Brotizolam

Identification

Name
Brotizolam
Accession Number
DB09017
Type
Small Molecule
Groups
Approved, Withdrawn
Description

Brotizolam is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, and is considered to be similar in effect to short-acting benzodiazepines such as triazolam. It is used in the short term treatment of severe or debilitating insomnia. Brotizolam is an extremely potent drug and it is rapidly eliminated with an average half-life of 4.4 hours (range 3.6 - 7.9 hours).

Brotizolam is not approved for sale in the UK, United States or Canada. It is approved for sale in the Netherlands, Germany, Spain, Belgium, Austria, Portugal, Israel, Italy and Japan.

Structure
Thumb
Synonyms
  • Brotizolam
  • Brotizolamum
External IDs
SID144207150 / WE 941 / WE 941-BS / WE-941 / WE-941-BS
International/Other Brands
Amnezon (Nisshin Seiyaku) / Bondormin (Rafa) / Brometon (Mylan Seiyaku) / Brotizolam M (Sannova) / Dormex (Recalcine) / Eurimolan (Choseido Pharmaceutical) / Goodmin (Tanabe Mitsubishi Pharma) / Lendorm (Boehringer Ingelheim) / Lendormin (Boehringer Ingelheim) / Lindormin (Boehringer Ingelheim) / Nestrom (Tatsumi Kagaku) / Noctilan (Boehringer Ingelheim) / Noxtal (Alfresa Pharma) / Ronfleman (Kyowa Yakuhin) / Sintonal (Europharma) / Sorentmin (Taisho Yakuhin) / Zestromin (Towa Yakuhin)
Categories
UNII
5XZM1R3DKF
CAS number
57801-81-7
Weight
Average: 393.689
Monoisotopic: 391.949807384
Chemical Formula
C15H10BrClN4S
InChI Key
UMSGKTJDUHERQW-UHFFFAOYSA-N
InChI
InChI=1S/C15H10BrClN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3
IUPAC Name
4-bromo-7-(2-chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0²,⁶]trideca-2(6),4,7,10,12-pentaene
SMILES
CC1=NN=C2CN=C(C3=C(SC(Br)=C3)N12)C1=CC=CC=C1Cl

Pharmacology

Indication

Brotizolam is indicated for the short-term treatment (2-4 weeks) of severe or debilitating insomnia.

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption

The plasma concentration profile of brotizolam can be described as a one compartmental open model with first-order absorption.

Volume of distribution

0.63 l/kg.

Protein binding

The mean value of the free fraction (%): 8.4 ± 0.7.

Metabolism

There are two primary metabolites: 1-methyl-hydroxy- and the 4-hydroxy-derivatives (Eberts et al., 1981; Boehringer Ingelheim, product information). The 4-hydroxymetabolites have a pharmacological activity which is far less than that of the parent drugs, but the 1-methyl-hydroxymetabolites probably have comparable activity (Gall et al., 1978; Jochemsen et al., 1982; Sethy & Harris, 1982; Jochemsen et al., unpublished results). These active compounds are, however, not present in plasma in measurable amounts following a single dose of brotizolam to young healthy subjects (Jochemsen et al., 1982; Jochemsen et al., unpublished results).

Route of elimination
Not Available
Half life

4.4 hours.

Clearance

Total clearance: 109 ml/min.

Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Brotizolam.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Brotizolam.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Brotizolam.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Brotizolam.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Brotizolam.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Brotizolam is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Brotizolam.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Brotizolam.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Brotizolam.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Brotizolam.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Brotizolam.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Brotizolam.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Brotizolam.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Brotizolam.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Brotizolam.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Azaperone.Vet Approved
AzelastineBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Brotizolam is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Brotizolam.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Brotizolam is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Brotizolam.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Brotizolam.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Brotizolam is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Brotizolam.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Brotizolam is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Brotizolam is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Brompheniramine.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Brotizolam.Approved, Investigational
BuprenorphineBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Brotizolam.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Brotizolam.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Brotizolam is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Brotizolam is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Brotizolam.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Brotizolam.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with Brotizolam.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Brotizolam.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brotizolam.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Brotizolam is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Brotizolam.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Brotizolam.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Brotizolam.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Brotizolam.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Brotizolam.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Brotizolam.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Brotizolam.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Brotizolam is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Brotizolam.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clonidine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Brotizolam.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clothiapine.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Brotizolam.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Brotizolam.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Brotizolam.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Brotizolam.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Brotizolam.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Dapoxetine.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Brotizolam.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Brotizolam.Approved
DesipramineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Brotizolam.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Brotizolam.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Brotizolam.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Brotizolam.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Brotizolam.Approved, Illicit, Vet Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Brotizolam is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Brotizolam is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Brotizolam.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Brotizolam.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Brotizolam.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Brotizolam is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Brotizolam.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Brotizolam.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Brotizolam is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Brotizolam is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Brotizolam.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Brotizolam.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Brotizolam.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Brotizolam.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Brotizolam is combined with Efavirenz.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Eltanolone.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Brotizolam.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Brotizolam is combined with Entacapone.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Brotizolam is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Brotizolam.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Brotizolam.Approved
EthanolBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Brotizolam.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Brotizolam is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Brotizolam.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Ethyl chloride.Experimental
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Brotizolam.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Brotizolam.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Brotizolam.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Brotizolam.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Brotizolam.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Brotizolam.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Brotizolam is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Brotizolam.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Brotizolam.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Brotizolam is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Brotizolam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Brotizolam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Brotizolam.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Brotizolam.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Brotizolam.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Brotizolam.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Brotizolam is combined with Fluticasone propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Brotizolam.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Brotizolam is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Brotizolam.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Brotizolam.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Brotizolam is combined with Gabapentin Enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Brotizolam.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Brotizolam is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brotizolam.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Brotizolam.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Brotizolam.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Brotizolam.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Brotizolam.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Brotizolam.Approved
HydrocodoneBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Brotizolam.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Indalpine.Investigational, Withdrawn
IndiplonThe risk or severity of adverse effects can be increased when Brotizolam is combined with Indiplon.Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Brotizolam.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Brotizolam.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Brotizolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Brotizolam.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Brotizolam.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Brotizolam is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Brotizolam.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Brotizolam is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Brotizolam.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Brotizolam.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Brotizolam.Approved
LofentanilThe risk or severity of adverse effects can be increased when Brotizolam is combined with Lofentanil.Illicit
LoprazolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Brotizolam.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Lormetazepam.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Brotizolam.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Brotizolam.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Maprotiline.Approved
MebicarThe risk or severity of adverse effects can be increased when Brotizolam is combined with Mebicar.Experimental
MeclizineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Brotizolam.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Brotizolam.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Brotizolam.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Brotizolam is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Brotizolam.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Brotizolam.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Brotizolam.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Brotizolam.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Brotizolam.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Brotizolam is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Brotizolam.Approved
MethotrimeprazineBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Brotizolam.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Methsuximide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Brotizolam.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Brotizolam.Approved
MetyrosineBrotizolam may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Brotizolam.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Brotizolam is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved, Investigational
MirtazapineBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Brotizolam.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Brotizolam.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Brotizolam.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Brotizolam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Brotizolam.Approved, Vet Approved
NorfluraneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Norflurane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Brotizolam.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Brotizolam.Approved
OpiumThe risk or severity of adverse effects can be increased when Brotizolam is combined with Opium.Approved, Illicit
OrphenadrineBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Brotizolam.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Brotizolam.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Oxethazaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Brotizolam.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Brotizolam.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Brotizolam.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Brotizolam.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Brotizolam.Approved
ParaldehydeBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Paroxetine.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Brotizolam is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Brotizolam.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Brotizolam.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved
PerazineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Brotizolam.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Brotizolam.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Brotizolam.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Phenazocine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Brotizolam is combined with Phenibut.Experimental
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Brotizolam.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Brotizolam is combined with Phenoxyethanol.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Brotizolam is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Brotizolam.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Brotizolam is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Pomalidomide.Approved
PramipexoleBrotizolam may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Brotizolam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brotizolam.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Brotizolam.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Brotizolam.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Brotizolam.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Brotizolam.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Promethazine.Approved
PropanididThe risk or severity of adverse effects can be increased when Brotizolam is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Brotizolam.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Brotizolam.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Brotizolam is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Brotizolam.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Brotizolam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Brotizolam.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Brotizolam is combined with Ramelteon.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Brotizolam.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Brotizolam.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Brotizolam.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Brotizolam.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Brotizolam is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Romifidine.Vet Approved
RopiniroleBrotizolam may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Brotizolam.Approved
RotigotineBrotizolam may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Brotizolam.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Brotizolam.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Brotizolam.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Brotizolam.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved
StiripentolThe risk or severity of adverse effects can be increased when Brotizolam is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Brotizolam.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Brotizolam.Approved
SultoprideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Sultopride.Experimental
SuvorexantBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Brotizolam.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Brotizolam.Investigational
ThalidomideBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Brotizolam.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Brotizolam.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Brotizolam.Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Brotizolam.Approved
TiagabineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tiapride.Approved, Investigational
TiletamineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tilidine.Experimental
TizanidineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Brotizolam is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Brotizolam.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Brotizolam.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Brotizolam.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Brotizolam.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Brotizolam.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Brotizolam is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Brotizolam is combined with Trichloroethylene.Experimental
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Brotizolam.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Brotizolam is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Brotizolam.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Triprolidine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Brotizolam.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Brotizolam is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Brotizolam is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Vortioxetine.Approved
XenonThe risk or severity of adverse effects can be increased when Brotizolam is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Brotizolam.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Brotizolam.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Zolazepam.Vet Approved
ZolpidemBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Brotizolam is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Brotizolam.Approved
ZotepineThe risk or severity of adverse effects can be increased when Brotizolam is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Brotizolam.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Brotizolam synthesis: Weber, K. H.; Bauer, A.; Danneberg, P.; Kuhn, F. J.; 1978, U.S. Patent 4,094,984.

