Cardiotoxic antineoplastic agents

Antineoplastic drugs known to have a major cardiotoxic effect
DrugDrug NameDrug Indication
DB00997DoxorubicinDoxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.
DB00531CyclophosphamideCyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.
DB01008BusulfanFor use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia (FDA has designated busulfan as an orphan drug for this use). It is also used as a component of pretransplant conditioning regimens in patients undergoing bone marrow transplantation for acute myeloid leukemia and nonmalignant diseases.
DB06171Paclitaxel trevatideInvestigated for use/treatment in brain cancer.
DB13809Paclitaxel poliglumexNot Available
DB00112BevacizumabAs part of combination therapy for metastatic colorectal cancer and HER2-negative metastatic breast cancer.
DB00619ImatinibFor the treatment of Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML), Ph+ acute lymphoblastic leukaemia, myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis, hypereosinophilic syndrome and/or chronic eosinophilic leukemia (CEL), dermatofibrosarcoma protuberans, and malignant gastrointestinal stromal tumors (GIST).
DB00445EpirubicinFor use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
DB06013AldoxorubicinInvestigated for use/treatment in solid tumors.
DB00694DaunorubicinFor remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.
DB01204MitoxantroneFor the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis
DB00515CisplatinFor the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
DB01181IfosfamideUsed as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma.
DB00305MitomycinFor treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery.
DB01101CapecitabineFor the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated.
DB00544FluorouracilFor the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
DB00987CytarabineFor the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
DB01073FludarabineFor the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
DB00563MethotrexateMethotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents. Methotrexate is also indicated in the treatment of meningeal leukemia. Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell types. Methotrexate is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkin’s lymphomas. Methotrexate is indicated in the symptomatic control of severe, recalcitrant, disabling psoriasis. Methotrexate is indicated in the management of selected adults with severe, active rheumatoid arthritis (ACR criteria), or children with active polyarticular-course juvenile rheumatoid arthritis.
DB01229PaclitaxelUsed in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.
DB00541VincristineTreatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
DB00570VinblastineFor treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
DB01217AnastrozoleFor adjuvant treatment of hormone receptor positive breast cancer , as well as hormonal treatment of advanced breast cancer in post-menopausal women. Has also been used to treat pubertal gynecomastia and McCune-Albright syndrome; however, manufacturer states that efficacy for these indications have not been established.
DB00008Peginterferon alfa-2aPeginterferon alfa-2a is indicated for the treatment of HCV in combination with other antiviral drugs in patients over 5 years of age with compensated liver disease [FDA Label]. May be used as a monotherapy in patients with contraindications to or significant intolerance to other anti-viral therapies. Peginterferon alfa-2a is also indicated as a monotherapy for adult patients with HBeAg positive and HBeAg negative chronic hepatitis B infection who have compensated liver disease and evidence of viral replication and liver inflammation [FDA Label].
DB01041ThalidomideFor the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). Also for use as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence.
DB00290BleomycinFor palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
DB00552PentostatinFor the treatment of hairy cell leukaemia refractory to alpha interferon.
DB01169Arsenic trioxideFor induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression
DB00675TamoxifenTamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.
DB00188BortezomibFor treatment of multiple myeloma in patients who have not been successfully treated with at least two previous therapies.
DB01248DocetaxelFor the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. It is also used in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer. Furthermore, docetaxel has uses in the treatment of gastric adenocarinoma and head and neck cancer.
DB01177IdarubicinFor the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.
DB00262CarmustineFor the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
DB00888MechlorethamineFor the palliative treatment of Hodgkin's disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma. Also for the palliative treatment of metastatic carcinoma resulting in effusion.
DB00773EtoposideFor use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.
DB00444TeniposideTeniposide is used for the treatment of refractory acute lymphoblastic leukaemia
DB00276AmsacrineFor treatment of acute myeloid leukaemia.
