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Identification
NameFluticasone Propionate
Accession NumberDB00588  (APRD00065)
TypeSmall Molecule
GroupsApproved
DescriptionFluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma. Fluticasone proprionate is marketed under several different brand names such as Flonase®. Fluticasone propionate is also available as a combination product of azelastine hydrochloride and fluticasone propionate called Dymista™. Dymista™ is indicated in patients over 12 years old for symptomatic relief of seasonal allergic rhinitis.
Structure
Thumb
Synonyms
Cutivate
Fluticason
Fluticasona
Fluticasone
Fluticasone propionate
Fluticasonum
External Identifiers
  • CCI 18781
  • GW 685698X
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
CutivateLotion.5 mg/mLTopicalPharma Derm, A Division Of Nycomed Us Inc.2009-10-05Not applicableUs
CutivateLotion.5 mg/mLTopicalPharma Derm A Division Of Fougera Pharmaceuticals Inc.2009-10-05Not applicableUs
CutivateCream.5 mg/gTopicalPharma Derm A Division Of Fougera Pharmaceuticals Inc.1990-12-18Not applicableUs
CutivateCream0.05 %TopicalGlaxosmithkline Inc2004-11-082013-08-01Canada
CutivateOintment.05 mg/gTopicalPharma Derm, A Division Of Fougera Pharmaceuticals Inc.2009-12-14Not applicableUs
FlonaseSpray, metered50 ug/1NasalGlaxo Smith Kline Llc1994-11-082016-02-28Us
FlonaseSpray, metered50 ug/1NasalREMEDYREPACK INC.2013-06-112016-11-09Us
Flonase - Aem-sus Nas 50mcg/mdSpray, metered50 mcgNasalGlaxosmithkline Inc1993-03-12Not applicableCanada
Flonase Aem-sus 50mcg/aemAerosol, metered; Suspension50 mcgNasalGlaxo Canada Inc1993-12-311998-07-30Canada
Flovent DiskusPowder50 mcgRespiratory (inhalation)Glaxosmithkline Inc1998-04-022015-10-09Canada
Flovent DiskusPowder, metered50 ug/1Respiratory (inhalation)Glaxo Smith Kline Llc2007-05-08Not applicableUs
Flovent DiskusPowder100 mcgRespiratory (inhalation)Glaxosmithkline Inc1998-04-02Not applicableCanada
Flovent DiskusPowder, metered50 ug/1Respiratory (inhalation)A S Medication Solutions2007-05-08Not applicableUs
Flovent DiskusPowder, metered250 ug/1Respiratory (inhalation)Glaxo Smith Kline Llc2008-10-13Not applicableUs
Flovent DiskusPowder250 mcgRespiratory (inhalation)Glaxosmithkline Inc1998-04-02Not applicableCanada
Flovent DiskusPowder, metered100 ug/1Respiratory (inhalation)Glaxo Smith Kline Llc2008-10-13Not applicableUs
Flovent DiskusPowder500 mcgRespiratory (inhalation)Glaxosmithkline Inc1998-04-02Not applicableCanada
Flovent HFAAerosol, metered110 ug/1Respiratory (inhalation)Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC2007-01-29Not applicableUs
Flovent HFAAerosol, metered220 ug/1Respiratory (inhalation)A S Medication Solutions2007-01-25Not applicableUs
Flovent HFAAerosol, metered44 ug/1Respiratory (inhalation)Glaxo Smith Kline Llc2007-04-06Not applicableUs
Flovent HFAAerosol, metered50 mcgOral; Respiratory (inhalation)Glaxosmithkline Inc2001-12-20Not applicableCanada
Flovent HFAAerosol, metered44 ug/1Respiratory (inhalation)REMEDYREPACK INC.2013-06-11Not applicableUs
Flovent HFAAerosol, metered110 ug/1Respiratory (inhalation)Physicians Total Care, Inc.2005-07-13Not applicableUs
Flovent HFAAerosol, metered125 mcgOral; Respiratory (inhalation)Glaxosmithkline Inc2001-12-20Not applicableCanada
Flovent HFAAerosol, metered110 ug/1Respiratory (inhalation)Glaxo Smith Kline Llc2007-01-29Not applicableUs
Flovent HFAAerosol, metered110 ug/1Respiratory (inhalation)A S Medication Solutions2007-01-29Not applicableUs
Flovent HFAAerosol, metered220 ug/1Respiratory (inhalation)Physicians Total Care, Inc.2006-07-05Not applicableUs
Flovent HFAAerosol, metered220 ug/1Respiratory (inhalation)Glaxo Smith Kline Llc2007-01-25Not applicableUs
Flovent HFAAerosol, metered250 mcgOral; Respiratory (inhalation)Glaxosmithkline Inc2001-12-20Not applicableCanada
Flovent HFAAerosol, metered44 ug/1Respiratory (inhalation)A S Medication Solutions2007-04-06Not applicableUs
Flovent HFAAerosol, metered44 ug/1Respiratory (inhalation)Physicians Total Care, Inc.2009-02-26Not applicableUs
Flovent Inhalers - Aem Inh-orl 125mcg/aemAerosol, metered125 mcgOral; Respiratory (inhalation)Glaxosmithkline Inc1998-08-182003-06-10Canada
Flovent Inhalers - Aem Inh-orl 250mcg/aemAerosol, metered250 mcgOral; Respiratory (inhalation)Glaxosmithkline Inc1998-09-212003-03-27Canada
Flovent Inhalers - Aem Inh-orl 25mcg/aemAerosol, metered25 mcgOral; Respiratory (inhalation)Glaxosmithkline Inc1998-11-272003-06-10Canada
Flovent Inhalers - Aem Inh-orl 50mcg/aemAerosol, metered50 mcgOral; Respiratory (inhalation)Glaxosmithkline Inc1998-04-092003-06-10Canada
Flovent Inhalers-aem Inh-orl 25mcg/actuationAerosol, metered25 mcgOral; Respiratory (inhalation)Glaxo Canada Inc1995-12-311999-08-12Canada
Flovent Inhalers-aem Inh-orl 50mcg/actuationAerosol, metered50 mcgOral; Respiratory (inhalation)Glaxo Canada Inc1995-12-311998-07-30Canada
Flovent Inhalers-aem Inh-orl125mcg/actuationAerosol, metered125 mcgOral; Respiratory (inhalation)Glaxo Canada Inc1995-12-311999-08-12Canada
Flovent Inhalers-aem Inh-orl250mcg/actuationAerosol, metered250 mcgOral; Respiratory (inhalation)Glaxo Canada Inc1995-12-311999-08-12Canada
Fluticasone PropionateLotion.5 mg/mLTopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2009-10-05Not applicableUs
Nu-fluticasoneSpray, metered50 mcgNasalNu Pharm IncNot applicableNot applicableCanada
Ratio-fluticasoneSpray, metered50 mcgNasalTeva Canada Limited2007-06-07Not applicableCanada
Teva-fluticasoneSpray, metered50 mcgNasalTeva Canada LimitedNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-fluticasoneSpray, metered50 mcgNasalApotex Inc2007-07-05Not applicableCanada
FluticasoneSpray, metered50 ug/1NasalUnit Dose Services2012-01-09Not applicableUs
FluticasoneSpray, metered50 ug/1NasalMorton Grove Pharmaceuticals, Inc.2012-01-09Not applicableUs
FluticasoneSpray, metered50 ug/1NasalMedsource Pharmaceuticals2012-01-09Not applicableUs
FluticasoneSpray, metered50 ug/1NasalUnit Dose Services2012-01-09Not applicableUs
FluticasoneSpray, metered50 ug/1NasalDIRECT RX2014-01-01Not applicableUs
Fluticasone PropionateSpray, metered50 ug/.1gNasalLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-12Not applicableUs
Fluticasone PropionateCream.5 mg/gTopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2004-05-14Not applicableUs
Fluticasone PropionateSpray, metered50 ug/.1gNasalREMEDYREPACK INC.2013-06-11Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalGolden State Medical Supply, Inc.2011-06-02Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalREMEDYREPACK INC.2013-06-11Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalWest Ward Pharmaceuticals Corp.2006-02-22Not applicableUs
Fluticasone PropionateSpray, metered50 ug/.1gNasalRebel Distributors Corp2008-01-16Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalA S Medication Solutions2007-09-19Not applicableUs
Fluticasone PropionateLotion.5 mg/mLTopicalGlenmark Pharmaceuticals Inc., Usa2011-10-13Not applicableUs
Fluticasone PropionateSpray, metered50 ug/.1gNasalHi Tech Pharmacal Co., Inc.2008-01-16Not applicableUs
Fluticasone PropionateOintment.05 mg/gTopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2004-05-14Not applicableUs
Fluticasone PropionateSpray, metered50 ug/.1gNasalClinical Solutions Wholesale2008-01-16Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalApotex Corp.2007-09-19Not applicableUs
Fluticasone PropionateCream.5 mg/gTopicalPhysicians Total Care, Inc.2006-09-13Not applicableUs
Fluticasone PropionateCream.5 mg/gTopicalImpax Generics2004-05-142017-10-31Us
Fluticasone PropionateCream.5 mg/gTopicalA S Medication Solutions2006-09-13Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalPreferred Pharmaceuticals, Inc.2013-04-22Not applicableUs
Fluticasone PropionateLotion.5 mg/mLTopicalPerrigo New York Inc2013-08-08Not applicableUs
Fluticasone PropionateSpray, metered50 ug/.1gNasalUnit Dose Services2008-01-16Not applicableUs
