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Identification
NameVinorelbine
Accession NumberDB00361  (APRD00101)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionVinorelbine (Navelbine®) is an anti-mitotic chemotherapy drug that is given as a treatment for some types of cancer, including breast cancer and non-small cell lung cancer. [Wikipedia]
Structure
Thumb
Synonyms
5'-Noranhydrovinblastine
Nor-5'-anhydrovinblastine
Vinorelbin
Vinorelbina
Vinorelbine
Vinorelbinum
External Identifiers
  • KW 2307 base
  • KW-2307
  • UNII-253GQW851Q
  • UNII-Q6C979R91Y
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Aj-vinorelbineSolution10 mgIntravenousAgila Jamp Canada IncNot applicableNot applicableCanada
NavelbineInjection10 mg/mLIntravenousPierre Fabre Pharmaceuticals, Inc.2005-11-15Not applicableUs
NavelbineSolution10 mgIntravenousPierre Fabre Pharma Canada Inc1994-12-312012-10-01Canada
Vinorelbine InjectionSolution10 mgIntravenousFresenius Kabi Canada Ltd2009-03-31Not applicableCanada
Vinorelbine Injection, USPSolution10 mgIntravenousMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Vinorelbine Injection, USPSolution10 mgIntravenousGeneric Medical Partners IncNot applicableNot applicableCanada
Vinorelbine Tartrate for InjectionSolution10 mgIntravenousHospira Healthcare Corporation2004-12-22Not applicableCanada
Vinorelbine Tartrate for InjectionSolution10 mgIntravenousTeva Canada Limited2007-05-09Not applicableCanada
Vinorelbine Tartrate Injection USPSolution10 mgIntravenousSandoz Canada IncorporatedNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
VinorelbineInjection, solution10 mg/mLIntravenousActavis Pharma, Inc.2009-09-14Not applicableUs
VinorelbineInjection, solution10 mg/mLIntravenousMylan Institutional LLC2012-09-01Not applicableUs
VinorelbineInjection, solution, concentrate10 mg/mLIntravenousTeva Parenteral Medicines, Inc.2003-03-01Not applicableUs
VinorelbineInjection, solution10 mg/mLIntravenousPfizer Laboratories Div Pfizer Inc.2012-09-01Not applicableUs
VinorelbineInjection, solution10 mg/mLIntravenousMylan Institutional LLC2012-09-01Not applicableUs
VinorelbineInjection, solution, concentrate50 mg/5mLIntravenousTeva Parenteral Medicines, Inc.2003-03-01Not applicableUs
VinorelbineInjection, solution10 mg/mLIntravenousMylan Institutional LLC2012-09-01Not applicableUs
VinorelbineInjection, solution10 mg/mLIntravenousPfizer Laboratories Div Pfizer Inc.2012-09-01Not applicableUs
VinorelbineInjection, solution10 mg/mLIntravenousHospira, Inc.2005-06-02Not applicableUs
VinorelbineInjection, solution10 mg/mLIntravenousSagent Pharmaceuticals2014-09-15Not applicableUs
VinorelbineInjection, solution10 mg/mLIntravenousMylan Institutional LLC2012-09-01Not applicableUs
VinorelbineInjection, solution10 mg/mLIntravenousPfizer Laboratories Div Pfizer Inc.2012-09-01Not applicableUs
Vinorelbine TartrateInjection, solution10 mg/mLIntravenousWyeth Pharmaceuticals Company2008-02-13Not applicableUs
Vinorelbine TartrateInjection, solution10 mg/mLIntravenousSandoz Inc.2008-02-13Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
BendarelbinBendalis
EberelbinEbewe
EunexonAC Farma
EurovinorelbinLapharm
FilcrinFilaxis
NavelbinPierre Fabre
NavildezCryopharma
NavinCancernova
Navirelmedac
NeocitecSandoz
RenovelMustafa Nevzat
RiborelbinRibosepharm
VilneDosa
VinelbineGP-Pharm
VinorayneHospira
VinorelEriochem
VinorgenBago
VinotelFresenius
ZinavinNovamed
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Vinorelbine Ditartrate
ThumbNot applicableDBSALT001060
Vinorelbine Tartrate
Thumb
  • InChI Key: CILBMBUYJCWATM-KRQCOKQWSA-N
  • Monoisotopic Mass: 1078.427040572
  • Average Mass: 1079.1059
DBSALT000447
Categories
UNIIQ6C979R91Y
CAS number71486-22-1
WeightAverage: 778.9323
Monoisotopic: 778.394164724
Chemical FormulaC45H54N4O8
InChI KeyGBABOYUKABKIAF-GHYRFKGUSA-N
InChI
InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45+/m0/s1
IUPAC Name
methyl (1R,9R,10R,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(12S,14R)-16-ethyl-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0³,¹¹.0⁴,⁹]octadeca-3(11),4,6,8,15-pentaen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate
SMILES
[H][C@@]12N(C)C3=CC(OC)=C(C=C3[C@@]11CCN3CC=C[C@@](CC)([C@@H](OC(C)=O)[C@@]2(O)C(=O)OC)[C@@]13[H])[C@]1(C[C@@]2([H])CN(CC(CC)=C2)CC2=C1NC1=CC=CC=C21)C(=O)OC
Pharmacology
IndicationFor the treatment of non-small-cell lung carcinoma.
Structured Indications
PharmacodynamicsVinorelbine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vinorelbine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Mechanism of actionThe antitumor activity of vinorelbine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Like other vinca alkaloids, vinorelbine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.
TargetKindPharmacological actionActionsOrganismUniProt ID
Tubulin beta chainProteinyes
inhibitor
HumanP07437 details
Related Articles
AbsorptionNot Available
Volume of distribution
