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Identification
NameVitamin E
Accession NumberDB00163  (EXPT03227, NUTR00061)
TypeSmall Molecule
GroupsApproved, Nutraceutical
Description

A generic descriptor for all tocopherols and tocotrienols that exhibit alpha-tocopherol activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of isoprenoids. [PubChem]

Structure
Thumb
Synonyms
(+)-alpha-tocopherol
(+)-α-tocopherol
(2R,4'R,8'r)-alpha-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
(R,R,R)-alpha-tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
alpha-Tocopherol
d-alpha-tocopherol
d-α-tocopherol
Vitamin e
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Healing Ointment With Vitamin Eointment34 unitNutristar Health Products (1987) Inc.1983-12-311998-06-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Natural Source Vitamin E 1000 Iucapsule1000 unitoralLeiner Health Products Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vision E - 134iu/capcapsule134 unitoralNew Vision Nutritionals CompanyNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E (water Dispersible)capsule400 unitoralNusano Enterprises Ltd.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 1000 Iu - Water Solublecapsule1000 unitoralLeiner Health Products Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 200 Iu Capsulescapsule200 unitoralAshbury Research CorporationNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 30unit Ont Naturalointment30 unitEverest Pharmaceuticals Ltd.1982-12-311999-07-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400 Iu Capsulescapsule400 unitoralAshbury Research CorporationNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400 Iu Water Dispersible Supplementcapsule400 unitoralGarden State NutritionalsNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200unitcapsule200 unitEverest Pharmaceuticals Ltd.1980-12-311999-07-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200unit Natural Sourcecapsule200 unitRandle Labs Inc.1987-12-311997-05-30Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400iucapsule400 unitBionatal Drug Co1977-12-311999-07-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unitcapsule400 unitEverest Pharmaceuticals Ltd.1980-12-311999-07-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unitcapsule400 unitRandle Labs Inc.1987-12-311997-05-30Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unit Natural Sourcecapsule400 unitRandle Labs Inc.1987-12-311997-05-30Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 50unittablet50 unitoralStandard Process Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 800unitcapsule800 unitRandle Labs Inc.1987-12-311997-05-30Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Inj 100unit/mlliquid100 unitintramuscularKripps Pharmacy Ltd.1986-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Ontointment30 unitEverest Pharmaceuticals Ltd.1981-12-311999-07-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 400 U.I.capsule400 unitoralLaboratoire Riva IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription ProductsNot Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acti-copherols 200 Capcapsule200 unitoralActi Form Ltd.1991-12-312005-03-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Acti-D Alphacopherol Cap 400unitcapsule400 unitoralActi Form Ltd.1991-12-312005-03-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Acti-D Alphacopherol Cap 800unitcapsule800 unitoralActi Form Ltd.1991-12-312005-03-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Acti-succinate Caplet 400unittablet400 unitoralActi Form Ltd.1991-12-312005-03-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Advanced E With Non-medicinal Grape Seed Extractcapsule400 unitoralVita Health Products Inc2000-03-012002-07-30Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Chewable Vitamin E 200 I.U.tablet200 unitoralGeneral Nutrition Canada Inc.2000-01-282005-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Chewable Vitamin E 400 I.U.tablet400 unitoralGeneral Nutrition Canada Inc.2000-01-282005-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dl E 400 Cap 400unitcapsule400 unitoralThorne Research Canada Ltd.1984-12-311997-07-16Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
E 100 Cap Natural 100unitcapsule100 unitoralVita Health Products Inc1979-12-312008-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
E 100 Iucapsule100 unitoralNatural Factors Nutritional Products Ltd.2000-04-052008-07-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
E 100 Iu Capsulescapsule100 unitoralGahler Enterprises Ltd.1988-12-312000-04-20Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
E 200 Cap Natural 200unitcapsule200 unitoralVita Health Products Inc1979-12-312008-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
E 400 Iucapsule400 unitoralRegime Industries Ltd.2002-08-282007-07-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
E Vitamin 1000 I.U. (natural Source)capsule1000 unitoralH.J. Sutton Industries Ltd.1996-10-151998-08-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
E-400 Cap 400 Unitcapsule400 unitoralNu Life Nutrition Ltd.1987-12-312006-11-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
E-gems-Mcapsule800 unitoralJr Carlson Labs Inc1998-10-252005-09-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
E-prime Vitamin E Supplementcapsule200 unitoralUsana Health Sciences Inc.1999-09-302007-07-18Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Formula S.D.tablet100 unitoralChanges InternationalNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gnc Nat.srce.vit. E Caps. 100 Iu Mix Tocophrcapsule100 unitoralGeneral Nutrition Canada Inc.2001-10-012005-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Liquid Vitamin Eliquid200 unitoralGeneral Nutrition Canada Inc.2003-09-202007-08-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mycellized Vit E Liq 150unit/mlliquid150 unitoralMetagenics, Inc.1985-12-312005-08-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Natural Source Vitamin Ecapsule400 unitoralQuantofill Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Natural Source Vitamin E 400 Iucapsule400 unitoralViva Pharmaceutical Inc.2001-02-262009-12-22Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Natural Source Vitamin E 800 Iucapsule800 unitoralGeneral Nutrition Canada Inc.2002-06-012007-08-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Now E-400capsule400 unitoralNow Foods2005-03-312008-07-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nutrol E 200 Capcapsule7 unitoralRolmex International Inc.1974-12-312008-07-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Olympian Vit E Cap 400unitcapsule400 unitoralWeider Health Products1981-12-311999-09-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
