Beta-3 adrenergic receptor

Details

Name
Beta-3 adrenergic receptor
Synonyms
  • ADRB3R
  • B3AR
  • Beta-3 adrenoceptor
  • Beta-3 adrenoreceptor
Gene Name
ADRB3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0010709|Beta-3 adrenergic receptor
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Number of residues
408
Molecular Weight
43518.615
Theoretical pI
9.07
GO Classification
Functions
beta-adrenergic receptor activity / beta3-adrenergic receptor activity / epinephrine binding / norepinephrine binding / protein homodimerization activity
Processes
activation of adenylate cyclase activity / adenylate cyclase-activating adrenergic receptor signaling pathway / adenylate cyclase-modulating G-protein coupled receptor signaling pathway / aging / brown fat cell differentiation / carbohydrate metabolic process / cell-cell signaling / diet induced thermogenesis / eating behavior / energy reserve metabolic process / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / generation of precursor metabolites and energy / heat generation / negative regulation of multicellular organism growth / positive regulation of MAPK cascade / response to antibiotic / response to cold / temperature homeostasis / vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
Components
integral component of plasma membrane / nucleus / plasma membrane / receptor complex
General Function
Protein homodimerization activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Pfam Domain Function
Transmembrane Regions
37-63 73-91 112-133 156-178 204-225 293-314 327-347
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010710|Beta-3 adrenergic receptor (ADRB3)
ATGGCTCCGTGGCCTCACGAGAACAGCTCTCTTGCCCCATGGCCGGACCTCCCCACCCTG
GCGCCCAATACCGCCAACACCAGTGGGCTGCCAGGGGTTCCGTGGGAGGCGGCCCTAGCC
GGGGCCCTGCTGGCGCTGGCGGTGCTGGCCACCGTGGGAGGCAACCTGCTGGTCATCGTG
GCCATCGCCTGGACTCCGAGACTCCAGACCATGACCAACGTGTTCGTGACTTCGCTGGCC
GCAGCCGACCTGGTGATGGGACTCCTGGTGGTGCCGCCGGCGGCCACCTTGGCGCTGACT
GGCCACTGGCCGTTGGGCGCCACTGGCTGCGAGCTGTGGACCTCGGTGGACGTGCTGTGT
GTGACCGCCAGCATCGAAACCCTGTGCGCCCTGGCCGTGGACCGCTACCTGGCTGTGACC
AACCCGCTGCGTTACGGCGCACTGGTCACCAAGCGCTGCGCCCGGACAGCTGTGGTCCTG
GTGTGGGTCGTGTCGGCCGCGGTGTCGTTTGCGCCCATCATGAGCCAGTGGTGGCGCGTA
GGGGCCGACGCCGAGGCGCAGCGCTGCCACTCCAACCCGCGCTGCTGTGCCTTCGCCTCC
AACATGCCCTACGTGCTGCTGTCCTCCTCCGTCTCCTTCTACCTTCCTCTTCTCGTGATG
CTCTTCGTCTACGCGCGGGTTTTCGTGGTGGCTACGCGCCAGCTGCGCTTGCTGCGCGGG
GAGCTGGGCCGCTTTCCGCCCGAGGAGTCTCCGCCGGCGCCGTCGCGCTCTCTGGCCCCG
GCCCCGGTGGGGACGTGCGCTCCGCCCGAAGGGGTGCCCGCCTGCGGCCGGCGGCCCGCG
CGCCTCCTGCCTCTCCGGGAACACCGGGCCCTGTGCACCTTGGGTCTCATCATGGGCACC
TTCACTCTCTGCTGGTTGCCCTTCTTTCTGGCCAACGTGCTGCGCGCCCTGGGGGGCCCC
TCTCTAGTCCCGGGCCCGGCTTTCCTTGCCCTGAACTGGCTAGGTTATGCCAATTCTGCC
TTCAACCCGCTCATCTACTGCCGCAGCCCGGACTTTCGCAGCGCCTTCCGCCGTCTTCTG
TGCCGCTGCGGCCGTCGCCTGCCTCCGGAGCCCTGCGCCGCCGCCCGCCCGGCCCTCTTC
CCCTCGGGCGTTCCTGCGGCCCGGAGCAGCCCAGCGCAGCCCAGGCTTTGCCAACGGCTC
GACGGGGCTTCTTGGGGAGTTTCTTAG
Chromosome Location
8
Locus
8p12-p11.2
External Identifiers
ResourceLink
UniProtKB IDP13945
UniProtKB Entry NameADRB3_HUMAN
GenBank Protein ID178896
GenBank Gene IDM29932
GenAtlas IDADRB3
HGNC IDHGNC:288
General References
  1. Emorine LJ, Marullo S, Briend-Sutren MM, Patey G, Tate K, Delavier-Klutchko C, Strosberg AD: Molecular characterization of the human beta 3-adrenergic receptor. Science. 1989 Sep 8;245(4922):1118-21. [PubMed:2570461]
