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Identification
NameFosamprenavir
Accession NumberDB01319
TypeSmall Molecule
GroupsApproved
DescriptionFosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
Structure
Thumb
Synonyms
Fosamprenavir
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
LexivaSuspension50 mg/mLOralVii V Healthcare Company2010-10-04Not applicableUs
LexivaTablet, film coated700 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
LexivaTablet, film coated700 mg/1OralREMEDYREPACK INC.2011-11-11Not applicableUs
LexivaTablet, film coated700 mg/1OralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
LexivaTablet, film coated700 mg/1OralVii V Healthcare Company2010-10-04Not applicableUs
TelzirTablet, film coated700 mgOralVii V Healthcare Uk Limited 2004-07-12Not applicableEu
TelzirSuspension50 mg/mlOralVii V Healthcare Uk Limited 2004-07-12Not applicableEu
TelzirTablet700 mgOralViiv Healthcare Ulc2004-12-22Not applicableCanada
TelzirSuspension50 mgOralViiv Healthcare Ulc2005-02-23Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Fosamprenavir calcium
226700-81-8
Thumb
  • InChI Key: PMDQGYMGQKTCSX-HQROKSDRSA-L
  • Monoisotopic Mass: 623.1379288
  • Average Mass: 623.67
DBSALT001228
Categories
UNIIWOU1621EEG
CAS number226700-79-4
WeightAverage: 585.607
Monoisotopic: 585.190986967
Chemical FormulaC25H36N3O9PS
InChI KeyMLBVMOWEQCZNCC-OEMFJLHTSA-N
InChI
InChI=1S/C25H36N3O9PS/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32)/t21-,23-,24+/m0/s1
IUPAC Name
{[(2R,3S)-1-[N-(2-methylpropyl)4-aminobenzenesulfonamido]-3-({[(3S)-oxolan-3-yloxy]carbonyl}amino)-4-phenylbutan-2-yl]oxy}phosphonic acid
SMILES
CC(C)CN(C[C@@H](OP(O)(O)=O)[[email protected]](CC1=CC=CC=C1)NC(=O)O[[email protected]]1CCOC1)S(=O)(=O)C1=CC=C(N)C=C1
Pharmacology
IndicationIndicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV-1) infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially infectious body fluids of a person known to be infected with HIV when that exposure represents a substantial risk for HIV transmission. The use of fosamprenavir is pending revision due to a potential association between the drug and myocardial infarction and dyslipidemia in HIV infected adults.
Structured Indications
PharmacodynamicsFosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It has little or no antiviral activity until it is hydrolyzed by cellular phosphatases into amprenavir, which is the active ingredient. That metabolization increases the duration that amprenavir is available, making fosamprenavir a slow-release version of amprenavir and thus reducing the number of pills required versus standard amprenavir.
Mechanism of actionFosamprenavir is a prodrug that is rapidly hydrolyzed to amprenavir by cellular phosphatases in the gut epithelium as it is absorbed. Amprenavir is an inhibitor of HIV-1 protease. During HIV replication, HIV protease cleaves viral polypeptide products of the Gag and Gag-Pol genes to form structural proteins of the virion core and essential viral enzymes. Amprenavir interferes with this process by binding to the active site of HIV-1 protease, thereby preventing the processing of viral Gag and Gag-Pol polyprotein precursors, resulting in the formation of immature non-infectious viral particles.
TargetKindPharmacological actionActionsOrganismUniProt ID
Pol polyproteinProteinyes
inhibitor
Human immunodeficiency virus 1Q72874 details
Related Articles
AbsorptionThe absolute oral bioavailability of amprenavir after administration of fosamprenavir in humans has not been established. After administration of a single 1,400 mg dose in the fasted state, fosamprenavir oral suspension (50 mg/mL) and fosamprenavir tablets (700 mg) provided similar amprenavir exposures (AUC), however, the Cmax of amprenavir after administration of the suspension formulation was 14.5 % higher compared with the tablet.
Volume of distributionNot Available
Protein bindingVery high (approximately 90%); primarily bound to alpha 1 -acid glycoprotein. Higher amounts of unbound amprenavir present as amprenavir serum concentrations increase.
Metabolism

In the gut epithelium during absorption, fosamprenavir is rapidly and almost completely hydrolyzed to amprenavir and inorganic phosphate prior to reaching the systemic circulation. Amprenavir is metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system.

