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Identification
NameFusidic Acid
Accession NumberDB02703  (EXPT01507)
TypeSmall Molecule
GroupsApproved
DescriptionAn antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.
Structure
Thumb
Synonyms
Fucidate
Fucidin acid
Fusidate
Fusidic acid
Fusidine
Ramycin
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Fucidin Cream 2%cream2 %topicalLeo Pharma Inc1984-12-31Not applicableCanada
Fucidin Film Coated Tab 250mgtablet250 mgoralLeo Pharma Inc1991-12-312009-06-05Canada
Fucidin Intertulle 2%dressing2 %topicalLeo Pharma Inc1984-12-312004-07-23Canada
Fucidin Leo Sus 246mg/5mlsuspension246 mgoralLeo Pharma Inc1980-12-312004-07-23Canada
Fucidin Ointment 2%ointment2 %topicalLeo Pharma Inc1984-12-31Not applicableCanada
Fucithalmicdrops1 %ophthalmicAmdipharm Limited2001-08-07Not applicableCanada
Fucithalmicdrops1 %ophthalmicAmdipharm Limited2001-08-29Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
FucidinNot Available
FucidineNot Available
FudicNot Available
TakstaNot Available
Brand mixtures
NameLabellerIngredients
Fucidin HLeo Pharma Inc
Fucidin Leo Injection KitLeo Pharma Inc
Salts
Name/CASStructureProperties
Fucidate Sodium
Thumb
  • InChI Key: IECPWNUMDGFDKC-MZJAQBGESA-N
  • Monoisotopic Mass: 516.345089268
  • Average Mass: 516.7092
DBSALT000340
Categories
UNII59XE10C19C
CAS number6990-06-3
WeightAverage: 516.7092
Monoisotopic: 516.345089268
Chemical FormulaC31H48O6
InChI KeyInChIKey=IECPWNUMDGFDKC-MZJAQBGESA-N
InChI
InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1
IUPAC Name
2-[(1S,2S,5R,6S,7S,10S,11S,13S,14Z,15R,17R)-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-ylidene]-6-methylhept-5-enoic acid
SMILES
O[C@@H]1CC[C@@]2(C)[C@@]([H])(CC[C@@]3(C)[C@@]2([H])[[email protected]](O)C[C@@]2([H])\C([C@@H](OC(=O)C)C[C@]32C)=C(/CCC=C(C)C)C(O)=O)[C@@H]1C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as steroid esters. These are compounds containing a steroid moiety which bears a carboxylic acid ester group.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassSteroid esters
Direct ParentSteroid esters
Alternative Parents
Substituents
  • Steroid ester
  • 3-alpha-hydroxysteroid
  • 11-hydroxysteroid
  • 11-alpha-hydroxysteroid
  • Hydroxysteroid
  • 3-hydroxysteroid
  • Carbocyclic fatty acid
  • Medium-chain fatty acid
  • Methyl-branched fatty acid
  • Branched fatty acid
  • Fatty acyl
  • Fatty acid
  • Unsaturated fatty acid
  • Acetate salt
  • Cyclic alcohol
  • Secondary alcohol
  • Carboxylic acid ester
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of bacterial infections.
PharmacodynamicsFusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections.
Mechanism of actionFusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.
Related Articles
AbsorptionSodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.
Volume of distributionNot Available
Protein binding97 to 99%
Metabolism

Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.

SubstrateEnzymesProduct
Fusidic Acid
Not Available
Dicarboxylic acidDetails
Fusidic Acid
Not Available
3-keto fusidic acidDetails
Fusidic Acid
Not Available
dicarboxylic esterDetails
Fusidic Acid
Not Available
Glucuronide fusidic acidDetails
Fusidic Acid
Not Available
Hydroxy fusidic acidDetails
Route of eliminationNot Available
Half lifeApproximately 5 to 6 hours in adults.
