Drugs Used in Diabetes

DrugDrug NameDrug Indication
DB00030Insulin humanHuman insulin is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus.
DB00046Insulin LisproInsulin lispro is indicated to improve glycemic control in adults and children with diabetes mellitus.
DB00047Insulin glargineInsulin glargine is indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus.
DB00071Insulin PorkFor the treatment of type I and II diabetes mellitus.
DB00197TroglitazoneFor the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
DB00222GlimepirideGlimepiride is indicated for the management of type 2 diabetes in adults as an adjunct to diet and exercise to improve glycemic control as monotherapy. It may also be indicated for use in combination with metformin or insulin to lower blood glucose in patients with type 2 diabetes whose high blood sugar levels cannot be controlled by diet and exercise in conjunction with an oral hypoglycemic (a drug used to lower blood sugar levels) agent alone [F4540].
DB00284AcarboseFor treatment and management of diabetes type II (used in combination therapy as a second or third line agent)
DB00331Metformin**Metformin tablet** Metformin is indicated as an adjunct to diet and exercise to increase glycemic control in _adults and pediatric patients_ 10 years of age and older diagnosed with type 2 diabetes mellitus [FDA label]. **Metformin extended-release tablet (XR)** The extended-release form is indicated as an adjunct to diet and exercise to improve glycemic control in only _adults_ with type 2 diabetes mellitus. Safety in children has not been determined to this date [FDA label].
DB00412RosiglitazoneRosiglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
DB00414AcetohexamideUsed in the management of diabetes mellitus type 2 (adult-onset).
DB00491MiglitolFor use as an adjunct to diet to improve glycemic control in patients with non-insulin-dependent diabetes mellitus (NIDDM) whose hyperglycemia cannot be managed with diet alone.
DB00672ChlorpropamideFor treatment of NIDDM in conjunction with diet and exercise.
DB00731NateglinideFor the treatment of non-insulin dependent-diabetes mellitus in conjunction with diet and exercise.
DB00839TolazamideFor use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.
DB00912RepaglinideAs an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
DB00914PhenforminFor the reatment of type II diabetes mellitus.
DB01016GlyburideGlyburide is indicated alone or as part of combination product with metformin, as an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus.[L8120,L8123]
DB01067GlipizideIndicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.[label]
DB01120GliclazideFor the treatment of NIDDM in conjunction with diet and exercise.
DB01132PioglitazonePioglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus [FDA Label].
DB01251GliquidoneUsed in the treatment of diabetes mellitus type 2.
DB01252MitiglinideFor the treatment of type 2 diabetes.
DB01261SitagliptinSitagliptin is indicated for the management of glycemic control in type 2 diabetes mellitus along with diet and exercise[Label].
DB01276ExenatideExenatide is indicated for improving glycemic control in adults with type 2 diabetes mellitus along with diet and exercise[Label].
DB01278PramlintideFor the treatment of type 1 and type 2 diabetes mellitus as an adjunct to preprandial insulin therapy in patients without adequate glycemic control of insulin therapy.
DB01289GlisoxepideFor the treatment of diabetes mellitus type 2.
DB01306Insulin AspartInsulin aspart is indicated to improve glycemic control in adults and children with diabetes mellitus.
DB01307Insulin DetemirInsulin detemir is indicated to improve glycemic control in adults and children with diabetes mellitus.
DB01309Insulin GlulisineInsulin glulisine is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus.
DB01382GlymidineGlycodiazine is used concomitantly with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.
DB02383TolrestatFor the pharmacological control of certain diabetic complications.
DB04830BuforminNot Available
DB04876VildagliptinUsed to reduce hyperglycemia in type 2 diabetes mellitus.
DB04878VogliboseFor the treatment of diabetes. It is specifically used for lowering post-prandial blood glucose levels thereby reducing the risk of macrovascular complications.
DB06203AlogliptinIndicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
DB06292DapagliflozinDapagliflozin is indicated to improve glycemic control in adult patients with type 2 diabetes mellitus along with diet and exercise[Label,A6757,A6758].
