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Identification
NameTrimipramine
Accession NumberDB00726  (APRD00498)
TypeSmall Molecule
GroupsApproved
DescriptionTricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. [PubChem]
Structure
Thumb
Synonyms
10,11-dihydro-N,N,beta-Trimethyl-5H-dibenz[b,F]azepine-5-propanamine
5-(gamma-dimethylamino-beta-Methylpropyl)-10,11-dihydro-5H-dibenzo[b,F]azepine
5-[3-(dimethylamino)-2-Methylpropyl]-10,11-dihydro-5H-dibenz[b,F]azepine
beta-Methylimipramine
RP-7162
Sapilent
Trimeprimina
Trimeprimine
Trimeproprimine
Trimipramina
Trimipramine
Trimipraminum
External Identifiers
  • IF 6120
  • IL 6001
  • RP 7162
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Novo-tripramine Tab 100mg BPTablet100 mgOralNovopharm Limited1991-12-312015-10-26Canada
Novo-tripramine Tab 25mg BPTablet25 mgOralNovopharm Limited1991-12-312015-10-26Canada
Novo-tripramine Tab 50mg BPTablet50 mgOralNovopharm Limited1991-12-312015-10-26Canada
Nu-trimipramine Tab 100mgTablet100 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Nu-trimipramine Tab 12.5mgTablet12.5 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Nu-trimipramine Tab 25mgTablet25 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Nu-trimipramine Tab 50mgTablet50 mgOralNu Pharm Inc1993-12-312012-09-04Canada
RhotrimineTablet12.5 mgOralSanofi Aventis Canada Inc1988-12-312006-07-28Canada
RhotrimineCapsule75 mgOralSanofi Aventis Canada Inc1988-12-312007-03-29Canada
RhotrimineTablet25 mgOralSanofi Aventis Canada Inc1988-12-312006-07-28Canada
RhotrimineTablet50 mgOralSanofi Aventis Canada Inc1988-12-312006-07-28Canada
RhotrimineTablet100 mgOralSanofi Aventis Canada Inc1988-12-312007-03-29Canada
SurmontilCapsule25 mg/1OralTeva Women's Health, Inc.1990-09-30Not applicableUs
SurmontilCapsule50 mg/1OralTeva Women's Health, Inc.1990-09-30Not applicableUs
SurmontilTablet50 mgOralSanofi Aventis Canada Inc1971-12-312006-07-28Canada
SurmontilCapsule100 mg/1OralTeva Women's Health, Inc.1990-09-30Not applicableUs
SurmontilTablet25 mgOralSanofi Aventis Canada Inc1964-12-312006-07-28Canada
Surmontil 100Tablet100 mgOralAventis Pharma Inc1964-12-312005-08-01Canada
Surmontil 12.5Tablet12.5 mgOralAventis Pharma Inc1968-12-312005-08-01Canada
Surmontil 75Capsule75 mgOralAventis Pharma Inc1979-12-312005-08-01Canada
TrimipramineTablet100 mgOralAa Pharma Inc1987-12-31Not applicableCanada
TrimipramineTablet12.5 mgOralAa Pharma Inc1987-12-31Not applicableCanada
TrimipramineTablet25 mgOralAa Pharma Inc1987-12-31Not applicableCanada
TrimipramineTablet50 mgOralAa Pharma Inc1987-12-31Not applicableCanada
TrimipramineCapsule75 mgOralAa Pharma Inc1994-12-31Not applicableCanada
Trimipramine Tab 100mgTablet100 mgOralPro Doc Limitee1987-12-312010-07-13Canada
Trimipramine Tab 12.5mgTablet12.5 mgOralPro Doc Limitee1987-12-312009-07-23Canada
Trimipramine Tab 25mgTablet25 mgOralPro Doc Limitee1987-12-312010-07-13Canada
Trimipramine Tab 50mgTablet50 mgOralPro Doc Limitee1987-12-312010-07-13Canada
Trimipramine-75 - Cap 75mgCapsule75 mgOralPro Doc Limitee1995-12-312010-07-13Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-trimipramineCapsule75 mgOralApotex IncNot applicableNot applicableCanada
Apo-trimipramineTablet25 mgOralApotex IncNot applicableNot applicableCanada
Apo-trimipramineTablet50 mgOralApotex IncNot applicableNot applicableCanada
Apo-trimipramineTablet100 mgOralApotex IncNot applicableNot applicableCanada
Apo-trimipramineTablet12.5 mgOralApotex IncNot applicableNot applicableCanada
Trimipramine MaleateCapsule25 mg/1OralActavis Pharma, Inc.2011-11-21Not applicableUs
Trimipramine MaleateCapsule25 mg/1OralCross Medika s.a.2016-04-18Not applicableUs
Trimipramine MaleateCapsule50 mg/1OralActavis Pharma, Inc.2011-11-21Not applicableUs
Trimipramine MaleateCapsule50 mg/1OralCross Medika s.a.2016-04-18Not applicableUs
Trimipramine MaleateCapsule100 mg/1OralActavis Pharma, Inc.2011-10-21Not applicableUs
Trimipramine MaleateCapsule100 mg/1OralCross Medika s.a.2016-04-18Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
HerphonalTemmler
SapilentExtractumPharma
StangylSanofi-Aventis
TrimiduraMylan dura
TrimineurinHexal
TripressMylan
TydamineAspen Pharmacare
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Trimipramine maleate
ThumbNot applicableDBSALT000969
Categories
UNII6S082C9NDT
CAS number739-71-9
WeightAverage: 294.4338
Monoisotopic: 294.209598842
Chemical FormulaC20H26N2
InChI KeyZSCDBOWYZJWBIY-UHFFFAOYSA-N
InChI
InChI=1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3
IUPAC Name
(3-{2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}-2-methylpropyl)dimethylamine
SMILES
CC(CN(C)C)CN1C2=CC=CC=C2CCC2=CC=CC=C12
Pharmacology
IndicationFor the treatment of depression and depression accompanied by anxiety, agitation or sleep disturbance
Structured Indications
PharmacodynamicsTrimipramine is a tricyclic antidepressant. It was thought that tricyclic antidepressants work by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: a1 and b1 receptors are sensitized, a2 receptors are desensitised (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain. A precise mechanism for their analgesic action is unknown, but it is thought that they modulate anti-pain opioid systems in the CNS via an indirect serotonergic route. They are also effective in migraine prophylaxis, but not in abortion of acute migraine attack. The mechanism of their anti-migraine action is also thought to be serotonergic.
Mechanism of actionTrimipramine's mechanism of action differs from other tricyclic antidepressants. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).
