Displaying drugs 26 - 50 of 552 in total
Silver sulfadiazine
Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.
Approved
Vet approved
Matched International brands: … Silverol …
Matched Synonyms: … Silver sulfadiazine ... Silver sulfadiazinate ... Sulfadiazine silver …
Matched Name: … Silver sulfadiazine …
Matched Iupac: … silver(1+) 4-{[(pyrimidin-2-yl)azanidyl]sulfonyl}aniline …
Matched Description: … Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree …
Matched Mixtures name: … SILVIN CREAM …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... silver sulfadiazine ... silver sulfadiazine, combinations …
Matched Products: … Silver Sulfadiazine ... Silver Sulfadiazene ... SULFADIAZINE SILVER …
Matched Synonyms: … Silver sulfadiazine ... Silver sulfadiazinate ... Sulfadiazine silver …
Matched Name: … Silver sulfadiazine …
Matched Iupac: … silver(1+) 4-{[(pyrimidin-2-yl)azanidyl]sulfonyl}aniline …
Matched Description: … Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree …
Matched Mixtures name: … SILVIN CREAM …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... silver sulfadiazine ... silver sulfadiazine, combinations …
Matched Products: … Silver Sulfadiazine ... Silver Sulfadiazene ... SULFADIAZINE SILVER …
Econazole
A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally.
Approved
Matched Description: … It is used topically in dermatomycoses also orally and parenterally. …
Matched Mixtures name: … Econazole Nitrate 1% / Niacinamide 4% ... 071023 Econazole Nitrate 1% / Niacinamide 4% …
Matched Salts name: … Econazole nitrate …
Matched Categories: … Imidazole and Triazole Derivatives ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Metabolic Side Effects of Drugs and Substances ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Econazole Nitrate ... Econazole Nitrate Cream ... Econazole Nitrate Topical Foam, 1% …
Matched Mixtures name: … Econazole Nitrate 1% / Niacinamide 4% ... 071023 Econazole Nitrate 1% / Niacinamide 4% …
Matched Salts name: … Econazole nitrate …
Matched Categories: … Imidazole and Triazole Derivatives ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Metabolic Side Effects of Drugs and Substances ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Econazole Nitrate ... Econazole Nitrate Cream ... Econazole Nitrate Topical Foam, 1% …
Pectin
Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants. It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4. The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts or...
Approved
Investigational
Vet approved
Matched Description: … carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium …
Matched Mixtures name: … Kaolin and Pectin Susp ... Cepacol Sore Throat and Coating ... Sucrets Complete Sore Throat, Cough and Irritation …
Matched Categories: … Alimentary Tract and Metabolism ... Diet, Food, and Nutrition …
Matched Products: … Ludens Honey and Berry ... Throat Coat Lemon Ginger Echinacea …
Matched Mixtures name: … Kaolin and Pectin Susp ... Cepacol Sore Throat and Coating ... Sucrets Complete Sore Throat, Cough and Irritation …
Matched Categories: … Alimentary Tract and Metabolism ... Diet, Food, and Nutrition …
Matched Products: … Ludens Honey and Berry ... Throat Coat Lemon Ginger Echinacea …
N-Alkyl dimethyl benzyl ammonium chloride (C12-C18)
Experimental
Matched Synonyms: … (C12-C18) Alkyldimethylbenzyl ammonium chloride ... (C12-C18)Alkylbenzyldimethylammonium chloride ... (C12-C18)Alkyldimethylbenzylammonium chloride …
Matched Name: … N-Alkyl dimethyl benzyl ammonium chloride (C12-C18) …
Matched Iupac: … benzyldimethyltetradecylazanium chloride …
Matched Name: … N-Alkyl dimethyl benzyl ammonium chloride (C12-C18) …
Matched Iupac: … benzyldimethyltetradecylazanium chloride …
SP1049C
SP1049C is a novel anthracycline chemotherapeutic agent containing doxorubicin and two nonionic pluronic block copolymers. It is designed to overcome drug resistance in a number of cancers. It has successfully completed Phase 1 trials. Phase 2 results are currently under final review. Preliminary data, in its first clinically tested indication,...