DB06335SaxagliptinTreatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.
DB06655LiraglutideLiraglutide is indicated in combination with diet and exercise to improve glycemic control in patients 10 years and older with type 2 diabetes mellitus[Label,L6718]. It is also indicated to reduce the risk of major adverse cardiovascular events in patients with type 2 diabetes mellitus as well as cardiovascular disease[Label].
DB08882LinagliptinLinagliptin is indicated for the treatment of type II diabetes in addition to diet and exercise[FDA Label]. It should not be used to treat type I diabetes or in diabetic ketoacidosis[FDA Label].
DB08907CanagliflozinThis drug is used in conjunction with diet and exercise to increase glycemic control in adults diagnosed with type 2 diabetes mellitus [FDA label]. Another indication for canagliflozin is for the prevention of major cardiovascular events (myocardial infarction, stroke, or death due to a cardiovascular cause) in patients with type 2 diabetes [FDA label], [L5897]. It is important to note that this drug is **not** indicated for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis [FDA label].
DB08962GlibornurideNot Available
DB09022BenfluorexNot Available
DB09038EmpagliflozinEmpagliflozin is indicated as an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes.
DB09043AlbiglutideIndicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
DB09045DulaglutideIndicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
DB09265LixisenatideFor use as an antihyperglycemic agent in the treatment of T2DM [FDA Label].
DB09456Insulin BeefNot Available
DB09564Insulin DegludecInsulin degludec is indicated to improve glycemic control in patients 1 year of age and older with diabetes mellitus.
DB12412GemigliptinNot Available
DB13406CarbutamideNot Available
DB13446Guar gumNot Available
DB13675MetahexamideNot Available
DB00641SimvastatinSimvastatin is indicated for the treatment of hyperlipidemia to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL‑C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C).[F4655, F4658] This includes the treatment of primary hyperlipidemia (Fredrickson type IIa, heterozygous familial and nonfamilial), mixed dyslipidemia (Fredrickson type IIb), hypertriglyceridemia (Fredrickson type IV hyperlipidemia), primary dysbetalipoproteinemia (Fredrickson type III hyperlipidemia), homozygous familial hypercholesterolemia (HoFH) as an adjunct to other lipid-lowering treatments, as well as adolescent patients with Heterozygous Familial Hypercholesterolemia (HeFH).[F4655, F4658] Simvastatin is also indicated to reduce the risk of cardiovascular morbidity and mortality including myocardial infarction, stroke, and the need for revascularization procedures. It is primarily used in patients at high risk of coronary events because of existing coronary heart disease, diabetes, peripheral vessel disease, history of stroke or other cerebrovascular disease.[F4655, F4658] Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a moderate to high risk of development of CVD. Statin-indicated conditions include diabetes mellitus, clinical atherosclerosis (including myocardial infarction, acute coronary syndromes, stable angina, documented coronary artery disease, stroke, trans ischemic attack (TIA), documented carotid disease, peripheral artery disease, and claudication), abdominal aortic aneurysm, chronic kidney disease, and severely elevated LDL-C levels.[A181087, A181406]
DB01124TolbutamideFor treatment of NIDDM (non-insulin-dependent diabetes mellitus) in conjunction with diet and exercise.
