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Identification
NameMetamizole
Accession NumberDB04817
TypeSmall Molecule
GroupsWithdrawn
DescriptionMetamizole, formerly marketed as Dimethone tablets and injection, Protemp oral liquid, and other drug products, was associated with potentially fatal agranulocytosis. Approvals of the NDA's for dipyrone drug products were withdrawn on June 27, 1977 (see the Federal Register of June 17, 1977 (42 FR 30893)). Withdrawn from the Canadian market in 1963.
Structure
Thumb
Synonyms
Dipyrone
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AlgocalminNot Available
AlgozoneNot Available
AnalginNot Available
DimethoneNot Available
DipironaNot Available
Neo-MelubrinaNot Available
NovalginNot Available
OptalginNot Available
ProtempNot Available
PyralginNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Metamizole sodium
68-89-3
Thumb
  • InChI Key: DJGAAPFSPWAYTJ-UHFFFAOYSA-M
  • Monoisotopic Mass: 333.07592138
  • Average Mass: 333.339
DBSALT000332
Categories
UNII934T64RMNJ
CAS number50567-35-6
WeightAverage: 333.339
Monoisotopic: 333.07592138
Chemical FormulaC13H16N3NaO4S
InChI KeyDJGAAPFSPWAYTJ-UHFFFAOYSA-M
InChI
InChI=1S/C13H17N3O4S.Na/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;/h4-8H,9H2,1-3H3,(H,18,19,20);/q;+1/p-1
IUPAC Name
sodium [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate
SMILES
[Na+].CN(CS([O-])(=O)=O)C1=C(C)N(C)N(C1=O)C1=CC=CC=C1
Pharmacology
IndicationUsed in the past as a powerful painkiller and fever reducer.
Structured Indications Not Available
PharmacodynamicsDipyrone is a non-steroidal anti-inflammatory drug (NSAID), commonly used in the past as a powerful painkiller and fever reducer.
Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
Prostaglandin G/H synthase 1ProteinunknownNot AvailableHumanP23219 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when Metamizole is combined with 16-Bromoepiandrosterone.Investigational
19-norandrostenedioneThe risk or severity of adverse effects can be increased when Metamizole is combined with 19-norandrostenedione.Experimental, Illicit
4-AndrostenedioneThe risk or severity of adverse effects can be increased when Metamizole is combined with 4-Androstenedione.Experimental, Illicit
5-androstenedioneThe risk or severity of adverse effects can be increased when Metamizole is combined with 5-androstenedione.Experimental, Illicit
AbciximabMetamizole may increase the anticoagulant activities of Abciximab.Approved
AcebutololMetamizole may decrease the antihypertensive activities of Acebutolol.Approved
AceclofenacThe risk or severity of adverse effects can be increased when Metamizole is combined with Aceclofenac.Approved
AcenocoumarolMetamizole may increase the anticoagulant activities of Acenocoumarol.Approved
AcetovanilloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Acetovanillone.Investigational
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Metamizole.Approved, Vet Approved
AclarubicinMetamizole may decrease the excretion rate of Aclarubicin which could result in a higher serum level.Investigational
AdapaleneThe risk or severity of adverse effects can be increased when Adapalene is combined with Metamizole.Approved
AlclometasoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Alclometasone.Approved
AldesleukinThe risk or severity of adverse effects can be increased when Metamizole is combined with Aldesleukin.Approved
AldosteroneThe risk or severity of adverse effects can be increased when Metamizole is combined with Aldosterone.Experimental
AlemtuzumabThe risk or severity of adverse effects can be increased when Metamizole is combined with Alemtuzumab.Approved, Investigational
Alendronic acidThe risk or severity of adverse effects can be increased when Metamizole is combined with Alendronic acid.Approved
AliskirenMetamizole may decrease the antihypertensive activities of Aliskiren.Approved, Investigational
AlprenololMetamizole may decrease the antihypertensive activities of Alprenolol.Approved, Withdrawn
AlprostadilThe therapeutic efficacy of Alprostadil can be decreased when used in combination with Metamizole.Approved, Investigational
AltretamineThe risk or severity of adverse effects can be increased when Metamizole is combined with Altretamine.Approved
AmcinonideThe risk or severity of adverse effects can be increased when Metamizole is combined with Amcinonide.Approved
AmikacinMetamizole may decrease the excretion rate of Amikacin which could result in a higher serum level.Approved, Vet Approved
AmilorideMetamizole may decrease the antihypertensive activities of Amiloride.Approved
AmrubicinMetamizole may decrease the excretion rate of Amrubicin which could result in a higher serum level.Approved, Investigational
AmsacrineThe risk or severity of adverse effects can be increased when Metamizole is combined with Amsacrine.Approved
AncrodMetamizole may increase the anticoagulant activities of Ancrod.Investigational
AnecortaveThe risk or severity of adverse effects can be increased when Metamizole is combined with Anecortave.Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Metamizole is combined with Anisodamine.Investigational
annamycinMetamizole may decrease the excretion rate of annamycin which could result in a higher serum level.Investigational
AntipyrineThe risk or severity of adverse effects can be increased when Antipyrine is combined with Metamizole.Approved
Antithrombin III humanMetamizole may increase the anticoagulant activities of Antithrombin III human.Approved
Aop200704Metamizole may decrease the antihypertensive activities of Aop200704.Investigational
ApixabanMetamizole may increase the anticoagulant activities of Apixaban.Approved
ApramycinMetamizole may decrease the excretion rate of Apramycin which could result in a higher serum level.Experimental, Vet Approved
ApremilastThe risk or severity of adverse effects can be increased when Metamizole is combined with Apremilast.Approved, Investigational
ArbekacinMetamizole may decrease the excretion rate of Arbekacin which could result in a higher serum level.Approved
ArdeparinMetamizole may increase the anticoagulant activities of Ardeparin.Approved, Withdrawn
ArgatrobanMetamizole may increase the anticoagulant activities of Argatroban.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Metamizole.Approved, Investigational
ArotinololMetamizole may decrease the antihypertensive activities of Arotinolol.Approved
Arsenic trioxideThe risk or severity of adverse effects can be increased when Metamizole is combined with Arsenic trioxide.Approved, Investigational
AtenololMetamizole may decrease the antihypertensive activities of Atenolol.Approved
AzacitidineThe risk or severity of adverse effects can be increased when Metamizole is combined with Azacitidine.Approved, Investigational
AzapropazoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Azapropazone.Withdrawn
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Metamizole.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Metamizole.Approved
BalsalazideMetamizole may increase the nephrotoxic activities of Balsalazide.Approved, Investigational
BecaplerminMetamizole may increase the anticoagulant activities of Becaplermin.Approved, Investigational
BeclomethasoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Beclomethasone.Investigational
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Metamizole is combined with Beclomethasone dipropionate.Approved, Investigational
BefunololMetamizole may decrease the antihypertensive activities of Befunolol.Experimental
BelinostatThe risk or severity of adverse effects can be increased when Metamizole is combined with Belinostat.Approved, Investigational
BenazeprilThe risk or severity of adverse effects can be increased when Benazepril is combined with Metamizole.Approved, Investigational
