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Identification
NameFlavin adenine dinucleotide
Accession NumberDB03147  (EXPT01391)
TypeSmall Molecule
GroupsApproved
Description

A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
Flavin adenine dinucleotide is approved for use in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency.

Structure
Thumb
Synonyms
SynonymLanguageCode
Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavineNot AvailableNot Available
Adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate]Not AvailableNot Available
FADNot AvailableNot Available
Flavin adenine dinucleotideNot AvailableNot Available
FLAVIN-adenine dinucleotideNot AvailableNot Available
Riboflavin 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosineNot AvailableNot Available
Riboflavin 5'-adenosine diphosphateNot AvailableNot Available
Prescription ProductsNot Available
Generic Prescription ProductsNot Available
Over the Counter ProductsNot Available
International Brands
NameCompany
AdeflavinNot Available
FlazirenNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Flavin adenine dinucleotide sodium
ThumbNot applicableDBSALT000903
CategoriesNot Available
CAS number146-14-5
WeightAverage: 785.5497
Monoisotopic: 785.157134455
Chemical FormulaC27H33N9O15P2
InChI KeyVWWQXMAJTJZDQX-UYBVJOGSSA-N
InChI
InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1
IUPAC Name
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy})phosphinic acid
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as flavin nucleotides. These are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassFlavin nucleotides
Sub ClassNot Available
Direct ParentFlavin nucleotides
Alternative Parents
Substituents
  • Flavin nucleotide
  • Purine ribonucleoside diphosphate
  • Flavin
  • Isoalloxazine
  • N-glycosyl compound
  • Glycosyl compound
  • Quinoxaline
  • Pteridine
  • Organic pyrophosphate
  • Monosaccharide phosphate
  • 6-aminopurine
  • Purine
  • Imidazopyrimidine
  • Monoalkyl phosphate
  • Pyrimidone
  • Aminopyrimidine
  • Imidolactam
  • Benzenoid
  • Alkyl phosphate
  • Pyrimidine
  • Pyrazine
  • Primary aromatic amine
  • Phosphoric acid ester
  • Organic phosphoric acid derivative
  • Organic phosphate
  • N-substituted imidazole
  • Monosaccharide
  • Saccharide
  • Heteroaromatic compound
  • Vinylogous amide
  • Oxolane
  • Imidazole
  • Azole
  • Secondary alcohol
  • Polyol
  • Lactam
  • 1,2-diol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationUsed to treat eye diseases caused by vitamin B2 deficiency, such as keratitis and blepharitis.
PharmacodynamicsNot Available
Mechanism of actionNot Available
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Metabolism
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityOral mouse LD50 > 7000 mg/kg. Intravenous mouse LD50 589 mg/kg.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
D-Arginine and D-Ornithine MetabolismMetabolicSMP00036
Capecitabine Metabolism PathwayDrug metabolismSMP00607
Capecitabine Action PathwayDrug actionSMP00469
Plasmalogen SynthesisMetabolicSMP00479
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty AcidsMetabolicSMP00480
Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (SCHAD)DiseaseSMP00568
Tamoxifen Metabolism PathwayDrug metabolismSMP00606
Glycerol Phosphate ShuttleMetabolicSMP00124
Vitamin K MetabolismMetabolicSMP00464
Tamoxifen Action PathwayDrug actionSMP00471
Familial lipoprotein lipase deficiencyDiseaseSMP00530
Doxorubicin Metabolism PathwayDrug metabolismSMP00650
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty AcidsMetabolicSMP00481
Glycerol Kinase DeficiencyDiseaseSMP00187
Citalopram Metabolism PathwayDrug metabolismSMP00627
