Identification
NameIndenolol
Accession NumberDB08952
TypeSmall Molecule
GroupsWithdrawn
Description

Indenolol is a drug of the beta-adrenergic blocker class.

Structure
Thumb
SynonymsNot Available
External IDs Not Available
Product Ingredients Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Categories
UNII3MZM7RWW00
CAS number60607-68-3
WeightAverage: 247.3327
Monoisotopic: 247.157228921
Chemical FormulaC15H21NO2
InChI KeyMPGBPFMOOXKQRX-UHFFFAOYSA-N
InChI
InChI=1S/C15H21NO2/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15/h3-4,6-8,11,13,16-17H,5,9-10H2,1-2H3
IUPAC Name
1-(1H-inden-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol
SMILES
CC(C)NCC(O)COC1=CC=CC2=C1C=CC2
Pharmacology
IndicationNot Available
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of actionNot Available
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,10-Phenanthroline1,10-Phenanthroline may increase the bradycardic activities of Indenolol.Experimental
4-Methoxyamphetamine4-Methoxyamphetamine may increase the atrioventricular blocking (AV block) activities of Indenolol.Experimental, Illicit
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypotensive activities of Indenolol.Experimental
AcebutololAcebutolol may increase the hypotensive activities of Indenolol.Approved
AceclofenacAceclofenac may decrease the antihypertensive activities of Indenolol.Approved
AcepromazineAcepromazine may increase the hypotensive activities of Indenolol.Approved, Vet Approved
AceprometazineAceprometazine may increase the hypotensive activities of Indenolol.Approved
AcetohexamideIndenolol may increase the hypoglycemic activities of Acetohexamide.Withdrawn
AcetylcholineThe risk or severity of adverse effects can be increased when Indenolol is combined with Acetylcholine.Approved
AcetyldigitoxinIndenolol may increase the bradycardic activities of Acetyldigitoxin.Approved
Acetylsalicylic acidAcetylsalicylic acid may decrease the antihypertensive activities of Indenolol.Approved, Vet Approved
AdapaleneAdapalene may decrease the antihypertensive activities of Indenolol.Approved
AgmatineAgmatine may increase the atrioventricular blocking (AV block) activities of Indenolol.Experimental, Investigational
AlfentanilAlfentanil may increase the bradycardic activities of Indenolol.Approved, Illicit
AlfuzosinAlfuzosin may increase the hypotensive activities of Indenolol.Approved, Investigational
AlimemazineAlimemazine may increase the hypotensive activities of Indenolol.Approved, Vet Approved
AliskirenIndenolol may increase the hypotensive activities of Aliskiren.Approved, Investigational
AlprenololAlprenolol may increase the hypotensive activities of Indenolol.Approved, Withdrawn
AmbenoniumAmbenonium may increase the bradycardic activities of Indenolol.Approved
AmbrisentanIndenolol may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmifostineIndenolol may increase the hypotensive activities of Amifostine.Approved, Investigational
AmiodaroneAmiodarone may increase the bradycardic activities of Indenolol.Approved, Investigational
AmlodipineAmlodipine may increase the hypotensive activities of Indenolol.Approved
AmobarbitalThe serum concentration of Indenolol can be decreased when it is combined with Amobarbital.Approved, Illicit
AmodiaquineThe metabolism of Indenolol can be decreased when combined with Amodiaquine.Approved
AndrographolideHMPL-004 may decrease the antihypertensive activities of Indenolol.Investigational
AntipyrineAntipyrine may decrease the antihypertensive activities of Indenolol.Approved
ApomorphineApomorphine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Investigational
ApremilastApremilast may decrease the antihypertensive activities of Indenolol.Approved, Investigational
ArecolineThe risk or severity of adverse effects can be increased when Indenolol is combined with Arecoline.Experimental
AtenololAtenolol may increase the hypotensive activities of Indenolol.Approved
AzapropazoneAzapropazone may decrease the antihypertensive activities of Indenolol.Withdrawn
AzelastineAzelastine may decrease the antihypertensive activities of Indenolol.Approved
BalsalazideBalsalazide may decrease the antihypertensive activities of Indenolol.Approved, Investigational
BarbexacloneThe serum concentration of Indenolol can be decreased when it is combined with Barbexaclone.Experimental
BarbitalThe serum concentration of Indenolol can be decreased when it is combined with Barbital.Illicit
BenazeprilBenazepril may increase the hypotensive activities of Indenolol.Approved, Investigational
BendroflumethiazideBendroflumethiazide may increase the hypotensive activities of Indenolol.Approved
BenmoxinBenmoxin may increase the hypotensive activities of Indenolol.Withdrawn
BenoxaprofenBenoxaprofen may decrease the antihypertensive activities of Indenolol.Withdrawn
BenzphetamineBenzphetamine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Illicit
BepridilBepridil may increase the hypotensive activities of Indenolol.Approved, Withdrawn
