Identification

Name
Nimodipine
Accession Number
DB00393  (APRD00612)
Type
Small Molecule
Groups
Approved, Investigational
Description

Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Compared to other calcium channel blocking agents, nimodipine exhibits greater effects on cerebral circulation than on peripheral circulation. Nimodipine is used to as an adjunct to improve the neurologic outcome following subarachnoid hemorrhage from ruptured intracranial aneurysm.

Structure
Thumb
Synonyms
  • 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-methoxyethyl ester 5-isopropyl ester
  • isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
  • isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
  • Nimodipino
  • Nimodipinum
External IDs
BAY E 9736 / BAY-E-9736
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
NimotopTablet30 mgOralBayer2009-07-24Not applicableCanada
Nimotop - Cap 30mgCapsule30 mgOralBayer1989-12-312009-08-06Canada
Nimotop Cap 30mgCapsule30 mgOralMiles Inc. Pharmaceutical Division1989-12-311996-10-02Canada
Nimotop I.V.-0.2mg/mlLiquid.2 mgIntravenousBayer1996-10-082000-09-19Canada
Nimotop IV 0.2mg/mlLiquid0.2 mgIntravenousMiles Inc. Pharmaceutical Division1992-12-312000-08-01Canada
NymalizeSolution60 mg/20mLOralArbor Pharmaceuticals2013-06-03Not applicableUs
NymalizeSolution30 mg/10mLOralArbor Pharmaceuticals2017-04-06Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
NimodipineCapsule, liquid filled30 mg/1OralHeritage2008-03-21Not applicableUs
NimodipineCapsule, liquid filled30 mg/1OralMajor2015-01-01Not applicableUs
NimodipineCapsule, liquid filled30 mg/1OralAscend Laboratories, LLC2015-01-01Not applicableUs
NimodipineCapsule30 mg/1OralCaraco Pharmaceutical Laboratories, Ltd.2007-06-28Not applicableUs
NimodipineCapsule, liquid filled30 mg/1OralHeritage2017-11-07Not applicableUs
NimodipineCapsule, liquid filled30 mg/1OralAmerincan Health Packaging2015-02-15Not applicableUs
NimodipineCapsule30 mg/1OralANI Pharmaceuticals, Inc.2015-11-01Not applicableUs
NimodipineCapsule30 mg/1OralCardinal Health2007-06-28Not applicableUs
NimodipineCapsule, liquid filled30 mg/1OralBionpharma Inc.2017-11-21Not applicableUs
NimodipineCapsule, liquid filled30 mg/1OralCardinal Health2008-03-21Not applicableUs
International/Other Brands
Periplum
Categories
UNII
57WA9QZ5WH
CAS number
66085-59-4
Weight
Average: 418.4403
Monoisotopic: 418.174001196
Chemical Formula
C21H26N2O7
InChI Key
UIAGMCDKSXEBJQ-UHFFFAOYSA-N
InChI
InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
IUPAC Name
3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
SMILES
COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)C

Pharmacology

Indication

For use as an adjunct to improve neurologic outcome following subarachnoid hemorrhage (SAH) from ruptured intracranial berry aneurysms by reducing the incidence and severity of ischemic deficits.

Structured Indications
Pharmacodynamics

Nimodipine belongs to the class of pharmacological agents known as calcium channel blockers. Nimodipine is indicated for the improvement of neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured congenital aneurysms who are in good neurological condition post-ictus (e.g., Hunt and Hess Grades I-III). The contractile processes of smooth muscle cells are dependent upon calcium ions, which enter these cells during depolarization as slow ionic transmembrane currents. Nimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscle. In animal experiments, nimodipine had a greater effect on cerebral arteries than on arteries elsewhere in the body perhaps because it is highly lipophilic, allowing it to cross the blood brain barrier.

Mechanism of action

Although the precise mechanism of action is not known, nimodipine blocks intracellular influx of calcium through voltage-dependent and receptor-operated slow calcium channels across the membranes of myocardial, vascular smooth muscle, and neuronal cells. Nimodipine binds specifically to L-type voltage-gated calcium channels. The inhibition of calcium ion transfer results in the inhibition of vascular smooth muscle contraction. Evidence suggests that the dilation of small cerebral resistance vessels, with a resultant increase in collateral circulation, and/or a direct effect involving the prevention of calcium overload in neurons may be responsible for nimodipine's clinical effect in patients with subarachnoid hemorrhage.

TargetActionsOrganism
AVoltage-dependent L-type calcium channel subunit alpha-1C
inhibitor
Human
AVoltage-dependent L-type calcium channel subunit alpha-1D
inhibitor
Human
AVoltage-dependent L-type calcium channel subunit alpha-1F
inhibitor
Human
AVoltage-dependent L-type calcium channel subunit alpha-1S
inhibitor
Human
AVoltage-dependent L-type calcium channel subunit beta-1
inhibitor
Human
AVoltage-dependent L-type calcium channel subunit beta-2
inhibitor
Human
AVoltage-dependent L-type calcium channel subunit beta-3
inhibitor
Human
AVoltage-dependent L-type calcium channel subunit beta-4
inhibitor
Human
UMineralocorticoid receptor
antagonist
Human
UAryl hydrocarbon receptor
agonist
Human
Absorption

In humans, nimodipine is rapidly absorbed after oral administration, and peak concentrations are generally attained within one hour. Bioavailability is 100% following intravenous administration and 3-30% following oral administration due to extensive first-pass metabolism.

Volume of distribution
Not Available
Protein binding

95% bound to plasma protein

Metabolism

Hepatic metabolism via CYP 3A4.

Route of elimination

Nimodipine is eliminated almost exclusively in the form of metabolites and less than 1% is recovered in the urine as unchanged drug. Numerous metabolites, all of which are either inactive or considerably less active than the parent compound, have been identified.

