Ethyl chloride

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Ethyl chloride is a local anesthetic.

Generic Name
Ethyl chloride
DrugBank Accession Number
DB13259
Background

Ethyl chloride, or chloroethane, has a chemical formula C2H5Cl. It was commonly used in the production of tetraethyllead (TEL), which is an additive for gasoline. It was also used in other commerical applications as a chemical reagent. It is still used in the treatment of cellulose to make ethylcellulose for commercial products. Ethyl chloride is used as a diagnostic tool to detect a dead tooth with nonviable pulp.

Type
Small Molecule
Groups
Approved, Experimental, Investigational
Structure
Weight
Average: 64.514
Monoisotopic: 64.007977867
Chemical Formula
C2H5Cl
Synonyms
  • chloroethane
  • Ethyl chloride
  • monochloroethane

Pharmacology

Indication

Not Available

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Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbemaciclibThe risk or severity of methemoglobinemia can be increased when Abemaciclib is combined with Ethyl chloride.
AbirateroneThe risk or severity of methemoglobinemia can be increased when Abiraterone is combined with Ethyl chloride.
AcetaminophenThe risk or severity of methemoglobinemia can be increased when Acetaminophen is combined with Ethyl chloride.
AcetazolamideThe risk or severity of methemoglobinemia can be increased when Acetazolamide is combined with Ethyl chloride.
Acetic acidThe risk or severity of methemoglobinemia can be increased when Acetic acid is combined with Ethyl chloride.
Food Interactions
No interactions found.

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Tuffner Clear SprayEthyl chloride (12 %) + Benzoin resin (3 %)AerosolTopicalMueller Sports Medicine, Inc.1970-12-312003-08-01Canada flag

Categories

ATC Codes
N01BX01 — Ethyl chloride
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as organochlorides. These are compounds containing a chemical bond between a carbon atom and a chlorine atom.
Kingdom
Organic compounds
Super Class
Organohalogen compounds
Class
Organochlorides
Sub Class
Not Available
Direct Parent
Organochlorides
Alternative Parents
Hydrocarbon derivatives / Alkyl chlorides
Substituents
Aliphatic acyclic compound / Alkyl chloride / Alkyl halide / Hydrocarbon derivative / Organochloride
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
chloroethanes (CHEBI:47554)
Affected organisms
Not Available

Chemical Identifiers

UNII
46U771ERWK
CAS number
75-00-3
InChI Key
HRYZWHHZPQKTII-UHFFFAOYSA-N
InChI
InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3
IUPAC Name
chloroethane
SMILES
CCCl

References

General References
  1. FDA Thailand Product Information: Ethyl chloride topical spray [Link]
KEGG Compound
C18248
PubChem Compound
6337
PubChem Substance
347829290
ChemSpider
6097
RxNav
4141
ChEBI
47554
ChEMBL
CHEMBL46058
Wikipedia
Chloroethane

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionPain1
4CompletedTreatmentAcute Pain1
4CompletedTreatmentPain1
4CompletedTreatmentPain / Safety Issues / Sprays1
4RecruitingOtherLocal Anaesthesia therapy / Pain / Trigger Finger1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Aerosol
AerosolTopical
Spray100 ml/100ml
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility14.1 mg/mLALOGPS
logP1.47ALOGPS
logP1.19Chemaxon
logS-0.66ALOGPS
Physiological Charge0Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity16.06 m3·mol-1Chemaxon
Polarizability6.42 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - EI-BGC-MSsplash10-004i-9000000000-189a942366091e0718c5
Mass Spectrum (Electron Ionization)MSsplash10-004i-9000000000-11f0eb48855aebd37893
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-014i-9000000000-a61b8a6c9d8d6a806ef7
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-03di-9000000000-ad5cc7fece1830824f11
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-014i-9000000000-ad0ba8abb3fdfa4294ab
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-36cd1361d11e3c9290a1
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-9d9f82bbed224aeffc4e
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-ea28ddc2b71c7ee0f817
1H NMR Spectrum1D NMRNot Applicable
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-119.255424
predicted
DeepCCS 1.0 (2019)
[M+H]+121.11089
predicted
DeepCCS 1.0 (2019)
[M+Na]+128.59593
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:38 / Updated at June 05, 2021 09:13