Isoxsuprine

Identification

Name
Isoxsuprine
Accession Number
DB08941
Type
Small Molecule
Groups
Approved, Withdrawn
Description

A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Isoxsuprine hydrochlorideV74TEQ36CO 579-56-6QVPSGVSNYPRFAS-BQZDIUEZSA-N
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Isoxsuprine HydrochlorideTablet10 mg/1OralBi Coastal Pharmaceutical Corporation2011-06-02Not applicableUs
Isoxsuprine HydrochlorideTablet10 mg/1OralEci Pharmaceuticals Llc2011-06-02Not applicableUs
Isoxsuprine HydrochlorideTablet20 mg/1OralBi Coastal Pharma International Limited Liability Company2011-06-02Not applicableUs
Isoxsuprine HydrochlorideTablet20 mg/1OralBi Coastal Pharmaceutical Corporation2011-06-02Not applicableUs
Isoxsuprine HydrochlorideTablet20 mg/1OralVedco Dba Valdar2011-08-23Not applicableUs
Isoxsuprine HydrochlorideTablet20 mg/1OralVista Pharmaceuticals, Inc.1997-09-19Not applicableUs
Isoxsuprine HydrochlorideTablet20 mg/1OralEci Pharmaceuticals Llc2011-08-23Not applicableUs
Isoxsuprine HydrochlorideTablet10 mg/1OralBi Coastal Pharma International Limited Liability Company2011-06-02Not applicableUs
Categories
UNII
R15UI3245N
CAS number
395-28-8
Weight
Average: 301.386
Monoisotopic: 301.167793605
Chemical Formula
C18H23NO3
InChI Key
BMUKKTUHUDJSNZ-HBUWYVDXSA-N
InChI
InChI=1S/C18H23NO3/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15/h3-11,13-14,18-21H,12H2,1-2H3/t13-,14-,18-/m1/s1
IUPAC Name
4-[(1S,2R)-1-hydroxy-2-{[(2R)-1-phenoxypropan-2-yl]amino}propyl]phenol
SMILES
C[[email protected]](COC1=CC=CC=C1)N[[email protected]](C)[[email protected]@H](O)C1=CC=C(O)C=C1

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AcebutololThe risk or severity of adverse effects can be increased when Acebutolol is combined with Isoxsuprine.Approved
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Isoxsuprine.Approved
AlfuzosinAlfuzosin may decrease the vasoconstricting activities of Isoxsuprine.Approved, Investigational
AliskirenThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Aliskiren.Approved, Investigational
AmifostineThe risk or severity of adverse effects can be increased when Amifostine is combined with Isoxsuprine.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Isoxsuprine.Approved
AmiodaroneThe risk or severity of adverse effects can be increased when Amiodarone is combined with Isoxsuprine.Approved, Investigational
AmlodipineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Isoxsuprine.Approved
AmobarbitalAmobarbital may increase the hypotensive activities of Isoxsuprine.Approved, Illicit
AmphetamineThe risk or severity of adverse effects can be increased when Amphetamine is combined with Isoxsuprine.Approved, Illicit
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Isoxsuprine.Approved, Investigational
Amyl NitriteThe risk or severity of adverse effects can be increased when Amyl Nitrite is combined with Isoxsuprine.Approved
ApomorphineThe risk or severity of adverse effects can be increased when Apomorphine is combined with Isoxsuprine.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Apraclonidine is combined with Isoxsuprine.Approved
AripiprazoleAripiprazole may increase the hypotensive activities of Isoxsuprine.Approved, Investigational
ArotinololThe risk or severity of adverse effects can be increased when Arotinolol is combined with Isoxsuprine.Approved
Arsenic trioxideThe risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Isoxsuprine.Approved, Investigational
AtenololThe risk or severity of adverse effects can be increased when Atenolol is combined with Isoxsuprine.Approved
AtomoxetineAtomoxetine may increase the hypertensive activities of Isoxsuprine.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Isoxsuprine.Approved
BarbexacloneBarbexaclone may increase the hypotensive activities of Isoxsuprine.Experimental
BarbitalBarbital may increase the hypotensive activities of Isoxsuprine.Illicit
BarnidipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Isoxsuprine.Approved
BenazeprilThe risk or severity of adverse effects can be increased when Benazepril is combined with Isoxsuprine.Approved, Investigational
BendroflumethiazideThe risk or severity of adverse effects can be increased when Bendroflumethiazide is combined with Isoxsuprine.Approved
BenzphetamineThe risk or severity of adverse effects can be increased when Benzphetamine is combined with Isoxsuprine.Approved, Illicit
Benzylpenicilloyl PolylysineIsoxsuprine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BepridilThe risk or severity of adverse effects can be increased when Bepridil is combined with Isoxsuprine.Approved, Withdrawn
BetaxololThe risk or severity of adverse effects can be increased when Betaxolol is combined with Isoxsuprine.Approved
BisoprololThe risk or severity of adverse effects can be increased when Bisoprolol is combined with Isoxsuprine.Approved
BortezomibThe risk or severity of adverse effects can be increased when Bortezomib is combined with Isoxsuprine.Approved, Investigational