One A Day With Non-medicinal Garlictablet100 unitoralBayer Inc Consumer Care2000-09-272002-08-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Organex E 100capsule100 unitoralSantÉ Naturelle (Ag) LtÉe1970-12-311997-09-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Organex E 400capsule400 unitoralSantÉ Naturelle (Ag) LtÉe1976-12-311997-09-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Organex E 800capsule800 unitoralSantÉ Naturelle (Ag) LtÉe1984-12-312002-06-18Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Phytomin E Cap 200unitcapsule200 unitoralProduits Phyto Inc.1973-12-312008-07-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Phytomin E Cap 800unitcapsule800 unitoralProduits Phyto Inc.1979-12-312008-07-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Pro E Cap 200unitcapsule200 unitoralProfessional Health Products1987-12-311997-08-22Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Super Gardialine Cap 100iucapsule100 unitoralLes Laboratoires Vachon Inc.1971-12-312008-02-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Synthetic Vitamin Ecapsule400 unitoralQuantofill Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vit E Cap 800unitcapsule800 mgoralWampole Brands1981-12-312009-06-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vita-Ecapsule200 unitoralFrega Inc.1985-12-312008-07-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vita-E 25 Capsulescapsule25 unitoralShaklee Canada Inc1978-12-312000-07-20Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin Ecapsule400 unitoralEnrich International1998-06-112009-08-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 100 Iu Dietary Supplementcapsule100 unitoralGarden State Nutritionals1998-09-222000-06-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 100 Iu Natural Sourcecapsule100 unitoralWn Pharmaceuticals Ltd.2002-03-132005-08-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 1000 I.U. (natural Source)capsule1000 unitoralVita Health Products Inc1999-11-292002-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 1000 Iucapsule1000 unitoralWn Pharmaceuticals Ltd.1999-12-222005-08-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 1000 Iu Dietary Supplementcapsule1000 unitoralGarden State Nutritionals1998-09-222000-06-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 1000iucapsule1000 unitoralWn Pharmaceuticals Ltd.2000-11-302006-08-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 200 I.U. (natural Source)capsule200 unitoralVita Health Products Inc1998-05-202008-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 200iu Chewabletablet200 unitoralVita Health Products Inc1999-09-302005-07-20Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 200iu Thuna'scapsule200 unitoralThuna Herbal Remedies Ltd.1980-06-112002-10-16Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 25 Iu Thuna'scapsule25 unitoralThuna Herbal Remedies Ltd.1980-06-112002-10-16Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400 I.U.capsule400 mgoralViva Pharmaceutical Inc.1997-01-062009-12-22Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400 I.U. (natural Source)capsule400 unitoralVita Health Products Inc1998-05-202008-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400 Iucapsule400 unitoralPreferred Nutrition Inc.2004-05-262007-08-03Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400 Iucapsule400 unitoralAmco Pharmaceuticals Inc.1999-09-242003-12-03Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400 Iu - Capsulecapsule400 unitoralSwiss Herbal Remedies Ltd.1996-09-102009-08-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400 Iu USPcapsule400 unitoralNutravite Pharmaceuticals Inc.2003-02-242007-07-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400 Iu Water Solublecapsule400 unitoralVita Health Products Inc1997-04-022008-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400iucapsule400 unitoralNatural Factors Nutritional Products Ltd.2004-04-212007-08-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400unit Capcapsule400 unitoralSwiss Herbal Remedies Ltd.1988-12-312007-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 400unit Croquablestablet400 unitoralLaboratoire Lalco Inc.1988-12-312004-07-26Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 800 I.U.capsule800 unitoralWn Pharmaceuticals Ltd.1998-08-242008-07-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 800 Iu Natural Sourcecapsule800 unitoralPharmavite Llc1996-10-242006-07-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E 800 Iu Syntheticcapsule800 unitoralWn Pharmaceuticals Ltd.2002-05-312005-08-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Acetate Cap 800tcapsule800 unitoralGahler Enterprises Ltd.1990-12-312008-07-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 1000iucapsule1000 unitoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1970-12-312002-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 1000unitcapsule1000 unitoralIcn Canada Ltd.1979-12-312005-04-26Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 1000unitcapsule1000 unitoralNutri Dyn Products Ltd.1978-12-311997-08-22Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 1000unitcapsule1000 unitoralSantÉ Naturelle (Ag) LtÉe1984-12-312002-06-18Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 1000unitcapsule1000 unitoralNobel Pharm Enr.1981-12-311997-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 1000unit USPcapsule1000 unitoralPharmavite Llc1987-12-312006-07-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 1000unit USP Natural Sourcecapsule1000 unitoralPharmavite Llc1987-12-312006-07-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 100unitcapsule100 unitoralLaboratoire Lalco Inc.1963-12-311997-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 100unitcapsule100 unitoralNobel Pharm Enr.1983-12-311997-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 100unitcapsule100 unitoralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 100unitcapsule100 unitoralAlbi Naturals1979-12-312008-07-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 100unitcapsule100 unitoralHilcoa, Division Of Jeunique International1973-12-311996-10-22Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 100unitcapsule100 unitoralNature's Sunshine Products Of Canada Ltd.1979-12-312001-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 100unit USP Natural Sourcecapsule100 unitoralPharmavite Llc1987-12-311997-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200iucapsule200 unitoralTrophic Canada Ltd.1969-12-312008-08-28Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200iu Nf Natural Sourcecapsule200 unitoralWampole Brands1973-12-312009-06-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200unitcapsule200 unitoralShoppers Drug Mart Inc.1979-12-311997-08-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200unitcapsule200 unitoralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200unitcapsule200 unitoralNobel Pharm Enr.1981-12-312001-10-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200unitcapsule200 unitoralLaboratoire Lalco Inc.1972-12-311997-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200unitcapsule200 unitoralAlbi Naturals1979-12-312008-07-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200unit USPcapsule200 unitoralPharmavite