Fluticasone PropionateCream.5 mg/gTopicalDIRECT RX2014-01-01Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalProficient Rx LP2007-09-19Not applicableUs
Fluticasone PropionateOintment.05 mg/gTopicalGW Laboratories, Inc2006-05-31Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalApotex Corp.2007-09-19Not applicableUs
Fluticasone PropionateOintment.05 mg/gTopicalPhysicians Total Care, Inc.2005-10-20Not applicableUs
Fluticasone PropionateCream.5 mg/gTopicalG&W Laboratories, Inc.2006-06-30Not applicableUs
Fluticasone PropionateSpray, metered50 ug/.1gNasalPreferred Pharmaceuticals, Inc2012-01-18Not applicableUs
Fluticasone PropionateOintment.05 mg/gTopicalTaro Pharmaceuticals U.S.A., Inc.2005-06-14Not applicableUs
Fluticasone PropionateCream.5 mg/gTopicalA S Medication Solutions2004-05-142017-10-31Us
Fluticasone PropionateCream.5 mg/gTopicalPerrigo New York Inc2006-09-13Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalBlenheim Pharmacal, Inc.2007-09-19Not applicableUs
Fluticasone PropionateSpray, metered50 ug/.1gNasalProficient Rx LP2008-01-16Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalPhysicians Total Care, Inc.2006-03-08Not applicableUs
Fluticasone PropionateOintment.05 mg/gTopicalPerrigo New York Inc2007-07-09Not applicableUs
TicanaseKitPure Tek Corporation2016-01-11Not applicableUs
TicasprayKitShoreline Pharmaceuticals, Inc.2016-05-10Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour Allergy NasalSpray, metered50 ug/1NasalShopko Stores Operating Co., LLC2016-08-23Not applicableUs
24 Hour Allergy NasalSpray, metered50 ug/1NasalWalgreen Company2016-05-27Not applicableUs
24 Hour Allergy NasalSpray, metered50 ug/1NasalHy Vee Inc2016-08-08Not applicableUs
24 Hour Allergy Relief NasalSpray, metered50 ug/1NasalMeijer Distribution Inc2016-11-17Not applicableUs
24 Hour Allergy Relief NasalSpray, metered50 ug/1NasalKroger Company2016-05-27Not applicableUs
Allergy NasalSpray, metered50 ug/1NasalWalgreen Company2016-07-12Not applicableUs
Allergy ReliefSpray, metered50 ug/1NasalMeijer Distribution Inc2016-05-27Not applicableUs
Allergy Relief NasalSpray, metered50 ug/1NasalPublix Super Markets Inc2016-09-08Not applicableUs
Berkley and Jensen Allergy ReliefSpray, metered50 ug/1NasalBJWC2016-06-27Not applicableUs
Careone Allergy ReliefSpray, metered50 ug/1NasalAmerican Sales Company2016-08-23Not applicableUs
Careone Fluticasone PropionateSpray, metered50 ug/1NasalAmerican Sales Company2016-06-13Not applicableUs
Childrens 24 Hour Allergy NasalSpray, metered50 ug/1NasalHy Vee Inc2016-08-23Not applicableUs
Childrens Flonase Allergy ReliefSpray, metered50 ug/1NasalGlaxo Smith Kline Consumer Healthcare Holdings (Us) Llc2016-02-29Not applicableUs
Clarispray Nasal AllergySpray, metered50 ug/1NasalBayer Health Care Llc2016-03-11Not applicableUs
Dg Health Allergy ReliefSpray, metered50 ug/1NasalDolgencorp, LLC2016-07-08Not applicableUs
Dg Health Allergy Relief NasalSpray, metered50 ug/1NasalDolgencorp, LLC2016-09-19Not applicableUs
Equaline Fluticasone PropionateSpray, metered50 ug/1NasalSupervalu Inc2016-07-20Not applicableUs
Equaline Fluticasone PropionateSpray, metered50 ug/1NasalSupervalu Inc2016-05-31Not applicableUs
Equate Allergy ReliefSpray, metered50 ug/1NasalWal Mart Stores Inc2016-05-28Not applicableUs
Flonase Allergy ReliefSpray, metered50 mcgNasalGlaxosmithkline Consumer Healthcare Inc.Not applicableNot applicableCanada
Flonase Allergy ReliefSpray, metered50 ug/1NasalGlaxo Smith Kline Consumer Healthcare Holdings (Us) Llc2014-12-04Not applicableUs
Flonaseallergy Relief Allergy ReliefSpray, metered50 ug/1NasalREMEDYREPACK INC.2016-02-15Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalMarc Glassman, Inc.2016-03-28Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalWalgreens2016-05-27Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalSafeway2016-08-15Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalApotex Corp.2016-05-31Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalFreds Inc2016-11-28Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalRugby Laboratories2016-02-29Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalQuality Home Products2016-09-16Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalDiscount Drug Mart2016-08-30Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalCVS Pharmacy2016-07-25Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalRite Aid Corporation2016-03-14Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalCVS Pharmacy2016-02-29Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalChain Drugs Consortium, Llc2016-02-29Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalCVS Pharmacy2016-09-15Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalTopco Associates LLC2016-09-15Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalChain Drug Marketing Association2016-08-15Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalRite Aid2016-09-18Not applicableUs
Fluticasone PropionateSpray, metered50 ug/1NasalWalmart2016-11-09Not applicableUs
Fluticasone Propionate GlucocorticoidSpray, metered50 ug/1NasalPerrigo New York Inc2016-08-25Not applicableUs
Good Neighbor Pharmacy Childrens Fluticasone PropionateSpray, metered50 ug/1NasalAmerisource Bergen2016-10-10Not applicableUs
Good Neighbor Pharmacy Fluticasone PropionateSpray, metered50 ug/1NasalAmerisource Bergen2016-05-29Not applicableUs
Good Sense 24 Hour Allergy NasalSpray, metered50 ug/1NasalL. Perrigo Company2016-08-03Not applicableUs
Good Sense NasoflowSpray, metered50 ug/1NasalL. Perrigo Company2016-05-27Not applicableUs
Harris Teeter Allergy Relief NasalSpray, metered50 ug/1NasalHarris Teeter, LLC2016-07-31Not applicableUs
Health Mart Allergy Relief Nasal 24 HrSpray, metered50 ug/1NasalMcKesson2016-05-29Not applicableUs
Healthy Accents Allergy ReliefSpray, metered50 ug/1NasalDZA Brands LLC2016-07-29Not applicableUs
Healthy Accents NasoflowSpray, metered50 ug/1NasalDZA Brands LLC2016-07-22Not applicableUs
Kirkland Signature Aller FloSpray, metered50 ug/1NasalCostco Wholesale Company2016-05-29Not applicableUs
Leader Allergy Relief NasalSpray, metered50 ug/1NasalCardinal Health2016-05-27Not applicableUs
NasoflowSpray, metered50 ug/1NasalShopko Stores Operating Co., LLC2016-06-01Not applicableUs
NasoflowSpray, metered50 ug/1NasalHy Vee Inc2016-05-31Not applicableUs
NasoflowSpray, metered50 ug/1NasalH E B2016-05-30Not applicableUs
NasoflowSpray, metered50 ug/1NasalPublix Super Markets Inc2016-05-31Not applicableUs
Shoprite Allergy Relief NasalSpray, metered50 ug/1NasalWakefern Food Corporation2016-07-07Not applicableUs
Signature Care Allergy ReliefSpray, metered50 ug/1NasalSafeway2016-05-31Not applicableUs
Smart Sense Allergy ReliefSpray, metered50 ug/1NasalKmart Corporation2016-06-10Not applicableUs
Sunmark Allergy Relief Nasal 24 HrSpray, metered50 ug/1NasalMcKesson2015-05-29Not applicableUs
Topcare Childrens Allergy Relief Nasal 24 HourSpray, metered50 ug/1NasalTopco Associates LLC2016-07-28Not applicableUs
Topcare Fluticasone Propionate NasalSpray, metered50 ug/1NasalTopco Associates LLC2016-06-24Not applicableUs
Topcare Nasoflow Allergy ReliefSpray, metered50 ug/1NasalTopco Associates LLC2016-05-27Not applicableUs
Up and Up Allergy Relief NasalSpray, metered50 ug/1NasalTarget Corporation2016-05-31Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
EzicasIntas
FlixonaseGlaxoSmithKline
FlixotideGlaxoSmithKline
FloventGlaxoSmithKline
FLOVENTHFANot Available
FlunaseGlaxoSmithKline
NasofanTeva
PirinaseGlaxoSmithKline
SeretideGlaxoSmithKline
Brand mixtures
NameLabellerIngredients
Advair 100 DiskusGlaxosmithkline Inc
Advair 125Glaxosmithkline Inc
Advair 250Glaxosmithkline Inc
Advair 250 DiskusGlaxosmithkline Inc
Advair 500 DiskusGlaxosmithkline Inc
Advair DiskusGlaxo Smith Kline Llc
Advair HFAGlaxo Smith Kline Llc
Advairdiskus DiskusREMEDYREPACK INC.
DymistaMeda Pharmaceuticals Inc.