TargetKindPharmacological actionActionsOrganismUniProt ID
Sodium-dependent serotonin transporterProteinyes
inhibitor
HumanP31645 details
Sodium-dependent noradrenaline transporterProteinyes
inhibitor
HumanP23975 details
Sodium-dependent dopamine transporterProteinunknown
inhibitor
HumanQ01959 details
5-hydroxytryptamine receptor 2AProteinunknown
agonist
HumanP28223 details
5-hydroxytryptamine receptor 1AProteinunknown
antagonist
HumanP08908 details
Alpha-1A adrenergic receptorProteinunknown
antagonist
HumanP35348 details
Alpha-1B adrenergic receptorProteinunknown
antagonist
HumanP35368 details
D(2) dopamine receptorProteinunknown
other/unknown
HumanP14416 details
Alpha-2B adrenergic receptorProteinunknown
other/unknown
HumanP18089 details
Histamine H1 receptorProteinunknown
antagonist
HumanP35367 details
5-hydroxytryptamine receptor 2CProteinunknown
antagonist
HumanP28335 details
5-hydroxytryptamine receptor 3AProteinunknown
binder
HumanP46098 details
5-hydroxytryptamine receptor 1DProteinunknown
binder
HumanP28221 details
Alpha-2A adrenergic receptorProteinunknown
desensitize the target
HumanP08913 details
D(1) dopamine receptorProtein groupunknown
binder
Humannot applicabledetails
Beta adrenergic receptorProtein groupunknown
binder
Humannot applicabledetails
Muscarinic acetylcholine receptorProtein groupunknown
binder
Humannot applicabledetails
5-hydroxytryptamine receptor 2CProteinunknown
binder
RatP08909 details
Related Articles
AbsorptionRapid absorption
Volume of distributionNot Available
Protein binding93%-96% (to plasma proteins)
Metabolism

Hepatic

Route of eliminationNot Available
Half life11-18 hrs
ClearanceNot Available
ToxicitySide effects include agitation, coma, confusion, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high fever, irregular heart rate, low body temperature, muscle rigidity, overactive reflexes, severely low blood pressure, stupor, vomiting
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Trimipramine is combined with 1,1,1,2 Tetrafluoroethane.Investigational
1,10-PhenanthrolineThe serum concentration of Trimipramine can be increased when it is combined with 1,10-Phenanthroline.Experimental
2,5-Dimethoxy-4-ethylamphetamineTrimipramine may increase the stimulatory activities of 2,5-Dimethoxy-4-ethylamphetamine.Experimental, Illicit
3,4-DichloroisocoumarinThe serum concentration of Trimipramine can be increased when it is combined with 3,4-Dichloroisocoumarin.Experimental
3,4-MethylenedioxyamphetamineTrimipramine may increase the stimulatory activities of 3,4-Methylenedioxyamphetamine.Experimental, Illicit
3,4-MethylenedioxymethamphetamineTrimipramine may increase the stimulatory activities of 3,4-Methylenedioxymethamphetamine.Experimental, Illicit
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Trimipramine can be increased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.Experimental
4-Bromo-2,5-dimethoxyamphetamineTrimipramine may increase the stimulatory activities of 4-Bromo-2,5-dimethoxyamphetamine.Experimental, Illicit
4-MethoxyamphetamineTrimipramine may decrease the antihypertensive activities of 4-Methoxyamphetamine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Trimipramine.Experimental
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the serotonergic activities of Trimipramine.Experimental
AbirateroneThe serum concentration of Trimipramine can be increased when it is combined with Abiraterone.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Trimipramine.Approved
AcenocoumarolTrimipramine may increase the anticoagulant activities of Acenocoumarol.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Trimipramine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Trimipramine.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Trimipramine.Approved
AcetophenazineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Acetophenazine.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Trimipramine.Approved, Vet Approved
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Trimipramine.Investigational
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Trimipramine.Approved
AgmatineTrimipramine may decrease the antihypertensive activities of Agmatine.Experimental, Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Trimipramine.Approved, Investigational
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Trimipramine.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Trimipramine.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Trimipramine.Approved, Illicit
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Trimipramine.Approved, Investigational
AlmotriptanThe risk or severity of adverse effects can be increased when Trimipramine is combined with Almotriptan.Approved, Investigational
AlogliptinThe serum concentration of Trimipramine can be increased when it is combined with Alogliptin.Approved
Alpha-1-proteinase inhibitorThe serum concentration of Trimipramine can be increased when it is combined with Alpha-1-proteinase inhibitor.Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Trimipramine.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Trimipramine.Approved, Illicit, Investigational
AltretamineAltretamine may increase the orthostatic hypotensive activities of Trimipramine.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Trimipramine.Approved, Investigational
AmiodaroneThe metabolism of Trimipramine can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Trimipramine.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Trimipramine.Approved
AmobarbitalThe metabolism of Trimipramine can be increased when combined with Amobarbital.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Trimipramine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Trimipramine.Experimental
AmphetamineTrimipramine may increase the stimulatory activities of Amphetamine.Approved, Illicit
AmprenavirThe serum concentration of Trimipramine can be increased when it is combined with Amprenavir.Approved
AnagrelideTrimipramine may increase the QTc-prolonging activities of Anagrelide.Approved
Antithrombin III humanThe serum concentration of Trimipramine can be increased when it is combined with Antithrombin III human.Approved
ApixabanThe serum concentration of Trimipramine can be increased when it is combined with Apixaban.Approved
ApomorphineTrimipramine may decrease the antihypertensive activities of Apomorphine.Approved, Investigational
ApraclonidineTrimipramine may decrease the antihypertensive activities of Apraclonidine.Approved
AprepitantThe serum concentration of Trimipramine can be increased when it is combined with Aprepitant.Approved, Investigational
AprotininThe serum concentration of Trimipramine can be increased when it is combined with Aprotinin.Approved, Withdrawn
ArbutamineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Arbutamine.Approved
ArformoterolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Arformoterol.Approved, Investigational
ArgatrobanThe serum concentration of Trimipramine can be increased when it is combined with Argatroban.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Trimipramine.Approved, Investigational
ArmodafinilThe metabolism of Trimipramine can be decreased when combined with Armodafinil.Approved, Investigational
Arsenic trioxideTrimipramine may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherTrimipramine may increase the QTc-prolonging activities of Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Trimipramine.Approved
AsenapineTrimipramine may increase the QTc-prolonging activities of Asenapine.Approved
AsunaprevirThe serum concentration of Trimipramine can be increased when it is combined with Asunaprevir.Approved, Investigational
AtazanavirThe metabolism of Trimipramine can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Trimipramine.Approved
AtomoxetineThe metabolism of Trimipramine can be decreased when combined with Atomoxetine.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Trimipramine.Approved, Investigational
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Trimipramine.Vet Approved
AzelastineTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Azelastine.Approved
AzithromycinTrimipramine may increase the QTc-prolonging activities of Azithromycin.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Trimipramine.Approved
BambuterolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Bambuterol.Approved
BarbexacloneThe metabolism of Trimipramine can be increased when combined with Barbexaclone.Experimental
BarbitalThe metabolism of Trimipramine can be increased when combined with Barbital.Illicit
BatimastatThe serum concentration of Trimipramine can be increased when it is combined with Batimastat.Experimental
BedaquilineTrimipramine may increase the QTc-prolonging activities of Bedaquiline.Approved
BenazeprilThe serum concentration of Trimipramine can be increased when it is combined with Benazepril.Approved, Investigational
BenmoxinBenmoxin may increase the serotonergic activities of Trimipramine.Withdrawn
BenperidolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Benperidol.Investigational
BenzamidineThe serum concentration of Trimipramine can be increased when it is combined with Benzamidine.Experimental
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Trimipramine.Approved
BenzphetamineTrimipramine may decrease the antihypertensive activities of Benzphetamine.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Trimipramine.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Trimipramine.Approved, Vet Approved
BetaxololThe metabolism of Trimipramine can be decreased when combined with Betaxolol.Approved
BethanidineTrimipramine may decrease the antihypertensive activities of Bethanidine.Approved
BexaroteneThe serum concentration of Trimipramine can be decreased when it is combined with Bexarotene.Approved, Investigational
Bi201335The serum concentration of Trimipramine can be increased when it is combined with Bi201335.Investigational
BifeprunoxThe risk or severity of adverse effects can be increased when Trimipramine is combined with Bifeprunox.Investigational
BivalirudinThe serum concentration of Trimipramine can be increased when it is combined with Bivalirudin.Approved, Investigational
BoceprevirThe metabolism of Trimipramine can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Trimipramine can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Trimipramine can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Trimipramine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Trimipramine.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Trimipramine is combined with Brexpiprazole.Approved
