Blood Glucose Lowering Agents

Name
Blood Glucose Lowering Agents
Accession Number
DBCAT002698  (DBCAT000137, DBCAT002199)
Description

Substances which lower blood glucose levels.

ATC Classification
Drugs
DrugDrug Description
Insulin humanA recombinant form of human insulin used to control hyperglycemia in diabetes mellitus.
Insulin lisproA modified form of fast-acting insulin used to control hyperglycemia in diabetes mellitus.
Insulin glargineA modified form of long-acting or basal insulin used to control hyperglycemia in diabetes mellitus.
GlimepirideA sulfonylurea drug used to treat type 2 diabetes mellitus.
DisopyramideA class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias.
AcarboseAn alpha-glucosidase inhibitor used in conjunction with diet and exercise for management of type II diabetes mellitus.
MetforminA biguanide drug used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus and used off-label for insulin resistance in polycystic ovary syndrome (PCOS).
SulfadiazineA sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid.
RosiglitazoneA thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes.
QuinineAn alkaloid used to treat uncomplicated Plasmodium falciparum malaria.
MiglitolAn oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates.
ChlorpropamideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
NateglinideA meglitinide used to treat non insulin dependent diabetes mellitus.
PentamidineAn antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV.
MifepristoneA cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation.
TolazamideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
RepaglinideA antihyperglycemic used to improve glycemic control in diabetes.
SulfamethoxazoleAn oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract.
GlyburideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
GlipizideA sulfonylurea medication used in Type 2 Diabetes to sensitize pancreatic beta cells and stimulate insulin release.
GliclazideA sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
TolbutamideA sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
PioglitazoneA thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus.
BromocriptineA dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome.
SitagliptinAn oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus.
SunitinibA receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).
ExenatideA GLP-1 agonist used in the management of type 2 diabetes mellitus.
MecaserminA recombinant insulin-like growth factor-1 used for the long-term treatment of growth failure in pediatric patients with primary IGF-1 deficiency or with growth hormone gene deletion due to the development of neutralizing antibodies to GH.
PramlintideAn amylin analog used for the management of type 1 and type 2 diabetes mellitus as an adjunct to preprandial insulin therapy in patients without adequate glycemic control of insulin therapy.
Insulin aspartA rapid-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus.
Insulin detemirA long-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus.
Insulin glulisineA short-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus.
AlogliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus.
DapagliflozinA sodium-glucose cotransporter 2 inhibitor used in the management of type 2 diabetes mellitus.
SaxagliptinAn DPP-4 inhibitor used for the management of type 2 diabetes mellitus.
LiraglutideA GLP-1 analog used in the management of type 2 diabetes mellitus and prevention of cardiovascular complications associated with diabetes.
CanagliflozinA sodium-glucose co-transporter 2 (SGLT2) inhibitor used to manage hyperglycemia in type 2 diabetes mellitus (DM). Also used to reduce the risk of major cardiovascular events in patients with established cardiovascular disease and type 2 DM.
EmpagliflozinAn SGLT2 inhibitor used to manage type 2 diabetes mellitus.
AlbiglutideA GLP-1 agonist used to manage type 2 diabetes mellitus.
DulaglutideA GLP-1 agonist used to manage type 2 diabetes mellitus.
PhenforminFor the reatment of type II diabetes mellitus.
MitiglinideFor the treatment of type 2 diabetes.
GlymidineGlycodiazine is used concomitantly with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.
BuforminBuformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of...
VogliboseFor the treatment of diabetes. It is specifically used for lowering post-prandial blood glucose levels thereby reducing the risk of macrovascular complications.
BenfluorexBenfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended...
Guar gumNot Annotated
2,4-thiazolidinedioneThiazolidinedione has been investigated for the treatment of Type 2 Diabetes, Diabetes Mellitus, and DIABETES MELLITUS, TYPE 2.
SotagliflozinSotagliflozin has been used in trials studying the treatment of Renal impairment, Hepatic Impairment, Type 1 Diabetes Mellitus, and High Level of Sugar (Glucose) in the Blood.
EnglitazoneEnglitazone is a hypoglycemic agent.
SulfisoxazoleA sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections.
Insulin peglisproNot Annotated
Insulin porkA purified form of porcine insulin used to control hyperglycemia in diabetes mellitus.
Insulin degludecA long acting insulin used to treat hyperglycemia caused by type 1 and 2 diabetes mellitus.
