Potassium sulfate

Identification

Name
Potassium sulfate
Accession Number
DB14499  (DBSALT001465)
Type
Small Molecule
Groups
Approved, Investigational
Description
Not Available
Structure
Thumb
Synonyms
  • Dipotassium sulfate
  • Potasio sulfato
  • Potassium (as sulfate)
  • Potassium sulphate
  • Sulfato potasio
  • Sulfuric acid, dipotassium salt
External IDs
E-515(I) / Ins no.515(I) / Ins-515(I)
Active Moieties
NameKindUNIICASInChI Key
Potassium cationionic295O53K15224203-36-9NPYPAHLBTDXSSS-UHFFFAOYSA-N
Sulfate ionionic7IS9N8KPMG14808-79-8QAOWNCQODCNURD-UHFFFAOYSA-L
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
ColPrep KitPotassium sulfate (3.13 g/22.7g) + Magnesium sulfate (1.6 g/22.7g) + Sodium sulfate decahydrate (17.5 g/22.7g)Powder, for solutionOralKvk Tech,Inc2016-12-27Not applicableUs
SuclearPotassium sulfate (3.13 g/1mL) + Magnesium sulfate (1.6 g/1mL) + Polyethylene glycol (210 g/2L) + Potassium Chloride (0.74 g/2L) + Sodium Chloride (5.60 g/2L) + Sodium bicarbonate (2.86 g/2L) + Sodium sulfate decahydrate (17.5 g/1mL)KitOralBraintree Laboratories2013-01-182016-08-31Us
SUPREP Bowel PrepPotassium sulfate (3.13 g/1mL) + Magnesium sulfate (1.6 g/1mL) + Sodium sulfate decahydrate (17.5 g/1mL)Solution, concentrateOralBraintree Laboratories2010-08-05Not applicableUs
Categories
UNII
1K573LC5TV
CAS number
7778-80-5
Weight
Average: 174.259
Monoisotopic: 173.8791429
Chemical Formula
K2O4S
InChI Key
OTYBMLCTZGSZBG-UHFFFAOYSA-L
InChI
InChI=1S/2K.H2O4S/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2
IUPAC Name
dipotassium sulfate
SMILES
[K+].[K+].[O-]S([O-])(=O)=O

Pharmacology

Indication

Potassium is used to regulate hypokalemia as a primary condition or secondary to other medical conditions.

Associated Therapies
Pharmacodynamics
Not Available
Mechanism of action

Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential—a "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.

TargetActionsOrganism
USodium/potassium-transporting ATPase subunit alpha-1Not AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination

Mostly urine but also skin and feces.

Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
AcarboseAcarbose may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
AcebutololPotassium sulfate may increase the hyperkalemic activities of Acebutolol.
AceclofenacAceclofenac may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
AcetaminophenAcetaminophen may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Potassium sulfate.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
AclidiniumThe therapeutic efficacy of Potassium sulfate can be decreased when used in combination with Aclidinium.
AcrivastineAcrivastine may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
Food Interactions
Not Available

References

General References
Not Available
External Links
KEGG Compound
C13192
ChemSpider
22915
ChEBI
32036
ChEMBL
CHEMBL2021424
Wikipedia
Potassium_sulfate

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Powder, for solutionOral
KitOral
Solution, concentrateOral
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6946149No2003-03-072023-03-07Us

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.84ChemAxon
pKa (Strongest Acidic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area80.26 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.53 m3·mol-1ChemAxon
Polarizability5.81 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as alkali metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal oxoanionic compounds
Sub Class
Alkali metal sulfates
Direct Parent
Alkali metal sulfates
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Alkali metal sulfate / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
potassium salt (CHEBI:32036)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Steroid hormone binding
Specific Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates th...
Gene Name
ATP1A1
Uniprot ID
P05023
Uniprot Name
Sodium/potassium-transporting ATPase subunit alpha-1
Molecular Weight
112895.01 Da
References
  1. Silva E, Gomes P, Soares-da-Silva P: Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing. J Membr Biol. 2006;212(3):163-75. Epub 2007 Feb 28. [PubMed:17334838]
  2. Li C, Geering K, Horisberger JD: The third sodium binding site of Na,K-ATPase is functionally linked to acidic pH-activated inward current. J Membr Biol. 2006;213(1):1-9. Epub 2007 Mar 8. [PubMed:17347782]
  3. Stanely Mainzen Prince P, Karthick M: Preventive effect of rutin on lipids, lipoproteins, and ATPases in normal and isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol. 2007;21(1):1-6. [PubMed:17366541]
  4. Simon WA, Herrmann M, Klein T, Shin JM, Huber R, Senn-Bilfinger J, Postius S: Soraprazan: setting new standards in inhibition of gastric acid secretion. J Pharmacol Exp Ther. 2007 Jun;321(3):866-74. Epub 2007 Mar 16. [PubMed:17369284]
  5. Iannello S, Milazzo P, Belfiore F: Animal and human tissue Na,K-ATPase in normal and insulin-resistant states: regulation, behaviour and interpretative hypothesis on NEFA effects. Obes Rev. 2007 May;8(3):231-51. [PubMed:17444965]

Drug created on July 11, 2018 10:29 / Updated on November 05, 2018 17:50