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Displaying drugs 51 - 75 of 191 in total
Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively...
Approved
Matched Iupac: … (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid …
Matched Description: … for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes. ... (heart attack, stroke, coronary revascularization, and coronary death) for every 1 mmol/L reduction ... event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular events …
Matched Salts cas: … 147526-32-7 ... 956116-90-8 ... 574705-92-3
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Cytochrome P-450 Substrates ... P-glycoprotein substrates ... Cytochrome P-450 CYP2C8 Substrates ... Cytochrome P-450 CYP2C9 Substrates …
Matched Products: … Trolise 4 mg Filmtabletten ... Trolise 1 mg Filmtabletten ... ALIPZA 4 MG FILM KAPLI TABLET, 90 ADET …
Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neuroblastoma - it is widely expressed across and within...
Approved
Matched Description: … (IL-2), and 13-cis-retinoic acid (RA). ... subject to antigen loss. ... humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
Approved
Matched Synonyms: … 1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane ... 1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine ... 3-(p-chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine …
Matched Iupac: … [3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine …
Matched Description: … A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. ... One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and
Matched Salts cas: … 113-92-8 ... 25387-68-2 ... 1405-56-7 ... 56343-98-7
Matched Mixtures name: … A-FERİN 1 MG +160 MG/5 ML PEDİYATRİK ŞURUP, 100 ML ... A-FERİN PLUS 1 MG +15 MG+160 MG/5 ML PEDİYATRİK ŞURUP,100 ML ... TYLOL HOT 500 MG+60 MG+4 MG/20 G TEK KULLANIMLIK ORAL ÇÖZELTİ HAZIRLAMAK İÇİN TOZ, 6 POŞET …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Cytochrome P-450 Substrates ... Cytochrome P-450 CYP2D6 Inhibitors ... Cytochrome P-450 CYP3A Substrates ... Cytochrome P-450 CYP2D6 Substrates …
Matched Products: … ALERFIN 2 MG/5 ML ORAL ÇÖZELTI, 1 ŞIŞE ... CLORFENIRAMINA JARABE 2 MG / 5 ML ... CLORFENIRAMINA MALEATO 2 MG / 5 ML …
Raxibacumab is a human IgG1λ monoclonal antibody that binds the protective antigen (PA) component of B. anthracis toxin. Raxibacumab has a molecular weight of approximately 146 kilodaltons. Raxibacumab is produced by recombinant DNA technology in a murine cell expression system. FDA approved on December 14, 2012.
Approved
Matched Description: … Raxibacumab is a human IgG1λ monoclonal antibody that binds the protective antigen (PA) component of ... Raxibacumab has a molecular weight of approximately 146 kilodaltons. ... Raxibacumab is produced by recombinant DNA technology in a murine cell expression system. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins ... Anthrax Protective Antigen-directed Antibody ... Anthrax Protective Antigen-directed Antibody Interactions …
Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which...
Approved
Investigational
Matched Synonyms: … Interferon gamma 1-b …
Matched Description: … The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray ... et. al. and not specifically interferon gamma 1b. ... containing the DNA which encodes for the human protein. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins ... Cytochrome P-450 CYP1A2 Inhibitors ... Cytochrome P-450 Enzyme Inhibitors ... Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) …
Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approval on 25 March 2011.
Approved
Matched Description: … Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 ... [A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. ... (CTLA-4). …
Matched Categories: … Immunoglobulin G ... CTLA-4-directed Blocking Antibody ... CTLA-4-directed Antibody Interactions ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … YERVOY®5 MG /ML SOLUCION INYECTABLE PARA INFUSION INTRAVENOSA ... YERVOY 200MG/40ML IV INFUZYONLUK ÇOZELTI KONSANTRESI ICEREN FLAKON, 1 ADET ... YERVOY 50MG/10ML IV INFUZYONLUK ÇOZELTI KONSANTRESI ICEREN FLAKON, 1 ADET …
Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).
Approved
Investigational
Matched Description: … Muromonab is 93% monomeric immune globulin G type 2a (IgG2a). ... More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) ... receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. …
Matched Categories: … Immunoglobulin G ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Orthoclone Okt 3 Sterile Solution IV 1mg/ml …
Pemirolast potassium is a slightly yellow powder that is soluble in water. It is a mast cell stabilizer that acts as an antiallergic agent. As an ophthalmic aqueous sterile solution, pemirolast is used for the prevention of itching of the eyes caused by allergies such as hay fever, and allergic...
