Premature Births

Also known as: PreTerm Birth / Premature Birth / Birth premature / Premature birth, NOS / Early onset of delivery / Premature delivery / Premature baby / Baby premature / Immature baby / 28 completed weeks or more but less than 37 completed weeks (196 completed days but less than 259 completed days) of gestation. / Prematurity / Infant premature

DrugDrug NameDrug Description
DB06761BeractantBeractant is a pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants. Considered a natural source of surfactant as it is made from bovine lung extract, beractant contains a mixture of phospholipids, neutral lipids, fatty acids, and surfactant-associated proteins such as SP-B and SP-C. The final composition provides 25 mg/mL phospholipids (including 11.0-15.5 mg/mL disaturated phosphatidylcholine), 0.5-1.75 mg/mL triglycerides, 1.4-3.5 mg/mL free fatty acids, and less than 1.0 mg/mL protein. It is suspended in 0.9% sodium chloride solution, and heat-sterilized. In anticipation of birth, endogenous lung surfactant is produced to lower the surface tension on alveolar surfaces and to stabilize the alveoli against collapse at resting transpulmonary pressures. However, in Respiratory Distress Syndrome, developmental deficiency of surfactant results collapse of the alveoli causing fast breathing, increased heart rate, apoxia, and sometimes death. Administration of lung surfactant remains the cornerstone of therapy in this condition that is currently the leading cause of death in preterm infants. In comparison to synthetic forms of surfacant, natural forms such as Beractant have been found to have a reduced incidence of pneumothorax and reduced mortality.
DB06789Hydroxyprogesterone caproateHydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid). Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. Food and Drug Administration (FDA) in 1956 and withdrawn from marketing in 1999. The U.S. FDA approved Makena from KV Pharmaceutical (previously named as Gestiva) on February 4, 2011 for prevention of preterm delivery in women with a history of preterm delivery, sparking a pricing controversy.
DrugDrug NamePhaseStatusCount
DB00653Magnesium sulfate0Completed1
DB00945Acetylsalicylic acid2Completed1
DB11121Chloroxylenol2Completed1
DB00741Hydrocortisone2Completed1
DB00328Indomethacin2Unknown Status1
DB04897Lucinactant2Terminated1
DB01065Melatonin2Completed1
DB00929Misoprostol2Completed1
DB00471Montelukast2Completed1
DB00396Progesterone2Recruiting1
DB01234Dexamethasone2 / 3Recruiting1
DB00378Dydrogesterone2 / 3Not Yet Recruiting1
DB06789Hydroxyprogesterone caproate2 / 3Recruiting1
DB01065Melatonin2 / 3Terminated1
DB00110Palivizumab2 / 3Completed1
DB00396Progesterone2 / 3Not Yet Recruiting1
DB00396Progesterone2 / 3Recruiting1
DB00396Progesterone2 / 3Withdrawn1
DB00443Betamethasone3Withdrawn1
DB11121Chloroxylenol3Completed1
DB06789Hydroxyprogesterone caproate3Active Not Recruiting1
DB01378Magnesium3Recruiting1
DB11110Magnesium citrate3Recruiting1
DB00388Phenylephrine3Terminated1
DB01708Prasterone3Recruiting1
DB00396Progesterone3Completed4
DB00396Progesterone3Not Yet Recruiting1
DB00396Progesterone3Unknown Status1
DB09153Sodium Chloride3Unknown Status1
DB00945Acetylsalicylic acid4Completed1
DB06755Beta carotene4Completed1
DB00112Bevacizumab4Recruiting1
DB00169Cholecalciferol4Completed1
DB01190Clindamycin4Completed1
DB01234Dexamethasone4Completed1
DB03756Doconexent4Active Not Recruiting1
DB09341Glucose4Completed1
DB06789Hydroxyprogesterone caproate4Recruiting1
DB01378Magnesium4Completed1
DB01115Nifedipine4Completed2
DB00435Nitric Oxide4Completed1
DB00396Progesterone4Recruiting1
DB01270Ranibizumab4Recruiting1
DB00867Ritodrine4Completed1
DB00162Vitamin A4Completed1
DB01593Zinc4Completed1
DB11175Zinc picolinate4Completed1
DB00945Acetylsalicylic acidNot AvailableRecruiting1
DB00653Magnesium sulfateNot AvailableTerminated1
DB01115NifedipineNot AvailableTerminated1
DB00396ProgesteroneNot AvailableCompleted3
DB00396ProgesteroneNot AvailableNot Yet Recruiting1
DB00396ProgesteroneNot AvailableRecruiting1
DB00396ProgesteroneNot AvailableTerminated1
DB00396ProgesteroneNot AvailableWithdrawn2