BetaxololBetaxolol may increase the hypotensive activities of Indenolol.Approved
BethanecholThe risk or severity of adverse effects can be increased when Indenolol is combined with Bethanechol.Approved
BethanidineBethanidine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
Betulinic AcidBetulinic Acid may decrease the antihypertensive activities of Indenolol.Investigational
BimatoprostBimatoprost may increase the hypotensive activities of Indenolol.Approved, Investigational
BisoprololBisoprolol may increase the hypotensive activities of Indenolol.Approved
BL-1020BL-1020 may increase the hypotensive activities of Indenolol.Investigational
BosentanBosentan may increase the hypotensive activities of Indenolol.Approved, Investigational
BretyliumBretylium may increase the hypotensive activities of Indenolol.Approved
BrimonidineBrimonidine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
BrimonidineBrimonidine may increase the antihypertensive activities of Indenolol.Approved
BromfenacBromfenac may decrease the antihypertensive activities of Indenolol.Approved
BromocriptineBromocriptine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Investigational
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Indenolol.Approved, Investigational
BupranololBupranolol may increase the hypotensive activities of Indenolol.Approved
CabergolineIndenolol may increase the vasoconstricting activities of Cabergoline.Approved
CandesartanCandesartan may increase the hypotensive activities of Indenolol.Approved
CandoxatrilCandoxatril may increase the hypotensive activities of Indenolol.Experimental
CaptoprilCaptopril may increase the hypotensive activities of Indenolol.Approved
CarbacholThe risk or severity of adverse effects can be increased when Indenolol is combined with Carbachol.Approved
CaroxazoneCaroxazone may increase the hypotensive activities of Indenolol.Withdrawn
CarprofenCarprofen may decrease the antihypertensive activities of Indenolol.Approved, Vet Approved, Withdrawn
CarteololCarteolol may increase the hypotensive activities of Indenolol.Approved
CarvedilolIndenolol may increase the orthostatic hypotensive activities of Carvedilol.Approved, Investigational
CastanospermineCastanospermine may decrease the antihypertensive activities of Indenolol.Experimental
CelecoxibCelecoxib may decrease the antihypertensive activities of Indenolol.Approved, Investigational
CeliprololCeliprolol may increase the hypotensive activities of Indenolol.Approved, Investigational
CevimelineThe risk or severity of adverse effects can be increased when Indenolol is combined with Cevimeline.Approved
ChloroquineThe metabolism of Indenolol can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorothiazideChlorothiazide may increase the hypotensive activities of Indenolol.Approved, Vet Approved
ChlorpromazineChlorpromazine may increase the hypotensive activities of Indenolol.Approved, Vet Approved
ChlorpropamideIndenolol may increase the hypoglycemic activities of Chlorpropamide.Approved
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Indenolol.Approved
Choline magnesium trisalicylateTrisalicylate-choline may decrease the antihypertensive activities of Indenolol.Approved
CilazaprilCilazapril may increase the hypotensive activities of Indenolol.Approved
ClonidineClonidine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
ClonixinClonixin may decrease the antihypertensive activities of Indenolol.Approved
CryptenamineCryptenamine may increase the hypotensive activities of Indenolol.Approved
CyclothiazideCyclothiazide may increase the hypotensive activities of Indenolol.Approved
DapoxetineThe serum concentration of Indenolol can be increased when it is combined with Dapoxetine.Investigational
DebrisoquinDebrisoquin may increase the hypotensive activities of Indenolol.Approved
DecamethoniumDecamethonium may increase the bradycardic activities of Indenolol.Approved
DemecariumDemecarium may increase the bradycardic activities of Indenolol.Approved
DeserpidineIndenolol may increase the hypotensive activities of Deserpidine.Approved
DeslanosideIndenolol may increase the bradycardic activities of Deslanoside.Approved
DesvenlafaxineThe serum concentration of Indenolol can be increased when it is combined with Desvenlafaxine.Approved
DexmedetomidineDexmedetomidine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Vet Approved
DiazoxideDiazoxide may increase the hypotensive activities of Indenolol.Approved
DiclofenacDiclofenac may decrease the antihypertensive activities of Indenolol.Approved, Vet Approved
DiflunisalDiflunisal may decrease the antihypertensive activities of Indenolol.Approved
DigitoxinIndenolol may increase the bradycardic activities of Digitoxin.Approved
DigoxinIndenolol may increase the bradycardic activities of Digoxin.Approved
DihydroergotamineDihydroergotamine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
DiltiazemDiltiazem may increase the hypotensive activities of Indenolol.Approved
DipivefrinDipivefrin may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