NN344Investigated for use/treatment in diabetes mellitus type 1 and 2.
NBI-6024Investigated for use/treatment in diabetes mellitus type 1 and pediatric indications.
LinagliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus.
Insulin beefInsulin beef has been discontinued in the US and Canada since 2017.
CiglitazoneDeveloped by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class. Ciglitazone was never used as a medication, but it sparked interest in...
LobeglitazoneLobeglitazone was approved by the Ministry of Food and Drug Safety (South Korea) in 2013, and is being monitored by postmarketing surveillance until 2019. Lobeglitazone is not approved for use...
RivoglitazoneRivoglitazone (INN) is a thiazolidinedione undergoing research for use in the treatment of type 2 diabetes. It is being developed by Daiichi Sankyo Co.
NetoglitazoneNetoglitazone (MCC-555) is a hypoglycemic agent.
BalaglitazoneBalaglitazone has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
TroglitazoneFor the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
AcetohexamideUsed in the management of diabetes mellitus type 2 (adult-onset).
GliquidoneUsed in the treatment of diabetes mellitus type 2.
GlisoxepideFor the treatment of diabetes mellitus type 2.
GlibornurideGlibornuride is a sulfonylurea-type anti-diabetic drug.
CarbutamideNot Annotated
MetahexamideNot Annotated
GemigliptinGemigliptin is under investigation in Type 2 Diabetes Mellitus. Gemigliptin has been investigated for the treatment of Cancer and Cisplatin Adverse Reaction.
EvogliptinEvogliptin has been used in trials studying the treatment and screening of Osteoporosis, Renal Impairment, Type 2 Diabetes Mellitus, Diabetes Mellitis Type 2, and Diabetes Mellitus, Type 2.
GosogliptinGosogliptin has been used in trials studying the treatment of Renal Insufficiency, Chronic.
DutogliptinDutogliptin has been investigated for the treatment of Diabetes Mellitus, Type II.
CarmegliptinCarmegliptin has been used in trials studying the treatment of Diabetes Mellitus Type 2.
BisegliptinInvestigated for use/treatment in diabetes mellitus type 2.
AMG-222Investigated for use/treatment in diabetes mellitus type 2.
TeneligliptinTeneligliptin has been investigated for the treatment of Type 2 Diabetes Mellitus.
OmarigliptinOmarigliptin has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency.
AnagliptinAnagliptin is under investigation for the treatment of LDL Cholesterol, Coronary Disease, Diabetes Mellitus, Glycosylated Hemoglobin, and Dipeptidyl-Peptidase 4 Inhibitors.
VildagliptinA once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus.
TaspoglutideTaspoglutide is a pharmaceutical drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), under investigation for treatment of type 2 diabetes being codeveloped by Ipsen and Roche. In September 2010 Roche halted...
LixisenatideA GLP-1 receptor agonist used for the management of type 2 diabetes mellitus.
SemaglutideA glucagon-like peptide 1 receptor agonist used to improve glycemic control in type 2 diabetes mellitus.
AICA ribonucleotide5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate and analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has...
AllicinAllicin has been used in trials studying the treatment of Follicular Lymphoma.
IpragliflozinIpragliflozin is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.
ErtugliflozinA SGLT2 inhibitor used to treat type 2 diabetes mellitus.
Gastric inhibitory polypeptideGastric inhibitory polypeptide is under investigation in clinical trial NCT03081676 (The Effect of GIP and GLP-1 on Insulin and Glucagon Secretion in Patients With HNF1A-diabetes Treated With or Without Sulphonylurea).
Insulin tregopilcode text here
TofogliflozinTofogliflozin has been used in trials studying the treatment and prevention of Diabetes Mellitus Type 2.
Remogliflozin etabonateRemogliflozin etabonate has been used in trials studying the treatment and basic science of Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2.
TirzepatideTirzepatide is under investigation in clinical trial NCT03311724 (A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes).