BrimonidineTrimipramine may decrease the antihypertensive activities of Brimonidine.Approved
BrimonidineThe therapeutic efficacy of Brimonidine can be decreased when used in combination with Trimipramine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Trimipramine.Approved, Illicit
BromocriptineTrimipramine may decrease the antihypertensive activities of Bromocriptine.Approved, Investigational
BromperidolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Trimipramine.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Trimipramine.Approved, Investigational
BuprenorphineTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Trimipramine can be decreased when combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Trimipramine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Trimipramine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Trimipramine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Trimipramine.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Trimipramine.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Trimipramine.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Trimipramine.Approved, Illicit, Vet Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Trimipramine.Approved
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Trimipramine.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Trimipramine.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Trimipramine.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Trimipramine.Approved
CandoxatrilThe serum concentration of Trimipramine can be increased when it is combined with Candoxatril.Experimental
CandoxatrilatThe serum concentration of Trimipramine can be increased when it is combined with Candoxatrilat.Experimental
CapecitabineThe metabolism of Trimipramine can be decreased when combined with Capecitabine.Approved, Investigational
CaptoprilThe serum concentration of Trimipramine can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Trimipramine can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trimipramine.Illicit, Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Trimipramine.Approved
CariprazineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Cariprazine.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Trimipramine.Approved
CaroxazoneCaroxazone may increase the serotonergic activities of Trimipramine.Withdrawn
CelecoxibThe metabolism of Trimipramine can be decreased when combined with Celecoxib.Approved, Investigational
CeliprololThe risk or severity of adverse effects can be increased when Trimipramine is combined with Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Trimipramine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Trimipramine.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Trimipramine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Trimipramine.Approved, Illicit, Vet Approved
ChloramphenicolThe metabolism of Trimipramine can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trimipramine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Trimipramine.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Trimipramine.Approved
ChloroquineTrimipramine may increase the QTc-prolonging activities of Chloroquine.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Chlorphenamine.Approved
ChlorphentermineTrimipramine may increase the stimulatory activities of Chlorphentermine.Illicit, Withdrawn
ChlorpromazineTrimipramine may increase the QTc-prolonging activities of Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Trimipramine.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Trimipramine.Approved
CholecalciferolThe metabolism of Trimipramine can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
ChymostatinThe serum concentration of Trimipramine can be increased when it is combined with Chymostatin.Experimental
CilastatinThe serum concentration of Trimipramine can be increased when it is combined with Cilastatin.Approved
CilazaprilThe serum concentration of Trimipramine can be increased when it is combined with Cilazapril.Approved
CimetidineThe metabolism of Trimipramine can be decreased when combined with Cimetidine.Approved
CinacalcetThe serum concentration of Trimipramine can be increased when it is combined with Cinacalcet.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Trimipramine.Approved, Vet Approved
CiprofloxacinTrimipramine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CirazolineTrimipramine may increase the vasopressor activities of Cirazoline.Experimental
CisaprideTrimipramine may increase the QTc-prolonging activities of Cisapride.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Trimipramine.Approved
CitalopramThe risk or severity of adverse effects can be increased when Trimipramine is combined with Citalopram.Approved
ClarithromycinThe metabolism of Trimipramine can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Trimipramine can be decreased when combined with Clemastine.Approved
ClenbuterolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Clenbuterol.Approved, Vet Approved
ClidiniumThe risk or severity of adverse effects can be increased when Trimipramine is combined with Clidinium.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Trimipramine.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Trimipramine.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Trimipramine.Approved, Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Trimipramine is combined with Clonazepam.Approved, Illicit
ClonidineTrimipramine may decrease the antihypertensive activities of Clonidine.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Trimipramine.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Trimipramine.Approved, Illicit
ClotrimazoleThe metabolism of Trimipramine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineTrimipramine may increase the QTc-prolonging activities of Clozapine.Approved
CobicistatThe serum concentration of Trimipramine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Trimipramine.Approved
CocaineThe metabolism of Trimipramine can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Trimipramine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Trimipramine.Approved
ConivaptanThe serum concentration of Trimipramine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Trimipramine.Approved
CrizotinibTrimipramine may increase the QTc-prolonging activities of Crizotinib.Approved
CyamemazineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Cyamemazine.Approved
CyclizineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Cyclobenzaprine.Approved
CyclosporineThe metabolism of Trimipramine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Trimipramine.Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Trimipramine.Approved
DabrafenibThe serum concentration of Trimipramine can be decreased when it is combined with Dabrafenib.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Trimipramine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Trimipramine is combined with Dantrolene.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Trimipramine.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Trimipramine.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Dapoxetine is combined with Trimipramine.Investigational
DarifenacinThe metabolism of Trimipramine can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Trimipramine can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Trimipramine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Trimipramine.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Trimipramine.Approved
DeferasiroxThe serum concentration of Trimipramine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Trimipramine can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Trimipramine.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Trimipramine.Approved
DesipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Desloratadine.Approved, Investigational
DesmopressinThe risk or severity of adverse effects can be increased when Trimipramine is combined with Desmopressin.Approved
DesvenlafaxineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Trimipramine.Vet Approved
DexamethasoneThe serum concentration of Trimipramine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Trimipramine.Approved
DexmedetomidineTrimipramine may decrease the antihypertensive activities of Dexmedetomidine.Approved, Vet Approved
DexmethylphenidateThe risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Trimipramine.Approved
DextroamphetamineTrimipramine may increase the stimulatory activities of Dextroamphetamine.Approved, Illicit
DextromethorphanThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Trimipramine.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Trimipramine.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Trimipramine.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Trimipramine.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Trimipramine.Approved, Illicit, Vet Approved
DicoumarolTrimipramine may increase the anticoagulant activities of Dicoumarol.Approved
DiethylpropionTrimipramine may increase the stimulatory activities of Diethylpropion.Approved, Illicit
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Trimipramine.Approved
DifenoxinThe risk or severity of adverse effects can be increased when Trimipramine is combined with Difenoxin.Approved, Illicit
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Trimipramine.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Trimipramine.Approved
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Trimipramine.Approved, Illicit
DihydroergotamineTrimipramine may decrease the antihypertensive activities of Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Trimipramine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Trimipramine.Experimental, Illicit
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Trimipramine.Illicit
DiltiazemThe metabolism of Trimipramine can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Trimipramine is combined with Dimenhydrinate.Approved
DiphenhydramineThe metabolism of Trimipramine can be decreased when combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Trimipramine.Approved, Illicit