DipyridamoleDipyridamole may increase the bradycardic activities of Indenolol.Approved
DisopyramideDisopyramide may increase the bradycardic activities of Indenolol.Approved
DonepezilDonepezil may increase the bradycardic activities of Indenolol.Approved
DorzolamideDorzolamide may increase the hypotensive activities of Indenolol.Approved
DoxazosinIndenolol may increase the orthostatic hypotensive activities of Doxazosin.Approved
DronedaroneDronedarone may increase the bradycardic activities of Indenolol.Approved
DroxicamDroxicam may decrease the antihypertensive activities of Indenolol.Approved
DroxidopaDroxidopa may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Investigational
DuloxetineThe serum concentration of Indenolol can be increased when it is combined with Duloxetine.Approved
EchothiophateEchothiophate may increase the bradycardic activities of Indenolol.Approved
EdrophoniumEdrophonium may increase the bradycardic activities of Indenolol.Approved
EfonidipineIndenolol may increase the hypotensive activities of Efonidipine.Approved
EnalaprilEnalapril may increase the hypotensive activities of Indenolol.Approved, Vet Approved
EnalaprilatIndenolol may increase the hypotensive activities of Enalaprilat.Approved
EphedraEphedra may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Nutraceutical, Withdrawn
EPIBATIDINEThe risk or severity of adverse effects can be increased when Indenolol is combined with EPIBATIDINE.Experimental
EpinephrineEpinephrine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Vet Approved
EpirizoleEpirizole may decrease the antihypertensive activities of Indenolol.Approved
EpoprostenolEpoprostenol may increase the hypotensive activities of Indenolol.Approved
EprosartanEprosartan may increase the hypotensive activities of Indenolol.Approved
Ergoloid mesylateIndenolol may increase the vasoconstricting activities of Ergoloid mesylate.Approved
ErgonovineIndenolol may increase the vasoconstricting activities of Ergonovine.Approved
ErgotamineErgotamine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
EtanerceptEtanercept may decrease the antihypertensive activities of Indenolol.Approved, Investigational
EtodolacEtodolac may decrease the antihypertensive activities of Indenolol.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may decrease the antihypertensive activities of Indenolol.Approved
EtomidateEtomidate may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
EtoperidoneThe serum concentration of Indenolol can be increased when it is combined with Etoperidone.Approved
EtoricoxibEtoricoxib may decrease the antihypertensive activities of Indenolol.Approved, Investigational
FelodipineFelodipine may increase the hypotensive activities of Indenolol.Approved, Investigational
FenbufenFenbufen may decrease the antihypertensive activities of Indenolol.Approved
FenoldopamFenoldopam may increase the hypotensive activities of Indenolol.Approved
FenoprofenFenoprofen may decrease the antihypertensive activities of Indenolol.Approved
FentanylFentanyl may increase the bradycardic activities of Indenolol.Approved, Illicit, Investigational, Vet Approved
FingolimodIndenolol may increase the bradycardic activities of Fingolimod.Approved, Investigational
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Indenolol.Approved, Withdrawn
FluoxetineThe serum concentration of Indenolol can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FluphenazineFluphenazine may increase the hypotensive activities of Indenolol.Approved
FlurbiprofenFlurbiprofen may decrease the antihypertensive activities of Indenolol.Approved, Investigational
FosinoprilFosinopril may increase the hypotensive activities of Indenolol.Approved
FurazolidoneFurazolidone may increase the hypotensive activities of Indenolol.Approved, Vet Approved
GalantamineGalantamine may increase the bradycardic activities of Indenolol.Approved
Gallamine TriethiodideGallamine Triethiodide may increase the bradycardic activities of Indenolol.Approved
Ginkgo bilobaGinkgo biloba may increase the bradycardic activities of Indenolol.Approved, Nutraceutical
GlibornurideIndenolol may increase the hypoglycemic activities of Glibornuride.Withdrawn
GliclazideIndenolol may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideIndenolol may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideIndenolol may increase the hypoglycemic activities of Glipizide.Approved
GliquidoneIndenolol may increase the hypoglycemic activities of Gliquidone.Approved
GlisoxepideIndenolol may increase the hypoglycemic activities of Glisoxepide.Approved
GlyburideIndenolol may increase the hypoglycemic activities of Glyburide.Approved
GTS-21The risk or severity of adverse effects can be increased when Indenolol is combined with GTS-21.Investigational
GuanabenzGuanabenz may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
GuanadrelGuanadrel may increase the hypotensive activities of Indenolol.Approved
