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Displaying drugs 126 - 150 of 8922 in total

Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and...
Approved
Matched Synonyms: … 4-isobutylhydratropic acid ... 2-(4-isobutylphenyl)propanoic acid ... α-(4-isobutylphenyl)propionic acid …
Matched Iupac: … 2-[4-(2-methylpropyl)phenyl]propanoic acid …
Matched Description: … [A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development ... Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ ... In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological …
Matched Salts cas: … 79261-49-7 …
Matched Mixtures name: … 7-Select Advil PM ... 7 Select Ibuprofen PM ... Fluconazole 4% / Ibuprofen 2% / Itraconazole 1% / Terbinafine HCl 4% …
Matched Products: … 7 Select Ibuprofen ... 24/7 Life IBUPROFEN ... 7 Select Childrens Ibuprofen …

Probucol

A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
Approved
Investigational
Matched Synonyms: … Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole …
Matched Iupac: … 2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol …

Mupirocin

Mupirocin, formerly termed pseudomonic acid A, is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. Produced by fermentation using the organism Pseudomonas fluorescens, mupirocin is a naturally-occurring antibiotic that displays a broad-specturm activity against many gram-positive bacteria and certain gram-negative...
Approved
Investigational
Vet approved
Matched Synonyms: … 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] …
Matched Iupac: … 9-{[(2E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-{[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl …
Matched Products: … DERMUCOR S …

Enzacamene

Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic chemical UV-B filter. It is used in cosmetic products such as sunscreen to provide skin protection against UV rays. While its effects on the human reproductive system as an endocrine disruptor are being investigated, its use in...
Approved
Matched Synonyms: … 4-MBC ... 4-methylbenzylidene camphor ... 3-(4-methylbenzylidene)camphor …
Matched Iupac: … (3E)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one …
Matched Description: … Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic …
Matched Mixtures name: … Autobronzant SPF 7 ... Anthelios S - Ecran Solaire SPF 30 …

Tiludronic acid

Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to etidronic acid and clodronic acid.[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone....
Approved
Investigational
Vet approved
Matched Iupac: … {[(4-chlorophenyl)sulfanyl](phosphono)methyl}phosphonic acid …
Matched Description: … [A202235] Tiludronic acid was granted FDA approval on 7 March 1997.[L4763] ... Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate …

Isotretinoin

Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the...
Approved
Matched Description: … [L6579] The first isotretinoin-containing product was FDA approved on 7 May 1982.[L6574] …

Nitrogen

Nitrogen is a chemical element with symbol N and atomic number 7. At room temperature, it is a transparent, odorless diatomic gas. Liquid nitrogen is used principally in cryotherapy for removal of diseased skin. Liquid nitrogen helps in removal of skin lesions through necrosis, which results from the freezing and...
Approved
Vet approved
Matched Description: … Nitrogen is a chemical element with symbol N and atomic number 7. …

Geraniol

Geraniol is a monoterpene that is found within many essential oils of fruits, vegetables, and herbs including rose oil, citronella, lemongrass, lavender, and other aromatic plants. It is emitted from the flowers of many species of plant and is commonly used by the food, fragrance, and cosmetic industry . Geraniol...
Approved
Experimental

Vitamin E

In 1922, vitamin E was demonstrated to be an essential nutrient . Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active . Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage . The antioxidant effects...
Approved
Nutraceutical
Vet approved
Matched Synonyms: … (2R,4'R,8'R)-α-tocopherol …
Matched Mixtures name: … Formula-4 Sx ... KORDEL`S NUTRITIME TABLET ... Aces Formula/formule A A S …

Sorafenib

Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also...
Approved
Investigational
Matched Synonyms: … N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea ... 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide …
Matched Iupac: … 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide …

Toripalimab

The proliferation of some cancers can be attributed, at least in part, to the suppression of host tumor surveillance. One mechanism by which this occurs is through the overexpression of programmed cell death ligand (PD-L1) - the binding of PD-L1 (and PD-L2) to its target receptor (PD-1) results in the...
Approved
Investigational

Streptococcus pneumoniae type 7f capsular polysaccharide antigen

Streptococcus pneumoniae type 7f capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 7f of Streptococcus pneumoniae. It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia.
Approved
Investigational

Eplontersen

Eplontersen is a transthyretin-directed antisense oligonucleotide with 3 covalently linked e N-acetyl galactosamine residues for hepatic delivery. It was previously investigated as a potential treatment for hereditary transthyretin-mediated amyloidosis. Hereditary transthyretin-mediated amyloidosis is caused primarily by pathogenic variants of the TTR gene, leading to the formation and thus accumulation of...
Approved
Investigational
Matched Description: … Phase 3 NEURO-TTRansform study, where a consistent improvement in the Neuropathy Impairment Score +7 ... (mNIS+7) and the Norfolk Quality of Life Questionnaire-Diabetic Neuropathy (Norfolk QoL-DN) Score were …