Insulin argineNot Annotated
ZopolrestatNot Available
Drugs & Drug Targets
DrugTargetType
Insulin humanInsulin receptortarget
Insulin humanRetinoblastoma-associated proteintarget
Insulin humanInsulin-like growth factor 1 receptortarget
Insulin humanInsulin-degrading enzymeenzyme
Insulin humanNeuroendocrine convertase 2enzyme
Insulin humanNeuroendocrine convertase 1enzyme
Insulin humanCytochrome P450 1A2enzyme
Insulin humanCarboxypeptidase Etarget
Insulin lisproInsulin receptortarget
Insulin lisproInsulin-like growth factor 1 receptortarget
Insulin lisproCytochrome P450 1A2enzyme
Insulin glargineInsulin receptortarget
Insulin glargineInsulin-like growth factor 1 receptortarget
Insulin glargineCytochrome P450 1A2enzyme
GlimepirideATP-sensitive inward rectifier potassium channel 1target
GlimepirideATP-sensitive inward rectifier potassium channel 11target
GlimepirideCytochrome P450 2C9enzyme
GlimepirideATP-binding cassette sub-family C member 8target
GlimepirideBile salt export pumptransporter
DisopyramideSodium channel protein type 5 subunit alphatarget
DisopyramideAlpha-1-acid glycoprotein 1carrier
DisopyramideCytochrome P450 3A4enzyme
DisopyramideMuscarinic acetylcholine receptor M1target
DisopyramideMuscarinic acetylcholine receptor M2target
DisopyramideMuscarinic acetylcholine receptor M3target
DisopyramidePotassium voltage-gated channel subfamily D member 2target
DisopyramidePotassium voltage-gated channel subfamily D member 3target
DisopyramideSolute carrier family 22 member 2transporter
DisopyramideSolute carrier family 22 member 1transporter
DisopyramidePotassium voltage-gated channel subfamily H member 2target
DisopyramideAlpha-1-acid glycoprotein 2target
DisopyramideCytochrome P450 1A2enzyme
AcarboseMaltase-glucoamylase, intestinaltarget
AcarboseLysosomal alpha-glucosidasetarget
AcarboseSucrase-isomaltase, intestinaltarget
AcarbosePancreatic alpha-amylasetarget
Metformin5'-AMP-activated protein kinase subunit beta-1target
MetforminSolute carrier family 22 member 2transporter
MetforminSolute carrier family 22 member 1transporter
MetforminMultidrug and toxin extrusion protein 1transporter
MetforminEquilibrative nucleoside transporter 4transporter
MetforminSolute carrier family 22 member 3transporter
MetforminMultidrug and toxin extrusion protein 2transporter
MetforminElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialtarget
MetforminGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget
SulfadiazineCytochrome P450 2C9enzyme
SulfadiazineDihydropteroate synthetasetarget
SulfadiazineCytochrome P450 2C8enzyme
SulfadiazineCytochrome P450 3A4enzyme
RosiglitazonePeroxisome proliferator-activated receptor gammatarget
RosiglitazoneCytochrome P450 2C8enzyme
RosiglitazoneCytochrome P450 2C9enzyme
RosiglitazoneLong-chain-fatty-acid--CoA ligase 4target
RosiglitazoneSolute carrier organic anion transporter family member 1B1transporter
RosiglitazoneProstaglandin G/H synthase 1enzyme
RosiglitazoneCytochrome P450 1A2enzyme
RosiglitazoneCytochrome P450 2A6enzyme
RosiglitazoneCytochrome P450 2D6enzyme
RosiglitazoneSerum albumincarrier
RosiglitazonePeroxisome proliferator-activated receptor alphatarget
RosiglitazonePeroxisome proliferator-activated receptor deltatarget
RosiglitazoneRetinoic acid receptor RXR-alphatarget
RosiglitazoneRetinoic acid receptor RXR-betatarget
RosiglitazoneRetinoic acid receptor RXR-gammatarget
RosiglitazoneCytochrome P450 3A4enzyme
RosiglitazoneBile salt export pumptransporter
QuininePlatelet glycoprotein IXtarget
QuinineIntermediate conductance calcium-activated potassium channel protein 4target
QuinineCytochrome P450 3A4enzyme
QuinineCytochrome P450 3A5enzyme
QuinineCytochrome P450 1A1enzyme