DB01098RosuvastatinThe FDA monograph states that rosuvastatin is indicated as an adjunct to diet in the treatment of triglyceridemia, Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia), and Homozygous Familial Hypercholesterolemia.[F4649] The Health Canada monograph for rosuvastatin further specifies that rosuvastatin is indicated for the reduction of elevated total cholesterol (Total-C), LDL-C, ApoB, the Total-C/HDL-C ratio and triglycerides (TG) and for increasing HDL-C in hyperlipidemic and dyslipidemic conditions when response to diet and exercise alone has been inadequate. It is also indicated for the prevention of major cardiovascular events (including risk of myocardial infarction, nonfatal stroke, and coronary artery revascularization) in adult patients without documented history of cardiovascular or cerebrovascular events, but with at least two conventional risk factors for cardiovascular disease.[F4652] Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a moderate to high risk of development of CVD. Statin-indicated conditions include diabetes mellitus, clinical atherosclerosis (including myocardial infarction, acute coronary syndromes, stable angina, documented coronary artery disease, stroke, trans ischemic attack (TIA), documented carotid disease, peripheral artery disease, and claudication), abdominal aortic aneurysm, chronic kidney disease, and severely elevated LDL-C levels.[A181087, A181406]
DB11698IpragliflozinNot Available
DB11827ErtugliflozinErtugliflozin as a monotherapy is indicated to improve the glycemic control in adult patients with type 2 diabetes.[FDA label] Ertugliflozin, in combination with metformin hydrochloride, is indicated to improve glycemic control in patients with diabetes type 2 who are not controlled on a regimen of ertugliflozin or metformin or in patients who are already treated with both ertugliflozin and metformin.[L1134] The administration of ertugliflozin in combination with sitagliptin is indicated to improve glycemic control in adult patients with type 2 diabetes when treatment with ertugliflozin and sitagliptin is appropriate.[L1135] It is pointed out that the use of ertugliflozin has to be an adjunct therapy to the use of diet and exercise. The type 2 diabetes mellitus is characterized by insulin resistance in muscle and liver, which results in the elevation of glucose levels in blood, or by presence of insulin deficiency. The insulin resistance is related to genetic factors, obesity, sedentary lifestyle or/and aging. This increase in the blood glucose can cause severe damage to kidney, eyes and vascular system.[A31582]
DB12625EvogliptinNot Available
DB13928SemaglutideSemaglutide is indicated to improve glycemic control in adults diagnosed with type 2 diabetes mellitus, and is used as an adjunct to diet and exercise.[L8678,L8681] It is important to note that semaglutide is not a suitable first-line drug for diabetes that has not been controlled by diet and exercise. In addition, it has not been studied in patients with pancreatitis. Semaglutide is not intended for use in patients with type 1 diabetes or to treat diabetic ketoacidosis.[L8678]
DrugDrug NameTargetType
DB00030Insulin humanInsulin receptortarget
DB00030Insulin humanRetinoblastoma-associated proteintarget
DB00030Insulin humanInsulin-like growth factor 1 receptortarget
DB00030Insulin humanInsulin-degrading enzymeenzyme
DB00030Insulin humanNeuroendocrine convertase 2enzyme
DB00030Insulin humanNeuroendocrine convertase 1enzyme
DB00030Insulin humanCytochrome P450 1A2enzyme
DB00030Insulin humanCarboxypeptidase Etarget
DB00046Insulin LisproInsulin receptortarget