GuanethidineGuanethidine may increase the hypotensive activities of Indenolol.Approved
GuanfacineGuanfacine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Investigational
HexamethoniumIndenolol may increase the hypotensive activities of Hexamethonium.Experimental
HexobarbitalThe serum concentration of Indenolol can be decreased when it is combined with Hexobarbital.Approved
Huperzine AHuperzine A may increase the bradycardic activities of Indenolol.Investigational
HydracarbazineHydracarbazine may increase the hypotensive activities of Indenolol.Approved
HydralazineHydralazine may increase the hypotensive activities of Indenolol.Approved
HydrochlorothiazideHydrochlorothiazide may increase the hypotensive activities of Indenolol.Approved, Vet Approved
HydroflumethiazideHydroflumethiazide may increase the hypotensive activities of Indenolol.Approved
HydroxychloroquineThe metabolism of Indenolol can be decreased when combined with Hydroxychloroquine.Approved
IbuprofenIbuprofen may decrease the antihypertensive activities of Indenolol.Approved
IbuproxamIbuproxam may decrease the antihypertensive activities of Indenolol.Withdrawn
IcatibantIcatibant may decrease the antihypertensive activities of Indenolol.Approved
IloprostIloprost may increase the hypotensive activities of Indenolol.Approved, Investigational
IndalpineThe serum concentration of Indenolol can be increased when it is combined with Indalpine.Investigational, Withdrawn
IndapamideIndapamide may increase the hypotensive activities of Indenolol.Approved
IndomethacinIndomethacin may decrease the antihypertensive activities of Indenolol.Approved, Investigational
IndoprofenIndoprofen may decrease the antihypertensive activities of Indenolol.Withdrawn
IndoraminIndenolol may increase the orthostatic hypotensive activities of Indoramin.Withdrawn
Insulin PorkIndenolol may increase the hypoglycemic activities of Insulin Pork.Approved
IproclozideIproclozide may increase the hypotensive activities of Indenolol.Withdrawn
IproniazidIproniazid may increase the hypotensive activities of Indenolol.Withdrawn
IrbesartanIrbesartan may increase the hypotensive activities of Indenolol.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Indenolol.Approved
IsoflurophateIsoflurophate may increase the bradycardic activities of Indenolol.Approved, Withdrawn
IsoxicamIsoxicam may decrease the antihypertensive activities of Indenolol.Withdrawn
IsradipineIsradipine may increase the hypotensive activities of Indenolol.Approved
KebuzoneKebuzone may decrease the antihypertensive activities of Indenolol.Experimental
KetoprofenKetoprofen may decrease the antihypertensive activities of Indenolol.Approved, Vet Approved
KetorolacKetorolac may decrease the antihypertensive activities of Indenolol.Approved
LabetalolIndenolol may increase the orthostatic hypotensive activities of Labetalol.Approved
LacidipineIndenolol may increase the hypotensive activities of Lacidipine.Approved
LatanoprostLatanoprost may increase the hypotensive activities of Indenolol.Approved, Investigational
LeflunomideLeflunomide may decrease the antihypertensive activities of Indenolol.Approved, Investigational
LercanidipineLercanidipine may increase the hypotensive activities of Indenolol.Approved, Investigational
LevomilnacipranThe serum concentration of Indenolol can be increased when it is combined with Levomilnacipran.Approved
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Indenolol.Approved, Vet Approved
LisinoprilLisinopril may increase the hypotensive activities of Indenolol.Approved, Investigational
LobelineThe risk or severity of adverse effects can be increased when Indenolol is combined with Lobeline.Investigational
LofexidineLofexidine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Investigational
LornoxicamLornoxicam may decrease the antihypertensive activities of Indenolol.Approved
LosartanLosartan may increase the hypotensive activities of Indenolol.Approved
LoxoprofenLoxoprofen may decrease the antihypertensive activities of Indenolol.Approved
LumiracoxibLumiracoxib may decrease the antihypertensive activities of Indenolol.Approved, Investigational
MacitentanIndenolol may increase the hypotensive activities of Macitentan.Approved
Magnesium salicylateMagnesium salicylate may decrease the antihypertensive activities of Indenolol.Approved
MalathionMalathion may increase the bradycardic activities of Indenolol.Approved, Investigational
ManidipineIndenolol may increase the hypotensive activities of Manidipine.Approved
MasoprocolMasoprocol may decrease the antihypertensive activities of Indenolol.Approved
MebanazineMebanazine may increase the hypotensive activities of Indenolol.Withdrawn
MecamylamineMecamylamine may increase the hypotensive activities of Indenolol.Approved
Meclofenamic acidMeclofenamic acid may decrease the antihypertensive activities of Indenolol.Approved, Vet Approved
Mefenamic acidMefenamic acid may decrease the antihypertensive activities of Indenolol.Approved
MefloquineMefloquine may increase the bradycardic activities of Indenolol.Approved