Half life

1.7-9 hours

Clearance
Not Available
Toxicity

Symptoms of overdosage would be expected to be related to cardiovascular effects such as excessive peripheral vasodilation with marked systemic hypotension.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Nimodipine Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2-HYDROXY-1,4-NAPHTHOQUINONEThe therapeutic efficacy of 2-HYDROXY-1,4-NAPHTHOQUINONE can be increased when used in combination with Nimodipine.Experimental
2-mercaptobenzothiazoleThe therapeutic efficacy of 2-mercaptobenzothiazole can be increased when used in combination with Nimodipine.Vet Approved
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Nimodipine.Experimental
AcebutololNimodipine may increase the hypotensive activities of Acebutolol.Approved, Investigational
AcemetacinThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Acemetacin.Approved, Experimental, Investigational
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Nimodipine.Approved
AlfuzosinAlfuzosin may increase the hypotensive activities of Nimodipine.Approved, Investigational
AliskirenNimodipine may increase the hypotensive activities of Aliskiren.Approved, Investigational
AlprenololNimodipine may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AmbrisentanNimodipine may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmifostineNimodipine may increase the hypotensive activities of Amifostine.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Nimodipine is combined with Amiloride.Approved
AmiodaroneThe serum concentration of Nimodipine can be increased when it is combined with Amiodarone.Approved, Investigational
AmlodipineAmlodipine may increase the hypotensive activities of Nimodipine.Approved
AmobarbitalThe metabolism of Nimodipine can be increased when combined with Amobarbital.Approved, Illicit
AmorolfineThe therapeutic efficacy of Amorolfine can be increased when used in combination with Nimodipine.Approved, Investigational
AmphetamineAmphetamine may increase the hypotensive activities of Nimodipine.Approved, Illicit, Investigational
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Nimodipine.Approved, Investigational
Amyl NitriteThe risk or severity of adverse effects can be increased when Nimodipine is combined with Amyl Nitrite.Approved
AnidulafunginThe therapeutic efficacy of Anidulafungin can be increased when used in combination with Nimodipine.Approved, Investigational
ApalutamideThe serum concentration of Nimodipine can be decreased when it is combined with Apalutamide.Approved, Investigational
ApomorphineThe risk or severity of adverse effects can be increased when Apomorphine is combined with Nimodipine.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Apraclonidine.Approved
AprepitantThe serum concentration of Nimodipine can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleAripiprazole may increase the hypotensive activities of Nimodipine.Approved, Investigational
ArotinololThe risk or severity of hypotension, conduction block, and bradycardia can be increased when Arotinolol is combined with Nimodipine.Investigational
Arsenic trioxideThe risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Nimodipine.Approved, Investigational
ArtemetherThe therapeutic efficacy of Artemether can be increased when used in combination with Nimodipine.Approved
AtazanavirThe serum concentration of Nimodipine can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololAtenolol may increase the hypotensive activities of Nimodipine.Approved
AtomoxetineThe serum concentration of Nimodipine can be increased when it is combined with Atomoxetine.Approved
AvanafilAvanafil may increase the antihypertensive activities of Nimodipine.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Nimodipine is combined with Azilsartan medoxomil.Approved, Investigational
Bafilomycin A1The therapeutic efficacy of Bafilomycin A1 can be increased when used in combination with Nimodipine.Experimental
BarbexacloneThe metabolism of Nimodipine can be increased when combined with Barbexaclone.Experimental
BarbitalThe metabolism of Nimodipine can be increased when combined with Barbital.Illicit
BarnidipineNimodipine may increase the antihypertensive activities of Barnidipine.Approved
BenazeprilNimodipine may increase the hypotensive activities of Benazepril.Approved, Investigational
BendroflumethiazideNimodipine may increase the hypotensive activities of Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the hypotensive activities of Nimodipine.Withdrawn
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be increased when used in combination with Nimodipine.Approved, Investigational
BepridilNimodipine may increase the hypotensive activities of Bepridil.Approved, Withdrawn
BetaxololBetaxolol may increase the hypotensive activities of Nimodipine.Approved, Investigational
BethanidineBethanidine may increase the hypotensive activities of Nimodipine.Approved
BietaserpineBietaserpine may increase the hypotensive activities of Nimodipine.Experimental
BifonazoleThe therapeutic efficacy of Bifonazole can be increased when used in combination with Nimodipine.Approved, Investigational
BimatoprostNimodipine may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BisoprololNimodipine may increase the hypotensive activities of Bisoprolol.Approved
BoceprevirThe serum concentration of Nimodipine can be increased when it is combined with Boceprevir.Approved, Withdrawn
BortezomibThe serum concentration of Nimodipine can be increased when it is combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Nimodipine can be decreased when it is combined with Bosentan.Approved, Investigational
BQ-123Nimodipine may increase the hypotensive activities of BQ-123.Investigational
Brefeldin AThe therapeutic efficacy of Brefeldin A can be increased when used in combination with Nimodipine.Experimental
BretyliumNimodipine may increase the hypotensive activities of Bretylium.Approved
BrimonidineBrimonidine may increase the antihypertensive activities of Nimodipine.Approved
BrofaromineBrofaromine may increase the hypotensive activities of Nimodipine.Experimental
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Nimodipine.Approved, Investigational
BucindololThe risk or severity of hypotension can be increased when Bucindolol is combined with Nimodipine.Investigational
BumetanideThe risk or severity of adverse effects can be increased when Nimodipine is combined with Bumetanide.Approved
BunazosinThe risk or severity of hypotension can be increased when Bunazosin is combined with Nimodipine.Investigational
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nimodipine.Approved, Investigational
BupranololNimodipine may increase the hypotensive activities of Bupranolol.Approved
ButenafineThe therapeutic efficacy of Butenafine can be increased when used in combination with Nimodipine.Approved
ButoconazoleThe therapeutic efficacy of Butoconazole can be increased when used in combination with Nimodipine.Approved
CadralazineCadralazine may increase the hypotensive activities of Nimodipine.Experimental
CafedrineNimodipine may increase the hypotensive activities of Cafedrine.Investigational
Calcium AcetateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium Acetate.Approved, Investigational
Calcium CarbonateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium Carbonate.Approved, Investigational
Calcium ChlorideThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium Chloride.Approved
Calcium CitrateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium Citrate.Approved
Calcium glubionateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
Calcium lactateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium lactate.Approved, Experimental, Investigational, Vet Approved
Calcium lactate gluconateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium lactate gluconate.Experimental
Calcium levulinateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium levulinate.Approved, Experimental
Calcium pangamateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium pangamate.Experimental
Calcium PhosphateThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium Phosphate.Approved
CanagliflozinThe risk or severity of adverse effects can be increased when Nimodipine is combined with Canagliflozin.Approved
CandesartanNimodipine may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilNimodipine may increase the hypotensive activities of Candesartan cilexetil.Approved
CandicidinThe therapeutic efficacy of Candicidin can be increased when used in combination with Nimodipine.Withdrawn
CandoxatrilNimodipine may increase the hypotensive activities of Candoxatril.Experimental
Capric acidThe therapeutic efficacy of Capric acid can be increased when used in combination with Nimodipine.Experimental
CaptoprilNimodipine may increase the hypotensive activities of Captopril.Approved
CarbamazepineThe metabolism of Nimodipine can be increased when combined with Carbamazepine.Approved, Investigational
CarbetocinThe risk or severity of adverse effects can be increased when Carbetocin is combined with Nimodipine.Approved, Investigational
CaroxazoneCaroxazone may increase the hypotensive activities of Nimodipine.Withdrawn
CarteololNimodipine may increase the hypotensive activities of Carteolol.Approved
CarvedilolNimodipine may increase the hypotensive activities of Carvedilol.Approved, Investigational
CaseinThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Casein.Approved
CaspofunginThe therapeutic efficacy of Caspofungin can be increased when used in combination with Nimodipine.Approved
CeliprololNimodipine may increase the hypotensive activities of Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Nimodipine can be increased when it is combined with Ceritinib.Approved