BretyliumThe risk or severity of adverse effects can be increased when Bretylium is combined with Isoxsuprine.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Brimonidine is combined with Isoxsuprine.Approved
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Isoxsuprine.Approved, Investigational
BucindololThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Bucindolol.Investigational
BumetanideThe risk or severity of adverse effects can be increased when Bumetanide is combined with Isoxsuprine.Approved
BunazosinBunazosin may decrease the vasoconstricting activities of Isoxsuprine.Investigational
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Isoxsuprine.Approved, Investigational
CabergolineCabergoline may increase the hypertensive activities of Isoxsuprine.Approved
CanagliflozinThe risk or severity of adverse effects can be increased when Canagliflozin is combined with Isoxsuprine.Approved
CandesartanThe risk or severity of adverse effects can be increased when Candesartan is combined with Isoxsuprine.Approved
CaptoprilThe risk or severity of adverse effects can be increased when Captopril is combined with Isoxsuprine.Approved
CarbetocinThe risk or severity of adverse effects can be increased when Carbetocin is combined with Isoxsuprine.Approved
CarteololThe risk or severity of adverse effects can be increased when Carteolol is combined with Isoxsuprine.Approved
CarvedilolThe risk or severity of adverse effects can be increased when Carvedilol is combined with Isoxsuprine.Approved, Investigational
CeliprololThe risk or severity of adverse effects can be increased when Celiprolol is combined with Isoxsuprine.Approved, Investigational
ChlorothiazideThe risk or severity of adverse effects can be increased when Chlorothiazide is combined with Isoxsuprine.Approved, Vet Approved
ChlorphentermineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Isoxsuprine.Illicit, Withdrawn
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Isoxsuprine.Approved, Vet Approved
ChlorthalidoneThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Isoxsuprine.Approved
CilazaprilThe risk or severity of adverse effects can be increased when Cilazapril is combined with Isoxsuprine.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Cilnidipine is combined with Isoxsuprine.Approved
ClenbuterolThe risk or severity of adverse effects can be increased when Clenbuterol is combined with Isoxsuprine.Approved, Vet Approved
ClevidipineThe risk or severity of adverse effects can be increased when Clevidipine is combined with Isoxsuprine.Approved
ClofarabineThe risk or severity of adverse effects can be increased when Clofarabine is combined with Isoxsuprine.Approved, Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Isoxsuprine.Approved, Vet Approved
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Isoxsuprine.Approved
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Isoxsuprine.Approved
ConivaptanThe risk or severity of adverse effects can be increased when Conivaptan is combined with Isoxsuprine.Approved, Investigational
DapagliflozinThe risk or severity of adverse effects can be increased when Dapagliflozin is combined with Isoxsuprine.Approved
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Isoxsuprine.Approved
DesvenlafaxineDesvenlafaxine may increase the tachycardic activities of Isoxsuprine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Isoxsuprine.Approved, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Diclofenamide is combined with Isoxsuprine.Approved
DihydroergotamineDihydroergotamine may increase the hypertensive activities of Isoxsuprine.Approved
DiltiazemThe risk or severity of adverse effects can be increased when Diltiazem is combined with Isoxsuprine.Approved
DinutuximabThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Dinutuximab.Approved
DipyridamoleThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Isoxsuprine.Approved
DobutamineThe risk or severity of adverse effects can be increased when Dobutamine is combined with Isoxsuprine.Approved
DopamineThe risk or severity of adverse effects can be increased when Dopamine is combined with Isoxsuprine.Approved
DoxazosinThe risk or severity of adverse effects can be increased when Doxazosin is combined with Isoxsuprine.Approved
DoxofyllineThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Doxofylline.Approved
DronabinolDronabinol may increase the tachycardic activities of Isoxsuprine.Approved, Illicit
DuloxetineIsoxsuprine may increase the orthostatic hypotensive activities of Duloxetine.Approved
EfonidipineThe risk or severity of adverse effects can be increased when Efonidipine is combined with Isoxsuprine.Approved
EmpagliflozinThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Empagliflozin.Approved
EnalaprilThe risk or severity of adverse effects can be increased when Enalapril is combined with Isoxsuprine.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Enalaprilat is combined with Isoxsuprine.Approved
EpanololThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Epanolol.Experimental
EphedrineThe risk or severity of adverse effects can be increased when Ephedrine is combined with Isoxsuprine.Approved
EpinephrineThe risk or severity of adverse effects can be increased when Epinephrine is combined with Isoxsuprine.Approved, Vet Approved
EplerenoneThe risk or severity of adverse effects can be increased when Eplerenone is combined with Isoxsuprine.Approved
EpoprostenolThe risk or severity of adverse effects can be increased when Epoprostenol is combined with Isoxsuprine.Approved
EprosartanThe risk or severity of adverse effects can be increased when Eprosartan is combined with Isoxsuprine.Approved
Ergoloid mesylateErgoloid mesylate may increase the hypertensive activities of Isoxsuprine.Approved
ErgonovineErgonovine may increase the hypertensive activities of Isoxsuprine.Approved
ErgotamineErgotamine may increase the hypertensive activities of Isoxsuprine.Approved
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Isoxsuprine.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Etacrynic acid is combined with Isoxsuprine.Approved
EtilefrineThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Etilefrine.Withdrawn
FelodipineThe risk or severity of adverse effects can be increased when Felodipine is combined with Isoxsuprine.Approved, Investigational
FenoldopamThe risk or severity of adverse effects can be increased when Fenoldopam is combined with Isoxsuprine.Approved
FenoterolThe risk or severity of adverse effects can be increased when Fenoterol is combined with Isoxsuprine.Approved
FenozoloneThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Fenozolone.Experimental
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Isoxsuprine.Approved
FosinoprilThe risk or severity of adverse effects can be increased when Fosinopril is combined with Isoxsuprine.Approved
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Isoxsuprine.Approved, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Guanfacine is combined with Isoxsuprine.Approved, Investigational
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Isoxsuprine.Approved, Vet Approved
HexobarbitalHexobarbital may increase the hypotensive activities of Isoxsuprine.Approved
HydralazineThe risk or severity of adverse effects can be increased when Hydralazine is combined with Isoxsuprine.Approved
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Isoxsuprine.Approved, Vet Approved
HydroflumethiazideThe risk or severity of adverse effects can be increased when Hydroflumethiazide is combined with Isoxsuprine.Approved
HydroxyamphetamineThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Hydroxyamphetamine.Approved
IloprostThe risk or severity of adverse effects can be increased when Iloprost is combined with Isoxsuprine.Approved, Investigational
ImidaprilThe risk or severity of adverse effects can be increased when Imidapril is combined with Isoxsuprine.Investigational
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Isoxsuprine.Approved
IndapamideThe risk or severity of adverse effects can be increased when Indapamide is combined with Isoxsuprine.Approved
IndoraminThe risk or severity of adverse effects can be increased when Indoramin is combined with Isoxsuprine.Withdrawn
IobenguaneThe therapeutic efficacy of Iobenguane can be decreased when used in combination with Isoxsuprine.Approved
IrbesartanThe risk or severity of adverse effects can be increased when Irbesartan is combined with Isoxsuprine.Approved, Investigational
IsocarboxazidThe risk or severity of adverse effects can be increased when Isocarboxazid is combined with Isoxsuprine.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Isoxsuprine.Approved, Vet Approved
IsoprenalineThe risk or severity of adverse effects can be increased when Isoprenaline is combined with Isoxsuprine.Approved
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Isosorbide Dinitrate is combined with Isoxsuprine.Approved
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Isosorbide Mononitrate is combined with Isoxsuprine.Approved
IsradipineThe risk or severity of adverse effects can be increased when Isradipine is combined with Isoxsuprine.Approved
LabetalolThe risk or severity of adverse effects can be increased when Labetalol is combined with Isoxsuprine.Approved
LacidipineThe risk or severity of adverse effects can be increased when Lacidipine is combined with Isoxsuprine.Approved
LercanidipineThe risk or severity of adverse effects can be increased when Lercanidipine is combined with Isoxsuprine.Approved, Investigational
LevobunololThe risk or severity of adverse effects can be increased when Levobunolol is combined with Isoxsuprine.Approved
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Isoxsuprine.Approved