DB00046Insulin LisproInsulin-like growth factor 1 receptortarget
DB00046Insulin LisproCytochrome P450 1A2enzyme
DB00047Insulin glargineInsulin receptortarget
DB00047Insulin glargineInsulin-like growth factor 1 receptortarget
DB00047Insulin glargineCytochrome P450 1A2enzyme
DB00071Insulin PorkInsulin receptortarget
DB00071Insulin PorkHLA class II histocompatibility antigen, DQ alpha 2 chaintarget
DB00071Insulin PorkHLA class II histocompatibility antigen, DQ beta 1 chaintarget
DB00071Insulin PorkRetinoblastoma-associated proteintarget
DB00071Insulin PorkCathepsin Dtarget
DB00071Insulin PorkInsulin-like growth factor 1 receptortarget
DB00071Insulin PorkInsulin-degrading enzymetarget
DB00071Insulin PorkNeuroendocrine convertase 2target
DB00071Insulin PorkCarboxypeptidase Etarget
DB00071Insulin PorkNeuroendocrine convertase 1target
DB00071Insulin PorkProtein NOV homologtarget
DB00071Insulin PorkLow-density lipoprotein receptor-related protein 2target
DB00071Insulin PorkInsulin-like growth factor-binding protein 7target
DB00071Insulin PorkSynaptotagmin-like protein 4target
DB00071Insulin PorkCytochrome P450 1A2enzyme
DB00197TroglitazonePeroxisome proliferator-activated receptor gammatarget
DB00197TroglitazoneLong-chain-fatty-acid--CoA ligase 4target
DB00197TroglitazonePlasminogen activator inhibitor 1target
DB00197TroglitazoneEquilibrative nucleoside transporter 1target
DB00197TroglitazoneCytochrome P450 3A4enzyme
DB00197TroglitazoneCytochrome P450 2C19enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-1enzyme
DB00197TroglitazoneCytochrome P450 2C8enzyme
DB00197TroglitazoneBile salt export pumptransporter
DB00197TroglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB00197TroglitazoneEstrogen-related receptor gammatarget
DB00197TroglitazoneSteroid hormone receptor ERR1target
DB00197TroglitazoneCytochrome P450 19A1enzyme
DB00197TroglitazoneCytochrome P450 1A1enzyme
DB00197TroglitazoneCytochrome P450 2B6enzyme
DB00197TroglitazoneCytochrome P450 2C9enzyme
DB00197TroglitazoneCytochrome P450 3A5enzyme
DB00197TroglitazoneCytochrome P450 3A7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-3enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-4enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-6enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-8enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-9enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-10enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 2B7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 2B15enzyme
DB00197TroglitazonePeroxisome proliferator-activated receptor deltatarget
DB00197TroglitazonePeroxisome proliferator-activated receptor alphatarget
DB00197TroglitazoneGlutathione S-transferase Ptarget
DB00222GlimepirideATP-sensitive inward rectifier potassium channel 1target
DB00222GlimepirideATP-sensitive inward rectifier potassium channel 11target
DB00222GlimepirideCytochrome P450 2C9enzyme
DB00222GlimepirideATP-binding cassette sub-family C member 8target
DB00222GlimepirideBile salt export pumptransporter
DB00284AcarboseMaltase-glucoamylase, intestinaltarget
DB00284AcarboseLysosomal alpha-glucosidasetarget
DB00284AcarboseSucrase-isomaltase, intestinaltarget
DB00284AcarbosePancreatic alpha-amylasetarget
DB00331Metformin5'-AMP-activated protein kinase subunit beta-1target
DB00331MetforminSolute carrier family 22 member 2transporter
DB00331MetforminSolute carrier family 22 member 1transporter
DB00331MetforminMultidrug and toxin extrusion protein 1transporter
DB00331MetforminEquilibrative nucleoside transporter 4transporter
DB00331MetforminSolute carrier family 22 member 3transporter
DB00331MetforminMultidrug and toxin extrusion protein 2transporter