Route of eliminationExcretion of unchanged amprenavir in urine and feces is minimal. The renal elimination of unchanged amprenavir represents approximately 1% of the administered dose; therefore, renal impairment is not expected to significantly impact the elimination of amprenavir. Amprenavir, the active metabolite of fosamprenavir, is metabolized in the liver by the cytochrome P450 enzyme system.
Half lifeThe plasma elimination half-life of amprenavir (the active metabolite) is approximately 7.7 hours.
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Human Immunodeficiency Virus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Fosamprenavir.Approved, Investigational
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Fosamprenavir.Approved
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Fosamprenavir.Approved, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Fosamprenavir.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Fosamprenavir.Approved
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Fosamprenavir.Withdrawn
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Fosamprenavir.Approved
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Fosamprenavir.Experimental
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Fosamprenavir.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Fosamprenavir.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Fosamprenavir.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Fosamprenavir.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Fosamprenavir.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Fosamprenavir.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Fosamprenavir.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Fosamprenavir.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Fosamprenavir.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Fosamprenavir.Approved, Illicit, Investigational
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Fosamprenavir.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Fosamprenavir.Approved
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Fosamprenavir.Illicit, Withdrawn
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Fosamprenavir.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Fosamprenavir.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Fosamprenavir.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Fosamprenavir.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Fosamprenavir.Approved
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Fosamprenavir.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Fosamprenavir.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fosamprenavir.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Fosamprenavir.Approved, Investigational
AprepitantThe serum concentration of Fosamprenavir can be increased when it is combined with Aprepitant.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Fosamprenavir.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fosamprenavir.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Fosamprenavir.Approved
AsenapineThe serum concentration of Fosamprenavir can be decreased when it is combined with Asenapine.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Fosamprenavir.Approved, Withdrawn
AtazanavirThe metabolism of Fosamprenavir can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Fosamprenavir can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Fosamprenavir.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Fosamprenavir.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Fosamprenavir.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Fosamprenavir.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Fosamprenavir.Approved
BalaglitazoneThe therapeutic efficacy of Balaglitazone can be decreased when used in combination with Fosamprenavir.Investigational
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Fosamprenavir.Investigational
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Fosamprenavir.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Fosamprenavir.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Fosamprenavir.Approved
BexaroteneThe serum concentration of Fosamprenavir can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Fosamprenavir.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Fosamprenavir.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Fosamprenavir.Approved
BoceprevirThe serum concentration of Fosamprenavir can be decreased when it is combined with Boceprevir.Approved
BortezomibThe metabolism of Fosamprenavir can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Fosamprenavir can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fosamprenavir.Approved
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Fosamprenavir.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Fosamprenavir.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Fosamprenavir.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Fosamprenavir.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Fosamprenavir.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Fosamprenavir.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Fosamprenavir.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Fosamprenavir.Approved
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Fosamprenavir.Withdrawn
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Fosamprenavir.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Fosamprenavir.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Fosamprenavir.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Fosamprenavir.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Fosamprenavir.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Fosamprenavir.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Fosamprenavir.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Fosamprenavir.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Fosamprenavir.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Fosamprenavir.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Fosamprenavir.Approved
CarbamazepineThe metabolism of Fosamprenavir can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Fosamprenavir.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Fosamprenavir.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Fosamprenavir.Approved, Investigational
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Fosamprenavir.Experimental
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Fosamprenavir.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Fosamprenavir.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Fosamprenavir.Approved, Vet Approved
CeritinibThe serum concentration of Fosamprenavir can be increased when it is combined with Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Fosamprenavir.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Fosamprenavir.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Fosamprenavir.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Fosamprenavir.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Fosamprenavir.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Fosamprenavir.Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Fosamprenavir.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Fosamprenavir.Approved, Vet Approved