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9691
Blood Brain Barrier+0.7909
Caco-2 permeable-0.6089
P-glycoprotein substrateSubstrate0.8165
P-glycoprotein inhibitor INon-inhibitor0.6004
P-glycoprotein inhibitor IIInhibitor0.7848
Renal organic cation transporterNon-inhibitor0.8424
CYP450 2C9 substrateNon-substrate0.8218
CYP450 2D6 substrateNon-substrate0.9349
CYP450 3A4 substrateSubstrate0.798
CYP450 1A2 substrateNon-inhibitor0.9337
CYP450 2C9 inhibitorNon-inhibitor0.8834
CYP450 2D6 inhibitorNon-inhibitor0.9544
CYP450 2C19 inhibitorNon-inhibitor0.9347
CYP450 3A4 inhibitorNon-inhibitor0.76
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.819
Ames testNon AMES toxic0.8305
CarcinogenicityNon-carcinogens0.9508
BiodegradationNot ready biodegradable0.9753
Rat acute toxicity3.5929 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9403
hERG inhibition (predictor II)Non-inhibitor0.7564
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Creamtopical2 %
Tabletoral250 mg
Creamtopical
Dressingtopical2 %
Kitintravenous
Suspensionoral246 mg
Ointmenttopical2 %
Dropsophthalmic1 %
Prices
Unit descriptionCostUnit
Fucidin 2 % Cream0.66USD g
Fucidin 2 % Ointment0.66USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point192.5 °CPhysProp
pKa5.35MERCK INDEX (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.00521 mg/mLALOGPS
logP4.97ALOGPS
logP4.42ChemAxon
logS-5ALOGPS
pKa (Strongest Acidic)4.66ChemAxon
pKa (Strongest Basic)-0.2ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area104.06 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity144.12 m3·mol-1ChemAxon
Polarizability59.77 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Vanangamudi Subramaniam Sulur, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Haridas Sankar, Selvaraj Balkrishnan, " PROCESS TO MAKE FUSIDIC ACID CREAM." U.S. Patent US20110301138, issued December 08, 2011.

US20110301138
General ReferencesNot Available
External Links
ATC CodesJ01XC01D06AX01D09AA02S01AA13
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Fusidic Acid.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Fusidic Acid.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Fusidic Acid.
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Fusidic Acid.
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Fusidic Acid.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Fusidic Acid.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Fusidic Acid.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Fusidic Acid.
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Fusidic Acid.
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Fusidic Acid.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Fusidic Acid.
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Fusidic Acid.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Fusidic Acid.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Fusidic Acid.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Fusidic Acid.
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Fusidic Acid.
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Fusidic Acid.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Fusidic Acid.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Fusidic Acid.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Fusidic Acid.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Fusidic Acid.
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Fusidic Acid.
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Fusidic Acid.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fusidic Acid.
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Fusidic Acid.
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Fusidic Acid.
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Fusidic Acid.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fusidic Acid.
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Fusidic Acid.
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Fusidic Acid.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Fusidic Acid.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Fusidic Acid.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Fusidic Acid.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Fusidic Acid.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Fusidic Acid.
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Fusidic Acid.
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Fusidic Acid.
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Fusidic Acid.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Fusidic Acid.
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Fusidic Acid.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Fusidic Acid.
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Fusidic Acid.
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Fusidic Acid.
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Fusidic Acid.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Fusidic Acid.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Fusidic Acid.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Fusidic Acid.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Fusidic Acid.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fusidic Acid.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Fusidic Acid.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Fusidic Acid.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Fusidic Acid.
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Fusidic Acid.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Fusidic Acid.
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Fusidic Acid.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Fusidic Acid.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Fusidic Acid.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Fusidic Acid.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Fusidic Acid.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Fusidic Acid.
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Fusidic Acid.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Fusidic Acid.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Fusidic Acid.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Fusidic Acid.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Fusidic Acid.
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Fusidic Acid.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Fusidic Acid.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Fusidic Acid.
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Fusidic Acid.
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Fusidic Acid.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Fusidic Acid.
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Fusidic Acid.
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Fusidic Acid.
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Fusidic Acid.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Fusidic Acid.
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Fusidic Acid.