  • 25.4 to 40.1 L/kg
Protein binding~27%
MetabolismNot Available
Route of eliminationVinorelbine undergoes substantial hepatic elimination in humans, with large amounts recovered in feces after intravenous administration to humans.
Half life27.7-43.6 hours
Clearance
  • 0.97 – 1.26 L/hr/kg
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Vinorelbine Action PathwayDrug actionSMP00439
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbirateroneThe serum concentration of Vinorelbine can be increased when it is combined with Abiraterone.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Vinorelbine.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Vinorelbine.Approved
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Vinorelbine.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Vinorelbine.Approved, Vet Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Vinorelbine.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Vinorelbine.Experimental
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Vinorelbine.Approved, Investigational
ALT-110The risk or severity of adverse effects can be increased when Vinorelbine is combined with ALT-110.Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Vinorelbine.Approved, Investigational
AmiodaroneThe metabolism of Vinorelbine can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Vinorelbine.Approved
AnvirzelAnvirzel may decrease the cardiotoxic activities of Vinorelbine.Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Vinorelbine.Approved
AprepitantThe serum concentration of Vinorelbine can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Vinorelbine.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Vinorelbine.Approved, Investigational
ArtemetherThe metabolism of Vinorelbine can be decreased when combined with Artemether.Approved
AtazanavirThe metabolism of Vinorelbine can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Vinorelbine.Approved
AtomoxetineThe metabolism of Vinorelbine can be decreased when combined with Atomoxetine.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Vinorelbine.Approved, Investigational
BcgThe therapeutic efficacy of Bcg can be decreased when used in combination with Vinorelbine.Investigational
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Vinorelbine.Approved, Vet Approved
BetaxololThe metabolism of Vinorelbine can be decreased when combined with Betaxolol.Approved
BevacizumabBevacizumab may increase the cardiotoxic activities of Vinorelbine.Approved, Investigational
BexaroteneThe serum concentration of Vinorelbine can be decreased when it is combined with Bexarotene.Approved, Investigational
BoceprevirThe metabolism of Vinorelbine can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Vinorelbine can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Vinorelbine can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Vinorelbine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Vinorelbine.Approved
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Vinorelbine.Approved, Investigational
BupropionThe metabolism of Vinorelbine can be decreased when combined with Bupropion.Approved
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Vinorelbine.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Vinorelbine.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Vinorelbine.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Vinorelbine.Approved
CarbamazepineThe metabolism of Vinorelbine can be increased when combined with Carbamazepine.Approved, Investigational
CarbomycinThe serum concentration of Vinorelbine can be increased when it is combined with Carbomycin.Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Vinorelbine.Approved
CDX-110The risk or severity of adverse effects can be increased when Vinorelbine is combined with CDX-110.Investigational
CelecoxibThe metabolism of Vinorelbine can be decreased when combined with Celecoxib.Approved, Investigational
CeritinibThe serum concentration of Vinorelbine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Vinorelbine.Withdrawn
ChloroquineThe metabolism of Vinorelbine can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Vinorelbine.Approved, Vet Approved
CholecalciferolThe metabolism of Vinorelbine can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Vinorelbine.Approved
CinacalcetThe metabolism of Vinorelbine can be decreased when combined with Cinacalcet.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Vinorelbine.Approved, Investigational
CisplatinThe risk or severity of adverse effects can be increased when Cisplatin is combined with Vinorelbine.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Vinorelbine.Approved
ClarithromycinThe metabolism of Vinorelbine can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Vinorelbine can be decreased when combined with Clemastine.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Vinorelbine.Approved, Illicit