MeloxicamMeloxicam may decrease the antihypertensive activities of Indenolol.Approved, Vet Approved
MemantineMemantine may increase the bradycardic activities of Indenolol.Approved, Investigational
MepivacaineThe serum concentration of Mepivacaine can be increased when it is combined with Indenolol.Approved, Vet Approved
MesalazineMesalazine may decrease the antihypertensive activities of Indenolol.Approved
MesoridazineMesoridazine may increase the hypotensive activities of Indenolol.Approved
MetamizoleMetamizole may decrease the antihypertensive activities of Indenolol.Withdrawn
MethacholineThe risk or severity of adverse effects can be increased when Indenolol is combined with Methacholine.Approved
MethamphetamineMethamphetamine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Illicit
MethohexitalThe serum concentration of Indenolol can be decreased when it is combined with Methohexital.Approved
MethotrimeprazineMethotrimeprazine may increase the hypotensive activities of Indenolol.Approved
MethyldopaMethyldopa may increase the hypotensive activities of Indenolol.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Indenolol.Investigational
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Indenolol.Approved, Investigational
MethylphenobarbitalThe serum concentration of Indenolol can be decreased when it is combined with Methylphenobarbital.Approved
MetipranololMetipranolol may increase the hypotensive activities of Indenolol.Approved
MetolazoneMetolazone may increase the hypotensive activities of Indenolol.Approved
MetoprololMetoprolol may increase the hypotensive activities of Indenolol.Approved, Investigational
MetyrosineIndenolol may increase the hypotensive activities of Metyrosine.Approved
MibefradilMibefradil may increase the hypotensive activities of Indenolol.Withdrawn
MidodrineIndenolol may increase the bradycardic activities of Midodrine.Approved
MilnacipranThe serum concentration of Indenolol can be increased when it is combined with Milnacipran.Approved
MinaprineMinaprine may increase the bradycardic activities of Indenolol.Approved
MinoxidilMinoxidil may increase the hypotensive activities of Indenolol.Approved
MoclobemideMoclobemide may increase the hypotensive activities of Indenolol.Approved
MoexiprilMoexipril may increase the hypotensive activities of Indenolol.Approved
MolsidomineMolsidomine may increase the hypotensive activities of Indenolol.Approved
MoricizineMoricizine may increase the hypotensive activities of Indenolol.Approved, Withdrawn
MoxonidineIndenolol may increase the hypotensive activities of Moxonidine.Approved
Mycophenolate mofetilMycophenolate mofetil may decrease the antihypertensive activities of Indenolol.Approved, Investigational
Mycophenolic acidMycophenolic acid may decrease the antihypertensive activities of Indenolol.Approved
NabumetoneNabumetone may decrease the antihypertensive activities of Indenolol.Approved
NadololNadolol may increase the hypotensive activities of Indenolol.Approved
NafamostatNafamostat may decrease the antihypertensive activities of Indenolol.Approved, Investigational
NaftifineNaftifine may decrease the antihypertensive activities of Indenolol.Approved
NaphazolineNaphazoline may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
NaproxenNaproxen may decrease the antihypertensive activities of Indenolol.Approved, Vet Approved
NCX 4016NCX 4016 may decrease the antihypertensive activities of Indenolol.Investigational
NebivololNebivolol may increase the hypotensive activities of Indenolol.Approved, Investigational
NefazodoneThe serum concentration of Indenolol can be increased when it is combined with Nefazodone.Approved, Withdrawn
NeostigmineNeostigmine may increase the bradycardic activities of Indenolol.Approved, Vet Approved
NepafenacNepafenac may decrease the antihypertensive activities of Indenolol.Approved
NialamideNialamide may increase the hypotensive activities of Indenolol.Withdrawn
NicardipineNicardipine may increase the hypotensive activities of Indenolol.Approved
NicorandilIndenolol may increase the hypotensive activities of Nicorandil.Approved
NicotineThe risk or severity of adverse effects can be increased when Indenolol is combined with Nicotine.Approved
NifedipineNifedipine may increase the hypotensive activities of Indenolol.Approved
Niflumic AcidNiflumic Acid may decrease the antihypertensive activities of Indenolol.Approved
NiguldipineIndenolol may increase the hypotensive activities of Niguldipine.Experimental
NilvadipineNilvadipine may increase the hypotensive activities of Indenolol.Approved
NimesulideNimesulide may decrease the antihypertensive activities of Indenolol.Approved, Withdrawn
NimodipineNimodipine may increase the hypotensive activities of Indenolol.Approved
NisoldipineNisoldipine may increase the hypotensive activities of Indenolol.Approved
NitrendipineNitrendipine may increase the hypotensive activities of Indenolol.Approved
NitroprussideNitroprusside may increase the hypotensive activities of Indenolol.Approved