BendamustineThe risk or severity of adverse effects can be increased when Metamizole is combined with Bendamustine.Approved, Investigational
BendroflumethiazideThe therapeutic efficacy of Bendroflumethiazide can be decreased when used in combination with Metamizole.Approved
BenoxaprofenThe risk or severity of adverse effects can be increased when Benoxaprofen is combined with Metamizole.Withdrawn
BeraprostThe therapeutic efficacy of Beraprost can be decreased when used in combination with Metamizole.Investigational
BetamethasoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Betamethasone.Approved, Vet Approved
BetaxololMetamizole may decrease the antihypertensive activities of Betaxolol.Approved
Betulinic AcidThe risk or severity of adverse effects can be increased when Metamizole is combined with Betulinic Acid.Investigational
BevacizumabThe risk or severity of adverse effects can be increased when Metamizole is combined with Bevacizumab.Approved, Investigational
BevantololMetamizole may decrease the antihypertensive activities of Bevantolol.Approved
BexaroteneThe risk or severity of adverse effects can be increased when Metamizole is combined with Bexarotene.Approved, Investigational
BimatoprostThe therapeutic efficacy of Bimatoprost can be decreased when used in combination with Metamizole.Approved, Investigational
BisoprololMetamizole may decrease the antihypertensive activities of Bisoprolol.Approved
BivalirudinMetamizole may increase the anticoagulant activities of Bivalirudin.Approved, Investigational
BlinatumomabThe risk or severity of adverse effects can be increased when Metamizole is combined with Blinatumomab.Approved
BopindololMetamizole may decrease the antihypertensive activities of Bopindolol.Approved
BortezomibThe risk or severity of adverse effects can be increased when Metamizole is combined with Bortezomib.Approved, Investigational
BosutinibThe risk or severity of adverse effects can be increased when Metamizole is combined with Bosutinib.Approved
BromfenacThe risk or severity of adverse effects can be increased when Bromfenac is combined with Metamizole.Approved
BucillamineThe risk or severity of adverse effects can be increased when Metamizole is combined with Bucillamine.Investigational
BucindololMetamizole may decrease the antihypertensive activities of Bucindolol.Investigational
BudesonideThe risk or severity of adverse effects can be increased when Metamizole is combined with Budesonide.Approved
BufuralolMetamizole may decrease the antihypertensive activities of Bufuralol.Experimental, Investigational
BumetanideMetamizole may decrease the diuretic activities of Bumetanide.Approved
BupranololMetamizole may decrease the antihypertensive activities of Bupranolol.Approved
BusulfanThe risk or severity of adverse effects can be increased when Metamizole is combined with Busulfan.Approved, Investigational
CabazitaxelThe risk or severity of adverse effects can be increased when Metamizole is combined with Cabazitaxel.Approved
CandesartanThe risk or severity of adverse effects can be increased when Candesartan is combined with Metamizole.Approved
CandoxatrilThe risk or severity of adverse effects can be increased when Candoxatril is combined with Metamizole.Experimental
CapecitabineThe risk or severity of adverse effects can be increased when Metamizole is combined with Capecitabine.Approved, Investigational
CaptoprilThe risk or severity of adverse effects can be increased when Captopril is combined with Metamizole.Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Metamizole is combined with Carbamazepine.Approved, Investigational
CarboplatinThe risk or severity of adverse effects can be increased when Metamizole is combined with Carboplatin.Approved
Carboprost TromethamineThe therapeutic efficacy of Carboprost Tromethamine can be decreased when used in combination with Metamizole.Approved
CarfilzomibThe risk or severity of adverse effects can be increased when Metamizole is combined with Carfilzomib.Approved
CarmustineThe risk or severity of adverse effects can be increased when Metamizole is combined with Carmustine.Approved
CarprofenThe risk or severity of adverse effects can be increased when Carprofen is combined with Metamizole.Approved, Vet Approved, Withdrawn
CarteololMetamizole may decrease the antihypertensive activities of Carteolol.Approved
CarvedilolMetamizole may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
CastanospermineThe risk or severity of adverse effects can be increased when Castanospermine is combined with Metamizole.Experimental
CelecoxibThe risk or severity of adverse effects can be increased when Metamizole is combined with Celecoxib.Approved, Investigational
CeliprololMetamizole may decrease the antihypertensive activities of Celiprolol.Approved, Investigational
CertoparinMetamizole may increase the anticoagulant activities of Certoparin.Approved
ChlorambucilThe risk or severity of adverse effects can be increased when Metamizole is combined with Chlorambucil.Approved
ChloramphenicolThe risk or severity of adverse effects can be increased when Metamizole is combined with Chloramphenicol.Approved, Vet Approved
ChloroquineThe risk or severity of adverse effects can be increased when Chloroquine is combined with Metamizole.Approved, Vet Approved
ChlorothiazideThe therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Metamizole.Approved, Vet Approved
ChlorthalidoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Metamizole.Approved
CholestyramineCholestyramine can cause a decrease in the absorption of Metamizole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CiclesonideThe risk or severity of adverse effects can be increased when Metamizole is combined with Ciclesonide.Approved, Investigational
CilazaprilThe risk or severity of adverse effects can be increased when Cilazapril is combined with Metamizole.Approved
CinoxacinMetamizole may increase the neuroexcitatory activities of Cinoxacin.Approved, Withdrawn
CiprofloxacinMetamizole may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
CisplatinThe risk or severity of adverse effects can be increased when Metamizole is combined with Cisplatin.Approved
Citric AcidMetamizole may increase the anticoagulant activities of Citric Acid.Nutraceutical, Vet Approved
CladribineThe risk or severity of adverse effects can be increased when Metamizole is combined with Cladribine.Approved, Investigational
ClobetasolThe risk or severity of adverse effects can be increased when Metamizole is combined with Clobetasol.Investigational
Clobetasol propionateThe risk or severity of adverse effects can be increased when Metamizole is combined with Clobetasol propionate.Approved
ClocortoloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Clocortolone.Approved
ClodronateThe risk or severity of adverse effects can be increased when Metamizole is combined with Clodronate.Approved, Investigational, Vet Approved
ClofarabineThe risk or severity of adverse effects can be increased when Metamizole is combined with Clofarabine.Approved, Investigational
ClonixinThe risk or severity of adverse effects can be increased when Metamizole is combined with Clonixin.Approved
CloprostenolThe therapeutic efficacy of Cloprostenol can be decreased when used in combination with Metamizole.Vet Approved
ColesevelamColesevelam can cause a decrease in the absorption of Metamizole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Metamizole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Cortisone acetateThe risk or severity of adverse effects can be increased when Metamizole is combined with Cortisone acetate.Approved
CurcuminThe risk or severity of adverse effects can be increased when Metamizole is combined with Curcumin.Investigational
