Diabetic Macular Edema (DME)

Also known as: Diabetic Macular Edema / Macular Edema, Diabetic / Diabetic Macular Oedema / Diabetic retinal oedema / Diabetic retinal edema

DrugDrug NameDrug Description
DB08885AfliberceptAflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It contains approximately 15% glycosylation to give a total molecular weight of 115 kDa. All five putative N-glycosylation sites on each polypeptide chain predicted by the primary sequence can be occupied with carbohydrate and exhibit some degree of chain heterogeneity, including heterogeneity in terminal sialic acid residues, except at the single unsialylated site associated with the Fc domain. Aflibercept, as an ophthalmic agent, is used in the treatment of macular edema following Central Retinal Vein Occlusion (CRVO) and neovascular Age-Related Macular Degeneration (AMD). Ziv-aflibercept, under the brand name Zaltrap, was developed as an injection for treatment of metastatic colorectal cancer. FDA approved in November 18, 2011 and EMA approved in November 2012.
DB01234DexamethasoneAn anti-inflammatory 9-fluoro-glucocorticoid.
DB00591Fluocinolone acetonideFluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity.[T357] It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices.[T358] This type of device containing fluocinolone acetonide was developed by Taro Pharmaceuticals and approved by FDA in May 2016.[L4676]
DB01270RanibizumabRanibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab has a molecular weight of approximately 48 kilodaltons and is produced by an E. coli expression system in a nutrient medium containing the antibiotic tetracycline (tetracycline is not detectable in the final product). Ranibizumab is marketed under the name Lucentis®. It is indicated for the treatment of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.
DrugDrug NameTargetType
DB08885AfliberceptVascular endothelial growth factor Atarget
DB08885AfliberceptPlacenta growth factortarget
DB08885AfliberceptVascular endothelial growth factor Btarget
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneP-glycoprotein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB01234DexamethasoneCytochrome P450 11B1, mitochondrialenzyme
DB00591Fluocinolone acetonideCorticosteroid-binding globulincarrier
DB00591Fluocinolone acetonideGlucocorticoid receptortarget
DB00591Fluocinolone acetonideCytochrome P450 3A4enzyme
DB00591Fluocinolone acetonideAnnexin A1target
DB00591Fluocinolone acetonideAnnexin A2target
DB00591Fluocinolone acetonideAnnexin A3target
DB00591Fluocinolone acetonideAnnexin A4target
DB00591Fluocinolone acetonideAnnexin A5target
DB01270RanibizumabVascular endothelial growth factor Atarget
DrugDrug NamePhaseStatusCount
DB08885Aflibercept1Completed1
DB08885Aflibercept1Recruiting1
DB00963Bromfenac1Unknown Status1
DB00095Efalizumab1Withdrawn1
DB11611Lifitegrast1Terminated1
DB15330Nesvacumab1Completed1
DB01270Ranibizumab1Completed1
DB01270Ranibizumab1Withdrawn2
DB00877Sirolimus1Completed1
DB06343Teprotumumab1Completed1
DB00620Triamcinolone1Completed2
DB00620Triamcinolone1Unknown Status1
DB08885Aflibercept1 / 2Completed2