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Vinorelbine.Approved, Investigational
ClomipramineThe metabolism of Vinorelbine can be decreased when combined with Clomipramine.Approved, Vet Approved
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Vinorelbine.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Vinorelbine.Approved, Nutraceutical
ClotrimazoleThe metabolism of Vinorelbine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Vinorelbine is combined with Clozapine.Approved
CobicistatThe serum concentration of Vinorelbine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Vinorelbine.Approved
CocaineThe metabolism of Vinorelbine can be decreased when combined with Cocaine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Vinorelbine.Approved
ConivaptanThe serum concentration of Vinorelbine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Vinorelbine.Approved
CrizotinibThe metabolism of Vinorelbine can be decreased when combined with Crizotinib.Approved
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Vinorelbine.Approved, Investigational
CyclosporineThe metabolism of Vinorelbine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Vinorelbine.Approved
DabrafenibThe serum concentration of Vinorelbine can be decreased when it is combined with Dabrafenib.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Vinorelbine.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Vinorelbine.Approved
DarifenacinThe metabolism of Vinorelbine can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Vinorelbine can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Vinorelbine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Vinorelbine.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Vinorelbine.Approved
DeferasiroxThe serum concentration of Vinorelbine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Vinorelbine can be decreased when combined with Delavirdine.Approved
DenosumabThe risk or severity of adverse effects can be increased when Denosumab is combined with Vinorelbine.Approved
DesipramineThe metabolism of Vinorelbine can be decreased when combined with Desipramine.Approved
DeslanosideDeslanoside may decrease the cardiotoxic activities of Vinorelbine.Approved
DexamethasoneThe serum concentration of Vinorelbine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Vinorelbine.Approved, Illicit, Vet Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Vinorelbine.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Vinorelbine.Approved
DigoxinDigoxin may decrease the cardiotoxic activities of Vinorelbine.Approved
DihydroergotamineThe metabolism of Vinorelbine can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Vinorelbine.Illicit
DiltiazemThe metabolism of Vinorelbine can be decreased when combined with Diltiazem.Approved
DiphenhydramineThe metabolism of Vinorelbine can be decreased when combined with Diphenhydramine.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Vinorelbine.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Vinorelbine.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Vinorelbine.Approved, Investigational, Vet Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Vinorelbine.Approved, Investigational
DoxycyclineThe metabolism of Vinorelbine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Vinorelbine can be decreased when combined with Dronedarone.Approved
DuloxetineThe metabolism of Vinorelbine can be decreased when combined with Duloxetine.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Vinorelbine.Approved
EfavirenzThe serum concentration of Vinorelbine can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Vinorelbine.Approved, Investigational
EliglustatThe metabolism of Vinorelbine can be decreased when combined with Eliglustat.Approved
EnzalutamideThe serum concentration of Vinorelbine can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Vinorelbine.Approved, Investigational
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Vinorelbine.Approved, Investigational
ErythromycinThe serum concentration of Vinorelbine can be increased when it is combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of Vinorelbine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Vinorelbine.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Vinorelbine.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Vinorelbine.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Vinorelbine.Approved
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Vinorelbine.Approved
EtravirineThe serum concentration of Vinorelbine can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Vinorelbine.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Vinorelbine.Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Vinorelbine.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Vinorelbine.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Vinorelbine.Approved
FingolimodVinorelbine may increase the immunosuppressive activities of Fingolimod.Approved, Investigational