CeruleninThe therapeutic efficacy of Cerulenin can be increased when used in combination with Nimodipine.Approved
ChlorothiazideNimodipine may increase the hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChloroxineThe therapeutic efficacy of Chloroxine can be increased when used in combination with Nimodipine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Nimodipine.Approved, Investigational, Vet Approved
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Nimodipine.Approved
CicletanineNimodipine may increase the hypotensive activities of Cicletanine.Investigational
CiclopiroxThe therapeutic efficacy of Ciclopirox can be increased when used in combination with Nimodipine.Approved, Investigational
CilazaprilNimodipine may increase the hypotensive activities of Cilazapril.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Cilnidipine is combined with Nimodipine.Approved, Investigational
CimetidineThe serum concentration of Nimodipine can be increased when it is combined with Cimetidine.Approved, Investigational
ClarithromycinThe serum concentration of Nimodipine can be increased when it is combined with Clarithromycin.Approved
ClemastineThe serum concentration of Nimodipine can be increased when it is combined with Clemastine.Approved, Investigational
ClevidipineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Clevidipine.Approved, Investigational
ClofarabineThe risk or severity of adverse effects can be increased when Clofarabine is combined with Nimodipine.Approved, Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Nimodipine.Approved, Investigational, Vet Approved
ClonidineClonidine may increase the hypotensive activities of Nimodipine.Approved
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Nimodipine.Approved
CloranololNimodipine may increase the hypotensive activities of Cloranolol.Experimental
ClotrimazoleThe serum concentration of Nimodipine can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Nimodipine.Approved
CobicistatThe serum concentration of Nimodipine can be increased when it is combined with Cobicistat.Approved
ConivaptanThe serum concentration of Nimodipine can be increased when it is combined with Conivaptan.Approved, Investigational
CordycepinThe therapeutic efficacy of Cordycepin can be increased when used in combination with Nimodipine.Investigational
CrizotinibThe serum concentration of Nimodipine can be increased when it is combined with Crizotinib.Approved
CryptenamineNimodipine may increase the hypotensive activities of Cryptenamine.Approved
CyclopenthiazideNimodipine may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclosporineThe serum concentration of Nimodipine can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
CyclothiazideNimodipine may increase the hypotensive activities of Cyclothiazide.Approved
DabrafenibThe serum concentration of Nimodipine can be decreased when it is combined with Dabrafenib.Approved, Investigational
DapagliflozinThe risk or severity of adverse effects can be increased when Nimodipine is combined with Dapagliflozin.Approved
DarunavirThe serum concentration of Nimodipine can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Nimodipine can be increased when it is combined with Dasatinib.Approved, Investigational
DebrisoquinDebrisoquin may increase the hypotensive activities of Nimodipine.Approved, Investigational
DeferasiroxThe serum concentration of Nimodipine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelaprilNimodipine may increase the hypotensive activities of Delapril.Experimental
DelavirdineThe serum concentration of Nimodipine can be increased when it is combined with Delavirdine.Approved
DeserpidineNimodipine may increase the hypotensive activities of Deserpidine.Approved
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Nimodipine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Dexmedetomidine.Approved, Vet Approved
DiazoxideDiazoxide may increase the hypotensive activities of Nimodipine.Approved
DichloropheneThe therapeutic efficacy of Dichlorophene can be increased when used in combination with Nimodipine.Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Nimodipine is combined with Diclofenamide.Approved, Investigational
DiethylnorspermineNimodipine may increase the hypotensive activities of Diethylnorspermine.Investigational
DihydralazineDihydralazine may increase the hypotensive activities of Nimodipine.Approved, Investigational
DihydroergotamineThe serum concentration of Nimodipine can be increased when it is combined with Dihydroergotamine.Approved, Investigational
DiltiazemThe serum concentration of Nimodipine can be increased when it is combined with Diltiazem.Approved, Investigational
DinutuximabThe risk or severity of adverse effects can be increased when Nimodipine is combined with Dinutuximab.Approved, Investigational
DipyridamoleThe risk or severity of adverse effects can be increased when Nimodipine is combined with Dipyridamole.Approved
DorzolamideNimodipine may increase the hypotensive activities of Dorzolamide.Approved
DoxazosinDoxazosin may increase the hypotensive activities of Nimodipine.Approved
DoxycyclineThe serum concentration of Nimodipine can be increased when it is combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe serum concentration of Nimodipine can be increased when it is combined with Dronedarone.Approved
DuloxetineNimodipine may increase the orthostatic hypotensive activities of Duloxetine.Approved
EconazoleThe therapeutic efficacy of Econazole can be increased when used in combination with Nimodipine.Approved
EfavirenzThe serum concentration of Nimodipine can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe therapeutic efficacy of Efinaconazole can be increased when used in combination with Nimodipine.Approved
EfonidipineNimodipine may increase the hypotensive activities of Efonidipine.Approved, Investigational
EmpagliflozinThe risk or severity of adverse effects can be increased when Nimodipine is combined with Empagliflozin.Approved
EnalaprilNimodipine may increase the hypotensive activities of Enalapril.Approved, Vet Approved
EnalaprilatNimodipine may increase the hypotensive activities of Enalaprilat.Approved
EndralazineEndralazine may increase the hypotensive activities of Nimodipine.Experimental
EnzalutamideThe serum concentration of Nimodipine can be decreased when it is combined with Enzalutamide.Approved
EpanololNimodipine may increase the hypotensive activities of Epanolol.Experimental
EplerenoneThe risk or severity of adverse effects can be increased when Nimodipine is combined with Eplerenone.Approved
EpoprostenolNimodipine may increase the hypotensive activities of Epoprostenol.Approved
EprosartanNimodipine may increase the hypotensive activities of Eprosartan.Approved
ErythromycinThe serum concentration of Nimodipine can be increased when it is combined with Erythromycin.Approved, Investigational, Vet Approved
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Nimodipine.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Nimodipine is combined with Etacrynic acid.Approved, Investigational
FelodipineNimodipine may increase the hypotensive activities of Felodipine.Approved, Investigational
FenoldopamNimodipine may increase the hypotensive activities of Fenoldopam.Approved
FenticonazoleThe therapeutic efficacy of Fenticonazole can be increased when used in combination with Nimodipine.Experimental
Ferulic acidNimodipine may increase the hypotensive activities of Ferulic acid.Experimental
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Nimodipine.Approved, Investigational
FluconazoleThe serum concentration of Nimodipine can be increased when it is combined with Fluconazole.Approved, Investigational
FlucytosineThe therapeutic efficacy of Flucytosine can be increased when used in combination with Nimodipine.Approved, Investigational
FluoxetineThe serum concentration of Nimodipine can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlutrimazoleThe therapeutic efficacy of Flutrimazole can be increased when used in combination with Nimodipine.Experimental
FluvoxamineThe serum concentration of Nimodipine can be increased when it is combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe serum concentration of Nimodipine can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Nimodipine can be increased when it is combined with Fosaprepitant.Approved
FosinoprilNimodipine may increase the hypotensive activities of Fosinopril.Approved
FosphenytoinThe serum concentration of Nimodipine can be decreased when it is combined with Fosphenytoin.Approved, Investigational
FurazolidoneFurazolidone may increase the hypotensive activities of Nimodipine.Approved, Investigational, Vet Approved
FurosemideThe risk or severity of adverse effects can be increased when Nimodipine is combined with Furosemide.Approved, Vet Approved
Fusidic AcidThe serum concentration of Nimodipine can be increased when it is combined with Fusidic Acid.Approved, Investigational
GlyphosateThe therapeutic efficacy of Glyphosate can be increased when used in combination with Nimodipine.Experimental
GriseofulvinThe therapeutic efficacy of Griseofulvin can be increased when used in combination with Nimodipine.Approved, Investigational, Vet Approved
GuanabenzNimodipine may increase the hypotensive activities of Guanabenz.Approved, Investigational
GuanadrelGuanadrel may increase the hypotensive activities of Nimodipine.Approved
GuanazodineNimodipine may increase the hypotensive activities of Guanazodine.Experimental
GuanethidineNimodipine may increase the hypotensive activities of Guanethidine.Approved