CyclophosphamideThe risk or severity of adverse effects can be increased when Metamizole is combined with Cyclophosphamide.Approved, Investigational
CyclosporineMetamizole may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CytarabineThe risk or severity of adverse effects can be increased when Metamizole is combined with Cytarabine.Approved, Investigational
D-LimoneneThe risk or severity of adverse effects can be increased when Metamizole is combined with D-Limonene.Investigational
Dabigatran etexilateMetamizole may increase the anticoagulant activities of Dabigatran etexilate.Approved
DacarbazineThe risk or severity of adverse effects can be increased when Metamizole is combined with Dacarbazine.Approved, Investigational
DactinomycinThe risk or severity of adverse effects can be increased when Metamizole is combined with Dactinomycin.Approved
DalteparinMetamizole may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidMetamizole may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DasatinibThe risk or severity of adverse effects can be increased when Metamizole is combined with Dasatinib.Approved, Investigational
DaunorubicinThe risk or severity of adverse effects can be increased when Metamizole is combined with Daunorubicin.Approved
DecitabineThe risk or severity of adverse effects can be increased when Metamizole is combined with Decitabine.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Metamizole is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe risk or severity of adverse effects can be increased when Metamizole is combined with dehydroepiandrosterone sulfate.Investigational
DesirudinMetamizole may increase the anticoagulant activities of Desirudin.Approved
DesmopressinThe risk or severity of adverse effects can be increased when Metamizole is combined with Desmopressin.Approved
DesoximetasoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Desoximetasone.Approved
Desoxycorticosterone acetateThe risk or severity of adverse effects can be increased when Metamizole is combined with Desoxycorticosterone acetate.Approved
Desoxycorticosterone PivalateThe risk or severity of adverse effects can be increased when Metamizole is combined with Desoxycorticosterone Pivalate.Experimental, Vet Approved
DexamethasoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Dexamethasone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe risk or severity of adverse effects can be increased when Metamizole is combined with Dexamethasone isonicotinate.Vet Approved
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Metamizole.Approved
DexrazoxaneThe risk or severity of adverse effects can be increased when Metamizole is combined with Dexrazoxane.Approved, Withdrawn
DextranMetamizole may increase the anticoagulant activities of Dextran.Approved, Vet Approved
Dextran 40Metamizole may increase the anticoagulant activities of Dextran 40.Approved
Dextran 70Metamizole may increase the anticoagulant activities of Dextran 70.Approved
Dextran 75Metamizole may increase the anticoagulant activities of Dextran 75.Approved
DiclofenacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Metamizole.Approved, Vet Approved
DicoumarolMetamizole may increase the anticoagulant activities of Dicoumarol.Approved
DiflorasoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Diflorasone.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Diflunisal is combined with Metamizole.Approved
DifluocortoloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Difluocortolone.Approved
DifluprednateThe risk or severity of adverse effects can be increased when Metamizole is combined with Difluprednate.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Metamizole.Approved
DihydrostreptomycinMetamizole may decrease the excretion rate of Dihydrostreptomycin which could result in a higher serum level.Vet Approved
DinoprostThe therapeutic efficacy of Dinoprost can be decreased when used in combination with Metamizole.Investigational
Dinoprost TromethamineThe therapeutic efficacy of Dinoprost Tromethamine can be decreased when used in combination with Metamizole.Approved, Vet Approved
DinoprostoneThe therapeutic efficacy of Dinoprostone can be decreased when used in combination with Metamizole.Approved
DinutuximabThe risk or severity of adverse effects can be increased when Metamizole is combined with Dinutuximab.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Metamizole is combined with Docetaxel.Approved, Investigational
DoxorubicinThe risk or severity of adverse effects can be increased when Metamizole is combined with Doxorubicin.Approved, Investigational
DrospirenoneMetamizole may increase the hyperkalemic activities of Drospirenone.Approved
DroxicamThe risk or severity of adverse effects can be increased when Metamizole is combined with Droxicam.Approved
DuvelisibThe risk or severity of adverse effects can be increased when Metamizole is combined with Duvelisib.Investigational
E6201The risk or severity of adverse effects can be increased when Metamizole is combined with E6201.Investigational
EbselenThe risk or severity of adverse effects can be increased when Metamizole is combined with Ebselen.Investigational
Edetic AcidMetamizole may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanMetamizole may increase the anticoagulant activities of Edoxaban.Approved
EnalaprilThe risk or severity of adverse effects can be increased when Enalapril is combined with Metamizole.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Enalaprilat is combined with Metamizole.Approved
EnoxacinMetamizole may increase the neuroexcitatory activities of Enoxacin.Approved
EnoxaparinMetamizole may increase the anticoagulant activities of Enoxaparin.Approved
EpirizoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Epirizole.Approved
EpirubicinThe risk or severity of adverse effects can be increased when Metamizole is combined with Epirubicin.Approved
EplerenoneMetamizole may decrease the antihypertensive activities of Eplerenone.Approved
EpoprostenolThe therapeutic efficacy of Epoprostenol can be decreased when used in combination with Metamizole.Approved
EprosartanThe risk or severity of adverse effects can be increased when Eprosartan is combined with Metamizole.Approved
EquileninThe risk or severity of adverse effects can be increased when Metamizole is combined with Equilenin.Experimental
EquilinThe risk or severity of adverse effects can be increased when Metamizole is combined with Equilin.Approved
EribulinThe risk or severity of adverse effects can be increased when Metamizole is combined with Eribulin.Approved, Investigational
EsmololMetamizole may decrease the antihypertensive activities of Esmolol.Approved
EstroneThe risk or severity of adverse effects can be increased when Metamizole is combined with Estrone.Approved
Estrone sulfateThe risk or severity of adverse effects can be increased when Metamizole is combined with Estrone sulfate.Approved
Etacrynic acidMetamizole may decrease the diuretic activities of Etacrynic acid.Approved
EtanerceptThe risk or severity of adverse effects can be increased when Etanercept is combined with Metamizole.Approved, Investigational
Ethyl biscoumacetateMetamizole may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Etidronic acidThe risk or severity of adverse effects can be increased when Metamizole is combined with Etidronic acid.Approved
EtodolacThe risk or severity of adverse effects can be increased when Metamizole is combined with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Metamizole is combined with Etofenamate.Approved
EtoposideThe risk or severity of adverse effects can be increased when Metamizole is combined with Etoposide.Approved