2-aminoadipic 2-oxoadipic aciduriaDiseaseSMP00719
Lysine DegradationMetabolicSMP00037
Glycerolipid MetabolismMetabolicSMP00039
D-glyceric aciduraDiseaseSMP00529
Saccharopinuria/Hyperlysinemia IIDiseaseSMP00239
Hyperlysinemia II or SaccharopinuriaDiseaseSMP00528
Pyridoxine dependency with seizuresDiseaseSMP00571
Caffeine MetabolismMetabolicSMP00028
Pyruvaldehyde DegradationMetabolicSMP00459
Glutaric Aciduria Type IDiseaseSMP00186
Threonine and 2-Oxobutanoate DegradationMetabolicSMP00452
Hyperlysinemia I, FamilialDiseaseSMP00527
Nicotine Metabolism PathwayDrug metabolismSMP00628
Glutaric Aciduria Type IDiseaseSMP00185
Phenytoin (Antiarrhythmic) Action PathwayDrug actionSMP00327
HypophosphatasiaDiseaseSMP00503
Medium chain acyl-coa dehydrogenase deficiency (MCAD)DiseaseSMP00542
2-ketoglutarate dehydrogenase complex deficiencyDiseaseSMP00549
Butyrate MetabolismMetabolicSMP00073
Short Chain Acyl CoA Dehydrogenase Deficiency (SCAD Deficiency)DiseaseSMP00235
Mitochondrial Electron Transport ChainMetabolicSMP00355
Carnitine palmitoyl transferase deficiency (I)DiseaseSMP00538
Trifunctional protein deficiencyDiseaseSMP00545
Pyruvate dehydrogenase deficiency (E3)DiseaseSMP00550
Citric Acid CycleMetabolicSMP00057
Phospholipid BiosynthesisMetabolicSMP00025
Ethylmalonic EncephalopathyDiseaseSMP00181
Carnitine palmitoyl transferase deficiency (II)DiseaseSMP00541
Mitochondrial complex II deficiencyDiseaseSMP00548
Fatty acid MetabolismMetabolicSMP00051
Riboflavin MetabolismMetabolicSMP00070
Very-long-chain acyl coa dehydrogenase deficiency (VLCAD)DiseaseSMP00540
Fumarase deficiencyDiseaseSMP00547
Thyroid hormone synthesisMetabolicSMP00716
Vitamin B6 MetabolismMetabolicSMP00017
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty AcidsMetabolicSMP00482
Long chain acyl-CoA dehydrogenase deficiency (LCAD)DiseaseSMP00539
Congenital lactic acidosisDiseaseSMP00546
Pyruvate dehydrogenase deficiency (E2)DiseaseSMP00551
Valproic Acid Metabolism PathwayDrug metabolismSMP00635
Valine, Leucine and Isoleucine DegradationMetabolicSMP00032
3-Hydroxy-3-Methylglutaryl-CoA Lyase DeficiencyDiseaseSMP00138
Methylmalonate Semialdehyde Dehydrogenase DeficiencyDiseaseSMP00384
Lysosomal Acid Lipase Deficiency (Wolman Disease)DiseaseSMP00319
Ibandronate Action PathwayDrug actionSMP00079
Pravastatin Action PathwayDrug actionSMP00089
Bile Acid BiosynthesisMetabolicSMP00035
Congenital Erythropoietic Porphyria (CEP) or Gunther DiseaseDiseaseSMP00345
Zellweger SyndromeDiseaseSMP00316
Methylmalonic Aciduria Due to Cobalamin-Related DisordersDiseaseSMP00201
Risedronate Action PathwayDrug actionSMP00112
Mevalonic aciduriaDiseaseSMP00510
3-hydroxyisobutyric aciduriaDiseaseSMP00522
Maple Syrup Urine DiseaseDiseaseSMP00199
Methylmalonic AciduriaDiseaseSMP00200
Smith-Lemli-Opitz Syndrome (SLOS)DiseaseSMP00389
Gamma-Glutamyltransferase DeficiencyDiseaseSMP00183
Simvastatin Action PathwayDrug actionSMP00082
Rosuvastatin Action PathwayDrug actionSMP00092
Porphyrin MetabolismMetabolicSMP00024
Cerebrotendinous Xanthomatosis (CTX)DiseaseSMP00315
Hereditary Coproporphyria (HCP)DiseaseSMP00342
Pamidronate Action PathwayDrug actionSMP00117
Ureidopropionase deficiencyDiseaseSMP00492
Wolman diseaseDiseaseSMP00511
Isobutyryl-coa dehydrogenase deficiencyDiseaseSMP00523
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)DiseaseSMP00543
Betaine MetabolismMetabolicSMP00123
Folate MetabolismMetabolicSMP00053
Histidine MetabolismMetabolicSMP00044
Steroid BiosynthesisMetabolicSMP00023
Propionic AcidemiaDiseaseSMP00236
3-Methylglutaconic Aciduria Type IIIDiseaseSMP00140
5-OxoprolinuriaDiseaseSMP00143
Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)DiseaseSMP00388
HistidinemiaDiseaseSMP00191