FluconazoleThe metabolism of Vinorelbine can be decreased when combined with Fluconazole.Approved
FluoxetineThe metabolism of Vinorelbine can be decreased when combined with Fluoxetine.Approved, Vet Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Vinorelbine.Approved
FluvoxamineThe metabolism of Vinorelbine can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Vinorelbine can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Vinorelbine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Vinorelbine can be increased when combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Vinorelbine can be increased when it is combined with Fusidic Acid.Approved
G17DTThe risk or severity of adverse effects can be increased when Vinorelbine is combined with G17DT.Investigational
GefitinibGefitinib may increase the neutropenic activities of Vinorelbine.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Vinorelbine.Approved
GI-5005The risk or severity of adverse effects can be increased when Vinorelbine is combined with GI-5005.Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Vinorelbine.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Vinorelbine.Withdrawn
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Vinorelbine.Approved
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Vinorelbine.Approved, Vet Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Vinorelbine.Approved
IdelalisibThe serum concentration of Vinorelbine can be increased when it is combined with Idelalisib.Approved
ImatinibThe metabolism of Vinorelbine can be decreased when combined with Imatinib.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Vinorelbine.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Vinorelbine.Approved
IndinavirThe metabolism of Vinorelbine can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Vinorelbine.Approved, Investigational
INGN 201The risk or severity of adverse effects can be increased when Vinorelbine is combined with INGN 201.Investigational
INGN 225The risk or severity of adverse effects can be increased when Vinorelbine is combined with INGN 225.Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Vinorelbine.Approved, Investigational
IsavuconazoniumThe metabolism of Vinorelbine can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoniazidThe metabolism of Vinorelbine can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Vinorelbine can be decreased when combined with Isradipine.Approved
ItraconazoleThe risk or severity of adverse effects can be increased when Itraconazole is combined with Vinorelbine.Approved, Investigational
IvacaftorThe serum concentration of Vinorelbine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Vinorelbine.Approved, Vet Approved
JosamycinThe serum concentration of Vinorelbine can be increased when it is combined with Josamycin.Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Vinorelbine.Approved
KetoconazoleThe metabolism of Vinorelbine can be decreased when combined with Ketoconazole.Approved, Investigational
KitasamycinThe serum concentration of Vinorelbine can be increased when it is combined with Kitasamycin.Experimental
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Vinorelbine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Vinorelbine.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Vinorelbine.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Vinorelbine.Approved
LeflunomideThe risk or severity of adverse effects can be increased when Vinorelbine is combined with Leflunomide.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Vinorelbine.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Vinorelbine.Approved
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Vinorelbine.Approved, Investigational
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Vinorelbine.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Vinorelbine.Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Vinorelbine.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Vinorelbine.Approved
LopinavirThe metabolism of Vinorelbine can be decreased when combined with Lopinavir.Approved
LorcaserinThe metabolism of Vinorelbine can be decreased when combined with Lorcaserin.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Vinorelbine.Approved
LovastatinThe metabolism of Vinorelbine can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Vinorelbine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Vinorelbine can be increased when combined with Lumacaftor.Approved
LumefantrineThe metabolism of Vinorelbine can be decreased when combined with Lumefantrine.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Vinorelbine.Approved, Investigational
MetamizoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Vinorelbine.Withdrawn
MethadoneThe metabolism of Vinorelbine can be decreased when combined with Methadone.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Vinorelbine.Approved
