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Identification
NameFlavin adenine dinucleotide
Accession NumberDB03147  (EXPT01391)
Typesmall molecule
Groupsapproved
Description

A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
Flavin adenine dinucleotide is approved for use in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency.

Structure
Thumb
Synonyms
SynonymLanguageCode
FADNot AvailableNot Available
Salts
Name/CAS Structure Properties
Flavin adenine dinucleotide sodium
Thumb Not applicable DBSALT000903
Brand names
NameCompany
AdeflavinNot Available
FlazirenNot Available
Brand mixturesNot Available
CategoriesNot Available
CAS number146-14-5
WeightAverage: 785.5497
Monoisotopic: 785.157134455
Chemical FormulaC27H33N9O15P2
InChI KeyVWWQXMAJTJZDQX-UYBVJOGSSA-N
InChI
InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1
IUPAC Name
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy})phosphinic acid
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2
Mass SpecNot Available
Taxonomy
KingdomOrganic Compounds
SuperclassOrganooxygen Compounds
ClassCarbohydrates and Carbohydrate Conjugates
SubclassGlycosyl Compounds
Direct parentFlavin Nucleotides
Alternative parentsPurine Ribonucleoside Diphosphates; Flavins; Pentose Phosphates; Quinoxalines; Organic Pyrophosphates; Monosaccharide Phosphates; Purines and Purine Derivatives; Toluenes; Pyrimidones; Aminopyrimidines and Derivatives; Pyrazines; N-substituted Imidazoles; Organophosphate Esters; Primary Aromatic Amines; Organic Phosphoric Acids; Oxolanes; Tetrahydrofurans; Secondary Alcohols; 1,2-Diols; Polyamines; Ethers
Substituentspurine ribonucleoside diphosphate; flavin; isoalloxazine; pentose-5-phosphate; pentose phosphate; quinoxaline; pteridine; organic pyrophosphate; monosaccharide phosphate; pentose monosaccharide; imidazopyrimidine; purine; pyrimidone; aminopyrimidine; toluene; monosaccharide; organic phosphate; phosphoric acid ester; primary aromatic amine; pyrimidine; benzene; n-substituted imidazole; pyrazine; tetrahydrofuran; imidazole; oxolane; azole; secondary alcohol; 1,2-diol; polyol; ether; polyamine; alcohol; organonitrogen compound; primary amine; amine
Classification descriptionThis compound belongs to the flavin nucleotides. These are nucleotides containing a flavin moiety.
Pharmacology
IndicationUsed to treat eye diseases caused by vitamin B2 deficiency, such as keratitis and blepharitis.
PharmacodynamicsNot Available
Mechanism of actionNot Available
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Metabolism
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityOral mouse LD50 > 7000 mg/kg. Intravenous mouse LD50 589 mg/kg.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
Property Value Probability
Human Intestinal Absorption - 0.6156
Blood Brain Barrier + 0.5
Caco-2 permeable - 0.6995
P-glycoprotein substrate Substrate 0.6464
P-glycoprotein inhibitor I Non-inhibitor 0.7931
P-glycoprotein inhibitor II Non-inhibitor 0.9705
Renal organic cation transporter Non-inhibitor 0.9561
CYP450 2C9 substrate Non-substrate 0.8093
CYP450 2D6 substrate Non-substrate 0.8312
CYP450 3A4 substrate Substrate 0.5632
CYP450 1A2 substrate Non-inhibitor 0.8426
CYP450 2C9 substrate Non-inhibitor 0.8818
CYP450 2D6 substrate Non-inhibitor 0.8636
CYP450 2C19 substrate Non-inhibitor 0.872
CYP450 3A4 substrate Non-inhibitor 0.7323
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8967
Ames test Non AMES toxic 0.8242
Carcinogenicity Non-carcinogens 0.8105
Biodegradation Not ready biodegradable 0.9965
Rat acute toxicity 2.5009 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.9501
hERG inhibition (predictor II) Inhibitor 0.578
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
SolutionOphthalmic0.05%
PricesNot Available
PatentsNot Available
Properties
Statesolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
water solubility4.25e+00 g/lALOGPS
logP-0.78ALOGPS
logP-5.3ChemAxon
logS-2.3ALOGPS
pKa (strongest acidic)1.86ChemAxon
pKa (strongest basic)4.99ChemAxon
physiological charge-3ChemAxon
hydrogen acceptor count19ChemAxon
hydrogen donor count9ChemAxon
polar surface area356.42ChemAxon
rotatable bond count13ChemAxon
refractivity177.43ChemAxon
polarizability70.62ChemAxon
number of rings6ChemAxon
bioavailability0ChemAxon
rule of fiveNoChemAxon
Ghose filterNoChemAxon
Veber's ruleNoChemAxon
MDDR-like ruleYesChemAxon
Spectra
SpectraMS/MSLC-MS1D NMR2D NMR
References
Synthesis ReferenceNot Available
General ReferenceNot Available
External Links
ResourceLink
KEGG DrugD00005
KEGG CompoundC00016
PubChem Compound643975
PubChem Substance46508543
ChEBI16238
ChEMBLCHEMBL1232653
HETFAD
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSshow(692 KB)
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available