Alendronate Action PathwayDrug actionSMP00095
Propanoate MetabolismMetabolicSMP00016
Nicotinate and Nicotinamide MetabolismMetabolicSMP00048
Porphyria Variegata (PV)DiseaseSMP00346
Familial Hypercholanemia (FHCA)DiseaseSMP00317
Malonic AciduriaDiseaseSMP00198
3-Methylglutaconic Aciduria Type IVDiseaseSMP00141
HypercholesterolemiaDiseaseSMP00209
Lovastatin Action PathwayDrug actionSMP00099
Cerivastatin Action PathwayDrug actionSMP00111
Nicotine Action PathwayDrug actionSMP00431
Malonyl-coa decarboxylase deficiencyDiseaseSMP00502
Hyper-IgD syndromeDiseaseSMP00509
3-hydroxyisobutyric acid dehydrogenase deficiencyDiseaseSMP00521
Isovaleric acidemiaDiseaseSMP00524
Glutathione MetabolismMetabolicSMP00015
Beta-Alanine MetabolismMetabolicSMP00007
2-Methyl-3-Hydroxybutryl CoA Dehydrogenase DeficiencyDiseaseSMP00137
3-Methylglutaconic Aciduria Type IDiseaseSMP00139
Glutathione Synthetase DeficiencyDiseaseSMP00337
DesmosterolosisDiseaseSMP00386
Acute Intermittent PorphyriaDiseaseSMP00344
Congenital Bile Acid Synthesis Defect Type IIIDiseaseSMP00318
Methotrexate Action PathwayDrug actionSMP00432
Zoledronate Action PathwayDrug actionSMP00107
Atorvastatin Action PathwayDrug actionSMP00131
Gamma-glutamyl-transpeptidase deficiencyDiseaseSMP00501
Cholesteryl ester storage diseaseDiseaseSMP00508
Mercaptopurine Metabolism PathwayDrug metabolismSMP00609
Folate malabsorption, hereditaryDiseaseSMP00724
Beta-Ketothiolase DeficiencyDiseaseSMP00173
3-Methylcrotonyl Coa Carboxylase Deficiency Type IDiseaseSMP00237
Isovaleric AciduriaDiseaseSMP00238
CHILD SyndromeDiseaseSMP00387
GABA-Transaminase DeficiencyDiseaseSMP00351
Congenital Bile Acid Synthesis Defect Type IIDiseaseSMP00314
Fluvastatin Action PathwayDrug actionSMP00119
Citalopram Action PathwayDrug actionSMP00424
Carnosinuria, carnosinemiaDiseaseSMP00493
5-oxoprolinase deficiencyDiseaseSMP00500
27-Hydroxylase DeficiencyDiseaseSMP00720
HypoacetylaspartiaDiseaseSMP00192
PhenylketonuriaDiseaseSMP00206
Tyrosinemia Type 3 (TYRO3)DiseaseSMP00370
Canavan DiseaseDiseaseSMP00175
Tyrosinemia Type 2 (or Richner-Hanhart syndrome)DiseaseSMP00369
Aspartate MetabolismMetabolicSMP00067
Leigh SyndromeDiseaseSMP00196
Ammonia RecyclingMetabolicSMP00009
Phenylalanine and Tyrosine MetabolismMetabolicSMP00008
Pyruvate MetabolismMetabolicSMP00060
Pyruvate Dehydrogenase Complex DeficiencyDiseaseSMP00212
Pyruvate kinase deficiencyDiseaseSMP00559
Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)DiseaseSMP00334
Primary hyperoxaluria II, PH2DiseaseSMP00558
Warburg EffectMetabolicSMP00654
Hyperprolinemia Type IDiseaseSMP00361
HypermethioninemiaDiseaseSMP00341
Tryptophan MetabolismMetabolicSMP00063
Tyrosinemia Type IDiseaseSMP00218
Beta Ureidopropionase DeficiencyDiseaseSMP00172
Creatine deficiency, guanidinoacetate methyltransferase deficiencyDiseaseSMP00504
Succinic semialdehyde dehydrogenase deficiencyDiseaseSMP00567
Methionine MetabolismMetabolicSMP00033
4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase DeficiencyDiseaseSMP00243
Prolinemia Type IIDiseaseSMP00208
S-Adenosylhomocysteine (SAH) Hydrolase DeficiencyDiseaseSMP00214
UMP Synthase Deiciency (Orotic Aciduria)DiseaseSMP00219
MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)DiseaseSMP00202
Dopamine beta-hydroxylase deficiencyDiseaseSMP00498
Hyperornithinemia with gyrate atrophy (HOGA)DiseaseSMP00505
HomocarnosinosisDiseaseSMP00385
Prolidase Deficiency (PD)DiseaseSMP00207
Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)DiseaseSMP00188
Glycine N-methyltransferase DeficiencyDiseaseSMP00222
Pyrimidine MetabolismMetabolicSMP00046
Dihydropyrimidinase DeficiencyDiseaseSMP00178
Tyrosinemia, transient, of the newbornDiseaseSMP00494
Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]DiseaseSMP00506