GuanfacineGuanfacine may increase the hypotensive activities of Nimodipine.Approved, Investigational
GuanoclorNimodipine may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzNimodipine may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanNimodipine may increase the hypotensive activities of Guanoxan.Experimental
HachimycinThe therapeutic efficacy of Hachimycin can be increased when used in combination with Nimodipine.Experimental
HaloproginThe therapeutic efficacy of Haloprogin can be increased when used in combination with Nimodipine.Approved, Withdrawn
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Nimodipine.Approved, Vet Approved
HarmalineHarmaline may increase the hypotensive activities of Nimodipine.Experimental
HexamethoniumNimodipine may increase the hypotensive activities of Hexamethonium.Experimental
HexetidineThe therapeutic efficacy of Hexetidine can be increased when used in combination with Nimodipine.Approved, Investigational
HexobarbitalThe metabolism of Nimodipine can be increased when combined with Hexobarbital.Approved
HydracarbazineHydracarbazine may increase the hypotensive activities of Nimodipine.Experimental
HydralazineHydralazine may increase the hypotensive activities of Nimodipine.Approved
HydrochlorothiazideNimodipine may increase the hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydroflumethiazideNimodipine may increase the hypotensive activities of Hydroflumethiazide.Approved, Investigational
IdelalisibThe serum concentration of Nimodipine can be increased when it is combined with Idelalisib.Approved
IloprostThe risk or severity of adverse effects can be increased when Iloprost is combined with Nimodipine.Approved, Investigational
ImatinibThe serum concentration of Nimodipine can be increased when it is combined with Imatinib.Approved
ImidaprilNimodipine may increase the hypotensive activities of Imidapril.Investigational
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Nimodipine.Approved
IndapamideNimodipine may increase the hypotensive activities of Indapamide.Approved
IndenololNimodipine may increase the hypotensive activities of Indenolol.Withdrawn
IndinavirThe serum concentration of Nimodipine can be increased when it is combined with Indinavir.Approved
IndoraminIndoramin may increase the hypotensive activities of Nimodipine.Withdrawn
IproclozideIproclozide may increase the hypotensive activities of Nimodipine.Withdrawn
IproniazidIproniazid may increase the hypotensive activities of Nimodipine.Withdrawn
IrbesartanNimodipine may increase the hypotensive activities of Irbesartan.Approved, Investigational
IsavuconazoniumThe serum concentration of Nimodipine can be increased when it is combined with Isavuconazonium.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Nimodipine.Approved
IsoconazoleThe therapeutic efficacy of Isoconazole can be increased when used in combination with Nimodipine.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Nimodipine.Approved, Vet Approved
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Nimodipine is combined with Isosorbide Dinitrate.Approved, Investigational
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Nimodipine is combined with Isosorbide Mononitrate.Approved
IsoxsuprineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Isoxsuprine.Approved, Withdrawn
IsradipineThe serum concentration of Nimodipine can be increased when it is combined with Isradipine.Approved, Investigational
ItraconazoleThe serum concentration of Nimodipine can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Nimodipine can be increased when it is combined with Ivacaftor.Approved
KetanserinKetanserin may increase the hypotensive activities of Nimodipine.Investigational
KetoconazoleThe serum concentration of Nimodipine can be increased when it is combined with Ketoconazole.Approved, Investigational
LabetalolNimodipine may increase the hypotensive activities of Labetalol.Approved
LacidipineNimodipine may increase the hypotensive activities of Lacidipine.Approved, Investigational
LatanoprostNimodipine may increase the hypotensive activities of Latanoprost.Approved, Investigational
LercanidipineNimodipine may increase the hypotensive activities of Lercanidipine.Approved, Investigational
LevobunololThe risk or severity of adverse effects can be increased when Nimodipine is combined with Levobunolol.Approved
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Nimodipine.Approved, Investigational
LevodopaNimodipine may increase the orthostatic hypotensive activities of Levodopa.Approved
LevosimendanThe risk or severity of adverse effects can be increased when Levosimendan is combined with Nimodipine.Approved, Investigational
LinsidomineNimodipine may increase the hypotensive activities of Linsidomine.Experimental
LisinoprilNimodipine may increase the hypotensive activities of Lisinopril.Approved, Investigational
LofexidineNimodipine may increase the hypotensive activities of Lofexidine.Approved, Investigational
LopinavirThe serum concentration of Nimodipine can be increased when it is combined with Lopinavir.Approved
LorpiprazoleThe serum concentration of Nimodipine can be increased when it is combined with Lorpiprazole.Approved
LosartanNimodipine may increase the hypotensive activities of Losartan.Approved
LovastatinThe serum concentration of Nimodipine can be increased when it is combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Nimodipine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Nimodipine can be decreased when it is combined with Lumacaftor.Approved
MacitentanNimodipine may increase the hypotensive activities of Macitentan.Approved
Magnesium hydroxideThe risk or severity of hypotension and neuromuscular blockade can be increased when Nimodipine is combined with Magnesium hydroxide.Approved, Investigational
Magnesium oxideThe risk or severity of hypotension and neuromuscular blockade can be increased when Nimodipine is combined with Magnesium oxide.Approved
Magnesium salicylateThe risk or severity of hypotension and neuromuscular blockade can be increased when Nimodipine is combined with Magnesium salicylate.Approved
Magnesium sulfateThe risk or severity of hypotension and neuromuscular blockade can be increased when Nimodipine is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
ManidipineNimodipine may increase the hypotensive activities of Manidipine.Approved, Investigational
MannitolThe risk or severity of adverse effects can be increased when Nimodipine is combined with Mannitol.Approved, Investigational
MebanazineMebanazine may increase the hypotensive activities of Nimodipine.Withdrawn
MecamylamineMecamylamine may increase the hypotensive activities of Nimodipine.Approved, Investigational
MelatoninMelatonin may decrease the antihypertensive activities of Nimodipine.Approved, Nutraceutical, Vet Approved
MepartricinThe therapeutic efficacy of Mepartricin can be increased when used in combination with Nimodipine.Experimental
MethazolamideThe risk or severity of adverse effects can be increased when Nimodipine is combined with Methazolamide.Approved
MethohexitalThe metabolism of Nimodipine can be increased when combined with Methohexital.Approved
MethoserpidineNimodipine may increase the hypotensive activities of Methoserpidine.Experimental
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Nimodipine.Approved
MethyldopaNimodipine may increase the hypotensive activities of Methyldopa.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Nimodipine.Approved, Investigational
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Nimodipine.Approved, Investigational
MethylphenobarbitalThe metabolism of Nimodipine can be increased when combined with Methylphenobarbital.Approved
MetipranololNimodipine may increase the hypotensive activities of Metipranolol.Approved
MetolazoneNimodipine may increase the hypotensive activities of Metolazone.Approved
MetoprololMetoprolol may increase the hypotensive activities of Nimodipine.Approved, Investigational
MetyrosineNimodipine may increase the hypotensive activities of Metyrosine.Approved
MevastatinThe therapeutic efficacy of Mevastatin can be increased when used in combination with Nimodipine.Experimental
MibefradilNimodipine may increase the hypotensive activities of Mibefradil.Investigational, Withdrawn
MicafunginThe therapeutic efficacy of Micafungin can be increased when used in combination with Nimodipine.Approved, Investigational
MiconazoleThe therapeutic efficacy of Miconazole can be increased when used in combination with Nimodipine.Approved, Investigational, Vet Approved
MifepristoneThe serum concentration of Nimodipine can be increased when it is combined with Mifepristone.Approved, Investigational
MiltefosineThe therapeutic efficacy of Miltefosine can be increased when used in combination with Nimodipine.Approved, Investigational
MinaprineMinaprine may increase the hypotensive activities of Nimodipine.Approved
MinoxidilMinoxidil may increase the hypotensive activities of Nimodipine.Approved, Investigational
MirodenafilMirodenafil may increase the antihypertensive activities of Nimodipine.Investigational
MitotaneThe serum concentration of Nimodipine can be decreased when it is combined with Mitotane.Approved
MoclobemideMoclobemide may increase the hypotensive activities of Nimodipine.Approved, Investigational
MoexiprilNimodipine may increase the hypotensive activities of Moexipril.Approved
MolsidomineMolsidomine may increase the hypotensive activities of Nimodipine.Approved, Investigational
MonensinThe therapeutic efficacy of Monensin can be increased when used in combination with Nimodipine.Vet Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Nimodipine.Approved, Investigational