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Fosamprenavir.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Fosamprenavir.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Fosamprenavir.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Fosamprenavir.Approved, Investigational
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Fosamprenavir.Experimental
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Fosamprenavir.Approved
CimetidineThe serum concentration of Fosamprenavir can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Fosamprenavir.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Fosamprenavir.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be decreased when combined with Fosamprenavir.Approved
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Fosamprenavir.Approved
ClemastineThe metabolism of Fosamprenavir can be decreased when combined with Clemastine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Fosamprenavir.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Fosamprenavir.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Fosamprenavir.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Fosamprenavir.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Fosamprenavir.Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Fosamprenavir.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Fosamprenavir.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Fosamprenavir.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Fosamprenavir.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Fosamprenavir.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Fosamprenavir.Approved, Illicit
ClotrimazoleThe metabolism of Fosamprenavir can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Fosamprenavir.Approved
CobicistatThe metabolism of Fosamprenavir can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Fosamprenavir.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Fosamprenavir.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Fosamprenavir.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Fosamprenavir.Approved
ConivaptanThe serum concentration of Fosamprenavir can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Fosamprenavir.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Fosamprenavir.Approved
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Fosamprenavir.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Fosamprenavir.Approved
CyclophosphamideThe risk or severity of adverse effects can be increased when Fosamprenavir is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Fosamprenavir.Approved, Investigational, Vet Approved
CyclosporineThe metabolism of Fosamprenavir can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Fosamprenavir.Approved, Investigational
DabrafenibThe serum concentration of Fosamprenavir can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Fosamprenavir.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Fosamprenavir.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Fosamprenavir.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Fosamprenavir.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Fosamprenavir.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Fosamprenavir.Approved, Investigational
DarunavirThe metabolism of Fosamprenavir can be decreased when combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Fosamprenavir.Approved
DasatinibThe serum concentration of Fosamprenavir can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Fosamprenavir.Approved
DeferasiroxThe serum concentration of Fosamprenavir can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Fosamprenavir.Approved
DeoxyspergualinThe therapeutic efficacy of Deoxyspergualin can be decreased when used in combination with Fosamprenavir.Investigational
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Fosamprenavir.Approved
DesogestrelThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Desogestrel resulting in a loss in efficacy.Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Fosamprenavir.Approved
DexamethasoneThe serum concentration of Fosamprenavir can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Fosamprenavir.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Fosamprenavir.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Fosamprenavir.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Fosamprenavir.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Fosamprenavir.Approved
DienogestThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Dienogest resulting in a loss in efficacy.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Fosamprenavir.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Fosamprenavir.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Fosamprenavir.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Fosamprenavir.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Fosamprenavir.Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Fosamprenavir.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Fosamprenavir.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Fosamprenavir.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Fosamprenavir.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Fosamprenavir.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Fosamprenavir.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Fosamprenavir.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fosamprenavir.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Fosamprenavir.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Fosamprenavir.Approved
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Fosamprenavir.Approved
DoxepinThe serum concentration of Fosamprenavir can be decreased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Fosamprenavir.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Fosamprenavir.Approved, Investigational
DoxycyclineThe metabolism of Fosamprenavir can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Fosamprenavir.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Fosamprenavir.Approved
DrospirenoneThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Drospirenone resulting in a loss in efficacy.Approved
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Fosamprenavir.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Fosamprenavir.Approved, Investigational
EfavirenzThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Efavirenz resulting in a loss in efficacy.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Fosamprenavir.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Fosamprenavir.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Fosamprenavir.Approved
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Fosamprenavir.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Fosamprenavir.Approved, Vet Approved
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Fosamprenavir.Approved, Investigational
EnzalutamideThe serum concentration of Fosamprenavir can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Fosamprenavir can be decreased when it is combined with Epinastine.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Fosamprenavir.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Fosamprenavir.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Fosamprenavir.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Fosamprenavir.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Fosamprenavir.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Fosamprenavir.Approved, Investigational