Hyperprolinemia Type IIDiseaseSMP00360
Cystathionine Beta-Synthase DeficiencyDiseaseSMP00177
Methionine Adenosyltransferase DeficiencyDiseaseSMP00221
HawkinsinuriaDiseaseSMP00190
Monoamine oxidase-a deficiency (MAO-A)DiseaseSMP00533
Glutamate MetabolismMetabolicSMP00072
Arginine and Proline MetabolismMetabolicSMP00020
Hyperinsulinism-Hyperammonemia SyndromeDiseaseSMP00339
Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)DiseaseSMP00362
Ornithine Aminotransferase Deficiency (OAT Deficiency)DiseaseSMP00363
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)DiseaseSMP00340
Tyrosine MetabolismMetabolicSMP00006
AlkaptonuriaDiseaseSMP00169
2-Hydroxyglutric Aciduria (D And L Form)DiseaseSMP00136
L-arginine:glycine amidinotransferase deficiencyDiseaseSMP00507
Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation typeDiseaseSMP00570
Molybdenum Cofactor DeficiencyDiseaseSMP00203
Purine Nucleoside Phosphorylase DeficiencyDiseaseSMP00210
SarcosinemiaDiseaseSMP00244
Hyperglycinemia, non-ketoticDiseaseSMP00485
Mitochondrial DNA depletion syndromeDiseaseSMP00536
Purine MetabolismMetabolicSMP00050
Adenylosuccinate Lyase DeficiencyDiseaseSMP00167
Non Ketotic HyperglycinemiaDiseaseSMP00223
Azathioprine Action PathwayDrug actionSMP00427
Adenosine Deaminase DeficiencyDiseaseSMP00144
AICA-RibosiduriaDiseaseSMP00168
Glycine and Serine MetabolismMetabolicSMP00004
Thioguanine Action PathwayDrug actionSMP00430
Disulfiram Action PathwayDrug actionSMP00429
Myoadenylate deaminase deficiencyDiseaseSMP00537
Gout or Kelley-Seegmiller SyndromeDiseaseSMP00365
Dimethylglycine Dehydrogenase DeficiencyDiseaseSMP00242
Mercaptopurine Action PathwayDrug actionSMP00428
Xanthinuria type IDiseaseSMP00512
Lesch-Nyhan Syndrome (LNS)DiseaseSMP00364
Xanthine Dehydrogenase Deficiency (Xanthinuria)DiseaseSMP00220
Dihydropyrimidine Dehydrogenase Deficiency (DHPD)DiseaseSMP00179
Dimethylglycine Dehydrogenase DeficiencyDiseaseSMP00484
Xanthinuria type IIDiseaseSMP00513
Adenine phosphoribosyltransferase deficiency (APRT)DiseaseSMP00535
3-Phosphoglycerate dehydrogenase deficiencyDiseaseSMP00721
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.6156
Blood Brain Barrier+0.5
Caco-2 permeable-0.6995
P-glycoprotein substrateSubstrate0.6464
P-glycoprotein inhibitor INon-inhibitor0.7931
P-glycoprotein inhibitor IINon-inhibitor0.9705
Renal organic cation transporterNon-inhibitor0.9561
CYP450 2C9 substrateNon-substrate0.8093
CYP450 2D6 substrateNon-substrate0.8312
CYP450 3A4 substrateSubstrate0.5632
CYP450 1A2 substrateNon-inhibitor0.8426
CYP450 2C9 substrateNon-inhibitor0.8818
CYP450 2D6 substrateNon-inhibitor0.8636
CYP450 2C19 substrateNon-inhibitor0.872
CYP450 3A4 substrateNon-inhibitor0.7323
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8967
Ames testNon AMES toxic0.8242
CarcinogenicityNon-carcinogens0.8105
BiodegradationNot ready biodegradable0.9965
Rat acute toxicity2.5009 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9501
hERG inhibition (predictor II)Inhibitor0.578
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility4.25 mg/mLALOGPS
logP-0.78ALOGPS
logP-5.3ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)1.86ChemAxon
pKa (Strongest Basic)4.99ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count19ChemAxon
Hydrogen Donor Count9ChemAxon
Polar Surface Area356.42 Å2ChemAxon
Rotatable Bond Count13ChemAxon
Refractivity177.43 m3·mol-1ChemAxon
Polarizability70.62 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraMS/MSLC-MS1D NMR2D NMR
References
Synthesis ReferenceNot Available
General ReferenceNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSDownload (692 KB)
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available