QuinineCytochrome P450 2D6enzyme
QuinineCytochrome P450 1A2enzyme
QuinineCytochrome P450 2C8enzyme
QuinineCytochrome P450 2C9enzyme
QuinineCytochrome P450 2C19enzyme
QuinineCytochrome P450 2E1enzyme
QuinineCytochrome P450 3A7enzyme
QuinineSolute carrier family 22 member 2transporter
QuinineSolute carrier family 22 member 1transporter
QuinineSolute carrier family 22 member 5transporter
QuinineP-glycoprotein 1transporter
QuinineSolute carrier organic anion transporter family member 1A2transporter
QuinineSolute carrier family 22 member 4transporter
QuinineFe(II)-protoporphyrin IXtarget
QuinineSolute carrier organic anion transporter family member 1B1transporter
MiglitolMaltase-glucoamylase, intestinaltarget
MiglitolPancreatic alpha-amylaseenzyme
MiglitolLysosomal alpha-glucosidasetarget
MiglitolNeutral alpha-glucosidase ABtarget
MiglitolNeutral alpha-glucosidase Ctarget
ChlorpropamideATP-binding cassette sub-family C member 8target
ChlorpropamideSolute carrier family 15 member 1transporter
ChlorpropamideSolute carrier family 15 member 2transporter
ChlorpropamideSolute carrier family 22 member 6transporter
ChlorpropamideCytochrome P450 2C9enzyme
ChlorpropamideCytochrome P450 2C19enzyme
ChlorpropamideProstaglandin G/H synthase 1enzyme
NateglinideATP-binding cassette sub-family C member 8target
NateglinideCytochrome P450 3A4enzyme
NateglinideCytochrome P450 2C9enzyme
NateglinidePeroxisome proliferator-activated receptor gammatarget
NateglinideCytochrome P450 3A5enzyme
NateglinideCytochrome P450 3A7enzyme
NateglinideSolute carrier family 15 member 1transporter
NateglinideSolute carrier family 15 member 2transporter
NateglinideSolute carrier family 22 member 6transporter
NateglinideMonocarboxylate transporter 1transporter
NateglinideProstaglandin G/H synthase 1enzyme
NateglinideUDP-glucuronosyltransferase 1-9enzyme
NateglinideCytochrome P450 2D6enzyme
NateglinideMultidrug resistance-associated protein 4transporter
NateglinideSerum albumincarrier
NateglinideAlpha-1-acid glycoprotein 1carrier
PentamidineDNAtarget
PentamidineCytochrome P450 2C19enzyme
PentamidinetRNA (cytosine(38)-C(5))-methyltransferasetarget
PentamidineCytochrome P450 2D6enzyme
PentamidineCytochrome P450 1A1enzyme
PentamidineCytochrome P450 3A5enzyme
PentamidineCytochrome P450 4A11enzyme
MifepristoneProgesterone receptortarget
MifepristoneGlucocorticoid receptortarget
MifepristoneCytochrome P450 3A4enzyme
MifepristoneCytochrome P450 3A5enzyme
MifepristoneP-glycoprotein 1transporter
MifepristoneMultidrug resistance-associated protein 1transporter
MifepristoneCytochrome P450 2D6enzyme
MifepristoneProstate-specific antigentarget
MifepristoneNuclear receptor subfamily 1 group I member 2target
MifepristoneBile salt export pumptransporter
MifepristoneCytochrome P450 2C8enzyme
MifepristoneCytochrome P450 2C9enzyme
MifepristoneSolute carrier organic anion transporter family member 1B1transporter
MifepristoneSolute carrier organic anion transporter family member 1B3transporter
TolazamideSulfonylurea receptor 1, Kir6.2target
TolazamideCytochrome P450 2C9enzyme
RepaglinideATP-binding cassette sub-family C member 8target
RepaglinideCytochrome P450 2C8enzyme
RepaglinidePeroxisome proliferator-activated receptor gammatarget
RepaglinideCytochrome P450 3A4enzyme
RepaglinideSerum albumincarrier
RepaglinideSolute carrier organic anion transporter family member 1B1transporter
RepaglinideBile salt export pumptransporter
SulfamethoxazoleCytochrome P450 2C9enzyme
SulfamethoxazoleSerum albumincarrier
SulfamethoxazoleArylamine N-acetyltransferase 1enzyme
SulfamethoxazoleArylamine N-acetyltransferase 2enzyme
SulfamethoxazoleDihydropteroate synthasetarget
SulfamethoxazoleCytochrome P450 3A4enzyme