Approved
Investigational
Matched Iupac: … 9-methyl-3-(2H-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one …
Matched Description: … pemirolast is used for the prevention of itching of the eyes caused by allergies such as hay fever, and ... It is a mast cell stabilizer that acts as an antiallergic agent. ... Pemirolast potassium is a slightly yellow powder that is soluble in water. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
The Moderna COVID-19 Vaccine (mRNA-1273) is a novel mRNA-based vaccine encapsulated in a lipid nanoparticle that encodes for a full-length pre-fusion stabilized spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease caused by the novel coronavirus, SARS-CoV-2, leading...
Approved
Investigational
Matched Synonyms: … MRNA-1273 SARS-COV-2
Matched Description: … in which 45 subjects received two intramuscular doses (on days 1 and 29). ... , SARS-CoV-2, leading to a respiratory illness alongside other complications. ... coronavirus 2 (SARS-CoV-2). …
Matched Mixtures name: … Spikevax Bivalent (original / Omicron Ba.4/5) …
Pimecrolimus is an immunomodulating agent that was first marketed by Novartis under the trade name Elidel. It is now promoted in Canada by Galderma since early 2007. It is currently available as a topic cream used in the treatment of atopic dermatitis (eczema).
Approved
Investigational
Matched Iupac: … (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-[(1E)-1-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]prop ... -1-en-2-yl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo …
Matched Description: … It is currently available as a topic cream used in the treatment of atopic dermatitis (eczema). …
Matched Categories: … Skin and Mucous Membrane Agents ... Cytochrome P-450 Substrates ... Cytochrome P-450 CYP3A Substrates ... Cytochrome P-450 CYP3A4 Substrates …
Matched Products: … ELIDEL %1 KREM, 15 G ... ELIDEL %1 KREM, 60 G ... ELIDEL % 1 KREM, 30 G
Efanesoctocog alfa (BIVV001) is a recombinant factor VIII (FVIII) analogue fusion protein used for the routine prophylaxis, perioperative management of bleeding and on-demand treatment and control of bleeding episodes in patients with hemophilia A. The use of FVIII replacement products is beneficial in patients with hemophilia A; however, their quality...
Approved
Investigational
Matched Description: … To extend the half-life of FVIII, efanesoctocog alfa is fused to dimeric Fc, a D'D3 domain of VWF, and ... routine prophylaxis, perioperative management of bleeding and on-demand treatment and control of bleeding ... VIII therapy for hemophilia A. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences , [FDA label]. It was originally...
Approved
Matched Description: … CD20 antigen found on the surface of normal and malignant B lymphocytes. ... sequences and human constant region sequences [A40017], [FDA label]. ... Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the …
Matched Categories: … Amino Acids, Peptides, and Proteins ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … MABTHERA 1400 MG/11,7 ML SC ENJEKSIYON IÇIN ÇÖZELTI, 1 ADET ... Rituxan Sc ... RİXATHON 100MG/10ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 3 ADET …
Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and...
Approved
Investigational
Matched Description: … Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains ... Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, ... which is found on the surface of normal and malignant B lymphocytes. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently,...
Approved
Investigational
Matched Iupac: … {[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2H,3H,4H-pyrido ... [3,2-b][1,4]oxazin-4-yl]methoxy}phosphonic acid …
Matched Description: … Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune ... Recently, fostamatinib has been identified as a potential therapeutic for controlling acute respiratory …
Matched Salts cas: … 914295-16-2
Matched Categories: … Blood and Blood Forming Organs ... Heterocyclic Compounds, 1-Ring ... Phosphodiesterase 5 Inhibitors ... Cytochrome P-450 Substrates ... Cytochrome P-450 CYP3A Inhibitors …
Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-humanized CD20 antibodies such as rituximab, ocrelizumab is...
Approved
Investigational
Matched Description: … B-cells that express the CD20 antigen. ... leads to neurological disabilities and a significantly reduced quality of life. ... [L1199] In phase 3 clinical trials of patients with PPMS, treatment with ocrelizumab led to lower clinical …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … OCREVUS 300 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 2 ADET ... OCREVUS 300 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Fluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various inflammatory indications[FDA Label] . Fluticasone furoate was first approved in 2007 .
Approved
Matched Iupac: … ,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl furan ... -2-carboxylate ... (1R,2R,3aS,3bS,5S,9aS,9bR,10S,11aS)-5,9b-difluoro-1-{[(fluoromethyl)sulfanyl]carbonyl}-10-hydroxy-2,9a …
Matched Description: … Fluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various …
Matched Mixtures name: … RELVAR ELLIPTA 100/25 MCG KULLANIMA HAZIR INHALASYON TOZU ,3 X 30 ... Fluticasone Furoate and Vilanterol ... Fluticasone Furoate and Vilanterol …
Matched Categories: … vilanterol and fluticasone furoate ... vilanterol, umeclidinium bromide and fluticasone furoate ... P-glycoprotein inducers ... P-glycoprotein substrates ... Cytochrome P-450 Substrates …
Approved
Vet approved
Matched Synonyms: … 11β,21-dihydroxy-17α-butyryloxy-4-pregnene-3,20-dione …
Matched Iupac: … (1R,3aS,3bS,9aR,9bS,10S,11aS)-10-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H ... ,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl butanoate …
Matched Categories: … Hydrocortisone and derivatives ... hydrocortisone butyrate and antiseptics ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Cytochrome P-450 Substrates ... Cytochrome P-450 CYP2C8 Inducers …
Matched Products: … LOCODERM %0.1 KREM, 15 G ... LOCODERM %0.1 MERHEM, 15 G ... LOCODERM %0.1 KREM, 30 G
Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,...