DB00331MetforminElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialtarget
DB00331MetforminGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget
DB00412RosiglitazonePeroxisome proliferator-activated receptor gammatarget
DB00412RosiglitazoneCytochrome P450 2C8enzyme
DB00412RosiglitazoneCytochrome P450 2C9enzyme
DB00412RosiglitazoneLong-chain-fatty-acid--CoA ligase 4target
DB00412RosiglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB00412RosiglitazoneProstaglandin G/H synthase 1enzyme
DB00412RosiglitazoneCytochrome P450 1A2enzyme
DB00412RosiglitazoneCytochrome P450 2A6enzyme
DB00412RosiglitazoneCytochrome P450 2D6enzyme
DB00412RosiglitazoneSerum albumincarrier
DB00412RosiglitazonePeroxisome proliferator-activated receptor alphatarget
DB00412RosiglitazonePeroxisome proliferator-activated receptor deltatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-alphatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-betatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-gammatarget
DB00412RosiglitazoneCytochrome P450 3A4enzyme
DB00412RosiglitazoneBile salt export pumptransporter
DB00414AcetohexamideATP-sensitive inward rectifier potassium channel 1target
DB00414AcetohexamideCarbonyl reductase [NADPH] 1enzyme
DB00414AcetohexamideSerum albumincarrier
DB00414AcetohexamideCytochrome P450 2C9enzyme
DB00491MiglitolMaltase-glucoamylase, intestinaltarget
DB00491MiglitolPancreatic alpha-amylaseenzyme
DB00491MiglitolLysosomal alpha-glucosidasetarget
DB00491MiglitolNeutral alpha-glucosidase ABtarget
DB00491MiglitolNeutral alpha-glucosidase Ctarget
DB00672ChlorpropamideATP-binding cassette sub-family C member 8target
DB00672ChlorpropamideSolute carrier family 15 member 1transporter
DB00672ChlorpropamideSolute carrier family 15 member 2transporter
DB00672ChlorpropamideSolute carrier family 22 member 6transporter
DB00672ChlorpropamideCytochrome P450 2C9enzyme
DB00672ChlorpropamideCytochrome P450 2C19enzyme
DB00672ChlorpropamideProstaglandin G/H synthase 1enzyme
DB00731NateglinideATP-binding cassette sub-family C member 8target
DB00731NateglinideCytochrome P450 3A4enzyme
DB00731NateglinideCytochrome P450 2C9enzyme
DB00731NateglinidePeroxisome proliferator-activated receptor gammatarget
DB00731NateglinideCytochrome P450 3A5enzyme
DB00731NateglinideCytochrome P450 3A7enzyme
DB00731NateglinideSolute carrier family 15 member 1transporter
DB00731NateglinideSolute carrier family 15 member 2transporter
DB00731NateglinideSolute carrier family 22 member 6transporter
DB00731NateglinideMonocarboxylate transporter 1transporter
DB00731NateglinideProstaglandin G/H synthase 1enzyme
DB00731NateglinideUDP-glucuronosyltransferase 1-9enzyme
DB00731NateglinideCytochrome P450 2D6enzyme
DB00731NateglinideMultidrug resistance-associated protein 4transporter
DB00731NateglinideSerum albumincarrier
DB00731NateglinideAlpha-1-acid glycoprotein 1carrier
DB00839TolazamideSulfonylurea receptor 1, Kir6.2target
DB00839TolazamideCytochrome P450 2C9enzyme
DB00912RepaglinideATP-binding cassette sub-family C member 8target
DB00912RepaglinideCytochrome P450 2C8enzyme
DB00912RepaglinidePeroxisome proliferator-activated receptor gammatarget
DB00912RepaglinideCytochrome P450 3A4enzyme
DB00912RepaglinideSerum albumincarrier
DB00912RepaglinideSolute carrier organic anion transporter family member 1B1transporter
DB00912RepaglinideBile salt export pumptransporter
DB00914Phenformin5'-AMP-activated protein kinase catalytic subunit alpha-1target
DB00914PhenforminCytochrome P450 2D6enzyme
DB00914PhenforminSolute carrier family 22 member 2transporter
DB00914PhenforminSolute carrier family 22 member 1transporter