SulfamethoxazoleBile salt export pumptransporter
GlyburideATP-binding cassette sub-family C member 9target
GlyburideBile salt export pumptarget
GlyburideATP-binding cassette sub-family A member 1target
GlyburideCystic fibrosis transmembrane conductance regulatortarget
GlyburideSulfonylurea receptor 1, Kir6.2target
GlyburideCytochrome P450 2C9enzyme
GlyburideCanalicular multispecific organic anion transporter 2transporter
GlyburideBile salt export pumptransporter
GlyburideP-glycoprotein 1transporter
GlyburideMultidrug resistance-associated protein 1transporter
GlyburideSolute carrier family 15 member 1transporter
GlyburideSolute carrier organic anion transporter family member 1A2transporter
GlyburideSolute carrier family 15 member 2transporter
GlyburideSolute carrier family 22 member 6transporter
GlyburideCanalicular multispecific organic anion transporter 1transporter
GlyburideATP-binding cassette sub-family G member 2transporter
GlyburideSolute carrier family 22 member 7transporter
GlyburideSolute carrier organic anion transporter family member 2B1transporter
GlyburideCytochrome P450 2C19enzyme
GlyburideCytochrome P450 3A4enzyme
GlyburideSerum albumincarrier
GlyburideMitochondrial ATP-sensitive potassium channeltarget
GlyburideCarnitine O-palmitoyltransferase 1, liver isoformtarget
GlyburideCytochrome P450 3A7enzyme
GlyburideCytochrome P450 3A5enzyme
GlyburideTransient receptor potential cation channel subfamily M member 4target
GlipizideCytochrome P450 2C9enzyme
GlipizidePeroxisome proliferator-activated receptor gammatarget
GlipizideATP-binding cassette sub-family C member 8target
GlipizideUDP-glucuronosyltransferase 1-1enzyme
GlipizideBile salt export pumptransporter
GlipizideSerum albumincarrier
GliclazideATP-binding cassette sub-family C member 8target
GliclazideSerum albumincarrier
GliclazideVascular endothelial growth factor Atarget
GliclazideCytochrome P450 2C9enzyme
GliclazideCytochrome P450 2C19enzyme
TolbutamideATP-sensitive inward rectifier potassium channel 1target
TolbutamideCytochrome P450 2C19enzyme
TolbutamideCytochrome P450 2C9enzyme
TolbutamideCytochrome P450 2C8enzyme
TolbutamideATP-binding cassette sub-family C member 8target
TolbutamideSolute carrier family 15 member 1transporter
TolbutamideSolute carrier organic anion transporter family member 1A2transporter
TolbutamideSolute carrier family 15 member 2transporter
TolbutamideSolute carrier family 22 member 6transporter
TolbutamideSolute carrier organic anion transporter family member 2B1transporter
TolbutamideCytochrome P450 2C18enzyme
TolbutamideSerum albumincarrier
PioglitazonePeroxisome proliferator-activated receptor gammatarget
PioglitazoneCytochrome P450 2C8enzyme
PioglitazoneCytochrome P450 3A4enzyme
PioglitazoneSolute carrier organic anion transporter family member 1B3transporter
PioglitazoneSolute carrier organic anion transporter family member 1B1transporter
PioglitazoneAmine oxidase [flavin-containing] Btarget
PioglitazoneSerum albumincarrier
PioglitazoneCytochrome P450 1A1enzyme
BromocriptineDopamine D2 receptortarget
BromocriptineCytochrome P450 3A4enzyme
Bromocriptine5-hydroxytryptamine receptor 1Dtarget
BromocriptineAlpha-2A adrenergic receptortarget
BromocriptineDopamine D3 receptortarget
Bromocriptine5-hydroxytryptamine receptor 1Atarget
BromocriptineAlpha-2C adrenergic receptortarget
BromocriptineAlpha-2B adrenergic receptortarget
Bromocriptine5-hydroxytryptamine receptor 2Btarget
BromocriptineDopamine D4 receptortarget
Bromocriptine5-hydroxytryptamine receptor 2Atarget
Bromocriptine5-hydroxytryptamine receptor 1Btarget
Bromocriptine5-hydroxytryptamine receptor 2Ctarget
BromocriptineDopamine D5 receptortarget