ErythromycinThe metabolism of Fosamprenavir can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Fosamprenavir.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Fosamprenavir can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Fosamprenavir.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Fosamprenavir.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Fosamprenavir.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Fosamprenavir.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Fosamprenavir.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Fosamprenavir.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Fosamprenavir.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Fosamprenavir.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Fosamprenavir.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Fosamprenavir.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Fosamprenavir.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Fosamprenavir.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Fosamprenavir.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Fosamprenavir.Approved, Illicit
Ethynodiol diacetateThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Ethynodiol diacetate resulting in a loss in efficacy.Approved
EtonogestrelThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Etonogestrel resulting in a loss in efficacy.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Fosamprenavir.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Fosamprenavir.Approved, Investigational
EtravirineThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Fosamprenavir.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Fosamprenavir.Approved, Investigational
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Fosamprenavir.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Fosamprenavir.Approved
FamotidineThe serum concentration of Fosamprenavir can be decreased when it is combined with Famotidine.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Fosamprenavir.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Fosamprenavir.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Fosamprenavir.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Fosamprenavir.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe metabolism of Fesoterodine can be decreased when combined with Fosamprenavir.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Fosamprenavir.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Fosamprenavir.Approved, Investigational
FlecainideThe serum concentration of Flecainide can be increased when it is combined with Fosamprenavir.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Fosamprenavir.Approved
FluconazoleThe metabolism of Fosamprenavir can be decreased when combined with Fluconazole.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Fosamprenavir.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Fosamprenavir.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Fosamprenavir.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Fosamprenavir.Approved, Vet Approved
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Fosamprenavir.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Fosamprenavir.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Fosamprenavir.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Fosamprenavir.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Fosamprenavir.Approved
FluvoxamineThe metabolism of Fosamprenavir can be decreased when combined with Fluvoxamine.Approved, Investigational
FosaprepitantThe serum concentration of Fosamprenavir can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Fosamprenavir can be increased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Fosamprenavir.Approved, Investigational
Fusidic AcidThe serum concentration of Fosamprenavir can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Fosamprenavir.Approved
GarlicThe serum concentration of Fosamprenavir can be decreased when it is combined with Garlic.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Fosamprenavir.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Fosamprenavir.Approved
GestodeneThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Gestodene resulting in a loss in efficacy.Approved
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Fosamprenavir.Withdrawn
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Fosamprenavir.Approved
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Fosamprenavir.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Fosamprenavir.Approved
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Fosamprenavir.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Fosamprenavir.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Fosamprenavir.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Fosamprenavir.Withdrawn
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Fosamprenavir.Approved, Investigational
GusperimusThe therapeutic efficacy of Gusperimus can be decreased when used in combination with Fosamprenavir.Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Fosamprenavir.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Fosamprenavir.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Fosamprenavir.Approved, Vet Approved
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Fosamprenavir.Withdrawn
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Fosamprenavir.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Fosamprenavir.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Fosamprenavir.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Fosamprenavir.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Fosamprenavir.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Fosamprenavir.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Fosamprenavir.Approved
IdelalisibThe serum concentration of Fosamprenavir can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Fosamprenavir resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Fosamprenavir.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Fosamprenavir.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Fosamprenavir.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Fosamprenavir.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Fosamprenavir.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Fosamprenavir.Approved
IndinavirThe metabolism of Fosamprenavir can be decreased when combined with Indinavir.Approved
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Fosamprenavir.Approved
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Fosamprenavir.Approved
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Fosamprenavir.Approved
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Fosamprenavir.Approved
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Fosamprenavir.Approved
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Fosamprenavir.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Fosamprenavir.Approved
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Fosamprenavir.Approved, Investigational
IsavuconazoniumThe metabolism of Fosamprenavir can be decreased when combined with Isavuconazonium.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Fosamprenavir.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Fosamprenavir.Approved
IsradipineThe metabolism of Fosamprenavir can be decreased when combined with Isradipine.Approved
ItraconazoleThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Fosamprenavir.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Fosamprenavir.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Fosamprenavir.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Fosamprenavir.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Fosamprenavir.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Fosamprenavir.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Fosamprenavir.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Fosamprenavir.Approved
KetoconazoleThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Ketoconazole.Approved, Investigational
KetoconazoleThe metabolism of Fosamprenavir can be decreased when combined with Ketoconazole.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Fosamprenavir.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Fosamprenavir.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Fosamprenavir.Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Fosamprenavir.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Fosamprenavir.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Fosamprenavir.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Fosamprenavir.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Fosamprenavir.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Fosamprenavir.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Fosamprenavir.Approved
LevonorgestrelThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Levonorgestrel resulting in a loss in efficacy.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Fosamprenavir.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Fosamprenavir.Approved, Vet Approved
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Fosamprenavir.Approved
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Fosamprenavir.Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Fosamprenavir.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Fosamprenavir.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Fosamprenavir.Approved
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Fosamprenavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Fosamprenavir.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Fosamprenavir.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Fosamprenavir.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Fosamprenavir.Approved, Investigational
LuliconazoleThe serum concentration of Fosamprenavir can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Fosamprenavir can be increased when combined with Lumacaftor.Approved
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Fosamprenavir.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Fosamprenavir.Approved
LynestrenolThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Lynestrenol resulting in a loss in efficacy.Investigational
MacitentanThe metabolism of Macitentan can be decreased when combined with Fosamprenavir.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Fosamprenavir.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Fosamprenavir.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Medroxyprogesterone acetate resulting in a loss in efficacy.Approved, Investigational
MefloquineThe metabolism of Mefloquine can be decreased when combined with Fosamprenavir.Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Fosamprenavir.Approved, Vet Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Fosamprenavir.Approved
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Fosamprenavir.Approved
MethadoneThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Methadone resulting in a loss in efficacy.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Fosamprenavir.Experimental
MethanthelineThe serum concentration of Fosamprenavir can be decreased when it is combined with Methantheline.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Fosamprenavir.Illicit, Withdrawn
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Fosamprenavir.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Fosamprenavir.Approved, Vet Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Fosamprenavir.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Fosamprenavir.Approved
MetiamideThe serum concentration of Fosamprenavir can be decreased when it is combined with Metiamide.Experimental
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Fosamprenavir.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Fosamprenavir.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Fosamprenavir.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Fosamprenavir.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Fosamprenavir.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Fosamprenavir.Approved, Illicit
MifepristoneThe serum concentration of Fosamprenavir can be increased when it is combined with Mifepristone.Approved, Investigational
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Fosamprenavir.Approved
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Fosamprenavir.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Fosamprenavir.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Fosamprenavir.Approved
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Fosamprenavir.Approved, Investigational
MitotaneThe serum concentration of Fosamprenavir can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Fosamprenavir can be decreased when it is combined with Modafinil.Approved, Investigational
MontelukastThe metabolism of Montelukast can be decreased when combined with Fosamprenavir.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Fosamprenavir.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Fosamprenavir.Approved, Investigational
NafcillinThe serum concentration of Fosamprenavir can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fosamprenavir.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Fosamprenavir.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Fosamprenavir.Approved, Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Fosamprenavir.Approved, Withdrawn
NelfinavirThe metabolism of Fosamprenavir can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Fosamprenavir can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Nevirapine resulting in a loss in efficacy.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Fosamprenavir.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Fosamprenavir.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Fosamprenavir.Approved
NilotinibThe metabolism of Nilotinib can be decreased when combined with Fosamprenavir.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Fosamprenavir.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Fosamprenavir.Approved
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Fosamprenavir.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Fosamprenavir.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Fosamprenavir.Approved
NizatidineThe serum concentration of Fosamprenavir can be decreased when it is combined with Nizatidine.Approved
NorelgestrominThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Norelgestromin resulting in a loss in efficacy.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Fosamprenavir.Approved
NorgestimateThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Norgestimate resulting in a loss in efficacy.Approved
NorgestrelThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Norgestrel resulting in a loss in efficacy.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Fosamprenavir.Approved
