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Displaying drugs 176 - 200 of 1931 in total

Elvitegravir

Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome and thereby blocks the formation of the...
Approved
Matched Description: … Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI ... Elvitegravir was first licensed from Japan Tobacco in 2008 and developed by Gilead Sciences. ... thereby blocks the formation of the HIV-1 provirus and resulting propagation of the viral infection. …
Matched Categories: … Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor ... emtricitabine, tenofovir disoproxil, elvitegravir and cobicistat ... emtricitabine, tenofovir alafenamide, elvitegravir and cobicistat …

Sebelipase alfa

The lysosomal acid lipase (LAL) enzyme is found in lysosomes and is primarily responsible for the metabolism of lipids, and its absence or deficiency results in the accumulation of lipids in various organs. This lipid accumulation can lead to end-organ damage in the form of liver dysfunction or malabsorption secondary...
Approved
Investigational
Matched Description: … [L39337] Sebelipase alfa is a recombinant form LAL approved for the treatment of LAL deficiency. ... It was first approved by both the FDA and EMA in 2015 and is marketed under the brand name Kanuma (Alexion ... of lipids, and its absence or deficiency results in the accumulation of lipids in various organs. …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …

Eladocagene exuparvovec

Eladocagene exuparvovec is a recombinant adeno-associated virus-2 (AAV2)-based gene therapy that expresses human aromatic L-amino acid decarboxylase (AADC), and it is used to treat AADC deficiency, a fatal and rare genetic disorder that causes severe disability in pediatric patients.[L43642,L43672] Patients with AADC have mutations in the dopa decarboxylase (DDC) gene...
Approved
Investigational
Matched Description: … human aromatic L-amino acid decarboxylase (AADC), and it is used to treat AADC deficiency, a fatal and ... Eladocagene exuparvovec is a recombinant adeno-associated virus-2 (AAV2)-based gene therapy that expresses ... neurotransmitter production, decrease neurotransmitter catabolism via monoamine oxidase (MAO) inhibition and …

Ranibizumab

Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment directed against human vascular endothelial growth factor A (VEGF-A), which is a glycoprotein implicated in the pathophysiology of age-related macular degeneration.[A2301, L38978] Ranibizumab is used to treat various ocular disorders with abnormal growth of blood vessels, such as neovascular...
Approved
Matched Description: … Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment directed against ... human vascular endothelial growth factor A (VEGF-A), which is a glycoprotein implicated in the pathophysiology ... , and Health Canada respectively. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Tiludronic acid

Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to etidronic acid and clodronic acid.[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone....
Approved
Investigational
Vet approved
Matched Description: … thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and ... A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and …
Matched Categories: … Drugs Affecting Bone Structure and Mineralization …

Dipivefrin

Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).
Approved
Matched Categories: … Antiglaucoma Preparations and Miotics …

Ramucirumab

Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stimulated receptor phosphorylation and downstream ligand-induced proliferation, permeability,...
Approved
Investigational
Matched Description: … , and migration of human endothelial cells. ... Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor ... By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Ocrelizumab

Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-humanized CD20 antibodies such as rituximab, ocrelizumab is...
Approved
Investigational
Matched Description: … [L42895] It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets ... inflammatory, autoimmune disease of the central nervous system that leads to neurological disabilities and ... Health Canada in August 2017, making the drug the first available treatment for PPMS in both the US and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Infliximab

Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions . Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory cytokine involved in...
Approved
Matched Description: … composed of human constant (75%) and murine variable (25%) regions [A31469]. ... Infliximab is produced by a recombinant cell line cultured by continuous perfusion. ... Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Aprepitant

Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance...
Approved
Investigational
Matched Description: … Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. ... delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy ... targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV). …
Matched Categories: … Aprepitant and Prodrugs ... Alimentary Tract and Metabolism ... Antiemetics and Antinauseants …

Netupitant

Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug is marketed by Eisai...
Approved
Investigational
Matched Description: … The combination drug is marketed by Eisai Inc. and Helsinn Therapeutics (U.S.) ... approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and ... delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy …
Matched Categories: … Netupitant and prodrug …

Seractide acetate

Seractide acetate is the acetate salt of full length human corticotropin.
Approved
Matched Description: … Seractide acetate is the acetate salt of full length human corticotropin. …

Fidanacogene elaparvovec

Fidanacogene elaparvovec is a liver-specific adeno-associated virus (AAV) vector containing a codon-optimized human coagulation FIX gene that was investigated as a potential treatment for hemophilia B. Hemophilia B is a rare X-linked genetic disorder characterized by abnormal coagulation due to dysfunctional coagulation factor IX with a male incidence estimated to...
Approved
Investigational
Matched Description: … Fidanacogene elaparvovec is a liver-specific adeno-associated virus (AAV) vector containing a codon-optimized human ... the level of factor IX activity in the blood plasma, ranging from increased bleeding after injuries and ... surgical operations to spontaneous bleeding, hemorrhages in soft tissues or joints, and severe subcutaneous …

