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Displaying drugs 51 - 75 of 215 in total

Fluorouracil

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Approved
Matched Salts name: … Fluorouracil sodium …
Matched Categories: … Fluorouracil and prodrugs ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …

Dextrothyroxine

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum...
Approved
Investigational
Matched Description: … Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory ... Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. ... Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines …
Matched Salts name: … Dextrothyroxine sodium …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Spironolactone

Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including...
Approved
Matched Description: … [A178192] It promotes sodium and water excretion and potassium retention. ... It binds to mineralocorticoid receptors and functions as aldosterone antagonists. ... [L44602] Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne …
Matched Mixtures name: … Spironolactone and Hydrochlorothiazide ... Spironolactone and Hydrochlorothiazide ... Spironolactone and Hydrochlorothiazide …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Canagliflozin

Canagliflozin, also known as Invokana, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018...
Approved
Matched Description: … Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in ... the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise ... It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 …
Matched Categories: … Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors ... Alimentary Tract and Metabolism ... metformin and canagliflozin …

Vutrisiran

Vutrisiran is a double-stranded small interfering ribonucleic acid (siRNA) that targets wild-type and mutant transthyretin (TTR) messenger RNA (mRNA). This siRNA therapeutic is indicated for the treatment of neuropathies associated with hereditary transthyretin-mediated amyloidosis (ATTR), a condition caused by mutations in the TTR gene. More than 130 TTR mutations have...
Approved
Investigational
Matched Description: … [A249010] TTR mutations lead to the formation of misfolded TTR proteins, which form amyloid fibrils ... [A249025,L42065] This delivery platform gives vutrisiran high potency and metabolic stability, and allows ... Vutrisiran is a double-stranded small interfering ribonucleic acid (siRNA) that targets wild-type and …
Matched Salts name: … Vutrisiran sodium …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Albuterol

Salbutamol (Albuterol [USAN]) is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a...
Approved
Vet approved
Matched Description: … Salbutamol is formulated as a racemic mixture of the R- and S-isomers. ... USAN]) is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and ... The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer …
Matched Mixtures name: … Ipratropium Bromide and Albuterol Sulfate ... Ipratropium Bromide and Albuterol Sulfate ... Ipratropium Bromide and Albuterol Sulfate …
Matched Categories: … salbutamol and sodium cromoglicate ... salbutamol and budesonide ... salbutamol and beclometasone ... salbutamol and ipratropium bromide …

Dronedarone

Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate control, rhythm control, prevention...
Approved
Matched Description: … [A186071] It meets criteria of all four Vaughan Williams antiarrhythmic drug classes by blocking sodium ... , potassium, and calcium ion channels and inhibiting β-adrenergic receptors. ... toxicities, such as thyroid and pulmonary toxicities. …

Dolutegravir

Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare...
Approved
Matched Description: … [A31342] Dolutegravir was developed by ViiV Healthcare and FDA-approved on August 12, 2013. ... The effect of this drug has no homology in human host cells, which gives it excellent tolerability and …
Matched Salts name: … Dolutegravir sodium …
Matched Categories: … lamivudine and dolutegravir ... dolutegravir and rilpivirine ... lamivudine, abacavir and dolutegravir ... lamivudine, tenofovir disoproxil and dolutegravir …

Estradiol

Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays, gels, and creams.[L11485,L11488,L11491,...
Approved
Investigational
Vet approved
Matched Description: … [DB00977] (EE) is a synthetic form of estradiol commonly used as the estrogenic component of most combination ... therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and ... forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays, gels, and …
Matched Mixtures name: … Estradiol and Progesterone ... Estradiol and Norethindrone Acetate ... Estradiol and Norethindrone Acetate …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Androgens and Estrogens ... Antiandrogens and Estrogens ... etynodiol and estrogen ... dienogest and estrogen …