EtoricoxibThe risk or severity of adverse effects can be increased when Metamizole is combined with Etoricoxib.Approved, Investigational
Evening primrose oilThe risk or severity of adverse effects can be increased when Metamizole is combined with Evening primrose oil.Approved
EverolimusThe risk or severity of adverse effects can be increased when Metamizole is combined with Everolimus.Approved
exisulindThe risk or severity of adverse effects can be increased when Metamizole is combined with exisulind.Investigational
FenbufenThe risk or severity of adverse effects can be increased when Metamizole is combined with Fenbufen.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Fenoprofen is combined with Metamizole.Approved
FenprostaleneThe therapeutic efficacy of Fenprostalene can be decreased when used in combination with Metamizole.Vet Approved
FleroxacinMetamizole may increase the neuroexcitatory activities of Fleroxacin.Approved
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Metamizole.Approved, Withdrawn
FloxuridineThe risk or severity of adverse effects can be increased when Metamizole is combined with Floxuridine.Approved
fluasteroneThe risk or severity of adverse effects can be increased when Metamizole is combined with fluasterone.Investigational
FlucytosineThe risk or severity of adverse effects can be increased when Metamizole is combined with Flucytosine.Approved
FludarabineThe risk or severity of adverse effects can be increased when Metamizole is combined with Fludarabine.Approved
FludrocortisoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Fludrocortisone.Approved
FluindioneMetamizole may increase the anticoagulant activities of Fluindione.Investigational
FlumequineMetamizole may increase the neuroexcitatory activities of Flumequine.Withdrawn
FlumethasoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Flumethasone.Approved, Vet Approved
FlunisolideThe risk or severity of adverse effects can be increased when Metamizole is combined with Flunisolide.Approved, Investigational
FlunixinThe risk or severity of adverse effects can be increased when Metamizole is combined with Flunixin.Vet Approved
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Metamizole is combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluocinonideThe risk or severity of adverse effects can be increased when Metamizole is combined with Fluocinonide.Approved, Investigational
FluocortoloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Fluocortolone.Approved, Withdrawn
FluorometholoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Fluorometholone.Approved
FluorouracilThe risk or severity of adverse effects can be increased when Metamizole is combined with Fluorouracil.Approved
FluprednideneThe risk or severity of adverse effects can be increased when Metamizole is combined with Fluprednidene.Approved, Withdrawn
FluprednisoloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Fluprednisolone.Approved
FluprostenolThe therapeutic efficacy of Fluprostenol can be decreased when used in combination with Metamizole.Vet Approved
FlurandrenolideThe risk or severity of adverse effects can be increased when Metamizole is combined with Flurandrenolide.Approved
FlurbiprofenThe risk or severity of adverse effects can be increased when Flurbiprofen is combined with Metamizole.Approved, Investigational
Fluticasone furoateThe risk or severity of adverse effects can be increased when Metamizole is combined with Fluticasone furoate.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Metamizole is combined with Fluticasone Propionate.Approved
Folic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Metamizole.Approved, Nutraceutical, Vet Approved
FondaparinuxMetamizole may increase the anticoagulant activities of Fondaparinux.Investigational
Fondaparinux sodiumMetamizole may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Metamizole.Experimental
FormestaneThe risk or severity of adverse effects can be increased when Metamizole is combined with Formestane.Approved, Investigational, Withdrawn
FosinoprilThe risk or severity of adverse effects can be increased when Fosinopril is combined with Metamizole.Approved
FramycetinMetamizole may decrease the excretion rate of Framycetin which could result in a higher serum level.Approved
FurosemideMetamizole may decrease the diuretic activities of Furosemide.Approved, Vet Approved
GabexateMetamizole may increase the anticoagulant activities of Gabexate.Investigational
GarenoxacinMetamizole may increase the neuroexcitatory activities of Garenoxacin.Investigational
GatifloxacinMetamizole may increase the neuroexcitatory activities of Gatifloxacin.Approved, Investigational
GemcitabineThe risk or severity of adverse effects can be increased when Metamizole is combined with Gemcitabine.Approved
GemeprostThe therapeutic efficacy of Gemeprost can be decreased when used in combination with Metamizole.Approved, Withdrawn
GemifloxacinMetamizole may increase the neuroexcitatory activities of Gemifloxacin.Approved, Investigational
Gemtuzumab ozogamicinThe risk or severity of adverse effects can be increased when Metamizole is combined with Gemtuzumab ozogamicin.Approved, Investigational, Withdrawn
GeneticinMetamizole may decrease the excretion rate of Geneticin which could result in a higher serum level.Experimental
GentamicinMetamizole may decrease the excretion rate of Gentamicin which could result in a higher serum level.Approved, Vet Approved
GENTAMICIN C1AMetamizole may decrease the excretion rate of GENTAMICIN C1A which could result in a higher serum level.Experimental
GrepafloxacinMetamizole may increase the neuroexcitatory activities of Grepafloxacin.Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Metamizole is combined with Haloperidol.Approved
HE3286The risk or severity of adverse effects can be increased when Metamizole is combined with HE3286.Investigational
HeparinMetamizole may increase the anticoagulant activities of Heparin.Approved, Investigational
HigenamineThe risk or severity of adverse effects can be increased when Metamizole is combined with Higenamine.Investigational
HirulogMetamizole may increase the anticoagulant activities of Hirulog.Experimental
HMPL-004The risk or severity of adverse effects can be increased when Metamizole is combined with HMPL-004.Investigational
HydralazineMetamizole may decrease the antihypertensive activities of Hydralazine.Approved
HydrochlorothiazideThe therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Metamizole.Approved, Vet Approved
HydrocortisoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Hydrocortisone.Approved, Vet Approved
HydroflumethiazideThe therapeutic efficacy of Hydroflumethiazide can be decreased when used in combination with Metamizole.Approved
HydroxyureaThe risk or severity of adverse effects can be increased when Metamizole is combined with Hydroxyurea.Approved
Hygromycin BMetamizole may decrease the excretion rate of Hygromycin B which could result in a higher serum level.Vet Approved
IbandronateThe risk or severity of adverse effects can be increased when Metamizole is combined with Ibandronate.Approved, Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Metamizole is combined with Ibritumomab tiuxetan.Approved
IbrutinibThe risk or severity of adverse effects can be increased when Metamizole is combined with Ibrutinib.Approved
IbuprofenThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Metamizole.Approved
IbuproxamThe risk or severity of adverse effects can be increased when Metamizole is combined with Ibuproxam.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Metamizole is combined with Icatibant.Approved
IdarubicinThe risk or severity of adverse effects can be increased when Metamizole is combined with Idarubicin.Approved