DipivefrinTrimipramine may decrease the antihypertensive activities of Dipivefrin.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Trimipramine.Approved
DisopyramideTrimipramine may increase the QTc-prolonging activities of Disopyramide.Approved
DobutamineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Dobutamine.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Trimipramine.Approved, Investigational
DofetilideTrimipramine may increase the QTc-prolonging activities of Dofetilide.Approved
DolasetronTrimipramine may increase the QTc-prolonging activities of Dolasetron.Approved
DomperidoneTrimipramine may increase the QTc-prolonging activities of Domperidone.Approved, Investigational, Vet Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Trimipramine.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Trimipramine is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Trimipramine.Approved, Investigational
DoxycyclineThe metabolism of Trimipramine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Trimipramine.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved, Illicit
DronedaroneTrimipramine may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Trimipramine.Experimental, Illicit
DroxidopaTrimipramine may decrease the antihypertensive activities of Droxidopa.Approved, Investigational
DuloxetineDuloxetine may increase the serotonergic activities of Trimipramine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Trimipramine.Approved
EcabetThe serum concentration of Trimipramine can be increased when it is combined with Ecabet.Approved, Investigational
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Trimipramine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Trimipramine.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Trimipramine is combined with Ecopipam.Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Trimipramine.Approved
EfavirenzThe serum concentration of Trimipramine can be decreased when it is combined with Efavirenz.Approved, Investigational
ElafinThe serum concentration of Trimipramine can be increased when it is combined with Elafin.Investigational
EletriptanThe risk or severity of adverse effects can be increased when Eletriptan is combined with Trimipramine.Approved, Investigational
EliglustatTrimipramine may increase the QTc-prolonging activities of Eliglustat.Approved
EnalaprilThe serum concentration of Trimipramine can be increased when it is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe serum concentration of Trimipramine can be increased when it is combined with Enalaprilat.Approved
EnalkirenThe serum concentration of Trimipramine can be increased when it is combined with Enalkiren.Experimental
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Trimipramine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Trimipramine.Approved, Investigational
EnzalutamideThe serum concentration of Trimipramine can be decreased when it is combined with Enzalutamide.Approved
EphedraTrimipramine may decrease the antihypertensive activities of Ephedra.Approved, Nutraceutical, Withdrawn
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Trimipramine.Approved, Investigational
EpinephrineTrimipramine may decrease the antihypertensive activities of Epinephrine.Approved, Vet Approved
Ergoloid mesylateThe risk or severity of adverse effects can be increased when Trimipramine is combined with Ergoloid mesylate.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Ergonovine.Approved
ErgotamineTrimipramine may decrease the antihypertensive activities of Ergotamine.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Trimipramine.Approved, Investigational
ErythromycinTrimipramine may increase the QTc-prolonging activities of Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Trimipramine is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Trimipramine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe metabolism of Trimipramine can be decreased when combined with Esomeprazole.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Trimipramine.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Trimipramine.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Trimipramine.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Trimipramine.Approved
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Trimipramine.Approved
EthanolTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Trimipramine.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Trimipramine.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Trimipramine.Approved
EthotoinThe risk or severity of adverse effects can be increased when Trimipramine is combined with Ethotoin.Approved
Ethyl biscoumacetateTrimipramine may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Trimipramine.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Trimipramine.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Trimipramine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Trimipramine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Trimipramine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Trimipramine.Approved
EtomidateTrimipramine may decrease the antihypertensive activities of Etomidate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Trimipramine is combined with Etoperidone.Approved
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Trimipramine.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Trimipramine.Illicit, Vet Approved
EtravirineThe serum concentration of Trimipramine can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Trimipramine.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Trimipramine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Trimipramine is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Trimipramine.Approved, Illicit, Withdrawn
FenoterolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Fenoterol.Approved
FentanylThe risk or severity of adverse effects can be increased when Trimipramine is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Trimipramine.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Trimipramine.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Trimipramine.Approved
FlecainideTrimipramine may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe risk or severity of adverse effects can be increased when Trimipramine is combined with Flibanserin.Approved
FloxuridineThe metabolism of Trimipramine can be decreased when combined with Floxuridine.Approved
FluconazoleThe metabolism of Trimipramine can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Trimipramine.Approved, Illicit
FluindioneTrimipramine may increase the anticoagulant activities of Fluindione.Investigational
FlunarizineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Trimipramine.Approved, Illicit
FluorouracilThe metabolism of Trimipramine can be decreased when combined with Fluorouracil.Approved
FluoxetineThe risk or severity of adverse effects can be increased when Fluoxetine is combined with Trimipramine.Approved, Vet Approved
FlupentixolTrimipramine may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Trimipramine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Trimipramine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Trimipramine.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Trimipramine.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Trimipramine.Approved
FluvastatinThe metabolism of Trimipramine can be decreased when combined with Fluvastatin.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Trimipramine.Approved, Investigational
FormoterolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Formoterol.Approved, Investigational
FosamprenavirThe serum concentration of Trimipramine can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Trimipramine can be increased when it is combined with Fosaprepitant.Approved
FosinoprilThe serum concentration of Trimipramine can be increased when it is combined with Fosinopril.Approved
FosphenytoinThe metabolism of Trimipramine can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Trimipramine.Approved, Illicit
FrovatriptanThe risk or severity of adverse effects can be increased when Trimipramine is combined with Frovatriptan.Approved, Investigational
FurazolidoneFurazolidone may increase the serotonergic activities of Trimipramine.Approved, Vet Approved
Fusidic AcidThe serum concentration of Trimipramine can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Trimipramine.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Trimipramine is combined with gabapentin enacarbil.Approved
GabexateThe serum concentration of Trimipramine can be increased when it is combined with Gabexate.Investigational
Gadobenic acidTrimipramine may increase the QTc-prolonging activities of Gadobenic acid.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Trimipramine.Approved, Illicit
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Trimipramine.Approved, Investigational
GeldanamycinThe serum concentration of Trimipramine can be increased when it is combined with Geldanamycin.Experimental
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Trimipramine.Approved
GemfibrozilThe metabolism of Trimipramine can be decreased when combined with Gemfibrozil.Approved
GemifloxacinTrimipramine may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GepironeThe risk or severity of adverse effects can be increased when Trimipramine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Trimipramine.Approved, Illicit
GM6001The serum concentration of Trimipramine can be increased when it is combined with GM6001.Experimental
GoserelinTrimipramine may increase the QTc-prolonging activities of Goserelin.Approved
GranisetronTrimipramine may increase the QTc-prolonging activities of Granisetron.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Trimipramine.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Trimipramine.Withdrawn
GuanabenzTrimipramine may decrease the antihypertensive activities of Guanabenz.Approved
GuanfacineTrimipramine may decrease the antihypertensive activities of Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Trimipramine.Approved, Illicit, Withdrawn
HaloperidolTrimipramine may increase the QTc-prolonging activities of Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Trimipramine.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Trimipramine.Approved, Illicit
HexobarbitalThe metabolism of Trimipramine can be increased when combined with Hexobarbital.Approved