OlanzapineThe serum concentration of Fosamprenavir can be decreased when it is combined with Olanzapine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Fosamprenavir.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Fosamprenavir.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Fosamprenavir.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Fosamprenavir.Approved
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Fosamprenavir.Investigational
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Fosamprenavir.Approved
OsimertinibThe serum concentration of Fosamprenavir can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Fosamprenavir.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Fosamprenavir.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Fosamprenavir.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Fosamprenavir is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Fosamprenavir.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Fosamprenavir.Approved, Vet Approved
PalbociclibThe serum concentration of Fosamprenavir can be increased when it is combined with Palbociclib.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Fosamprenavir.Approved, Investigational
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Fosamprenavir.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Fosamprenavir.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Fosamprenavir.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Fosamprenavir.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Fosamprenavir.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Fosamprenavir.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Fosamprenavir.Approved
ParoxetineThe serum concentration of Paroxetine can be decreased when it is combined with Fosamprenavir.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Fosamprenavir.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Fosamprenavir.Approved
PentobarbitalThe metabolism of Fosamprenavir can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Fosamprenavir.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Fosamprenavir.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Fosamprenavir.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Fosamprenavir.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Fosamprenavir.Approved
PethidineThe risk or severity of adverse effects can be increased when Fosamprenavir is combined with Pethidine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Fosamprenavir.Withdrawn
PhenforminThe therapeutic efficacy of Phenformin can be decreased when used in combination with Fosamprenavir.Approved, Withdrawn
PhenobarbitalThe metabolism of Fosamprenavir can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Fosamprenavir.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Fosamprenavir.Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Fosamprenavir.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Fosamprenavir.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Fosamprenavir.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Fosamprenavir.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Fosamprenavir.Withdrawn
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Fosamprenavir.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Fosamprenavir.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Fosamprenavir.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Fosamprenavir.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Fosamprenavir.Approved
PosaconazoleThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Posaconazole.Approved, Investigational, Vet Approved
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Fosamprenavir.Approved, Investigational
PrasteroneThe metabolism of Prasterone can be decreased when combined with Fosamprenavir.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Fosamprenavir.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Fosamprenavir.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Fosamprenavir.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Fosamprenavir.Approved, Vet Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Fosamprenavir.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Fosamprenavir.Approved, Vet Approved
PrimaquineThe metabolism of Primaquine can be decreased when combined with Fosamprenavir.Approved
PrimidoneThe metabolism of Fosamprenavir can be increased when combined with Primidone.Approved, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Fosamprenavir.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Fosamprenavir.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Fosamprenavir.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Fosamprenavir.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Fosamprenavir.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Fosamprenavir.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Fosamprenavir.Approved, Investigational
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Fosamprenavir.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Fosamprenavir.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Fosamprenavir.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Fosamprenavir.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Fosamprenavir.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Fosamprenavir.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Fosamprenavir.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Fosamprenavir.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Fosamprenavir.Approved, Investigational
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Fosamprenavir.Approved
RamelteonThe metabolism of Ramelteon can be decreased when combined with Fosamprenavir.Approved, Investigational
RanitidineThe serum concentration of Fosamprenavir can be decreased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Fosamprenavir.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Fosamprenavir.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Fosamprenavir.Approved
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Fosamprenavir.Approved, Investigational
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Fosamprenavir.Approved
RifabutinThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Fosamprenavir.Approved
RifampicinThe serum concentration of Fosamprenavir can be decreased when it is combined with Rifampicin.Approved
RifapentineThe metabolism of Fosamprenavir can be increased when combined with Rifapentine.Approved
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Fosamprenavir.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Fosamprenavir.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Fosamprenavir.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Fosamprenavir.Approved, Investigational
RitonavirThe metabolism of Fosamprenavir can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Fosamprenavir.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Fosamprenavir.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Fosamprenavir.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Fosamprenavir.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Fosamprenavir.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Fosamprenavir.Approved