Investigational
Matched Synonyms: … doxorubicin with pluronics F-127 and L-61 ... Doxorubicin HCl with pluronic L-61 and pluronic F-127 …
Matched Description: … Median survival is encouraging and correlates strongly with dose levels.[A260416] ... SP1049C is a novel anthracycline chemotherapeutic agent containing [doxorubicin] and two nonionic pluronic …
Matched Description: … Median survival is encouraging and correlates strongly with dose levels.[A260416] ... SP1049C is a novel anthracycline chemotherapeutic agent containing [doxorubicin] and two nonionic pluronic …
Echinacea purpurea
Approved
Experimental
Matched Synonyms: … Echinacea whole ... Echinacea intermedia whole ... Echinacea purpurea whole …
Matched Name: … Echinacea purpurea …
Matched Mixtures name: … Echinacea/golden Seal Cold Formula …
Matched Categories: … Herbs and Natural Products …
Matched Products: … Adult Echinacea Purpurea ... Echinacea Purpurea Root ... Echinacea Purpurea 333mg …
Matched Name: … Echinacea purpurea …
Matched Mixtures name: … Echinacea/golden Seal Cold Formula …
Matched Categories: … Herbs and Natural Products …
Matched Products: … Adult Echinacea Purpurea ... Echinacea Purpurea Root ... Echinacea Purpurea 333mg …
Losartan
Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo...
Approved
Matched Description: … potassium and hydrochlorothiazide. ... [L7423,L7426] Patients taking losartan should have their renal function and potassium levels monitored ... [L7423] Losartan is available as losartan potassium oral tablets as well as a combination tablet of losartan …
Matched Mixtures name: … Losartan Potassium and Hydrochlorothiazide ... Losartan Potassium and Hydrochlorothiazide ... Losartan Potassium and Hydrochlorothiazide …
Matched Salts name: … Losartan potassium …
Matched Categories: … losartan and diuretics ... losartan and amlodipine ... Angiotensin II receptor blockers (ARBs) and diuretics ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers …
Matched Products: … Losartan Potassium ... Losortan Potassium ... Losartan Potatssium …
Matched Mixtures name: … Losartan Potassium and Hydrochlorothiazide ... Losartan Potassium and Hydrochlorothiazide ... Losartan Potassium and Hydrochlorothiazide …
Matched Salts name: … Losartan potassium …
Matched Categories: … losartan and diuretics ... losartan and amlodipine ... Angiotensin II receptor blockers (ARBs) and diuretics ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers …
Matched Products: … Losartan Potassium ... Losortan Potassium ... Losartan Potatssium …
Benzylpenicillin
Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms.
Natural penicillins are considered...
Approved
Vet approved
Matched Description: … Resistance patterns, susceptibility and treatment guidelines vary across regions. ... by susceptible gram positive aerobic organisms, such as *Streptococcus pneumoniae*, groups A, B, C and ... G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase …
Matched Salts name: … Benzylpenicillin potassium …
Matched Products: … Penicillin G Potassium ... BENZILPENICILLINA POTASSICA ... Buffered Penicillin G Potassium …
Matched Salts name: … Benzylpenicillin potassium …
Matched Products: … Penicillin G Potassium ... BENZILPENICILLINA POTASSICA ... Buffered Penicillin G Potassium …
PlasmaCord
PlasmaCord is platelet-poor plasma that is derived by fractionation from sterile umbilical cord and placental blood. It is developed by Cellpraxis and is currently being investigated against severe acute respiratory syndrome (SARS).
Investigational
Matched Synonyms: … Human umbilical cord and placental blood plasma …
Matched Description: … PlasmaCord is platelet-poor plasma that is derived by fractionation from sterile umbilical cord and placental ... [L27581] It is developed by Cellpraxis and is currently being investigated against severe acute respiratory …
Matched Description: … PlasmaCord is platelet-poor plasma that is derived by fractionation from sterile umbilical cord and placental ... [L27581] It is developed by Cellpraxis and is currently being investigated against severe acute respiratory …
Silver proteinate
Experimental
Matched Synonyms: … Silver protein ... Proteinated silver …
Matched Name: … Silver proteinate …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Name: … Silver proteinate …
Matched Categories: … Amino Acids, Peptides, and Proteins …
NeuroCell-PD
Investigational
Matched Synonyms: … Porcine fetal neural dopaminergic cells and/or precursors aseptically prepared and coated with anti-MHC …
VA-MENGOC-BC®
VA-MENGOC-BC is a meningococcal B and C vaccine and an outer membrane vesicle (OMV)-based vaccine. The OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide of meningococcal group C. As there already exists a polysaccharide-based vaccine against meningococcal disease originating from serogroups A,C,W135, and...