LevodopaIsoxsuprine may increase the orthostatic hypotensive activities of Levodopa.Approved
LevomilnacipranLevomilnacipran may increase the tachycardic activities of Isoxsuprine.Approved
LevosimendanThe risk or severity of adverse effects can be increased when Levosimendan is combined with Isoxsuprine.Approved, Investigational
LinezolidLinezolid may increase the hypertensive activities of Isoxsuprine.Approved, Investigational
LisinoprilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Isoxsuprine.Approved, Investigational
LofexidineThe risk or severity of adverse effects can be increased when Lofexidine is combined with Isoxsuprine.Approved, Investigational
LosartanThe risk or severity of adverse effects can be increased when Losartan is combined with Isoxsuprine.Approved
MannitolThe risk or severity of adverse effects can be increased when Mannitol is combined with Isoxsuprine.Approved, Investigational
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Isoxsuprine.Approved
MefenorexThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Mefenorex.Experimental
MephentermineThe risk or severity of adverse effects can be increased when Mephentermine is combined with Isoxsuprine.Approved
MetaraminolThe risk or severity of adverse effects can be increased when Metaraminol is combined with Isoxsuprine.Approved, Investigational
MethamphetamineThe risk or severity of adverse effects can be increased when Methamphetamine is combined with Isoxsuprine.Approved, Illicit
MethazolamideThe risk or severity of adverse effects can be increased when Methazolamide is combined with Isoxsuprine.Approved
MethohexitalMethohexital may increase the hypotensive activities of Isoxsuprine.Approved
MethoxamineThe risk or severity of adverse effects can be increased when Methoxamine is combined with Isoxsuprine.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Isoxsuprine.Approved
MethyldopaThe risk or severity of adverse effects can be increased when Methyldopa is combined with Isoxsuprine.Approved
MethylergometrineMethylergometrine may increase the hypertensive activities of Isoxsuprine.Approved
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Isoxsuprine.Approved
MetipranololThe risk or severity of adverse effects can be increased when Metipranolol is combined with Isoxsuprine.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Metolazone is combined with Isoxsuprine.Approved
MetoprololThe risk or severity of adverse effects can be increased when Metoprolol is combined with Isoxsuprine.Approved, Investigational
MidodrineThe risk or severity of adverse effects can be increased when Midodrine is combined with Isoxsuprine.Approved
MilnacipranMilnacipran may increase the tachycardic activities of Isoxsuprine.Approved
MinoxidilThe risk or severity of adverse effects can be increased when Minoxidil is combined with Isoxsuprine.Approved
MoexiprilThe risk or severity of adverse effects can be increased when Moexipril is combined with Isoxsuprine.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Isoxsuprine.Approved, Investigational
MoxonidineThe risk or severity of adverse effects can be increased when Moxonidine is combined with Isoxsuprine.Approved
NabiloneNabilone may increase the tachycardic activities of Isoxsuprine.Approved, Investigational
NadololThe risk or severity of adverse effects can be increased when Nadolol is combined with Isoxsuprine.Approved
NebivololThe risk or severity of adverse effects can be increased when Nebivolol is combined with Isoxsuprine.Approved, Investigational
NesiritideThe risk or severity of adverse effects can be increased when Nesiritide is combined with Isoxsuprine.Approved, Investigational
NicardipineThe risk or severity of adverse effects can be increased when Nicardipine is combined with Isoxsuprine.Approved
NicorandilNicorandil may increase the hypotensive activities of Isoxsuprine.Approved
NifedipineThe risk or severity of adverse effects can be increased when Nifedipine is combined with Isoxsuprine.Approved
NilvadipineThe risk or severity of adverse effects can be increased when Nilvadipine is combined with Isoxsuprine.Approved
NimodipineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Isoxsuprine.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Nisoldipine is combined with Isoxsuprine.Approved
NitrendipineThe risk or severity of adverse effects can be increased when Nitrendipine is combined with Isoxsuprine.Approved
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Isoxsuprine.Approved
NitroglycerinThe risk or severity of adverse effects can be increased when Nitroglycerin is combined with Isoxsuprine.Approved, Investigational
NitroprussideThe risk or severity of adverse effects can be increased when Nitroprusside is combined with Isoxsuprine.Approved
NorepinephrineThe risk or severity of adverse effects can be increased when Norepinephrine is combined with Isoxsuprine.Approved