General References
  1. Jochemsen R, Wesselman JG, van Boxtel CJ, Hermans J, Breimer DD: Comparative pharmacokinetics of brotizolam and triazolam in healthy subjects. Br J Clin Pharmacol. 1983;16 Suppl 2:291S-297S. [PubMed:6140948]
External Links
KEGG Drug
D01744
PubChem Compound
2451
PubChem Substance
310264974
ChemSpider
2357
BindingDB
50011875
ChEBI
31308
ChEMBL
CHEMBL32479
Drugs.com
Drugs.com Drug Page
Wikipedia
Brotizolam
ATC Codes
N05CD09 — Brotizolam
MSDS
Download (316 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentHealthy Volunteers3
3CompletedTreatmentSleep Initiation and Maintenance Disorders1
3Not Yet RecruitingPreventionSleeplessness1
3RecruitingTreatmentAnxiety Disorders / Dementias / Depressive State / Psychosomatic Disorders / Schizophrenic Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US4094984No1974-03-021994-03-02Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)211-213U.S. Patent 4,094,984.
Predicted Properties
PropertyValueSource
Water Solubility0.058 mg/mLALOGPS
logP3.28ALOGPS
logP2.68ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)18.49ChemAxon
pKa (Strongest Basic)3.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area43.07 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity101.93 m3·mol-1ChemAxon
Polarizability34.99 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
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Spectra
SpectrumSpectrum TypeSplash Key
Mass Spectrum (Electron Ionization)MSsplash10-0006-6559000000-7456ba6570cdfa674b63
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as thienodiazepines. These are heteropolycyclic containing a thiophene ring fused to a diazepine ring. Thiophene is 5-membered ring consisting of four carbon and one sulfur atoms. Diazepine is a 7-membered ring consisting of five carbon and two nitrogen atoms.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Thienodiazepines
Sub Class
Not Available
Direct Parent
Thienodiazepines
Alternative Parents
2,3,5-trisubstituted thiophenes / Chlorobenzenes / 1,4-diazepines / Aryl chlorides / Aryl bromides / Triazoles / Heteroaromatic compounds / Ketimines / Propargyl-type 1,3-dipolar organic compounds / Azacyclic compounds
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Substituents
Thieno-para-diazepine / 2,3,5-trisubstituted thiophene / Para-diazepine / Chlorobenzene / Halobenzene / Aryl bromide / Aryl chloride / Aryl halide / Monocyclic benzene moiety / Benzenoid
show 17 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on June 23, 2014 14:43 / Updated on October 02, 2017 06:12