BromocriptineDopamine D1 receptortarget
BromocriptineAlpha-1A adrenergic receptortarget
BromocriptineAlpha-1B adrenergic receptortarget
BromocriptineAlpha-1D adrenergic receptortarget
Bromocriptine5-hydroxytryptamine receptor 7target
BromocriptineP-glycoprotein 1transporter
SitagliptinDipeptidyl peptidase 4target
SitagliptinCytochrome P450 3A4enzyme
SitagliptinCytochrome P450 2C8enzyme
SitagliptinP-glycoprotein 1transporter
SitagliptinSolute carrier family 22 member 8transporter
SunitinibPlatelet-derived growth factor receptor betatarget
SunitinibVascular endothelial growth factor receptor 1target
SunitinibVascular endothelial growth factor receptor 2target
SunitinibVascular endothelial growth factor receptor 3target
SunitinibMast/stem cell growth factor receptor Kittarget
SunitinibReceptor-type tyrosine-protein kinase FLT3target
SunitinibMacrophage colony-stimulating factor 1 receptortarget
SunitinibPlatelet-derived growth factor receptor alphatarget
SunitinibCytochrome P450 3A4enzyme
SunitinibCytochrome P450 3A5enzyme
SunitinibCytochrome P450 3A7enzyme
SunitinibMultidrug resistance-associated protein 4transporter
SunitinibP-glycoprotein 1transporter
SunitinibCanalicular multispecific organic anion transporter 1transporter
SunitinibATP-binding cassette sub-family G member 2transporter
ExenatideGlucagon-like peptide 1 receptortarget
ExenatideSerum albumincarrier
ExenatideDipeptidyl peptidase 4enzyme
MecaserminInsulin-like growth factor 1 receptortarget
MecaserminInsulin-like growth factor-binding protein 3target
MecaserminInsulin receptortarget
MecaserminCation-independent mannose-6-phosphate receptortarget
MecaserminInsulin-like growth factor-binding protein 3carrier
MecaserminInsulin-like growth factor-binding protein complex acid labile subunitcarrier
MecaserminInsulin-like growth factor-binding protein 1carrier
MecaserminInsulin-like growth factor-binding protein 2carrier
MecaserminInsulin-like growth factor-binding protein 4carrier
MecaserminInsulin-like growth factor-binding protein 5carrier
MecaserminInsulin-like growth factor-binding protein 6carrier
PramlintideReceptor activity-modifying protein 1target
PramlintideReceptor activity-modifying protein 2target
PramlintideReceptor activity-modifying protein 3target
PramlintideCalcitonin receptortarget
Insulin aspartInsulin receptortarget
Insulin aspartInsulin-like growth factor 1 receptortarget
Insulin aspartCytochrome P450 1A2enzyme
Insulin detemirInsulin receptortarget
Insulin detemirSerum albumincarrier
Insulin detemirInsulin-like growth factor 1 receptortarget
Insulin detemirCytochrome P450 1A2enzyme
Insulin glulisineInsulin receptortarget
Insulin glulisineInsulin-like growth factor 1 receptortarget
Insulin glulisineCytochrome P450 1A2enzyme
AlogliptinDipeptidyl peptidase 4target
AlogliptinCytochrome P450 3A4enzyme
AlogliptinCytochrome P450 2D6enzyme
DapagliflozinSodium/glucose cotransporter 2target
DapagliflozinCytochrome P450 1A1enzyme
DapagliflozinCytochrome P450 1A2enzyme
DapagliflozinCytochrome P450 2A6enzyme
DapagliflozinCytochrome P450 2C9enzyme
DapagliflozinCytochrome P450 2D6enzyme
DapagliflozinCytochrome P450 3A4enzyme
DapagliflozinUDP-glucuronosyltransferase 1-9enzyme
DapagliflozinUDP-glucuronosyltransferase 2B4enzyme
DapagliflozinUDP-glucuronosyltransferase 2B7enzyme
DapagliflozinP-glycoprotein 1transporter
SaxagliptinDipeptidyl peptidase 4target
SaxagliptinCytochrome P450 3A4enzyme
SaxagliptinCytochrome P450 3A5enzyme
SaxagliptinMultidrug resistance-associated protein 1transporter
SaxagliptinSolute carrier organic anion transporter family member 4C1transporter
SaxagliptinSolute carrier family 22 member 8transporter
LiraglutideGlucagon-like peptide 1 receptortarget