HirulogThe serum concentration of Trimipramine can be increased when it is combined with Hirulog.Experimental
HydracarbazineHydracarbazine may increase the serotonergic activities of Trimipramine.Approved
HydrocodoneTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Trimipramine.Approved, Vet Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Trimipramine.Approved, Illicit
Hydroxyamphetamine hydrobromideTrimipramine may increase the stimulatory activities of Hydroxyamphetamine hydrobromide.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Trimipramine.Approved
IbutilideTrimipramine may increase the QTc-prolonging activities of Ibutilide.Approved
IdelalisibThe serum concentration of Trimipramine can be increased when it is combined with Idelalisib.Approved
idraparinuxThe serum concentration of Trimipramine can be increased when it is combined with idraparinux.Investigational
IloperidoneTrimipramine may increase the QTc-prolonging activities of Iloperidone.Approved
ImatinibThe metabolism of Trimipramine can be decreased when combined with Imatinib.Approved
ImidaprilThe serum concentration of Trimipramine can be increased when it is combined with Imidapril.Investigational
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Trimipramine.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Trimipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Trimipramine can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Trimipramine.Approved, Investigational
IobenguaneThe therapeutic efficacy of Iobenguane can be decreased when used in combination with Trimipramine.Approved
IproclozideIproclozide may increase the serotonergic activities of Trimipramine.Withdrawn
IproniazidIproniazid may increase the serotonergic activities of Trimipramine.Withdrawn
IrbesartanThe metabolism of Trimipramine can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Trimipramine.Approved, Investigational
IsavuconazoniumThe metabolism of Trimipramine can be decreased when combined with Isavuconazonium.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the serotonergic activities of Trimipramine.Approved
IsoetarineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Isoetarine.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Trimipramine.Approved, Vet Approved
IsoflurophateThe serum concentration of Trimipramine can be increased when it is combined with Isoflurophate.Approved, Withdrawn
IsoniazidThe metabolism of Trimipramine can be decreased when combined with Isoniazid.Approved
IsoprenalineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Isoprenaline.Approved
IsradipineThe metabolism of Trimipramine can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Trimipramine can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Trimipramine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Trimipramine.Approved, Vet Approved
IxazomibThe serum concentration of Trimipramine can be increased when it is combined with Ixazomib.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Trimipramine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Trimipramine.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Trimipramine.Approved
KetoconazoleThe metabolism of Trimipramine can be decreased when combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Trimipramine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Trimipramine.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Trimipramine.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Trimipramine.Approved
LeflunomideThe metabolism of Trimipramine can be decreased when combined with Leflunomide.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Trimipramine.Approved
LenvatinibTrimipramine may increase the QTc-prolonging activities of Lenvatinib.Approved
LepirudinThe serum concentration of Trimipramine can be increased when it is combined with Lepirudin.Approved
LeuprolideTrimipramine may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Trimipramine.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Trimipramine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Trimipramine is combined with Levodopa.Approved
LevofloxacinTrimipramine may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Trimipramine.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Trimipramine is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Trimipramine.Approved
LevothyroxineLevothyroxine may increase the arrhythmogenic activities of Trimipramine.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Trimipramine.Approved, Vet Approved
LinagliptinThe serum concentration of Trimipramine can be increased when it is combined with Linagliptin.Approved
LinezolidLinezolid may increase the serotonergic activities of Trimipramine.Approved, Investigational
LiothyronineLiothyronine may increase the arrhythmogenic activities of Trimipramine.Approved, Vet Approved
LiotrixLiotrix may increase the arrhythmogenic activities of Trimipramine.Approved
LisdexamfetamineTrimipramine may increase the stimulatory activities of Lisdexamfetamine.Approved, Investigational
LisinoprilThe serum concentration of Trimipramine can be increased when it is combined with Lisinopril.Approved, Investigational
LithiumLithium may increase the neurotoxic activities of Trimipramine.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Trimipramine.Illicit
LofexidineTrimipramine may decrease the antihypertensive activities of Lofexidine.Approved, Investigational
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Trimipramine.Approved
LopinavirThe metabolism of Trimipramine can be decreased when combined with Lopinavir.Approved
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Trimipramine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Trimipramine.Approved
LorcaserinThe risk or severity of adverse effects can be increased when Trimipramine is combined with Lorcaserin.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Trimipramine.Approved
LovastatinThe metabolism of Trimipramine can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Trimipramine.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Trimipramine.Investigational
LuliconazoleThe serum concentration of Trimipramine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Trimipramine can be decreased when it is combined with Lumacaftor.Approved
LumefantrineTrimipramine may increase the QTc-prolonging activities of Lumefantrine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Trimipramine.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved, Vet Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Trimipramine.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Maprotiline.Approved
MebanazineMebanazine may increase the serotonergic activities of Trimipramine.Withdrawn
MeclizineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Trimipramine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Trimipramine.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Trimipramine.Approved
MephedroneTrimipramine may increase the stimulatory activities of Mephedrone.Investigational
MephentermineTrimipramine may increase the vasopressor activities of Mephentermine.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Trimipramine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Trimipramine.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Trimipramine.Approved
MetaraminolTrimipramine may increase the vasopressor activities of Metaraminol.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Trimipramine.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Trimipramine.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Trimipramine.Approved, Illicit
MethamphetamineTrimipramine may decrease the antihypertensive activities of Methamphetamine.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Trimipramine.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Trimipramine.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Trimipramine.Approved, Vet Approved
MethohexitalThe metabolism of Trimipramine can be increased when combined with Methohexital.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Trimipramine.Approved
MethotrimeprazineTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxamineTrimipramine may increase the vasopressor activities of Methoxamine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Trimipramine.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Trimipramine is combined with Methsuximide.Approved
Methylene blueTrimipramine may increase the serotonergic activities of Methylene blue.Investigational
MethylphenidateThe risk or severity of adverse effects can be increased when Methylphenidate is combined with Trimipramine.Approved, Investigational
MethylphenobarbitalThe metabolism of Trimipramine can be increased when combined with Methylphenobarbital.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Trimipramine.Approved, Vet Approved
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Trimipramine.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Trimipramine.Approved, Investigational
MetyrosineTrimipramine may increase the sedative activities of Metyrosine.Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Trimipramine.Approved, Illicit
MidodrineTrimipramine may increase the vasopressor activities of Midodrine.Approved
MifepristoneThe serum concentration of Trimipramine can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Trimipramine is combined with Milnacipran.Approved
MinaprineMinaprine may increase the serotonergic activities of Trimipramine.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Trimipramine.Approved
MirtazapineTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Trimipramine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Trimipramine.Approved, Investigational
MMDATrimipramine may increase the stimulatory activities of MMDA.Experimental, Illicit
MoclobemideMoclobemide may increase the serotonergic activities of Trimipramine.Approved
ModafinilThe serum concentration of Trimipramine can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilThe serum concentration of Trimipramine can be increased when it is combined with Moexipril.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Trimipramine.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Trimipramine.Approved, Investigational
MoxifloxacinTrimipramine may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
MoxonidineThe therapeutic efficacy of Moxonidine can be decreased when used in combination with Trimipramine.Approved