NorepinephrineNorepinephrine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
ObinutuzumabIndenolol may increase the hypotensive activities of Obinutuzumab.Approved
OctamoxinOctamoxin may increase the hypotensive activities of Indenolol.Withdrawn
OleandrinIndenolol may increase the bradycardic activities of Anvirzel.Experimental
OlmesartanOlmesartan may increase the hypotensive activities of Indenolol.Approved, Investigational
OlopatadineOlopatadine may decrease the antihypertensive activities of Indenolol.Approved
OlsalazineOlsalazine may decrease the antihypertensive activities of Indenolol.Approved
OmapatrilatOmapatrilat may increase the hypotensive activities of Indenolol.Investigational
OuabainIndenolol may increase the bradycardic activities of Ouabain.Approved
OxaprozinOxaprozin may decrease the antihypertensive activities of Indenolol.Approved
OxprenololOxprenolol may increase the hypotensive activities of Indenolol.Approved
OxymetazolineOxymetazoline may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
OxyphenbutazoneOxyphenbutazone may decrease the antihypertensive activities of Indenolol.Withdrawn
PaliperidonePaliperidone may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
ParecoxibParecoxib may decrease the antihypertensive activities of Indenolol.Approved
PargylinePargyline may increase the hypotensive activities of Indenolol.Approved
ParoxetineThe serum concentration of Indenolol can be increased when it is combined with Paroxetine.Approved, Investigational
PenbutololPenbutolol may increase the hypotensive activities of Indenolol.Approved, Investigational
PentobarbitalThe serum concentration of Indenolol can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PentoliniumPentolinium may increase the hypotensive activities of Indenolol.Approved
PentoxifyllinePentoxifylline may increase the hypotensive activities of Indenolol.Approved, Investigational
PergolidePergolide may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Vet Approved, Withdrawn
PerindoprilPerindopril may increase the hypotensive activities of Indenolol.Approved
PerphenazinePerphenazine may increase the hypotensive activities of Indenolol.Approved
PhenelzinePhenelzine may increase the hypotensive activities of Indenolol.Approved
PheniprazinePheniprazine may increase the hypotensive activities of Indenolol.Withdrawn
PhenobarbitalThe serum concentration of Indenolol can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzaminePhenoxybenzamine may increase the hypotensive activities of Indenolol.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Indenolol.Withdrawn
PhentolaminePhentolamine may increase the hypotensive activities of Indenolol.Approved
PhenylbutazonePhenylbutazone may decrease the antihypertensive activities of Indenolol.Approved, Vet Approved
PhenylpropanolaminePhenylpropanolamine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Vet Approved, Withdrawn
PhysostigminePhysostigmine may increase the bradycardic activities of Indenolol.Approved
PilocarpineThe risk or severity of adverse effects can be increased when Indenolol is combined with Pilocarpine.Approved
PimecrolimusPimecrolimus may decrease the antihypertensive activities of Indenolol.Approved, Investigational
PindololPindolol may increase the hypotensive activities of Indenolol.Approved
PirfenidonePirfenidone may decrease the antihypertensive activities of Indenolol.Investigational
PirlindolePirlindole may increase the hypotensive activities of Indenolol.Approved
PiroxicamPiroxicam may decrease the antihypertensive activities of Indenolol.Approved, Investigational
PivhydrazinePivhydrazine may increase the hypotensive activities of Indenolol.Withdrawn
PolythiazidePolythiazide may increase the hypotensive activities of Indenolol.Approved
PrazosinIndenolol may increase the orthostatic hypotensive activities of Prazosin.Approved
PrimaquineThe metabolism of Indenolol can be decreased when combined with Primaquine.Approved
PrimidoneThe serum concentration of Indenolol can be decreased when it is combined with Primidone.Approved, Vet Approved
ProchlorperazineProchlorperazine may increase the hypotensive activities of Indenolol.Approved, Vet Approved
PromazinePromazine may increase the hypotensive activities of Indenolol.Approved, Vet Approved
PromethazinePromethazine may increase the hypotensive activities of Indenolol.Approved
PropacetamolPropacetamol may decrease the antihypertensive activities of Indenolol.Approved
PropafenoneThe serum concentration of Indenolol can be increased when it is combined with Propafenone.Approved
PropranololPropranolol may increase the hypotensive activities of Indenolol.Approved, Investigational
PseudoephedrinePseudoephedrine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
PTC299PTC299 may decrease the antihypertensive activities of Indenolol.Investigational
PyridostigminePyridostigmine may increase the bradycardic activities of Indenolol.Approved