Approved
Matched Iupac: … (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic …
Matched Description: … death) for every 1 mmol/L reduction in LDL without any significant side effects or risks. ... heterocyclic core unit and a 3,5-dihydroxypentanoyl side chain identical to its parent compound. ... reduction in LDL levels and CVD risk. …
Matched Salts cas: … 134523-03-8
Matched Mixtures name: … TIAZOMET ® A 40/10 TABLETAS ... ./5 มก./5 มก. ... Triveram 10 mg/5 mg/5 mg Filmtabletten …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... atorvastatin and ezetimibe ... atorvastatin and amlodipine ... atorvastatin and perindopril ... atorvastatin, amlodipine and ramipril …
Matched Products: … ATORVASTATINA P-CARE ... Sortis 5 mg Kautabletten …
Approved
Vet approved
Matched Iupac: … ,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}phosphonic acid ... {2-[(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H …
Matched Salts cas: … 6000-74-4
Matched Categories: … Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Cytochrome P-450 Substrates ... Cytochrome P-450 CYP2C8 Inducers ... Cytochrome P-450 CYP3A Substrates …
Ibalizumab (also known as ibalizumab-uiyk and formerly known as TNX-355) is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells, preventing HIV particle entry into the lymphocytes. It is an advanced and current antibody in development for the treatment of HIV/AIDS. It has been developed...
Approved
Investigational
Matched Description: … Ibalizumab (also known as _ibalizumab-uiyk_ and formerly known as TNX-355) is a monoclonal antibody that ... the FDA approved the administration of Trogarzo (ibalizumab-uiyk) by intravenous push, allowing for a ... It has been developed by Taimed biologics and Theratechnologies [L1558, L1554]. …
Matched Categories: … Human Immunodeficiency Virus 1 Post-attachment Fusion Inhibitor ... Amino Acids, Peptides, and Proteins ... HIV 1 Post-attachment Fusion Inhibitors …
Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and complementarity-determining regions from a...
Approved
Investigational
Matched Description: … The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and ... Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. ... complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … MABCAMPATH INF SOL ICIN 30 MG/ML KONS 1 ML 3 FLK (10 MG/ML KONSANTRE 3 AMP) ... LEMTRADA 12 MG /1.2 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor...
Approved
Investigational
Matched Iupac: … -3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo ... (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy …
Matched Description: … attention especially in cancer, as mTOR signalling pathways are constitutively activated in many types of human ... Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces ... primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR), which is a
Matched Categories: … Sirolimus and Prodrugs ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Antineoplastic and Immunomodulating Agents ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Matched Products: … P-HYSPLAN ... RAPAMUNE TABLET 2 mg ... RAPAMUNE TABLET 1 mg …
Imelasomeran was first approved in Canada on September 1, 2022, as one-half of Moderna's Spikevax Bivalent COVID-19 mRNA vaccine. It encodes for the viral spike protein of the Omicron BA.1 variant of SARS-CoV-2, a particularly infectious variant of concern first documented in 2021.
Approved
Investigational
Matched Description: … [L45320] It encodes for the viral spike protein of the Omicron BA.1 variant of SARS-CoV-2, a particularly ... Imelasomeran was first approved in Canada on September 1, 2022, as one-half of Moderna's Spikevax Bivalent …
Choline C 11 Injection is a radioactive diagnostic agent for positron emission tomography (PET) imaging of pat ients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized tomography (CT) or magnetic resonance imaging.
Approved
Matched Iupac: … (2-hydroxyethyl)((11C)methyl)dimethylazanium …
Matched Description: … Choline C 11 Injection is a radioactive diagnostic agent for positron emission tomography (PET) imaging ... of pat ients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized …
Approved
Investigational
Vet approved
Matched Iupac: … ,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl 3-cyclopentylpropanoate ... 2-[(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H …
Matched Categories: … Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Cytochrome P-450 Substrates ... Cytochrome P-450 CYP2C8 Inducers ... Cytochrome P-450 CYP3A Substrates …
Displaying drugs 51 - 75 of 191 in total