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Trimipramine.Approved, Investigational
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Trimipramine can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Trimipramine.Approved
NafamostatThe serum concentration of Trimipramine can be increased when it is combined with Nafamostat.Investigational
NafcillinThe serum concentration of Trimipramine can be decreased when it is combined with Nafcillin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Trimipramine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Trimipramine.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Trimipramine.Approved, Vet Approved
NaphazolineTrimipramine may decrease the antihypertensive activities of Naphazoline.Approved
NaratriptanThe risk or severity of adverse effects can be increased when Trimipramine is combined with Naratriptan.Approved, Investigational
NCX 4016The serum concentration of Trimipramine can be increased when it is combined with NCX 4016.Investigational
NefazodoneThe metabolism of Trimipramine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Trimipramine can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Trimipramine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Trimipramine can be increased when combined with Nevirapine.Approved
NialamideNialamide may increase the serotonergic activities of Trimipramine.Withdrawn
NicardipineThe metabolism of Trimipramine can be decreased when combined with Nicardipine.Approved
NicorandilTrimipramine may increase the hypotensive activities of Nicorandil.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Trimipramine.Approved
NilotinibTrimipramine may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Trimipramine.Approved
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Trimipramine.Approved
NitroaspirinThe serum concentration of Trimipramine can be increased when it is combined with Nitroaspirin.Investigational
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Trimipramine.Approved, Vet Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Trimipramine.Approved
NorepinephrineTrimipramine may decrease the antihypertensive activities of Norepinephrine.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Trimipramine.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Trimipramine.Approved
OctamoxinOctamoxin may increase the serotonergic activities of Trimipramine.Withdrawn
OfloxacinTrimipramine may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Trimipramine.Approved, Investigational
OlaparibThe metabolism of Trimipramine can be decreased when combined with Olaparib.Approved
OlodaterolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Olodaterol.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Olopatadine.Approved
OmapatrilatThe serum concentration of Trimipramine can be increased when it is combined with Omapatrilat.Investigational
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Trimipramine.Approved
OmeprazoleThe metabolism of Trimipramine can be decreased when combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronTrimipramine may increase the QTc-prolonging activities of Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Trimipramine.Approved, Illicit
OrciprenalineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Orciprenaline.Approved
OrphenadrineTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Trimipramine.Investigational
OsimertinibThe serum concentration of Trimipramine can be increased when it is combined with Osimertinib.Approved
OtamixabanThe serum concentration of Trimipramine can be increased when it is combined with Otamixaban.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Trimipramine.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Trimipramine.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Trimipramine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Trimipramine.Approved, Illicit, Investigational
OxymetazolineTrimipramine may decrease the antihypertensive activities of Oxymetazoline.Approved
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Trimipramine.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Trimipramine.Approved, Vet Approved
PalbociclibThe serum concentration of Trimipramine can be increased when it is combined with Palbociclib.Approved
PaliperidoneTrimipramine may decrease the antihypertensive activities of Paliperidone.Approved
PalonosetronPalonosetron may increase the serotonergic activities of Trimipramine.Approved, Investigational
PanobinostatThe serum concentration of Trimipramine can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe metabolism of Trimipramine can be decreased when combined with Pantoprazole.Approved
ParaldehydeTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PargylinePargyline may increase the serotonergic activities of Trimipramine.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Paroxetine is combined with Trimipramine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Trimipramine.Approved
Peginterferon alfa-2bThe serum concentration of Trimipramine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentamidineTrimipramine may increase the QTc-prolonging activities of Pentamidine.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Trimipramine.Approved, Vet Approved
PentobarbitalThe metabolism of Trimipramine can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved
PerazineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Perazine.Investigational
PerflutrenTrimipramine may increase the QTc-prolonging activities of Perflutren.Approved
PergolideTrimipramine may decrease the antihypertensive activities of Pergolide.Approved, Vet Approved, Withdrawn
PerindoprilThe serum concentration of Trimipramine can be increased when it is combined with Perindopril.Approved
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Trimipramine.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Trimipramine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Trimipramine.Approved
PhenelzinePhenelzine may increase the serotonergic activities of Trimipramine.Approved
PhenindioneTrimipramine may increase the anticoagulant activities of Phenindione.Approved
PheniprazinePheniprazine may increase the serotonergic activities of Trimipramine.Withdrawn
PhenobarbitalThe metabolism of Trimipramine can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Trimipramine.Approved
PhenoxypropazinePhenoxypropazine may increase the serotonergic activities of Trimipramine.Withdrawn
PhenprocoumonTrimipramine may increase the anticoagulant activities of Phenprocoumon.Approved
PhentermineTrimipramine may increase the stimulatory activities of Phentermine.Approved, Illicit
PhenylephrineTrimipramine may increase the vasopressor activities of Phenylephrine.Approved
PhenylpropanolamineTrimipramine may decrease the antihypertensive activities of Phenylpropanolamine.Approved, Vet Approved, Withdrawn
PhenytoinThe metabolism of Trimipramine can be increased when combined with Phenytoin.Approved, Vet Approved
PhosphoramidonThe serum concentration of Trimipramine can be increased when it is combined with Phosphoramidon.Experimental
PimozideTrimipramine may increase the QTc-prolonging activities of Pimozide.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Trimipramine.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Pipotiazine.Approved
PirbuterolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Pirbuterol.Approved
PiritramideThe risk or severity of adverse effects can be increased when Trimipramine is combined with Piritramide.Investigational
PirlindolePirlindole may increase the serotonergic activities of Trimipramine.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Trimipramine.Approved
PivhydrazinePivhydrazine may increase the serotonergic activities of Trimipramine.Withdrawn
PizotifenThe risk or severity of adverse effects can be increased when Trimipramine is combined with Pizotifen.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Trimipramine.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Trimipramine.Approved
PosaconazoleThe metabolism of Trimipramine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleTrimipramine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Trimipramine.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Trimipramine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Trimipramine.Approved, Illicit
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Trimipramine.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Trimipramine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Trimipramine.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trimipramine.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Trimipramine is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Trimipramine.Approved
PrimaquineTrimipramine may increase the QTc-prolonging activities of Primaquine.Approved
PrimidoneThe metabolism of Trimipramine can be increased when combined with Primidone.Approved, Vet Approved
PrinomastatThe serum concentration of Trimipramine can be increased when it is combined with Prinomastat.Investigational
ProcainamideTrimipramine may increase the QTc-prolonging activities of Procainamide.Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Trimipramine.Approved, Investigational, Vet Approved
ProcarbazineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Procarbazine.Approved
ProcaterolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Procaterol.Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Trimipramine.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Trimipramine.Approved, Vet Approved
PromazineTrimipramine may increase the QTc-prolonging activities of Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Promethazine.Approved
PropafenoneTrimipramine may increase the QTc-prolonging activities of Propafenone.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Trimipramine.Approved, Vet Approved
PropericiazineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Propericiazine.Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Trimipramine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Trimipramine.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Trimipramine.Approved, Investigational
ProthipendylThe risk or severity of adverse effects can be increased when Trimipramine is combined with Prothipendyl.Investigational