TicalastShoreline Pharmaceuticals, Inc.
SaltsNot Available
Categories
UNIIO2GMZ0LF5W
CAS number80474-14-2
WeightAverage: 500.571
Monoisotopic: 500.184429407
Chemical FormulaC25H31F3O5S
InChI KeyWMWTYOKRWGGJOA-CENSZEJFSA-N
InChI
InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
IUPAC Name
(1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-14-yl propanoate
SMILES
[H][C@@]12C[C@@H](C)[C@](OC(=O)CC)(C(=O)SCF)[C@@]1(C)C[[email protected]](O)[C@@]1(F)[C@@]2([H])C[[email protected]](F)C2=CC(=O)C=C[C@]12C
Pharmacology
IndicationFluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma.
Structured Indications
PharmacodynamicsFluticasone is an extremely potent vasoconstrictor and anti-inflammatory agent. Its effectiveness in inhaled forms is due to its direct local effect.
Mechanism of actionBinds to the glucocorticoid receptor. Unbound corticosteroids cross the membranes of cells such as mast cells and eosinophils, binding with high affinity to glucocorticoid receptors (GR). The results include alteration of transcription and protein synthesis, a decreased release of leukocytic acid hydrolases, reduction in fibroblast proliferation, prevention of macrophage accumulation at inflamed sites, reduction of collagen deposition, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability and subsequent edema, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. In the management of asthma, the glucocorticoid receptor complexes down-regulates proinflammatory mediators such as interleukin-(IL)-1, 3, and 5, and up-regulates anti-inflammatory mediators such as IkappaB [inhibitory molecule for nuclear factor kappaB1], IL-10, and IL-12. The antiinflammatory actions of corticosteroids are also thought to involve inhibition of cytosolic phospholipase A2 (through activation of lipocortin-1 (annexin)) which controls the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
TargetKindPharmacological actionActionsOrganismUniProt ID
Glucocorticoid receptorProteinyes
agonist
HumanP04150 details
Progesterone receptorProteinunknown
agonist
HumanP06401 details
Cytosolic phospholipase A2Proteinunknown
inhibitor
HumanP47712 details
Mineralocorticoid receptorProteinunknown
antagonist
HumanP08235 details
Related Articles
AbsorptionThe extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Bioavailability, intranasal = <2%; Oral bioavailability is negligible and the major circulating entity is an inactive metabolite.
Volume of distribution

IV administration = 4.2 L/kg

Protein binding91%
Metabolism

Fluticasone propionate is metabolized in the liver by cytochrome P450 3A4-mediated hydrolysis of the 5-fluoromethyl carbothioate grouping. This transformation occurs in 1 metabolic step to produce the inactive 17-(beta)-carboxylic acid metabolite, the only known metabolite detected in man.

SubstrateEnzymesProduct
Fluticasone Propionate
fluticasone 17beta-carboxylic acidDetails
Route of eliminationLess than 5% of the oral dose was excreted in the urine as metabolites. The rest of the dose is excreted in the feces and parent drug and metabolites.
Half lifeTerminal elimination half-life = 7.8 hours
Clearance

The total blood clearance of fluticasone propionate is high (average, 1,093 mL/min), with renal clearance accounting for less than 0.02% of the total.

ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with 1,1,1,2 Tetrafluoroethane.Investigational
1,10-PhenanthrolineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with 1,10-Phenanthroline.Experimental
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Fluticasone Propionate.Experimental
AceclofenacThe risk or severity of adverse effects can be increased when Aceclofenac is combined with Fluticasone Propionate.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fluticasone Propionate.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fluticasone Propionate.Approved
AcetovanilloneThe risk or severity of adverse effects can be increased when Acetovanillone is combined with Fluticasone Propionate.Investigational
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Fluticasone Propionate.Approved, Vet Approved
AdapaleneThe risk or severity of adverse effects can be increased when Adapalene is combined with Fluticasone Propionate.Approved
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Fluticasone Propionate.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Fluticasone Propionate.Approved, Investigational
AldesleukinFluticasone Propionate may decrease the antineoplastic activities of Aldesleukin.Approved
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Fluticasone Propionate.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Fluticasone Propionate.Approved, Illicit
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Fluticasone Propionate.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fluticasone Propionate.Approved, Illicit, Investigational
ALT-110The risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with ALT-110.Investigational
Aluminum hydroxideThe bioavailability of Fluticasone Propionate can be decreased when combined with Aluminum hydroxide.Approved
Aluminum phosphateThe bioavailability of Fluticasone Propionate can be decreased when combined with Aluminum phosphate.Approved
AmbenoniumThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ambenonium.Approved
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Aminosalicylic Acid is combined with Fluticasone Propionate.Approved
AmiodaroneThe serum concentration of Fluticasone Propionate can be increased when it is combined with Amiodarone.Approved, Investigational
AmiodaroneThe metabolism of Fluticasone Propionate can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Fluticasone Propionate.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Fluticasone Propionate.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Fluticasone Propionate.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Fluticasone Propionate.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Fluticasone Propionate.Experimental
Amphotericin BFluticasone Propionate may increase the hypokalemic activities of Amphotericin B.Approved, Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Anisodamine is combined with Fluticasone Propionate.Investigational
AntipyrineThe risk or severity of adverse effects can be increased when Antipyrine is combined with Fluticasone Propionate.Approved
ApremilastThe risk or severity of adverse effects can be increased when Apremilast is combined with Fluticasone Propionate.Approved, Investigational
AprepitantThe serum concentration of Fluticasone Propionate can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Fluticasone Propionate.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Fluticasone Propionate.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Fluticasone Propionate.Approved
AtazanavirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Atazanavir.Approved, Investigational
AtazanavirThe metabolism of Fluticasone Propionate can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Fluticasone Propionate can be decreased when combined with Atomoxetine.Approved
Atracurium besylateAtracurium besylate may increase the adverse neuromuscular activities of Fluticasone Propionate.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Fluticasone Propionate.Vet Approved
AzapropazoneThe risk or severity of adverse effects can be increased when Azapropazone is combined with Fluticasone Propionate.Withdrawn
AzelastineFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Fluticasone Propionate.Approved
BalsalazideThe risk or severity of adverse effects can be increased when Balsalazide is combined with Fluticasone Propionate.Approved, Investigational
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Fluticasone Propionate.Illicit
BazedoxifeneThe serum concentration of Fluticasone Propionate can be increased when it is combined with Bazedoxifene.Approved, Investigational
BendroflumethiazideFluticasone Propionate may increase the hypokalemic activities of Bendroflumethiazide.Approved
BenoxaprofenThe risk or severity of adverse effects can be increased when Benoxaprofen is combined with Fluticasone Propionate.Withdrawn
BenperidolThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Fluticasone Propionate.Approved
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be decreased when used in combination with Fluticasone Propionate.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Fluticasone Propionate.Approved
Betulinic AcidThe risk or severity of adverse effects can be increased when Betulinic Acid is combined with Fluticasone Propionate.Investigational
BexaroteneThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Bexarotene.Approved, Investigational
Bismuth SubcitrateThe bioavailability of Fluticasone Propionate can be decreased when combined with Bismuth Subcitrate.Approved
BoceprevirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Boceprevir.Approved
BoceprevirThe metabolism of Fluticasone Propionate can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Fluticasone Propionate can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Bosentan.Approved, Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Brimonidine is combined with Fluticasone Propionate.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Fluticasone Propionate.Approved, Illicit
BromfenacThe risk or severity of adverse effects can be increased when Bromfenac is combined with Fluticasone Propionate.Approved
BrompheniramineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Fluticasone Propionate.Approved, Withdrawn
BucillamineThe risk or severity of adverse effects can be increased when Bucillamine is combined with Fluticasone Propionate.Investigational
BumetanideFluticasone Propionate may increase the hypokalemic activities of Bumetanide.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fluticasone Propionate.Approved, Investigational
BuprenorphineFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Fluticasone Propionate.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Fluticasone Propionate.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Fluticasone Propionate.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Fluticasone Propionate.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Fluticasone Propionate.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Fluticasone Propionate.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Fluticasone Propionate.Approved, Illicit, Vet Approved
CalcitriolThe therapeutic efficacy of Calcitriol can be decreased when used in combination with Fluticasone Propionate.Approved, Nutraceutical
Calcium carbonateThe bioavailability of Fluticasone Propionate can be decreased when combined with Calcium carbonate.Approved
CarbamazepineThe metabolism of Fluticasone Propionate can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fluticasone Propionate.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Fluticasone Propionate.Approved
CarprofenThe risk or severity of adverse effects can be increased when Carprofen is combined with Fluticasone Propionate.Approved, Vet Approved, Withdrawn
CastanospermineThe risk or severity of adverse effects can be increased when Castanospermine is combined with Fluticasone Propionate.Experimental
CDX-110The risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with CDX-110.Investigational
CelecoxibThe risk or severity of adverse effects can be increased when Celecoxib is combined with Fluticasone Propionate.Approved, Investigational
CeritinibThe serum concentration of Fluticasone Propionate can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Fluticasone Propionate.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluticasone Propionate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fluticasone Propionate.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fluticasone Propionate.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Fluticasone Propionate.Approved
ChloroquineThe risk or severity of adverse effects can be increased when Chloroquine is combined with Fluticasone Propionate.Approved, Vet Approved