Llc1987-12-312005-07-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200unit USP Natural Sourcecapsule200 unitoralPharmavite Llc1987-12-312005-07-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 200unit Watkinscapsule200 unitoralWatkins Incorporated1975-12-312000-01-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400 Unitcapsule400 unitoralNature's Sunshine Products Of Canada Ltd.1981-12-312009-08-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400iucapsule400 unitoralSwiss Herbal Remedies Ltd.1972-12-312004-09-03Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unitcapsule400 unitoralNobel Pharm Enr.1981-12-312001-10-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unitcapsule400 unitoralAlbi Naturals1979-12-312009-07-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unitcapsule400 unitoralVitalab1990-12-312005-07-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unitcapsule400 unitoralCountry Health Laboratories Ltd.1981-12-312001-07-27Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unitcapsule400 unitoralNobel Pharm Enr.1983-12-312001-10-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unitcapsule400 unitoralShoppers Drug Mart Inc.1979-12-311997-08-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unitcapsule400 unitoralRheingold Food International Ltd.1985-12-312007-07-26Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unit USPcapsule400 unitoralPharmavite Llc1987-12-312006-07-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unit USP Nat Sourcecapsule400 unitoralPharmavite Llc1987-12-312006-07-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 400unit USP Water Solubilizedcapsule400 unitoralPharmavite Llc1987-12-312006-07-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 800 Unit Naturalcapsule800 unitoralVita Health Products Inc1974-12-312008-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 800iunf Naturalcapsule800 unitoralWampole Brands1975-12-312009-06-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 800unitcapsule800 unitoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1981-12-312002-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 800unitcapsule800 unitoralAlbi Naturals1979-12-312008-07-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 800unitcapsule800 unitoralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 800unitcapsule800 unitoralVita Health Products Inc1983-12-312008-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 800unitcapsule800 unitoralShoppers Drug Mart Inc.1982-12-311998-08-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap 800unit USPcapsule800 unitoralNu Life Nutrition Ltd.1987-12-312005-03-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap USP 1000unitcapsule1000 unitoralQuest Vitamins A Div Of Purity Life Health Products1980-12-312006-07-25Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap USP 1000unit Water Solubilizedcapsule1000 unitoralPharmavite Llc1987-12-312006-07-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap USP 100iucapsule100 unitoralPharmetics (2011) Inc1981-12-312001-07-26Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap USP 200iucapsule200 unitoralPharmetics (2011) Inc1981-12-312006-07-27Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Cap USP Nat Ratio 200unitcapsule200 unitoralQuest Vitamins A Div Of Purity Life Health Products1984-12-312006-07-25Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Caps USP 200unitcapsule200 unitoralLab Gernetic Int Ltee1986-12-311997-02-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Capsules 400iucapsule400 unitoralD.C. Labs Limited1973-12-312005-07-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Capsules 400unitcapsule400 unitoralD.C. Labs Limited1982-12-312005-07-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Capsules 800iucapsule800 unitoralD.C. Labs Limited1977-12-312005-07-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Capsules USP 400 I.U.capsule400 unitoralNpr Laboratories Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Chewable Tab 400unittablet400 unitoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1991-12-311998-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Dietary Supplementtablet400 unitoralGarden State Nutritionals1998-08-312000-06-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Ointment 50unit/gmointment50 unittopicalVita Health Products Inc1991-12-312005-07-20Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Ont 1000unitointment1000 unittopicalAlbi Naturals1982-12-312008-07-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Ont 30unit/gmointment30 unittopicalSwiss Herbal Remedies Ltd.1984-12-312007-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Pure 800 I.U.capsule800 unitoralWn Pharmaceuticals Ltd.1998-06-262007-08-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Tab 200unit Chewabletablet200 unitoralShaklee Canada Inc1981-12-312000-07-20Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamin E Tab 400unittablet (enteric-coated)400 unitoralKlaire Labs Inc.1983-12-311999-01-18Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 100 I.U.capsule100 unitoralLe Naturiste J.M.B. Inc.1997-09-012000-08-23Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 100 Uicapsule100 unitoralGamme Nature2002-06-302008-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 100capcapsule100 unitoralLe Naturiste J.M.B. Inc.1977-12-311998-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 100ui Capsulecapsule100 unitoralBio Vita1988-03-231997-08-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 200 Capcapsule200 unitoralLe Naturiste J.M.B. Inc.1979-12-312001-08-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 200 U.I.capsule200 unitoralGamme Nature1997-09-092008-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 400 U.I.capsule400 unitoralGamme Nature1997-08-202008-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 400iu Capcapsule400 unitoralLaboratoire Lalco Inc.1979-12-312008-07-29Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 800 I.U.capsule800 unitoralGamme Nature1997-08-202008-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E 800 Ui Naturelle -capcapsule800 unitoralNobel Pharm Enr.1995-12-312001-10-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Cap 100iucapsule100 unitoralLes Produits Gerbex Inc.1972-12-312007-12-28Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Cap 100unitcapsule100 unitoralVitalab1990-12-311997-07-22Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Cap 200unitcapsule200 unitoralPharmalab Inc.1990-12-311997-08-08Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Cap 200unitcapsule200 unitoralVitalab1990-12-312005-07-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Cap 200unitcapsule200 unitoralNobel Pharm Enr.1981-12-311997-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Cap 400unitcapsule400 unitoralLe Naturiste J.M.B. Inc.1980-12-312001-08-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Cap 400unitcapsule400 unitoralSuperco Enr.1974-12-311999-07-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Cap