DB00242CladribineFor the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
DB00755TretinoinFor the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
DB00309VindesineFor the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis
DB00361Vinorelbine Vinorelbine tartrate is indicated for adults in the treatment of advanced non-small cell lung cancer (NSCLC), as a single therapy or in combination with other chemotherapeutic drugs [L1998]. Used in relapsed or refractory Hodgkin lymphoma, in combination with other chemotherapy agents [L2011]. For the treatment of desmoid tumor or aggressive fibromatosis, in combination with methotrexate [L2011]. For the treatment of recurrent or metastatic squamous cell head and neck cancer [L2011]. For the treatment of recurrent ovarian cancer [L2011]. For the treatment of metastatic breast cancer, in patients previously treated with anthracyline and/or taxane therapy [L2011]. For the treatment of HER2-positive, trastuzumab-resistant, advanced breast cancer in patients previously treated with a taxane, in combination with trastuzumab and everolimus [L2011].
DB00072TrastuzumabFor treatment of early stage HER2-positive breast cancer, or metastatic breast cancer that substantially overexpress HER2.
DB06772CabazitaxelFor treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
DrugDrug NameTargetType
DB00997DoxorubicinSerum albumincarrier
DB00997DoxorubicinCytochrome P450 3A4enzyme
DB00997DoxorubicinCytochrome P450 2D6enzyme
DB00997DoxorubicinCytochrome P450 2B6enzyme
DB00997DoxorubicinCytochrome P450 1B1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DB00997DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DB00997DoxorubicinAldo-keto reductase family 1 member C3enzyme
DB00997DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00997DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DB00997DoxorubicinNitric oxide synthase, endothelialenzyme
DB00997DoxorubicinNitric oxide synthase, inducibleenzyme
DB00997DoxorubicinNitric oxide synthase, brainenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DB00997DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DB00997DoxorubicinDNA topoisomerase 2-alphatarget
DB00997DoxorubicinDNAtarget
DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1target
DB00997DoxorubicinMultidrug resistance protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DB00997DoxorubicinMultidrug resistance-associated protein 6transporter
DB00997DoxorubicinMultidrug resistance-associated protein 1transporter
DB00997DoxorubicinMultidrug resistance-associated protein 7transporter
DB00997DoxorubicinATP-binding cassette sub-family G member 2transporter
DB00997DoxorubicinBile salt export pumptransporter
DB00997DoxorubicinSolute carrier family 22 member 16transporter
DB00997DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DB00997DoxorubicinRalA-binding protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideDNAtarget
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB01008BusulfanCytochrome P450 3A4enzyme
DB01008BusulfanGlutathione S-transferase A2enzyme
DB01008BusulfanGlutathione S-transferase A1enzyme
DB01008BusulfanGlutathione S-transferase Mu 1enzyme
DB01008BusulfanGlutathione S-transferase Penzyme
DB01008BusulfanMicrosomal glutathione S-transferase 2enzyme
DB01008BusulfanDNAtarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00112BevacizumabComplement C1r subcomponenttarget
DB00112BevacizumabComplement C1q subcomponent subunit Atarget
DB00112BevacizumabComplement C1q subcomponent subunit Btarget
DB00112BevacizumabComplement C1q subcomponent subunit Ctarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00112BevacizumabHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor II-ctarget
DB00112BevacizumabVascular endothelial growth factor Atarget
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibProstaglandin G/H synthase 1enzyme