ChlorothiazideFluticasone Propionate may increase the hypokalemic activities of Chlorothiazide.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Fluticasone Propionate can be increased when it is combined with Chlorotrianisene.Withdrawn
ChlorphenamineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Fluticasone Propionate.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Fluticasone Propionate.Approved, Withdrawn
ChlorthalidoneFluticasone Propionate may increase the hypokalemic activities of Chlorthalidone.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Fluticasone Propionate.Approved
CholestyramineCholestyramine can cause a decrease in the absorption of Fluticasone Propionate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Fluticasone Propionate.Approved, Vet Approved
CinoxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Cinoxacin.Approved, Withdrawn
CiprofloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ciprofloxacin.Approved, Investigational
CitalopramThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Citalopram.Approved
ClarithromycinThe serum concentration of Fluticasone Propionate can be increased when it is combined with Clarithromycin.Approved
ClarithromycinThe metabolism of Fluticasone Propionate can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Fluticasone Propionate can be decreased when combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Fluticasone Propionate.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Fluticasone Propionate.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Fluticasone Propionate.Approved
ClonixinThe risk or severity of adverse effects can be increased when Clonixin is combined with Fluticasone Propionate.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Fluticasone Propionate.Approved, Illicit
ClotrimazoleThe metabolism of Fluticasone Propionate can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Fluticasone Propionate.Approved
CobicistatThe serum concentration of Fluticasone Propionate can be increased when it is combined with Cobicistat.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Fluticasone Propionate.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Fluticasone Propionate.Approved, Illicit
ColesevelamColesevelam can cause a decrease in the absorption of Fluticasone Propionate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Fluticasone Propionate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ConivaptanThe serum concentration of Fluticasone Propionate can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Fluticasone Propionate can be increased when it is combined with Conjugated Equine Estrogens.Approved
Corticorelin ovine triflutateThe therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluticasone Propionate.Approved
CoumaphosThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Coumaphos.Vet Approved
CrizotinibThe metabolism of Fluticasone Propionate can be decreased when combined with Crizotinib.Approved
CurcuminThe risk or severity of adverse effects can be increased when Curcumin is combined with Fluticasone Propionate.Investigational
CyclizineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fluticasone Propionate.Approved
CyclosporineThe metabolism of Fluticasone Propionate can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Fluticasone Propionate.Approved
D-LimoneneThe risk or severity of adverse effects can be increased when D-Limonene is combined with Fluticasone Propionate.Investigational
DabrafenibThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Dabrafenib.Approved
DantroleneThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Fluticasone Propionate.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Dapoxetine.Investigational
DarunavirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Darunavir.Approved
DarunavirThe metabolism of Fluticasone Propionate can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Fluticasone Propionate can be increased when it is combined with Dasatinib.Approved, Investigational
DecamethoniumThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Decamethonium.Approved
DeferasiroxThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Fluticasone Propionate can be decreased when combined with Delavirdine.Approved
DemecariumThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Demecarium.Approved
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Fluticasone Propionate.Investigational
dersalazineThe risk or severity of adverse effects can be increased when dersalazine is combined with Fluticasone Propionate.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Fluticasone Propionate.Approved
DesipramineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Fluticasone Propionate.Vet Approved
DexamethasoneThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Fluticasone Propionate.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Fluticasone Propionate.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Fluticasone Propionate.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Fluticasone Propionate.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Fluticasone Propionate.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Fluticasone Propionate.Approved, Illicit, Vet Approved
DichlorvosThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Dichlorvos.Vet Approved
DiclofenacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Fluticasone Propionate.Approved, Vet Approved
DienestrolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Dienestrol.Approved
DiethylstilbestrolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Diethylstilbestrol.Approved
DifenoxinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Difenoxin.Approved, Illicit
DiflunisalThe risk or severity of adverse effects can be increased when Diflunisal is combined with Fluticasone Propionate.Approved
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Fluticasone Propionate.Approved, Illicit
DihydroergotamineThe metabolism of Fluticasone Propionate can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Fluticasone Propionate.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Fluticasone Propionate.Experimental, Illicit
DihydrotestosteroneFluticasone Propionate may increase the fluid retaining activities of Dihydrotestosterone.Illicit
DiltiazemThe metabolism of Fluticasone Propionate can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fluticasone Propionate.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Fluticasone Propionate.Approved, Illicit
DonepezilThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Donepezil.Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Fluticasone Propionate.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Doxepin.Approved
DoxycyclineThe metabolism of Fluticasone Propionate can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Fluticasone Propionate.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved, Illicit
DronedaroneThe metabolism of Fluticasone Propionate can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Fluticasone Propionate.Experimental, Illicit
DroxicamThe risk or severity of adverse effects can be increased when Droxicam is combined with Fluticasone Propionate.Approved
DuloxetineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Duloxetine.Approved
DuvelisibThe risk or severity of adverse effects can be increased when Duvelisib is combined with Fluticasone Propionate.Investigational
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Fluticasone Propionate.Approved
E6201The risk or severity of adverse effects can be increased when E6201 is combined with Fluticasone Propionate.Investigational
EbselenThe risk or severity of adverse effects can be increased when Ebselen is combined with Fluticasone Propionate.Investigational
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Fluticasone Propionate.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Fluticasone Propionate.Experimental
EchothiophateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Echothiophate.Approved
EcopipamThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ecopipam.Investigational
EdrophoniumThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Edrophonium.Approved
EfavirenzThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Efavirenz.Approved, Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Fluticasone Propionate.Approved, Vet Approved
EnoxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Enoxacin.Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Fluticasone Propionate.Approved, Investigational
EnzalutamideThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Enzalutamide.Approved
EpirizoleThe risk or severity of adverse effects can be increased when Epirizole is combined with Fluticasone Propionate.Approved
ErythromycinThe metabolism of Fluticasone Propionate can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Fluticasone Propionate.Approved, Illicit
EstradiolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Estradiol.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Fluticasone Propionate can be increased when it is combined with Estrone.Approved
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Fluticasone Propionate.Approved
Etacrynic acidFluticasone Propionate may increase the hypokalemic activities of Etacrynic acid.Approved
EtanerceptThe risk or severity of adverse effects can be increased when Etanercept is combined with Fluticasone Propionate.Approved, Investigational
EthanolFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Fluticasone Propionate.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Ethinyl Estradiol.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Fluticasone Propionate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Fluticasone Propionate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Fluticasone Propionate.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Fluticasone Propionate.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Fluticasone Propionate.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Fluticasone Propionate.Approved
EtodolacThe risk or severity of adverse effects can be increased when Etodolac is combined with Fluticasone Propionate.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Etofenamate is combined with Fluticasone Propionate.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Fluticasone Propionate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Etoperidone.Approved
EtoricoxibThe risk or severity of adverse effects can be increased when Etoricoxib is combined with Fluticasone Propionate.Approved, Investigational
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Fluticasone Propionate.Illicit, Vet Approved
EtravirineThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Etravirine.Approved
Evening primrose oilThe risk or severity of adverse effects can be increased when Evening primrose oil is combined with Fluticasone Propionate.Approved
exisulindThe risk or severity of adverse effects can be increased when exisulind is combined with Fluticasone Propionate.Investigational
EzogabineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Felbamate.Approved
FenbufenThe risk or severity of adverse effects can be increased when Fenbufen is combined with Fluticasone Propionate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Fluticasone Propionate.Approved, Illicit, Withdrawn
FenoprofenThe risk or severity of adverse effects can be increased when Fenoprofen is combined with Fluticasone Propionate.Approved
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Fluticasone Propionate.Approved, Illicit, Investigational, Vet Approved
FenthionThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Fenthion.Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Fexofenadine.Approved
FleroxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Fleroxacin.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Flibanserin.Approved
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluticasone Propionate.Approved, Withdrawn