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Fusidic Acid.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Fusidic Acid.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Fusidic Acid.
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Fusidic Acid.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Fusidic Acid.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Fusidic Acid.
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Fusidic Acid.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Fusidic Acid.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Fusidic Acid.
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Fusidic Acid.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Fusidic Acid.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Fusidic Acid.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Fusidic Acid.
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Fusidic Acid.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Fusidic Acid.
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Fusidic Acid.
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Fusidic Acid.
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Fusidic Acid.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Fusidic Acid.
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Fusidic Acid.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Fusidic Acid.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Fusidic Acid.
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Fusidic Acid.
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Fusidic Acid.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Fusidic Acid.
CocaineThe serum concentration of Cocaine can be increased when it is combined with Fusidic Acid.
CodeineThe serum concentration of Codeine can be increased when it is combined with Fusidic Acid.
Coenzyme Q10The risk or severity of adverse effects can be increased when Fusidic Acid is combined with Coenzyme Q10.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Fusidic Acid.
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Fusidic Acid.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Fusidic Acid.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Fusidic Acid.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Fusidic Acid.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Fusidic Acid.
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Fusidic Acid.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Fusidic Acid.
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Fusidic Acid.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Fusidic Acid.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Fusidic Acid.
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Fusidic Acid.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Fusidic Acid.
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Fusidic Acid.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Fusidic Acid.
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Fusidic Acid.
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Fusidic Acid.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Fusidic Acid.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Fusidic Acid.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Fusidic Acid.
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Fusidic Acid.
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Fusidic Acid.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Fusidic Acid.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Fusidic Acid.
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Fusidic Acid.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Fusidic Acid.
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Fusidic Acid.
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Fusidic Acid.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Fusidic Acid.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Fusidic Acid.
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Fusidic Acid.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Fusidic Acid.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Fusidic Acid.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Fusidic Acid.
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Fusidic Acid.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Fusidic Acid.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Fusidic Acid.
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Fusidic Acid.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fusidic Acid.
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Fusidic Acid.
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Fusidic Acid.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Fusidic Acid.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Fusidic Acid.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Fusidic Acid.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Fusidic Acid.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Fusidic Acid.
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Fusidic Acid.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Fusidic Acid.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Fusidic Acid.
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Fusidic Acid.
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Fusidic Acid.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Fusidic Acid.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Fusidic Acid.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Fusidic Acid.
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Fusidic Acid.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Fusidic Acid.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Fusidic Acid.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Fusidic Acid.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Fusidic Acid.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Fusidic Acid.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Fusidic Acid.
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Fusidic Acid.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Fusidic Acid.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Fusidic Acid.
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Fusidic Acid.
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Fusidic Acid.
EstroneThe serum concentration of Estrone can be increased when it is combined with Fusidic Acid.
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Fusidic Acid.
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Fusidic Acid.
EthanolThe serum concentration of Ethanol can be increased when it is combined with Fusidic Acid.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fusidic Acid.
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Fusidic Acid.
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Fusidic Acid.
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Fusidic Acid.
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Fusidic Acid.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Fusidic Acid.
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Fusidic Acid.
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Fusidic Acid.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Fusidic Acid.
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Fusidic Acid.
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Fusidic Acid.
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Fusidic Acid.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Fusidic Acid.
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Fusidic Acid.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Fusidic Acid.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Fusidic Acid.
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Fusidic Acid.
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Fusidic Acid.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Fusidic Acid.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Fusidic Acid.
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Fusidic Acid.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Fusidic Acid.
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Fusidic Acid.
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Fusidic Acid.
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Fusidic Acid.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Fusidic Acid.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Fusidic Acid.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Fusidic Acid.
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Fusidic Acid.
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Fusidic Acid.
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Fusidic Acid.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Fusidic Acid.
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Fusidic Acid.
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Fusidic Acid.
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Fusidic Acid.
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Fusidic Acid.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Fusidic Acid.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Fusidic Acid.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Fusidic Acid.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Fusidic Acid.
HalothaneThe serum concentration of Halothane can be increased when it is combined with Fusidic Acid.