NylidrinThe risk or severity of adverse effects can be increased when Nylidrin is combined with Isoxsuprine.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Obinutuzumab is combined with Isoxsuprine.Approved
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Isoxsuprine.Approved, Investigational
OrciprenalineThe risk or severity of adverse effects can be increased when Orciprenaline is combined with Isoxsuprine.Approved
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Isoxsuprine.Approved
OxymetazolineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Isoxsuprine.Approved
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Isoxsuprine.Approved, Vet Approved
PapaverineThe risk or severity of adverse effects can be increased when Papaverine is combined with Isoxsuprine.Approved
PenbutololThe risk or severity of adverse effects can be increased when Penbutolol is combined with Isoxsuprine.Approved, Investigational
PentobarbitalPentobarbital may increase the hypotensive activities of Isoxsuprine.Approved, Vet Approved
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Isoxsuprine.Approved
PhenelzineThe risk or severity of adverse effects can be increased when Phenelzine is combined with Isoxsuprine.Approved
PhenmetrazineThe risk or severity of adverse effects can be increased when Phenmetrazine is combined with Isoxsuprine.Approved, Illicit
PhenobarbitalPhenobarbital may increase the hypotensive activities of Isoxsuprine.Approved
PhenoxybenzamineThe risk or severity of adverse effects can be increased when Phenoxybenzamine is combined with Isoxsuprine.Approved
PhentermineThe risk or severity of adverse effects can be increased when Phentermine is combined with Isoxsuprine.Approved, Illicit
PhentolamineThe risk or severity of adverse effects can be increased when Phentolamine is combined with Isoxsuprine.Approved
PhenylephrineThe risk or severity of adverse effects can be increased when Phenylephrine is combined with Isoxsuprine.Approved
PhenylpropanolamineThe risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Isoxsuprine.Approved, Vet Approved, Withdrawn
PindololThe risk or severity of adverse effects can be increased when Pindolol is combined with Isoxsuprine.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Isoxsuprine.Approved
PramipexoleThe risk or severity of adverse effects can be increased when Pramipexole is combined with Isoxsuprine.Approved, Investigational
PrazosinThe risk or severity of adverse effects can be increased when Prazosin is combined with Isoxsuprine.Approved
PrenalterolThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Prenalterol.Experimental
PrimidonePrimidone may increase the hypotensive activities of Isoxsuprine.Approved, Vet Approved
ProcaterolThe risk or severity of adverse effects can be increased when Procaterol is combined with Isoxsuprine.Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Isoxsuprine.Approved, Investigational, Vet Approved
PropranololThe risk or severity of adverse effects can be increased when Propranolol is combined with Isoxsuprine.Approved, Investigational
PseudoephedrineThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Pseudoephedrine.Approved
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Isoxsuprine.Approved
QuinaprilThe risk or severity of adverse effects can be increased when Quinapril is combined with Isoxsuprine.Approved, Investigational
RacepinephrineThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Racepinephrine.Approved
RamiprilThe risk or severity of adverse effects can be increased when Ramipril is combined with Isoxsuprine.Approved
RasagilineThe risk or severity of adverse effects can be increased when Rasagiline is combined with Isoxsuprine.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Isoxsuprine.Approved
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Isoxsuprine.Approved
RiociguatThe risk or severity of adverse effects can be increased when Riociguat is combined with Isoxsuprine.Approved
RisperidoneIsoxsuprine may increase the hypotensive activities of Risperidone.Approved, Investigational
RitodrineThe risk or severity of adverse effects can be increased when Ritodrine is combined with Isoxsuprine.Approved
RopiniroleThe risk or severity of adverse effects can be increased when Ropinirole is combined with Isoxsuprine.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Isoxsuprine.Approved
RotigotineThe risk or severity of adverse effects can be increased when Rotigotine is combined with Isoxsuprine.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Isoxsuprine.Approved
SecobarbitalSecobarbital may increase the hypotensive activities of Isoxsuprine.Approved, Vet Approved
SelegilineThe risk or severity of adverse effects can be increased when Selegiline is combined with Isoxsuprine.Approved, Investigational, Vet Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Isoxsuprine.Approved, Vet Approved
SilodosinSilodosin may decrease the vasoconstricting activities of Isoxsuprine.Approved