Fosamprenavir

Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
Approved
Matched Salts name: … Fosamprenavir sodium …
Matched Categories: … Amprenavir and Prodrugs …

Angiotensin II

Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and Acute Renal Failure. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy. As of December 21, 2017 the FDA approved La Jolla Pharmaceutical's...
Approved
Investigational
Matched Description: … and death within hours, no matter young or o ld. ... , Renin Angiotensin System, and Idiopathic Membranous Nephropathy. ... Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Benzydamine

Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties. It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal system. Although the indazole analogue benzydamine is a...
Approved
Matched Description: … hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and ... It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal ... benzydamine is a non-steroidal anti-inflammatory drug (NSAID), it has various physicochemical properties and …
Matched Mixtures name: … Anti-inflammatory Lozenge (with antibacterial) (Eucalyptus and Menthol) ... Difflam plus ANAESTHETIC Sore Throat Lozenges (Sugar Free) Menthol and Eucalyptus Flavour …
Matched Categories: … Mouthwashes and Gargles ... Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain …

Finerenone

Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart attacks, and hospitalization due to heart failure in adults with chronic kidney disease associated with type II diabetes mellitus.[A236519,L34739] Patients with kidney...
Approved
Investigational
Matched Description: … [A236544] Spironolactone has low selectivity and affinity for the receptor; it dissociates quickly and ... [A236544] Eplerenone is more selective and has longer lasting effects. ... can also have effects at the androgen, progesterone, and glucocorticoid receptors. …

Chondroitin sulfate

Chondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA). The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a long-lasting effect after the end of the treatment. Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine...
Approved
Investigational
Nutraceutical
Matched Description: … [A7906] The SYSADOA status suggested a pain relief and increased joint mobility after a relative long ... Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic ... acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific …
Matched Mixtures name: … Blackmores Joint Formula with Glucosamine and Chondroitin …
Matched Salts name: … Chondroitin sulfate sodium (bovine) ... Chondroitin sulfate sodium (shark) ... Chondroitin sulfate sodium (chicken) ... Chondroitin sulfate sodium (porcine) …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Sodium phosphate, dibasic, unspecified form

Approved
Experimental
Matched Synonyms: … Sodium phosphate, dibasic, unspecified …
Matched Name: … Sodium phosphate, dibasic, unspecified form …
Matched Mixtures name: … Aminosyn II in Dextrose ... Up and Up Ready To Use Enema ... Pure and Gentle Laxative …

Potassium chloride

A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of...
Approved
Withdrawn
Matched Synonyms: … Chloride of potash ... Potassium chloride ... Monopotassium chloride …
Matched Name: … Potassium chloride …
Matched Iupac: … potassium chloride …
Matched Description: … chloride that supply 100 mg or more of potassium per dosage unit, except for controlled-release dosage ... The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium ... in fertilizers and explosives. …
Matched Mixtures name: … Potassium Chloride in Dextrose and Sodium Chloride ... Potassium Chloride in Dextrose and Sodium Chloride ... Potassium Chloride in Dextrose and Sodium Chloride …
Matched Categories: … potassium chloride ... potassium chloride ... Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... potassium chloride, combinations …
Matched Products: … Potassium Chloride ... Potrassium Chloride ... Potassium Chloride ER …

Sodium acetate

Sodium Acetate is chemically designated CH3COONa, a hygroscopic powder very soluble in water. Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in buffer solutions. Medically, sodium acetate is important component as an electrolyte replenisher when given intravenously. It is mainly indicated to correct...
Approved
Investigational
Matched Synonyms: … acetic acid, sodium salt ... anhydrous sodium acetate ... Sodium acetate anhydrous …
Matched Name: … Sodium acetate …
Matched Iupac: … sodium acetate …
Matched Description: … Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in ... It can be used also in metabolic acidosis and for urine alkalinization. ... It is mainly indicated to correct sodium levels in hyponatremic patients. …
Matched Mixtures name: … Plasma-Lyte 148 and dextrose ... Normosol-R and Dextrose ... Plasma-Lyte M and Dextrose …
Matched Salts name: … Sodium acetate trihydrate …
Matched Categories: … sodium acetate ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …
Matched Products: … Sodium Acetate ... Sodium Acetate Injection USP ... Sodium Acetate Injection, USP …