DB08885Aflibercept1 / 2Recruiting1
DB00112Bevacizumab1 / 2Completed1
DB01200Bromocriptine1 / 2Withdrawn1
DB01234Dexamethasone1 / 2Active Not Recruiting1
DB01234Dexamethasone1 / 2Completed1
DB00514Dextromethorphan1 / 2Completed1
DB11981Elamipretide1 / 2Completed1
DB00065Infliximab1 / 2Unknown Status1
DB00264Metoprolol1 / 2Withdrawn1
DB01017Minocycline1 / 2Completed1
DB01270Ranibizumab1 / 2Active Not Recruiting1
DB01270Ranibizumab1 / 2Completed5
DB01270Ranibizumab1 / 2Recruiting1
DB01270Ranibizumab1 / 2Unknown Status1
DB14911Risuteganib1 / 2Withdrawn1
DB00706Tamsulosin1 / 2Withdrawn1
DB00620Triamcinolone1 / 2Completed1
DB00620Triamcinolone1 / 2Unknown Status1
DB08885Aflibercept2Completed4
DB08885Aflibercept2Not Yet Recruiting2
DB09026Aliskiren2Terminated1
DB00112Bevacizumab2Completed5
DB00112Bevacizumab2Unknown Status1
DB06642Bevasiranib2Completed1
DB01406Danazol2Completed1
DB01234Dexamethasone2Completed6
DB01234Dexamethasone2Not Yet Recruiting1
DB01234Dexamethasone2Unknown Status1
DB00988Dopamine2Recruiting1
DB00869Dorzolamide2Completed1
DB15303Faricimab2Completed1
DB13873Fenofibric acid2Completed1
DB00591Fluocinolone acetonide2Completed1
DB00741Hydrocortisone2Completed1
DB04465Lactose2Recruiting1
DB00678Losartan2Completed1
DB00657Mecamylamine2Completed1
DB06802Nepafenac2Completed1
DB15330Nesvacumab2Completed1
DB05028Ocriplasmin2Completed1
DB08888Ocriplasmin2Completed1
DB14955PF-046348172Terminated1
DB04895Pegaptanib2Completed1
DB01270Ranibizumab2Completed14
DB01270Ranibizumab2Recruiting2
DB01270Ranibizumab2Terminated1
DB01270Ranibizumab2Unknown Status3
DB01270Ranibizumab2Withdrawn2
DB14911Risuteganib2Completed1
DB00877Sirolimus2Completed1
DB00373Timolol2Completed1
DB06273Tocilizumab2Withdrawn1
DB00620Triamcinolone2Completed6
DB05268iCo-0072Unknown Status1
DB08885Aflibercept2 / 3Active Not Recruiting1
DB08885Aflibercept2 / 3Completed1
DB08885Aflibercept2 / 3Recruiting1
DB00443Betamethasone2 / 3Completed1
DB00112Bevacizumab2 / 3Completed1
DB00112Bevacizumab2 / 3Not Yet Recruiting1
DB00112Bevacizumab2 / 3Recruiting2
DB01234Dexamethasone2 / 3Unknown Status1
DB00591Fluocinolone acetonide2 / 3Completed1
DB00591Fluocinolone acetonide2 / 3Withdrawn1
DB01270Ranibizumab2 / 3Recruiting1
DB01270Ranibizumab2 / 3Unknown Status1
DB01270Ranibizumab2 / 3Withdrawn1
DB00620Triamcinolone2 / 3Completed4
DB08885Aflibercept3Active Not Recruiting2
DB08885Aflibercept3Completed2
DB08885Aflibercept3Not Yet Recruiting2
DB08885Aflibercept3Recruiting6
DB00112Bevacizumab3Active Not Recruiting1
DB00112Bevacizumab3Completed5
DB00112Bevacizumab3Recruiting1
DB00112Bevacizumab3Unknown Status4
DB14864Brolucizumab3Not Yet Recruiting2
DB14864Brolucizumab3Recruiting2
DB12460Conbercept3Recruiting1
DB01406Danazol3Completed1
DB01234Dexamethasone3Completed3
DB15303Faricimab3Recruiting2
DB08162Fasudil3Completed1
DB00591Fluocinolone acetonide3Completed3
DB00065Infliximab3Terminated1
DB06802Nepafenac3Completed1
DB04895Pegaptanib3Completed1
DB15212Pemafibrate3Terminated1
DB01270Ranibizumab3Active Not Recruiting1
DB01270Ranibizumab3Completed11
DB01270Ranibizumab3Recruiting1
DB11829Ruboxistaurin3Completed1