idraparinuxMetamizole may increase the anticoagulant activities of idraparinux.Investigational
IfosfamideThe risk or severity of adverse effects can be increased when Metamizole is combined with Ifosfamide.Approved
IloprostThe therapeutic efficacy of Iloprost can be decreased when used in combination with Metamizole.Approved, Investigational
ImatinibThe risk or severity of adverse effects can be increased when Metamizole is combined with Imatinib.Approved
ImidaprilThe risk or severity of adverse effects can be increased when Imidapril is combined with Metamizole.Investigational
IndapamideThe therapeutic efficacy of Indapamide can be decreased when used in combination with Metamizole.Approved
IndenololMetamizole may decrease the antihypertensive activities of Indenolol.Withdrawn
IndomethacinThe risk or severity of adverse effects can be increased when Indomethacin is combined with Metamizole.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Metamizole is combined with Indoprofen.Withdrawn
INNO-206Metamizole may decrease the excretion rate of INNO-206 which could result in a higher serum level.Investigational
Interferon alfa-n3The risk or severity of adverse effects can be increased when Metamizole is combined with Interferon alfa-n3.Approved, Investigational
Interferon alfacon-1The risk or severity of adverse effects can be increased when Metamizole is combined with Interferon alfacon-1.Approved
IrbesartanThe risk or severity of adverse effects can be increased when Irbesartan is combined with Metamizole.Approved, Investigational
IrinotecanThe risk or severity of adverse effects can be increased when Metamizole is combined with Irinotecan.Approved, Investigational
IsoxicamThe risk or severity of adverse effects can be increased when Metamizole is combined with Isoxicam.Withdrawn
IstaroximeThe risk or severity of adverse effects can be increased when Metamizole is combined with Istaroxime.Investigational
IxabepiloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Ixabepilone.Approved, Investigational
KanamycinMetamizole may decrease the excretion rate of Kanamycin which could result in a higher serum level.Approved, Vet Approved
KebuzoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Kebuzone.Experimental
KetoprofenThe risk or severity of adverse effects can be increased when Ketoprofen is combined with Metamizole.Approved, Vet Approved
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Metamizole.Approved
L-PhenylalanineThe risk or severity of adverse effects can be increased when Metamizole is combined with L-Phenylalanine.Approved, Nutraceutical
LabetalolMetamizole may decrease the antihypertensive activities of Labetalol.Approved
LatanoprostThe therapeutic efficacy of Latanoprost can be decreased when used in combination with Metamizole.Approved, Investigational
LeflunomideThe risk or severity of adverse effects can be increased when Leflunomide is combined with Metamizole.Approved, Investigational
LenalidomideThe risk or severity of adverse effects can be increased when Metamizole is combined with Lenalidomide.Approved
LepirudinMetamizole may increase the anticoagulant activities of Lepirudin.Approved
LevobunololMetamizole may decrease the antihypertensive activities of Levobunolol.Approved
LevofloxacinMetamizole may increase the neuroexcitatory activities of Levofloxacin.Approved, Investigational
LimaprostThe therapeutic efficacy of Limaprost can be decreased when used in combination with Metamizole.Approved
LinezolidThe risk or severity of adverse effects can be increased when Metamizole is combined with Linezolid.Approved, Investigational
LisinoprilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Metamizole.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Metamizole is combined with Lisofylline.Investigational
LithiumThe serum concentration of Lithium can be increased when it is combined with Metamizole.Approved
LomefloxacinMetamizole may increase the neuroexcitatory activities of Lomefloxacin.Approved
LomustineThe risk or severity of adverse effects can be increased when Metamizole is combined with Lomustine.Approved
LornoxicamThe risk or severity of adverse effects can be increased when Metamizole is combined with Lornoxicam.Approved
LosartanThe risk or severity of adverse effects can be increased when Losartan is combined with Metamizole.Approved
LoxoprofenThe risk or severity of adverse effects can be increased when Metamizole is combined with Loxoprofen.Approved
LubiprostoneThe therapeutic efficacy of Lubiprostone can be decreased when used in combination with Metamizole.Approved, Investigational
LumiracoxibThe risk or severity of adverse effects can be increased when Metamizole is combined with Lumiracoxib.Approved, Investigational
LuprostiolThe therapeutic efficacy of Luprostiol can be decreased when used in combination with Metamizole.Vet Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Metamizole.Approved
MasoprocolThe risk or severity of adverse effects can be increased when Masoprocol is combined with Metamizole.Approved
ME-609The risk or severity of adverse effects can be increased when Metamizole is combined with ME-609.Investigational
MechlorethamineThe risk or severity of adverse effects can be increased when Metamizole is combined with Mechlorethamine.Approved
Meclofenamic acidThe risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Metamizole.Approved, Vet Approved
MedrysoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Medrysone.Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Mefenamic acid is combined with Metamizole.Approved
MelengestrolThe risk or severity of adverse effects can be increased when Metamizole is combined with Melengestrol.Vet Approved
MeloxicamThe risk or severity of adverse effects can be increased when Meloxicam is combined with Metamizole.Approved, Vet Approved
MelphalanThe risk or severity of adverse effects can be increased when Metamizole is combined with Melphalan.Approved
MercaptopurineThe risk or severity of adverse effects can be increased when Metamizole is combined with Mercaptopurine.Approved
MesalazineMetamizole may increase the nephrotoxic activities of Mesalazine.Approved
MethimazoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Methimazole.Approved
MethotrexateThe risk or severity of adverse effects can be increased when Methotrexate is combined with Metamizole.Approved
MethyclothiazideThe therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Metamizole.Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Methylprednisolone.Approved, Vet Approved
MetipranololMetamizole may decrease the antihypertensive activities of Metipranolol.Approved
MetolazoneThe therapeutic efficacy of Metolazone can be decreased when used in combination with Metamizole.Approved
MetoprololMetamizole may decrease the antihypertensive activities of Metoprolol.Approved, Investigational
MetrizamideMetamizole may decrease the excretion rate of Metrizamide which could result in a higher serum level.Approved
MisoprostolThe therapeutic efficacy of Misoprostol can be decreased when used in combination with Metamizole.Approved
MitomycinThe risk or severity of adverse effects can be increased when Metamizole is combined with Mitomycin.Approved
MitoxantroneThe risk or severity of adverse effects can be increased when Metamizole is combined with Mitoxantrone.Approved, Investigational
MizoribineThe risk or severity of adverse effects can be increased when Metamizole is combined with Mizoribine.Investigational
MoexiprilThe risk or severity of adverse effects can be increased when Moexipril is combined with Metamizole.Approved
MometasoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Mometasone.Approved, Vet Approved
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Metamizole.Approved
