Community Acquired Pneumonia (CAP)

Also known as: Community Aquired Pneumonia / Community Acquired Pneumonia / Pneumonia, Community-Acquired / Community-Acquired Pneumonia / Community-Acquired Pneumonia (CAP) / Pneumonia / Pneumonia NOS / Pulmonitis

DrugDrug NameDrug Description
DB01060AmoxicillinA broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation.
DB00207AzithromycinAzithromycin is a semi-synthetic macrolide antibiotic of the azalide class. Like other macrolide antibiotics, azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the process of translation. Its effects may be bacteriostatic or bactericidal depending of the organism and the drug concentration. Its long half life, which enables once daily dosing and shorter administration durations, is a property distinct from other macrolides.
DB01327CefazolinA semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
DB01066CefditorenCefditoren is a third-generation cephalosporin antibiotic for oral use. It is commonly marketed under the trade name Spectracef by Cornerstone BioPharma.
DB00671CefiximeCefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
DB00493CefotaximeCefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
DB01416CefpodoximeCefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
DB01150CefprozilCefprozil is a cephalosporin antibiotic. It can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections.
DB06590Ceftaroline fosamilCeftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia.
DB04918CeftobiproleCeftobiprole is an experimental cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus. It was discovered by Basilea Pharmaceutica and is being developed by Johnson & Johnson Pharmaceutical Research and Development. Ceftobiprole is the first cephalosporin to demonstrate clinical efficacy in patients with infections due to methicillin-resistant staphylococci and, if approved by regulatory authorities, is expected to be a useful addition to the armamentarium of agents for the treatment of complicated skin infections and pneumonia.
DB01212CeftriaxoneA broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears. [PubChem]
DB01211ClarithromycinClarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB01190ClindamycinClindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB00303ErtapenemErtapenem is a carbapenem antibiotic marketed by Merck as Invanz®. It is structurally very similar to meropenem in that it possess a 1-beta-methyl group. [Wikipedia]
DB00199ErythromycinErythromycin is a macrolide antibiotic produced by Saccharopolyspora erythraea (formerly Streptomyces erythraeus). It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB01155GemifloxacinGemifloxacin is an oral broad-spectrum quinolone antibacterial agent used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are essential for bacterial growth.
DB01137LevofloxacinA synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
DB00601LinezolidLinezolid is a synthetic antibiotic, the first of the oxazolidinone class, used for the treatment of infections caused by multi-resistant bacteria including streptococcus and methicillin-resistant Staphylococcus aureus (MRSA). The drug works by inhibiting the initiation of bacterial protein synthesis.
DB00218MoxifloxacinMoxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
DB01165OfloxacinA synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
DB00713OxacillinAn antibiotic similar to flucloxacillin used in resistant staphylococci infections. [PubChem]
DB00417PhenoxymethylpenicillinPhenoxymethylpenicillin (Penicillin V) is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
DB09324SulbactamSulbactam is a β-lactamase inhibitor given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys antibiotic activity.
DB00560TigecyclineTigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. It was given a U.S. Food and Drug Administration (FDA) fast-track approval and was approved on June 17, 2005. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus.