Targets

1. p-hydroxybenzoate hydroxylase

Kind: protein

Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Pharmacological action: unknown

Components

Name UniProt ID Details
p-hydroxybenzoate hydroxylase P20586 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

2. Nitric oxide synthase, brain

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Nitric oxide synthase, brain P29475 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

3. NAD(P)H dehydrogenase [quinone] 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
NAD(P)H dehydrogenase [quinone] 1 P15559 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

4. p-hydroxybenzoate hydroxylase

Kind: protein

Organism: Pseudomonas fluorescens

Pharmacological action: unknown

Components

Name UniProt ID Details
p-hydroxybenzoate hydroxylase P00438 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

5. Fumarate reductase flavoprotein subunit

Kind: protein

Organism: Shewanella oneidensis (strain MR-1)

Pharmacological action: unknown

Components

Name UniProt ID Details
Fumarate reductase flavoprotein subunit P83223 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

6. ERO1-like protein beta

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
ERO1-like protein beta Q86YB8 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

7. Glutathione reductase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Glutathione reductase, mitochondrial P00390 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

8. NADPH-ferredoxin reductase FprA

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
NADPH-ferredoxin reductase FprA O05783 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. NADH-cytochrome b5 reductase 3

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
NADH-cytochrome b5 reductase 3 P00387 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

10. Cholesterol oxidase

Kind: protein

Organism: Streptomyces sp. (strain SA-COO)

Pharmacological action: unknown

Components

Name UniProt ID Details
Cholesterol oxidase P12676 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

11. Thymidylate synthase ThyX

Kind: protein

Organism: Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

Pharmacological action: unknown

Components

Name UniProt ID Details
Thymidylate synthase ThyX Q9WYT0 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

12. Pyruvate oxidase

Kind: protein

Organism: Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Pharmacological action: unknown

Components

Name UniProt ID Details
Pyruvate oxidase P37063 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

13. Glutathione reductase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Glutathione reductase P06715 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

