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Identification
NameFusidic Acid
Accession NumberDB02703  (EXPT01507)
TypeSmall Molecule
GroupsApproved
Description

An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.

Structure
Thumb
Synonyms
Fucidate
Fucidin acid
Fusidate
Fusidic acid
Fusidine
Ramycin
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Fucidin Cream 2%cream2 %topicalLeo Pharma Inc1984-12-31Not applicableCanada
Fucidin Film Coated Tab 250mgtablet250 mgoralLeo Pharma Inc1991-12-312009-06-05Canada
Fucidin Intertulle 2%dressing2 %topicalLeo Pharma Inc1984-12-312004-07-23Canada
Fucidin Leo Sus 246mg/5mlsuspension246 mgoralLeo Pharma Inc1980-12-312004-07-23Canada
Fucidin Ointment 2%ointment2 %topicalLeo Pharma Inc1984-12-31Not applicableCanada
Fucithalmicdrops1 %ophthalmicAmdipharm Limited2001-08-07Not applicableCanada
Fucithalmicdrops1 %ophthalmicAmdipharm Limited2001-08-29Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
FucidinNot Available
FucidineNot Available
FudicNot Available
TakstaNot Available
Brand mixtures
NameLabellerIngredients
Fucidin HLeo Pharma Inc
Fucidin Leo Injection KitLeo Pharma Inc
Salts
Name/CASStructureProperties
Fucidate Sodium
Thumb
  • InChI Key: IECPWNUMDGFDKC-MZJAQBGESA-N
  • Monoisotopic Mass: 516.345089268
  • Average Mass: 516.7092
DBSALT000340
Categories
UNII59XE10C19C
CAS number6990-06-3
WeightAverage: 516.7092
Monoisotopic: 516.345089268
Chemical FormulaC31H48O6
InChI KeyInChIKey=IECPWNUMDGFDKC-MZJAQBGESA-N
InChI
InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1
IUPAC Name
2-[(1S,2S,5R,6S,7S,10S,11S,13S,14Z,15R,17R)-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-ylidene]-6-methylhept-5-enoic acid
SMILES
O[C@@H]1CC[C@@]2(C)[C@@]([H])(CC[C@@]3(C)[C@@]2([H])[[email protected]](O)C[C@@]2([H])\C([C@@H](OC(=O)C)C[C@]32C)=C(/CCC=C(C)C)C(O)=O)[C@@H]1C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as steroid esters. These are compounds containing a steroid moiety which bears a carboxylic acid ester group.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassSteroid esters
Direct ParentSteroid esters
Alternative Parents
Substituents
  • Steroid ester
  • 3-alpha-hydroxysteroid
  • 11-hydroxysteroid
  • 11-alpha-hydroxysteroid
  • Hydroxysteroid
  • 3-hydroxysteroid
  • Carbocyclic fatty acid
  • Medium-chain fatty acid
  • Methyl-branched fatty acid
  • Branched fatty acid
  • Fatty acyl
  • Fatty acid
  • Unsaturated fatty acid
  • Acetate salt
  • Cyclic alcohol
  • Secondary alcohol
  • Carboxylic acid ester
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of bacterial infections.
PharmacodynamicsFusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections.
Mechanism of actionFusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.
Related Articles
AbsorptionSodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.
Volume of distributionNot Available
Protein binding97 to 99%
Metabolism

Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.

