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Displaying drugs 151 - 175 of 8072 in total

Gadoxetic acid

Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. Gadoxetate is a...
Approved
Matched Description: … contrast of enhancement and therefore heightening the liver parenchyma-liver tumours contrast. ... anion-transporting polypeptides (OATPs) and liver tumor cells lack OATPs, liver tumors show a lack of …
Matched Categories: … Diagnostic Uses of Chemicals …

Tedizolid phosphate

Drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus penumoniae, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved linezolid and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the...
Approved
Matched Description: … [A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the ... Tedizolid is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Milnacipran

Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the additional indication of...
Approved
Investigational
Matched Description: … robust evidence of efficacy, insufficient demonstration of maintenance of effect, and other concerns ... category was originally developed for and continues to be approved and indicated for the treatment of ... somewhat increased preference for noradrenaline reuptake inhibition - which is potentially a point of …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sumatriptan

Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. Sumatriptan was granted FDA approval on 28 December 1992.
Approved
Investigational
Matched Description: … [L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available …
Matched Categories: … combinations of sulfonamides ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Benzocaine

Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.
Approved
Investigational
Matched Description: … Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve …
Matched Categories: … Esters of Aminobenzoic Acid ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Sulfadoxine

A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.
Approved
Investigational
Matched Categories: … combinations of sulfonamides …

Estriol

A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is...
Approved
Investigational
Vet approved
Matched Description: … Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement ... During pregnancy, large amount of estriol is produced by the placenta. ... Isomers with inversion of the hydroxyl group or groups are called epiestriol. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Mafenide

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder...
Approved
Vet approved
Withdrawn
Matched Description: … It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep ... In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA …
Matched Categories: … combinations of sulfonamides …

Isatuximab

Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic antibody targeted against CD38, a glycoprotein found on the...
Approved
Investigational
Matched Description: … [L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains ... [L12099] It is a cytolytic antibody targeted against CD38, a glycoprotein found on the surface of some ... ] isatuximab was granted Orphan Drug designation and approved on March 2nd, 2020, for the treatment of …
Matched Categories: … CD38 (Clusters of Differentiation 38) inhibitors …

Cloxacillin

A semi-synthetic penicillin antibiotic which is a chlorinated derivative of oxacillin.
Approved
Investigational
Vet approved
Matched Description: … A semi-synthetic penicillin antibiotic which is a chlorinated derivative of [oxacillin]. …
Matched Categories: … combinations of penicillins …

Iopromide

Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can cause several serious adverse effects, including...
Approved
Matched Description: … It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, ... permitting radiographic visualization of the internal structures until significant hemodilution occurs ... intrathecally inadvertently, it is still deemed to have a favorable safety profile, with only 0.7% of …
Matched Categories: … Diagnostic Uses of Chemicals …

Pramocaine

Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications...
Approved
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Clonidine

Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.
Approved
Matched Description: … Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. ... [A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD. …

Mephentermine

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra...
Approved
Matched Description: … Although the central stimulant effects of mephentermine are much less than those of amphetamine, its …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sulfamerazine

A sulfanilamide that is used as an antibacterial agent.
Approved
Vet approved
Matched Categories: … combinations of sulfonamides …

Gepirone

Gepirone, an azapirone, is a pharmacologic analog of buspirone that acts selectively on the pre- and post-synaptic 5HT1A receptors. Although earlier clinical trials showed promising results for gepirone, its formulation as an immediate-release tablet necessitates frequent administration due to the short half-lives. It was not until an extended-release formulation of...
Approved
Investigational
Matched Description: … side effects as that of the placebo. ... Gepirone, an azapirone, is a pharmacologic analog of [buspirone] that acts selectively on the pre- and ... It was not until an extended-release formulation of gepirone was made available that gepirone became …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Menotropins

Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women. It is used as a fertility medication that is injected either subcutaneously or intramuscularly. It is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with...
Approved
Matched Description: … Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of ... It is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Liothyronine

Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed...
Approved
Vet approved
Matched Description: … Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine …
Matched Salts cas: … 55-06-1 …
Matched Categories: … combinations of levothyroxine and liothyronine …

Polysorbate 80

Polysorbate, a substance formulated by the reaction of sorbitan fatty acid ester (a nonionic surfactant) with ethylene oxide, is used in many foreign countries, including the U.S. and the EU, where it acts as an emulsifier, a solubilizer in many foods, including bread, cake mix, salad dressing, shortening oil and...
Approved
Matched Description: … Polysorbate, a substance formulated by the reaction of sorbitan fatty acid ester (a nonionic surfactant ... substance that would not normally dissolve in a particular solution is able to dissolve with the use of ... [L1852] A solubilizing agent acts as a surfactant and increases the solubility of one agent in another …
Matched Mixtures name: … Refresh Digital PF …

Bamlanivimab

Bamlanivimab (LY-CoV555, also known as LY3819253), is a synthetic monoclonal antibody (mAb) derived from one of the first blood samples in the United States from a patient who recovered from COVID-19.[A224039, L15311, L15316] Bamlanivimab is a neutralizing IgG1κ mAb directed against the SARS-CoV-2 spike (S) protein, which is described to...
Approved
Investigational
Matched Description: … [A224039, L15311, L15316] Bamlanivimab is a neutralizing IgG1κ mAb directed against the SARS-CoV-2 spike ... Bamlanivimab consists of two identical light chains of 214 amino acids and two identical heavy chains ... of 455 amino acids each; the Fc region is unmodified. …

Codeine

The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease...
Approved
Illicit
Matched Description: … The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for ... increasing the ability of patients to engage in day to day activities. …
Matched Mixtures name: … Acetaminophen, Caffeine, and 8mg Of Codeine Phosphate Tablets ... Acetaminophen, Caffeine and 8 Mg Of Codeine Phosphate Tablets …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Obinutuzumab

Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV)...
Approved
Investigational
Matched Description: … There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal …
Matched Categories: … CD20 (Clusters of Differentiation 20) inhibitors …

Ioxilan

Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs.
Approved
Matched Description: … Intravascular injection results in opacification of vessels in the path of flow of the contrast medium ... , permitting radiographic visualization of the internal structures of the human body until significant …
Matched Categories: … Diagnostic Uses of Chemicals …

Nitroglycerin

Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief...
Approved
Investigational
Matched Description: … [A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Gliclazide

Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It has been classified differently according to its drug properties in which based on its chemical structure, gliclazide is considered a first-generation sulfonylurea due to the structural presence of a sulfonamide group able to release...
Approved
Matched Description: … Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination ... the last 8-10 weeks of glucose control). ... β cells of the pancreas to release insulin. …
Matched Categories: … combinations of sulfonamides …
Displaying drugs 151 - 175 of 8072 in total