DB00914PhenforminATP-sensitive inward rectifier potassium channel 8target
DB01016GlyburideATP-binding cassette sub-family C member 9target
DB01016GlyburideBile salt export pumptarget
DB01016GlyburideATP-binding cassette sub-family A member 1target
DB01016GlyburideCystic fibrosis transmembrane conductance regulatortarget
DB01016GlyburideSulfonylurea receptor 1, Kir6.2target
DB01016GlyburideCytochrome P450 2C9enzyme
DB01016GlyburideCanalicular multispecific organic anion transporter 2transporter
DB01016GlyburideBile salt export pumptransporter
DB01016GlyburideP-glycoprotein 1transporter
DB01016GlyburideMultidrug resistance-associated protein 1transporter
DB01016GlyburideSolute carrier family 15 member 1transporter
DB01016GlyburideSolute carrier organic anion transporter family member 1A2transporter
DB01016GlyburideSolute carrier family 15 member 2transporter
DB01016GlyburideSolute carrier family 22 member 6transporter
DB01016GlyburideCanalicular multispecific organic anion transporter 1transporter
DB01016GlyburideATP-binding cassette sub-family G member 2transporter
DB01016GlyburideSolute carrier family 22 member 7transporter
DB01016GlyburideSolute carrier organic anion transporter family member 2B1transporter
DB01016GlyburideCytochrome P450 2C19enzyme
DB01016GlyburideCytochrome P450 3A4enzyme
DB01016GlyburideSerum albumincarrier
DB01016GlyburideMitochondrial ATP-sensitive potassium channeltarget
DB01016GlyburideCarnitine O-palmitoyltransferase 1, liver isoformtarget
DB01016GlyburideCytochrome P450 3A7enzyme
DB01016GlyburideCytochrome P450 3A5enzyme
DB01016GlyburideTransient receptor potential cation channel subfamily M member 4target
DB01067GlipizideCytochrome P450 2C9enzyme
DB01067GlipizidePeroxisome proliferator-activated receptor gammatarget
DB01067GlipizideATP-binding cassette sub-family C member 8target
DB01067GlipizideUDP-glucuronosyltransferase 1-1enzyme
DB01067GlipizideBile salt export pumptransporter
DB01067GlipizideSerum albumincarrier
DB01120GliclazideATP-binding cassette sub-family C member 8target
DB01120GliclazideSerum albumincarrier
DB01120GliclazideVascular endothelial growth factor Atarget
DB01120GliclazideCytochrome P450 2C9enzyme
DB01120GliclazideCytochrome P450 2C19enzyme
DB01132PioglitazonePeroxisome proliferator-activated receptor gammatarget
DB01132PioglitazoneCytochrome P450 2C8enzyme
DB01132PioglitazoneCytochrome P450 3A4enzyme
DB01132PioglitazoneSolute carrier organic anion transporter family member 1B3transporter
DB01132PioglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB01132PioglitazoneProstaglandin G/H synthase 1enzyme
DB01132PioglitazoneCytochrome P450 2C9enzyme
DB01132PioglitazonePeroxisome proliferator-activated receptor deltatarget
DB01132PioglitazonePeroxisome proliferator-activated receptor alphatarget
DB01132PioglitazoneAmine oxidase [flavin-containing] Btarget
DB01251GliquidoneATP-binding cassette sub-family C member 8target
DB01251GliquidoneATP-sensitive inward rectifier potassium channel 8target
DB01251GliquidoneCytochrome P450 2C9enzyme
DB01252MitiglinideATP-binding cassette sub-family C member 8target
DB01252MitiglinidePeroxisome proliferator-activated receptor gammatarget
DB01252MitiglinideUDP-glucuronosyltransferase 1-3enzyme
DB01252MitiglinideUDP-glucuronosyltransferase 2B7enzyme
DB01261SitagliptinDipeptidyl peptidase 4target
DB01261SitagliptinCytochrome P450 3A4enzyme
DB01261SitagliptinCytochrome P450 2C8enzyme
DB01261SitagliptinP-glycoprotein 1transporter
DB01261SitagliptinSolute carrier family 22 member 8transporter
DB01276ExenatideGlucagon-like peptide 1 receptortarget
DB01276ExenatideSerum albumincarrier
DB01276ExenatideDipeptidyl peptidase 4enzyme