SubstrateEnzymesProduct
Fusidic Acid
Not Available
Dicarboxylic acidDetails
Fusidic Acid
Not Available
3-keto fusidic acidDetails
Fusidic Acid
Not Available
dicarboxylic esterDetails
Fusidic Acid
Not Available
Glucuronide fusidic acidDetails
Fusidic Acid
Not Available
Hydroxy fusidic acidDetails
Route of eliminationNot Available
Half lifeApproximately 5 to 6 hours in adults.
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9691
Blood Brain Barrier+0.7909
Caco-2 permeable-0.6089
P-glycoprotein substrateSubstrate0.8165
P-glycoprotein inhibitor INon-inhibitor0.6004
P-glycoprotein inhibitor IIInhibitor0.7848
Renal organic cation transporterNon-inhibitor0.8424
CYP450 2C9 substrateNon-substrate0.8218
CYP450 2D6 substrateNon-substrate0.9349
CYP450 3A4 substrateSubstrate0.798
CYP450 1A2 substrateNon-inhibitor0.9337
CYP450 2C9 inhibitorNon-inhibitor0.8834
CYP450 2D6 inhibitorNon-inhibitor0.9544
CYP450 2C19 inhibitorNon-inhibitor0.9347
CYP450 3A4 inhibitorNon-inhibitor0.76
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.819
Ames testNon AMES toxic0.8305
CarcinogenicityNon-carcinogens0.9508
BiodegradationNot ready biodegradable0.9753
Rat acute toxicity3.5929 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9403
hERG inhibition (predictor II)Non-inhibitor0.7564
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Creamtopical2 %
Tabletoral250 mg
Creamtopical
Dressingtopical2 %
Kitintravenous
Suspensionoral246 mg
Ointmenttopical2 %
Dropsophthalmic1 %
Prices
Unit descriptionCostUnit
Fucidin 2 % Cream0.66USD g
Fucidin 2 % Ointment0.66USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point192.5 °CPhysProp
pKa5.35MERCK INDEX (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.00521 mg/mLALOGPS
logP4.97ALOGPS
logP4.42ChemAxon
logS-5ALOGPS
pKa (Strongest Acidic)4.66ChemAxon
pKa (Strongest Basic)-0.2ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area104.06 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity144.12 m3·mol-1ChemAxon
Polarizability59.77 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Vanangamudi Subramaniam Sulur, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Haridas Sankar, Selvaraj Balkrishnan, " PROCESS TO MAKE FUSIDIC ACID CREAM." U.S. Patent US20110301138, issued December 08, 2011.