Molindone

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate...
Approved
Matched Description: … An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment ... It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. ... Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively …

Albiglutide

Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on April 15, 2014 by the...
Approved
Matched Description: … It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). ... It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. …
Matched Categories: … Recombinant Proteins ... Alimentary Tract and Metabolism ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated)

Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) is a vaccine that is used in the prophylaxis of Pertussis (whooping cough), which is caused by a small Gram-negative coccobacillus that infects the mucosal layers of the human respiratory tract.
Approved
Matched Description: … cough), which is caused by a small Gram-negative coccobacillus that infects the mucosal layers of the human …

Onasemnogene abeparvovec

Onasemnogene abeparvovec is an adeno-associated virus vector-based gene therapy that has been approved by the FDA in May 2019 for the treatment of infant patients (less than 2 years of age) with spinal muscular atrophy (SMA) and a specific mutation in the survival motor neuron 1 (SMN1) gene. SMA is...
Approved
Matched Description: … to debilitating and often fatal muscle weakness. ... for the treatment of infant patients (less than 2 years of age) with spinal muscular atrophy (SMA) and ... complete paralysis of the limbs and permanent dependence on ventilators, has not been evaluated. …
Matched Categories: … Recombinant Proteins ... Cellular and Gene Therapy ... Amino Acids, Peptides, and Proteins …

Fosamprenavir

Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
Approved
Matched Description: … Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease …
Matched Categories: … Amprenavir and Prodrugs …

Retapamulin

Retapamulin, marketed by GlaxoSmithKline as the ointment Altabax, is an antibiotic for skin infections like impetigo. It was approved by the FDA in April 2007.
Approved

Ibalizumab

Ibalizumab (also known as ibalizumab-uiyk and formerly known as TNX-355) is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells, preventing HIV particle entry into the lymphocytes. It is an advanced and current antibody in development for the treatment of HIV/AIDS. It has been developed...
Approved
Investigational
Matched Description: … It has been developed by Taimed biologics and Theratechnologies [L1558, L1554]. ... It is an advanced and current antibody in development for the treatment of HIV/AIDS. ... Ibalizumab (also known as _ibalizumab-uiyk_ and formerly known as TNX-355) is a monoclonal antibody that …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Human Immunodeficiency Virus 1 Post-attachment Fusion Inhibitor …

Lubiprostone

Lubiprostone is a medication used in the management of idiopathic chronic constipation. A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. Activation of these channels promotes the secretion of a chloride-rich fluid that soften...
Approved
Investigational
Matched Description: … promotes the secretion of a chloride-rich fluid that soften the stool, increase gastrointestinal motility, and …
Matched Categories: … Alimentary Tract and Metabolism …

Omidenepag isopropyl

Omidenepag isopropyl is a topical ocular hypotensive agent used to reduce intraocular pressure (IOP) in patients with glaucoma and ocular hypertension. Omidenepag isopropyl is quickly metabolized to its active metabolite, omidenepag, a molecule with high selectivity and agonistic activity towards the prostaglandin E2 (EP2) receptor.[A253263,A253268] Prostanoid FP receptor agonists (FP...
Approved
Investigational
Matched Description: … topical ocular hypotensive agent used to reduce intraocular pressure (IOP) in patients with glaucoma and ... isopropyl is quickly metabolized to its active metabolite, omidenepag, a molecule with high selectivity and ... [A253253] In 2018, omidenepag isopropyl was approved in Japan for the treatment of glaucoma and ocular …

Magnesium gluconate

Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used...
Approved
Investigational
Matched Description: … Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food ... and laxatives) [L2601]. ... It demonstrates the highest oral bioavailability of magnesium salts [L2608] and is used as a mineral …
Matched Mixtures name: … NUTROPLEX LIQUID WITH IRON AND LYSINE …
Matched Categories: … Alimentary Tract and Metabolism …

Fexofenadine

Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H1 receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamines, such as diphenhydramine, which readily bind to off-targets...
Approved
Investigational
Matched Description: … L4269] It is selective for the H1 receptor, carries little-to-no activity at off-targets, and ... [A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a …
Matched Mixtures name: … Allergy and Congestion ... Allergy and Congestion ... Allegra-D Allergy and Congestion …
Matched Products: … Up and Up Allergy Relief ... Berkley and Jensen Allergy Relief ... Up and Up Non Drowsy Allergy Relief …

Metformin

Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin...
Approved
Matched Description: … Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management ... It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and ... [A36559] Metformin was first approved in Canada in 1972,[A36552] and received subsequent FDA approval …
Matched Mixtures name: … DIMEFOR-G ... RANGIMET G ... MELLIMET G TABLETAS …
Matched Categories: … metformin and acarbose ... Alimentary Tract and Metabolism ... metformin and evogliptin ... metformin and gemigliptin ... metformin and linagliptin …
Matched Products: … G-MET G-TABS ... G-MET G-TAB 500 MG ... G-MET G-TAB® 1000 MG …
Displaying drugs 176 - 200 of 1931 in total