DrugDrug NameTargetType
DB01060AmoxicillinPenicillin-binding protein 1Atarget
DB01060AmoxicillinCytochrome P450 2C19enzyme
DB01060AmoxicillinSolute carrier family 15 member 1transporter
DB01060AmoxicillinSolute carrier family 15 member 2transporter
DB01060AmoxicillinSolute carrier family 22 member 6transporter
DB00207Azithromycin23S rRNAtarget
DB00207Azithromycin50S ribosomal protein L22target
DB00207Azithromycin50S ribosomal protein L4target
DB00207AzithromycinMultidrug resistance protein 1transporter
DB00207AzithromycinCytochrome P450 2A6enzyme
DB00207AzithromycinCytochrome P450 3A4enzyme
DB00207AzithromycinCytochrome P450 1A2enzyme
DB00207AzithromycinProtein-arginine deiminase type-4target
DB01327CefazolinSerum paraoxonase/arylesterase 1target
DB01327CefazolinSerum albumincarrier
DB01327CefazolinSolute carrier family 22 member 6transporter
DB01327CefazolinSolute carrier family 22 member 8transporter
DB01327CefazolinSolute carrier family 22 member 11transporter
DB01327CefazolinPenicillin-binding protein 1Atarget
DB01327CefazolinPenicillin-binding protein 1Btarget
DB01327CefazolinPenicillin-binding protein 2target
DB01327CefazolinPenicillin-binding protein 1Ctarget
DB01327CefazolinPeptidoglycan synthase FtsItarget
DB01327CefazolinMultidrug resistance-associated protein 4transporter
DB01327CefazolinThiopurine S-methyltransferaseenzyme
DB01327CefazolinInterleukin-15target
DB01327CefazolinInterleukin-2target
DB01066CefditorenPenicillin-binding protein 1Atarget
DB01066CefditorenPenicillin-binding protein 2Btarget
DB00671CefiximePenicillin-binding protein 2target
DB00671CefiximeSolute carrier family 22 member 5transporter
DB00671CefiximeSolute carrier family 15 member 1transporter
DB00671CefiximeSolute carrier family 15 member 2transporter
DB00493CefotaximePenicillin-binding protein 3target
DB00493CefotaximeSolute carrier family 15 member 1transporter
DB00493CefotaximeSolute carrier family 15 member 2transporter
DB00493CefotaximeSolute carrier family 22 member 6transporter
DB00493CefotaximeSolute carrier family 22 member 8transporter
DB00493CefotaximeSolute carrier family 22 member 11transporter
DB00493CefotaximeSolute carrier family 22 member 7transporter
DB00493CefotaximePenicillin-binding protein 1btarget
DB00493CefotaximePenicillin-binding protein 2atarget
DB00493CefotaximePenicillin-binding protein 1Atarget
DB00493CefotaximePenicillin-binding protein 2Btarget
DB00493CefotaximeSolute carrier family 22 member 6target
DB00493CefotaximeSolute carrier family 22 member 8target
DB00493CefotaximeSolute carrier family 22 member 11target
DB00493CefotaximeSolute carrier family 22 member 7target
DB00493CefotaximeSolute carrier family 15 member 1target
DB00493CefotaximeSerum albumintarget
DB00493CefotaximeBeta-lactamasetarget
DB00493CefotaximeSolute carrier family 15 member 2target
DB01416CefpodoximePeptidoglycan synthase FtsItarget
DB01150CefprozilPenicillin-binding protein 1Atarget
DB01150CefprozilPenicillin-binding protein 2xtarget
DB01150CefprozilPenicillin-binding protein 2Btarget
DB04918CeftobiproleMecAtarget
DB04918CeftobiprolePenicillin-binding protein 2xtarget
DB04918CeftobiprolePeptidoglycan synthase FtsItarget
DB01212CeftriaxoneSerum albumincarrier
DB01212CeftriaxoneSolute carrier family 15 member 1transporter
DB01212CeftriaxoneSolute carrier family 15 member 2transporter
DB01212CeftriaxoneSolute carrier family 22 member 6transporter
DB01212CeftriaxoneSolute carrier family 22 member 8transporter
DB01212CeftriaxoneSolute carrier family 22 member 11transporter
DB01212CeftriaxonePenicillin-binding protein 2Btarget
DB01212CeftriaxoneGlutamine synthetaseenzyme
DB01212CeftriaxoneSolute carrier family 22 member 11target
DB01212CeftriaxoneSolute carrier family 22 member 6target
DB01212CeftriaxoneSolute carrier family 22 member 8target
DB01212CeftriaxoneSolute carrier family 15 member 1target
DB01211Clarithromycin50S ribosomal protein L10target
DB01211ClarithromycinCytochrome P450 3A4enzyme
DB01211ClarithromycinCytochrome P450 2C19enzyme
DB01211ClarithromycinCytochrome P450 3A5enzyme