US20110301138
General ReferencesNot Available
External Links
ATC CodesD06AX01D09AA02J01XC01S01AA13
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Fusidic Acid.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Fusidic Acid.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Fusidic Acid.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Fusidic Acid.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Fusidic Acid.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Fusidic Acid.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Fusidic Acid.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Fusidic Acid.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fusidic Acid.
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Fusidic Acid.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fusidic Acid.
ArmodafinilThe serum concentration of Armodafinil can be increased when it is combined with Fusidic Acid.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Fusidic Acid.
AtorvastatinThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Atorvastatin.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Fusidic Acid.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Fusidic Acid.
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Fusidic Acid.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Fusidic Acid.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fusidic Acid.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Fusidic Acid.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Fusidic Acid.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Fusidic Acid.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Fusidic Acid.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Fusidic Acid.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Fusidic Acid.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Fusidic Acid.
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Fusidic Acid.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Fusidic Acid.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Fusidic Acid.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Fusidic Acid.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Fusidic Acid.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Fusidic Acid.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Fusidic Acid.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Fusidic Acid.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Fusidic Acid.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Fusidic Acid.
ClidiniumThe serum concentration of Clidinium can be increased when it is combined with Fusidic Acid.
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Fusidic Acid.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Fusidic Acid.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Fusidic Acid.
CocaineThe serum concentration of Cocaine can be increased when it is combined with Fusidic Acid.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Fusidic Acid.
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Fusidic Acid.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Fusidic Acid.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Fusidic Acid.
Cyproterone acetateThe serum concentration of Cyproterone acetate can be increased when it is combined with Fusidic Acid.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Fusidic Acid.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Fusidic Acid.
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Fusidic Acid.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Fusidic Acid.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Fusidic Acid.
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Fusidic Acid.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Fusidic Acid.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Fusidic Acid.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Fusidic Acid.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Fusidic Acid.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Fusidic Acid.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Fusidic Acid.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Fusidic Acid.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fusidic Acid.
DoxazosinThe serum concentration of Doxazosin can be increased when it is combined with Fusidic Acid.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Fusidic Acid.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Fusidic Acid.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Fusidic Acid.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Fusidic Acid.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Fusidic Acid.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Fusidic Acid.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Fusidic Acid.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Fusidic Acid.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Fusidic Acid.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Fusidic Acid.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Fusidic Acid.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Fusidic Acid.
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Fusidic Acid.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Fusidic Acid.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Fusidic Acid.
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Fusidic Acid.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Fusidic Acid.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Fusidic Acid.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Fusidic Acid.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Fusidic Acid.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Fusidic Acid.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Fusidic Acid.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Fusidic Acid.
FluvastatinThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Fluvastatin.
FosaprepitantThe serum concentration of Fosaprepitant can be increased when it is combined with Fusidic Acid.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Fusidic Acid.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Fusidic Acid.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Fusidic Acid.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Fusidic Acid.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Fusidic Acid.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Fusidic Acid.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Fusidic Acid.
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Fusidic Acid.
IsosorbideThe serum concentration of Isosorbide can be increased when it is combined with Fusidic Acid.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Fusidic Acid.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Fusidic Acid.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Fusidic Acid.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Fusidic Acid.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Fusidic Acid.
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Fusidic Acid.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Fusidic Acid.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Fusidic Acid.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Fusidic Acid.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Fusidic Acid.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Fusidic Acid.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Fusidic Acid.
LopinavirThe serum concentration of Fusidic Acid can be increased when it is combined with Lopinavir.
LovastatinThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Lovastatin.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Fusidic Acid.
MacitentanThe serum concentration of MACITENTAN can be increased when it is combined with Fusidic Acid.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Fusidic Acid.
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Fusidic Acid.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Fusidic Acid.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Fusidic Acid.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Fusidic Acid.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Fusidic Acid.
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Fusidic Acid.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fusidic Acid.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Fusidic Acid.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Fusidic Acid.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Fusidic Acid.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Fusidic Acid.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Fusidic Acid.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Fusidic Acid.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Fusidic Acid.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Fusidic Acid.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Fusidic Acid.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Fusidic Acid.
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Fusidic Acid.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Fusidic Acid.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Fusidic Acid.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Fusidic Acid.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Fusidic Acid.
PitavastatinThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Pitavastatin.
PravastatinThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Pravastatin.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Fusidic Acid.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Fusidic Acid.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Fusidic Acid.
QuinineThe serum concentration of Quinine can be increased when it is combined with Fusidic Acid.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Fusidic Acid.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Fusidic Acid.
RitonavirThe serum concentration of Fusidic Acid can be increased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Fusidic Acid.
RosuvastatinThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Rosuvastatin.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Fusidic Acid.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Fusidic Acid.
SaquinavirThe serum concentration of Fusidic Acid can be increased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Fusidic Acid.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Fusidic Acid.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Fusidic Acid.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Fusidic Acid.
SimvastatinThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Simvastatin.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Fusidic Acid.
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Fusidic Acid.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Fusidic Acid.
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Fusidic Acid.
StiripentolThe serum concentration of Stiripentol can be increased when it is combined with Fusidic Acid.
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Fusidic Acid.
SulfisoxazoleThe serum concentration of Sulfisoxazole can be increased when it is combined with Fusidic Acid.
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Fusidic Acid.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Fusidic Acid.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Fusidic Acid.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Fusidic Acid.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Fusidic Acid.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Fusidic Acid.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Fusidic Acid.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Fusidic Acid.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Fusidic Acid.
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Fusidic Acid.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Fusidic Acid.
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Fusidic Acid.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Fusidic Acid.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Fusidic Acid.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Fusidic Acid.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Fusidic Acid.
Trastuzumab emtansineThe serum concentration of ado-trastuzumab emtansine can be increased when it is combined with Fusidic Acid.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Fusidic Acid.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Fusidic Acid.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Fusidic Acid.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Fusidic Acid.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Fusidic Acid.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Fusidic Acid.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Fusidic Acid.
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Fusidic Acid.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Fusidic Acid.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Fusidic Acid.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Fusidic Acid.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Fusidic Acid.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Fusidic Acid.
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Fusidic Acid.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Fusidic Acid.
Food Interactions
  • Take with food to reduce irritation.