USP 800unitcapsule800 unitoralLe Naturiste J.M.B. Inc.1987-12-311997-07-23Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Caps 800unit USPcapsule800 unitoralLes Produits Gerbex Inc.1989-12-311997-08-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Capsules 25uicapsule25 unitoralHerbes Universelles Inc.1967-12-312009-07-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E Creme 250unit/mlcream250 unittopicalLaboratoire Lalco Inc.1987-12-312007-08-16Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vitamine E25vi Capsulecapsule25 unitoralBio Vita1988-03-231997-08-07Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vl Micel E Liq 100unit/mlliquid100 unitoralKlaire Labs Inc.1984-12-312004-12-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Webber Vitamin E Cap 400unit Natural Sourcecapsule400 unitoralCiba Self Medication1992-12-311997-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Webber Vitamin E Cap 400unit Originalcapsule400 unitoralCiba Self Medication1992-12-311997-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Webber Vitamin E Cap 800unit Originalcapsule800 unitoralCiba Self Medication1992-12-311997-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Webber Vitamin E Liq 77unit/ml Water Solliquid77 unitoralCiba Self Medication1992-12-311997-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Webber Vitamin E Succ Cap 400unit(dri Caps)capsule400 unitoralCiba Self Medication1992-12-311997-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
International Brands
NameCompany
Amino-Opti-ENot Available
Aquasol ENot Available
Brand mixtures
NameLabellerIngredients
Acti-A D E LiqActi Form Ltd.
Advanced E With Vitamin C & Non-medicinal Alpha Lipoic AcidVita Health Products Inc
Avon Nutrivance Stress FormulaAvon Canada Ulc
B Stress C + Iron & ViteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Balanced B-complex Vit + Vit C&e TabPharmavite Llc
Bear EssentialsHealth Asure, Inc.
C.R.D.-forcePrairie Naturals
Carbassist TabletsWyeth Consumer Healthcare Inc.
Cedevita Plus Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cedevita Sugar-free Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Chewable Children's Complete Multivitamins With Essential MineralsWn Pharmaceuticals Ltd.
Children Choice Multivit Chewable TabSwiss Herbal Remedies Ltd.
Children's Chewable Multi-vitamin Complete With MineralsWn Pharmaceuticals Ltd.
Children's Chewable Multivitamins With MineralsWn Pharmaceuticals Ltd.
Childrens Chewable Multiple Vitamins TabPharmavite Llc
Citranatal DHAMission Pharmacal Company
Citranatal Harmony 3.0Mission Pharmacal Company
Citranatal RxMission Pharmacal Company
Dio WhiteningDio Corporation
Dr. Waltons Baby PowderDr. Waltons, Incorporated
EnzogenolSisu Inc.
Family Care Thera FlexUNITED EXCHANGE CORP.
Feminique W Iron and Calcium TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Folcaps Care OneMidlothian Laboratories
Folcaps Omega-3Midlothian Laboratories
Folic Acid PlusVita Health Products Inc
Formula Ma-vitamin E & Zinc TabMetagenics, Inc.
Formula Sf-710Thorne Research Inc.
Formula-4 SxAbundance Marketing Ltd.
Hemenatal ObWh Nutritionals, Llc
Homosistrol CapsulesMacromed Pharmicia Inc.
Homosistrox CapsulesS.A.F. Nutritional Products Inc.
Inner Health Vitamin Supplement CapsulesUsana Health Sciences Inc.
Iron ComplexPremier Plus Supplements Inc.
Kanga-kid Multi-vitamin & MineralLacombe Drugs (1992) Ltd
Kimchi Vitamin Chewable MultivitaminTobico
Leritone AntistressInstitut De Recherche Biologique Yves Ponroy Canada Inc.
Leritone JuniorInstitut De Recherche Biologique Yves Ponroy Canada Inc.
Leritone Magnesium & Vitamine EInstitut De Recherche Biologique Yves Ponroy Canada Inc.
Mnps Formula SupplementGarden State Nutritionals
Multi #2W 7 Clay Inc.
Multi Vitamin & MineralsWn Pharmaceuticals Ltd.
Multi Vitamin and FluorideLibertas Pharma, Inc.
Multi Vitamin Drops With FluorideSeton Pharmaceuticals
Multi Vitamin Drops With Fluoride and IronSeton Pharmaceuticals
Multi Vitamin Drops With Fluoride With IronStratus Pharmaceuticals
Multi Vitamin Plus IronWn Pharmaceuticals Ltd.
Multi Vitamin, Iron and FluorideLibertas Pharma, Inc.
Multi-vitaminLLC Federal Solutions
Multi-vitamin FluorideStratus Pharmaceuticals
Multi-vitamin Fluoride and Iron DropsBoca Pharmacal, LLC
Multi-vitamin Fluoride DropsH.J. Harkins Company, Inc.
Multi-vitamin With FluorideGolden State Medical Supply, Inc.
Multi-vitaminsWn Pharmaceuticals Ltd.
Multi-vitamins for Infusion LiqDavid Bull Laboratories (Pty) Ltd.
Multivitamin and MineralJamieson Laboratories Ltd
MvcSancilio & Company Inc
Mvc-fluorideSancilio & Company Inc.
Nata KompleteWh Nutritionals, Llc
Natelle OneMEDA Pharmaceuticals
Nexa PlusUpsher Smith Laboratories, Inc.
Nexa Select Rx Prenatal Vitamin With Plant-based DHAUpsher Smith Laboratories, Inc.
Ni-C-E-LE PlusNutrimetics International (Canada) Inc.
Niron KompleteWh Nutritionals, Llc
O-cal Prenatal VitaminPharmics, Inc.
OcuvelAdler Stern Pharmaceuticals, Llc
Ocuvite Vitamin and Mineral Supplement CapsulesBausch & Lomb Inc
P-plusThorne Research Inc.
Pml CronoSifi North America Inc./ Sifi Amerique Du Nord Inc.
Polymine Avec Zinc Et CuivreLes Laboratoires Vachon Inc.
Prefera Ob Plus DHAAlaven Pharmaceutical LLC
PreferaobMEDA Pharmaceuticals
Preferaob Plus DHAAlaven Pharmaceutical LLC
Prenatal Mega AntioxidantUsana Health Services, Inc.
Prenatal Vitamins Plusbryant ranch prepack
Reaphirm Plant Source DHAEverett Laboratories, Inc.
Reliv So Sense Daily Vitamin SupplementReliv International Inc.
Richennapharm Growmax Hair Care TonicSEWHA P&C INC
RogenicEnzymatic Therapy (Canada) Inc.
Simmyungsaengmosu Hair TonicSimmyung Pharmaceutical Co Ltd
Soin Solaire Complete Spf30Elemis Limited
Stress B Complex With C, E & IronPharmavite Llc
Stress Complex 600 Avec Vit E Cuivre ZincFrega Inc.
Stress FormulaVita Health Products Inc
Stress Formula + IronVita Health Products Inc
Stress Formula Multivitamin Tablets USPLeiner Health Products Inc.
Stress Tab With Iron and Vitamin EVita Health Products Inc
Stress Tab With Zinc, Copper and Vitamin EVita Health Products Inc
Stressease Plus Vitamins and MineralsJamieson Laboratories Ltd
Strovite Forte CapletEverett Laboratories, Inc.
Strovite One CapletsEverett Laboratories, Inc.
Supravite Stress Avec Vit EPharmalab Inc.
Supravite Stress Avec Vit E Cuivre Et ZincPharmalab Inc.
Supravite Stress Avec Vit E Et FerPharmalab Inc.
SveetsSensible Delights Specialty Foods
Tianshi Calcium With Natural Source Vitamin E Softgel CapsulesTianjin Tianshi Group Co., Ltd.
TozalFocus Laboratories, Inc.
Vigo Multivitamins Drops/lozengeAshbury Research Corporation
Virt-PNVirtus Pharmaceuticals
Virt-PN PlusVirtus Pharmaceuticals LLC
Vitafol CapletEverett Laboratories, Inc.
Vitafol Ob CapletEverett Laboratories, Inc.
Vitafol OneEverett Laboratories, Inc.
Vitafol PlusEverett Laboratories, Inc.
VitalisImport Export SantÉ Nature Inc.
Vitamin and Mineral Supplement CapsulesVita Health Products Inc
Vitamin D3dietary Supplemen Dietary SupplementNnodum Pharmaceuticals