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Fusidic Acid.
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Fusidic Acid.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Fusidic Acid.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Fusidic Acid.
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Fusidic Acid.
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Fusidic Acid.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Fusidic Acid.
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Fusidic Acid.
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Fusidic Acid.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Fusidic Acid.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Fusidic Acid.
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Fusidic Acid.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Fusidic Acid.
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Fusidic Acid.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Fusidic Acid.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Fusidic Acid.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Fusidic Acid.
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Fusidic Acid.
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Fusidic Acid.
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Fusidic Acid.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Fusidic Acid.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Fusidic Acid.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Fusidic Acid.
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Fusidic Acid.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Fusidic Acid.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Fusidic Acid.
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Fusidic Acid.
KetamineThe serum concentration of Ketamine can be increased when it is combined with Fusidic Acid.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Fusidic Acid.
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Fusidic Acid.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Fusidic Acid.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Fusidic Acid.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Fusidic Acid.
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Fusidic Acid.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Fusidic Acid.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Fusidic Acid.
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Fusidic Acid.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Fusidic Acid.
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Fusidic Acid.
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Fusidic Acid.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Fusidic Acid.
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Fusidic Acid.
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Fusidic Acid.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Fusidic Acid.
LisurideThe serum concentration of Lisuride can be increased when it is combined with Fusidic Acid.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Fusidic Acid.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Fusidic Acid.
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Fusidic Acid.
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Fusidic Acid.
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Fusidic Acid.
LosartanThe serum concentration of Losartan can be increased when it is combined with Fusidic Acid.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Fusidic Acid.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Fusidic Acid.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Fusidic Acid.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Fusidic Acid.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Fusidic Acid.
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Fusidic Acid.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Fusidic Acid.
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Fusidic Acid.
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Fusidic Acid.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Fusidic Acid.
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Fusidic Acid.
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Fusidic Acid.
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Fusidic Acid.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Fusidic Acid.
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Fusidic Acid.
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Fusidic Acid.
MevastatinThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Mevastatin.
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Fusidic Acid.
MianserinThe serum concentration of Mianserin can be increased when it is combined with Fusidic Acid.
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Fusidic Acid.
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Fusidic Acid.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Fusidic Acid.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Fusidic Acid.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Fusidic Acid.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Fusidic Acid.
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Fusidic Acid.
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Fusidic Acid.
MorphineThe serum concentration of Morphine can be increased when it is combined with Fusidic Acid.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Fusidic Acid.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fusidic Acid.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Fusidic Acid.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Fusidic Acid.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Fusidic Acid.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Fusidic Acid.
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Fusidic Acid.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Fusidic Acid.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Fusidic Acid.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Fusidic Acid.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Fusidic Acid.
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Fusidic Acid.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Fusidic Acid.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Fusidic Acid.
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Fusidic Acid.
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Fusidic Acid.
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Fusidic Acid.
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Fusidic Acid.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Fusidic Acid.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Fusidic Acid.
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Fusidic Acid.
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Fusidic Acid.
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Fusidic Acid.
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Fusidic Acid.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Fusidic Acid.
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Fusidic Acid.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Fusidic Acid.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Fusidic Acid.
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Fusidic Acid.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Fusidic Acid.
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Fusidic Acid.
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Fusidic Acid.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Fusidic Acid.
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Fusidic Acid.
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Fusidic Acid.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Fusidic Acid.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Fusidic Acid.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Fusidic Acid.
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Fusidic Acid.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Fusidic Acid.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Fusidic Acid.
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Fusidic Acid.
PergolideThe serum concentration of Pergolide can be increased when it is combined with Fusidic Acid.
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Fusidic Acid.
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Fusidic Acid.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Fusidic Acid.
PethidineThe serum concentration of Pethidine can be increased when it is combined with Fusidic Acid.
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Fusidic Acid.
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Fusidic Acid.
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Fusidic Acid.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Fusidic Acid.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Fusidic Acid.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fusidic Acid.
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Fusidic Acid.
