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Displaying drugs 301 - 325 of 13635 in total

Estetrol

Naturally or synthetically produced steroid estrogens have a wide range of pharmaceutical uses ranging from hormonal contraception to the treatment of menopausal symptoms. Estetrol (E4) is a native estrogen occurring naturally during pregnancy, but can be synthesized from a plant source and used for contraception. It is more potent and...
Approved
Investigational
Matched Iupac: … (1R,2R,3R,3aS,3bR,9bS,11aS)-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene …
Matched Description: … from a plant source and used for contraception. ... [L33179] In Canada, Nextstellis was approved for use in March 2021; it was developed by Mithra and is ... The combination of drospirenone and estetrol offers a new choice with a favourable safety profile for …
Matched Categories: … Hormonal Contraceptives for Systemic Use …

Cefoxitin

Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.
Approved
Matched Description: … Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … Cefoxitin for Injection ... Cefoxitin for Injection USP …

Glucagon

Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and the release of glucose.[L7640,L7643] Glucagon was granted FDA...
Approved
Matched Description: … Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit …
Matched Products: … GLUCAGEN FOR INJECTION 1 mg/ml …

Ketoconazole

Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation...
Approved
Investigational
Matched Description: … [A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in ... Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal ... [A188054] At this time it was considered a significant improvement over previous antifungals, [miconazole …
Matched Categories: … Antifungals for Topical Use ... Antimycotics for Systemic Use ... Antiinfectives for Systemic Use ... Antifungals for Dermatological Use …
Matched Products: … Nizoral A-D ... A-BE LOTION …

Lesinurad

Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with...
Approved
Investigational
Matched Description: … uric acid levels with a xanthine oxidase inhibitor alone. ... Marketed as the product Zurampic, it is indicated for use in combination with a xanthine oxidase inhibitor ... In August 2017, a combination oral therapy consisting of lesinurad and [DB00437] was FDA-approved under …

Acetylcarnitine

Acetylcarnitine is an investigational drug in the United states, Italy, United Kingdom, China, Israel, and Norway, and it is approved in Italy, Portugal, Argentina, Chile, Philippines, Australia, and India. Acetylcarnitine can be synthesized, but it is also naturally found in adequate amounts in healthy humans. In human plasma and tissues,...
Approved
Investigational
Matched Description: … Acetylcarnitine can be synthesized, but it is also naturally found in adequate amounts in healthy humans ... Acetylcarnitine is an investigational drug in the United states, Italy, United Kingdom, China, Israel ... , and Norway, and it is approved in Italy, Portugal, Argentina, Chile, Philippines, Australia, and India …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …

Clobazam

Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others. . Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike older 1,4-benzodiazepines, clobazam has...
Approved
Illicit
Matched Description: … [A256958] In 2005, clobazam also received approval from Health Canada as an add-on therapy for generalized ... [A521,A522] In October 21, 2011, the FDA approved clobazam as an adjunctive treatment for seizures associated ... [A256868] Additionally, clobazam is believed to be a partial agonist to the GABAA receptor …
Matched Categories: … GABA-A Receptor Agonists …

Cholestyramine

Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
Approved
Investigational
Matched Description: … Cholestyramine or colestyramine is a bile acid sequestrant. ... Cholestyramine resin is quite hydrophilic, but insoluble in water. …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Medications that reduce magnesium levels ... Hypolipidemic Agents Indicated for Hyperlipidemia ... Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia …
Matched Products: … Cholestyramine Powder for Suspension ... Cholestyramine for Oral Suspension ... PHL-cholestyramine Powder for Suspension 400gm/can …

Perindopril

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to...
Approved
Matched Description: … Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of ... It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration ... Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor …
Matched Mixtures name: … PERINDO/IN RAT T 5/1.25 ... PERINDO/IN RAT T 5/1.25 ... PERINDO IN 1A PHA4/1.25MG …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Atezolizumab

Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted...
Approved
Investigational
Matched Description: … [L7489] In November 2022, the manufacturer (Genentech) voluntarily withdrew the use of atezolizumab for ... Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing ... inhibition of immune responses seen in some cancers. …
Matched Products: … Tecentriq 60mg/ml Concentrate for Solution for Infusion ... TECENTRIQ CONCENTRATE FOR SOLUTION FOR INFUSION 840MG/14ML ... TECENTRIQ CONCENTRATE FOR SOLUTION FOR INFUSION 1200 MG/ 20 ML …

Diamorphine

Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is controlled under...
Approved
Illicit
Investigational
Matched Description: … It is a controlled substance (opium derivative) listed in the U.S. ... However, under the name diamorphine, heroin is a legal prescription drug in the United Kingdom. ... Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. …
Matched Categories: … Drugs Used in Opioid Dependence ... Drugs Used in Addictive Disorders …

Citalopram

Citalopram is an antidepressant belonging to the class of selective serotonin-reuptake inhibitors (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] Citalopram enhances serotonergic transmission through the...
Approved
Matched Description: … [A261316] Citalopram was approved by the FDA in 1998 for the treatment of depression in adults 18 ... metabolites among all SSRIs. ... It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing …
Matched Categories: … Monoamine Oxidase A Substrates ... Antidepressive Agents Indicated for Depression …