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Trimipramine.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Trimipramine.Approved
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Trimipramine.Investigational
PseudoephedrineTrimipramine may decrease the antihypertensive activities of Pseudoephedrine.Approved
PyrimethamineThe metabolism of Trimipramine can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Trimipramine.Approved, Illicit
QuetiapineTrimipramine may increase the QTc-prolonging activities of Quetiapine.Approved
QuinaprilThe serum concentration of Trimipramine can be increased when it is combined with Quinapril.Approved, Investigational
QuinidineTrimipramine may increase the QTc-prolonging activities of Quinidine.Approved
QuinineTrimipramine may increase the QTc-prolonging activities of Quinine.Approved
RacecadotrilThe serum concentration of Trimipramine can be increased when it is combined with Racecadotril.Investigational
RacloprideThe risk or severity of adverse effects can be increased when Trimipramine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Trimipramine is combined with Ramelteon.Approved, Investigational
RamiprilThe serum concentration of Trimipramine can be increased when it is combined with Ramipril.Approved
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Trimipramine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Trimipramine.Approved, Investigational
RasagilineRasagiline may increase the serotonergic activities of Trimipramine.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Trimipramine.Approved
RemikirenThe serum concentration of Trimipramine can be increased when it is combined with Remikiren.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Trimipramine.Approved, Withdrawn
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Trimipramine.Approved
RifabutinThe metabolism of Trimipramine can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Trimipramine can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Trimipramine can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Trimipramine.Approved, Investigational
RisperidoneTrimipramine may decrease the antihypertensive activities of Risperidone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Trimipramine is combined with Ritanserin.Investigational
RitobegronTrimipramine may increase the stimulatory activities of Ritobegron.Investigational
RitodrineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Ritodrine.Approved
RitonavirThe metabolism of Trimipramine can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Trimipramine can be increased when it is combined with Rivaroxaban.Approved
RizatriptanThe risk or severity of adverse effects can be increased when Trimipramine is combined with Rizatriptan.Approved
RolapitantThe metabolism of Trimipramine can be decreased when combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Trimipramine.Approved, Investigational
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Trimipramine.Vet Approved
RopiniroleTrimipramine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Trimipramine.Approved
RotigotineTrimipramine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Trimipramine.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Trimipramine.Experimental
SafrazineSafrazine may increase the serotonergic activities of Trimipramine.Withdrawn
Sage 547The risk or severity of adverse effects can be increased when Trimipramine is combined with Sage 547.Investigational
SalbutamolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Salbutamol.Approved, Vet Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Trimipramine.Approved, Vet Approved
SalmeterolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Salmeterol.Approved
SaquinavirThe metabolism of Trimipramine can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Trimipramine can be increased when it is combined with Saxagliptin.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Trimipramine can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineSelegiline may increase the serotonergic activities of Trimipramine.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Trimipramine.Approved
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Trimipramine.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Sertraline is combined with Trimipramine.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Trimipramine.Approved, Vet Approved
SildenafilThe metabolism of Trimipramine can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Trimipramine.Approved
SiltuximabThe serum concentration of Trimipramine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Trimipramine can be increased when it is combined with Simeprevir.Approved
SitagliptinThe serum concentration of Trimipramine can be increased when it is combined with Sitagliptin.Approved, Investigational
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Trimipramine.Approved
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Trimipramine.Approved, Investigational
SotalolTrimipramine may increase the QTc-prolonging activities of Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Trimipramine.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Trimipramine.Experimental
SpiraprilThe serum concentration of Trimipramine can be increased when it is combined with Spirapril.Approved
St. John's WortThe metabolism of Trimipramine can be increased when combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Trimipramine can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Trimipramine.Approved, Investigational
SulfadiazineThe metabolism of Trimipramine can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Trimipramine can be decreased when combined with Sulfamethoxazole.Approved
SulfisoxazoleThe metabolism of Trimipramine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Trimipramine.Approved
SumatriptanThe risk or severity of adverse effects can be increased when Sumatriptan is combined with Trimipramine.Approved, Investigational
SuvorexantTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Trimipramine.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Trimipramine.Approved
TandospironeThe risk or severity of adverse effects can be increased when Trimipramine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Trimipramine is combined with Tasimelteon.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Trimipramine.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Trimipramine.Approved
Tedizolid PhosphateTedizolid Phosphate may increase the serotonergic activities of Trimipramine.Approved
TelaprevirThe metabolism of Trimipramine can be decreased when combined with Telaprevir.Approved
TelavancinTrimipramine may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinThe metabolism of Trimipramine can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Trimipramine.Approved
TemocaprilThe serum concentration of Trimipramine can be increased when it is combined with Temocapril.Experimental, Investigational
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Trimipramine.Approved
TerbinafineThe metabolism of Trimipramine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerbutalineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Terbutaline.Approved
TetrabenazineTrimipramine may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Trimipramine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Trimipramine.Investigational
ThalidomideTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe metabolism of Trimipramine can be increased when combined with Thiamylal.Approved, Vet Approved
ThiopentalThe metabolism of Trimipramine can be increased when combined with Thiopental.Approved, Vet Approved
ThioproperazineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Thioproperazine.Approved
ThioridazineTrimipramine may increase the QTc-prolonging activities of Thioridazine.Approved
ThiorphanThe serum concentration of Trimipramine can be increased when it is combined with Thiorphan.Experimental
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Trimipramine.Approved
Thyroid, porcineThyroid, porcine may increase the arrhythmogenic activities of Trimipramine.Approved
TiagabineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Trimipramine is combined with Tiapride.Investigational
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Trimipramine.Approved
TiclopidineThe metabolism of Trimipramine can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Trimipramine.Vet Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Trimipramine.Approved
TipranavirThe metabolism of Trimipramine can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineTrimipramine may decrease the antihypertensive activities of Tizanidine.Approved
TocilizumabThe serum concentration of Trimipramine can be decreased when it is combined with Tocilizumab.Approved
TolbutamideThe metabolism of Trimipramine can be decreased when combined with Tolbutamide.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Trimipramine.Approved, Withdrawn
ToloxatoneToloxatone may increase the serotonergic activities of Trimipramine.Approved
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Trimipramine.Approved
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Trimipramine.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Trimipramine.Approved, Investigational
ToremifeneTrimipramine may increase the QTc-prolonging activities of Toremifene.Approved, Investigational
TramadolTrimipramine may increase the neuroexcitatory activities of Tramadol.Approved, Investigational
TrandolaprilThe serum concentration of Trimipramine can be increased when it is combined with Trandolapril.Approved
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the serotonergic activities of Trimipramine.Experimental
TranylcypromineTranylcypromine may increase the serotonergic activities of Trimipramine.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Trimipramine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Trimipramine.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Trimipramine.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Trimipramine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Trimipramine.Approved, Vet Approved
TrimethoprimThe metabolism of Trimipramine can be decreased when combined with Trimethoprim.Approved, Vet Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Trimipramine.Approved
TropisetronTropisetron may increase the serotonergic activities of Trimipramine.Investigational