MoxonidineMoxonidine may increase the hypotensive activities of Nimodipine.Approved, Investigational
MuzolimineNimodipine may increase the hypotensive activities of Muzolimine.Experimental
MyxothiazolThe therapeutic efficacy of Myxothiazol can be increased when used in combination with Nimodipine.Experimental
NabiloneThe risk or severity of adverse effects can be increased when Nabilone is combined with Nimodipine.Approved, Investigational
NadololNimodipine may increase the hypotensive activities of Nadolol.Approved
NafcillinThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Nafcillin.Approved, Investigational
NaftifineThe therapeutic efficacy of Naftifine can be increased when used in combination with Nimodipine.Approved
NaftopidilNimodipine may increase the hypotensive activities of Naftopidil.Investigational
NatamycinThe therapeutic efficacy of Natamycin can be increased when used in combination with Nimodipine.Approved
NebivololNimodipine may increase the hypotensive activities of Nebivolol.Approved, Investigational
NefazodoneThe serum concentration of Nimodipine can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Nimodipine can be increased when it is combined with Nelfinavir.Approved
NesiritideThe risk or severity of adverse effects can be increased when Nimodipine is combined with Nesiritide.Approved, Investigational
NetupitantThe serum concentration of Nimodipine can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe serum concentration of Nimodipine can be increased when it is combined with Nevirapine.Approved
NialamideNialamide may increase the hypotensive activities of Nimodipine.Withdrawn
NicardipineNimodipine may increase the hypotensive activities of Nicardipine.Approved, Investigational
NicorandilNicorandil may increase the hypotensive activities of Nimodipine.Approved, Investigational
NifedipineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Nifedipine.Approved
NifuratelThe therapeutic efficacy of Nifuratel can be increased when used in combination with Nimodipine.Experimental
NiguldipineNimodipine may increase the hypotensive activities of Niguldipine.Experimental
Nikkomycin ZThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Nimodipine.Investigational
NilotinibThe serum concentration of Nimodipine can be increased when it is combined with Nilotinib.Approved, Investigational
NilvadipineNimodipine may increase the hypotensive activities of Nilvadipine.Approved, Investigational
NisoldipineNimodipine may increase the hypotensive activities of Nisoldipine.Approved
NitrendipineNimodipine may increase the hypotensive activities of Nitrendipine.Approved, Investigational
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Nimodipine.Approved
NitroglycerinThe risk or severity of adverse effects can be increased when Nimodipine is combined with Nitroglycerin.Approved, Investigational
NitroprussideNimodipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
NitroxolineThe therapeutic efficacy of Nitroxoline can be increased when used in combination with Nimodipine.Approved
NystatinThe therapeutic efficacy of Nystatin can be increased when used in combination with Nimodipine.Approved, Vet Approved
ObinutuzumabNimodipine may increase the hypotensive activities of Obinutuzumab.Approved, Investigational
OctamoxinOctamoxin may increase the hypotensive activities of Nimodipine.Withdrawn
OlaparibThe serum concentration of Nimodipine can be increased when it is combined with Olaparib.Approved
OlmesartanOlmesartan may increase the hypotensive activities of Nimodipine.Approved, Investigational
OmapatrilatNimodipine may increase the hypotensive activities of Omapatrilat.Investigational
OmoconazoleThe therapeutic efficacy of Omoconazole can be increased when used in combination with Nimodipine.Experimental
OsimertinibThe serum concentration of Nimodipine can be increased when it is combined with Osimertinib.Approved
OxiconazoleThe therapeutic efficacy of Oxiconazole can be increased when used in combination with Nimodipine.Approved
OxprenololNimodipine may increase the hypotensive activities of Oxprenolol.Approved
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Nimodipine.Approved, Vet Approved
PafuramidineThe therapeutic efficacy of Pafuramidine can be increased when used in combination with Nimodipine.Investigational
PalbociclibThe serum concentration of Nimodipine can be increased when it is combined with Palbociclib.Approved, Investigational
PapaverineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Papaverine.Approved, Investigational
PargylinePargyline may increase the hypotensive activities of Nimodipine.Approved
PenbutololNimodipine may increase the hypotensive activities of Penbutolol.Approved, Investigational
PentamidineThe therapeutic efficacy of Pentamidine can be increased when used in combination with Nimodipine.Approved, Investigational
PentobarbitalThe serum concentration of Nimodipine can be decreased when it is combined with Pentobarbital.Approved, Investigational, Vet Approved
PentoliniumNimodipine may increase the hypotensive activities of Pentolinium.Approved
PentoxifyllinePentoxifylline may increase the hypotensive activities of Nimodipine.Approved, Investigational
PerindoprilNimodipine may increase the hypotensive activities of Perindopril.Approved
PhenelzinePhenelzine may increase the hypotensive activities of Nimodipine.Approved
PheniprazinePheniprazine may increase the hypotensive activities of Nimodipine.Withdrawn
PhenobarbitalThe serum concentration of Nimodipine can be decreased when it is combined with Phenobarbital.Approved, Investigational
PhenoxybenzamineNimodipine may increase the hypotensive activities of Phenoxybenzamine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Nimodipine.Withdrawn
PhentolamineNimodipine may increase the hypotensive activities of Phentolamine.Approved
PhenytoinThe serum concentration of Nimodipine can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PinacidilPinacidil may increase the hypotensive activities of Nimodipine.Approved
PindololNimodipine may increase the hypotensive activities of Pindolol.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Nimodipine.Approved, Investigational
PirlindolePirlindole may increase the hypotensive activities of Nimodipine.Approved
PivhydrazinePivhydrazine may increase the hypotensive activities of Nimodipine.Withdrawn
Platelet Activating FactorNimodipine may increase the hypotensive activities of Platelet Activating Factor.Experimental
PolythiazideNimodipine may increase the hypotensive activities of Polythiazide.Approved
PosaconazoleThe serum concentration of Nimodipine can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleThe risk or severity of adverse effects can be increased when Pramipexole is combined with Nimodipine.Approved, Investigational
PrazosinPrazosin may increase the hypotensive activities of Nimodipine.Approved
PrimidoneThe serum concentration of Nimodipine can be decreased when it is combined with Primidone.Approved, Vet Approved
ProcarbazineProcarbazine may increase the hypotensive activities of Nimodipine.Approved, Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Nimodipine.Approved, Investigational, Vet Approved
PropranololNimodipine may increase the hypotensive activities of Propranolol.Approved, Investigational
PyrrolnitrinThe therapeutic efficacy of Pyrrolnitrin can be increased when used in combination with Nimodipine.Experimental
QuetiapineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Quetiapine.Approved
QuinaprilNimodipine may increase the hypotensive activities of Quinapril.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Nimodipine.Approved, Investigational
QuinineQuinine may increase the hypotensive activities of Nimodipine.Approved
RadicicolThe therapeutic efficacy of Radicicol can be increased when used in combination with Nimodipine.Experimental
RamiprilRamipril may increase the hypotensive activities of Nimodipine.Approved
RanolazineThe serum concentration of Nimodipine can be increased when it is combined with Ranolazine.Approved, Investigational
RasagilineRasagiline may increase the hypotensive activities of Nimodipine.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Nimodipine.Approved
RemikirenRemikiren may increase the hypotensive activities of Nimodipine.Approved
RescinnamineNimodipine may increase the hypotensive activities of Rescinnamine.Approved
ReserpineReserpine may increase the hypotensive activities of Nimodipine.Approved, Investigational
RifabutinThe serum concentration of Nimodipine can be decreased when it is combined with Rifabutin.Approved, Investigational
RifampicinThe serum concentration of Nimodipine can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Nimodipine can be decreased when it is combined with Rifapentine.Approved, Investigational
RifaximinThe risk or severity of hypotension can be increased when Rifaximin is combined with Nimodipine.Approved, Investigational
RilmenidineRilmenidine may increase the hypotensive activities of Nimodipine.Approved, Investigational
RiociguatNimodipine may increase the hypotensive activities of Riociguat.Approved
RisperidoneNimodipine may increase the hypotensive activities of Risperidone.Approved, Investigational
RituximabNimodipine may increase the hypotensive activities of Rituximab.Approved
RopiniroleThe risk or severity of adverse effects can be increased when Ropinirole is combined with Nimodipine.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Nimodipine.Approved
RotigotineThe risk or severity of adverse effects can be increased when Rotigotine is combined with Nimodipine.Approved
RucaparibThe serum concentration of Nimodipine can be increased when it is combined with Rucaparib.Approved, Investigational