Targets

1. UDP-galactopyranose mutase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
UDP-galactopyranose mutase P37747 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

2. Flavohemoprotein

Kind: protein

Organism: Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

Pharmacological action: unknown

Components

Name UniProt ID Details
Flavohemoprotein P39662 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

3. Glycine oxidase

Kind: protein

Organism: Bacillus subtilis (strain 168)

Pharmacological action: unknown

Components

Name UniProt ID Details
Glycine oxidase O31616 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

4. NADPH--cytochrome P450 reductase

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
NADPH--cytochrome P450 reductase P16435 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

5. Glutaryl-CoA dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Glutaryl-CoA dehydrogenase, mitochondrial Q92947 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

6. Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial P11310 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

7. D-amino-acid oxidase

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
D-amino-acid oxidase P14920 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

8. Bifunctional protein PutA

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Bifunctional protein PutA P09546 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. Deoxyribodipyrimidine photo-lyase

Kind: protein

Organism: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Pharmacological action: unknown

Components

Name UniProt ID Details
Deoxyribodipyrimidine photo-lyase P61497 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

10. Amine oxidase [flavin-containing] A

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] A P21397 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

11. Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Short-chain specific acyl-CoA dehydrogenase, mitochondrial P16219 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

12. L-amino-acid oxidase

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
L-amino-acid oxidase Q96RQ9 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

13. 2,4-dienoyl-CoA reductase [NADPH]

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
2,4-dienoyl-CoA reductase [NADPH] P42593 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

14. 2-oxopropyl-CoM reductase, carboxylating

Kind: protein

Organism: Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)

Pharmacological action: unknown

Components

Name UniProt ID Details
2-oxopropyl-CoM reductase, carboxylating Q56839 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

15. p-hydroxybenzoate hydroxylase

Kind: protein

Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Pharmacological action: unknown

Components

Name UniProt ID Details
p-hydroxybenzoate hydroxylase P20586 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

16. Nitric oxide synthase, brain

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Nitric oxide synthase, brain P29475 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

17. NAD(P)H dehydrogenase [quinone] 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
NAD(P)H dehydrogenase [quinone] 1 P15559 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

18. p-hydroxybenzoate hydroxylase

Kind: protein

Organism: Pseudomonas fluorescens

Pharmacological action: unknown

Components

Name UniProt ID Details
p-hydroxybenzoate hydroxylase P00438 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

19. Fumarate reductase flavoprotein subunit

Kind: protein

Organism: Shewanella oneidensis (strain MR-1)

Pharmacological action: unknown

Components

Name UniProt ID Details
Fumarate reductase flavoprotein subunit P83223 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

20. ERO1-like protein beta

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
ERO1-like protein beta Q86YB8 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

21. Glutathione reductase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Glutathione reductase, mitochondrial P00390 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

22. NADPH-ferredoxin reductase FprA

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
NADPH-ferredoxin reductase FprA O05783 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

23. NADH-cytochrome b5 reductase 3

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
NADH-cytochrome b5 reductase 3 P00387 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

24. Cholesterol oxidase

Kind: protein

Organism: Streptomyces sp. (strain SA-COO)

Pharmacological action: unknown

Components

Name UniProt ID Details
Cholesterol oxidase P12676 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

25. Thymidylate synthase ThyX

Kind: protein

Organism: Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

Pharmacological action: unknown

Components

Name UniProt ID Details
Thymidylate synthase ThyX Q9WYT0 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

26. Pyruvate oxidase

Kind: protein

Organism: Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Pharmacological action: unknown

Components

Name UniProt ID Details
Pyruvate oxidase P37063 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

27. Thioredoxin reductase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Thioredoxin reductase P0A9P4 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

28. Glutathione reductase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Glutathione reductase P06715 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

29. 5,10-methylenetetrahydrofolate reductase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
5,10-methylenetetrahydrofolate reductase P0AEZ1 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

30. Monomeric sarcosine oxidase

Kind: protein

Organism: Bacillus sp. (strain B-0618)

Pharmacological action: unknown

Components

Name UniProt ID Details
Monomeric sarcosine oxidase P40859 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

31. Trypanothione reductase

Kind: protein

Organism: Trypanosoma cruzi

Pharmacological action: unknown

Components

Name UniProt ID Details
Trypanothione reductase P28593 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

32. Ribosyldihydronicotinamide dehydrogenase [quinone]

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

33. Isovaleryl-CoA dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Isovaleryl-CoA dehydrogenase, mitochondrial P26440 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