VitamuneNu Skin Canada, Inc.
Vitogen B Stress C Vit E Zinc & CopStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vp-heme ObVirtus Pharmaceuticals LLC
Vp-heme OneVirtus Pharmaceuticals LLC
Z-force Vitamin and Mineral SupplementDymatize Enterprises Inc.
Salts
Name/CASStructureProperties
Alpha-tocopherol acetate
ThumbNot applicableDBSALT001457
Alpha-tocopherol succinate, d-
ThumbNot applicableDBSALT001494
Tocopherol acetate
ThumbNot applicableDBSALT001399
Categories
CAS number59-02-9
WeightAverage: 430.7061
Monoisotopic: 430.381080844
Chemical FormulaC29H50O2
InChI KeyInChIKey=GVJHHUAWPYXKBD-IEOSBIPESA-N
InChI
InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
IUPAC Name
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol
SMILES
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCC2=C(O1)C(C)=C(C)C(O)=C2C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tocopherols. These are vitamin E derivatives containing a saturated trimethyltridecyl chain attached to the carbon C6 atom of a benzopyran ring system. The differ from tocotrienols that contain an unsaturated trimethyltrideca-3,7,11-trien-1-yl chain.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassPrenol lipids
Sub ClassQuinone and hydroquinone lipids
Direct ParentTocopherols
Alternative Parents
Substituents
  • Tocopherol
  • Diterpenoid
  • 1-benzopyran
  • Benzopyran
  • Chromane
  • Alkyl aryl ether
  • Benzenoid
  • Oxacycle
  • Organoheterocyclic compound
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationVitamin E, known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. It may be of limited benefit in some with asthma and rheumatoid arthritis. It may be helpful in some neurological diseases including Alzheimer's, some eye disorders including cataracts, and diabetes and premenstrual syndrome. It may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported. It may help relieve some muscle cramps.
PharmacodynamicsVitamin E has antioxidant activity. It may also have anti-atherogenic, antithrombotic, anticoagulant, neuroprotective, antiviral, immunomodulatory, cell membrane-stabilizing and antiproliferative actions. Vitamin E is a collective term used to describe eight separate forms, the best-known form being alpha-tocopherol. Vitamin E is a fat-soluble vitamin and is an important antioxidant. It acts to protect cells against the effects of free radicals, which are potentially damaging by-products of the body's metabolism. Vitamin E is often used in skin creams and lotions because it is believed to play a role in encouraging skin healing and reducing scarring after injuries such as burns. There are three specific situations when a vitamin E deficiency is likely to occur. It is seen in persons who cannot absorb dietary fat, has been found in premature, very low birth weight infants (birth weights less than 1500 grams, or 3½ pounds), and is seen in individuals with rare disorders of fat metabolism. A vitamin E deficiency is usually characterized by neurological problems due to poor nerve conduction. Symptoms may include infertility, neuromuscular impairment, menstrual problems, miscarriage and uterine degradation. Preliminary research has led to a widely held belief that vitamin E may help prevent or delay coronary heart disease. Antioxidants such as vitamin E help protect against the damaging effects of free radicals, which may contribute to the development of chronic diseases such as cancer. It also protects other fat-soluble vitamins (A and B group vitamins) from destruction by oxygen. Low levels of vitamin E have been linked to increased incidence of breast and colon cancer.
Mechanism of actionAlthough all forms of Vitamin E exhibit antioxidant activity, it is known that the antioxidant activity of vitamin E is not sufficient to explain the vitamin's biological activity.
Vitamin E's anti-atherogenic activity involves the inhibition of the oxidation of LDL and the accumulation of oxLDL in the arterial wall. It also appears to reduce oxLDL-induced apoptosis in human endothelial cells. Oxidation of LDL is a key early step in atherogenesis as it triggers a number of events which lead to the formation of atherosclerotic plaque. In addition, vitamin E inhibits protein kinase C (PKC) activity. PKC plays a role in smooth muscle cell proliferation, and, thus, the inhibition of PKC results in inhibition of smooth muscle cell proliferation, which is involved in atherogenesis.
Vitamin E's antithrombotic and anticoagulant activities involves the downregulation of the expression of intracellular cell adhesion molecule(ICAM)-1 and vascular cell adhesion molecule(VCAM)-1 which lowers the adhesion of blood components to the endothelium. In addition, vitamin E upregulates the expression of cytosolic phospholipase A2 and cyclooxygenase (COX)-1 which in turn enhances the release of prostacyclin. Prostacyclin is a vasodilating factor and inhibitor of platelet aggregation and platelet release. It is also known that platelet aggregation is mediated by a mechanism involving the binding of fibrinogen to the glycoprotein IIb/IIIa (GPIIb/IIIa) complex of platelets. GPIIb/IIIa is the major membrane receptor protein that is key to the role of the platelet aggregation response. GPIIb is the alpha-subunit of this platelet membrane protein. Alpha-tocopherol downregulates GPIIb promoter activity which results in reduction of GPIIb protein expression and decreased platelet aggregation. Vitamin E has also been found in culture to decrease plasma production of thrombin, a protein which binds to platelets and induces aggregation. A metabolite of vitamin E called vitamin E quinone or alpha-tocopheryl quinone (TQ) is a potent anticoagulant. This metabolite inhibits vitamin K-dependent carboxylase, which is a major enzyme in the coagulation cascade.
The neuroprotective effects of vitamin E are explained by its antioxidant effects. Many disorders of the nervous system are caused by oxidative stress. Vitamin E protects against this stress, thereby protecting the nervouse system.
The immunomodulatory effects of Vitamin E have been demonstrated in vitro, where alpha-tocopherol increases mitogenic response of T lymphocytes from aged mice. The mechanism of this response by vitamin E is not well understood, however it has been suggested that vitamin E itself may have mitogenic activity independent of its antioxidant activity.
Lastly, the mechanism of action of vitamin E's antiviral effects (primarily against HIV-1) involves its antioxidant activity. Vitamin E reduces oxidative stress, which is thought to contribute to HIV-1 pathogenesis, as well as to the pathogenesis of other viral infections. Vitamin E also affects membrane integrity and fluidity and, since HIV-1 is a membraned virus, altering membrane fluidity of HIV-1 may interfere with its ability to bind to cell-receptor sites, thus decreasing its infectivity.
Absorption50 to 80% absorbed from gastrointestinal tract.
Volume of distributionNot Available
Protein bindingBound to beta-lipoproteins in blood.
Metabolism