Investigational
Matched Synonyms: … Meningococcal polysaccharide vaccine groups B and C …
Matched Description: … VA-MENGOC-BC is a meningococcal B and C vaccine and an outer membrane vesicle (OMV)-based vaccine. ... The OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide ... Y, this vaccine was created for use against serogroups B and C. …
Matched Description: … VA-MENGOC-BC is a meningococcal B and C vaccine and an outer membrane vesicle (OMV)-based vaccine. ... The OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide ... Y, this vaccine was created for use against serogroups B and C. …
Oxiconazole
Oxiconazole is an antifungal agent that is commonly found in topical formulations. It is marketed under the brand names Oxistat and Oxistat, and is used in the treatment of various skin infections such as athlete's foot, jock itch and ringworm.
Approved
Matched Description: … It is marketed under the brand names Oxistat and Oxistat, and is used in the treatment of various skin ... infections such as athlete's foot, jock itch and ringworm. …
Matched Salts name: … Oxiconazole nitrate …
Matched Categories: … Imidazole and Triazole Derivatives ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Products: … Oxiconazole Nitrate ... Oxiconazole Nitrate Cream 1% …
Matched Salts name: … Oxiconazole nitrate …
Matched Categories: … Imidazole and Triazole Derivatives ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Products: … Oxiconazole Nitrate ... Oxiconazole Nitrate Cream 1% …
Octasulfur
Sulfur is a chemical element that is present in all living tissues. The most commonly used form of pharmaceutical sulfur is Octasulfur (S8). After calcium and phosphorus, it is the third most abundant mineral in the human body. Sulfur is also found in garlic, onions and broccoli.
People take sulfur...
Approved
Matched Description: … Sulfur is also found in garlic, onions and broccoli. ... After calcium and phosphorus, it is the third most abundant mineral in the human body. ... allergies, swelling in the back of the throat (pharyngitis), high cholesterol, clogged arteries, menopause, and …
Matched Mixtures name: … ZOLFO E POTASSIO CARBONATO NEW.FA.DEM. ... ZOLFO E POTASSIO CARBONATO NEW.FA.DEM. ... Sodium Sulfacetamide and Sulfur 10 Percent and 5 Percent Cleanser …
Matched Products: … SLMD Silver Sulfur Acne Cream ... Sodium Sulfacetamide and Sulfur ... Malin and Goetz Acne Treatment …
Matched Mixtures name: … ZOLFO E POTASSIO CARBONATO NEW.FA.DEM. ... ZOLFO E POTASSIO CARBONATO NEW.FA.DEM. ... Sodium Sulfacetamide and Sulfur 10 Percent and 5 Percent Cleanser …
Matched Products: … SLMD Silver Sulfur Acne Cream ... Sodium Sulfacetamide and Sulfur ... Malin and Goetz Acne Treatment …
AFM-13
Investigational
Matched Synonyms: … Recombinant antibody construct against human CD30 and CD16A …
Mercuric chloride
Mercury chloride (HgCl2) is a highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant. Mercuric chloride was used to disinfect wounds by Arab physicians in the Middle Ages but modern...
Experimental
Matched Synonyms: … chlorure mercurique ... Mercuric chloride ... Mercury(II) chloride …
Matched Name: … Mercuric chloride …
Matched Description: … Mercury chloride (HgCl2) is a highly toxic compound that volatizes slightly at ordinary temperature and ... It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant. ... Mercuric chloride was used to disinfect wounds by Arab physicians in the Middle Ages but modern medicine …
Matched Categories: … Antiseptics and Disinfectants ... Chlorides ... Chlorine Compounds ... mercuric chloride …
Matched Name: … Mercuric chloride …
Matched Description: … Mercury chloride (HgCl2) is a highly toxic compound that volatizes slightly at ordinary temperature and ... It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant. ... Mercuric chloride was used to disinfect wounds by Arab physicians in the Middle Ages but modern medicine …
Matched Categories: … Antiseptics and Disinfectants ... Chlorides ... Chlorine Compounds ... mercuric chloride …
Potassium gluconate
Potassium gluconate is a salt of DB01345 and is classified as a food additive by the FDA . It is also used as a potassium supplement .
Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining...
Approved
Matched Synonyms: … Potassium gluconate ... potassium D-gluconate …
Matched Name: … Potassium gluconate …
Matched Iupac: … potassium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate …
Matched Description: … Potassium gluconate is believed to be more palatable and non-acidifying than potassium chloride (KCl) ... Potassium gluconate is a salt of [DB01345] and is classified as a food additive by the FDA [L2654]. ... potassium citrate, phosphate, aspartate, bicarbonate, and **gluconate**—are also used [L2652]. …
Matched Mixtures name: … Iode-potassium ... Potassium W Folic Acid Tab ... Cal-mag Plus K, Mn and Zn Caplets …
Matched Categories: … Alimentary Tract and Metabolism ... Potassium Salt ... potassium gluconate …
Matched Products: … Potassium Tab 8.3mg ... Potassium Rougier ... Potassium Tab 99mg …
Matched Name: … Potassium gluconate …
Matched Iupac: … potassium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate …
Matched Description: … Potassium gluconate is believed to be more palatable and non-acidifying than potassium chloride (KCl) ... Potassium gluconate is a salt of [DB01345] and is classified as a food additive by the FDA [L2654]. ... potassium citrate, phosphate, aspartate, bicarbonate, and **gluconate**—are also used [L2652]. …
Matched Mixtures name: … Iode-potassium ... Potassium W Folic Acid Tab ... Cal-mag Plus K, Mn and Zn Caplets …
Matched Categories: … Alimentary Tract and Metabolism ... Potassium Salt ... potassium gluconate …
Matched Products: … Potassium Tab 8.3mg ... Potassium Rougier ... Potassium Tab 99mg …
Petrolatum
A colloidal system of semisolid hydrocarbons obtained from petroleum. It is used as an ointment base, topical protectant, and lubricant.
Approved
Investigational
Matched Description: … It is used as an ointment base, topical protectant, and lubricant. …
Matched Mixtures name: … A and D Diaper Rash and Skin Protectant ... Vitamin A and D ... Vitamin A and D …
Matched Categories: … Basic Ointments and Protectants …
Matched Products: … Resurfix Elemental Silver Healing ... Procurevitamin A and D Vitamin A and D ... ProcureVITAMIN A AND D VITAMIN A AND D …
Matched Mixtures name: … A and D Diaper Rash and Skin Protectant ... Vitamin A and D ... Vitamin A and D …
Matched Categories: … Basic Ointments and Protectants …
Matched Products: … Resurfix Elemental Silver Healing ... Procurevitamin A and D Vitamin A and D ... ProcureVITAMIN A AND D VITAMIN A AND D …
Efprezimod alfa
CD24Fc is a biological immunomodulator originally developed to address graft-versus-host disease in stem cell transplantation in leukemia patients.
Investigational
Matched Synonyms: … Human CD24 and human IgG Fc Fusion Protein …
Pyrithione
Pyrithione zinc, or zinc pyrithione or zinc pyridinethione, is a coordination complex consisted of pyrithione ligands chelated to zinc (2+) ions via oxygen and sulfur centers. In the crystalline state, it exists as a centrosymmetric dimer. Due to its dynamic fungistatic and bacteriostatic properties, pyrithione zinc is used to treat...
Approved
Matched Description: … and seborrheic dermatitis. ... of proteins essential for fungal metabolism and growth [A27132]. ... by fungi such as _Malassezia globosa_ and _M. restricta_ [A32162]. …
Matched Mixtures name: … Head and Shoulders Dual Sachets Full and Strong ... Head and Shoulders Dual Sachets Full and Strong ... Head and Shoulders Dual Sachets Smooth and Silky …
Matched Products: … Silver Plus ... Jhirmack Distinctions Silver Plus Dandruff ... Head and Shoulders smooth and silky …
Matched Mixtures name: … Head and Shoulders Dual Sachets Full and Strong ... Head and Shoulders Dual Sachets Full and Strong ... Head and Shoulders Dual Sachets Smooth and Silky …
Matched Products: … Silver Plus ... Jhirmack Distinctions Silver Plus Dandruff ... Head and Shoulders smooth and silky …
Aluminum zirconium octachlorohydrex gly
Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent , . It diffuses into the sweat pores and prevents perspiration (sweat) from leaving the pores. The anhydrous form of the compound also has water-absorbing properties. Currently, the FDA allows...