LiraglutideDipeptidyl peptidase 4enzyme
LiraglutideNeprilysinenzyme
LiraglutideSerum albumincarrier
CanagliflozinUDP-glucuronosyltransferase 1-9enzyme
CanagliflozinUDP-glucuronosyltransferase 2B4enzyme
CanagliflozinCytochrome P450 3A4enzyme
CanagliflozinSodium/glucose cotransporter 2target
CanagliflozinP-glycoprotein 1transporter
CanagliflozinCanalicular multispecific organic anion transporter 1transporter
CanagliflozinAlpha-1-acid glycoprotein 1carrier
CanagliflozinATP-binding cassette sub-family G member 2transporter
EmpagliflozinSodium/glucose cotransporter 2target
EmpagliflozinUDP-glucuronosyltransferase 2B7enzyme
EmpagliflozinUDP-glucuronosyltransferase 1-3enzyme
EmpagliflozinUDP-glucuronosyltransferase 1-8enzyme
EmpagliflozinUDP-glucuronosyltransferase 1-9enzyme
EmpagliflozinP-glycoprotein 1transporter
EmpagliflozinATP-binding cassette sub-family G member 2transporter
EmpagliflozinSolute carrier family 22 member 8transporter
EmpagliflozinSolute carrier organic anion transporter family member 1B1transporter
EmpagliflozinSolute carrier organic anion transporter family member 1B3transporter
AlbiglutideGlucagon-like peptide 1 receptortarget
DulaglutideGlucagon-like peptide 1 receptortarget
Phenformin5'-AMP-activated protein kinase catalytic subunit alpha-1target
PhenforminCytochrome P450 2D6enzyme
PhenforminSolute carrier family 22 member 2transporter
PhenforminSolute carrier family 22 member 1transporter
PhenforminATP-sensitive inward rectifier potassium channel 8target
MitiglinideATP-binding cassette sub-family C member 8target
MitiglinidePeroxisome proliferator-activated receptor gammatarget
MitiglinideUDP-glucuronosyltransferase 1-3enzyme
MitiglinideUDP-glucuronosyltransferase 2B7enzyme
GlymidineATP-sensitive inward rectifier potassium channel 1target
GlymidineATP-binding cassette sub-family C member 8target
BuforminSolute carrier family 22 member 1transporter
VogliboseMaltase-glucoamylase, intestinaltarget
SulfisoxazoleDihydropteroate synthasetarget
SulfisoxazoleCytochrome P450 2C9enzyme
Insulin peglisproCytochrome P450 1A2enzyme
Insulin porkInsulin receptortarget
Insulin porkHLA class II histocompatibility antigen, DQ alpha 2 chaintarget
Insulin porkHLA class II histocompatibility antigen, DQ beta 1 chaintarget
Insulin porkRetinoblastoma-associated proteintarget
Insulin porkCathepsin Dtarget
Insulin porkInsulin-like growth factor 1 receptortarget
Insulin porkInsulin-degrading enzymetarget
Insulin porkNeuroendocrine convertase 2target
Insulin porkCarboxypeptidase Etarget
Insulin porkNeuroendocrine convertase 1target
Insulin porkProtein NOV homologtarget
Insulin porkLow-density lipoprotein receptor-related protein 2target
Insulin porkInsulin-like growth factor-binding protein 7target
Insulin porkSynaptotagmin-like protein 4target
Insulin porkCytochrome P450 1A2enzyme
Insulin degludecInsulin receptortarget
Insulin degludecInsulin-like growth factor 1 receptortarget
Insulin degludecSerum albumincarrier
Insulin degludecCytochrome P450 1A2enzyme
NN344Insulin receptortarget
NN344Cytochrome P450 1A2enzyme
LinagliptinDipeptidyl peptidase 4target
LinagliptinCytochrome P450 3A4enzyme
LinagliptinP-glycoprotein 1transporter
LinagliptinSolute carrier family 22 member 1transporter
LinagliptinSolute carrier family 22 member 2transporter
LinagliptinSolute carrier family 22 member 3transporter
Insulin beefCytochrome P450 1A2enzyme
CiglitazonePeroxisome proliferator-activated receptor gammatarget
CiglitazoneCytochrome P450 3A4enzyme
CiglitazoneCytochrome P450 2C8enzyme
LobeglitazoneSolute carrier organic anion transporter family member 1B1transporter
LobeglitazoneSolute carrier organic anion transporter family member 3A1transporter