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibRET proto-oncogenetarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibBCR/ABL fusion protein isoform X9target
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibMultidrug resistance protein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibBile salt export pumptransporter
DB00445EpirubicinUDP-glucuronosyltransferase 2B7enzyme
DB00445EpirubicinCytosolic phospholipase A2enzyme
DB00445EpirubicinChromodomain-helicase-DNA-binding protein 1target
DB00445EpirubicinDNA topoisomerase 2-alphatarget
DB00445EpirubicinDNAtarget
DB00445EpirubicinMultidrug resistance-associated protein 1transporter
DB06013AldoxorubicinDNA topoisomerase 2-alphatarget
DB00694DaunorubicinXanthine dehydrogenase/oxidaseenzyme
DB00694DaunorubicinCytochrome P450 3A5enzyme
DB00694DaunorubicinNADPH--cytochrome P450 reductaseenzyme
DB00694DaunorubicinCytochrome P450 1A1enzyme
DB00694DaunorubicinCytochrome P450 1B1enzyme
DB00694DaunorubicinCytochrome P450 3A4enzyme
DB00694DaunorubicinDNAtarget
DB00694DaunorubicinDNA topoisomerase 2-alphatarget
DB00694DaunorubicinDNA topoisomerase 2-betatarget
DB00694DaunorubicinMultidrug resistance protein 1transporter
DB00694DaunorubicinMultidrug resistance-associated protein 1transporter
DB00694DaunorubicinCanalicular multispecific organic anion transporter 1transporter
DB00694DaunorubicinMultidrug resistance-associated protein 6transporter
DB00694DaunorubicinBile salt export pumptransporter
DB00694DaunorubicinMultidrug resistance-associated protein 7transporter
DB00694DaunorubicinATP-binding cassette sub-family G member 2transporter
DB01204MitoxantroneCytochrome P450 2E1enzyme
DB01204MitoxantroneCytochrome P450 1B1enzyme
DB01204MitoxantroneCytochrome P450 3A4enzyme
DB01204MitoxantroneDNA topoisomerase 2-alphatarget
DB01204MitoxantroneDNAtarget
DB01204MitoxantroneMultidrug resistance protein 1transporter
DB01204MitoxantroneMultidrug resistance-associated protein 1transporter
DB01204MitoxantroneATP-binding cassette sub-family G member 2transporter
DB00515CisplatinSerum albumincarrier
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNAtarget
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinMultidrug resistance protein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB01181IfosfamideCytochrome P450 2B6enzyme
DB01181IfosfamideCytochrome P450 3A4enzyme
DB01181IfosfamideCytochrome P450 3A5enzyme
DB01181IfosfamideCytochrome P450 2C9enzyme
DB01181IfosfamideCytochrome P450 2C8enzyme
DB01181IfosfamideCytochrome P450 2A6enzyme
DB01181IfosfamideCytochrome P450 2C19enzyme
DB01181IfosfamideCytochrome P450 2C18enzyme
DB01181IfosfamideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideDNAtarget
DB01181IfosfamideNuclear receptor subfamily 1 group I member 2target
DB00305MitomycinNADPH--cytochrome P450 reductaseenzyme
DB00305MitomycinDNAtarget
DB01101CapecitabineThymidine phosphorylaseenzyme
DB01101CapecitabineCytidine deaminaseenzyme
DB01101CapecitabineLiver carboxylesterase 1enzyme
DB01101CapecitabineDihydropyrimidine dehydrogenase [NADP(+)]enzyme
DB01101CapecitabineCytochrome P450 2C9enzyme
DB01101CapecitabineThymidylate synthasetarget
DB01101CapecitabineDNAtarget
DB01101CapecitabineRNAtarget
DB00544FluorouracilSerum albumincarrier
DB00544FluorouracilCytochrome P450 1A2enzyme
DB00544FluorouracilThymidine phosphorylaseenzyme
DB00544FluorouracilCytochrome P450 2C9enzyme
DB00544FluorouracilDihydropyrimidine dehydrogenase [NADP(+)]enzyme
DB00544FluorouracilUridine phosphorylase 1enzyme
DB00544FluorouracilUridine phosphorylase 2enzyme
DB00544FluorouracilCytochrome P450 2A6enzyme
DB00544FluorouracilCytochrome P450 2C8enzyme
DB00544FluorouracilMethylenetetrahydrofolate reductaseenzyme
DB00544FluorouracilThymidylate synthaseenzyme
DB00544FluorouracilUridine 5'-monophosphate synthaseenzyme
DB00544FluorouracilAmidophosphoribosyltransferaseenzyme
DB00544FluorouracilThymidylate synthasetarget