Idarucizumab

Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and inactivates the oral anticoagulant dabigatran, thereby reversing its anticoagulant effect. As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran includes bleeding, espeically when...
Approved
Matched Description: … dabigatran-associated bleeding in life-threatening or surgically induced situations. ... Approved under the tradename Praxbind (FDA), idarucizumab is indicated for the emergency treatment of ... Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype …
Matched Products: … PRAXBIND Solution for Injection/Infusion 50 mg/ml ... PRAXBIND SOLUTION FOR INJECTION/INFUSION 50 MG/ML …

Avelumab

Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. Avelumab was first approved by the FDA on March 23, 2017. On September 18 and December 18 of the same year,...
Approved
Investigational
Matched Description: … Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) ... It is used in the treatment of Merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell …
Matched Products: … BAVENCIO CONCENTRATE FOR SOLUTION FOR INFUSION 200MG/10ML …

Resmetirom

Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD). Thyroid hormones directly regulate lipid metabolism in the liver;...
Approved
Investigational
Matched Description: … function, such as low serum thyroid hormone levels, is often observed in NAFLD. ... Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. ... first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a …

Bulevirtide

Hepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development of cirrhosis, severe decompensation of liver function, and an increased risk of mortality.[A226340,L30235] Until recently, there have been extremely limited treatments available for Hepatitis D infection. Bulevirtide, also known as Hepcludex, is a...
Approved
Investigational
Matched Description: … [A226305] Bulevirtide, also known as Hepcludex, is a first-in-class entry inhibitor for the treatment ... It was first approved for use in the EU on May 28, 2020; bulevirtide has been granted PRIME scheme eligibility ... [A226340,L30235] Until recently, there have been extremely limited treatments available for Hepatitis …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use …

Dimethyl sulfoxide

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including...
Approved
Vet approved
Matched Description: … Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application ... A highly polar organic liquid, that is used widely as a chemical solvent. ... Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Topical Products for Joint and Muscular Pain …

Minoxidil

A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Approved
Investigational
Matched Description: … and produces a fall in blood pressure. ... A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …
Matched Products: … Daylogic For Men ... Minoxidil for Men ... Renewal for Men …

Technetium Tc-99m sestamibi

Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six methoxyisobutylisonitrile (MIBI) ligands, hence the name sesta (6) MIBI.. Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by...
Approved
Investigational
Matched Description: … Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging ... Currently available within a preparation kit for injection, Technetium Tc 99m Sestamibi is indicated ... use in patient management decisions. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Kit for the Preparation of Technetium Tc99m Sestamibi …

Tixocortol

Tixocortol is a 21-thiol derivative of hydrocortisone classified as a class A corticosteroid. It is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid and mineralocorticoid activities and toxicity.
Approved
Withdrawn
Matched Description: … Tixocortol is a 21-thiol derivative of hydrocortisone classified as a class A corticosteroid. ... It is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid …

Drometrizole trisiloxane

Drometrizole trisiloxane is a photostable UVA and UVB light filter [A33069, L2780, L2781, L2782, L2783, F81]. The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia, and Japan, among other countries....
Approved
Matched Description: … with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia, and ... Drometrizole trisiloxane is a photostable UVA and UVB light filter [A33069, L2780, L2781, L2782, L2783 ... The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens …
Matched Mixtures name: … Kiehls Activated Sun Protector Sunscreen SPF 50 For Face and Body For All Skin Types ... Kiehls Activated Sun Protector Sunscreen SPF 30 For Face and Body For All Skin Types ... Anthelios XL Melt-IN Cream …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Nitroprusside

Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Approved
Investigational
Matched Description: … Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles ... Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Sodium Nitroprusside for Injection ... Sodium Nitroprusside In 0.9% Sodium Chloride …

Turoctocog alfa pegol

Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019. Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Description: … A as it ultimately provides a less burdensome and more convenient dosing regimen for patients that is ... factor VIII replacement therapy in patients with factor VIII deficiency, or hemophilia A [F3649]. ... 40-kDa polyethylene glycol (PEG) group to a specific _O_-glycan in the truncated B-domain of the general …

Viltolarsen

Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) is characterized by...
Approved
Investigational
Matched Description: … mutations allows for exon skipping, which retains a productive reading frame and results in the production ... dystrophin levels in skeletal muscle of patients treated with viltolarsen; this approval is contingent ... Viltolarsen is a phosphorodiamidate morpholino oligonucleotide (PMO); PMOs are oligonucleotides in which …

Poliovirus type 3 antigen (formaldehyde inactivated)

Poliovirus type 3 antigen is a suspension of poliovirus Type 3 (Saukett) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 3. The vaccine contains purified and inactivated poliovirus type 3 that were...
Approved
Investigational
Matched Description: … Poliovirus type 3 antigen is a suspension of poliovirus Type 3 (Saukett) used in the active immunization ... of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused ... The vaccine contains purified and inactivated poliovirus type 3 that were grown from a continuous line …
Matched Mixtures name: … -POLIO SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE ... Hexaxim Suspension for Injection ... BOOSTRIX POLIO SUSPENSION FOR INJECTION …
Displaying drugs 301 - 325 of 13635 in total