MoxifloxacinMetamizole may increase the neuroexcitatory activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Metamizole.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Metamizole.Approved
NabumetoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Nabumetone.Approved
NadololMetamizole may decrease the antihypertensive activities of Nadolol.Approved
NadroparinMetamizole may increase the anticoagulant activities of Nadroparin.Approved
NafamostatMetamizole may increase the anticoagulant activities of Nafamostat.Investigational
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Metamizole.Approved
Nalidixic AcidMetamizole may increase the neuroexcitatory activities of Nalidixic Acid.Approved
NaproxenThe risk or severity of adverse effects can be increased when Naproxen is combined with Metamizole.Approved, Vet Approved
NCX 1022The risk or severity of adverse effects can be increased when Metamizole is combined with NCX 1022.Investigational
NCX 4016The risk or severity of adverse effects can be increased when Metamizole is combined with NCX 4016.Investigational
NeamineMetamizole may decrease the excretion rate of Neamine which could result in a higher serum level.Experimental
NelarabineThe risk or severity of adverse effects can be increased when Metamizole is combined with Nelarabine.Approved, Investigational
NemonoxacinMetamizole may increase the neuroexcitatory activities of Nemonoxacin.Investigational
NeomycinMetamizole may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
NepafenacThe risk or severity of adverse effects can be increased when Metamizole is combined with Nepafenac.Approved
NetilmicinMetamizole may decrease the excretion rate of Netilmicin which could result in a higher serum level.Approved
Niflumic AcidThe risk or severity of adverse effects can be increased when Niflumic Acid is combined with Metamizole.Approved
NilotinibThe risk or severity of adverse effects can be increased when Metamizole is combined with Nilotinib.Approved, Investigational
NimesulideThe risk or severity of adverse effects can be increased when Nimesulide is combined with Metamizole.Approved, Withdrawn
NitroaspirinThe risk or severity of adverse effects can be increased when Metamizole is combined with Nitroaspirin.Investigational
NorfloxacinMetamizole may increase the neuroexcitatory activities of Norfloxacin.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Metamizole is combined with Obinutuzumab.Approved
OfloxacinMetamizole may increase the neuroexcitatory activities of Ofloxacin.Approved
OlaparibThe risk or severity of adverse effects can be increased when Metamizole is combined with Olaparib.Approved
Oleoyl estroneThe risk or severity of adverse effects can be increased when Metamizole is combined with Oleoyl estrone.Investigational
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Metamizole.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Metamizole.Approved
OlsalazineMetamizole may increase the nephrotoxic activities of Olsalazine.Approved
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Metamizole is combined with Omacetaxine mepesuccinate.Approved
OmapatrilatThe risk or severity of adverse effects can be increased when Omapatrilat is combined with Metamizole.Investigational
OrgoteinThe risk or severity of adverse effects can be increased when Metamizole is combined with Orgotein.Vet Approved
OtamixabanMetamizole may increase the anticoagulant activities of Otamixaban.Investigational
OxaliplatinThe risk or severity of adverse effects can be increased when Metamizole is combined with Oxaliplatin.Approved, Investigational
OxaprozinThe risk or severity of adverse effects can be increased when Oxaprozin is combined with Metamizole.Approved
OxprenololMetamizole may decrease the antihypertensive activities of Oxprenolol.Approved
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Oxyphenbutazone is combined with Metamizole.Withdrawn
PaclitaxelThe risk or severity of adverse effects can be increased when Metamizole is combined with Paclitaxel.Approved, Vet Approved
PalbociclibThe risk or severity of adverse effects can be increased when Metamizole is combined with Palbociclib.Approved
PamidronateThe risk or severity of adverse effects can be increased when Metamizole is combined with Pamidronate.Approved
ParamethasoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Paramethasone.Approved
ParecoxibThe risk or severity of adverse effects can be increased when Metamizole is combined with Parecoxib.Approved
ParomomycinMetamizole may decrease the excretion rate of Paromomycin which could result in a higher serum level.Approved, Investigational
PazufloxacinMetamizole may increase the neuroexcitatory activities of Pazufloxacin.Investigational
PefloxacinMetamizole may increase the neuroexcitatory activities of Pefloxacin.Approved
Peginterferon alfa-2aThe risk or severity of adverse effects can be increased when Metamizole is combined with Peginterferon alfa-2a.Approved, Investigational
Peginterferon alfa-2bThe risk or severity of adverse effects can be increased when Metamizole is combined with Peginterferon alfa-2b.Approved
PemetrexedThe risk or severity of adverse effects can be increased when Metamizole is combined with Pemetrexed.Approved, Investigational
PenbutololMetamizole may decrease the antihypertensive activities of Penbutolol.Approved, Investigational
Pentosan PolysulfateMetamizole may increase the anticoagulant activities of Pentosan Polysulfate.Approved
PentostatinThe risk or severity of adverse effects can be increased when Metamizole is combined with Pentostatin.Approved, Investigational
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Metamizole.Approved
PhenindioneMetamizole may increase the anticoagulant activities of Phenindione.Approved
PhenprocoumonMetamizole may increase the anticoagulant activities of Phenprocoumon.Approved
PhenylbutazoneThe risk or severity of adverse effects can be increased when Phenylbutazone is combined with Metamizole.Approved, Vet Approved
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Metamizole.Approved, Investigational
PindololMetamizole may decrease the antihypertensive activities of Pindolol.Approved
PirarubicinMetamizole may decrease the excretion rate of Pirarubicin which could result in a higher serum level.Investigational
PiretanideMetamizole may decrease the diuretic activities of Piretanide.Experimental
PirfenidoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Pirfenidone.Investigational
PiroxicamThe risk or severity of adverse effects can be increased when Piroxicam is combined with Metamizole.Approved, Investigational
PlicamycinMetamizole may decrease the excretion rate of Plicamycin which could result in a higher serum level.Approved, Withdrawn
PolythiazideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Metamizole.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Metamizole is combined with Pomalidomide.Approved
PonatinibThe risk or severity of adverse effects can be increased when Metamizole is combined with Ponatinib.Approved
PractololMetamizole may decrease the antihypertensive activities of Practolol.Approved
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Metamizole.Approved
PrasteroneThe risk or severity of adverse effects can be increased when Metamizole is combined with Prasterone.Approved, Nutraceutical
PrednicarbateThe risk or severity of adverse effects can be increased when Metamizole is combined with Prednicarbate.Approved
PrednisoloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Prednisolone.Approved, Vet Approved
PrednisoneThe risk or severity of adverse effects can be increased when Metamizole is combined with Prednisone.Approved, Vet Approved
PregnenoloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Pregnenolone.Experimental