MethotrimeprazineThe metabolism of Vinorelbine can be decreased when combined with Methotrimeprazine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Vinorelbine.Approved, Vet Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Vinorelbine.Approved, Investigational
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Vinorelbine.Approved, Illicit
MifepristoneThe serum concentration of Vinorelbine can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Vinorelbine.Approved
MitomycinThe risk or severity of adverse effects can be increased when Vinorelbine is combined with Mitomycin.Approved
MitotaneThe serum concentration of Vinorelbine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Vinorelbine.Approved, Investigational
ModafinilThe serum concentration of Vinorelbine can be decreased when it is combined with Modafinil.Approved, Investigational
MorphineThe serum concentration of Morphine can be increased when it is combined with Vinorelbine.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Vinorelbine.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Vinorelbine.Approved
NafcillinThe serum concentration of Vinorelbine can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Vinorelbine.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Vinorelbine.Approved, Vet Approved
NatalizumabThe risk or severity of adverse effects can be increased when Vinorelbine is combined with Natalizumab.Approved, Investigational
NefazodoneThe metabolism of Vinorelbine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Vinorelbine can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Vinorelbine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Vinorelbine can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Vinorelbine.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Vinorelbine.Approved
NilotinibThe metabolism of Vinorelbine can be decreased when combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Vinorelbine.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Vinorelbine.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Vinorelbine.Approved, Investigational
OlaparibThe metabolism of Vinorelbine can be decreased when combined with Olaparib.Approved
OleandomycinThe serum concentration of Vinorelbine can be increased when it is combined with Oleandomycin.Vet Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Vinorelbine.Approved
OsimertinibThe serum concentration of Vinorelbine can be increased when it is combined with Osimertinib.Approved
OuabainOuabain may decrease the cardiotoxic activities of Vinorelbine.Approved
PaclitaxelPaclitaxel may increase the neurotoxic activities of Vinorelbine.Approved, Vet Approved
PalbociclibThe serum concentration of Vinorelbine can be increased when it is combined with Palbociclib.Approved
PanobinostatThe serum concentration of Vinorelbine can be increased when it is combined with Panobinostat.Approved, Investigational
ParoxetineThe metabolism of Vinorelbine can be decreased when combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Vinorelbine.Approved
Peginterferon alfa-2bThe serum concentration of Vinorelbine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentobarbitalThe metabolism of Vinorelbine can be increased when combined with Pentobarbital.Approved, Vet Approved
PhenobarbitalThe metabolism of Vinorelbine can be increased when combined with Phenobarbital.Approved
PhenytoinThe metabolism of Vinorelbine can be increased when combined with Phenytoin.Approved, Vet Approved
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Vinorelbine.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Vinorelbine.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Vinorelbine.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Vinorelbine.Approved
PosaconazoleThe risk or severity of adverse effects can be increased when Posaconazole is combined with Vinorelbine.Approved, Investigational, Vet Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Vinorelbine.Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Vinorelbine.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Vinorelbine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Vinorelbine.Approved, Vet Approved
PrimidoneThe metabolism of Vinorelbine can be increased when combined with Primidone.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Vinorelbine.Approved, Vet Approved
PromazineThe metabolism of Vinorelbine can be decreased when combined with Promazine.Approved, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Vinorelbine.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Vinorelbine.Approved
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Vinorelbine.Approved
QuinidineThe metabolism of Vinorelbine can be decreased when combined with Quinidine.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Vinorelbine.Approved
Rabies vaccineThe risk or severity of adverse effects can be increased when Vinorelbine is combined with Rabies vaccine.Approved