FluconazoleThe metabolism of Fluticasone Propionate can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Fluticasone Propionate.Approved, Illicit
FlumequineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Flumequine.Withdrawn
FlunarizineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Fluticasone Propionate.Approved, Illicit
FlunixinThe risk or severity of adverse effects can be increased when Flunixin is combined with Fluticasone Propionate.Vet Approved
FluoxetineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Fluoxetine.Approved, Vet Approved
FluoxymesteroneFluticasone Propionate may increase the fluid retaining activities of Fluoxymesterone.Approved, Illicit
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Fluticasone Propionate.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Fluticasone Propionate.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Fluticasone Propionate.Approved, Illicit
FlurbiprofenThe risk or severity of adverse effects can be increased when Flurbiprofen is combined with Fluticasone Propionate.Approved, Investigational
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Fluticasone Propionate.Approved
FluvoxamineThe metabolism of Fluticasone Propionate can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Fluticasone Propionate can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Fluticasone Propionate can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Fluticasone Propionate can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Fluticasone Propionate.Approved, Illicit
FurosemideFluticasone Propionate may increase the hypokalemic activities of Furosemide.Approved, Vet Approved
Fusidic AcidThe serum concentration of Fluticasone Propionate can be increased when it is combined with Fusidic Acid.Approved
G17DTThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with G17DT.Investigational
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Fluticasone Propionate.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with gabapentin enacarbil.Approved
GalantamineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Galantamine.Approved
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Gallamine Triethiodide.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Fluticasone Propionate.Approved, Illicit
GarenoxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Garenoxacin.Investigational
GatifloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Gatifloxacin.Approved, Investigational
GemifloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Gemifloxacin.Approved, Investigational
GenisteinThe serum concentration of Fluticasone Propionate can be increased when it is combined with Genistein.Investigational
GepironeThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Gepirone.Investigational
GI-5005The risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with GI-5005.Investigational
Ginkgo bilobaThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ginkgo biloba.Approved, Nutraceutical
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluticasone Propionate.Approved, Illicit
Glycerol PhenylbutyrateThe therapeutic efficacy of Glycerol Phenylbutyrate can be decreased when used in combination with Fluticasone Propionate.Approved
GrepafloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Grepafloxacin.Withdrawn
GuanfacineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Fluticasone Propionate.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Fluticasone Propionate.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Fluticasone Propionate.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Fluticasone Propionate.Approved, Illicit
HexestrolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Hexestrol.Withdrawn
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Fluticasone Propionate.Approved
HigenamineThe risk or severity of adverse effects can be increased when Higenamine is combined with Fluticasone Propionate.Investigational
HMPL-004The risk or severity of adverse effects can be increased when HMPL-004 is combined with Fluticasone Propionate.Investigational
Huperzine AThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Huperzine A.Investigational
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Fluticasone Propionate.Approved, Investigational
HydrochlorothiazideFluticasone Propionate may increase the hypokalemic activities of Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideFluticasone Propionate may increase the hypokalemic activities of Hydroflumethiazide.Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Fluticasone Propionate.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved
IbuprofenThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Fluticasone Propionate.Approved
IbuproxamThe risk or severity of adverse effects can be increased when Ibuproxam is combined with Fluticasone Propionate.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Icatibant is combined with Fluticasone Propionate.Approved
IdelalisibThe serum concentration of Fluticasone Propionate can be increased when it is combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Iloperidone.Approved
ImatinibThe metabolism of Fluticasone Propionate can be decreased when combined with Imatinib.Approved
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Fluticasone Propionate.Approved
IndacaterolIndacaterol may increase the hypokalemic activities of Fluticasone Propionate.Approved
IndalpineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Indalpine.Investigational, Withdrawn
IndapamideFluticasone Propionate may increase the hypokalemic activities of Indapamide.Approved
IndinavirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Indinavir.Approved
IndinavirThe metabolism of Fluticasone Propionate can be decreased when combined with Indinavir.Approved
IndomethacinThe risk or severity of adverse effects can be increased when Indomethacin is combined with Fluticasone Propionate.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Indoprofen is combined with Fluticasone Propionate.Withdrawn
INGN 201The risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with INGN 201.Investigational
INGN 225The risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with INGN 225.Investigational
IsavuconazoniumThe metabolism of Fluticasone Propionate can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Fluticasone Propionate.Approved, Vet Approved
IsoflurophateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Isoflurophate.Approved, Withdrawn
IsoniazidThe serum concentration of Isoniazid can be decreased when it is combined with Fluticasone Propionate.Approved
IsoxicamThe risk or severity of adverse effects can be increased when Isoxicam is combined with Fluticasone Propionate.Withdrawn
IsradipineThe metabolism of Fluticasone Propionate can be decreased when combined with Isradipine.Approved
ItraconazoleThe serum concentration of Fluticasone Propionate can be increased when it is combined with Itraconazole.Approved, Investigational
ItraconazoleThe metabolism of Fluticasone Propionate can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Fluticasone Propionate can be increased when it is combined with Ivacaftor.Approved
KebuzoneThe risk or severity of adverse effects can be increased when Kebuzone is combined with Fluticasone Propionate.Experimental
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Fluticasone Propionate.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Fluticasone Propionate.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Fluticasone Propionate.Approved
KetoconazoleThe serum concentration of Fluticasone Propionate can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoconazoleThe metabolism of Fluticasone Propionate can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenThe risk or severity of adverse effects can be increased when Ketoprofen is combined with Fluticasone Propionate.Approved, Vet Approved
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Fluticasone Propionate.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Fluticasone Propionate.Approved, Investigational
LeflunomideThe risk or severity of adverse effects can be increased when Leflunomide is combined with Fluticasone Propionate.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Fluticasone Propionate.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Levodopa.Approved
LevofloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Fluticasone Propionate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Fluticasone Propionate.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fluticasone Propionate.Approved, Vet Approved
LisofyllineThe risk or severity of adverse effects can be increased when Lisofylline is combined with Fluticasone Propionate.Investigational
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Fluticasone Propionate.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Fluticasone Propionate.Illicit
LomefloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Lomefloxacin.Approved
LopinavirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Lopinavir.Approved
LopinavirThe metabolism of Fluticasone Propionate can be decreased when combined with Lopinavir.Approved
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Fluticasone Propionate.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fluticasone Propionate.Approved
LornoxicamThe risk or severity of adverse effects can be increased when Lornoxicam is combined with Fluticasone Propionate.Approved
LovastatinThe metabolism of Fluticasone Propionate can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Loxapine.Approved
LoxoprofenThe risk or severity of adverse effects can be increased when Loxoprofen is combined with Fluticasone Propionate.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Fluticasone Propionate.Investigational
LuliconazoleThe serum concentration of Fluticasone Propionate can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Fluticasone Propionate can be increased when combined with Lumacaftor.Approved
LumiracoxibThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluticasone Propionate.Approved, Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Fluticasone Propionate.Approved
MagaldrateThe bioavailability of Fluticasone Propionate can be decreased when combined with Magaldrate.Withdrawn
Magnesium carbonateThe bioavailability of Fluticasone Propionate can be decreased when combined with Magnesium carbonate.Approved
Magnesium hydroxideThe bioavailability of Fluticasone Propionate can be decreased when combined with Magnesium hydroxide.Approved
Magnesium oxideThe bioavailability of Fluticasone Propionate can be decreased when combined with Magnesium oxide.Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Fluticasone Propionate.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved, Vet Approved
Magnesium TrisilicateThe bioavailability of Fluticasone Propionate can be decreased when combined with Magnesium Trisilicate.Approved
MalathionThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Malathion.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Maprotiline.Approved
MasoprocolThe risk or severity of adverse effects can be increased when Masoprocol is combined with Fluticasone Propionate.Approved
MeclizineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Meclizine.Approved
Meclofenamic acidThe risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Fluticasone Propionate.Approved, Vet Approved
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Fluticasone Propionate.Vet Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Mefenamic acid is combined with Fluticasone Propionate.Approved
MefloquineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Mefloquine.Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Fluticasone Propionate.Approved, Nutraceutical, Vet Approved
MeloxicamThe risk or severity of adverse effects can be increased when Meloxicam is combined with Fluticasone Propionate.Approved, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Fluticasone Propionate.Approved
MemantineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Memantine.Approved, Investigational
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Fluticasone Propionate.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Fluticasone Propionate.Approved, Illicit
MesalazineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluticasone Propionate.Approved
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Fluticasone Propionate.Approved
MestranolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Mestranol.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Fluticasone Propionate.Withdrawn
MetaxaloneThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Fluticasone Propionate.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fluticasone Propionate.Approved, Illicit
MethallenestrilThe serum concentration of Fluticasone Propionate can be increased when it is combined with Methallenestril.Experimental
Methanesulfonyl FluorideThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Methanesulfonyl Fluoride.Investigational
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Fluticasone Propionate.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Fluticasone Propionate.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Fluticasone Propionate.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Fluticasone Propionate.Approved
MethotrimeprazineFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Fluticasone Propionate.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Methsuximide.Approved
MethyclothiazideFluticasone Propionate may increase the hypokalemic activities of Methyclothiazide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Fluticasone Propionate.Approved
MethyltestosteroneFluticasone Propionate may increase the fluid retaining activities of Methyltestosterone.Approved
MetolazoneFluticasone Propionate may increase the hypokalemic activities of Metolazone.Approved
MetyrosineFluticasone Propionate may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Fluticasone Propionate.Approved, Illicit
MifepristoneThe therapeutic efficacy of Fluticasone Propionate can be decreased when used in combination with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Milnacipran.Approved
MinaprineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Minaprine.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved, Investigational
MirtazapineFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Mitotane.Approved
MivacuriumMivacurium may increase the adverse neuromuscular activities of Fluticasone Propionate.Approved
MizoribineThe risk or severity of adverse effects can be increased when Mizoribine is combined with Fluticasone Propionate.Investigational
ModafinilThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Fluticasone Propionate.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Fluticasone Propionate.Approved, Investigational
MoxifloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Fluticasone Propionate.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Fluticasone Propionate.Approved
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved, Investigational
NabumetoneThe risk or severity of adverse effects can be increased when Nabumetone is combined with Fluticasone Propionate.Approved
NafamostatThe risk or severity of adverse effects can be increased when Nafamostat is combined with Fluticasone Propionate.Investigational
NafcillinThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Nafcillin.Approved
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Fluticasone Propionate.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Fluticasone Propionate.Approved
Nalidixic AcidThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Nalidixic Acid.Approved
NaproxenThe risk or severity of adverse effects can be increased when Naproxen is combined with Fluticasone Propionate.Approved, Vet Approved
NCX 4016The risk or severity of adverse effects can be increased when NCX 4016 is combined with Fluticasone Propionate.Investigational
NefazodoneThe serum concentration of Fluticasone Propionate can be increased when it is combined with Nefazodone.Approved, Withdrawn
NefazodoneThe metabolism of Fluticasone Propionate can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Nelfinavir.Approved
NelfinavirThe metabolism of Fluticasone Propionate can be decreased when combined with Nelfinavir.Approved
NemonoxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Nemonoxacin.Investigational
NeostigmineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Neostigmine.Approved, Vet Approved
NepafenacThe risk or severity of adverse effects can be increased when Nepafenac is combined with Fluticasone Propionate.Approved
NetupitantThe serum concentration of Fluticasone Propionate can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Fluticasone Propionate can be increased when combined with Nevirapine.Approved
NicorandilThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Nicorandil.Approved
Niflumic AcidThe risk or severity of adverse effects can be increased when Niflumic Acid is combined with Fluticasone Propionate.Approved
NilotinibThe metabolism of Fluticasone Propionate can be decreased when combined with Nilotinib.Approved, Investigational
NimesulideThe risk or severity of adverse effects can be increased when Nimesulide is combined with Fluticasone Propionate.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Fluticasone Propionate.Approved
NitroaspirinThe risk or severity of adverse effects can be increased when Nitroaspirin is combined with Fluticasone Propionate.Investigational
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fluticasone Propionate.Approved, Vet Approved
NorfloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Norfloxacin.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Fluticasone Propionate.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Fluticasone Propionate.Approved
OfloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ofloxacin.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Fluticasone Propionate.Approved, Investigational
OlaparibThe metabolism of Fluticasone Propionate can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Olopatadine.Approved
OlsalazineThe risk or severity of adverse effects can be increased when Olsalazine is combined with Fluticasone Propionate.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Fluticasone Propionate.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Fluticasone Propionate.Approved, Illicit
OrgoteinThe risk or severity of adverse effects can be increased when Orgotein is combined with Fluticasone Propionate.Vet Approved
OrphenadrineFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Fluticasone Propionate.Investigational
OsimertinibThe serum concentration of Fluticasone Propionate can be increased when it is combined with Osimertinib.Approved
OxandroloneFluticasone Propionate may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
OxaprozinThe risk or severity of adverse effects can be increased when Oxaprozin is combined with Fluticasone Propionate.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Fluticasone Propionate.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Fluticasone Propionate.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Fluticasone Propionate.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fluticasone Propionate.Approved, Illicit, Investigational
OxymetholoneFluticasone Propionate may increase the fluid retaining activities of Oxymetholone.Approved, Illicit
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Fluticasone Propionate.Approved, Investigational, Vet Approved
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Oxyphenbutazone is combined with Fluticasone Propionate.Withdrawn
PalbociclibThe serum concentration of Fluticasone Propionate can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Fluticasone Propionate.Approved
ParaldehydeFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParecoxibThe risk or severity of adverse effects can be increased when Parecoxib is combined with Fluticasone Propionate.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Paroxetine.Approved, Investigational
PazufloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Pazufloxacin.Investigational
PefloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Pefloxacin.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Fluticasone Propionate.Approved, Vet Approved
PentobarbitalThe metabolism of Fluticasone Propionate can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved
PerazineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Fluticasone Propionate.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Fluticasone Propionate.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Fluticasone Propionate.Approved
PhenobarbitalThe metabolism of Fluticasone Propionate can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Fluticasone Propionate.Approved
Phenylacetic acidThe therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Fluticasone Propionate.Approved
PhenylbutazoneThe risk or severity of adverse effects can be increased when Phenylbutazone is combined with Fluticasone Propionate.Approved, Vet Approved
PhenytoinThe metabolism of Fluticasone Propionate can be increased when combined with Phenytoin.Approved, Vet Approved
PhysostigmineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Physostigmine.Approved
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Fluticasone Propionate.Approved, Investigational
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Fluticasone Propionate.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Fluticasone Propionate.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Pipotiazine.Approved
PiretanideFluticasone Propionate may increase the hypokalemic activities of Piretanide.Experimental
PirfenidoneThe risk or severity of adverse effects can be increased when Pirfenidone is combined with Fluticasone Propionate.Investigational
PiritramideThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Piritramide.Investigational
PiroxicamThe risk or severity of adverse effects can be increased when Piroxicam is combined with Fluticasone Propionate.Approved, Investigational
PizotifenThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Pizotifen.Approved
Polyestradiol phosphateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Polyestradiol phosphate.Approved
PolythiazideFluticasone Propionate may increase the hypokalemic activities of Polythiazide.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Pomalidomide.Approved
PosaconazoleThe serum concentration of Fluticasone Propionate can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PosaconazoleThe metabolism of Fluticasone Propionate can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleFluticasone Propionate may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Fluticasone Propionate.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Fluticasone Propionate.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluticasone Propionate.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fluticasone Propionate.Approved
PrimidoneThe metabolism of Fluticasone Propionate can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Fluticasone Propionate.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Fluticasone Propionate.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Fluticasone Propionate.Approved, Vet Approved
PromestrieneThe serum concentration of Fluticasone Propionate can be increased when it is combined with Promestriene.Investigational
PromethazineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Promethazine.Approved
PropacetamolThe risk or severity of adverse effects can be increased when Propacetamol is combined with Fluticasone Propionate.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fluticasone Propionate.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Fluticasone Propionate.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Fluticasone Propionate.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Fluticasone Propionate.Approved
PrulifloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Prulifloxacin.Investigational
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Fluticasone Propionate.Investigational
PTC299The risk or severity of adverse effects can be increased when PTC299 is combined with Fluticasone Propionate.Investigational
PyridostigmineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Pyridostigmine.Approved
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Fluticasone Propionate.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Fluticasone Propionate.Approved
QuinestrolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Quinestrol.Approved
QuinethazoneFluticasone Propionate may increase the hypokalemic activities of Quinethazone.Approved
Rabies vaccineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Rabies vaccine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ramelteon.Approved, Investigational
RanolazineThe metabolism of Fluticasone Propionate can be decreased when combined with Ranolazine.Approved, Investigational
RapacuroniumRapacuronium may increase the adverse neuromuscular activities of Fluticasone Propionate.Withdrawn
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Fluticasone Propionate.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Fluticasone Propionate.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Fluticasone Propionate.Approved
ResveratrolThe risk or severity of adverse effects can be increased when Resveratrol is combined with Fluticasone Propionate.Experimental, Investigational
RifabutinThe metabolism of Fluticasone Propionate can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Fluticasone Propionate can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Fluticasone Propionate can be increased when combined with Rifapentine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Fluticasone Propionate.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ritanserin.Investigational
RitonavirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Ritonavir.Approved, Investigational
RivastigmineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Rivastigmine.Approved, Investigational
RofecoxibThe risk or severity of adverse effects can be increased when Rofecoxib is combined with Fluticasone Propionate.Investigational, Withdrawn
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Fluticasone Propionate.Vet Approved
RopiniroleFluticasone Propionate may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Fluticasone Propionate.Approved
RosoxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Rosoxacin.Approved
RotigotineFluticasone Propionate may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Fluticasone Propionate.Approved
S EquolThe serum concentration of Fluticasone Propionate can be increased when it is combined with S Equol.Investigational
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Fluticasone Propionate.Experimental
Sage 547The risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Sage 547.Investigational
SalicylamideThe risk or severity of adverse effects can be increased when Salicylamide is combined with Fluticasone Propionate.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Fluticasone Propionate.Approved, Vet Approved
SalsalateThe risk or severity of adverse effects can be increased when Salsalate is combined with Fluticasone Propionate.Approved
SaquinavirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Saquinavir.Approved, Investigational
SaquinavirThe metabolism of Fluticasone Propionate can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Fluticasone Propionate.Approved, Vet Approved
SecoisolariciresinolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Secoisolariciresinol.Investigational
SeratrodastThe risk or severity of adverse effects can be increased when Seratrodast is combined with Fluticasone Propionate.Approved, Investigational
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Fluticasone Propionate.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Fluticasone Propionate.Approved, Vet Approved
SildenafilThe metabolism of Fluticasone Propionate can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Simeprevir.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved
Sodium phenylbutyrateThe therapeutic efficacy of Sodium phenylbutyrate can be decreased when used in combination with Fluticasone Propionate.Approved
SparfloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Sparfloxacin.Approved
SRP 299The risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with SRP 299.Investigational
SRT501The risk or severity of adverse effects can be increased when SRT501 is combined with Fluticasone Propionate.Investigational
St. John's WortThe serum concentration of Fluticasone Propionate can be decreased when it is combined with St. John&#39;s Wort.Nutraceutical
StanozololFluticasone Propionate may increase the fluid retaining activities of Stanozolol.Approved, Vet Approved
StiripentolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Fluticasone Propionate.Approved, Investigational
SulfasalazineThe risk or severity of adverse effects can be increased when Sulfasalazine is combined with Fluticasone Propionate.Approved
SulfisoxazoleThe metabolism of Fluticasone Propionate can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulindacThe risk or severity of adverse effects can be increased when Sulindac is combined with Fluticasone Propionate.Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Fluticasone Propionate.Approved
SuprofenThe risk or severity of adverse effects can be increased when Suprofen is combined with Fluticasone Propionate.Approved, Withdrawn
SuvorexantFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Fluticasone Propionate can be increased when it is combined with Synthetic Conjugated Estrogens, A.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Fluticasone Propionate can be increased when it is combined with Synthetic Conjugated Estrogens, B.Approved
TacrineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Tacrine.Withdrawn
TandospironeThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Tasimelteon.Approved
TelaprevirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Telaprevir.Approved
TelithromycinThe serum concentration of Fluticasone Propionate can be increased when it is combined with Telithromycin.Approved
TelithromycinThe metabolism of Fluticasone Propionate can be decreased when combined with Telithromycin.Approved
TemafloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Temafloxacin.Withdrawn
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Fluticasone Propionate.Approved
TenoxicamThe risk or severity of adverse effects can be increased when Tenoxicam is combined with Fluticasone Propionate.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Tepoxalin is combined with Fluticasone Propionate.Vet Approved
TeriflunomideThe risk or severity of adverse effects can be increased when Teriflunomide is combined with Fluticasone Propionate.Approved
TestosteroneFluticasone Propionate may increase the fluid retaining activities of Testosterone.Approved, Investigational
TetrabenazineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Fluticasone Propionate.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Fluticasone Propionate.Investigational
TG4010The risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with TG4010.Investigational
ThalidomideFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Fluticasone Propionate.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Fluticasone Propionate.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Fluticasone Propionate.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Fluticasone Propionate.Approved
TiagabineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Tiapride.Investigational
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Tiaprofenic acid is combined with Fluticasone Propionate.Approved
TiboloneThe serum concentration of Fluticasone Propionate can be increased when it is combined with Tibolone.Approved
TiclopidineThe metabolism of Fluticasone Propionate can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Fluticasone Propionate.Vet Approved
TinoridineThe risk or severity of adverse effects can be increased when Tinoridine is combined with Fluticasone Propionate.Investigational
TipranavirThe serum concentration of Fluticasone Propionate can be increased when it is combined with Tipranavir.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Tizanidine.Approved
TocilizumabThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Fluticasone Propionate.Approved, Withdrawn
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Tolfenamic Acid is combined with Fluticasone Propionate.Approved
TolmetinThe risk or severity of adverse effects can be increased when Tolmetin is combined with Fluticasone Propionate.Approved
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Fluticasone Propionate.Approved
TorasemideFluticasone Propionate may increase the hypokalemic activities of Torasemide.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Fluticasone Propionate.Approved, Investigational
TranilastThe risk or severity of adverse effects can be increased when Tranilast is combined with Fluticasone Propionate.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Fluticasone Propionate.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Fluticasone Propionate.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Fluticasone Propionate.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Fluticasone Propionate.Approved
TrichlorfonThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Trichlorfon.Vet Approved
TrichlormethiazideFluticasone Propionate may increase the hypokalemic activities of Trichlormethiazide.Approved, Vet Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Fluticasone Propionate.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Fluticasone Propionate.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Fluticasone Propionate.Approved
Trisalicylate-cholineThe risk or severity of adverse effects can be increased when Trisalicylate-choline is combined with Fluticasone Propionate.Approved
TrovafloxacinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Trovafloxacin.Approved, Withdrawn
TubocurarineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Tubocurarine.Approved
Uc1010The risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Uc1010.Investigational
ValdecoxibThe risk or severity of adverse effects can be increased when Valdecoxib is combined with Fluticasone Propionate.Investigational, Withdrawn
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Fluticasone Propionate.Approved, Investigational
VenlafaxineThe metabolism of Fluticasone Propionate can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Fluticasone Propionate can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Vigabatrin.Approved
VoriconazoleThe serum concentration of Fluticasone Propionate can be increased when it is combined with Voriconazole.Approved, Investigational
VoriconazoleThe metabolism of Fluticasone Propionate can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Fluticasone Propionate.Approved
WarfarinFluticasone Propionate may increase the anticoagulant activities of Warfarin.Approved
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Fluticasone Propionate.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Fluticasone Propionate.Approved, Illicit, Investigational
ZaltoprofenThe risk or severity of adverse effects can be increased when Zaltoprofen is combined with Fluticasone Propionate.Approved
ZeranolThe serum concentration of Fluticasone Propionate can be increased when it is combined with Zeranol.Vet Approved
ZiconotideThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Ziconotide.Approved
ZileutonThe risk or severity of adverse effects can be increased when Zileuton is combined with Fluticasone Propionate.Approved, Investigational, Withdrawn
ZimelidineThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Fluticasone Propionate can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Fluticasone Propionate.Vet Approved
ZolpidemFluticasone Propionate may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZomepiracThe risk or severity of adverse effects can be increased when Zomepirac is combined with Fluticasone Propionate.Withdrawn
ZonisamideThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Fluticasone Propionate.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Fluticasone Propionate.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Fluticasone Propionate.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

Joseph Kaspi, Oded Arad, Michael Brand, Moty Shookrun, Simona Malka, Mohammed Alnabari, Shalom Hazan, Vlado Malesevic, “Synthesis and powder preparation of fluticasone propionate.” U.S. Patent US20060009435, issued January 12, 2006.

US20060009435
General ReferencesNot Available
External Links
ATC CodesR03AK11R03AK06R01AD08R01AD58R03BA05D07AC17
AHFS Codes
  • 52:08.08
  • 68:04.00
  • 84:06.00
PDB EntriesNot Available
FDA labelDownload (159 KB)
MSDSDownload (39 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9964
Blood Brain Barrier+0.9701
Caco-2 permeable+0.5417
P-glycoprotein substrateSubstrate0.7099
P-glycoprotein inhibitor IInhibitor0.7192
P-glycoprotein inhibitor IINon-inhibitor0.8636
Renal organic cation transporterNon-inhibitor0.8689
CYP450 2C9 substrateNon-substrate0.868
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorInhibitor0.8988
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.798
CarcinogenicityNon-carcinogens0.8901
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.3753 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.99
hERG inhibition (predictor II)Non-inhibitor0.6125
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Glaxosmithkline
  • Glaxo group ltd dba glaxosmithkline
  • Altana inc
  • G and w laboratories inc
  • Kv pharmaceutical co
  • Perrigo new york inc
  • Tolmar inc
  • Nycomed us inc
  • Taro pharmaceutical industries ltd
  • Apotex inc richmond hill
  • Hi tech pharmacal co inc
  • Roxane laboratories inc
Packagers
Dosage forms
FormRouteStrength
Aerosol, meteredRespiratory (inhalation)
PowderOral; Respiratory (inhalation)
PowderRespiratory (inhalation)
CreamTopical0.05 %
LotionTopical.5 mg/mL
Spray, meteredNasal
Spray, meteredNasal50 ug/1
Spray, meteredNasal50 mcg
Aerosol, metered; suspensionNasal50 mcg
PowderRespiratory (inhalation)100 mcg
PowderRespiratory (inhalation)250 mcg
PowderRespiratory (inhalation)50 mcg
PowderRespiratory (inhalation)500 mcg
Powder, meteredRespiratory (inhalation)100 ug/1
Powder, meteredRespiratory (inhalation)250 ug/1
Powder, meteredRespiratory (inhalation)50 ug/1
Aerosol, meteredOral; Respiratory (inhalation)125 mcg
Aerosol, meteredOral; Respiratory (inhalation)250 mcg
Aerosol, meteredOral; Respiratory (inhalation)50 mcg
Aerosol, meteredRespiratory (inhalation)110 ug/1
Aerosol, meteredRespiratory (inhalation)220 ug/1
Aerosol, meteredRespiratory (inhalation)44 ug/1
Aerosol, meteredOral; Respiratory (inhalation)25 mcg
CreamTopical.5 mg/g
OintmentTopical.05 mg/g
Spray, meteredNasal50 ug/.1g
Kit
Kit
Prices
Unit descriptionCostUnit
Fluticasone propionate powder1500.0USD g
Cutivate 0.05% Lotion 120ml Bottle454.6USD bottle
Advair Diskus 60 500-50 mcg/dose Aerosol Disp Pack328.14USD disp
Advair Diskus 60 250-50 mcg/dose Aerosol Disp Pack249.48USD disp
Flovent HFA 220 mcg/act Aerosol 12 gm Inhaler237.67USD inhaler
Cutivate 0.05% Cream 60 gm Tube217.11USD tube
Advair Diskus 60 100-50 mcg/dose Aerosol Disp Pack200.79USD disp
Advair Diskus 14 500-50 mcg/dose Aerosol Disp Pack156.64USD disp
Flovent HFA 110 mcg/act Aerosol 12 gm Inhaler153.01USD inhaler
Cutivate 0.005% Ointment 60 gm Tube128.28USD tube
Flovent HFA 44 mcg/act Aerosol 10.6 gm Inhaler114.27USD inhaler
Flovent Diskus 60 50 mcg/blist Aerosol Inhaler104.74USD inhaler
Flonase 50 mcg/act Suspension 16 gm Bottle94.59USD bottle
Fluticasone Propionate 50 mcg/act Suspension 16 gm Bottle78.28USD bottle
Cutivate 0.05% Cream 30 gm Tube62.99USD tube
Fluticasone Propionate 0.005% Ointment 60 gm Tube56.27USD tube
Fluticasone Propionate 0.05% Cream 60 gm Tube56.27USD tube
Cutivate 0.005% Ointment 30 gm Tube44.99USD tube
Fluticasone Propionate 0.005% Ointment 30 gm Tube35.67USD tube
Fluticasone Propionate 0.05% Cream 30 gm Tube35.67USD tube
Cutivate 0.005% Ointment 15 gm Tube32.99USD tube
Cutivate 0.05% Cream 15 gm Tube32.99USD tube
Advair hfa 230-21 mcg inhaler25.04USD g
Fluticasone Propionate 0.005% Ointment 15 gm Tube23.14USD tube
Fluticasone Propionate 0.05% Cream 15 gm Tube23.14USD tube
Advair hfa 115-21 mcg inhaler18.13USD g
Flovent hfa 220 mcg inhaler15.54USD g
Advair hfa 45-21 mcg inhaler14.59USD g
Flovent hfa 110 mcg inhaler12.26USD g
Flovent hfa 44 mcg inhaler10.99USD g
Flonase 0.05% nasal spray5.68USD g
Advair 500-50 diskus5.26USD each
Advair 250-50 diskus4.0USD each
Cutivate 0.05% cream3.48USD g
Advair 100-50 diskus3.22USD each
Flovent 250 mcg diskus2.45USD each
Flovent 100 mcg diskus1.83USD each
Flovent 50 mcg diskus1.74USD each
Flovent Diskus 500 mcg/dose Metered Inhalation Powder1.55USD dose
Flovent Diskus 250 mcg/dose Metered Inhalation Powder0.77USD dose
Flovent Hfa 250 mcg/dose Metered Dose Aerosol0.77USD dose
Flovent Hfa 125 mcg/dose Metered Dose Aerosol0.39USD dose
Flovent Hfa 50 mcg/dose Metered Dose Aerosol0.22USD dose
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2125667 No2000-03-132012-12-04Canada
CA2317999 No2004-11-092020-09-11Canada
US5873360 Yes1996-08-232016-08-23Us
US6161724 Yes1998-07-162018-07-16Us
US6170717 Yes1998-06-232018-06-23Us
US6315173 Yes1998-06-232018-06-23Us
US6431168 Yes1998-12-082018-12-08Us
US6435372 Yes1998-07-162018-07-16Us
US6510969 Yes1998-06-232018-06-23Us
US6743413 Yes2001-12-012021-12-01Us
US6938796 Yes1998-07-162018-07-16Us
US6966467 Yes1998-06-232018-06-23Us
US6997349 Yes1998-07-162018-07-16Us
US7107986 Yes1998-12-082018-12-08Us
US7143908 Yes1998-07-162018-07-16Us
US7300669 No1999-10-202019-10-20Us
US7350676 Yes1999-02-242019-02-24Us
US7500444 Yes2006-08-262026-08-26Us
US7832351 Yes2003-12-192023-12-19Us
US8163723 No2003-08-292023-08-29Us
US8168620 No2006-02-242026-02-24Us
US9259428 No2003-06-132023-06-13Us
USRE40045 No1993-09-072010-09-07Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point272-273 °CNot Available
water solubility0.51 mg/L (insoluble)Not Available
logP3.4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0114 mg/mLALOGPS
logP3.69ALOGPS
logP3.72ChemAxon
logS-4.6ALOGPS
pKa (Strongest Acidic)13.56ChemAxon
pKa (Strongest Basic)-3.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area80.67 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity121.65 m3·mol-1ChemAxon
Polarizability49.26 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as steroid esters. These are compounds containing a steroid moiety which bears a carboxylic acid ester group.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassSteroid esters
Direct ParentSteroid esters
Alternative Parents
Substituents
  • Steroid ester
  • Androgen-skeleton
  • Androstane-skeleton
  • 11-hydroxysteroid
  • 11-beta-hydroxysteroid
  • Oxosteroid
  • Hydroxysteroid
  • Halo-steroid
  • 6-halo-steroid
  • 9-halo-steroid
  • 3-oxosteroid
  • 3-oxo-delta-1,4-steroid
  • Delta-1,4-steroid
  • Cyclic alcohol
  • Cyclic ketone
  • Thiocarboxylic acid ester
  • Secondary alcohol
  • Ketone
  • Halohydrin
  • Fluorohydrin
  • Carboxylic acid ester
  • Sulfenyl compound
  • Thioether
  • Thiocarboxylic acid or derivatives
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Halomethane
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organofluoride
  • Organohalogen compound
  • Carbonyl group
  • Alkyl halide
  • Alkyl fluoride
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon grow...
Gene Name:
NR3C1
Uniprot ID:
P04150
Molecular Weight:
85658.57 Da
References
  1. Andersson O, Cassel TN, Gronneberg R, Bronnegard M, Stierna P, Nord M: In vivo modulation of glucocorticoid receptor mRNA by inhaled fluticasone propionate in bronchial mucosa and blood lymphocytes in subjects with mild asthma. J Allergy Clin Immunol. 1999 Apr;103(4):595-600. [PubMed:10200007 ]
  2. Lumry WR: A review of the preclinical and clinical data of newer intranasal steroids used in the treatment of allergic rhinitis. J Allergy Clin Immunol. 1999 Oct;104(4 Pt 1):S150-8. [PubMed:10518812 ]
  3. Zhang X, Moilanen E, Kankaanranta H: Beclomethasone, budesonide and fluticasone propionate inhibit human neutrophil apoptosis. Eur J Pharmacol. 2001 Nov 23;431(3):365-71. [PubMed:11730731 ]
  4. Hogger P, Rohdewald P: Binding kinetics of fluticasone propionate to the human glucocorticoid receptor. Steroids. 1994 Oct;59(10):597-602. [PubMed:7878687 ]
  5. Johnson M: Fluticasone propionate: safety profile. Cutis. 1996 Feb;57(2 Suppl):10-2. [PubMed:8646863 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.Isoform 4: Increases mitochondrial ...
Gene Name:
PGR
Uniprot ID:
P06401
Molecular Weight:
98979.96 Da
References
  1. Issar M, Sahasranaman S, Buchwald P, Hochhaus G: Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids. Eur Respir J. 2006 Mar;27(3):511-6. [PubMed:16507850 ]
  2. Austin RJ, Maschera B, Walker A, Fairbairn L, Meldrum E, Farrow SN, Uings IJ: Mometasone furoate is a less specific glucocorticoid than fluticasone propionate. Eur Respir J. 2002 Dec;20(6):1386-92. [PubMed:12503693 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Phospholipase a2 activity
Specific Function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Gene Name:
PLA2G4A
Uniprot ID:
P47712
Molecular Weight:
85238.2 Da
References
  1. Sano A, Munoz NM, Sano H, Choi J, Zhu X, Jacobs B, Leff AR: Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. Am J Respir Crit Care Med. 1999 Jun;159(6):1903-9. [PubMed:10351938 ]
  2. Myo S, Zhu X, Myou S, Meliton AY, Liu J, Boetticher E, Lambertino AT, Xu C, Munoz NM, Leff AR: Additive blockade of beta 2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate. Eur Respir J. 2004 Apr;23(4):511-7. [PubMed:15083746 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Zinc ion binding
Specific Function:
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Gene Name:
NR3C2
Uniprot ID:
P08235
Molecular Weight:
107066.575 Da
References
  1. Austin RJ, Maschera B, Walker A, Fairbairn L, Meldrum E, Farrow SN, Uings IJ: Mometasone furoate is a less specific glucocorticoid than fluticasone propionate. Eur Respir J. 2002 Dec;20(6):1386-92. [PubMed:12503693 ]
  2. Issar M, Sahasranaman S, Buchwald P, Hochhaus G: Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids. Eur Respir J. 2006 Mar;27(3):511-6. [PubMed:16507850 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Pearce RE, Leeder JS, Kearns GL: Biotransformation of fluticasone: in vitro characterization. Drug Metab Dispos. 2006 Jun;34(6):1035-40. Epub 2006 Mar 24. [PubMed:16565171 ]
  2. Murai T, Reilly CA, Ward RM, Yost GS: The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme. Chem Res Toxicol. 2010 Aug 16;23(8):1356-64. doi: 10.1021/tx100124k. [PubMed:20707410 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Pearce RE, Leeder JS, Kearns GL: Biotransformation of fluticasone: in vitro characterization. Drug Metab Dispos. 2006 Jun;34(6):1035-40. Epub 2006 Mar 24. [PubMed:16565171 ]
  2. Murai T, Reilly CA, Ward RM, Yost GS: The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme. Chem Res Toxicol. 2010 Aug 16;23(8):1356-64. doi: 10.1021/tx100124k. [PubMed:20707410 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Pearce RE, Leeder JS, Kearns GL: Biotransformation of fluticasone: in vitro characterization. Drug Metab Dispos. 2006 Jun;34(6):1035-40. Epub 2006 Mar 24. [PubMed:16565171 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Steroid binding
Specific Function:
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name:
SERPINA6
Uniprot ID:
P08185
Molecular Weight:
45140.49 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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Drug created on June 13, 2005 07:24 / Updated on December 07, 2016 03:54