DB01211ClarithromycinCytochrome P450 3A7enzyme
DB01211ClarithromycinMultidrug resistance protein 1transporter
DB01211ClarithromycinSolute carrier family 22 member 7transporter
DB01211ClarithromycinCytochrome P450 1A2enzyme
DB01211ClarithromycinPotassium voltage-gated channel subfamily H member 2target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B1target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B3target
DB01211ClarithromycinBile salt export pumptransporter
DB01190Clindamycin50S ribosomal protein L10target
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190Clindamycin23S rRNAtarget
DB00303ErtapenemPenicillin-binding protein 2target
DB00303ErtapenemPeptidoglycan synthase FtsItarget
DB00303ErtapenemPenicillin-binding protein 1Atarget
DB00303ErtapenemD-alanyl-D-alanine carboxypeptidase DacCtarget
DB00303ErtapenemD-alanyl-D-alanine carboxypeptidase DacBtarget
DB00303ErtapenemPenicillin-binding protein 1Btarget
DB00303ErtapenemPeptidoglycan synthase FtsItarget
DB00303ErtapenemPenicillin-binding protein 2target
DB00199Erythromycin23S rRNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinMultidrug resistance protein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinCytochrome P450 1A2enzyme
DB00199ErythromycinCytochrome P450 2B6enzyme
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinSerum albumintarget
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB01155GemifloxacinDNA gyrase subunit Atarget
DB01155GemifloxacinDNA topoisomerase 4 subunit Atarget
DB01155GemifloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinMultidrug resistance protein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB00601Linezolid23S rRNAtarget
DB00601LinezolidAmine oxidase [flavin-containing] Aenzyme
DB00601LinezolidAmine oxidase [flavin-containing] Benzyme
DB00218MoxifloxacinDNA gyrase subunit Atarget
DB00218MoxifloxacinDNA topoisomerase 4 subunit Atarget
DB00218MoxifloxacinDNA topoisomerase 2-alphatarget
DB00218MoxifloxacinCytochrome P450 1A2enzyme
DB01165OfloxacinDNA gyrase subunit Atarget
DB01165OfloxacinDNA topoisomerase 4 subunit Atarget
DB01165OfloxacinDNA topoisomerase 2-alphatarget
DB01165OfloxacinCytochrome P450 1A2enzyme
DB01165OfloxacinSolute carrier family 22 member 5transporter
DB01165OfloxacinMultidrug resistance-associated protein 1transporter
DB01165OfloxacinSolute carrier family 22 member 6transporter
DB01165OfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01165OfloxacinSolute carrier family 22 member 4transporter
DB01165OfloxacinBile salt export pumptransporter
DB00713OxacillinPenicillin-binding protein 1Atarget
DB00713OxacillinSolute carrier family 15 member 1transporter
DB00713OxacillinSolute carrier family 15 member 2transporter
DB00713OxacillinPenicillin-binding protein 3target
DB00713OxacillinPenicillin-binding protein 2atarget
DB00713OxacillinPenicillin-binding protein 1Atarget
DB00713OxacillinPenicillin-binding protein 2Btarget
DB00713OxacillinPenicillin-binding protein 1btarget
DB00713OxacillinSolute carrier family 15 member 1target
DB00713OxacillinPenicillin-binding protein 2target
DB00713OxacillinSolute carrier family 15 member 2target
DB00417PhenoxymethylpenicillinPenicillin-binding protein 1Atarget
DB00417PhenoxymethylpenicillinMecA PBP2' (penicillin binding protein 2')target
DB00417PhenoxymethylpenicillinD-alanyl-D-alanine carboxypeptidase DacBtarget
DB00417PhenoxymethylpenicillinPenicillin acylasetarget
DB00417PhenoxymethylpenicillinSolute carrier family 15 member 1target
DB09324SulbactamBeta-lactamasetarget
DB00560Tigecycline30S ribosomal protein S9target
DB00560Tigecycline16S rRNAtarget
DB00560Tigecycline30S ribosomal protein S14target
DB00560Tigecycline30S ribosomal protein S13target
DB00560Tigecycline30S ribosomal protein S19target
DB00560Tigecycline30S ribosomal protein S12target
DrugDrug NamePhaseStatusCount
DB06087Friulimicin B1Terminated1
DB08816Ticagrelor1Completed1
DB01060Amoxicillin2Recruiting1
DB00766Clavulanate2Recruiting1
DB00303Ertapenem2Completed1
DB00062Human Serum Albumin2Completed1
DB01137Levofloxacin2Completed1