Sodium NitriteThe risk or severity of adverse effects can be increased when Sodium Nitrite is combined with Isoxsuprine.Approved
SotalolThe risk or severity of adverse effects can be increased when Sotalol is combined with Isoxsuprine.Approved
SpironolactoneSpironolactone may decrease the vasoconstricting activities of Isoxsuprine.Approved
StreptokinaseThe risk or severity of adverse effects can be increased when Streptokinase is combined with Isoxsuprine.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Isoxsuprine.Approved, Investigational
SynephrineThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Synephrine.Experimental
TamsulosinThe risk or severity of adverse effects can be increased when Tamsulosin is combined with Isoxsuprine.Approved, Investigational
Tedizolid PhosphateTedizolid Phosphate may increase the hypertensive activities of Isoxsuprine.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Telmisartan is combined with Isoxsuprine.Approved, Investigational
TerazosinThe risk or severity of adverse effects can be increased when Terazosin is combined with Isoxsuprine.Approved
TerbutalineThe risk or severity of adverse effects can be increased when Terbutaline is combined with Isoxsuprine.Approved
TetryzolineThe risk or severity of adverse effects can be increased when Tetryzoline is combined with Isoxsuprine.Approved
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Isoxsuprine.Approved, Investigational, Withdrawn
ThiamylalThiamylal may increase the hypotensive activities of Isoxsuprine.Approved, Vet Approved
ThiopentalThiopental may increase the hypotensive activities of Isoxsuprine.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Isoxsuprine.Withdrawn
TimololThe risk or severity of adverse effects can be increased when Timolol is combined with Isoxsuprine.Approved
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Isoxsuprine.Approved
TolazolineThe risk or severity of adverse effects can be increased when Tolazoline is combined with Isoxsuprine.Approved, Vet Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Isoxsuprine.Approved, Withdrawn
TorasemideThe risk or severity of adverse effects can be increased when Torasemide is combined with Isoxsuprine.Approved
TramazolineThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Tramazoline.Investigational
TrandolaprilThe risk or severity of adverse effects can be increased when Trandolapril is combined with Isoxsuprine.Approved
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Isoxsuprine.Approved
TretinoinThe risk or severity of adverse effects can be increased when Tretinoin is combined with Isoxsuprine.Approved, Investigational, Nutraceutical
TretoquinolThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Tretoquinol.Experimental
TriamtereneThe risk or severity of adverse effects can be increased when Triamterene is combined with Isoxsuprine.Approved
TrimazosinTrimazosin may decrease the vasoconstricting activities of Isoxsuprine.Experimental
TyramineThe risk or severity of adverse effects can be increased when Tyramine is combined with Isoxsuprine.Investigational, Nutraceutical
UrapidilUrapidil may decrease the vasoconstricting activities of Isoxsuprine.Investigational
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Isoxsuprine.Approved, Investigational
VenlafaxineVenlafaxine may increase the tachycardic activities of Isoxsuprine.Approved
VerapamilThe risk or severity of adverse effects can be increased when Verapamil is combined with Isoxsuprine.Approved
Food Interactions
Not Available

References

Synthesis Reference
Not Available
General References
Not Available
External Links
ChemSpider
9954311
ATC Codes
C04AA01 — Isoxsuprine
AHFS Codes
Not Available
PDB Entries
Not Available
FDA label
Not Available
MSDS
Not Available

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TabletOral10 mg/1
TabletOral20 mg/1
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0507 mg/mLALOGPS
logP2.06ALOGPS
logP2.56ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)9.65ChemAxon
pKa (Strongest Basic)9ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area61.72 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity86.64 m3·mol-1ChemAxon
Polarizability34.12 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as phenylpropanes. These are organic compounds containing a phenylpropane moiety.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Phenylpropanes
Direct Parent
Phenylpropanes
Alternative Parents
Phenoxy compounds / Phenol ethers / Aralkylamines / Alkyl aryl ethers / 1-hydroxy-2-unsubstituted benzenoids / Secondary alcohols / 1,2-aminoalcohols / Dialkylamines / Hydrocarbon derivatives / Aromatic alcohols
Substituents
Phenylpropane / Phenol ether / Phenoxy compound / Alkyl aryl ether / Phenol / 1-hydroxy-2-unsubstituted benzenoid / Aralkylamine / Secondary alcohol / 1,2-aminoalcohol / Secondary amine
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Drug created on May 26, 2014 15:29 / Updated on October 02, 2017 06:11