Hepatic.

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9795
Blood Brain Barrier+0.9767
Caco-2 permeable+0.8484
P-glycoprotein substrateSubstrate0.7189
P-glycoprotein inhibitor INon-inhibitor0.7598
P-glycoprotein inhibitor IIInhibitor0.7802
Renal organic cation transporterNon-inhibitor0.7882
CYP450 2C9 substrateNon-substrate0.6949
CYP450 2D6 substrateNon-substrate0.7813
CYP450 3A4 substrateSubstrate0.7533
CYP450 1A2 substrateNon-inhibitor0.8122
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7762
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8813
BiodegradationNot ready biodegradable0.9965
Rat acute toxicity2.1598 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7192
hERG inhibition (predictor II)Non-inhibitor0.6449
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Capsuleoral400 unit
Powderoral
Tabletoral
Paste, dentifricedental
Powdertopical
Patchtopical
Ointment34 unit
Tablet (effervescent)oral
Liquidoral200 unit
Solution/ dropsoral
Liquidoral
Solutionoral
Liquidintravenous
Tablet, chewableoral
Liquidoral150 unit
Capsule, gelatin coatedoral
Capsuleoral
Capsuleoral7 unit
Tabletoral100 unit
Tablet, coatedoral
Powder for solutionoral
Liquidtopical
Emulsiontopical
Lozengeoral
Capsuleoral134 unit
Capsuleoral800 mg
Capsule, liquid filledoral
Capsuleoral400 mg
Capsuleoral1000 unit
Capsule200 unit
Capsule400 unit
Tabletoral50 unit
Capsule800 unit
Tabletoral400 unit
Liquidintramuscular100 unit
Ointmenttopical50 unit
Ointment30 unit
Ointmenttopical1000 unit
Ointmenttopical30 unit
Tabletoral200 unit
Tablet (enteric-coated)oral400 unit
Capsuleoral100 unit
Capsuleoral200 unit
Capsuleoral800 unit
Creamtopical250 unit
Capsuleoral25 unit
Liquidoral100 unit
Tablet, film coatedoral
Liquidoral77 unit
Prices
Unit descriptionCostUnit
Vitamin e acetate liquid1.07USD ml
Ester-e 400 unit softgel0.26USD softgel capsule
Vit e nat'l blnd 1000 unit capsule0.2USD capsule
Vitamin e 400 unit tablet0.19USD tablet
E pherol 400 unit tablet0.13USD tablet
Vitamin e 1000 unit capsule0.13USD capsule
Vitamin e beauty oil0.1USD ml
CVS Pharmacy vitamin e 800 unit softgel0.09USD softgel capsule
Vitamin e 600 unit capsule0.07USD capsule
Vitamin e 400 unit capsule0.06USD capsule
CVS Pharmacy vitamin e 400 unit capsule0.05USD capsule
Vitamin e 200 unit capsule0.05USD each
CVS Pharmacy vitamin e 200 unit softgel0.04USD softgel capsule
Natural vitamin e 400 unit cap0.04USD capsule
Natural vitamin e 400 unit capsule0.04USD capsule
Vitamin e 100 unit capsule0.04USD capsule
Vitamin e 400 unit softgel0.04USD softgel capsule
CVS Pharmacy vitamin e plus cream0.03USD g
Natural vit e 200 unit capsule0.03USD capsule
Vitamin e cream0.02USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point3 °CPhysProp
water solubilityInsoluble in water, but water-dispersible.Not Available
logP10Not Available
Predicted Properties
PropertyValueSource
Water Solubility7.04e-06 mg/mLALOGPS
logP8.84ALOGPS
logP10.51ChemAxon
logS-7.8ALOGPS
pKa (Strongest Acidic)10.8ChemAxon
pKa (Strongest Basic)-4.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.46 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity135.37 m3·mol-1ChemAxon
Polarizability55.29 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-4cz0000000-fc8c4f9b9405598ede7fView in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-z7l0050000-c4abc0e689e9b2476b9dView in MoNA
GC-MSGC-MS Spectrum - GC-MS (1 TMS)splash10-55z00h0000-663296a69129a59be1a6View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-zo00600000-aaf885290800a10d3fb2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-zc00000000-f0c814976a58a9d837caView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-7izht00000-6b5f8f817c5a5429ed70View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-EBEB (JMS-HX/HX 110A, JEOL) , Positivesplash10-iz40o00000-1eda05dacf9642d7cea0View in MoNA
MSMass Spectrum (Electron Ionization)splash10-bz20j00000-03e8a824731610752eb3View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Ralph E. Close, William Oroshnik, “Synthesis of dehydrophytol and Vitamin E.” U.S. Patent US4039591, issued February, 1945.