  2. van Spronsen A, Nahmias C, Krief S, Briend-Sutren MM, Strosberg AD, Emorine LJ: The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes. Eur J Biochem. 1993 May 1;213(3):1117-24. [PubMed:8389293]
  3. Lelias JM, Kaghad M, Rodriguez M, Chalon P, Bonnin J, Dupre I, Delpech B, Bensaid M, LeFur G, Ferrara P, et al.: Molecular cloning of a human beta 3-adrenergic receptor cDNA. FEBS Lett. 1993 Jun 14;324(2):127-30. [PubMed:8389717]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334]
  5. Granneman JG, Lahners KN, Rao DD: Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block. Mol Pharmacol. 1992 Dec;42(6):964-70. [PubMed:1336117]
  6. Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen PR, Zavacki AM, Fong LG, Young SG, Lee RT: The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab. 2011 Nov 2;14(5):671-83. doi: 10.1016/j.cmet.2011.08.011. Epub 2011 Oct 6. [PubMed:21982743]
  7. Clement K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD: Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med. 1995 Aug 10;333(6):352-4. [PubMed:7609752]
  8. Fujisawa T, Ikegami H, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Oga T, Ueda H, Shintani M, Fukuda M, Ogihara T: Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. Diabetologia. 1996 Mar;39(3):349-52. [PubMed:8721782]
  9. Candelore MR, Deng L, Tota LM, Kelly LJ, Cascieri MA, Strader CD: Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant. Endocrinology. 1996 Jun;137(6):2638-41. [PubMed:8641219]
  10. Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet. 1999 Jul;22(3):239-47. [PubMed:10391210]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00368NorepinephrineapprovedyesagonistDetails
DB00571Propranololapproved, investigationalunknownantagonistDetails
DB05395AmibegroninvestigationalunknownDetails
DB06262Droxidopaapproved, investigationalyesagonistDetails
DB06190SolabegroninvestigationalunknownagonistDetails
DB01288Fenoterolapproved, investigationalunknownagonistDetails
DB01407Clenbuterolapproved, investigational, vet_approvedunknownagonistDetails
DB01102ArbutamineapprovedunknownagonistDetails
DB01064Isoprenalineapproved, investigationalyesagonistDetails
DB08807BopindololexperimentalunknownDetails
DB08808BupranololexperimentalunknownantagonistDetails
DB01363Ephedraapproved, nutraceutical, withdrawnyesagonistDetails
DB08893MirabegronapprovedyesagonistDetails
DB01001Salbutamolapproved, vet_approvedunknownDetails
DB00866Alprenololexperimental, withdrawnunknownantagonistDetails
DB00983Formoterolapproved, investigationalunknownagonistDetails
DB00938SalmeterolapprovedunknownagonistDetails
DB00871TerbutalineapprovedunknownagonistDetails
DB00960Pindololapproved, investigationalunknownagonistDetails
DB01580OxprenololapprovedunknownDetails
DB11124RacepinephrineapprovedyesagonistDetails
DB04846Celiprololapproved, investigationalunknownagonistDetails
DB00182Amphetamineapproved, illicit, investigationalunknownagonistDetails
DB00540NortriptylineapprovedunknownantagonistDetails
DB00726TrimipramineapprovedunknownbinderDetails
DB00334Olanzapineapproved, investigationalunknowninhibitorDetails
DB00217BethanidineapprovedunknownantagonistDetails
DB01365MephentermineapprovedunknownagonistDetails
DB06726Bufuralolexperimental, investigationalunknownantagonistDetails
DB13345Dihydroergocristineapproved, experimentalyesantagonistagonistDetails
DB01049Ergoloid mesylateapprovedyesantagonistagonistDetails
DB11273DihydroergocornineapprovedyesantagonistagonistDetails
DB11278DL-MethylephedrineapprovedyesagonistDetails