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Fusidic Acid.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Fusidic Acid.
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Fusidic Acid.
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Fusidic Acid.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Fusidic Acid.
PitavastatinThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Pitavastatin.
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Fusidic Acid.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Fusidic Acid.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Fusidic Acid.
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Fusidic Acid.
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Fusidic Acid.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Fusidic Acid.
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Fusidic Acid.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Fusidic Acid.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Fusidic Acid.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Fusidic Acid.
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Fusidic Acid.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Fusidic Acid.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Fusidic Acid.
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Fusidic Acid.
PromazineThe serum concentration of Promazine can be increased when it is combined with Fusidic Acid.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Fusidic Acid.
PropofolThe serum concentration of Propofol can be increased when it is combined with Fusidic Acid.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Fusidic Acid.
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Fusidic Acid.
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Fusidic Acid.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Fusidic Acid.
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Fusidic Acid.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Fusidic Acid.
QuinineThe serum concentration of Quinine can be increased when it is combined with Fusidic Acid.
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Fusidic Acid.
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Fusidic Acid.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Fusidic Acid.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Fusidic Acid.
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Fusidic Acid.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Fusidic Acid.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Fusidic Acid.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Fusidic Acid.
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Fusidic Acid.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Fusidic Acid.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Fusidic Acid.
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Fusidic Acid.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Fusidic Acid.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Fusidic Acid.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Fusidic Acid.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Fusidic Acid.
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Fusidic Acid.
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Fusidic Acid.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Fusidic Acid.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Fusidic Acid.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Fusidic Acid.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Fusidic Acid.
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Fusidic Acid.
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Fusidic Acid.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Fusidic Acid.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Fusidic Acid.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Fusidic Acid.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Fusidic Acid.
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Fusidic Acid.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Fusidic Acid.
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Fusidic Acid.
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Fusidic Acid.
SertralineThe serum concentration of Sertraline can be increased when it is combined with Fusidic Acid.
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Fusidic Acid.
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Fusidic Acid.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Fusidic Acid.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Fusidic Acid.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Fusidic Acid.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Fusidic Acid.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Fusidic Acid.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Fusidic Acid.
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Fusidic Acid.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Fusidic Acid.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Fusidic Acid.
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Fusidic Acid.
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Fusidic Acid.
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Fusidic Acid.
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Fusidic Acid.
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Fusidic Acid.
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Fusidic Acid.
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Fusidic Acid.
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Fusidic Acid.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Fusidic Acid.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Fusidic Acid.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Fusidic Acid.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Fusidic Acid.
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Fusidic Acid.
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Fusidic Acid.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Fusidic Acid.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Fusidic Acid.
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Fusidic Acid.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Fusidic Acid.
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Fusidic Acid.
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Fusidic Acid.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Fusidic Acid.
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Fusidic Acid.
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Fusidic Acid.
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Fusidic Acid.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Fusidic Acid.
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Fusidic Acid.
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Fusidic Acid.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Fusidic Acid.
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Fusidic Acid.
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Fusidic Acid.
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Fusidic Acid.
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Fusidic Acid.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Fusidic Acid.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Fusidic Acid.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Fusidic Acid.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Fusidic Acid.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Fusidic Acid.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Fusidic Acid.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Fusidic Acid.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Fusidic Acid.
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Fusidic Acid.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Fusidic Acid.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Fusidic Acid.
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Fusidic Acid.
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Fusidic Acid.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Fusidic Acid.
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Fusidic Acid.
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Fusidic Acid.
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Fusidic Acid.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Fusidic Acid.
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Fusidic Acid.
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Fusidic Acid.
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Fusidic Acid.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Fusidic Acid.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Fusidic Acid.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Fusidic Acid.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Fusidic Acid.
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Fusidic Acid.
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Fusidic Acid.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Fusidic Acid.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Fusidic Acid.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Fusidic Acid.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Fusidic Acid.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Fusidic Acid.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Fusidic Acid.
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Fusidic Acid.
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Fusidic Acid.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Fusidic Acid.
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Fusidic Acid.