14. Monomeric sarcosine oxidase

Kind: protein

Organism: Bacillus sp. (strain B-0618)

Pharmacological action: unknown

Components

Name UniProt ID Details
Monomeric sarcosine oxidase P40859 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

15. Trypanothione reductase

Kind: protein

Organism: Trypanosoma cruzi

Pharmacological action: unknown

Components

Name UniProt ID Details
Trypanothione reductase P28593 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

16. Ribosyldihydronicotinamide dehydrogenase [quinone]

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

17. Isovaleryl-CoA dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Isovaleryl-CoA dehydrogenase, mitochondrial P26440 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

18. Xanthine dehydrogenase/oxidase

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Xanthine dehydrogenase/oxidase P47989 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

19. Cholesterol oxidase

Kind: protein

Organism: Brevibacterium sterolicum

Pharmacological action: unknown

Components

Name UniProt ID Details
Cholesterol oxidase P22637 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

20. Dihydropyrimidine dehydrogenase [NADP(+)]

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydropyrimidine dehydrogenase [NADP(+)] Q12882 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

21. D-lactate dehydrogenase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
D-lactate dehydrogenase P06149 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

22. Thioredoxin reductase 1, cytoplasmic

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Thioredoxin reductase 1, cytoplasmic Q16881 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

23. Isobutyryl-CoA dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Isobutyryl-CoA dehydrogenase, mitochondrial Q9UKU7 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

24. Apoptosis-inducing factor 1, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Apoptosis-inducing factor 1, mitochondrial O95831 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

25. UDP-galactopyranose mutase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
UDP-galactopyranose mutase P37747 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

26. Flavohemoprotein

Kind: protein

Organism: Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

Pharmacological action: unknown

Components

Name UniProt ID Details
Flavohemoprotein P39662 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

27. Glycine oxidase

Kind: protein

Organism: Bacillus subtilis (strain 168)

Pharmacological action: unknown

Components

Name UniProt ID Details
Glycine oxidase O31616 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

28. NADPH--cytochrome P450 reductase

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
NADPH--cytochrome P450 reductase P16435 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

29. Glutaryl-CoA dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Glutaryl-CoA dehydrogenase, mitochondrial Q92947 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

30. Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial P11310 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

31. D-amino-acid oxidase

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
D-amino-acid oxidase P14920 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

32. Bifunctional protein PutA

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Bifunctional protein PutA P09546 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

33. Deoxyribodipyrimidine photo-lyase

Kind: protein

Organism: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Pharmacological action: unknown

Components

Name UniProt ID Details
Deoxyribodipyrimidine photo-lyase P61497 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

34. Amine oxidase [flavin-containing] A

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] A P21397 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

35. Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Short-chain specific acyl-CoA dehydrogenase, mitochondrial P16219 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

36. L-amino-acid oxidase

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
L-amino-acid oxidase Q96RQ9 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

37. 2,4-dienoyl-CoA reductase [NADPH]

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
2,4-dienoyl-CoA reductase [NADPH] P42593 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

38. 2-oxopropyl-CoM reductase, carboxylating

Kind: protein

Organism: Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)

Pharmacological action: unknown

Components

Name UniProt ID Details
2-oxopropyl-CoM reductase, carboxylating Q56839 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

39. Fumarate reductase flavoprotein subunit

Kind: protein

Organism: Shewanella frigidimarina

Pharmacological action: unknown

Components

Name UniProt ID Details
Fumarate reductase flavoprotein subunit P0C278 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

40. Thioredoxin reductase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Thioredoxin reductase P0A9P4 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

41. 5,10-methylenetetrahydrofolate reductase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
5,10-methylenetetrahydrofolate reductase P0AEZ1 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

42. N,N-dimethylglycine oxidase

Kind: protein

Organism: Arthrobacter globiformis

Pharmacological action: unknown

Components

Name UniProt ID Details
N,N-dimethylglycine oxidase Q9AGP8 Details

43. NADH peroxidase

Kind: protein

Organism: Enterococcus faecalis (strain ATCC 700802 / V583)