DB00544FluorouracilDNAtarget
DB00544FluorouracilRNAtarget
DB00544FluorouracilSolute carrier family 22 member 7transporter
DB00544FluorouracilEquilibrative nucleoside transporter 1transporter
DB00544FluorouracilATP-binding cassette sub-family G member 2transporter
DB00544FluorouracilCanalicular multispecific organic anion transporter 2transporter
DB00544FluorouracilMultidrug resistance-associated protein 4transporter
DB00544FluorouracilMultidrug resistance-associated protein 5transporter
DB00987CytarabineCytidine deaminaseenzyme
DB00987CytarabineCytochrome P450 3A4enzyme
DB00987CytarabineDeoxycytidine kinaseenzyme
DB00987Cytarabine5'-nucleotidaseenzyme
DB00987CytarabineDeoxycytidylate deaminaseenzyme
DB00987CytarabineDNA polymerase betatarget
DB00987CytarabineDNAtarget
DB00987CytarabineSolute carrier family 22 member 1transporter
DB00987CytarabineMultidrug resistance-associated protein 7transporter
DB00987CytarabineEquilibrative nucleoside transporter 1transporter
DB01073FludarabineDNA polymerase alpha catalytic subunittarget
DB01073FludarabineRibonucleoside-diphosphate reductase large subunittarget
DB01073FludarabineDNAtarget
DB01073FludarabineDeoxycytidine kinasetarget
DB01073FludarabineEquilibrative nucleoside transporter 1transporter
DB01073FludarabineSolute carrier family 28 member 3transporter
DB00563MethotrexateSerum albumincarrier
DB00563MethotrexateAldehyde oxidaseenzyme
DB00563MethotrexateMethylenetetrahydrofolate reductaseenzyme
DB00563Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00563MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
DB00563MethotrexateGamma-glutamyl hydrolaseenzyme
DB00563MethotrexateDihydrofolate reductaseenzyme
DB00563MethotrexateThymidylate synthaseenzyme
DB00563MethotrexateBifunctional purine biosynthesis protein PURHenzyme
DB00563MethotrexateCytochrome P450 3A4enzyme
DB00563MethotrexateDihydrofolate reductasetarget
DB00563MethotrexateCanalicular multispecific organic anion transporter 2transporter
DB00563MethotrexateMultidrug resistance-associated protein 4transporter
DB00563MethotrexateMultidrug resistance-associated protein 1transporter
DB00563MethotrexateSolute carrier family 22 member 6transporter
DB00563MethotrexateMultidrug resistance-associated protein 7transporter
DB00563MethotrexateSolute carrier family 22 member 8transporter
DB00563MethotrexateCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateMultidrug resistance protein 1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1A2transporter
DB00563MethotrexateMonocarboxylate transporter 1transporter
DB00563MethotrexateATP-binding cassette sub-family C member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B3transporter
DB00563MethotrexateSolute carrier family 22 member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1C1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 3A1transporter
DB00563MethotrexateATP-binding cassette sub-family G member 2transporter
DB00563MethotrexateSolute carrier family 22 member 7transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B1transporter
DB00563MethotrexateProton-coupled folate transportertransporter
DB00563MethotrexateSolute carrier organic anion transporter family member 4C1transporter
DB00563MethotrexateFolate transporter 1transporter
DB00563MethotrexateFolate receptor alphatransporter
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelMultidrug resistance protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelATP-binding cassette sub-family G member 2transporter
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineCytochrome P450 3A4enzyme
DB00541VincristineCytochrome P450 3A5enzyme
DB00541VincristineCytochrome P450 3A7enzyme
DB00541VincristineTubulin beta chaintarget
DB00541VincristineTubulin alpha-4A chaintarget
DB00541VincristineMultidrug resistance protein 1transporter
DB00541VincristineCanalicular multispecific organic anion transporter 2transporter