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Fusidic Acid.
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Fusidic Acid.
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Fusidic Acid.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Fusidic Acid.
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Fusidic Acid.
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Fusidic Acid.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Fusidic Acid.
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Fusidic Acid.
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Fusidic Acid.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Fusidic Acid.
Food Interactions
  • Take with food to reduce irritation.

Targets

Kind
Protein
Organism
Thermus thermophilus
Pharmacological action
yes
Actions
inhibitor
General Function:
Translation elongation factor activity
Specific Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA an...
Gene Name:
fusA
Uniprot ID:
P13551
Molecular Weight:
76878.69 Da
References
  1. Lannergard J, Norstrom T, Hughes D: Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 2009 May;53(5):2059-65. doi: 10.1128/AAC.00871-08. Epub 2009 Mar 16. [PubMed:19289529 ]
  2. Chen Y, Koripella RK, Sanyal S, Selmer M: Staphylococcus aureus elongation factor G--structure and analysis of a target for fusidic acid. FEBS J. 2010 Sep;277(18):3789-803. doi: 10.1111/j.1742-4658.2010.07780.x. Epub 2010 Aug 13. [PubMed:20718859 ]
  3. Gao YG, Selmer M, Dunham CM, Weixlbaumer A, Kelley AC, Ramakrishnan V: The structure of the ribosome with elongation factor G trapped in the posttranslocational state. Science. 2009 Oct 30;326(5953):694-9. doi: 10.1126/science.1179709. [PubMed:19833919 ]
Kind
Protein
Organism
Salmonella typhi
Pharmacological action
unknown
Actions
inhibitor
General Function:
Chloramphenicol o-acetyltransferase activity
Specific Function:
This enzyme is an effector of chloramphenicol resistance in bacteria.
Gene Name:
cat
Uniprot ID:
P62580
Molecular Weight:
25663.08 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Murray IA, Cann PA, Day PJ, Derrick JP, Sutcliffe MJ, Shaw WV, Leslie AG: Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site. J Mol Biol. 1995 Dec 15;254(5):993-1005. [PubMed:7500366 ]
  4. Bennett AD, Shaw WV: Resistance to fusidic acid in Escherichia coli mediated by the type I variant of chloramphenicol acetyltransferase. A plasmid-encoded mechanism involving antibiotic binding. Biochem J. 1983 Oct 1;215(1):29-38. [PubMed:6354181 ]
  5. Day PJ, Murray IA, Shaw WV: Properties of hybrid active sites in oligomeric proteins: kinetic and ligand binding studies with chloramphenicol acetyltransferase trimers. Biochemistry. 1995 May 16;34(19):6416-22. [PubMed:7756272 ]
Kind
Protein
Organism
Escherichia coli
Pharmacological action
unknown
Actions
inhibitor
General Function:
Chloramphenicol o-acetyltransferase activity
Specific Function:
This enzyme is an effector of chloramphenicol resistance in bacteria.
Gene Name:
cat3
Uniprot ID:
P00484
Molecular Weight:
24993.32 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Murray IA, Cann PA, Day PJ, Derrick JP, Sutcliffe MJ, Shaw WV, Leslie AG: Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site. J Mol Biol. 1995 Dec 15;254(5):993-1005. [PubMed:7500366 ]
  4. Bennett AD, Shaw WV: Resistance to fusidic acid in Escherichia coli mediated by the type I variant of chloramphenicol acetyltransferase. A plasmid-encoded mechanism involving antibiotic binding. Biochem J. 1983 Oct 1;215(1):29-38. [PubMed:6354181 ]
  5. Day PJ, Murray IA, Shaw WV: Properties of hybrid active sites in oligomeric proteins: kinetic and ligand binding studies with chloramphenicol acetyltransferase trimers. Biochemistry. 1995 May 16;34(19):6416-22. [PubMed:7756272 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Bode KA, Donner MG, Leier I, Keppler D: Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8. [PubMed:12106615 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Bode KA, Donner MG, Leier I, Keppler D: Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8. [PubMed:12106615 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23