LobeglitazoneP-glycoprotein 1transporter
LobeglitazoneCytochrome P450 1A2enzyme
LobeglitazoneCytochrome P450 2C9enzyme
LobeglitazoneCytochrome P450 2C19enzyme
LobeglitazonePeroxisome proliferator-activated receptor gammatarget
LobeglitazoneCytochrome P450 3A4enzyme
LobeglitazoneCytochrome P450 2C8enzyme
RivoglitazoneCytochrome P450 3A4enzyme
RivoglitazoneCytochrome P450 2C8enzyme
NetoglitazoneCytochrome P450 3A4enzyme
NetoglitazoneCytochrome P450 2C8enzyme
BalaglitazoneCytochrome P450 3A4enzyme
BalaglitazoneCytochrome P450 2C8enzyme
TroglitazonePeroxisome proliferator-activated receptor gammatarget
TroglitazoneLong-chain-fatty-acid--CoA ligase 4target
TroglitazonePlasminogen activator inhibitor 1target
TroglitazoneEquilibrative nucleoside transporter 1target
TroglitazoneCytochrome P450 3A4enzyme
TroglitazoneCytochrome P450 2C19enzyme
TroglitazoneUDP-glucuronosyltransferase 1-1enzyme
TroglitazoneCytochrome P450 2C8enzyme
TroglitazoneBile salt export pumptransporter
TroglitazoneSolute carrier organic anion transporter family member 1B1transporter
TroglitazoneEstrogen-related receptor gammatarget
TroglitazoneSteroid hormone receptor ERR1target
TroglitazoneCytochrome P450 19A1enzyme
TroglitazoneCytochrome P450 1A1enzyme
TroglitazoneCytochrome P450 2B6enzyme
TroglitazoneCytochrome P450 2C9enzyme
TroglitazoneCytochrome P450 3A5enzyme
TroglitazoneCytochrome P450 3A7enzyme
TroglitazoneUDP-glucuronosyltransferase 1-3enzyme
TroglitazoneUDP-glucuronosyltransferase 1-4enzyme
TroglitazoneUDP-glucuronosyltransferase 1-6enzyme
TroglitazoneUDP-glucuronosyltransferase 1-7enzyme
TroglitazoneUDP-glucuronosyltransferase 1-8enzyme
TroglitazoneUDP-glucuronosyltransferase 1-9enzyme
TroglitazoneUDP-glucuronosyltransferase 1-10enzyme
TroglitazoneUDP-glucuronosyltransferase 2B7enzyme
TroglitazoneUDP-glucuronosyltransferase 2B15enzyme
TroglitazonePeroxisome proliferator-activated receptor deltatarget
TroglitazonePeroxisome proliferator-activated receptor alphatarget
TroglitazoneGlutathione S-transferase Ptarget
AcetohexamideATP-sensitive inward rectifier potassium channel 1target
AcetohexamideCarbonyl reductase [NADPH] 1enzyme
AcetohexamideSerum albumincarrier
AcetohexamideCytochrome P450 2C9enzyme
GliquidoneATP-binding cassette sub-family C member 8target
GliquidoneATP-sensitive inward rectifier potassium channel 8target
GliquidoneCytochrome P450 2C9enzyme
GlisoxepideATP-sensitive inward rectifier potassium channel 8target
GlisoxepideCytochrome P450 2C9enzyme
GlibornurideCytochrome P450 2C9enzyme
CarbutamideCytochrome P450 2C9enzyme
MetahexamideCytochrome P450 2C9enzyme
GosogliptinDipeptidyl peptidase 4target
DutogliptinDipeptidyl peptidase 4target
BisegliptinDipeptidyl peptidase 4target
AMG-222Dipeptidyl peptidase 4target
VildagliptinDipeptidyl peptidase 4target
LixisenatideGlucagon-like peptide 1 receptortarget
SemaglutideSerum albumincarrier
SemaglutideDipeptidyl peptidase 4enzyme
SemaglutideNeprilysinenzyme
SemaglutideGlucagon-like peptide 1 receptortarget
SemaglutideLipoprotein lipaseenzyme
SemaglutideAlpha-amylase 1enzyme
AICA ribonucleotideBifunctional purine biosynthesis protein PURHtarget
ErtugliflozinUDP-glucuronosyltransferase 1-9enzyme
ErtugliflozinUDP-glucuronosyltransferase 2B7enzyme
ErtugliflozinSodium/glucose cotransporter 2target
ErtugliflozinP-glycoprotein 1transporter
ErtugliflozinATP-binding cassette sub-family G member 2transporter
ErtugliflozinSerum albumincarrier
ErtugliflozinUDP-glucuronosyltransferase 1-1enzyme
ErtugliflozinUDP-glucuronosyltransferase 1-4enzyme
Insulin tregopilCytochrome P450 1A2enzyme
ZopolrestatAldo-keto reductase family 1 member B10target
ZopolrestatAldose reductasetarget