DB00541VincristineSolute carrier family 22 member 3transporter
DB00541VincristineMultidrug resistance-associated protein 1transporter
DB00541VincristineMultidrug resistance-associated protein 7transporter
DB00541VincristineCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineBile salt export pumptransporter
DB00541VincristineATP-binding cassette sub-family G member 2transporter
DB00541VincristineRalA-binding protein 1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B3transporter
DB00570VinblastineCytochrome P450 3A4enzyme
DB00570VinblastineCytochrome P450 2D6enzyme
DB00570VinblastineTubulin beta chaintarget
DB00570VinblastineTranscription factor AP-1target
DB00570VinblastineTubulin alpha-1A chaintarget
DB00570VinblastineTubulin delta chaintarget
DB00570VinblastineTubulin epsilon chaintarget
DB00570VinblastineTubulin gamma-1 chaintarget
DB00570VinblastineMultidrug resistance protein 1transporter
DB00570VinblastineMultidrug resistance-associated protein 1transporter
DB00570VinblastineCanalicular multispecific organic anion transporter 1transporter
DB00570VinblastineMultidrug resistance-associated protein 6transporter
DB00570VinblastineBile salt export pumptransporter
DB00570VinblastineSolute carrier organic anion transporter family member 1B1transporter
DB01217AnastrozoleCytochrome P450 19A1enzyme
DB01217AnastrozoleCytochrome P450 1A2enzyme
DB01217AnastrozoleCytochrome P450 2C9enzyme
DB01217AnastrozoleCytochrome P450 3A4enzyme
DB01217AnastrozoleCytochrome P450 19A1target
DB00008Peginterferon alfa-2aCytochrome P450 1A2enzyme
DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 2target
DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 1target
DB01041ThalidomideCytochrome P450 2C19enzyme
DB01041ThalidomideCytochrome P450 1A1enzyme
DB01041ThalidomideCytochrome P450 2E1enzyme
DB01041ThalidomideCytochrome P450 2C9enzyme
DB01041ThalidomideProstaglandin G/H synthase 1enzyme
DB01041ThalidomideProstaglandin G/H synthase 2enzyme
DB01041ThalidomideCytochrome P450 3A5enzyme
DB01041ThalidomideTumor necrosis factortarget
DB01041ThalidomideNuclear factor NF-kappa-B p105 subunittarget
DB01041ThalidomideProstaglandin G/H synthase 2target
DB01041ThalidomideFibroblast growth factor receptor 2target
DB01041ThalidomideDNAtarget
DB01041ThalidomideProtein cereblontarget
DB01041ThalidomideNuclear factor kappa-light-chain-enhancer of activated B cellstarget
DB01041Thalidomidealpha1-acid glycoproteintarget
DB00290BleomycinBleomycin hydrolaseenzyme
DB00290BleomycinDNA ligase 3target
DB00290BleomycinDNA ligase 1target
DB00290BleomycinDNAtarget
DB00552PentostatinAdenosine deaminasetarget
DB01169Arsenic trioxideSerum albumincarrier
DB01169Arsenic trioxideCytochrome P450 1A1enzyme
DB01169Arsenic trioxideCytochrome P450 1B1enzyme
DB01169Arsenic trioxideCytochrome P450 3A4enzyme
DB01169Arsenic trioxideInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB01169Arsenic trioxideTranscription factor AP-1target
DB01169Arsenic trioxideG1/S-specific cyclin-D1target
DB01169Arsenic trioxideMitogen-activated protein kinase 3target
DB01169Arsenic trioxideMitogen-activated protein kinase 1target
DB01169Arsenic trioxideRAC-alpha serine/threonine-protein kinasetarget
DB01169Arsenic trioxideThioredoxin reductase 1, cytoplasmictarget
DB01169Arsenic trioxideCyclin-dependent kinase inhibitor 1target
DB01169Arsenic trioxideHistone deacetylase 1target
DB01169Arsenic trioxideProtein PMLtarget
DB01169Arsenic trioxideCanalicular multispecific organic anion transporter 1transporter
DB01169Arsenic trioxideMultidrug resistance protein 1transporter
DB00675TamoxifenCytochrome P450 2C9enzyme
DB00675TamoxifenCytochrome P450 3A4enzyme
DB00675TamoxifenCytochrome P450 2D6enzyme
DB00675TamoxifenCytochrome P450 2C8enzyme
DB00675TamoxifenCytochrome P450 2B6enzyme
DB00675TamoxifenLiver carboxylesterase 1enzyme
DB00675TamoxifenCytochrome P450 3A5enzyme
DB00675TamoxifenCytochrome P450 1A1enzyme
