AA10G03AB05G03AA09G03AB01G03AA11G03AB03G03CA01L02AA03G03AB02G03AA01G03AA16G03AA06G03AA02G03AA05G03AA12G03AA07G03AA15G03AA13G03AB06G03AB04
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (470 KB)
MSDSDownload (73.9 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Ethinyl Estradiol.
AbciximabEthinyl Estradiol may decrease the anticoagulant activities of Abciximab.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Ethinyl Estradiol.
AcenocoumarolEthinyl Estradiol may decrease the anticoagulant activities of Acenocoumarol.
AcetaminophenThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Acetaminophen.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Ethinyl Estradiol.
AfatinibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Afatinib.
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Ethinyl Estradiol.
AlbendazoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Albendazole.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Ethinyl Estradiol.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Ethinyl Estradiol.
AldosteroneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Aldosterone.
AlectinibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Alfentanil.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Ethinyl Estradiol.
AmantadineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Amantadine.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Ethinyl Estradiol.
Aminohippuric acidThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Aminohippuric acid.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Ethinyl Estradiol.
AmiodaroneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Amitriptyline.
AmlodipineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Amlodipine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Ethinyl Estradiol.
AmprenavirThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Amsacrine.
AnastrozoleThe therapeutic efficacy of Anastrozole can be decreased when used in combination with Ethinyl Estradiol.
AncrodEthinyl Estradiol may decrease the anticoagulant activities of Ancrod.
Anthrax immune globulin humanEthinyl Estradiol may increase the thrombogenic activities of Anthrax immune globulin human.
Antithrombin III humanEthinyl Estradiol may decrease the anticoagulant activities of Antithrombin III human.
ApixabanEthinyl Estradiol may decrease the anticoagulant activities of Apixaban.
AprepitantThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Aprepitant.
ArdeparinEthinyl Estradiol may decrease the anticoagulant activities of Ardeparin.
ArgatrobanEthinyl Estradiol may decrease the anticoagulant activities of Argatroban.
AstemizoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Ethinyl Estradiol can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Atorvastatin.
AzelastineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Azithromycin.
BecaplerminEthinyl Estradiol may decrease the anticoagulant activities of Becaplermin.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Ethinyl Estradiol.
BenzocaineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Benzocaine.
BepridilThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Ethinyl Estradiol.
BexaroteneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Bexarotene.
BiperidenThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Biperiden.
BivalirudinEthinyl Estradiol may decrease the anticoagulant activities of Bivalirudin.
BoceprevirThe metabolism of Ethinyl Estradiol can be decreased when combined with Boceprevir.
BortezomibThe metabolism of Ethinyl Estradiol can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Bosutinib.
BromocriptineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Bromocriptine.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Ethinyl Estradiol.
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Ethinyl Estradiol.
BuprenorphineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Buprenorphine.
BuspironeThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Buspirone.
C1 Esterase Inhibitor (Human)Ethinyl Estradiol may increase the thrombogenic activities of C1 Esterase Inhibitor (Human).
C1 Esterase Inhibitor (Recombinant)Ethinyl Estradiol may increase the thrombogenic activities of C1 Esterase Inhibitor (Recombinant).
CabazitaxelThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Cabazitaxel.
CaffeineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Caffeine.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Ethinyl Estradiol.
CanagliflozinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Carbamazepine.
CarvedilolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Caspofungin.
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Ethinyl Estradiol.
CeritinibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ceritinib.
CertoparinEthinyl Estradiol may decrease the anticoagulant activities of Certoparin.
Chenodeoxycholic acidThe therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Ethinyl Estradiol.
ChloroquineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Chloroquine.
ChlorpromazineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Ethinyl Estradiol.
ChlorpropamideThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Chlorprothixene.
CholesterolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Cholic Acid.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Ethinyl Estradiol.
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Ethinyl Estradiol.
CilazaprilThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Cimetidine.
CiprofloxacinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ciprofloxacin.
CitalopramThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Citalopram.
Citric AcidEthinyl Estradiol may decrease the anticoagulant activities of Citric Acid.
ClarithromycinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Ethinyl Estradiol can be decreased when combined with Clemastine.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Ethinyl Estradiol.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Ethinyl Estradiol.
ClofazimineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Clofazimine.
ClomipramineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Clomipramine.
ClotrimazoleThe metabolism of Ethinyl Estradiol can be decreased when combined with Clotrimazole.
CobicistatThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Cobicistat.
ColchicineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Colchicine.
ColesevelamThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Colesevelam.
ColforsinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Conivaptan.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Ethinyl Estradiol.