34. Xanthine dehydrogenase/oxidase

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Xanthine dehydrogenase/oxidase P47989 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

35. Cholesterol oxidase

Kind: protein

Organism: Brevibacterium sterolicum

Pharmacological action: unknown

Components

Name UniProt ID Details
Cholesterol oxidase P22637 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

36. N,N-dimethylglycine oxidase

Kind: protein

Organism: Arthrobacter globiformis

Pharmacological action: unknown

Components

Name UniProt ID Details
N,N-dimethylglycine oxidase Q9AGP8 Details

37. NADH peroxidase

Kind: protein

Organism: Enterococcus faecalis (strain ATCC 700802 / V583)

Pharmacological action: unknown

Components

Name UniProt ID Details
NADH peroxidase P37062 Details

38. Dihydropyrimidine dehydrogenase [NADP(+)]

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydropyrimidine dehydrogenase [NADP(+)] Q12882 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

39. Ferredoxin--NADP reductase

Kind: protein

Organism: Anabaena sp. (strain PCC 7119)

Pharmacological action: unknown

Components

Name UniProt ID Details
Ferredoxin--NADP reductase P21890 Details

40. D-lactate dehydrogenase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
D-lactate dehydrogenase P06149 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

41. Sulfite reductase [NADPH] flavoprotein alpha-component

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Sulfite reductase [NADPH] flavoprotein alpha-component P38038 Details

42. Thioredoxin reductase 1, cytoplasmic

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Thioredoxin reductase 1, cytoplasmic Q16881 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

43. Ferredoxin--NADP reductase

Kind: protein

Organism: Azotobacter vinelandii

Pharmacological action: unknown

Components

Name UniProt ID Details
Ferredoxin--NADP reductase Q44532 Details

44. Isobutyryl-CoA dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Isobutyryl-CoA dehydrogenase, mitochondrial Q9UKU7 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

45. Acyl-CoA dehydrogenase, short-chain specific

Kind: protein

Organism: Megasphaera elsdenii

Pharmacological action: unknown

Components

Name UniProt ID Details
Acyl-CoA dehydrogenase, short-chain specific Q06319 Details

46. Apoptosis-inducing factor 1, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Apoptosis-inducing factor 1, mitochondrial O95831 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

47. Ferredoxin reductase

Kind: protein

Organism: Pseudomonas sp. (strain KKS102)

Pharmacological action: unknown

Components

Name UniProt ID Details
Ferredoxin reductase Q52437 Details

48. Dihydrolipoyl dehydrogenase

Kind: protein

Organism: Azotobacter vinelandii

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydrolipoyl dehydrogenase P18925 Details

49. Amine oxidase, flavin-containing protein

Kind: protein

Organism: Pseudomonas syringae pv. tomato (strain DC3000)

Pharmacological action: unknown

Components

Name UniProt ID Details
Amine oxidase, flavin-containing protein Q888A4 Details

50. Deoxyribodipyrimidine photo-lyase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Deoxyribodipyrimidine photo-lyase P00914 Details

51. Deoxyribodipyrimidine photo-lyase

Kind: protein

Organism: Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)

Pharmacological action: unknown

Components

Name UniProt ID Details
Deoxyribodipyrimidine photo-lyase P05327 Details

52. L-aspartate oxidase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
L-aspartate oxidase P10902 Details

53. Cryptochrome DASH

Kind: protein

Organism: Synechocystis sp. (strain PCC 6803 / Kazusa)

Pharmacological action: unknown

Components

Name UniProt ID Details
Cryptochrome DASH P77967 Details

54. Dihydrolipoyl dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydrolipoyl dehydrogenase, mitochondrial P09622 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

55. Fumarate reductase flavoprotein subunit

Kind: protein

Organism: Shewanella frigidimarina (strain NCIMB 400)

Pharmacological action: unknown

Components

Name UniProt ID Details
Fumarate reductase flavoprotein subunit Q9Z4P0 Details

56. NADH-cytochrome b5 reductase 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
NADH-cytochrome b5 reductase 1 Q9UHQ9 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

57. Oxidoreductase

Kind: protein

Organism: Brevibacterium sterolicum

Pharmacological action: unknown

Components

Name UniProt ID Details
Oxidoreductase Q7SID9 Details

58. Amine oxidase [flavin-containing] B

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] B P27338 Details

59. NADPH:adrenodoxin oxidoreductase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
NADPH:adrenodoxin oxidoreductase, mitochondrial P22570 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

60. Peroxisomal acyl-coenzyme A oxidase 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Peroxisomal acyl-coenzyme A oxidase 1 Q15067 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

61. UDP-N-acetylenolpyruvoylglucosamine reductase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
UDP-N-acetylenolpyruvoylglucosamine reductase P08373 Details