DB01137Levofloxacin2Terminated1
DB06600Nemonoxacin2Completed2
DB12339Radezolid2Completed1
DB12479Zabofloxacin2Terminated1
DB01060Amoxicillin2 / 3Recruiting1
DB06590Ceftaroline fosamil2 / 3Completed1
DB01212Ceftriaxone2 / 3Completed1
DB00207Azithromycin3Completed1
DB00207Azithromycin3Withdrawn1
DB12430BC-37813Completed2
DB00443Betamethasone3Not Yet Recruiting1
DB00438Ceftazidime3Recruiting1
DB01212Ceftriaxone3Recruiting1
DB06219Dalbavancin3Withdrawn1
DB11943Delafloxacin3Recruiting1
DB00303Ertapenem3Unknown Status1
DB12190Faropenem3Unknown Status1
DB00741Hydrocortisone3Recruiting1
DB01137Levofloxacin3Completed1
DB00601Linezolid3Completed1
DB00601Linezolid3Recruiting1
DB00601Linezolid3Withdrawn1
DB00218Moxifloxacin3Completed2
DB00218Moxifloxacin3Recruiting1
DB06600Nemonoxacin3Completed1
DB00635Prednisone3Completed1
DB00641Simvastatin3Unknown Status1
DB00560Tigecycline3Completed1
DB01060Amoxicillin4Completed2
DB01060Amoxicillin4Recruiting1
DB01060Amoxicillin4Terminated1
DB00415Ampicillin4Terminated1
DB00207Azithromycin4Completed1
DB00207Azithromycin4Recruiting1
DB00493Cefotaxime4Recruiting1
DB01212Ceftriaxone4Completed2
DB01212Ceftriaxone4Recruiting1
DB01112Cefuroxime4Completed1
DB00766Clavulanate4Completed1
DB01234Dexamethasone4Recruiting1
DB00741Hydrocortisone4Recruiting1
DB01137Levofloxacin4Completed2
DB01137Levofloxacin4Recruiting2
DB01137Levofloxacin4Unknown Status1
DB00959Methylprednisolone4Completed1
DB00959Methylprednisolone4Recruiting1
DB00916Metronidazole4Unknown Status1
DB00218Moxifloxacin4Not Yet Recruiting1
DB00218Moxifloxacin4Recruiting1
DB00218Moxifloxacin4Terminated1
DB00218Moxifloxacin4Unknown Status1
DB00713Oxacillin4Completed1
DB00641Simvastatin4Withdrawn1
DB09153Sodium Chloride4Completed1
DB09153Sodium Chloride4Recruiting1
DB00976Telithromycin4Completed1
DB01273Varenicline4Completed1
DB00802AlfentanilNot AvailableRecruiting1
DB01238AripiprazoleNot AvailableRecruiting1
DB00207AzithromycinNot AvailableCompleted1
DB00207AzithromycinNot AvailableNot Yet Recruiting1
DB01326CefamandoleNot AvailableNot Yet Recruiting1
DB00438CeftazidimeNot AvailableRecruiting1
DB01212CeftriaxoneNot AvailableNot Yet Recruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00501CimetidineNot AvailableCompleted1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB01234DexamethasoneNot AvailableRecruiting1
DB00829DiazepamNot AvailableRecruiting1
DB00199ErythromycinNot AvailableNot Yet Recruiting1
DB00736EsomeprazoleNot AvailableCompleted1
DB00927FamotidineNot AvailableCompleted1
DB01320FosphenytoinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB01109HeparinNot AvailableRecruiting1
DB00327HydromorphoneNot AvailableRecruiting1
DB12770LafutidineNot AvailableCompleted1
DB00448LansoprazoleNot AvailableCompleted1
DB04570LatamoxefNot AvailableNot Yet Recruiting1
DB01202LevetiracetamNot AvailableRecruiting1
DB08815LurasidoneNot AvailableRecruiting1
DB00760MeropenemNot AvailableRecruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB00683MidazolamNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00295MorphineNot AvailableRecruiting1
DB00218MoxifloxacinNot AvailableNot Yet Recruiting1
DB00622NicardipineNot AvailableRecruiting1
DB13760NiperotidineNot AvailableCompleted1
DB00585NizatidineNot AvailableCompleted1
DB00334OlanzapineNot AvailableRecruiting1
DB00338OmeprazoleNot AvailableCompleted1
DB00198OseltamivirNot AvailableRecruiting1
DB00213PantoprazoleNot AvailableCompleted1
DB00312PentobarbitalNot AvailableRecruiting1
DB00818PropofolNot AvailableRecruiting1
DB01224QuetiapineNot AvailableRecruiting1
DB01129RabeprazoleNot AvailableCompleted1
DB00863RanitidineNot AvailableCompleted1
DB00734RisperidoneNot AvailableRecruiting1
DB08806Roxatidine acetateNot AvailableCompleted1
DB09153Sodium ChlorideNot AvailableCompleted1
DB09153Sodium ChlorideNot AvailableNot Yet Recruiting1
DB00373TimololNot AvailableRecruiting1
DB00684TobramycinNot AvailableRecruiting1
DB00273TopiramateNot AvailableRecruiting1
DB00313Valproic AcidNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1