QuinaprilQuinapril may increase the hypotensive activities of Indenolol.Approved, Investigational
QuinineQuinine may increase the hypotensive activities of Indenolol.Approved
RamiprilRamipril may increase the hypotensive activities of Indenolol.Approved
RasagilineRasagiline may increase the hypotensive activities of Indenolol.Approved
RegorafenibRegorafenib may increase the bradycardic activities of Indenolol.Approved
RemifentanilRemifentanil may increase the bradycardic activities of Indenolol.Approved
RemikirenRemikiren may increase the hypotensive activities of Indenolol.Approved
RescinnamineIndenolol may increase the hypotensive activities of Rescinnamine.Approved
ReserpineReserpine may increase the hypotensive activities of Indenolol.Approved
ResveratrolResveratrol may decrease the antihypertensive activities of Indenolol.Experimental, Investigational
RifampicinThe serum concentration of Indenolol can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Indenolol can be decreased when it is combined with Rifapentine.Approved
RiociguatIndenolol may increase the hypotensive activities of Riociguat.Approved
RisperidoneRisperidone may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Investigational
RituximabIndenolol may increase the hypotensive activities of Rituximab.Approved
RivastigmineRivastigmine may increase the bradycardic activities of Indenolol.Approved, Investigational
RofecoxibRofecoxib may decrease the antihypertensive activities of Indenolol.Investigational, Withdrawn
RopiniroleRopinirole may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved, Investigational
SafrazineSafrazine may increase the hypotensive activities of Indenolol.Withdrawn
SalicylamideSalicylamide may decrease the antihypertensive activities of Indenolol.Approved
Salicylic acidSalicylic acid may decrease the antihypertensive activities of Indenolol.Approved, Vet Approved
SalsalateSalsalate may decrease the antihypertensive activities of Indenolol.Approved
SaprisartanSaprisartan may increase the hypotensive activities of Indenolol.Experimental
SecobarbitalThe serum concentration of Indenolol can be decreased when it is combined with Secobarbital.Approved, Vet Approved
SelegilineSelegiline may increase the hypotensive activities of Indenolol.Approved, Investigational, Vet Approved
SelexipagIndenolol may increase the hypotensive activities of Selexipag.Approved
SertralineThe serum concentration of Indenolol can be increased when it is combined with Sertraline.Approved
SildenafilSildenafil may increase the antihypertensive activities of Indenolol.Approved, Investigational
SilodosinIndenolol may increase the orthostatic hypotensive activities of Silodosin.Approved
SitaxentanIndenolol may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SpiraprilSpirapril may increase the hypotensive activities of Indenolol.Approved
SRT501SRT501 may decrease the antihypertensive activities of Indenolol.Investigational
SufentanilSufentanil may increase the bradycardic activities of Indenolol.Approved, Investigational
SulfasalazineSulfasalazine may decrease the antihypertensive activities of Indenolol.Approved
SulindacSulindac may decrease the antihypertensive activities of Indenolol.Approved
SuprofenSuprofen may decrease the antihypertensive activities of Indenolol.Approved, Withdrawn
TacrineTacrine may increase the bradycardic activities of Indenolol.Withdrawn
TadalafilTadalafil may increase the antihypertensive activities of Indenolol.Approved, Investigational
TamsulosinIndenolol may increase the orthostatic hypotensive activities of Tamsulosin.Approved, Investigational
TelmisartanTelmisartan may increase the hypotensive activities of Indenolol.Approved, Investigational
TemocaprilTemocapril may increase the hypotensive activities of Indenolol.Experimental, Investigational
TenoxicamTenoxicam may decrease the antihypertensive activities of Indenolol.Approved
TerazosinIndenolol may increase the orthostatic hypotensive activities of Terazosin.Approved
TeriflunomideTeriflunomide may decrease the antihypertensive activities of Indenolol.Approved
TerlipressinTerlipressin may increase the hypotensive activities of Indenolol.Approved, Investigational
ThiamylalThe serum concentration of Indenolol can be decreased when it is combined with Thiamylal.Approved, Vet Approved
ThiethylperazineThiethylperazine may increase the hypotensive activities of Indenolol.Withdrawn
ThiopentalThe serum concentration of Indenolol can be decreased when it is combined with Thiopental.Approved, Vet Approved
ThioridazineThioridazine may increase the hypotensive activities of Indenolol.Withdrawn
Tiaprofenic acidTiaprofenic acid may decrease the antihypertensive activities of Indenolol.Approved
TiboloneIndenolol may increase the hypotensive activities of Tibolone.Approved
TicrynafenTicrynafen may increase the hypotensive activities of Indenolol.Withdrawn
TimololTimolol may increase the hypotensive activities of Indenolol.Approved
TizanidineTizanidine may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