Brexpiprazole

Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to aripiprazole, brexpiprazole has different binding affinities for dopamine and serotonin receptors. Compared...
Approved
Investigational
Matched Iupac: … 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}-1,2-dihydroquinolin-2-one …
Matched Products: … REXULTI (BREXPIPRAZOLE) TABLETS 4 MG …

Donepezil

In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some...
Approved
Matched Iupac: … 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one …
Matched Salts cas: … 884740-09-4 …
Matched Mixtures name: … DEMENT COMBİ 10 MG / 15 MG AĞIZDA DAĞILAN TABLET, 7 TABLET ... DEMENT COMBİ 10 MG / 5 MG AĞIZDA DAĞILAN TABLET, 7 TABLET ... DEMENT COMBİ 10 MG / 10 MG AĞIZDA DAĞILAN TABLET, 7 TABLET …

Hypromellose

Hypromellose, or hydroxypropyl methylcellulose (HPMC) , is a semisynthetic, inert, and viscoelastic polymer that forms a colloid solution when dissolved in water. It acts as a thickening agent, coating polymer, bioadhesive, solubility enhancer in solid dispersions, and binder in the process of granulation and in modified release formulations . It...
Approved
Matched Mixtures name: … Clear Eyes Complete 7 Symptom Relief ... Clear Eyes Complete 7 Sympton Relief …

Lidocaine

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local...
Approved
Vet approved
Matched Mixtures name: … Lidocaine 7% / Tetracaine 7% ... Lidocaine 23% / Tetracaine 7% ... Lidocaine 23% / Tetracaine 7% …
Matched Products: … TLC Plus Anesthetic S ... NeuroMed Topical Anesthetic 7 ... NeuroMed 7 Topical Pain Relief …

Prucalopride

Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC...
Approved
Matched Iupac: … 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide …
Matched Description: … developed by Shire Development LLC and approved for use in Europe in 2009,[A40250] in Canada on December 7, …
Matched Salts cas: … 179474-80-7 …
Matched Categories: … Serotonin-4 Receptor Agonist ... Serotonin 4 Receptor Agonists …

Bexarotene

Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.
Approved
Investigational
Matched Synonyms: … 4-[1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl]benzoic acid ... 4-[1-(5,6,7,8,-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphtalenyl)ethenyl]benzoic acid …
Matched Iupac: … 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid …

Flotufolastat F-18

Flotufolastat F-18 (18F-rhPSMA-7.3) is an 18F-labeled ligand that targets the prostate-specific membrane antigen (PSMA).[A259846,L46731] In patients with recurrent prostate cancer that require localized treatment, the use of 18F-labeled ligands for positron emission tomography (PET) offers accurate diagnostic imaging. Unlike 68Ga-labeled PSMA-targeting ligands, 18F-labeled compounds targeting this protein have a longer...
Approved
Investigational
Matched Iupac: … (2S)-2-({[(1S)-1-carboxy-3-{[(1R)-1-carboxy-4-(3-{[(5R)-5-carboxy-5-[(2R)-2-[(4S)-4-carboxy-4-[4,7,10 ... -tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]butanamido]-3-({4-[di-tert-butyl((18F)fluoro) …
Matched Description: … Flotufolastat F-18 is a diastereoisomer of 18F-rhPSMA-7, and compared to the other diastereoisomers …

Caspofungin

Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal...
Approved
Matched Synonyms: … -4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline ... (4R,5S)-5-((2-Aminoethyl)amino)-N(sup 2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans …
Matched Iupac: … ,21S,24S,25S)-3-[(1R)-3-amino-1-hydroxypropyl]-21-[(2-aminoethyl)amino]-6-[(1S,2S)-1,2-dihydroxy-2-(4- …

Rifabutin

A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.
Approved
Investigational
Matched Synonyms: … 4-N-isobutylspiropiperidylrifamycin S ... 4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S ... 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin XIV …
Matched Categories: … Heterocyclic Compounds with 4 or More Rings …

Aztreonam

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Approved
Matched Synonyms: … (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino ... 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl) -2- {[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino} -2- oxoethylidene …
Matched Iupac: … -4-oxoazetidine-1-sulfonate ... (2S,3S)-3-[(2Z)-2-(2-azaniumyl-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-methyl …
Matched Salts cas: … 827611-49-4 …

Succinylcholine

Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter acetylcholine (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its...
Approved
Matched Iupac: … trimethyl[2-({4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl}oxy)ethyl]azanium …

Ethinamate

Ethinamate is a short-acting sedative-hypnotic medication used to treat insomnia. Like many such similar medications, the regular use of ethinamate can result in the development of drug tolerance in a patient. Nevertheless, the medication itself is generally no longer effective after using it for greater than 7 days. Structurally, it...
Approved
Illicit
Withdrawn
Matched Description: … Nevertheless, the medication itself is generally no longer effective after using it for greater than 7 …
Displaying drugs 126 - 150 of 8922 in total