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Nimodipine.Approved
SafrazineSafrazine may increase the hypotensive activities of Nimodipine.Withdrawn
Salicylhydroxamic AcidThe therapeutic efficacy of Salicylhydroxamic Acid can be increased when used in combination with Nimodipine.Experimental
Salicylic acidThe therapeutic efficacy of Salicylic acid can be increased when used in combination with Nimodipine.Approved, Investigational, Vet Approved
SaprisartanNimodipine may increase the hypotensive activities of Saprisartan.Experimental
SaquinavirThe serum concentration of Nimodipine can be increased when it is combined with Saquinavir.Approved, Investigational
SarilumabThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Sarilumab.Approved, Investigational
SecobarbitalThe metabolism of Nimodipine can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineSelegiline may increase the hypotensive activities of Nimodipine.Approved, Investigational, Vet Approved
SelexipagNimodipine may increase the hypotensive activities of Selexipag.Approved
SertaconazoleThe therapeutic efficacy of Sertaconazole can be increased when used in combination with Nimodipine.Approved, Investigational
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Nimodipine.Approved, Vet Approved
SildenafilThe serum concentration of Nimodipine can be increased when it is combined with Sildenafil.Approved, Investigational
SilodosinThe risk or severity of hypotension can be increased when Silodosin is combined with Nimodipine.Approved
SiltuximabThe serum concentration of Nimodipine can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Nimodipine can be increased when it is combined with Simeprevir.Approved
SinefunginThe therapeutic efficacy of Sinefungin can be increased when used in combination with Nimodipine.Experimental
SirolimusThe therapeutic efficacy of Sirolimus can be increased when used in combination with Nimodipine.Approved, Investigational
SitaxentanNimodipine may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
Sodium NitriteThe risk or severity of adverse effects can be increased when Sodium Nitrite is combined with Nimodipine.Approved, Investigational
SotalolThe risk or severity of adverse effects can be increased when Nimodipine is combined with Sotalol.Approved
SpiraprilNimodipine may increase the hypotensive activities of Spirapril.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Nimodipine is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Nimodipine can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StiripentolThe serum concentration of Nimodipine can be increased when it is combined with Stiripentol.Approved
StreptokinaseThe risk or severity of adverse effects can be increased when Streptokinase is combined with Nimodipine.Approved, Investigational
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Nimodipine.Approved, Investigational
SulconazoleThe therapeutic efficacy of Sulconazole can be increased when used in combination with Nimodipine.Approved
SulfisoxazoleThe serum concentration of Nimodipine can be increased when it is combined with Sulfisoxazole.Approved, Vet Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Nimodipine.Approved, Investigational
TadalafilTadalafil may increase the antihypertensive activities of Nimodipine.Approved, Investigational
TalinololNimodipine may increase the hypotensive activities of Talinolol.Investigational
TamsulosinThe risk or severity of hypotension can be increased when Tamsulosin is combined with Nimodipine.Approved, Investigational
TavaboroleThe therapeutic efficacy of Tavaborole can be increased when used in combination with Nimodipine.Approved, Investigational
TelaprevirThe serum concentration of Nimodipine can be increased when it is combined with Telaprevir.Approved, Withdrawn
TelithromycinThe serum concentration of Nimodipine can be increased when it is combined with Telithromycin.Approved
TelmisartanNimodipine may increase the hypotensive activities of Telmisartan.Approved, Investigational
TemocaprilNimodipine may increase the hypotensive activities of Temocapril.Experimental, Investigational
TerazosinThe risk or severity of hypotension can be increased when Terazosin is combined with Nimodipine.Approved
TerbinafineThe therapeutic efficacy of Terbinafine can be increased when used in combination with Nimodipine.Approved, Investigational, Vet Approved
TerconazoleThe therapeutic efficacy of Terconazole can be increased when used in combination with Nimodipine.Approved
TerlipressinNimodipine may increase the hypotensive activities of Terlipressin.Approved, Investigational
TetrahydropalmatineNimodipine may increase the hypotensive activities of Tetrahydropalmatine.Investigational
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Nimodipine.Approved, Investigational, Withdrawn
TheodrenalineNimodipine may increase the hypotensive activities of Theodrenaline.Investigational
ThiamylalThe metabolism of Nimodipine can be increased when combined with Thiamylal.Approved, Vet Approved
ThiopentalThe metabolism of Nimodipine can be increased when combined with Thiopental.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Nimodipine.Approved, Withdrawn
ThymolThe therapeutic efficacy of Thymol can be increased when used in combination with Nimodipine.Approved
TiboloneNimodipine may increase the hypotensive activities of Tibolone.Approved, Investigational
TiclopidineThe serum concentration of Nimodipine can be increased when it is combined with Ticlopidine.Approved
TicrynafenNimodipine may increase the hypotensive activities of Ticrynafen.Withdrawn
TimololTimolol may increase the hypotensive activities of Nimodipine.Approved
TioconazoleThe therapeutic efficacy of Tioconazole can be increased when used in combination with Nimodipine.Approved
TizanidineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Tizanidine.Approved, Investigational
TocilizumabThe serum concentration of Nimodipine can be decreased when it is combined with Tocilizumab.Approved
TolazolineNimodipine may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Nimodipine.Approved, Withdrawn
TolciclateThe therapeutic efficacy of Tolciclate can be increased when used in combination with Nimodipine.Experimental
TolnaftateThe therapeutic efficacy of Tolnaftate can be increased when used in combination with Nimodipine.Approved, Investigational, Vet Approved
TolonidineNimodipine may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Nimodipine.Approved
TorasemideTorasemide may increase the hypotensive activities of Nimodipine.Approved
TrandolaprilNimodipine may increase the hypotensive activities of Trandolapril.Approved
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Nimodipine.Experimental
TranylcypromineTranylcypromine may increase the hypotensive activities of Nimodipine.Approved, Investigational
TravoprostTravoprost may increase the hypotensive activities of Nimodipine.Approved
TreprostinilTreprostinil may increase the hypotensive activities of Nimodipine.Approved, Investigational
TretinoinThe risk or severity of adverse effects can be increased when Tretinoin is combined with Nimodipine.Approved, Investigational, Nutraceutical
TriamtereneThe risk or severity of adverse effects can be increased when Triamterene is combined with Nimodipine.Approved
TrichlormethiazideNimodipine may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrimazosinTrimazosin may increase the hypotensive activities of Nimodipine.Experimental
TrimethaphanTrimethaphan may increase the hypotensive activities of Nimodipine.Approved, Investigational
TrimetrexateThe therapeutic efficacy of Trimetrexate can be increased when used in combination with Nimodipine.Approved, Investigational
UdenafilUdenafil may increase the antihypertensive activities of Nimodipine.Approved, Investigational
UnoprostoneNimodipine may increase the hypotensive activities of Unoprostone.Approved, Investigational
UrapidilUrapidil may increase the hypotensive activities of Nimodipine.Investigational
ValsartanValsartan may increase the hypotensive activities of Nimodipine.Approved, Investigational
VardenafilVardenafil may increase the antihypertensive activities of Nimodipine.Approved
VemurafenibThe serum concentration of Nimodipine can be decreased when it is combined with Vemurafenib.Approved
VenlafaxineThe serum concentration of Nimodipine can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Nimodipine can be increased when it is combined with Verapamil.Approved
VincamineNimodipine may increase the hypotensive activities of Vincamine.Experimental
VinpocetineNimodipine may increase the hypotensive activities of Vinpocetine.Investigational
VoriconazoleThe serum concentration of Nimodipine can be increased when it is combined with Voriconazole.Approved, Investigational
XipamideNimodipine may increase the hypotensive activities of Xipamide.Experimental
XylometazolineNimodipine may increase the hypotensive activities of Xylometazoline.Approved, Investigational
YohimbineYohimbine may decrease the antihypertensive activities of Nimodipine.Approved, Investigational, Vet Approved
ZiprasidoneThe serum concentration of Nimodipine can be increased when it is combined with Ziprasidone.Approved
ZofenoprilNimodipine may increase the hypotensive activities of Zofenopril.Experimental
Food Interactions
  • Grapefruit down regulates post-translational expression of CYP3A4, the major metabolizing enzyme of nimodipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of nimodipine and may cause toxicity. Avoid grapefruit products while on this medication.
  • Take at the same time each day, with or without food, but always in the same manner.