Pharmacological action: unknown

Components

Name UniProt ID Details
NADH peroxidase P37062 Details

44. Ferredoxin--NADP reductase

Kind: protein

Organism: Anabaena sp. (strain PCC 7119)

Pharmacological action: unknown

Components

Name UniProt ID Details
Ferredoxin--NADP reductase P21890 Details

45. Sulfite reductase [NADPH] flavoprotein alpha-component

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Sulfite reductase [NADPH] flavoprotein alpha-component P38038 Details

46. Ferredoxin--NADP reductase

Kind: protein

Organism: Azotobacter vinelandii

Pharmacological action: unknown

Components

Name UniProt ID Details
Ferredoxin--NADP reductase Q44532 Details

47. Acyl-CoA dehydrogenase, short-chain specific

Kind: protein

Organism: Megasphaera elsdenii

Pharmacological action: unknown

Components

Name UniProt ID Details
Acyl-CoA dehydrogenase, short-chain specific Q06319 Details

48. Ferredoxin reductase

Kind: protein

Organism: Pseudomonas sp. (strain KKS102)

Pharmacological action: unknown

Components

Name UniProt ID Details
Ferredoxin reductase Q52437 Details

49. Dihydrolipoyl dehydrogenase

Kind: protein

Organism: Azotobacter vinelandii

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydrolipoyl dehydrogenase P18925 Details

50. Amine oxidase, flavin-containing protein

Kind: protein

Organism: Pseudomonas syringae pv. tomato (strain DC3000)

Pharmacological action: unknown

Components

Name UniProt ID Details
Amine oxidase, flavin-containing protein Q888A4 Details

51. Deoxyribodipyrimidine photo-lyase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Deoxyribodipyrimidine photo-lyase P00914 Details

52. Deoxyribodipyrimidine photo-lyase

Kind: protein

Organism: Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)

Pharmacological action: unknown

Components

Name UniProt ID Details
Deoxyribodipyrimidine photo-lyase P05327 Details

53. L-aspartate oxidase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
L-aspartate oxidase P10902 Details

54. Cryptochrome DASH

Kind: protein

Organism: Synechocystis sp. (strain PCC 6803 / Kazusa)

Pharmacological action: unknown

Components

Name UniProt ID Details
Cryptochrome DASH P77967 Details

55. Dihydrolipoyl dehydrogenase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydrolipoyl dehydrogenase, mitochondrial P09622 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

56. Fumarate reductase flavoprotein subunit

Kind: protein

Organism: Shewanella frigidimarina (strain NCIMB 400)

Pharmacological action: unknown

Components

Name UniProt ID Details
Fumarate reductase flavoprotein subunit Q9Z4P0 Details

57. NADH-cytochrome b5 reductase 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
NADH-cytochrome b5 reductase 1 Q9UHQ9 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

58. Oxidoreductase

Kind: protein

Organism: Brevibacterium sterolicum

Pharmacological action: unknown

Components

Name UniProt ID Details
Oxidoreductase Q7SID9 Details

59. Amine oxidase [flavin-containing] B

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] B P27338 Details

60. NADPH:adrenodoxin oxidoreductase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
NADPH:adrenodoxin oxidoreductase, mitochondrial P22570 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

61. Peroxisomal acyl-coenzyme A oxidase 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Peroxisomal acyl-coenzyme A oxidase 1 Q15067 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

62. UDP-N-acetylenolpyruvoylglucosamine reductase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
UDP-N-acetylenolpyruvoylglucosamine reductase P08373 Details

63. FAD-linked sulfhydryl oxidase ALR

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
FAD-linked sulfhydryl oxidase ALR P55789 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

64. UDP-N-acetylenolpyruvoylglucosamine reductase

Kind: protein

Organism: Staphylococcus aureus (strain MW2)

Pharmacological action: unknown

Components

Name UniProt ID Details
UDP-N-acetylenolpyruvoylglucosamine reductase P61432 Details

65. Flavohemoprotein

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Flavohemoprotein P24232 Details