US4039591
General References
  1. Iuliano L, Micheletta F, Maranghi M, Frati G, Diczfalusy U, Violi F: Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products. Arterioscler Thromb Vasc Biol. 2001 Oct;21(10):E34-7. Pubmed
  2. Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E: Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005 Jan 4;142(1):37-46. Epub 2004 Nov 10. Pubmed
  3. Horwitt MK, Elliott WH, Kanjananggulpan P, Fitch CD: Serum concentrations of alpha-tocopherol after ingestion of various vitamin E preparations. Am J Clin Nutr. 1984 Aug;40(2):240-5. Pubmed
  4. Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS: Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med. 2006 Apr 27;354(17):1796-806. Pubmed
  5. Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH: Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet. 2006 Apr 8;367(9517):1145-54. Pubmed
  6. Linus Pauling Institute Link
External Links
ATC CodesNot Available
AHFS Codes
  • 84:24.12
  • 88:20.00
PDB Entries
FDA labelNot Available
MSDSDownload (74.1 KB)
Interactions
Drug Interactions
Drug
AbciximabVitamin E may increase the antiplatelet activities of Abciximab.
AcenocoumarolVitamin E may increase the anticoagulant activities of Acenocoumarol.
Acetylsalicylic acidVitamin E may increase the antiplatelet activities of Acetylsalicylic acid.
AnagrelideVitamin E may increase the antiplatelet activities of Anagrelide.
ApixabanVitamin E may increase the anticoagulant activities of Apixaban.
ArgatrobanVitamin E may increase the anticoagulant activities of Argatroban.
BivalirudinVitamin E may increase the anticoagulant activities of Bivalirudin.
CaffeineVitamin E may increase the antiplatelet activities of Caffeine.
CangrelorVitamin E may increase the antiplatelet activities of Cangrelor.
CilostazolVitamin E may increase the antiplatelet activities of Cilostazol.
CitalopramVitamin E may increase the antiplatelet activities of Citalopram.
Citric AcidVitamin E may increase the anticoagulant activities of Citric Acid.
ClopidogrelVitamin E may increase the antiplatelet activities of Clopidogrel.
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Vitamin E.
Dabigatran etexilateVitamin E may increase the anticoagulant activities of Dabigatran etexilate.
DalteparinVitamin E may increase the anticoagulant activities of Dalteparin.
DanaparoidVitamin E may increase the anticoagulant activities of Danaparoid.
DesirudinVitamin E may increase the anticoagulant activities of Desirudin.
DesvenlafaxineVitamin E may increase the antiplatelet activities of Desvenlafaxine.
DiclofenacVitamin E may increase the antiplatelet activities of Diclofenac.
DicoumarolVitamin E may increase the anticoagulant activities of Dicoumarol.
DiflunisalVitamin E may increase the antiplatelet activities of Diflunisal.
DihydrocodeineVitamin E may increase the antiplatelet activities of Dihydrocodeine.
DipyridamoleVitamin E may increase the antiplatelet activities of Dipyridamole.
DuloxetineVitamin E may increase the antiplatelet activities of Duloxetine.
Edetic AcidVitamin E may increase the anticoagulant activities of Edetic Acid.
EdoxabanVitamin E may increase the anticoagulant activities of Edoxaban.
EnoxaparinVitamin E may increase the anticoagulant activities of Enoxaparin.
EptifibatideVitamin E may increase the antiplatelet activities of Eptifibatide.
EscitalopramVitamin E may increase the antiplatelet activities of Escitalopram.
Ethyl biscoumacetateVitamin E may increase the anticoagulant activities of Ethyl biscoumacetate.
EtodolacVitamin E may increase the antiplatelet activities of Etodolac.
FenoprofenVitamin E may increase the antiplatelet activities of Fenoprofen.
FloctafenineVitamin E may increase the antiplatelet activities of Floctafenine.
FluoxetineVitamin E may increase the antiplatelet activities of Fluoxetine.
FlurbiprofenVitamin E may increase the antiplatelet activities of Flurbiprofen.
FluvoxamineVitamin E may increase the antiplatelet activities of Fluvoxamine.
Fondaparinux sodiumVitamin E may increase the anticoagulant activities of Fondaparinux sodium.
HeparinVitamin E may increase the anticoagulant activities of Heparin.
IbrutinibVitamin E may increase the antiplatelet activities of Ibrutinib.
IbuprofenVitamin E may increase the antiplatelet activities of Ibuprofen.
IndomethacinVitamin E may increase the antiplatelet activities of Indomethacin.
KetoprofenVitamin E may increase the antiplatelet activities of Ketoprofen.
KetorolacVitamin E may increase the antiplatelet activities of Ketorolac.
LevomilnacipranVitamin E may increase the antiplatelet activities of Levomilnacipran.
Mefenamic acidVitamin E may increase the antiplatelet activities of Mefenamic acid.
MeloxicamVitamin E may increase the antiplatelet activities of Meloxicam.
MilnacipranVitamin E may increase the antiplatelet activities of Milnacipran.
NabumetoneVitamin E may increase the antiplatelet activities of Nabumetone.
NadroparinVitamin E may increase the anticoagulant activities of Nadroparin.
NaproxenVitamin E may increase the antiplatelet activities of Naproxen.
OrlistatThe serum concentration of Vitamin E can be decreased when it is combined with Orlistat.
OxaprozinVitamin E may increase the antiplatelet activities of Oxaprozin.
ParoxetineVitamin E may increase the antiplatelet activities of Paroxetine.
PhenindioneVitamin E may increase the anticoagulant activities of Phenindione.
PhenprocoumonVitamin E may increase the anticoagulant activities of Phenprocoumon.
PiroxicamVitamin E may increase the antiplatelet activities of Piroxicam.
PrasugrelVitamin E may increase the antiplatelet activities of Prasugrel.
RivaroxabanVitamin E may increase the anticoagulant activities of Rivaroxaban.
SertralineVitamin E may increase the antiplatelet activities of Sertraline.
SulindacVitamin E may increase the antiplatelet activities of Sulindac.
SulodexideVitamin E may increase the anticoagulant activities of Sulodexide.
Tiaprofenic acidVitamin E may increase the antiplatelet activities of Tiaprofenic acid.
TicagrelorVitamin E may increase the antiplatelet activities of Ticagrelor.
TiclopidineVitamin E may increase the antiplatelet activities of Ticlopidine.
TinzaparinVitamin E may increase the anticoagulant activities of Tinzaparin.
TipranavirThe risk or severity of adverse effects can be increased when Tipranavir is combined with Vitamin E.
TirofibanVitamin E may increase the antiplatelet activities of Tirofiban.
TolmetinVitamin E may increase the antiplatelet activities of Tolmetin.
TreprostinilVitamin E may increase the anticoagulant activities of Treprostinil.
VenlafaxineVitamin E may increase the antiplatelet activities of Venlafaxine.
VilazodoneVitamin E may increase the antiplatelet activities of Vilazodone.
VorapaxarVitamin E may increase the antiplatelet activities of Vorapaxar.
VortioxetineVitamin E may increase the antiplatelet activities of Vortioxetine.
WarfarinVitamin E may increase the anticoagulant activities of Warfarin.
Food InteractionsNot Available