ProbenecidThe serum concentration of Metamizole can be increased when it is combined with Probenecid.Approved
ProcarbazineThe risk or severity of adverse effects can be increased when Metamizole is combined with Procarbazine.Approved
PropacetamolThe risk or severity of adverse effects can be increased when Metamizole is combined with Propacetamol.Approved
PropranololMetamizole may decrease the antihypertensive activities of Propranolol.Approved, Investigational
PropylthiouracilThe risk or severity of adverse effects can be increased when Metamizole is combined with Propylthiouracil.Approved
Prostaglandin B2The therapeutic efficacy of Prostaglandin B2 can be decreased when used in combination with Metamizole.Experimental
Prostaglandin D2The therapeutic efficacy of Prostaglandin D2 can be decreased when used in combination with Metamizole.Experimental, Investigational
Prostaglandin G2The therapeutic efficacy of Prostaglandin G2 can be decreased when used in combination with Metamizole.Experimental
ProstaleneThe therapeutic efficacy of Prostalene can be decreased when used in combination with Metamizole.Vet Approved
Protein CMetamizole may increase the anticoagulant activities of Protein C.Approved
Protein S humanMetamizole may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeMetamizole may increase the anticoagulant activities of Protocatechualdehyde.Approved
PrulifloxacinMetamizole may increase the neuroexcitatory activities of Prulifloxacin.Investigational
PTC299The risk or severity of adverse effects can be increased when Metamizole is combined with PTC299.Investigational
PuromycinMetamizole may decrease the excretion rate of Puromycin which could result in a higher serum level.Experimental
QuinaprilThe risk or severity of adverse effects can be increased when Quinapril is combined with Metamizole.Approved, Investigational
QuinethazoneThe therapeutic efficacy of Quinethazone can be decreased when used in combination with Metamizole.Approved
RaltitrexedThe risk or severity of adverse effects can be increased when Metamizole is combined with Raltitrexed.Approved, Investigational
RamiprilThe risk or severity of adverse effects can be increased when Ramipril is combined with Metamizole.Approved
RescinnamineThe risk or severity of adverse effects can be increased when Rescinnamine is combined with Metamizole.Approved
ResveratrolThe risk or severity of adverse effects can be increased when Resveratrol is combined with Metamizole.Experimental, Investigational
ReviparinMetamizole may increase the anticoagulant activities of Reviparin.Approved
RibostamycinMetamizole may decrease the excretion rate of Ribostamycin which could result in a higher serum level.Approved
RimexoloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Rimexolone.Approved
RisedronateThe risk or severity of adverse effects can be increased when Metamizole is combined with Risedronate.Approved, Investigational
RituximabThe risk or severity of adverse effects can be increased when Metamizole is combined with Rituximab.Approved
RivaroxabanMetamizole may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibThe risk or severity of adverse effects can be increased when Metamizole is combined with Rofecoxib.Investigational, Withdrawn
RosoxacinMetamizole may increase the neuroexcitatory activities of Rosoxacin.Approved
RuxolitinibThe risk or severity of adverse effects can be increased when Metamizole is combined with Ruxolitinib.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Metamizole.Approved
SalicylamideThe risk or severity of adverse effects can be increased when Metamizole is combined with Salicylamide.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Metamizole.Approved, Vet Approved
SalsalateThe risk or severity of adverse effects can be increased when Salsalate is combined with Metamizole.Approved
SaprisartanThe risk or severity of adverse effects can be increased when Saprisartan is combined with Metamizole.Experimental
SaralasinThe risk or severity of adverse effects can be increased when Saralasin is combined with Metamizole.Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Metamizole.Approved
SeratrodastThe risk or severity of adverse effects can be increased when Metamizole is combined with Seratrodast.Approved, Investigational
SirolimusThe risk or severity of adverse effects can be increased when Metamizole is combined with Sirolimus.Approved, Investigational
SisomicinMetamizole may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
SorafenibThe risk or severity of adverse effects can be increased when Metamizole is combined with Sorafenib.Approved, Investigational
SotalolMetamizole may decrease the antihypertensive activities of Sotalol.Approved
SP1049CMetamizole may decrease the excretion rate of SP1049C which could result in a higher serum level.Investigational
SparfloxacinMetamizole may increase the neuroexcitatory activities of Sparfloxacin.Approved
SpectinomycinMetamizole may decrease the excretion rate of Spectinomycin which could result in a higher serum level.Approved, Vet Approved
SpiraprilThe risk or severity of adverse effects can be increased when Spirapril is combined with Metamizole.Approved
SpironolactoneMetamizole may decrease the antihypertensive activities of Spironolactone.Approved
SRT501The risk or severity of adverse effects can be increased when Metamizole is combined with SRT501.Investigational
StreptomycinMetamizole may decrease the excretion rate of Streptomycin which could result in a higher serum level.Approved, Vet Approved
StreptozocinThe risk or severity of adverse effects can be increased when Metamizole is combined with Streptozocin.Approved
SulfasalazineMetamizole may increase the nephrotoxic activities of Sulfasalazine.Approved
SulindacThe risk or severity of adverse effects can be increased when Sulindac is combined with Metamizole.Approved
SulodexideMetamizole may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SulprostoneThe therapeutic efficacy of Sulprostone can be decreased when used in combination with Metamizole.Investigational
SuprofenThe risk or severity of adverse effects can be increased when Suprofen is combined with Metamizole.Approved, Withdrawn
TacrolimusThe risk or severity of adverse effects can be increased when Metamizole is combined with Tacrolimus.Approved, Investigational
TacrolimusMetamizole may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
TafluprostThe therapeutic efficacy of Tafluprost can be decreased when used in combination with Metamizole.Approved
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Metamizole.Approved
TasosartanThe risk or severity of adverse effects can be increased when Tasosartan is combined with Metamizole.Approved
Technetium tc 99m etidronateThe risk or severity of adverse effects can be increased when Metamizole is combined with Technetium tc 99m etidronate.Approved
Technetium Tc-99m MedronateThe risk or severity of adverse effects can be increased when Metamizole is combined with Technetium Tc-99m Medronate.Approved
Tedizolid PhosphateThe risk or severity of adverse effects can be increased when Metamizole is combined with Tedizolid Phosphate.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Telmisartan is combined with Metamizole.Approved, Investigational
TemafloxacinMetamizole may increase the neuroexcitatory activities of Temafloxacin.Withdrawn
TemocaprilThe risk or severity of adverse effects can be increased when Temocapril is combined with Metamizole.Experimental, Investigational
TemozolomideThe risk or severity of adverse effects can be increased when Metamizole is combined with Temozolomide.Approved, Investigational
TemsirolimusThe risk or severity of adverse effects can be increased when Metamizole is combined with Temsirolimus.Approved