DB00675TamoxifenCytochrome P450 1B1enzyme
DB00675TamoxifenCytochrome P450 2C19enzyme
DB00675TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00675TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00675TamoxifenCytochrome P450 3A7enzyme
DB00675TamoxifenCytochrome P450 19A1enzyme
DB00675TamoxifenCytochrome P450 2A6enzyme
DB00675TamoxifenCytochrome P450 2E1enzyme
DB00675TamoxifenUDP-glucuronosyltransferase 1-10enzyme
DB00675TamoxifenSulfotransferase 1A1enzyme
DB00675TamoxifenEstrogen receptor alphatarget
DB00675TamoxifenEstrogen receptor betatarget
DB00675Tamoxifen3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget
DB00675TamoxifenProtein kinase Ctarget
DB00675TamoxifenAndrogen receptortarget
DB00675TamoxifenPotassium voltage-gated channel subfamily H member 2target
DB00675TamoxifenNuclear receptor subfamily 1 group I member 2target
DB00675TamoxifenEstrogen-related receptor gammatarget
DB00675TamoxifenSex hormone-binding globulintarget
DB00675TamoxifenMultidrug resistance protein 1transporter
DB00675TamoxifenATP-binding cassette sub-family G member 2transporter
DB00675TamoxifenCanalicular multispecific organic anion transporter 1transporter
DB00675TamoxifenBile salt export pumptransporter
DB00188BortezomibCytochrome P450 3A4enzyme
DB00188BortezomibCytochrome P450 2C19enzyme
DB00188BortezomibCytochrome P450 1A2enzyme
DB00188BortezomibCytochrome P450 2D6enzyme
DB00188BortezomibCytochrome P450 2C9enzyme
DB00188BortezomibProteasome subunit beta type-5target
DB00188BortezomibProteasome subunit beta type-1target
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB01248DocetaxelMultidrug resistance protein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01177IdarubicinCytochrome P450 2C9enzyme
DB01177IdarubicinCytochrome P450 2D6enzyme
DB01177IdarubicinDNA topoisomerase 2-alphatarget
DB01177IdarubicinDNAtarget
DB01177IdarubicinMultidrug resistance-associated protein 1transporter
DB00262CarmustineCytochrome P450 1A2enzyme
DB00262CarmustineGlutathione reductase, mitochondrialtarget
DB00262CarmustineDNAtarget
DB00262CarmustineRNAtarget
DB00888MechlorethamineDNAtarget
DB00773EtoposideCytochrome P450 3A4enzyme
DB00773EtoposideCytochrome P450 1A2enzyme
DB00773EtoposideCytochrome P450 2C8enzyme
DB00773EtoposideCytochrome P450 2E1enzyme
DB00773EtoposideCytochrome P450 3A5enzyme
DB00773EtoposideUDP-glucuronosyltransferase 1-1enzyme
DB00773EtoposideGlutathione S-transferase theta-1enzyme
DB00773EtoposideGlutathione S-transferase Penzyme
DB00773EtoposideProstaglandin G/H synthase 2enzyme
DB00773EtoposideProstaglandin G/H synthase 1enzyme
DB00773EtoposideDNA topoisomerase 2-alphatarget
DB00773EtoposideDNA topoisomerase 2-betatarget
DB00773EtoposideCanalicular multispecific organic anion transporter 2transporter
DB00773EtoposideMultidrug resistance-associated protein 6transporter
DB00773EtoposideMultidrug resistance protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 7transporter
DB00773EtoposideCanalicular multispecific organic anion transporter 1transporter
DB00773EtoposideATP-binding cassette sub-family G member 2transporter
DB00444TeniposideCytochrome P450 2C19enzyme
DB00444TeniposideCytochrome P450 2C9enzyme
DB00444TeniposideCytochrome P450 3A4enzyme
DB00444TeniposideCytochrome P450 3A5enzyme
DB00444TeniposideDNA topoisomerase 2-alphatarget
DB00444TeniposideMultidrug resistance-associated protein 6transporter
DB00444TeniposideATP-binding cassette sub-family G member 2transporter
DB00276AmsacrineDNA topoisomerase 2-alphatarget
DB00276AmsacrineDNAtarget
DB00276AmsacrinePotassium voltage-gated channel subfamily H member 2target
DB00276AmsacrineAlpha-1-acid glycoprotein 1target
DB00276AmsacrineSerum albumintarget
DB00276AmsacrineMultidrug resistance protein 1transporter
DB00242CladribineDeoxycytidine kinaseenzyme
DB00242CladribinePurine nucleoside phosphorylasetarget
DB00242CladribineDNAtarget