Targets

Kind
Protein
Organism
Thermus thermophilus
Pharmacological action
yes
Actions
inhibitor
General Function:
Translation elongation factor activity
Specific Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA an...
Gene Name:
fusA
Uniprot ID:
P13551
Molecular Weight:
76878.69 Da
References
  1. Lannergard J, Norstrom T, Hughes D: Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 2009 May;53(5):2059-65. doi: 10.1128/AAC.00871-08. Epub 2009 Mar 16. [PubMed:19289529 ]
  2. Chen Y, Koripella RK, Sanyal S, Selmer M: Staphylococcus aureus elongation factor G--structure and analysis of a target for fusidic acid. FEBS J. 2010 Sep;277(18):3789-803. doi: 10.1111/j.1742-4658.2010.07780.x. Epub 2010 Aug 13. [PubMed:20718859 ]
  3. Gao YG, Selmer M, Dunham CM, Weixlbaumer A, Kelley AC, Ramakrishnan V: The structure of the ribosome with elongation factor G trapped in the posttranslocational state. Science. 2009 Oct 30;326(5953):694-9. doi: 10.1126/science.1179709. [PubMed:19833919 ]
Kind
Protein
Organism
Salmonella typhi
Pharmacological action
unknown
Actions
inhibitor
General Function:
Chloramphenicol o-acetyltransferase activity
Specific Function:
This enzyme is an effector of chloramphenicol resistance in bacteria.
Gene Name:
cat
Uniprot ID:
P62580
Molecular Weight:
25663.08 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Murray IA, Cann PA, Day PJ, Derrick JP, Sutcliffe MJ, Shaw WV, Leslie AG: Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site. J Mol Biol. 1995 Dec 15;254(5):993-1005. [PubMed:7500366 ]
  4. Bennett AD, Shaw WV: Resistance to fusidic acid in Escherichia coli mediated by the type I variant of chloramphenicol acetyltransferase. A plasmid-encoded mechanism involving antibiotic binding. Biochem J. 1983 Oct 1;215(1):29-38. [PubMed:6354181 ]
  5. Day PJ, Murray IA, Shaw WV: Properties of hybrid active sites in oligomeric proteins: kinetic and ligand binding studies with chloramphenicol acetyltransferase trimers. Biochemistry. 1995 May 16;34(19):6416-22. [PubMed:7756272 ]
Kind
Protein
Organism
Escherichia coli
Pharmacological action
unknown
Actions
inhibitor
General Function:
Chloramphenicol o-acetyltransferase activity
Specific Function:
This enzyme is an effector of chloramphenicol resistance in bacteria.
Gene Name:
cat3
Uniprot ID:
P00484
Molecular Weight:
24993.32 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Murray IA, Cann PA, Day PJ, Derrick JP, Sutcliffe MJ, Shaw WV, Leslie AG: Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site. J Mol Biol. 1995 Dec 15;254(5):993-1005. [PubMed:7500366 ]
  4. Bennett AD, Shaw WV: Resistance to fusidic acid in Escherichia coli mediated by the type I variant of chloramphenicol acetyltransferase. A plasmid-encoded mechanism involving antibiotic binding. Biochem J. 1983 Oct 1;215(1):29-38. [PubMed:6354181 ]
  5. Day PJ, Murray IA, Shaw WV: Properties of hybrid active sites in oligomeric proteins: kinetic and ligand binding studies with chloramphenicol acetyltransferase trimers. Biochemistry. 1995 May 16;34(19):6416-22. [PubMed:7756272 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Bode KA, Donner MG, Leier I, Keppler D: Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8. [PubMed:12106615 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Bode KA, Donner MG, Leier I, Keppler D: Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8. [PubMed:12106615 ]
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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:18