Sodium carbonate

Sodium Carbonate is the disodium salt of carbonic acid with alkalinizing property. When dissolved in water, sodium carbonate forms carbonic acid and sodium hydroxide. As a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid.
Approved
Matched Synonyms: … Anhydrous sodium carbonate ... Sodium carbonate anhydrous ... Carbonic acid sodium salt (1:2) …
Matched Name: … Sodium carbonate …
Matched Description: … When dissolved in water, sodium carbonate forms carbonic acid and sodium hydroxide. ... Sodium Carbonate is the disodium salt of carbonic acid with alkalinizing property. ... As a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid. …

Sodium borate

Approved
Experimental
Matched Synonyms: … Sodium borate anhydrous …
Matched Name: … Sodium borate …
Matched Salts name: … Sodium borate decahydrate …
Matched Categories: … sodium borate …
Matched Products: … Sodium Borate …

Indocyanine green acid form

Indocyanine Green is a water soluble, tricarbocyanine dye with a peak spectral absorption at 800 nm. The chemical name for Indocyanine Green is 1 H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e] indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-,hydroxide, inner salt, sodium salt. Indocyanine Green for Injection USP has a pH of approximately 6.5 when reconstituted. Each vial of Indocyanine Green for...
Approved
Investigational
Matched Name: … Indocyanine green acid form …
Matched Description: … 2H-benz[e] indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-,hydroxide, inner salt, sodium ... Injection USP contains 25 mg of Indocyanine Green as a sterile lyophilized powder with no more than 5% sodium …
Matched Products: … Spy Agent Green Kit for Advanced Imaging Modality (aim) and Pinpoint ... Spy Agent Green Lymphatics Kit for Advanced Imaging Modality (aim) and Pinpoint …

Sodium sulfide

Sodium sulfide is a chemical compound with a chemical formula Na2S. Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various chemical manufacturing processes including the production of rubber chemicals, sulfur dyes and oil recovery. Along with its hydrate form, sodium sulfide releases hydrogen...
Approved
Matched Name: … Sodium sulfide …
Matched Description: … Along with its hydrate form, sodium sulfide releases hydrogen sulfide (H2S) when in contact with moist ... Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various ... However the clinical significance and mechanism of action of sodium sulfide and replication of results …
Matched Products: … Sodium Sufide …

Liotrix

Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion....
Approved
Matched Synonyms: … Levothyroxine Sodium mixture with Liothyronine Sodium …
Matched Description: … It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in ... and combination hormone replacement therapy generally offers no therapeutic advantage. ... It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Kappadione

Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
Matched Synonyms: … Menadiol sodium diphosphate …
Matched Description: … by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not ... Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved …

Pegaptanib

Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. Pegaptanib was granted FDA approval on 17 September 2004.
Approved
Investigational
Matched Synonyms: … Pegaptanib sodium …
Matched Description: … neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Heparin

Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor...
Approved
Investigational
Matched Description: … coagulation enzymes thrombin (factor IIa) and factor Xa. ... UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. ... It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates …
Matched Mixtures name: … Heparin Sod and 0.9% Sod Chloride Inj ... Heparin Sodium and Dextrose 5% Inj USP ... Heparin Sodium In 0.9% Sodium Chloride Injection …
Matched Salts name: … Heparin sodium …
Matched Categories: … Heparin and similars ... Blood and Blood Forming Organs …
Matched Products: … Heparin Sodium and Dextrose ... Heparin Sodium and Sodium Chloride ... Heparin Sodium in Dextrose …
Displaying drugs 51 - 75 of 215 in total