DB00620Triamcinolone3Completed7
DB00620Triamcinolone3Unknown Status3
DB08885Aflibercept4Active Not Recruiting2
DB08885Aflibercept4Completed8
DB08885Aflibercept4Not Yet Recruiting3
DB08885Aflibercept4Recruiting6
DB08885Aflibercept4Withdrawn1
DB00126Ascorbic acid4Completed1
DB00112Bevacizumab4Completed7
DB00112Bevacizumab4Enrolling by Invitation1
DB00112Bevacizumab4Recruiting1
DB00112Bevacizumab4Unknown Status1
DB00963Bromfenac4Completed1
DB06724Calcium carbonate4Completed1
DB11059Carboxymethylcellulose4Enrolling by Invitation1
DB00169Cholecalciferol4Completed1
DB00115Cyanocobalamin4Completed1
DB01234Dexamethasone4Completed5
DB01234Dexamethasone4Not Yet Recruiting2
DB01234Dexamethasone4Recruiting3
DB01234Dexamethasone4Terminated1
DB00586Diclofenac4Recruiting1
DB00591Fluocinolone acetonide4Active Not Recruiting1
DB00591Fluocinolone acetonide4Completed1
DB00591Fluocinolone acetonide4Withdrawn1
DB00158Folic acid4Completed1
DB01592Iron4Completed1
DB06802Nepafenac4Completed1
DB06802Nepafenac4Enrolling by Invitation1
DB02701Nicotinamide4Completed1
DB04895Pegaptanib4Completed2
DB04895Pegaptanib4Recruiting1
DB06715Potassium Iodide4Completed1
DB00165Pyridoxine4Completed1
DB01270Ranibizumab4Active Not Recruiting2
DB01270Ranibizumab4Completed4
DB01270Ranibizumab4Enrolling by Invitation1
DB01270Ranibizumab4Not Yet Recruiting1
DB01270Ranibizumab4Recruiting4
DB01270Ranibizumab4Terminated1
DB01270Ranibizumab4Withdrawn1
DB00140Riboflavin4Completed1
DB00152Thiamine4Completed1
DB00620Triamcinolone4Completed2
DB00163Vitamin E4Completed1
DB09321Zinc oxide4Completed1
DB08885AfliberceptNot AvailableActive Not Recruiting1
DB08885AfliberceptNot AvailableCompleted7
DB08885AfliberceptNot AvailableRecruiting3
DB00009AlteplaseNot AvailableTerminated1
DB00126Ascorbic acidNot AvailableUnknown Status1
DB00112BevacizumabNot AvailableCompleted5
DB00112BevacizumabNot AvailableNot Yet Recruiting1
DB00112BevacizumabNot AvailableTerminated1
DB01234DexamethasoneNot AvailableCompleted6
DB01234DexamethasoneNot AvailableNot Yet Recruiting1
DB01234DexamethasoneNot AvailableTerminated1
DB00869DorzolamideNot AvailableRecruiting1
DB00591Fluocinolone acetonideNot AvailableRecruiting1
DB11735GalactoseNot AvailableTerminated1
DB04077GlycerinNot AvailableCompleted1
DB04335InosineNot AvailableUnknown Status1
DB00465KetorolacNot AvailableCompleted1
DB00151L-CysteineNot AvailableUnknown Status1
DB00281LidocaineNot AvailableCompleted1
DB14596Loteprednol etabonateNot AvailableCompleted1
DB00563MethotrexateNot AvailableTerminated1
DB01017MinocyclineNot AvailableUnknown Status1
DB02701NicotinamideNot AvailableUnknown Status1
DB04895PegaptanibNot AvailableAvailable1
DB04895PegaptanibNot AvailableCompleted1
DB06812Povidone-iodineNot AvailableUnknown Status1
DB00807ProparacaineNot AvailableCompleted2
DB01270RanibizumabNot AvailableActive Not Recruiting1
DB01270RanibizumabNot AvailableCompleted8
DB09085TetracaineNot AvailableCompleted1
DB11251TocopherolNot AvailableUnknown Status1
DB12647TocotrienolNot AvailableUnknown Status1
DB00620TriamcinoloneNot AvailableCompleted2
DB09270UbidecarenoneNot AvailableUnknown Status1