Rabies vaccineThe therapeutic efficacy of Rabies vaccine can be decreased when used in combination with Vinorelbine.Approved
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Vinorelbine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Vinorelbine.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Vinorelbine.Approved
RifabutinThe metabolism of Vinorelbine can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Vinorelbine can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Vinorelbine can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Vinorelbine.Approved, Investigational
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Vinorelbine.Approved, Investigational
RitonavirThe metabolism of Vinorelbine can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Vinorelbine.Approved
RoflumilastRoflumilast may increase the immunosuppressive activities of Vinorelbine.Approved
RolapitantThe metabolism of Vinorelbine can be decreased when combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Vinorelbine.Approved, Investigational
RopiniroleThe metabolism of Vinorelbine can be decreased when combined with Ropinirole.Approved, Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Vinorelbine.Approved, Vet Approved
SaquinavirThe metabolism of Vinorelbine can be decreased when combined with Saquinavir.Approved, Investigational
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Vinorelbine.Approved
SertralineThe metabolism of Vinorelbine can be decreased when combined with Sertraline.Approved
SildenafilThe metabolism of Vinorelbine can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Vinorelbine.Approved
SiltuximabThe serum concentration of Vinorelbine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Vinorelbine can be increased when it is combined with Simeprevir.Approved
Sipuleucel-TThe therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Vinorelbine.Approved
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Vinorelbine.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Vinorelbine.Approved
SolithromycinThe serum concentration of Vinorelbine can be increased when it is combined with Solithromycin.Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Vinorelbine.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Vinorelbine.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Vinorelbine.Experimental
SpiramycinThe serum concentration of Vinorelbine can be increased when it is combined with Spiramycin.Approved
SRP 299The risk or severity of adverse effects can be increased when Vinorelbine is combined with SRP 299.Investigational
St. John's WortThe serum concentration of Vinorelbine can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Vinorelbine can be increased when it is combined with Stiripentol.Approved
SulfisoxazoleThe metabolism of Vinorelbine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
TacrolimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Vinorelbine.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Vinorelbine.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Vinorelbine.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Vinorelbine.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Vinorelbine.Approved
TelaprevirThe metabolism of Vinorelbine can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Vinorelbine can be decreased when combined with Telithromycin.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Vinorelbine.Approved
TerbinafineThe metabolism of Vinorelbine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TG4010The risk or severity of adverse effects can be increased when Vinorelbine is combined with TG4010.Investigational
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Vinorelbine.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Vinorelbine.Approved
TiclopidineThe metabolism of Vinorelbine can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Vinorelbine.Approved
TipranavirThe metabolism of Vinorelbine can be decreased when combined with Tipranavir.Approved, Investigational
TocilizumabThe serum concentration of Vinorelbine can be decreased when it is combined with Tocilizumab.Approved
TofacitinibVinorelbine may increase the immunosuppressive activities of Tofacitinib.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Vinorelbine.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Vinorelbine.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Vinorelbine.Approved, Investigational
TranylcypromineThe metabolism of Vinorelbine can be decreased when combined with Tranylcypromine.Approved
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Vinorelbine.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Vinorelbine.Approved
TroleandomycinThe serum concentration of Vinorelbine can be increased when it is combined with Troleandomycin.Approved
TylosinThe serum concentration of Vinorelbine can be increased when it is combined with Tylosin.Vet Approved