References

General References
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  2. Allen GS, Ahn HS, Preziosi TJ, Battye R, Boone SC, Boone SC, Chou SN, Kelly DL, Weir BK, Crabbe RA, Lavik PJ, Rosenbloom SB, Dorsey FC, Ingram CR, Mellits DE, Bertsch LA, Boisvert DP, Hundley MB, Johnson RK, Strom JA, Transou CR: Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med. 1983 Mar 17;308(11):619-24. [PubMed:6338383]
  3. Belfort MA, Anthony J, Saade GR, Allen JC Jr: A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. N Engl J Med. 2003 Jan 23;348(4):304-11. [PubMed:12540643]
  4. Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc. 2009 Sep;46(3):239-44. doi: 10.3340/jkns.2009.46.3.239. Epub 2009 Sep 30. [PubMed:19844625]
  5. Tomassoni D, Lanari A, Silvestrelli G, Traini E, Amenta F: Nimodipine and its use in cerebrovascular disease: evidence from recent preclinical and controlled clinical studies. Clin Exp Hypertens. 2008 Nov;30(8):744-66. doi: 10.1080/10641960802580232. [PubMed:19021025]
  6. Vergouwen MD, Vermeulen M, Roos YB: Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage: a systematic review. Lancet Neurol. 2006 Dec;5(12):1029-32. [PubMed:17110283]
External Links
Human Metabolome Database
HMDB0014537
KEGG Drug
D00438
KEGG Compound
C07267
PubChem Compound
4497
PubChem Substance
46508497
ChemSpider
4341
BindingDB
50011690
ChEBI
7575
ChEMBL
CHEMBL1428
Therapeutic Targets Database
DAP000306
PharmGKB
PA450633
IUPHAR
2523
Guide to Pharmacology
GtP Drug Page
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Nimodipine
ATC Codes
C08CA06 — Nimodipine
AHFS Codes
  • 24:28.08 — Dihydropyridines
FDA label
Download (504 KB)
MSDS
Download (73.3 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableProgranulin Mutation Carriers1
1CompletedTreatmentAIDS-Related Dementia Complex / Human Immunodeficiency Virus (HIV) Infections1
1CompletedTreatmentCocaine-Related Disorders1
1, 2CompletedTreatmentRuptured Berry Aneurysm / Ruptured Cerebral Aneurysm1
2CompletedTreatmentCocaine-Related Disorders1
2TerminatedTreatmentInfertilities1
2WithdrawnTreatmentAcute Cerebrovascular Accidents / Vasospasm1
4CompletedTreatmentDementias1
4RecruitingTreatmentReversible cerebral vasoconstriction syndrome1
4TerminatedTreatmentDepression1
4Unknown StatusPreventionMild Cognitive Impairment (MCI) / Strokes1
4Unknown StatusTreatmentCerebral Infarctions1
Not AvailableCompletedPreventionProphylaxis of preeclampsia1
Not AvailableCompletedTreatmentAnovulatory cycle / Polycystic Ovarian Syndrome / Unexplained Infertility1
Not AvailableRecruitingNot AvailableSubarachnoid Hemorrhage, Aneurysmal1
Not AvailableTerminatedTreatmentMild Cognitive Impairment (MCI)1

Pharmacoeconomics

Manufacturers
  • Banner pharmacaps inc
  • Barr laboratories inc
  • Sun pharmaceutical industries inc
  • Bayer pharmaceuticals corp
Packagers
Dosage forms
FormRouteStrength
CapsuleOral30 mg/1
Capsule, liquid filledOral30 mg/1
TabletOral30 mg
CapsuleOral30 mg
LiquidIntravenous.2 mg
LiquidIntravenous0.2 mg
SolutionOral30 mg/10mL
SolutionOral60 mg/20mL
Prices
Unit descriptionCostUnit
NiMODipine 100 30 mg capsule Box952.07USD box
Nimotop 30 mg capsule9.87USD capsule
Nimodipine 30 mg capsule9.69USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)125 °CNot Available
logP3.05MASUMOTO,K ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.012 mg/mLALOGPS
logP3.41ALOGPS
logP2.54ChemAxon
logS-4.5ALOGPS
pKa (Strongest Basic)5.41ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area119.68 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity112.38 m3·mol-1ChemAxon
Polarizability43.17 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9387
Blood Brain Barrier-0.9358
Caco-2 permeable-0.5838
P-glycoprotein substrateSubstrate0.752
P-glycoprotein inhibitor IInhibitor0.9287
P-glycoprotein inhibitor IIInhibitor0.9098
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.8151
CYP450 2D6 substrateNon-substrate0.9118
CYP450 3A4 substrateSubstrate0.7571
CYP450 1A2 substrateInhibitor0.9108
CYP450 2C9 inhibitorInhibitor0.8949
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorInhibitor0.8248
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8557
Ames testNon AMES toxic0.5976
CarcinogenicityNon-carcinogens0.6953
BiodegradationNot ready biodegradable0.8797
Rat acute toxicity2.5326 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.6468
hERG inhibition (predictor II)Non-inhibitor0.8734
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0006-0149000000-2a019013c0386ca13362