DB00242CladribineRibonucleoside-diphosphate reductase large subunittarget
DB00242CladribineRibonucleoside-diphosphate reductase subunit M2target
DB00242CladribineRibonucleoside-diphosphate reductase subunit M2 Btarget
DB00242CladribineDNA polymerase alpha catalytic subunittarget
DB00242CladribineDNA polymerase epsilon catalytic subunit Atarget
DB00242CladribineDNA polymerase epsilon subunit 2target
DB00242CladribineDNA polymerase epsilon subunit 3target
DB00242CladribineDNA polymerase epsilon subunit 4target
DB00242CladribineATP-binding cassette sub-family G member 2transporter
DB00242CladribineSolute carrier family 28 member 3transporter
DB00755TretinoinSerum albumincarrier
DB00755TretinoinCytochrome P450 2C8enzyme
DB00755TretinoinCytochrome P450 2B6enzyme
DB00755TretinoinCytochrome P450 3A4enzyme
DB00755TretinoinCytochrome P450 3A5enzyme
DB00755TretinoinCytochrome P450 2A6enzyme
DB00755TretinoinCytochrome P450 3A7enzyme
DB00755TretinoinCytochrome P450 2C18enzyme
DB00755TretinoinCytochrome P450 2C9enzyme
DB00755TretinoinCytochrome P450 4A11enzyme
DB00755TretinoinCytochrome P450 1A1enzyme
DB00755TretinoinRetinoic acid receptor gammatarget
DB00755TretinoinRetinoic acid receptor RXR-betatarget
DB00755TretinoinRetinal dehydrogenase 1target
DB00755TretinoinRetinoic acid-induced protein 3target
DB00755TretinoinRetinoic acid receptor RXR-gammatarget
DB00755TretinoinNuclear receptor subfamily 0 group B member 1target
DB00755TretinoinRetinal dehydrogenase 2target
DB00755TretinoinRetinoic acid receptor responder protein 1target
DB00755TretinoinRetinoic acid receptor alphatarget
DB00755TretinoinRetinoic acid receptor betatarget
DB00755TretinoinLipocalin-1target
DB00755TretinoinOdorant-binding protein 2atarget
DB00755TretinoinRetinol-binding protein 4target
DB00755Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
DB00755TretinoinRetinoic acid receptor RXR-alphatarget
DB00755TretinoinCytochrome P450 26A1target
DB00755TretinoinCytochrome P450 26B1target
DB00755TretinoinCytochrome P450 26C1target
DB00755TretinoinHematopoietic prostaglandin D synthasetarget
DB00755TretinoinCellular retinoic acid-binding protein 1transporter
DB00755TretinoinCellular retinoic acid-binding protein 2transporter
DB00309VindesineCytochrome P450 3A4enzyme
DB00309VindesineTubulin beta-1 chaintarget
DB00361VinorelbineCytochrome P450 3A4enzyme
DB00361VinorelbineCytochrome P450 2D6enzyme
DB00361VinorelbineTubulin beta chaintarget
DB00361VinorelbineMultidrug resistance protein 1transporter
DB00072TrastuzumabCytochrome P450 19A1enzyme
DB00072TrastuzumabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00072TrastuzumabComplement C1r subcomponenttarget
DB00072TrastuzumabComplement C1q subcomponent subunit Atarget
DB00072TrastuzumabComplement C1q subcomponent subunit Btarget
DB00072TrastuzumabComplement C1q subcomponent subunit Ctarget
DB00072TrastuzumabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00072TrastuzumabComplement C1s subcomponenttarget
DB00072TrastuzumabHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00072TrastuzumabLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB00072TrastuzumabLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB00072TrastuzumabLow affinity immunoglobulin gamma Fc region receptor II-ctarget
DB00072TrastuzumabReceptor tyrosine-protein kinase erbB-2target
DB00072TrastuzumabEpidermal growth factor receptortarget
DB06772CabazitaxelCytochrome P450 3A4enzyme
DB06772CabazitaxelCytochrome P450 3A5enzyme
DB06772CabazitaxelCytochrome P450 2C8enzyme
DB06772CabazitaxelTubulin alpha-4A chaintarget
DB06772CabazitaxelTubulin beta-1 chaintarget
DB06772CabazitaxelMultidrug resistance protein 1transporter
DB06772CabazitaxelATP-binding cassette sub-family G member 2transporter
DB06772CabazitaxelSolute carrier organic anion transporter family member 1B1transporter
DB06772CabazitaxelSolute carrier organic anion transporter family member 1B3transporter