UbenimexThe serum concentration of Trimipramine can be increased when it is combined with Ubenimex.Experimental
Uc1010The risk or severity of adverse effects can be increased when Trimipramine is combined with Uc1010.Investigational
UlinastatinThe serum concentration of Trimipramine can be increased when it is combined with Ulinastatin.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Trimipramine.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Trimipramine.Approved
Valproic AcidThe serum concentration of Trimipramine can be increased when it is combined with Valproic Acid.Approved, Investigational
ValsartanThe metabolism of Trimipramine can be decreased when combined with Valsartan.Approved, Investigational
VandetanibTrimipramine may increase the QTc-prolonging activities of Vandetanib.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Trimipramine.Approved
VemurafenibTrimipramine may increase the QTc-prolonging activities of Vemurafenib.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Trimipramine.Approved
VenlafaxineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Trimipramine.Approved
VerapamilThe metabolism of Trimipramine can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Trimipramine is combined with Vigabatrin.Approved
VilanterolThe risk or severity of adverse effects can be increased when Trimipramine is combined with Vilanterol.Approved
VilazodoneThe risk or severity of adverse effects can be increased when Trimipramine is combined with Vilazodone.Approved
VildagliptinThe serum concentration of Trimipramine can be increased when it is combined with Vildagliptin.Approved, Investigational
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Trimipramine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Trimipramine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Trimipramine.Approved
VoriconazoleThe metabolism of Trimipramine can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Vortioxetine.Approved
WarfarinTrimipramine may increase the anticoagulant activities of Warfarin.Approved
XimelagatranThe serum concentration of Trimipramine can be increased when it is combined with Ximelagatran.Approved, Investigational, Withdrawn
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Trimipramine.Vet Approved
XylometazolineTrimipramine may decrease the antihypertensive activities of Xylometazoline.Approved
Ym150The serum concentration of Trimipramine can be increased when it is combined with Ym150.Investigational
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Trimipramine.Approved, Vet Approved
ZafirlukastThe metabolism of Trimipramine can be decreased when combined with Zafirlukast.Approved, Investigational
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Trimipramine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Trimipramine is combined with Ziconotide.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Trimipramine.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Zimelidine.Withdrawn
ZiprasidoneTrimipramine may increase the QTc-prolonging activities of Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Trimipramine.Vet Approved
ZolmitriptanThe risk or severity of adverse effects can be increased when Zolmitriptan is combined with Trimipramine.Approved, Investigational
ZolpidemTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Trimipramine is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Trimipramine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Trimipramine.Approved
ZuclopenthixolTrimipramine may increase the QTc-prolonging activities of Zuclopenthixol.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesN06AA06
AHFS Codes
  • 28:16.04.28
PDB EntriesNot Available
FDA labelDownload (152 KB)
MSDSDownload (75 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9739
Blood Brain Barrier+0.9861
Caco-2 permeable+0.8059
P-glycoprotein substrateSubstrate0.6559
P-glycoprotein inhibitor IInhibitor0.8838
P-glycoprotein inhibitor IIInhibitor0.8826
Renal organic cation transporterInhibitor0.7098
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.6698
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9094
CYP450 3A4 inhibitorNon-inhibitor0.6132
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6083
Ames testNon AMES toxic0.8109
CarcinogenicityNon-carcinogens0.9021
BiodegradationNot ready biodegradable0.9886
Rat acute toxicity2.8709 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9065
hERG inhibition (predictor II)Inhibitor0.8271
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
CapsuleOral75 mg
TabletOral100 mg
TabletOral12.5 mg
TabletOral25 mg
TabletOral50 mg
CapsuleOral100 mg/1
CapsuleOral25 mg/1
CapsuleOral50 mg/1
Prices
Unit descriptionCostUnit
Trimipramine maleate powder51.0USD g
Surmontil 100 mg capsule5.92USD capsule
Surmontil 50 mg capsule4.15USD capsule
Trimipramine Maleate 50 mg capsule3.27USD capsule
Trimipramine 50 mg capsule3.14USD capsule
Surmontil 25 mg capsule2.49USD capsule
Trimipramine 25 mg capsule1.92USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point45 °CPhysProp
water solubilitySlightly solubleNot Available
logP4.2Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.026 mg/mLALOGPS
logP4.67ALOGPS
logP4.76ChemAxon
logS-4ALOGPS
pKa (Strongest Basic)9.42ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area6.48 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity95.02 m3·mol-1ChemAxon
Polarizability35.67 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0a4m-5790000000-53c724efbeeb45818f39View in MoNA
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dibenzazepines. These are compounds with two benzene rings connected by an azepine ring. Azepine is an unsaturated seven-member heterocycle with one nitrogen atom replacing a carbon atom.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzazepines
Sub ClassDibenzazepines
Direct ParentDibenzazepines
Alternative Parents
Substituents
  • Dibenzazepine
  • Alkyldiarylamine
  • Azepine
  • Benzenoid
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Serotonin:sodium symporter activity
Specific Function:
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin an...
Gene Name:
SLC6A4
Uniprot ID:
P31645
Molecular Weight:
70324.165 Da
References
  1. Diamond M, Kelly JP, Connor TJ: Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade. Eur Neuropsychopharmacol. 2006 Oct;16(7):481-90. Epub 2006 Jan 4. [PubMed:16388933 ]
  2. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Norepinephrine:sodium symporter activity
Specific Function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A2
Uniprot ID:
P23975
Molecular Weight:
69331.42 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Monoamine transmembrane transporter activity
Specific Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular Weight:
68494.255 Da
References
  1. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Virus receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates...
Gene Name:
HTR2A
Uniprot ID:
P28223
Molecular Weight:
52602.58 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G pro...
Gene Name:
HTR1A
Uniprot ID:
P08908
Molecular Weight:
46106.335 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1A
Uniprot ID:
P35348
Molecular Weight:
51486.005 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1B
Uniprot ID:
P35368
Molecular Weight:
56835.375 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Potassium channel regulator activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Gene Name:
DRD2
Uniprot ID:
P14416
Molecular Weight:
50618.91 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Epinephrine binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phent...
Gene Name:
ADRA2B
Uniprot ID:
P18089
Molecular Weight:
49565.8 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modul...
Gene Name:
HTR2C
Uniprot ID:
P28335
Molecular Weight:
51820.705 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. PDSP Ki Database [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Voltage-gated potassium channel activity
Specific Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Gene Name:
HTR3A
Uniprot ID:
P46098
Molecular Weight:
55279.835 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate c...
Gene Name:
HTR1D
Uniprot ID:
P28221
Molecular Weight:
41906.38 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
desensitize the target
General Function:
Thioesterase binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianser...
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular Weight:
48956.275 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein group
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
G-protein coupled amine receptor activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Components:
NameUniProt IDDetails
D(1A) dopamine receptorP21728 Details
D(1B) dopamine receptorP21918 Details
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein group
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Receptor signaling protein activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Components:
NameUniProt IDDetails
Beta-1 adrenergic receptorP08588 Details
Beta-2 adrenergic receptorP07550 Details
Beta-3 adrenergic receptorP13945 Details
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]
Kind
Protein group
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Phosphatidylinositol phospholipase c activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Components:
NameUniProt IDDetails
Muscarinic acetylcholine receptor M1P11229 Details
Muscarinic acetylcholine receptor M2P08172 Details
Muscarinic acetylcholine receptor M3P20309 Details
Muscarinic acetylcholine receptor M4P08173 Details
Muscarinic acetylcholine receptor M5P08912 Details
References
  1. Eikmeier G, Muszynski K, Berger M, Gastpar M: High-dose trimipramine in acute schizophrenia. Preliminary results of an open trial. Pharmacopsychiatry. 1990 Sep;23(5):212-4. [PubMed:1979173 ]
Kind
Protein
Organism
Rat
Pharmacological action
unknown
Actions
binder
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modul...
Gene Name:
Htr2c
Uniprot ID:
P08909
Molecular Weight:
51916.005 Da
References
  1. Berger M, Gastpar M: Trimipramine: a challenge to current concepts on antidepressives. Eur Arch Psychiatry Clin Neurosci. 1996;246(5):235-9. [PubMed:8863001 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Baumann P: Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. [PubMed:8968657 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23