DB01278PramlintideReceptor activity-modifying protein 1target
DB01278PramlintideReceptor activity-modifying protein 2target
DB01278PramlintideReceptor activity-modifying protein 3target
DB01278PramlintideCalcitonin receptortarget
DB01289GlisoxepideATP-sensitive inward rectifier potassium channel 8target
DB01289GlisoxepideCytochrome P450 2C9enzyme
DB01306Insulin AspartInsulin receptortarget
DB01306Insulin AspartInsulin-like growth factor 1 receptortarget
DB01306Insulin AspartCytochrome P450 1A2enzyme
DB01307Insulin DetemirInsulin receptortarget
DB01307Insulin DetemirSerum albumincarrier
DB01307Insulin DetemirInsulin-like growth factor 1 receptortarget
DB01307Insulin DetemirCytochrome P450 1A2enzyme
DB01309Insulin GlulisineInsulin receptortarget
DB01309Insulin GlulisineInsulin-like growth factor 1 receptortarget
DB01309Insulin GlulisineCytochrome P450 1A2enzyme
DB01382GlymidineATP-sensitive inward rectifier potassium channel 1target
DB01382GlymidineATP-binding cassette sub-family C member 8target
DB02383TolrestatAldose reductasetarget
DB02383TolrestatAlcohol dehydrogenase [NADP(+)]target
DB02383TolrestatAldo-keto reductase family 1 member B10target
DB04830BuforminSolute carrier family 22 member 1transporter
DB04876VildagliptinDipeptidyl peptidase 4target
DB04878VogliboseMaltase-glucoamylase, intestinaltarget
DB06203AlogliptinDipeptidyl peptidase 4target
DB06203AlogliptinCytochrome P450 3A4enzyme
DB06203AlogliptinCytochrome P450 2D6enzyme
DB06292DapagliflozinSodium/glucose cotransporter 2target
DB06292DapagliflozinCytochrome P450 1A1enzyme
DB06292DapagliflozinCytochrome P450 1A2enzyme
DB06292DapagliflozinCytochrome P450 2A6enzyme
DB06292DapagliflozinCytochrome P450 2C9enzyme
DB06292DapagliflozinCytochrome P450 2D6enzyme
DB06292DapagliflozinCytochrome P450 3A4enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 1-9enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 2B4enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 2B7enzyme
DB06292DapagliflozinP-glycoprotein 1transporter
DB06335SaxagliptinDipeptidyl peptidase 4target
DB06335SaxagliptinCytochrome P450 3A4enzyme
DB06335SaxagliptinCytochrome P450 3A5enzyme
DB06335SaxagliptinMultidrug resistance-associated protein 1transporter
DB06335SaxagliptinSolute carrier organic anion transporter family member 4C1transporter
DB06335SaxagliptinSolute carrier family 22 member 8transporter
DB06655LiraglutideGlucagon-like peptide 1 receptortarget
DB06655LiraglutideDipeptidyl peptidase 4enzyme
DB06655LiraglutideNeprilysinenzyme
DB06655LiraglutideSerum albumincarrier
DB08882LinagliptinDipeptidyl peptidase 4target
DB08882LinagliptinCytochrome P450 3A4enzyme
DB08882LinagliptinP-glycoprotein 1transporter
DB08882LinagliptinSolute carrier family 22 member 1transporter
DB08882LinagliptinSolute carrier family 22 member 2transporter
DB08882LinagliptinSolute carrier family 22 member 3transporter
DB08907CanagliflozinUDP-glucuronosyltransferase 1-9enzyme
DB08907CanagliflozinUDP-glucuronosyltransferase 2B4enzyme
DB08907CanagliflozinCytochrome P450 3A4enzyme
DB08907CanagliflozinSodium/glucose cotransporter 2target
DB08907CanagliflozinP-glycoprotein 1transporter
DB08907CanagliflozinCanalicular multispecific organic anion transporter 1transporter
DB08907CanagliflozinAlpha-1-acid glycoprotein 1carrier
DB08907CanagliflozinATP-binding cassette sub-family G member 2transporter
DB08962GlibornurideCytochrome P450 2C9enzyme
DB09038EmpagliflozinSodium/glucose cotransporter 2target
DB09043AlbiglutideGlucagon-like peptide 1 receptortarget
DB09045DulaglutideGlucagon-like peptide 1 receptortarget
DB09265LixisenatideGlucagon-like peptide 1 receptortarget
DB09456Insulin BeefCytochrome P450 1A2enzyme