62. FAD-linked sulfhydryl oxidase ALR

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
FAD-linked sulfhydryl oxidase ALR P55789 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

63. UDP-N-acetylenolpyruvoylglucosamine reductase

Kind: protein

Organism: Staphylococcus aureus (strain MW2)

Pharmacological action: unknown

Components

Name UniProt ID Details
UDP-N-acetylenolpyruvoylglucosamine reductase P61432 Details

64. Flavohemoprotein

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Flavohemoprotein P24232 Details

65. Phenol 2-hydroxylase component B

Kind: protein

Organism: Bacillus thermoglucosidasius

Pharmacological action: unknown

Components

Name UniProt ID Details
Phenol 2-hydroxylase component B Q9LAG2 Details

66. Methylenetetrahydrofolate reductase

Kind: protein

Organism: Thermus thermophilus

Pharmacological action: unknown

Components

Name UniProt ID Details
Methylenetetrahydrofolate reductase Q9RA47 Details

67. Putidaredoxin reductase

Kind: protein

Organism: Pseudomonas putida

Pharmacological action: unknown

Components

Name UniProt ID Details
Putidaredoxin reductase P16640 Details

68. NAD(P)H dehydrogenase (quinone)

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
NAD(P)H dehydrogenase (quinone) O53355 Details

69. UDP-galactopyranose mutase

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
UDP-galactopyranose mutase O06934 Details

70. 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase

Kind: protein

Organism: Clostridium aminobutyricum

Pharmacological action: unknown

Components

Name UniProt ID Details
4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase P55792 Details

71. 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit

Kind: protein

Organism: Pseudomonas putida

Pharmacological action: unknown

Components

Name UniProt ID Details
4-cresol dehydrogenase [hydroxylating] flavoprotein subunit P09788 Details

72. Alkyl hydroperoxide reductase subunit F

Kind: protein

Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

Pharmacological action: unknown

Components

Name UniProt ID Details
Alkyl hydroperoxide reductase subunit F P19480 Details

73. Outer membrane protein p64k or PM-6

Kind: protein

Organism: Neisseria meningitidis

Pharmacological action: unknown

Components

Name UniProt ID Details
Outer membrane protein p64k or PM-6 Q51225 Details

74. Glutathione reductase

Kind: protein

Organism: Plasmodium falciparum (isolate K1 / Thailand)

Pharmacological action: unknown

Components

Name UniProt ID Details
Glutathione reductase Q94655 Details

75. Phenylacetone monooxygenase

Kind: protein

Organism: Thermobifida fusca (strain YX)

Pharmacological action: unknown

Components

Name UniProt ID Details
Phenylacetone monooxygenase Q47PU3 Details

76. Benzoate 1,2-dioxygenase electron transfer component

Kind: protein

Organism: Acinetobacter sp. (strain ADP1)

Pharmacological action: unknown

Components

Name UniProt ID Details
Benzoate 1,2-dioxygenase electron transfer component P07771 Details

77. Putative acyl-CoA dehydrogenase

Kind: protein

Organism: Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)

Pharmacological action: unknown

Components

Name UniProt ID Details
Putative acyl-CoA dehydrogenase Q72JJ3 Details

78. FkbI

Kind: protein

Organism: Streptomyces hygroscopicus subsp. ascomyceticus

Pharmacological action: unknown

Components

Name UniProt ID Details
FkbI Q9KIE5 Details

79. Dihydrolipoyl dehydrogenase

Kind: protein

Organism: Pseudomonas putida

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydrolipoyl dehydrogenase P09063 Details

80. Dihydrolipoyl dehydrogenase

Kind: protein

Organism: Pseudomonas fluorescens

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydrolipoyl dehydrogenase P14218 Details

81. Alkyl hydroperoxide reductase subunit F

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Alkyl hydroperoxide reductase subunit F P35340 Details

82. Ferredoxin--NADP reductase

Kind: protein

Organism: Nostoc sp. (strain PCC 7120 / UTEX 2576)

Pharmacological action: unknown

Components

Name UniProt ID Details
Ferredoxin--NADP reductase P58558 Details

83. Ferredoxin--NADP reductase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Ferredoxin--NADP reductase P28861 Details

84. Mersacidin decarboxylase

Kind: protein

Organism: Bacillus sp. (strain HIL-Y85/54728)

Pharmacological action: unknown

Components

Name UniProt ID Details
Mersacidin decarboxylase Q9RC23 Details

85. Fumarate reductase flavoprotein subunit

Kind: protein

Organism: Shewanella frigidimarina

Pharmacological action: unknown

Components

Name UniProt ID Details
Fumarate reductase flavoprotein subunit P0C278 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Enzymes

1. Amine oxidase [flavin-containing] B

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] B P27338 Details
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Drug created on June 13, 2005 07:24 / Updated on September 30, 2013 11:27