TeniposideThe risk or severity of adverse effects can be increased when Metamizole is combined with Teniposide.Approved
TenofovirThe risk or severity of adverse effects can be increased when Metamizole is combined with Tenofovir.Approved, Investigational
TenoxicamThe risk or severity of adverse effects can be increased when Tenoxicam is combined with Metamizole.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Metamizole is combined with Tepoxalin.Vet Approved
TeriflunomideThe risk or severity of adverse effects can be increased when Metamizole is combined with Teriflunomide.Approved
ThalidomideThe risk or severity of adverse effects can be increased when Metamizole is combined with Thalidomide.Approved, Investigational, Withdrawn
ThiotepaThe risk or severity of adverse effects can be increased when Metamizole is combined with Thiotepa.Approved
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Tiaprofenic acid is combined with Metamizole.Approved
TiludronateThe risk or severity of adverse effects can be increased when Metamizole is combined with Tiludronate.Approved, Vet Approved
TimololMetamizole may decrease the antihypertensive activities of Timolol.Approved
TinoridineThe risk or severity of adverse effects can be increased when Metamizole is combined with Tinoridine.Investigational
TioguanineThe risk or severity of adverse effects can be increased when Metamizole is combined with Tioguanine.Approved
TixocortolThe risk or severity of adverse effects can be increased when Metamizole is combined with Tixocortol.Approved
TobramycinMetamizole may decrease the excretion rate of Tobramycin which could result in a higher serum level.Approved, Investigational
TofacitinibThe risk or severity of adverse effects can be increased when Metamizole is combined with Tofacitinib.Approved, Investigational
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Metamizole is combined with Tolfenamic Acid.Approved
TolmetinThe risk or severity of adverse effects can be increased when Tolmetin is combined with Metamizole.Approved
TopotecanThe risk or severity of adverse effects can be increased when Metamizole is combined with Topotecan.Approved, Investigational
TorasemideMetamizole may decrease the diuretic activities of Torasemide.Approved
TositumomabThe risk or severity of adverse effects can be increased when Metamizole is combined with Tositumomab.Approved
TrabectedinThe risk or severity of adverse effects can be increased when Metamizole is combined with Trabectedin.Approved, Investigational
TrandolaprilThe risk or severity of adverse effects can be increased when Trandolapril is combined with Metamizole.Approved
TranilastThe risk or severity of adverse effects can be increased when Metamizole is combined with Tranilast.Approved, Investigational
Trastuzumab emtansineThe risk or severity of adverse effects can be increased when Metamizole is combined with Trastuzumab emtansine.Approved
TravoprostThe therapeutic efficacy of Travoprost can be decreased when used in combination with Metamizole.Approved
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Metamizole.Approved, Investigational
TriamcinoloneThe risk or severity of adverse effects can be increased when Metamizole is combined with Triamcinolone.Approved, Vet Approved
TriamtereneMetamizole may decrease the antihypertensive activities of Triamterene.Approved
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Metamizole.Approved, Vet Approved
Trisalicylate-cholineThe risk or severity of adverse effects can be increased when Trisalicylate-choline is combined with Metamizole.Approved
TrovafloxacinMetamizole may increase the neuroexcitatory activities of Trovafloxacin.Approved, Withdrawn
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Metamizole.Approved
ValdecoxibThe risk or severity of adverse effects can be increased when Metamizole is combined with Valdecoxib.Investigational, Withdrawn
ValrubicinMetamizole may decrease the excretion rate of Valrubicin which could result in a higher serum level.Approved
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Metamizole.Approved, Investigational
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Metamizole.Approved
VinblastineThe risk or severity of adverse effects can be increased when Metamizole is combined with Vinblastine.Approved
VindesineThe risk or severity of adverse effects can be increased when Metamizole is combined with Vindesine.Approved
VinorelbineThe risk or severity of adverse effects can be increased when Metamizole is combined with Vinorelbine.Approved, Investigational
VorinostatThe risk or severity of adverse effects can be increased when Metamizole is combined with Vorinostat.Approved, Investigational
WarfarinMetamizole may increase the anticoagulant activities of Warfarin.Approved
XimelagatranMetamizole may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
Ym150Metamizole may increase the anticoagulant activities of Ym150.Investigational
ZaltoprofenThe risk or severity of adverse effects can be increased when Metamizole is combined with Zaltoprofen.Approved
ZidovudineThe risk or severity of adverse effects can be increased when Metamizole is combined with Zidovudine.Approved
ZileutonThe risk or severity of adverse effects can be increased when Zileuton is combined with Metamizole.Approved, Investigational, Withdrawn
Zoledronic acidThe risk or severity of adverse effects can be increased when Metamizole is combined with Zoledronic acid.Approved
ZomepiracThe risk or severity of adverse effects can be increased when Metamizole is combined with Zomepirac.Withdrawn
ZorubicinMetamizole may decrease the excretion rate of Zorubicin which could result in a higher serum level.Experimental
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesN02BB02N02BB72N02BB52
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7868
Blood Brain Barrier+0.8896
Caco-2 permeable-0.5869
P-glycoprotein substrateNon-substrate0.8148
P-glycoprotein inhibitor INon-inhibitor0.828
P-glycoprotein inhibitor IINon-inhibitor0.8107
Renal organic cation transporterNon-inhibitor0.921
CYP450 2C9 substrateNon-substrate0.8588
CYP450 2D6 substrateNon-substrate0.7959
CYP450 3A4 substrateSubstrate0.6035
CYP450 1A2 substrateNon-inhibitor0.7153
CYP450 2C9 inhibitorNon-inhibitor0.7064
CYP450 2D6 inhibitorNon-inhibitor0.8562
CYP450 2C19 inhibitorNon-inhibitor0.6768
CYP450 3A4 inhibitorNon-inhibitor0.9297
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8506
Ames testAMES toxic0.7763
CarcinogenicityCarcinogens 0.8197
BiodegradationReady biodegradable0.7192
Rat acute toxicity2.6224 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8411
hERG inhibition (predictor II)Non-inhibitor0.6724
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility5.8 mg/mLALOGPS
logP1.07ALOGPS
logP-0.82ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)-1.2ChemAxon
pKa (Strongest Basic)-0.44ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area83.99 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity78.92 m3·mol-1ChemAxon
Polarizability31.11 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassAzoles
Sub ClassPyrazoles
Direct ParentPhenylpyrazoles
Alternative Parents
Substituents
  • Phenylpyrazole
  • Dialkylarylamine
  • Benzenoid
  • Pyrazolinone
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Vinylogous amide
  • Alkanesulfonic acid
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonic acid
  • Tertiary amine
  • Lactam
  • Azacycle
  • Hydrocarbon derivative
  • Organic alkali metal salt
  • Organic sodium salt
  • Organic salt
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Organic zwitterion
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on September 11, 2007 14:09 / Updated on August 17, 2016 12:24