DB09564Insulin DegludecInsulin receptortarget
DB09564Insulin DegludecInsulin-like growth factor 1 receptortarget
DB09564Insulin DegludecSerum albumincarrier
DB09564Insulin DegludecCytochrome P450 1A2enzyme
DB13406CarbutamideCytochrome P450 2C9enzyme
DB13675MetahexamideCytochrome P450 2C9enzyme
DB00641Simvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB00641SimvastatinCytochrome P450 3A4enzyme
DB00641SimvastatinCytochrome P450 2C8enzyme
DB00641SimvastatinCytochrome P450 2C9enzyme
DB00641SimvastatinCytochrome P450 3A5enzyme
DB00641SimvastatinP-glycoprotein 1transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1A2transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1B1transporter
DB00641SimvastatinCytochrome P450 2B6enzyme
DB00641SimvastatinCytochrome P450 2D6enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 1-1enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 1-3enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 2B7enzyme
DB00641SimvastatinCanalicular multispecific organic anion transporter 1transporter
DB00641SimvastatinIntegrin alpha-Ltarget
DB00641SimvastatinBile salt export pumptransporter
DB00641SimvastatinCytochrome P450 2C19enzyme
DB00641SimvastatinSolute carrier organic anion transporter family member 2B1transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1B3transporter
DB00641SimvastatinHistone deacetylase 2target
DB01124TolbutamideATP-sensitive inward rectifier potassium channel 1target
DB01124TolbutamideCytochrome P450 2C19enzyme
DB01124TolbutamideCytochrome P450 2C9enzyme
DB01124TolbutamideCytochrome P450 2C8enzyme
DB01124TolbutamideATP-binding cassette sub-family C member 8target
DB01124TolbutamideSolute carrier family 15 member 1transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 1A2transporter
DB01124TolbutamideSolute carrier family 15 member 2transporter
DB01124TolbutamideSolute carrier family 22 member 6transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 2B1transporter
DB01124TolbutamideCytochrome P450 2C18enzyme
DB01124TolbutamideSerum albumincarrier
DB01098Rosuvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01098RosuvastatinCytochrome P450 2C9enzyme
DB01098RosuvastatinMultidrug resistance-associated protein 4transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01098RosuvastatinCystine/glutamate transportertransporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01098RosuvastatinBile salt export pumptransporter
DB01098RosuvastatinATP-binding cassette sub-family G member 2transporter
DB01098RosuvastatinSerum albumincarrier
DB01098RosuvastatinCanalicular multispecific organic anion transporter 1transporter
DB01098RosuvastatinSolute carrier family 22 member 8transporter
DB01098RosuvastatinSodium/bile acid cotransportertransporter
DB01098RosuvastatinIntegrin alpha-Ltarget
DB11827ErtugliflozinUDP-glucuronosyltransferase 1-9enzyme
DB11827ErtugliflozinUDP-glucuronosyltransferase 2B7enzyme
DB11827ErtugliflozinSodium/glucose cotransporter 2target
DB11827ErtugliflozinP-glycoprotein 1transporter
DB11827ErtugliflozinATP-binding cassette sub-family G member 2transporter
DB11827ErtugliflozinSerum albumincarrier
DB11827ErtugliflozinUDP-glucuronosyltransferase 1-1enzyme
DB11827ErtugliflozinUDP-glucuronosyltransferase 1-4enzyme
DB13928SemaglutideSerum albumincarrier
DB13928SemaglutideDipeptidyl peptidase 4enzyme
DB13928SemaglutideNeprilysinenzyme
DB13928SemaglutideGlucagon-like peptide 1 receptortarget
DB13928SemaglutideSolute carrier organic anion transporter family member 1B1transporter
DB13928SemaglutideSolute carrier organic anion transporter family member 1B3transporter
DB13928SemaglutideLipoprotein lipaseenzyme
DB13928SemaglutideAlpha-amylase 1enzyme