66. Phenol 2-hydroxylase component B

Kind: protein

Organism: Bacillus thermoglucosidasius

Pharmacological action: unknown

Components

Name UniProt ID Details
Phenol 2-hydroxylase component B Q9LAG2 Details

67. Methylenetetrahydrofolate reductase

Kind: protein

Organism: Thermus thermophilus

Pharmacological action: unknown

Components

Name UniProt ID Details
Methylenetetrahydrofolate reductase Q9RA47 Details

68. Putidaredoxin reductase

Kind: protein

Organism: Pseudomonas putida

Pharmacological action: unknown

Components

Name UniProt ID Details
Putidaredoxin reductase P16640 Details

69. NAD(P)H dehydrogenase (quinone)

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
NAD(P)H dehydrogenase (quinone) O53355 Details

70. UDP-galactopyranose mutase

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
UDP-galactopyranose mutase O06934 Details

71. 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase

Kind: protein

Organism: Clostridium aminobutyricum

Pharmacological action: unknown

Components

Name UniProt ID Details
4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase P55792 Details

72. 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit

Kind: protein

Organism: Pseudomonas putida

Pharmacological action: unknown

Components

Name UniProt ID Details
4-cresol dehydrogenase [hydroxylating] flavoprotein subunit P09788 Details

73. Alkyl hydroperoxide reductase subunit F

Kind: protein

Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

Pharmacological action: unknown

Components

Name UniProt ID Details
Alkyl hydroperoxide reductase subunit F P19480 Details

74. Outer membrane protein p64k or PM-6

Kind: protein

Organism: Neisseria meningitidis

Pharmacological action: unknown

Components

Name UniProt ID Details
Outer membrane protein p64k or PM-6 Q51225 Details

75. Glutathione reductase

Kind: protein

Organism: Plasmodium falciparum (isolate K1 / Thailand)

Pharmacological action: unknown

Components

Name UniProt ID Details
Glutathione reductase Q94655 Details

76. Phenylacetone monooxygenase

Kind: protein

Organism: Thermobifida fusca (strain YX)

Pharmacological action: unknown

Components

Name UniProt ID Details
Phenylacetone monooxygenase Q47PU3 Details

77. Benzoate 1,2-dioxygenase electron transfer component

Kind: protein

Organism: Acinetobacter sp. (strain ADP1)

Pharmacological action: unknown

Components

Name UniProt ID Details
Benzoate 1,2-dioxygenase electron transfer component P07771 Details

78. Putative acyl-CoA dehydrogenase

Kind: protein

Organism: Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)

Pharmacological action: unknown

Components

Name UniProt ID Details
Putative acyl-CoA dehydrogenase Q72JJ3 Details

79. FkbI

Kind: protein

Organism: Streptomyces hygroscopicus subsp. ascomyceticus

Pharmacological action: unknown

Components

Name UniProt ID Details
FkbI Q9KIE5 Details

80. Dihydrolipoyl dehydrogenase

Kind: protein

Organism: Pseudomonas putida

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydrolipoyl dehydrogenase P09063 Details

81. Dihydrolipoyl dehydrogenase

Kind: protein

Organism: Pseudomonas fluorescens

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydrolipoyl dehydrogenase P14218 Details

82. Alkyl hydroperoxide reductase subunit F

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Alkyl hydroperoxide reductase subunit F P35340 Details

83. Ferredoxin--NADP reductase

Kind: protein

Organism: Nostoc sp. (strain PCC 7120 / UTEX 2576)

Pharmacological action: unknown

Components

Name UniProt ID Details
Ferredoxin--NADP reductase P58558 Details

84. Ferredoxin--NADP reductase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Ferredoxin--NADP reductase P28861 Details

85. Mersacidin decarboxylase

Kind: protein

Organism: Bacillus sp. (strain HIL-Y85/54728)

Pharmacological action: unknown

Components

Name UniProt ID Details
Mersacidin decarboxylase Q9RC23 Details

Enzymes

1. Amine oxidase [flavin-containing] B

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] B P27338 Details
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Drug created on June 13, 2005 07:24 / Updated on September 30, 2013 11:27