Taxonomy

Description
This compound belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. These are compounds containing a dihydropyridine moiety bearing a carboxylic acid group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Hydropyridines
Direct Parent
Dihydropyridinecarboxylic acids and derivatives
Alternative Parents
Nitrobenzenes / Nitroaromatic compounds / Dicarboxylic acids and derivatives / Vinylogous amides / Enoate esters / Amino acids and derivatives / Propargyl-type 1,3-dipolar organic compounds / Azacyclic compounds / Dialkyl ethers / Dialkylamines
show 7 more
Substituents
Dihydropyridinecarboxylic acid derivative / Nitrobenzene / Nitroaromatic compound / Monocyclic benzene moiety / Dicarboxylic acid or derivatives / Benzenoid / Vinylogous amide / Enoate ester / Alpha,beta-unsaturated carboxylic ester / Amino acid or derivatives
show 25 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
C-nitro compound, diester, dihydropyridine (CHEBI:7575)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated calcium channel activity
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Gene Name
CACNA1C
Uniprot ID
Q13936
Uniprot Name
Voltage-dependent L-type calcium channel subunit alpha-1C
Molecular Weight
248974.1 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  2. Marchetti C, Usai C: High affinity block by nimodipine of the internal calcium elevation in chronically depolarized rat cerebellar granule neurons. Neurosci Lett. 1996 Mar 29;207(2):77-80. [PubMed:8731425]
  3. Weant KA, Ramsey CN 3rd, Cook AM: Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage. Pharmacotherapy. 2010 Apr;30(4):405-17. doi: 10.1592/phco.30.4.405. [PubMed:20334460]
  4. Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA: Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4174-80. doi: 10.1167/iovs.09-4613. Epub 2010 Mar 24. [PubMed:20335610]
  5. Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc. 2009 Sep;46(3):239-44. doi: 10.3340/jkns.2009.46.3.239. Epub 2009 Sep 30. [PubMed:19844625]
  6. Kumar R, Mehra R, Ray SB: L-type calcium channel blockers, morphine and pain: Newer insights. Indian J Anaesth. 2010 Mar;54(2):127-31. doi: 10.4103/0019-5049.63652. [PubMed:20661350]
  7. Keyrouz SG, Diringer MN: Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage. Crit Care. 2007;11(4):220. [PubMed:17705883]
  8. Striessnig, J. (2004). Ca 2+ channel blockers. In Encyclopedic reference of molecular pharmacology (pp. 201-207). Berlin: Springer. [ISBN:9783540298328]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated calcium channel activity involved sa node cell action potential
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Gene Name
CACNA1D
Uniprot ID
Q01668
Uniprot Name
Voltage-dependent L-type calcium channel subunit alpha-1D
Molecular Weight
245138.75 Da
References
  1. Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J: Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Mol Pharmacol. 2009 Feb;75(2):407-14. doi: 10.1124/mol.108.049981. Epub 2008 Nov 24. [PubMed:19029287]
  2. Weant KA, Ramsey CN 3rd, Cook AM: Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage. Pharmacotherapy. 2010 Apr;30(4):405-17. doi: 10.1592/phco.30.4.405. [PubMed:20334460]
  3. Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA: Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4174-80. doi: 10.1167/iovs.09-4613. Epub 2010 Mar 24. [PubMed:20335610]
  4. Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc. 2009 Sep;46(3):239-44. doi: 10.3340/jkns.2009.46.3.239. Epub 2009 Sep 30. [PubMed:19844625]
  5. Kumar R, Mehra R, Ray SB: L-type calcium channel blockers, morphine and pain: Newer insights. Indian J Anaesth. 2010 Mar;54(2):127-31. doi: 10.4103/0019-5049.63652. [PubMed:20661350]
  6. Keyrouz SG, Diringer MN: Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage. Crit Care. 2007;11(4):220. [PubMed:17705883]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated calcium channel activity
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Gene Name
CACNA1F
Uniprot ID
O60840
Uniprot Name
Voltage-dependent L-type calcium channel subunit alpha-1F
Molecular Weight
220675.9 Da
References
  1. Weant KA, Ramsey CN 3rd, Cook AM: Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage. Pharmacotherapy. 2010 Apr;30(4):405-17. doi: 10.1592/phco.30.4.405. [PubMed:20334460]
  2. Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA: Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4174-80. doi: 10.1167/iovs.09-4613. Epub 2010 Mar 24. [PubMed:20335610]
  3. Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc. 2009 Sep;46(3):239-44. doi: 10.3340/jkns.2009.46.3.239. Epub 2009 Sep 30. [PubMed:19844625]
  4. Kumar R, Mehra R, Ray SB: L-type calcium channel blockers, morphine and pain: Newer insights. Indian J Anaesth. 2010 Mar;54(2):127-31. doi: 10.4103/0019-5049.63652. [PubMed:20661350]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated calcium channel activity
Specific Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Gene Name
CACNA1S
Uniprot ID
Q13698
Uniprot Name
Voltage-dependent L-type calcium channel subunit alpha-1S
Molecular Weight
212348.1 Da
References
  1. Peterson BZ, Catterall WA: Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore. Mol Pharmacol. 2006 Aug;70(2):667-75. Epub 2006 May 4. [PubMed:16675661]
  2. Weant KA, Ramsey CN 3rd, Cook AM: Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage. Pharmacotherapy. 2010 Apr;30(4):405-17. doi: 10.1592/phco.30.4.405. [PubMed:20334460]
  3. Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA: Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4174-80. doi: 10.1167/iovs.09-4613. Epub 2010 Mar 24. [PubMed:20335610]
  4. Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc. 2009 Sep;46(3):239-44. doi: 10.3340/jkns.2009.46.3.239. Epub 2009 Sep 30. [PubMed:19844625]
  5. Kumar R, Mehra R, Ray SB: L-type calcium channel blockers, morphine and pain: Newer insights. Indian J Anaesth. 2010 Mar;54(2):127-31. doi: 10.4103/0019-5049.63652. [PubMed:20661350]
  6. Keyrouz SG, Diringer MN: Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage. Crit Care. 2007;11(4):220. [PubMed:17705883]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated calcium channel activity
Specific Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and ina...
Gene Name
CACNB1
Uniprot ID
Q02641
Uniprot Name
Voltage-dependent L-type calcium channel subunit beta-1
Molecular Weight
65712.995 Da
References
  1. Weant KA, Ramsey CN 3rd, Cook AM: Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage. Pharmacotherapy. 2010 Apr;30(4):405-17. doi: 10.1592/phco.30.4.405. [PubMed:20334460]
  2. Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA: Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4174-80. doi: 10.1167/iovs.09-4613. Epub 2010 Mar 24. [PubMed:20335610]
  3. Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc. 2009 Sep;46(3):239-44. doi: 10.3340/jkns.2009.46.3.239. Epub 2009 Sep 30. [PubMed:19844625]
  4. Kumar R, Mehra R, Ray SB: L-type calcium channel blockers, morphine and pain: Newer insights. Indian J Anaesth. 2010 Mar;54(2):127-31. doi: 10.4103/0019-5049.63652. [PubMed:20661350]
  5. Keyrouz SG, Diringer MN: Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage. Crit Care. 2007;11(4):220. [PubMed:17705883]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated calcium channel activity
Specific Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and ina...
Gene Name
CACNB2
Uniprot ID
Q08289
Uniprot Name
Voltage-dependent L-type calcium channel subunit beta-2
Molecular Weight
73579.925 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  2. Weant KA, Ramsey CN 3rd, Cook AM: Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage. Pharmacotherapy. 2010 Apr;30(4):405-17. doi: 10.1592/phco.30.4.405. [PubMed:20334460]
  3. Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc. 2009 Sep;46(3):239-44. doi: 10.3340/jkns.2009.46.3.239. Epub 2009 Sep 30. [PubMed:19844625]
  4. Kumar R, Mehra R, Ray SB: L-type calcium channel blockers, morphine and pain: Newer insights. Indian J Anaesth. 2010 Mar;54(2):127-31. doi: 10.4103/0019-5049.63652. [PubMed:20661350]
  5. Keyrouz SG, Diringer MN: Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage. Crit Care. 2007;11(4):220. [PubMed:17705883]
  6. Striessnig, J. (2004). Ca 2+ channel blockers. In Encyclopedic reference of molecular pharmacology (pp. 201-207). Berlin: Springer. [ISBN:9783540298328]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated calcium channel activity
Specific Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and ina...
Gene Name
CACNB3
Uniprot ID
P54284
Uniprot Name
Voltage-dependent L-type calcium channel subunit beta-3
Molecular Weight
54531.425 Da
References
  1. Weant KA, Ramsey CN 3rd, Cook AM: Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage. Pharmacotherapy. 2010 Apr;30(4):405-17. doi: 10.1592/phco.30.4.405. [PubMed:20334460]
  2. Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA: Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4174-80. doi: 10.1167/iovs.09-4613. Epub 2010 Mar 24. [PubMed:20335610]
  3. Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc. 2009 Sep;46(3):239-44. doi: 10.3340/jkns.2009.46.3.239. Epub 2009 Sep 30. [PubMed:19844625]
  4. Kumar R, Mehra R, Ray SB: L-type calcium channel blockers, morphine and pain: Newer insights. Indian J Anaesth. 2010 Mar;54(2):127-31. doi: 10.4103/0019-5049.63652. [PubMed:20661350]
  5. Keyrouz SG, Diringer MN: Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage. Crit Care. 2007;11(4):220. [PubMed:17705883]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated calcium channel activity
Specific Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and ina...
Gene Name
CACNB4
Uniprot ID
O00305
Uniprot Name
Voltage-dependent L-type calcium channel subunit beta-4
Molecular Weight
58168.625 Da
References
  1. Weant KA, Ramsey CN 3rd, Cook AM: Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage. Pharmacotherapy. 2010 Apr;30(4):405-17. doi: 10.1592/phco.30.4.405. [PubMed:20334460]
  2. Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA: Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4174-80. doi: 10.1167/iovs.09-4613. Epub 2010 Mar 24. [PubMed:20335610]
  3. Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc. 2009 Sep;46(3):239-44. doi: 10.3340/jkns.2009.46.3.239. Epub 2009 Sep 30. [PubMed:19844625]
  4. Kumar R, Mehra R, Ray SB: L-type calcium channel blockers, morphine and pain: Newer insights. Indian J Anaesth. 2010 Mar;54(2):127-31. doi: 10.4103/0019-5049.63652. [PubMed:20661350]
  5. Keyrouz SG, Diringer MN: Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage. Crit Care. 2007;11(4):220. [PubMed:17705883]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Zinc ion binding
Specific Function
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates targ...
Gene Name
NR3C2
Uniprot ID
P08235
Uniprot Name
Mineralocorticoid receptor
Molecular Weight
107066.575 Da
References
  1. Dietz JD, Du S, Bolten CW, Payne MA, Xia C, Blinn JR, Funder JW, Hu X: A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity. Hypertension. 2008 Mar;51(3):742-8. doi: 10.1161/HYPERTENSIONAHA.107.103580. Epub 2008 Feb 4. [PubMed:18250364]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Transcription regulatory region dna binding
Specific Function
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes...
Gene Name
AHR
Uniprot ID
P35869
Uniprot Name
Aryl hydrocarbon receptor
Molecular Weight
96146.705 Da
References
  1. Hu W, Sorrentino C, Denison MS, Kolaja K, Fielden MR: Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol Pharmacol. 2007 Jun;71(6):1475-86. Epub 2007 Feb 27. [PubMed:17327465]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on June 13, 2005 07:24 / Updated on February 21, 2018 17:10