Targets

1. SEC14-like protein 4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
SEC14-like protein 4 Q9UDX3 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

2. SEC14-like protein 3

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
SEC14-like protein 3 Q9UDX4 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Ye X, Ji C, Yin G, Tang R, Zeng L, Gu S, Ying K, Xie Y, Zhao RC, Mao Y: Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. Mol Biol Rep. 2004 Mar;31(1):59-63. Pubmed

3. SEC14-like protein 2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
SEC14-like protein 2 O76054 Details

References:

  1. Neuzil J, Dong LF, Wang XF, Zingg JM: Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells. Biochem Biophys Res Commun. 2006 May 19;343(4):1113-7. Epub 2006 Mar 31. Pubmed
  2. Ni J, Pang ST, Yeh S: Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells. Prostate. 2007 Apr 1;67(5):463-71. Pubmed

4. Nuclear receptor subfamily 1 group I member 2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Nuclear receptor subfamily 1 group I member 2 O75469 Details

References:

  1. Rabovsky A, Cuomo J, Eich N: Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects. Clin Chim Acta. 2006 Sep;371(1-2):55-60. Epub 2006 Mar 6. Pubmed
  2. Meijerman I, Beijnen JH, Schellens JH: Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist. 2006 Jul-Aug;11(7):742-52. Pubmed

5. Protein kinase C beta type

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Protein kinase C beta type P05771 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Wigg SJ, Tare M, Forbes J, Cooper ME, Thomas MC, Coleman HA, Parkington HC, O’Brien RC: Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-beta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats. Diabetologia. 2004 Jun;47(6):1038-46. Epub 2004 Jun 8. Pubmed
  4. Huang Y, Ishizuka T, Miura A, Kajita K, Ishizawa M, Kimura M, Yamamoto Y, Kawai Y, Morita H, Uno Y, Yasuda K: Effect of 1 alpha,25-dihydroxy vitamin D3 and vitamin E on insulin-induced glucose uptake in rat adipocytes. Diabetes Res Clin Pract. 2002 Mar;55(3):175-83. Pubmed
  5. Ganz MB, Seftel A: Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E. Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E146-52. Pubmed

6. Arachidonate 5-lipoxygenase

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Arachidonate 5-lipoxygenase P09917 Details

References:

  1. Taccone-Gallucci M, Manca-di-Villahermosa S, Battistini L, Stuffler RG, Tedesco M, Maccarrone M: N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity. Kidney Int. 2006 Apr;69(8):1450-4. Pubmed

7. Protein kinase C alpha type

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Protein kinase C alpha type P17252 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Azzi A, Boscoboinik D, Clement S, Marilley D, Ozer NK, Ricciarelli R, Tasinato A: Alpha-tocopherol as a modulator of smooth muscle cell proliferation. Prostaglandins Leukot Essent Fatty Acids. 1997 Oct;57(4-5):507-14. Pubmed
  4. Sylvester PW, McIntyre BS, Gapor A, Briski KP: Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. Cell Prolif. 2001 Dec;34(6):347-57. Pubmed
  5. Huang Y, Ishizuka T, Miura A, Kajita K, Ishizawa M, Kimura M, Yamamoto Y, Kawai Y, Morita H, Uno Y, Yasuda K: Effect of 1 alpha,25-dihydroxy vitamin D3 and vitamin E on insulin-induced glucose uptake in rat adipocytes. Diabetes Res Clin Pract. 2002 Mar;55(3):175-83. Pubmed

8. Diacylglycerol kinase alpha

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Diacylglycerol kinase alpha P23743 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform P62714 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

10. Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform P67775 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Enzymes

1. Glutathione S-transferase A2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inducer

Components

Name UniProt ID Details
Glutathione S-transferase A2 P09210 Details

References:

  1. Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31. Epub 2010 Feb 12. Pubmed

2. Glutathione S-transferase P

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Glutathione S-transferase P P09211 Details

References:

  1. Ralat LA, Colman RF: Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi. Biochemistry. 2006 Oct 17;45(41):12491-9. Pubmed

3. Glutathione S-transferase omega-1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Glutathione S-transferase omega-1 P78417 Details

References:

  1. Sampayo-Reyes A, Zakharyan RA: Tocopherol esters inhibit human glutathione S-transferase omega. Acta Biochim Pol. 2006;53(3):547-52. Epub 2006 Oct 1. Pubmed

4. Glutathione S-transferase Mu 3

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inducer

Components

Name UniProt ID Details
Glutathione S-transferase Mu 3 P21266 Details

References:

  1. Mustacich DJ, Gohil K, Bruno RS, Yan M, Leonard SW, Ho E, Cross CE, Traber MG: Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice. J Nutr Biochem. 2009 Jun;20(6):469-76. Epub 2008 Sep 11. Pubmed

5. Glutamate--cysteine ligase catalytic subunit

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inducer

Components

Name UniProt ID Details
Glutamate--cysteine ligase catalytic subunit P48506 Details

References:

  1. Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31. Epub 2010 Feb 12. Pubmed

6. NAD(P)H dehydrogenase [quinone] 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inducer

Components

Name UniProt ID Details
NAD(P)H dehydrogenase [quinone] 1 P15559 Details

References:

  1. Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31. Epub 2010 Feb 12. Pubmed

7. Heme oxygenase 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inducer

Components

Name UniProt ID Details
Heme oxygenase 1 P09601 Details

References:

  1. Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31. Epub 2010 Feb 12. Pubmed

8. Superoxide dismutase [Cu-Zn]

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inducer

Components

Name UniProt ID Details
Superoxide dismutase [Cu-Zn] P00441 Details

References:

  1. Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31. Epub 2010 Feb 12. Pubmed

Carriers

1. Alpha-tocopherol transfer protein

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Alpha-tocopherol transfer protein P49638 Details
Comments
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Drug created on June 13, 2005 07:24 / Updated on December 03, 2015 09:51