TolazamideIndenolol may increase the hypoglycemic activities of Tolazamide.Approved
TolazolineTolazoline may increase the hypotensive activities of Indenolol.Approved, Vet Approved
TolbutamideIndenolol may increase the hypoglycemic activities of Tolbutamide.Approved
Tolfenamic AcidTolfenamic Acid may decrease the antihypertensive activities of Indenolol.Approved
TolmetinTolmetin may decrease the antihypertensive activities of Indenolol.Approved
ToloxatoneToloxatone may increase the hypotensive activities of Indenolol.Approved
TorasemideTorasemide may increase the hypotensive activities of Indenolol.Approved
TrandolaprilTrandolapril may increase the hypotensive activities of Indenolol.Approved
TranilastTranilast may decrease the antihypertensive activities of Indenolol.Approved, Investigational
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Indenolol.Experimental
TranylcypromineTranylcypromine may increase the hypotensive activities of Indenolol.Approved
TravoprostTravoprost may increase the hypotensive activities of Indenolol.Approved
TreprostinilTreprostinil may increase the hypotensive activities of Indenolol.Approved, Investigational
TrichlormethiazideTrichlormethiazide may increase the hypotensive activities of Indenolol.Approved, Vet Approved
TrifluoperazineTrifluoperazine may increase the hypotensive activities of Indenolol.Approved
TriflupromazineTriflupromazine may increase the hypotensive activities of Indenolol.Approved, Vet Approved
TrimazosinIndenolol may increase the orthostatic hypotensive activities of Trimazosin.Experimental
TrimethaphanTrimethaphan may increase the hypotensive activities of Indenolol.Approved
TubocurarineTubocurarine may increase the bradycardic activities of Indenolol.Approved
UdenafilUdenafil may increase the antihypertensive activities of Indenolol.Approved, Investigational
UnoprostoneUnoprostone may increase the hypotensive activities of Indenolol.Approved
ValdecoxibValdecoxib may decrease the antihypertensive activities of Indenolol.Investigational, Withdrawn
ValsartanValsartan may increase the hypotensive activities of Indenolol.Approved, Investigational
VardenafilVardenafil may increase the antihypertensive activities of Indenolol.Approved
VareniclineThe risk or severity of adverse effects can be increased when Indenolol is combined with Varenicline.Approved, Investigational
VenlafaxineThe serum concentration of Indenolol can be increased when it is combined with Venlafaxine.Approved
VerapamilVerapamil may increase the hypotensive activities of Indenolol.Approved
XylometazolineXylometazoline may increase the atrioventricular blocking (AV block) activities of Indenolol.Approved
YohimbineYohimbine may decrease the antihypertensive activities of Indenolol.Approved, Vet Approved
ZaltoprofenZaltoprofen may decrease the antihypertensive activities of Indenolol.Approved
ZileutonZileuton may decrease the antihypertensive activities of Indenolol.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Indenolol can be increased when it is combined with Zimelidine.Withdrawn
ZomepiracZomepirac may decrease the antihypertensive activities of Indenolol.Withdrawn
Food InteractionsNot Available
References
Synthesis Reference

U.S. Patent 4,045,482.

General References
  1. Ali I, Gaitonde VD, Aboul-Enein HY, Hussain A: Chiral separation of beta-adrenergic blockers on CelluCoat column by HPLC. Talanta. 2009 Apr 30;78(2):458-63. doi: 10.1016/j.talanta.2008.11.043. Epub 2008 Dec 6. [PubMed:19203609 ]
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Clinical Trials
Clinical Trials Not Available
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)147-148U.S. Patent 4,045,482.
Predicted Properties
PropertyValueSource
Water Solubility0.277 mg/mLALOGPS
logP2.53ALOGPS
logP2.32ChemAxon
logS-3ALOGPS
pKa (Strongest Acidic)14.09ChemAxon
pKa (Strongest Basic)9.67ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area41.49 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity74.37 m3·mol-1ChemAxon
Polarizability28.66 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET featuresNot Available
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as indenes and isoindenes. These are compounds containing an indene moiety(which consists of a cyclopentadiene fused to a benzene ring), or a isoindene moiety (which consists of a cyclopentadiene fused to cyclohexadiene ring).
KingdomChemical entities
Super ClassOrganic compounds
ClassBenzenoids
Sub ClassIndenes and isoindenes
Direct ParentIndenes and isoindenes
Alternative ParentsAlkyl aryl ethers / Secondary alcohols / 1,2-aminoalcohols / Dialkylamines / Organopnictogen compounds / Hydrocarbon derivatives
SubstituentsIndene / Alkyl aryl ether / 1,2-aminoalcohol / Secondary alcohol / Secondary aliphatic amine / Ether / Secondary amine / Organic nitrogen compound / Organonitrogen compound / Organooxygen compound
Molecular FrameworkAromatic homopolycyclic compounds
External DescriptorsNot Available
Drug created on May 27, 2014 13:44 / Updated on June 11, 2017 21:21