Allogeneic peripheral haematopoietic stem cell transplant

Also known as: ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION / Autologous hematopoietic stem cell transplant / Allogeneic peripheral hematopoietic stem cell transplant / Allogeneic HSCT / Stem Cell Transplantation / Stem cell transplant

DrugDrug NameDrug Description
DB00563MethotrexateMethotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis.[A180322] This inhibition leads to suppression of inflammation as well as prevention of cell division.[A180322] Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments.[L7180] Methotrexate was granted FDA approval on 7 December 1953.[L7198]
DrugDrug NameTargetType
DB00563MethotrexateDihydrofolate reductasetarget
DB00563MethotrexateAldehyde oxidaseenzyme
DB00563MethotrexateMethylenetetrahydrofolate reductaseenzyme
DB00563MethotrexateSerum albumincarrier
DB00563MethotrexateCanalicular multispecific organic anion transporter 2transporter
DB00563MethotrexateMultidrug resistance-associated protein 4transporter
DB00563MethotrexateMultidrug resistance-associated protein 1transporter
DB00563MethotrexateSolute carrier family 22 member 6transporter
DB00563MethotrexateMultidrug resistance-associated protein 7transporter
DB00563MethotrexateSolute carrier family 22 member 8transporter
DB00563MethotrexateCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateP-glycoprotein 1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1A2transporter
DB00563MethotrexateMonocarboxylate transporter 1transporter
DB00563MethotrexateATP-binding cassette sub-family C member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B3transporter
DB00563MethotrexateSolute carrier family 22 member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1C1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 3A1transporter
DB00563MethotrexateATP-binding cassette sub-family G member 2transporter
DB00563MethotrexateSolute carrier family 22 member 7transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B1transporter
DB00563Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00563MethotrexateProton-coupled folate transportertransporter
DB00563MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
DB00563MethotrexateGamma-glutamyl hydrolaseenzyme
DB00563MethotrexateDihydrofolate reductaseenzyme
DB00563MethotrexateThymidylate synthaseenzyme
DB00563MethotrexateBifunctional purine biosynthesis protein PURHenzyme
DB00563MethotrexateSolute carrier organic anion transporter family member 4C1transporter
DB00563MethotrexateFolate transporter 1transporter
DB00563MethotrexateFolate receptor alphatransporter
DB00563MethotrexateCytochrome P450 3A4enzyme
DB00563MethotrexateThymidylate synthasetarget
DB00563MethotrexateBifunctional purine biosynthesis protein PURHtarget
DB00563MethotrexateFolate receptor betatransporter
DB00563MethotrexateSolute carrier family 15 member 1transporter
DB00563MethotrexateProton-coupled amino acid transporter 1transporter
DrugDrug NamePhaseStatusCount
DB00087Alemtuzumab0Terminated1
DB00091Cyclosporine0Terminated1
DB00773Etoposide0Terminated1
DB01073Fludarabine0Terminated1
DB01042Melphalan0Terminated1
DB00688Mycophenolate mofetil0Terminated1
DB01024Mycophenolic acid0Terminated1
DB00039Palifermin0Terminated1
DB00864Tacrolimus0Terminated1
DB04572Thiotepa0Terminated1
DB09033Vedolizumab1Completed1
DB09033Vedolizumab2Terminated1
DB01008Busulfan2 / 3Recruiting4
DB00531Cyclophosphamide2 / 3Recruiting3
DB01262Decitabine2 / 3Recruiting3
DB00099Filgrastim2 / 3Recruiting1
DB01073Fludarabine2 / 3Recruiting1
DB00135Tyrosine2 / 3Recruiting1
DB06534Thrombopoietin4Recruiting1
DB06210EltrombopagNot AvailableNot Yet Recruiting1