Showing drug card for Chlorphenesin (DB00856)
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| Version | 2.5 |
| Creation Date | 2005-06-13 13:24:05 |
| Update Date | 2009-04-16 16:48:05 |
| Primary Accession Number | DB00856 |
| Secondary Accession Number |
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| Name | Chlorphenesin |
| Drug Type |
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| Description | A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203) |
| Synonyms |
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| Brand Names |
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| Chemical IUPAC Name | 3-(4-chlorophenoxy)propane-1,2-diol |
| Chemical Formula | C9H11ClO3 |
| Chemical Structure | |
| CAS Registry Number | 104-29-0 |
| InChI Identifier | InChI=1/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2 |
| InChI Key | MXOAEAUPQDYUQM-UHFFFAOYAS |
| KEGG Drug | Not Available |
| KEGG Compound | C07928  |
| PubChem Compound | 7697 |
| PubChem Substance | 10130 |
| ChEBI ID | Not Available |
| PharmGKB ID | PA448958 |
| HET ID | Not Available |
| GenBank ID | Not Available |
| Drug ID Number [DIN] | 02091496 |
| RxList Link | Not Available |
| PDRhealth Link | Not Available |
| Wikipedia Link | Not Available |
| FDA Label | Not Available |
| Material Safety Data Sheet (MSDS) | |
| Synthesis Reference | Not Available |
| Average Molecular Weight | 202.6350 |
| Monoisotopic Molecular Weight | 202.0397 |
| State | Solid |
| Melting Point | 78 oC |
| Experimental Water Solubility | 1E+004 mg/L Source: PhysProp |
| Predicted Water Solubility | 1.04e+01 mg/mL Calculated using ALOGPS |
| Experimental LogP/Hydrophobicity | 1.2 Source: PhysProp |
| Predicted LogP | 1.46 Calculated using ALOGPS |
| Experimental LogS | Not Available |
| Predicted LogS | -1.29 Calculated using ALOGPS |
| Experimental Caco2 Permeability | Not Available |
| pKa/Isoelectric Point | Not Available |
| Mass Spectrum | Not Available |
| MOL File | Show | Download |
| SDF File | Show | Download |
| PDB File | Show | Download |
| 2D Structure | |
| 3D Structure | |
| Experimental PDB ID | Not Available |
| Isomeric SMILES | OC[C@@H](O)COC1=CC=C(Cl)C=C1 |
| Canonical SMILES | OCC(O)COC1=CC=C(Cl)C=C1 |
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| AHFS Codes | Not Available |
| Indication | Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. |
| Pharmacology | Chlorphenesin is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. |
| Mechanism of Action | The mechanism of action of chlorphenesin is not well defined, and its effects are measured mainly by subjective responses. It is known that chlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle. |
| Absorption | Rapid and complete. |
| Toxicity | Symptoms of a chlorphenesin overdose include drowsiness and nausea. |
| Protein Binding | Not Available |
| Biotransformation | Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite. |
| Half Life | 2.3-5 hours |
| Dosage Forms | Not Available |
| Patient Information | Not Available |
| Contraindications | Not Available |
| Interactions | Not Available |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
| Pathways | Not Available |
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