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Vinorelbine.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Vinorelbine.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Vinorelbine.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Vinorelbine.Approved
VenlafaxineThe metabolism of Vinorelbine can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Vinorelbine can be decreased when combined with Verapamil.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Vinorelbine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Vinorelbine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Vinorelbine.Approved
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Vinorelbine.Approved, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Vinorelbine.Approved
ZiprasidoneThe metabolism of Vinorelbine can be decreased when combined with Ziprasidone.Approved
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General References
  1. Marty M, Fumoleau P, Adenis A, Rousseau Y, Merrouche Y, Robinet G, Senac I, Puozzo C: Oral vinorelbine pharmacokinetics and absolute bioavailability study in patients with solid tumors. Ann Oncol. 2001 Nov;12(11):1643-9. [PubMed:11822766 ]
External Links
ATC CodesL01CA04
AHFS Codes
  • 10:00.00
PDB Entries
FDA labelDownload (102 KB)
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.974
Blood Brain Barrier-0.8815
Caco-2 permeable+0.5602
P-glycoprotein substrateSubstrate0.9283
P-glycoprotein inhibitor IInhibitor0.7488
P-glycoprotein inhibitor IIInhibitor0.7388
Renal organic cation transporterNon-inhibitor0.6979
CYP450 2C9 substrateNon-substrate0.8513
CYP450 2D6 substrateSubstrate0.6471
CYP450 3A4 substrateSubstrate0.7247
CYP450 1A2 substrateNon-inhibitor0.8415
CYP450 2C9 inhibitorNon-inhibitor0.7863
CYP450 2D6 inhibitorNon-inhibitor0.8369
CYP450 2C19 inhibitorNon-inhibitor0.8381
CYP450 3A4 inhibitorNon-inhibitor0.8095
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6672
Ames testNon AMES toxic0.8064
CarcinogenicityNon-carcinogens0.9299
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.8350 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9014
hERG inhibition (predictor II)Non-inhibitor0.5171
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Pierre fabre medicament
  • Actavis totowa llc
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia and critical care
  • Bedford laboratories div ben venue laboratories inc
  • Ebewe pharma ges mbh nfg kg
  • Hospira inc
  • Teva parenteral medicines inc
Packagers
Dosage forms
FormRouteStrength
InjectionIntravenous10 mg/mL
Injection, solution, concentrateIntravenous10 mg/mL
Injection, solution, concentrateIntravenous50 mg/5mL
Injection, solutionIntravenous10 mg/mL
SolutionIntravenous10 mg
Prices
Unit descriptionCostUnit
Navelbine 50 mg/5 ml vial42.0USD ml
Vinorelbine 50 mg/5 ml vial27.6USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0122 mg/mLALOGPS
logP4.39ALOGPS
logP4.65ChemAxon
logS-4.8ALOGPS
pKa (Strongest Acidic)10.87ChemAxon
pKa (Strongest Basic)8.72ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area133.87 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity216.99 m3·mol-1ChemAxon
Polarizability84.7 Å3ChemAxon
Number of Rings9ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as vinca alkaloids. These are alkaloids with a dimeric chemical structure composed of an indole nucleus (catharanthine), and a dihydroindole nucleus (vindoline), joined together.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassVinca alkaloids
Sub ClassNot Available
Direct ParentVinca alkaloids
Alternative Parents
Substituents
  • Vinca alkaloid skeleton
  • Catharanthine skeleton
  • Carbazole
  • Indole or derivatives
  • Indole
  • Dialkylarylamine
  • Anisole
  • Aralkylamine
  • Tetrahydropyridine
  • Alkyl aryl ether
  • Benzenoid
  • N-alkylpyrrolidine
  • Dicarboxylic acid or derivatives
  • Heteroaromatic compound
  • Acetate salt
  • Methyl ester
  • Tertiary alcohol
  • Pyrrolidine
  • Pyrrole
  • Cyclic alcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Carboxylic acid ester
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Ubiquitin protein ligase binding
Specific Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Name:
TUBB
Uniprot ID:
P07437
Molecular Weight:
49670.515 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Kruczynski A, Barret JM, Etievant C, Colpaert F, Fahy J, Hill BT: Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid. Biochem Pharmacol. 1998 Mar 1;55(5):635-48. [PubMed:9515574 ]
  4. Chang AY, Garrow GC: Pilot study of vinorelbine (Navelbine) and paclitaxel (Taxol) in patients with refractory breast cancer and lung cancer. Semin Oncol. 1995 Apr;22(2 Suppl 5):66-70; discussion 70-1. [PubMed:7740336 ]
  5. Seve P, Dumontet C: [Class III beta tubulin expression in nonsmall cell lung cancer]. Rev Mal Respir. 2010 Apr;27(4):383-6. doi: 10.1016/j.rmr.2010.03.006. Epub 2010 Mar 25. [PubMed:20403547 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23