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Fosamprenavir.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Fosamprenavir.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Fosamprenavir.Approved
Roxatidine acetateThe serum concentration of Fosamprenavir can be decreased when it is combined with Roxatidine acetate.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Fosamprenavir.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Fosamprenavir.Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Fosamprenavir.Approved
SaquinavirThe metabolism of Fosamprenavir can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Fosamprenavir.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Fosamprenavir.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Fosamprenavir.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Fosamprenavir.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Fosamprenavir.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Fosamprenavir.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Fosamprenavir.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Fosamprenavir.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Fosamprenavir.Approved, Investigational
SilodosinThe metabolism of Silodosin can be decreased when combined with Fosamprenavir.Approved
SiltuximabThe serum concentration of Fosamprenavir can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Fosamprenavir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Fosamprenavir.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Fosamprenavir.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Fosamprenavir.Approved, Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Fosamprenavir.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Fosamprenavir.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Fosamprenavir.Approved, Investigational
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Fosamprenavir.Approved
St. John's WortThe metabolism of Fosamprenavir can be increased when combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Fosamprenavir can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Fosamprenavir.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Fosamprenavir.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Fosamprenavir.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Fosamprenavir.Approved
SulfisoxazoleThe metabolism of Fosamprenavir can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Fosamprenavir.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Fosamprenavir.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Fosamprenavir.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Fosamprenavir.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Fosamprenavir.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Fosamprenavir.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Fosamprenavir.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Fosamprenavir.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Fosamprenavir.Approved, Investigational
TasosartanThe metabolism of Tasosartan can be decreased when combined with Fosamprenavir.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Fosamprenavir.Experimental
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Fosamprenavir.Approved
TelithromycinThe metabolism of Fosamprenavir can be decreased when combined with Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Fosamprenavir.Approved
TemsirolimusThe risk or severity of adverse effects can be increased when Fosamprenavir is combined with Temsirolimus.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Fosamprenavir.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Fosamprenavir.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Fosamprenavir.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Fosamprenavir.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Fosamprenavir.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Fosamprenavir.Approved, Vet Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Fosamprenavir.Approved
ThiazolidinedioneThe therapeutic efficacy of Thiazolidinedione can be decreased when used in combination with Fosamprenavir.Investigational
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Fosamprenavir.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Fosamprenavir.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Fosamprenavir.Approved
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Fosamprenavir.Approved
TiclopidineThe metabolism of Fosamprenavir can be decreased when combined with Ticlopidine.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Fosamprenavir.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Fosamprenavir.Approved
TipranavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Tipranavir.Approved, Investigational
TocilizumabThe serum concentration of Fosamprenavir can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Fosamprenavir.Approved, Investigational
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Fosamprenavir.Approved
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Fosamprenavir.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Fosamprenavir.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Fosamprenavir.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Fosamprenavir.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Fosamprenavir.Approved, Investigational
TramadolThe metabolism of Tramadol can be decreased when combined with Fosamprenavir.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Fosamprenavir.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Fosamprenavir.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Fosamprenavir.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Fosamprenavir.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Fosamprenavir.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Fosamprenavir.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Fosamprenavir.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Fosamprenavir.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Fosamprenavir.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Fosamprenavir.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Fosamprenavir.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Fosamprenavir.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Fosamprenavir.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Fosamprenavir.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Fosamprenavir.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Fosamprenavir.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Fosamprenavir.Approved
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Fosamprenavir.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Fosamprenavir.Approved
VenlafaxineThe metabolism of Fosamprenavir can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Fosamprenavir.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Fosamprenavir.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Fosamprenavir.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Fosamprenavir.Approved
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Fosamprenavir.Approved, Investigational
VinblastineThe metabolism of Vinblastine can be decreased when combined with Fosamprenavir.Approved
VincristineThe metabolism of Vincristine can be decreased when combined with Fosamprenavir.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Fosamprenavir.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Fosamprenavir.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Fosamprenavir.Approved