CrizotinibThe metabolism of Ethinyl Estradiol can be decreased when combined with Crizotinib.
CyclophosphamideThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Cyclophosphamide.
CyclosporineThe metabolism of Ethinyl Estradiol can be decreased when combined with Cyclosporine.
Dabigatran etexilateEthinyl Estradiol may decrease the anticoagulant activities of Dabigatran etexilate.
DabrafenibThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Dabrafenib.
DaclatasvirThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Dactinomycin.
DalteparinEthinyl Estradiol may decrease the anticoagulant activities of Dalteparin.
DanaparoidEthinyl Estradiol may decrease the anticoagulant activities of Danaparoid.
DarunavirThe metabolism of Ethinyl Estradiol can be decreased when combined with Darunavir.
DasatinibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Daunorubicin.
DeferasiroxThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with Ethinyl Estradiol.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Ethinyl Estradiol.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Ethinyl Estradiol.
DelavirdineThe metabolism of Ethinyl Estradiol can be decreased when combined with Delavirdine.
DesipramineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Desipramine.
DesirudinEthinyl Estradiol may decrease the anticoagulant activities of Desirudin.
DesloratadineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Desloratadine.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Ethinyl Estradiol.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Ethinyl Estradiol.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Ethinyl Estradiol.
DexamethasoneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Dexamethasone.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Ethinyl Estradiol.
DextranEthinyl Estradiol may decrease the anticoagulant activities of Dextran.
Dextran 40Ethinyl Estradiol may decrease the anticoagulant activities of Dextran 40.
Dextran 70Ethinyl Estradiol may decrease the anticoagulant activities of Dextran 70.
Dextran 75Ethinyl Estradiol may decrease the anticoagulant activities of Dextran 75.
DextromethorphanThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Dextromethorphan.
DiclofenacThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Diclofenac.
DicoumarolEthinyl Estradiol may decrease the anticoagulant activities of Dicoumarol.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Ethinyl Estradiol.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Ethinyl Estradiol.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Ethinyl Estradiol.
DigoxinThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Digoxin.
DihydroergotamineThe metabolism of Ethinyl Estradiol can be decreased when combined with Dihydroergotamine.
DiltiazemThe metabolism of Ethinyl Estradiol can be decreased when combined with Diltiazem.
DipyridamoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Dipyridamole.
DoxazosinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Doxepin.
DoxorubicinThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Doxorubicin.
DoxycyclineThe metabolism of Ethinyl Estradiol can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Dronabinol.
DronedaroneThe metabolism of Ethinyl Estradiol can be decreased when combined with Dronedarone.
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Ethinyl Estradiol.
DyphyllineThe serum concentration of Dyphylline can be increased when it is combined with Ethinyl Estradiol.
Edetic AcidEthinyl Estradiol may decrease the anticoagulant activities of Edetic Acid.
EdoxabanEthinyl Estradiol may decrease the anticoagulant activities of Edoxaban.
EfavirenzThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Efavirenz.
ElbasvirThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Elbasvir.
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Ethinyl Estradiol.
EnalaprilThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Enalapril.
EnoxaparinEthinyl Estradiol may decrease the anticoagulant activities of Enoxaparin.
EnzalutamideThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Enzalutamide.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Ethinyl Estradiol.
EquilinThe serum concentration of Equilin can be increased when it is combined with Ethinyl Estradiol.
ErgonovineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ergotamine.
ErythromycinThe metabolism of Ethinyl Estradiol can be decreased when combined with Erythromycin.
Eslicarbazepine acetateThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Eslicarbazepine acetate.
EstramustineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Estriol.
EstroneThe serum concentration of Estrone can be increased when it is combined with Ethinyl Estradiol.
EstroneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Estrone.
Ethyl biscoumacetateEthinyl Estradiol may decrease the anticoagulant activities of Ethyl biscoumacetate.
EtoposideThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Etoposide.
EtravirineThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Etravirine.
ExemestaneThe therapeutic efficacy of Exemestane can be decreased when used in combination with Ethinyl Estradiol.
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Ethinyl Estradiol.
FelodipineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Felodipine.
FentanylThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fentanyl.
FexofenadineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fidaxomicin.
FluconazoleThe metabolism of Ethinyl Estradiol can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Ethinyl Estradiol.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Ethinyl Estradiol.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Ethinyl Estradiol.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Ethinyl Estradiol.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Ethinyl Estradiol.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Ethinyl Estradiol.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Ethinyl Estradiol.
FluoxetineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fluphenazine.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Ethinyl Estradiol.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Ethinyl Estradiol.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Ethinyl Estradiol.
FlurazepamThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Flurazepam.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Ethinyl Estradiol.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Ethinyl Estradiol.
FluvoxamineThe metabolism of Ethinyl Estradiol can be decreased when combined with Fluvoxamine.
Fondaparinux sodiumEthinyl Estradiol may decrease the anticoagulant activities of Fondaparinux sodium.
FosamprenavirThe metabolism of Ethinyl Estradiol can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Ethinyl Estradiol can be increased when combined with Fosphenytoin.
Fusidic AcidThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fusidic Acid.
GefitinibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Gefitinib.
GenisteinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Genistein.
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Ethinyl Estradiol.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Ethinyl Estradiol.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Ethinyl Estradiol.
GlipizideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Ethinyl Estradiol.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Ethinyl Estradiol.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Ethinyl Estradiol.
GlyburideThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Gramicidin D.
GrepafloxacinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Grepafloxacin.
HaloperidolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Haloperidol.
HeparinEthinyl Estradiol may decrease the anticoagulant activities of Heparin.
HirulogEthinyl Estradiol may decrease the anticoagulant activities of Hirulog.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Ethinyl Estradiol.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Ethinyl Estradiol.
IdelalisibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Idelalisib.
ImatinibThe metabolism of Ethinyl Estradiol can be decreased when combined with Imatinib.
ImipramineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Imipramine.
IndinavirThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Indomethacin.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Ethinyl Estradiol.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Ethinyl Estradiol.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Ethinyl Estradiol.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Ethinyl Estradiol.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Ethinyl Estradiol.
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Ethinyl Estradiol.
IsavuconazoniumThe metabolism of Ethinyl Estradiol can be decreased when combined with Isavuconazonium.
IsradipineThe metabolism of Ethinyl Estradiol can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ivermectin.
KetamineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ketamine.
KetoconazoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ketoconazole.
LansoprazoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lapatinib.
LenalidomideEthinyl Estradiol may increase the thrombogenic activities of Lenalidomide.
LepirudinEthinyl Estradiol may decrease the anticoagulant activities of Lepirudin.
LevofloxacinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Levofloxacin.
LevothyroxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Ethinyl Estradiol.
LevothyroxineThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lidocaine.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Ethinyl Estradiol.
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Ethinyl Estradiol.
LiothyronineThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Liothyronine.
LiotrixThe therapeutic efficacy of Liotrix can be decreased when used in combination with Ethinyl Estradiol.
LiotrixThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Liotrix.
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Ethinyl Estradiol.
LisinoprilThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lisinopril.
LomitapideThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Loratadine.
LosartanThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Losartan.
LovastatinThe metabolism of Ethinyl Estradiol can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Lumacaftor.
MaprotilineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Maprotiline.
MebendazoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Mebendazole.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Ethinyl Estradiol.
MefloquineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Megestrol acetate.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Ethinyl Estradiol.
MeprobamateThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Meprobamate.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Ethinyl Estradiol.
MethadoneThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Methadone.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Ethinyl Estradiol.
MetoprololThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Metoprolol.
MibefradilThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Midazolam.
MifepristoneThe metabolism of Ethinyl Estradiol can be decreased when combined with Mifepristone.
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Ethinyl Estradiol.
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Ethinyl Estradiol.
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Ethinyl Estradiol.
MitomycinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Mitoxantrone.
ModafinilThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Modafinil.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Ethinyl Estradiol.
MorphineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Morphine.
NadroparinEthinyl Estradiol may decrease the anticoagulant activities of Nadroparin.
NafcillinThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Nafcillin.
NaltrexoneThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Naringenin.
NateglinideThe therapeutic efficacy of Nateglinide can be decreased when used in combination with Ethinyl Estradiol.
NefazodoneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Ethinyl Estradiol can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Nicardipine.
NifedipineThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Nifedipine.
NilotinibThe metabolism of Ethinyl Estradiol can be decreased when combined with Nilotinib.
NisoldipineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Nitrendipine.
NorethisteroneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Norethisterone.
OlaparibThe metabolism of Ethinyl Estradiol can be decreased when combined with Olaparib.
OmeprazoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Omeprazole.
OsimertinibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Osimertinib.
OspemifeneThe risk or severity of adverse effects can be increased when Ethinyl Estradiol is combined with Ospemifene.
OtamixabanEthinyl Estradiol may decrease the anticoagulant activities of Otamixaban.
P-NitrophenolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Palbociclib.
Palmitic AcidThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Palmitic Acid.
PantoprazoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Pantoprazole.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Ethinyl Estradiol.
ParoxetineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Paroxetine.
PentobarbitalThe metabolism of Ethinyl Estradiol can be increased when combined with Pentobarbital.
Pentosan PolysulfateEthinyl Estradiol may decrease the anticoagulant activities of Pentosan Polysulfate.
PerindoprilThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Perindopril.
PhenforminThe therapeutic efficacy of Phenformin can be decreased when used in combination with Ethinyl Estradiol.
PhenindioneEthinyl Estradiol may decrease the anticoagulant activities of Phenindione.
PhenobarbitalThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Phenobarbital.
PhenprocoumonEthinyl Estradiol may decrease the anticoagulant activities of Phenprocoumon.
PhenytoinThe metabolism of Ethinyl Estradiol can be increased when combined with Phenytoin.
PimozideThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Pimozide.
PioglitazoneThe therapeutic efficacy of Pioglitazone can be decreased when used in combination with Ethinyl Estradiol.
Platelet Activating FactorThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Platelet Activating Factor.
PonatinibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ponatinib.
PosaconazoleThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Posaconazole.
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Ethinyl Estradiol.
PravastatinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Pravastatin.
PrazosinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Prazosin.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Ethinyl Estradiol.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Ethinyl Estradiol.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Ethinyl Estradiol.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Ethinyl Estradiol.
PrimidoneThe metabolism of Ethinyl Estradiol can be increased when combined with Primidone.
ProbenecidThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Probenecid.
ProgesteroneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Progesterone.
PromethazineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Propafenone.
PropranololThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Propranolol.
Protein CEthinyl Estradiol may decrease the anticoagulant activities of Protein C.
ProtocatechualdehydeEthinyl Estradiol may decrease the anticoagulant activities of Protocatechualdehyde.
ProtriptylineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Protriptyline.
QuercetinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Quercetin.
QuinacrineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Quinine.
RanitidineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ranolazine.
ReboxetineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Regorafenib.
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Ethinyl Estradiol.
ReserpineThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Reserpine.
ReviparinEthinyl Estradiol may decrease the anticoagulant activities of Reviparin.
RifabutinThe metabolism of Ethinyl Estradiol can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Rifampicin.
RifapentineThe metabolism of Ethinyl Estradiol can be increased when combined with Rifapentine.
RilpivirineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Rilpivirine.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Ethinyl Estradiol.
RitonavirThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Ritonavir.
RivaroxabanEthinyl Estradiol may decrease the anticoagulant activities of Rivaroxaban.
RolapitantThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Rolapitant.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Ethinyl Estradiol.
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Ethinyl Estradiol.
RufinamideThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Rufinamide.
SaquinavirThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Saquinavir.
SaxagliptinThe therapeutic efficacy of Saxagliptin can be decreased when used in combination with Ethinyl Estradiol.
ScopolamineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Selegiline.
SertralineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Sertraline.
SildenafilThe metabolism of Ethinyl Estradiol can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Simvastatin.
SirolimusThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Sirolimus.
SitagliptinThe therapeutic efficacy of Sitagliptin can be decreased when used in combination with Ethinyl Estradiol.
Somatropin recombinantThe therapeutic efficacy of Somatropin recombinant can be decreased when used in combination with Ethinyl Estradiol.
SorafenibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Sorafenib.
SpironolactoneThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Streptozocin.
SulfinpyrazoneThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleThe metabolism of Ethinyl Estradiol can be decreased when combined with Sulfisoxazole.
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Ethinyl Estradiol.
SumatriptanThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Sunitinib.
TacrineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Tacrolimus.
TamoxifenThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Tamoxifen.
Taurocholic AcidThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Taurocholic Acid.
TelaprevirThe metabolism of Ethinyl Estradiol can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Ethinyl Estradiol can be decreased when combined with Telithromycin.
TelmisartanThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Telmisartan.
TemsirolimusThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Temsirolimus.
TerazosinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Terfenadine.
TesmilifeneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Testosterone.
ThalidomideEthinyl Estradiol may increase the thrombogenic activities of Thalidomide.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Ethinyl Estradiol.
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Ethinyl Estradiol.
TicagrelorThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Ethinyl Estradiol can be decreased when combined with Ticlopidine.
TipranavirEthinyl Estradiol may increase the dermatologic adverse activities of Tipranavir.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Ethinyl Estradiol.
TocilizumabThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Tocilizumab.
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Ethinyl Estradiol.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Ethinyl Estradiol.
TolvaptanThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Tolvaptan.
TrazodoneThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Trazodone.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Ethinyl Estradiol.
TrifluoperazineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Triflupromazine.
TrimethoprimThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Trimipramine.
TroglitazoneThe therapeutic efficacy of Troglitazone can be decreased when used in combination with Ethinyl Estradiol.
TroleandomycinThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Troleandomycin.
Ursodeoxycholic acidThe therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Ethinyl Estradiol.
VenlafaxineThe metabolism of Ethinyl Estradiol can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Ethinyl Estradiol can be decreased when combined with Verapamil.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Ethinyl Estradiol.
VinblastineThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Vinorelbine.
Vitamin CThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Vitamin C.
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Ethinyl Estradiol.
VoriconazoleThe metabolism of Ethinyl Estradiol can be decreased when combined with Voriconazole.
WarfarinEthinyl Estradiol may decrease the anticoagulant activities of Warfarin.
XimelagatranEthinyl Estradiol may decrease the anticoagulant activities of Ximelagatran.
ZimelidineThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Ethinyl Estradiol can be decreased when combined with Ziprasidone.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription fact...
Gene Name:
ESR1
Uniprot ID:
P03372
Molecular Weight:
66215.45 Da
References
  1. Micevych PE, Chaban V, Ogi J, Dewing P, Lu JK, Sinchak K: Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures. Endocrinology. 2007 Feb;148(2):782-9. Epub 2006 Nov 9. [PubMed:17095591 ]
  2. Garcia-Segura LM, Sanz A, Mendez P: Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection. Neuroendocrinology. 2006;84(4):275-9. Epub 2006 Nov 23. [PubMed:17124377 ]
  3. Brama M, Gnessi L, Basciani S, Cerulli N, Politi L, Spera G, Mariani S, Cherubini S, Scotto d'Abusco A, Scandurra R, Migliaccio S: Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):102-8. Epub 2006 Nov 27. [PubMed:17125913 ]
  4. Lehnes K, Winder AD, Alfonso C, Kasid N, Simoneaux M, Summe H, Morgan E, Iann MC, Duncan J, Eagan M, Tavaluc R, Evans CH Jr, Russell R, Wang A, Hu F, Stoica A: The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway. Endocrinology. 2007 Mar;148(3):1171-80. Epub 2006 Nov 30. [PubMed:17138652 ]
  5. Mukai H, Tsurugizawa T, Ogiue-Ikeda M, Murakami G, Hojo Y, Ishii H, Kimoto T, Kawato S: Local neurosteroid production in the hippocampus: influence on synaptic plasticity of memory. Neuroendocrinology. 2006;84(4):255-63. Epub 2006 Dec 1. [PubMed:17142999 ]
  6. Notch EG, Mayer GD: 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8. doi: 10.1016/j.aquatox.2009.01.001. Epub 2009 Jan 23. [PubMed:19237207 ]
  7. Bennink HJ: Reprint of Are all estrogens the same? Maturitas. 2008 Sep-Oct;61(1-2):195-201. [PubMed:19434891 ]
  8. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and is...
Gene Name:
NR1I2
Uniprot ID:
O75469
Molecular Weight:
49761.245 Da
References
  1. Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR: Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. Mol Endocrinol. 2007 May;21(5):1028-38. Epub 2007 Feb 27. [PubMed:17327420 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Wang B, Sanchez RI, Franklin RB, Evans DC, Huskey SE: The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol. Drug Metab Dispos. 2004 Nov;32(11):1209-12. Epub 2004 Aug 10. [PubMed:15304426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL: Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology. 2000 Jan;118(1):163-72. [PubMed:10611165 ]
  2. Huang L, Smit JW, Meijer DK, Vore M: Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats. Hepatology. 2000 Jul;32(1):66-72. [PubMed:10869290 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Virus receptor activity
Specific Function:
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.(Microbial infection) Acts as a receptor for hepatitis B virus.
Gene Name:
SLC10A1
Uniprot ID:
Q14973
Molecular Weight:
38118.64 Da
References
  1. Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL: Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology. 2000 Jan;118(1):163-72. [PubMed:10611165 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Kauffmann HM, Schrenk D: Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochem Biophys Res Commun. 1998 Apr 17;245(2):325-31. [PubMed:9571149 ]
  2. Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, Suchy FJ, Keppler D, Boyer JL: The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology. 1997 Jul;113(1):255-64. [PubMed:9207286 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Kim WY, Benet LZ: P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. [PubMed:15290871 ]
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Drug created on June 13, 2005 07:24 / Updated on September 29, 2016 03:39