Approved
Matched Iupac: … zirconium(4+) aluminium(3+) 2-aminoacetate dihydrate chloride …
Matched Description: … It diffuses into the sweat pores and prevents perspiration (sweat) from leaving the pores. ... Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and …
Matched Mixtures name: … Lactovit DEODORANT AND ANTIPERSPIRANT INVISIBLE ANTISTAIN …
Matched Products: … Cremo Anti-Perspirant Deodorant Silver Water and Birch ... Dove Men plus Care Cool Silver Antiperspirant and Deodorant ... Cremo Antiperspirant Silver Water …
Matched Description: … It diffuses into the sweat pores and prevents perspiration (sweat) from leaving the pores. ... Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and …
Matched Mixtures name: … Lactovit DEODORANT AND ANTIPERSPIRANT INVISIBLE ANTISTAIN …
Matched Products: … Cremo Anti-Perspirant Deodorant Silver Water and Birch ... Dove Men plus Care Cool Silver Antiperspirant and Deodorant ... Cremo Antiperspirant Silver Water …
Sodium fluorophosphate
Sodium monofluorophosphate is used in OTC dental preparations to help protect against cavities.
Approved
Matched Mixtures name: … Mentadent Specialty Whitening Toothpaste and Polishing ... Hawaiian Airline EC with Colgate Toothbrush and Sun ... Nano Silver Toothpaste …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Finefra Silver ... Far Infra Silver ... Schmidts MINT and BERRY KIDS TOOTH AND MOUTH …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Finefra Silver ... Far Infra Silver ... Schmidts MINT and BERRY KIDS TOOTH AND MOUTH …
Hydroquinone
Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids,...
Approved
Investigational
Matched Description: … As a result of these concerns, hydroquinone has been banned in the EU and UK. ... Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration ... with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and …
Matched Mixtures name: … OLIVIA QUIDO FIRM and FADE I ... OLIVIA QUIDO FIRM and FADE II ... Condition and Enhance System Travel-size Surgical …
Matched Products: … Gold Cosmetics Bleach Cream Silver ... CONDITION AND ENHANCE CLEAR Skin Bleaching and Corrector ... CONDITION AND ENHANCE BLENDER Skin Lightener and Blending …
Matched Mixtures name: … OLIVIA QUIDO FIRM and FADE I ... OLIVIA QUIDO FIRM and FADE II ... Condition and Enhance System Travel-size Surgical …
Matched Products: … Gold Cosmetics Bleach Cream Silver ... CONDITION AND ENHANCE CLEAR Skin Bleaching and Corrector ... CONDITION AND ENHANCE BLENDER Skin Lightener and Blending …
Menthol
Approved
Matched Mixtures name: … Silvera Pain Relief Patch ... Benzocaine, Menthol, Zinc Chloride ... Benzocaine, Menthol, Zinc Chloride …
Matched Products: … Natural Honey Lemon with Echinacea Cough Suppressant Throat Drops ... Sugar Free Green Tea With Echinacea Cough Suppressant Throat Drops ... Muscle and Joint …
Matched Products: … Natural Honey Lemon with Echinacea Cough Suppressant Throat Drops ... Sugar Free Green Tea With Echinacea Cough Suppressant Throat Drops ... Muscle and Joint …
Aluminum chlorohydrate
Aluminum chlorohydrate is a group of water-soluble aluminum complexes with the general formula AlnCl(3n-m)(OH)m. It is included up to 25% in over-the-counter hygiene products as an active antiperspirant agent. The primary site of action of aluminum chlorohydrate is at the level of the stratum corneum layer, which is relatively near...
Approved
Matched Iupac: … dialuminium(3+) ion hydrate chloride pentahydroxide …
Matched Categories: … Astringents and Deodorants ... Drugs Affecting Bone Structure and Mineralization …
Matched Products: … Silver Leather ... Dove Men plus Care Cool Silver Antiperspirant ... Soft and Dri Cool and Clean …
Matched Categories: … Astringents and Deodorants ... Drugs Affecting Bone Structure and Mineralization …
Matched Products: … Silver Leather ... Dove Men plus Care Cool Silver Antiperspirant ... Soft and Dri Cool and Clean …
Displaying drugs 26 - 50 of 552 in total