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Fosamprenavir.Approved, Investigational
VoriconazoleThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Fosamprenavir.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Fosamprenavir.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Fosamprenavir.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Fosamprenavir.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Fosamprenavir.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Fosamprenavir.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Fosamprenavir.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Fosamprenavir.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Fosamprenavir can be decreased when combined with Ziprasidone.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Fosamprenavir.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Fosamprenavir.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Fosamprenavir.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Fosamprenavir.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Fosamprenavir.Approved, Investigational
Food Interactions
  • Avoid alcohol, especially with the oral solution since it contains propylene glycol which competes with alcohol for alcohol dehydrogenase metabolism.
  • Take with or without food, however avoid lipid-rich meals.
  • Vitamin E increases fosamprenavir bioavailability.
References
Synthesis Reference

DrugSyn.org

US6559815
General References
  1. Smith KY, Weinberg WG, Dejesus E, Fischl MA, Liao Q, Ross LL, Pakes GE, Pappa KA, Lancaster CT: Fosamprenavir or atazanavir once daily boosted with ritonavir 100 mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT. AIDS Res Ther. 2008 Mar 28;5:5. doi: 10.1186/1742-6405-5-5. [PubMed:18373851 ]
  2. Hoffman RM, Umeh OC, Garris C, Givens N, Currier JS: Evaluation of sex differences of fosamprenavir (with and without ritonavir) in HIV-infected men and women. HIV Clin Trials. 2007 Nov-Dec;8(6):371-80. [PubMed:18042502 ]
  3. Chapman TM, Plosker GL, Perry CM: Fosamprenavir: a review of its use in the management of antiretroviral therapy-naive patients with HIV infection. Drugs. 2004;64(18):2101-24. [PubMed:15341507 ]
  4. Furfine ES, Baker CT, Hale MR, Reynolds DJ, Salisbury JA, Searle AD, Studenberg SD, Todd D, Tung RD, Spaltenstein A: Preclinical pharmacology and pharmacokinetics of GW433908, a water-soluble prodrug of the human immunodeficiency virus protease inhibitor amprenavir. Antimicrob Agents Chemother. 2004 Mar;48(3):791-8. [PubMed:14982766 ]
  5. Sension M: Initial therapy for human immunodeficiency virus: broadening the options. HIV Clin Trials. 2004 Mar-Apr;5(2):99-111. [PubMed:15116286 ]
  6. Wood R, Arasteh K, Stellbrink HJ, Teofilo E, Raffi F, Pollard RB, Eron J, Yeo J, Millard J, Wire MB, Naderer OJ: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients. Antimicrob Agents Chemother. 2004 Jan;48(1):116-23. [PubMed:14693528 ]
  7. Falcoz C, Jenkins JM, Bye C, Hardman TC, Kenney KB, Studenberg S, Fuder H, Prince WT: Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J Clin Pharmacol. 2002 Aug;42(8):887-98. [PubMed:12162471 ]
  8. Wire MB, Shelton MJ, Studenberg S: Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet. 2006;45(2):137-68. [PubMed:16485915 ]
External Links
ATC CodesJ05AE07
AHFS Codes
  • 08:18.08.08
PDB EntriesNot Available
FDA labelDownload (374 KB)
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6363
Blood Brain Barrier+0.5379
Caco-2 permeable+0.6992
P-glycoprotein substrateSubstrate0.6482
P-glycoprotein inhibitor IInhibitor0.7374
P-glycoprotein inhibitor IINon-inhibitor0.7819
Renal organic cation transporterNon-inhibitor0.8671
CYP450 2C9 substrateSubstrate0.5877
CYP450 2D6 substrateSubstrate0.6061
CYP450 3A4 substrateSubstrate0.5805
CYP450 1A2 substrateNon-inhibitor0.7454
CYP450 2C9 inhibitorNon-inhibitor0.6627
CYP450 2D6 inhibitorNon-inhibitor0.8835
CYP450 2C19 inhibitorNon-inhibitor0.6591
CYP450 3A4 inhibitorNon-inhibitor0.6317
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6969
Ames testNon AMES toxic0.598
CarcinogenicityNon-carcinogens0.78
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.5018 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9846
hERG inhibition (predictor II)Non-inhibitor0.8356
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tablet, film coatedOral700 mg/1
SuspensionOral50 mg
SuspensionOral50 mg/ml
TabletOral700 mg
Tablet, film coatedOral700 mg
Prices
Unit descriptionCostUnit
Lexiva 700 mg tablet14.78USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2224738 No2002-08-272016-06-28Canada
CA2231700 No2005-08-092018-03-10Canada
US6436989 Yes1998-06-242018-06-24Us
US6514953 Yes2000-01-152020-01-15Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.685 mg/mLALOGPS
logP0.84ALOGPS
logP1.92ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)1.22ChemAxon
pKa (Strongest Basic)2.45ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area177.72 Å2ChemAxon
Rotatable Bond Count13ChemAxon
Refractivity144.95 m3·mol-1ChemAxon
Polarizability57.77 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentAminobenzenesulfonamides
Alternative Parents
Substituents
  • Phenylbutylamine
  • Aminobenzenesulfonamide
  • Sulfonylaniline
  • Amphetamine or derivatives
  • Substituted aniline
  • Phosphoethanolamine
  • Monoalkyl phosphate
  • Aniline
  • Alkyl phosphate
  • Primary aromatic amine
  • Phosphoric acid ester
  • Organic phosphoric acid derivative
  • Organic phosphate
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Oxolane
  • Oxacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Primary amine
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human immunodeficiency virus 1
Pharmacological action
yes
Actions
inhibitor
General Function:
Aspartic-type endopeptidase activity
Specific Function:
Not Available
Gene Name:
pol
Uniprot ID:
Q72874
Molecular Weight:
10778.7 Da
References
  1. Hoffman RM, Umeh OC, Garris C, Givens N, Currier JS: Evaluation of sex differences of fosamprenavir (with and without ritonavir) in HIV-infected men and women. HIV Clin Trials. 2007 Nov-Dec;8(6):371-80. [PubMed:18042502 ]
  2. Furfine ES, Baker CT, Hale MR, Reynolds DJ, Salisbury JA, Searle AD, Studenberg SD, Todd D, Tung RD, Spaltenstein A: Preclinical pharmacology and pharmacokinetics of GW433908, a water-soluble prodrug of the human immunodeficiency virus protease inhibitor amprenavir. Antimicrob Agents Chemother. 2004 Mar;48(3):791-8. [PubMed:14982766 ]
  3. Sension M: Initial therapy for human immunodeficiency virus: broadening the options. HIV Clin Trials. 2004 Mar-Apr;5(2):99-111. [PubMed:15116286 ]
  4. Wood R, Arasteh K, Stellbrink HJ, Teofilo E, Raffi F, Pollard RB, Eron J, Yeo J, Millard J, Wire MB, Naderer OJ: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients. Antimicrob Agents Chemother. 2004 Jan;48(1):116-23. [PubMed:14693528 ]
  5. Wire MB, Shelton MJ, Studenberg S: Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet. 2006;45(2):137-68. [PubMed:16485915 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Wire MB, Shelton MJ, Studenberg S: Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet. 2006;45(2):137-68. [PubMed:16485915 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
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Drug created on June 30, 2007 11:17 / Updated on December 08, 2016 11:46